CO2020015226A2 - Formas sólidas de un inhibidor de fgfr y procesos para prepararlas - Google Patents

Formas sólidas de un inhibidor de fgfr y procesos para prepararlas

Info

Publication number
CO2020015226A2
CO2020015226A2 CONC2020/0015226A CO2020015226A CO2020015226A2 CO 2020015226 A2 CO2020015226 A2 CO 2020015226A2 CO 2020015226 A CO2020015226 A CO 2020015226A CO 2020015226 A2 CO2020015226 A2 CO 2020015226A2
Authority
CO
Colombia
Prior art keywords
prepare
processes
solid forms
fgfr inhibitor
preparation
Prior art date
Application number
CONC2020/0015226A
Other languages
English (en)
Inventor
William Frietze
Phillip C Liu
Zhongjiang Jia
Qun Li
Ming Tao
Jiacheng Zhou
Dengjin Wang
Timothy C Burn
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CO2020015226A2 publication Critical patent/CO2020015226A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción hace referencia a 3-(2,6-difluoro-3,5-dimetoxifenil)-1-etil-8-(morfolin-4-ilmetil)-1,3,4,7-tetrahidro-2H-pirrolo[3',2':5,6]pirido[4,3-d]pirimidin-2-ona, formas sólidas y polimorfos de estos, métodos para su preparación e intermedios en la preparación de estos, los que son útiles en el tratamiento de las enfermedades mediadas o asociadas a FGFR, tales como el cáncer.
CONC2020/0015226A 2018-05-04 2020-12-03 Formas sólidas de un inhibidor de fgfr y procesos para prepararlas CO2020015226A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862667166P 2018-05-04 2018-05-04
US201962815539P 2019-03-08 2019-03-08
PCT/US2019/030633 WO2019213544A2 (en) 2018-05-04 2019-05-03 Solid forms of an fgfr inhibitor and processes for preparing the same

Publications (1)

Publication Number Publication Date
CO2020015226A2 true CO2020015226A2 (es) 2021-01-18

Family

ID=66554502

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0015226A CO2020015226A2 (es) 2018-05-04 2020-12-03 Formas sólidas de un inhibidor de fgfr y procesos para prepararlas

Country Status (21)

Country Link
US (2) US11466004B2 (es)
EP (2) EP4309737A3 (es)
JP (2) JP2021523121A (es)
KR (1) KR20210018265A (es)
CN (1) CN112867716B (es)
AU (1) AU2019262195B2 (es)
BR (1) BR112020022392A2 (es)
CA (1) CA3099287A1 (es)
CL (1) CL2020002839A1 (es)
CO (1) CO2020015226A2 (es)
CR (1) CR20200590A (es)
DK (1) DK3788047T3 (es)
EC (1) ECSP20078226A (es)
IL (1) IL312465A (es)
MA (1) MA52494A (es)
MX (2) MX2020011718A (es)
PE (1) PE20210920A1 (es)
PH (1) PH12020551850A1 (es)
SG (1) SG11202010636VA (es)
TW (1) TW202003516A (es)
WO (1) WO2019213544A2 (es)

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US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
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CN109776525B (zh) 2013-04-19 2022-01-21 因赛特控股公司 作为fgfr抑制剂的双环杂环
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
AU2016219822B2 (en) 2015-02-20 2020-07-09 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
MX2020011639A (es) 2018-05-04 2021-02-15 Incyte Corp Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclyl heterocycles as fgr suppressors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
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WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2022193227A1 (en) * 2021-03-18 2022-09-22 Nutshell Biotech (Shanghai) Co., Ltd. Fused ring compounds as inhibitors of fgfr tyrosine kinases
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