AU2006348662B8 - Inhibitors of Bruton's tyrosine kinase - Google Patents

Inhibitors of Bruton's tyrosine kinase Download PDF

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Publication number
AU2006348662B8
AU2006348662B8 AU2006348662A AU2006348662A AU2006348662B8 AU 2006348662 B8 AU2006348662 B8 AU 2006348662B8 AU 2006348662 A AU2006348662 A AU 2006348662A AU 2006348662 A AU2006348662 A AU 2006348662A AU 2006348662 B8 AU2006348662 B8 AU 2006348662B8
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AU
Australia
Prior art keywords
compound
formula
pyrazolo
phenoxyphenyl
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
AU2006348662A
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English (en)
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AU2006348662A1 (en
AU2006348662B2 (en
Inventor
Lee Honigberg
Zhengying Pan
Erik Verner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacyclics LLC
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Pharmacyclics LLC
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Application filed by Pharmacyclics LLC filed Critical Pharmacyclics LLC
Publication of AU2006348662A1 publication Critical patent/AU2006348662A1/en
Priority to AU2010201052A priority Critical patent/AU2010201052B2/en
Publication of AU2006348662B2 publication Critical patent/AU2006348662B2/en
Priority to AU2012205166A priority patent/AU2012205166B8/en
Application granted granted Critical
Publication of AU2006348662B8 publication Critical patent/AU2006348662B8/en
Assigned to PHARMACYCLICS LLC reassignment PHARMACYCLICS LLC Request to Amend Deed and Register Assignors: PHARMACYCLICS, INC.
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Oncology (AREA)
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  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
AU2006348662A 2006-09-22 2006-12-28 Inhibitors of Bruton's tyrosine kinase Active 2030-04-20 AU2006348662B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2010201052A AU2010201052B2 (en) 2006-09-22 2010-03-18 Inhibitors of Bruton's tyrosine kinase
AU2012205166A AU2012205166B8 (en) 2006-09-22 2012-07-16 Inhibitors of Bruton's tyrosine kinase

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82672006P 2006-09-22 2006-09-22
US60/826,720 2006-09-22
US82859006P 2006-10-06 2006-10-06
US60/828,590 2006-10-06
PCT/US2006/049626 WO2008039218A2 (en) 2006-09-22 2006-12-28 Inhibitors of bruton's tyrosine kinase

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2010201052A Division AU2010201052B2 (en) 2006-09-22 2010-03-18 Inhibitors of Bruton's tyrosine kinase
AU2012205166A Division AU2012205166B8 (en) 2006-09-22 2012-07-16 Inhibitors of Bruton's tyrosine kinase

Publications (3)

Publication Number Publication Date
AU2006348662A1 AU2006348662A1 (en) 2008-04-03
AU2006348662B2 AU2006348662B2 (en) 2012-04-19
AU2006348662B8 true AU2006348662B8 (en) 2014-05-29

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Application Number Title Priority Date Filing Date
AU2006348662A Active 2030-04-20 AU2006348662B8 (en) 2006-09-22 2006-12-28 Inhibitors of Bruton's tyrosine kinase
AU2010201052A Active AU2010201052B2 (en) 2006-09-22 2010-03-18 Inhibitors of Bruton's tyrosine kinase

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010201052A Active AU2010201052B2 (en) 2006-09-22 2010-03-18 Inhibitors of Bruton's tyrosine kinase

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