CY1118176T1 - Παραγωγα αζετιδινης και κυκλοβουτανιου ως αναστολεις των jak - Google Patents

Παραγωγα αζετιδινης και κυκλοβουτανιου ως αναστολεις των jak

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Publication number
CY1118176T1
CY1118176T1 CY20161101100T CY161101100T CY1118176T1 CY 1118176 T1 CY1118176 T1 CY 1118176T1 CY 20161101100 T CY20161101100 T CY 20161101100T CY 161101100 T CY161101100 T CY 161101100T CY 1118176 T1 CY1118176 T1 CY 1118176T1
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CY
Cyprus
Prior art keywords
humans
animals
vitro
azetidine
matched
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Application number
CY20161101100T
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English (en)
Inventor
James D Rodgers
Stacey Shepard
Yun-Long Li
Jiacheng Zhou
Pingli Liu
David Meloni
Michael Xia
Original Assignee
Incyte Holdings Corporation
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40591836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118176(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of CY1118176T1 publication Critical patent/CY1118176T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60Q—ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q3/00—Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors
    • B60Q3/70—Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors characterised by the purpose
    • B60Q3/76—Arrangement of lighting devices for vehicle interiors; Lighting devices specially adapted for vehicle interiors characterised by the purpose for spotlighting, e.g. reading lamps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60Q—ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
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    • B60Q3/80—Circuits; Control arrangements
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S362/00—Illumination
    • Y10S362/80—Light emitting diode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S362/00—Illumination
    • Y10S362/802—Position or condition responsive switch

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Mechanical Engineering (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η μέθοδος συμπεριλαμβάνει τα στάδια επιτέλεσης in vitro προσδιορισμών που αφορούν το ήπαρ, το έντερο και/ή εκφρασμένα ένζυμα με επιλεγμένες εθνοβοτανικές ενώσεις, σε αμφότερους τους ανθρώπους και ποικίλα ζωικά είδη, προς παραγωγή ενός συνόλου χημικών οντοτήτων, για παράδειγμα μεταβολίτες, προς χρήση στους ανθρώπους και στα ζώα. Κατόπιν επιτελούνται συγκρίσεις μεταξύ των χημικών οντοτήτων από τις in vitro μελέτες σε ανθρώπους και από τις in vitro μελέτες σε ζώα προκειμένου να προσδιοριστεί η πλέον ταιριαστή ένωση. Το ζώο με την πλέον ταιριαστή ένωση κατόπιν χρησιμοποιείται σε in vivo μελέτη. Εάν η ταιριαστή ένωση ανιχνεύεται in vivo σε ζώα και in vitro σε ανθρώπους, η ταιριαστή χημική οντότητα απομονώνεται ή συντίθεται και κατόπιν δοκιμάζεται περαιτέρω προκειμένου να καθοριστεί η καταλληλότητα της ταιριαστής χημικής οντότητας ώστε να αποτελέσει φάρμακο αγωγής.
CY20161101100T 2008-03-11 2016-10-31 Παραγωγα αζετιδινης και κυκλοβουτανιου ως αναστολεις των jak CY1118176T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3566208P 2008-03-11 2008-03-11
US14498209P 2009-01-15 2009-01-15
PCT/US2009/036635 WO2009114512A1 (en) 2008-03-11 2009-03-10 Azetidine and cyclobutane derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
CY1118176T1 true CY1118176T1 (el) 2017-06-28

Family

ID=40591836

Family Applications (2)

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CY20161101100T CY1118176T1 (el) 2008-03-11 2016-10-31 Παραγωγα αζετιδινης και κυκλοβουτανιου ως αναστολεις των jak
CY2017024C CY2017024I1 (el) 2008-03-11 2017-07-10 Παραγωγα αζετιδινης και κυκλοβουτανιου ως αναστολεις των jak

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Country Status (44)

Country Link
US (3) US8158616B2 (el)
EP (1) EP2288610B8 (el)
JP (2) JP5275371B2 (el)
KR (2) KR101240882B1 (el)
CN (2) CN103788098A (el)
AR (1) AR070828A1 (el)
AU (1) AU2009223640B2 (el)
BR (1) BRPI0909040B8 (el)
CA (1) CA2718271C (el)
CL (1) CL2009000576A1 (el)
CO (1) CO6290658A2 (el)
CY (2) CY1118176T1 (el)
DK (1) DK2288610T3 (el)
DO (2) DOP2010000270A (el)
EA (1) EA017218B1 (el)
EC (1) ECSP10010475A (el)
ES (1) ES2602577T3 (el)
HK (1) HK1149005A1 (el)
HN (1) HN2010001761A (el)
HR (1) HRP20161390T1 (el)
HU (2) HUE029767T2 (el)
IL (1) IL208023A (el)
LT (2) LT2288610T (el)
LU (1) LUC00027I2 (el)
MA (1) MA32219B1 (el)
MX (1) MX2010010012A (el)
MY (1) MY165582A (el)
NL (1) NL300886I2 (el)
NO (1) NO2017033I2 (el)
NZ (1) NZ587928A (el)
PA (1) PA8819201A1 (el)
PE (2) PE20140099A1 (el)
PL (1) PL2288610T3 (el)
PT (1) PT2288610T (el)
RS (1) RS55263B1 (el)
SG (1) SG191660A1 (el)
SI (1) SI2288610T1 (el)
SV (1) SV2010003662A (el)
TN (1) TN2010000415A1 (el)
TW (1) TWI444382B (el)
UA (1) UA101493C2 (el)
UY (1) UY31705A1 (el)
WO (1) WO2009114512A1 (el)
ZA (1) ZA201006000B (el)

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JP5917544B2 (ja) 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン
PL2647629T3 (pl) * 2010-12-01 2015-12-31 Nissan Chemical Ind Ltd Związki pirazolowe o terapeutycznym działaniu na szpiczaka mnogiego
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