CN105294699B - 巴瑞替尼的制备方法 - Google Patents
巴瑞替尼的制备方法 Download PDFInfo
- Publication number
- CN105294699B CN105294699B CN201510880931.XA CN201510880931A CN105294699B CN 105294699 B CN105294699 B CN 105294699B CN 201510880931 A CN201510880931 A CN 201510880931A CN 105294699 B CN105294699 B CN 105294699B
- Authority
- CN
- China
- Prior art keywords
- azetidine
- cyanomethylene
- butyl formate
- pyrrolo
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510880931.XA CN105294699B (zh) | 2015-12-04 | 2015-12-04 | 巴瑞替尼的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510880931.XA CN105294699B (zh) | 2015-12-04 | 2015-12-04 | 巴瑞替尼的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105294699A CN105294699A (zh) | 2016-02-03 |
CN105294699B true CN105294699B (zh) | 2019-06-11 |
Family
ID=55192607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510880931.XA Active CN105294699B (zh) | 2015-12-04 | 2015-12-04 | 巴瑞替尼的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105294699B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2016816A3 (cs) | 2016-12-21 | 2018-07-04 | Zentiva, K.S. | Krystalické formy 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrilu s kyselinou fosforečnou a způsob jejich přípravy |
CN107176955B (zh) * | 2017-03-24 | 2019-04-09 | 南京优科制药有限公司 | 一种巴瑞替尼的制备方法 |
CN108976233A (zh) * | 2017-06-02 | 2018-12-11 | 南京优科生物医药研究有限公司 | 巴瑞替尼的杂质及其制备、检测方法 |
CN107915738B (zh) * | 2017-11-14 | 2019-07-26 | 海化生命(厦门)科技有限公司 | 用于合成巴瑞替尼的关键中间体2的制备方法 |
CN108129482A (zh) * | 2017-12-13 | 2018-06-08 | 江苏中邦制药有限公司 | 一种巴瑞替尼的制备方法 |
US10766900B2 (en) | 2017-12-29 | 2020-09-08 | Formosa Laboratories, Inc. | Baricitinib intermediate, method for forming Baricitinib intermediate, and method for preparing Baricitinib or pharmaceutically acceptable salt thereof |
KR20210137087A (ko) * | 2019-03-05 | 2021-11-17 | 인사이트 코포레이션 | 만성 폐 동종이식 기능장애의 치료를 위한 jak1 경로 억제제 |
CN110256441A (zh) * | 2019-06-24 | 2019-09-20 | 江苏君若医药有限公司 | 一种巴瑞克替尼的制备方法 |
CN113582998A (zh) * | 2021-06-25 | 2021-11-02 | 江苏君若药业有限公司 | 4-(1H-吡唑-4-基)-7H-吡咯[2,3-d]嘧啶的制备 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
CN102985424A (zh) * | 2010-04-14 | 2013-03-20 | 阵列生物制药公司 | 5,7-取代的-咪唑并[1,2-c]嘧啶 |
WO2014138168A1 (en) * | 2013-03-06 | 2014-09-12 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
-
2015
- 2015-12-04 CN CN201510880931.XA patent/CN105294699B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
CN102985424A (zh) * | 2010-04-14 | 2013-03-20 | 阵列生物制药公司 | 5,7-取代的-咪唑并[1,2-c]嘧啶 |
WO2014138168A1 (en) * | 2013-03-06 | 2014-09-12 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
Also Published As
Publication number | Publication date |
---|---|
CN105294699A (zh) | 2016-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105294699B (zh) | 巴瑞替尼的制备方法 | |
CN105884691B (zh) | 一种制备右美托咪定及其中间体的方法 | |
CN107176955A (zh) | 一种巴瑞替尼的制备方法 | |
CN104496979A (zh) | 一种噁唑烷酮类化合物及其中间体的制备方法 | |
CN104592281A (zh) | 双官能团4-tms-5-i-1,2,3-三氮唑类化合物及其制备方法和应用 | |
CN107880079B (zh) | 环状氮杂环双卡宾钯配合物及其制备方法与用途 | |
CN107253912B (zh) | 氰氟草酯的合成方法 | |
CN105017299A (zh) | 一种1,4-二烯基硼化合物的制备方法 | |
JP6547087B1 (ja) | 光学活性な2,3−ビスホスフィノピラジン誘導体、その製造方法、遷移金属錯体及び有機ホウ素化合物の製造方法 | |
JP2023100974A (ja) | トリファロテンならびにその中間体および多形体の調製 | |
CN103539750A (zh) | 一种合成卢非酰胺的工艺 | |
CN103435525B (zh) | 一种制备依折麦布的方法 | |
CN107759565B (zh) | 一种1-三唑-2-丁醇衍生物的制备方法 | |
CN111039767B (zh) | 一种三唑卡宾催化制备氘代醛的方法 | |
CN113121432A (zh) | 一种带有导向基团的脂肪链烯烃的合成方法 | |
CN108586280B (zh) | 合成n′-[(2s,3s)-2-(苄氧基)戊-3-基]甲酰肼的方法 | |
WO2009157386A1 (ja) | 光学活性アミン化合物の製造方法 | |
CN104945434A (zh) | (2﹣二取代膦苯基)-1-烷基-吲哚膦配体及其合成方法和应用 | |
JP6286755B2 (ja) | 新規なジアミン化合物および金属錯体、並びに光学活性化合物の製造方法 | |
CN103113297B (zh) | 一种8-芳基-1-萘酰胺化合物及其制备方法 | |
CN111320664A (zh) | 一种24-胆烯烯酸乙酯的制备方法 | |
CN110475783A (zh) | 阳离子型钌配合物及其制备方法以及其用途 | |
CN114805017B (zh) | 一种2-氟-1,5-己二烯类化合物的制备方法 | |
CN113354625B (zh) | 伏立康唑的合成工艺 | |
CN101602760A (zh) | 一种奥美沙坦酯的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
DD01 | Delivery of document by public notice |
Addressee: SHANGHAI XUNHE PHARMACEUTICAL TECHNOLOGY CO., LTD. Document name: Notification of Passing Examination on Formalities |
|
DD01 | Delivery of document by public notice | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201109 Address after: 570100 Haikou, Meilan District, Hainan Province Shunda Road, No. 6 Patentee after: HAINAN SELECTION PHARMACEUTICAL Co.,Ltd. Address before: 201199, Room 201, building 1B, seven Xin Xin Road, 1366, Shanghai, Minhang District Patentee before: Shanghai Xunhe Pharmaceutical Technology Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20211112 Address after: 201199 Room 201, building 1b, No. 1366, Qishen Road, Minhang District, Shanghai Patentee after: Shanghai Xunhe Pharmaceutical Technology Co., Ltd Address before: 570100 No. 6, Shunda Road, Meilan District, Haikou City, Hainan Province Patentee before: Hainan sailike Pharmaceutical Co., Ltd |
|
TR01 | Transfer of patent right |