US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US5156840A
(en)
|
1982-03-09 |
1992-10-20 |
Cytogen Corporation |
Amine-containing porphyrin derivatives
|
US5057313A
(en)
|
1986-02-25 |
1991-10-15 |
The Center For Molecular Medicine And Immunology |
Diagnostic and therapeutic antibody conjugates
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
ES2206447T3
(es)
|
1991-06-14 |
2004-05-16 |
Genentech, Inc. |
Anticuerpo humanizado para heregulina.
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
EP0859841B1
(en)
|
1995-08-18 |
2002-06-19 |
MorphoSys AG |
Protein/(poly)peptide libraries
|
DE19629378A1
(de)
|
1996-07-20 |
1998-01-29 |
Boehringer Ingelheim Kg |
Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
AU743910B2
(en)
*
|
1997-03-24 |
2002-02-07 |
Kyowa Hakko Kirin Co., Ltd. |
{1,2,4}triazolo{1,5-c}pyrimidine derivatives
|
ATE459616T1
(de)
|
1998-08-11 |
2010-03-15 |
Novartis Ag |
Isochinoline derivate mit angiogenesis-hemmender wirkung
|
CA2344828A1
(en)
|
1998-09-22 |
2000-03-30 |
Tomoyuki Kanda |
¬1,2,4|triazolo¬1,5-c|pyrimidine derivatives
|
US6133031A
(en)
|
1999-08-19 |
2000-10-17 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of focal adhesion kinase expression
|
GB9905075D0
(en)
|
1999-03-06 |
1999-04-28 |
Zeneca Ltd |
Chemical compounds
|
WO2000067796A1
(en)
|
1999-05-07 |
2000-11-16 |
Genentech, Inc. |
Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
|
US6808710B1
(en)
|
1999-08-23 |
2004-10-26 |
Genetics Institute, Inc. |
Downmodulating an immune response with multivalent antibodies to PD-1
|
CA2383424C
(en)
|
1999-08-23 |
2011-02-15 |
Gordon Freeman |
Novel b7-4 molecules and uses therefor
|
US6355653B1
(en)
|
1999-09-06 |
2002-03-12 |
Hoffmann-La Roche Inc. |
Amino-triazolopyridine derivatives
|
US6803192B1
(en)
|
1999-11-30 |
2004-10-12 |
Mayo Foundation For Medical Education And Research |
B7-H1, a novel immunoregulatory molecule
|
PT1234031T
(pt)
|
1999-11-30 |
2017-06-26 |
Mayo Foundation |
B7-h1, uma nova molécula imunoregulatória
|
GB0004890D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
CN1437478A
(zh)
|
2000-04-25 |
2003-08-20 |
Idec药物公司 |
瑞图希单抗的鞘内施用,用于中枢神经系统淋巴瘤的治疗
|
CN100384847C
(zh)
|
2000-05-26 |
2008-04-30 |
先灵公司 |
腺苷A2a受体拮抗剂
|
CN1321628C
(zh)
|
2000-06-28 |
2007-06-20 |
史密斯克莱·比奇曼公司 |
湿磨方法
|
CN1446202A
(zh)
*
|
2000-08-11 |
2003-10-01 |
卫材株式会社 |
2-氨基吡啶化合物及其作为药物的用途
|
DE60230482D1
(de)
|
2001-01-17 |
2009-02-05 |
Intreat Pty Ltd |
Antikörper gegen nichtfunktionelle p 2 x 7 rezeptoren, diagnose und behandlung von krebs und anderen leiden
|
AU2002258941A1
(en)
|
2001-04-20 |
2002-11-05 |
Mayo Foundation For Medical Education And Research |
Methods of enhancing cell responsiveness
|
EP1414464A4
(en)
|
2001-05-30 |
2005-06-22 |
Alteon Inc |
METHOD OF TREATING GLAUCOMA
|
CA2448306A1
(en)
|
2001-05-30 |
2002-12-05 |
Alteon Inc. |
Method for treating fibrotic diseases or other indications
|
DE60230890D1
(de)
|
2001-09-19 |
2009-03-05 |
Aventis Pharma Sa |
Indolizine als kinaseproteinhemmer
|
US20030143199A1
(en)
|
2001-10-09 |
2003-07-31 |
Carson Dennis A. |
Use of STAT-6 inhibitors as therapeutic agents
|
IL161156A0
(en)
|
2001-10-30 |
2004-08-31 |
Novartis Ag |
Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
|
WO2003042402A2
(en)
|
2001-11-13 |
2003-05-22 |
Dana-Farber Cancer Institute, Inc. |
Agents that modulate immune cell activation and methods of use thereof
|
US6921762B2
(en)
*
|
2001-11-16 |
2005-07-26 |
Amgen Inc. |
Substituted indolizine-like compounds and methods of use
|
AR038366A1
(es)
*
|
2001-11-30 |
2005-01-12 |
Schering Corp |
Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
|
WO2003062236A1
(en)
|
2002-01-22 |
2003-07-31 |
Warner-Lambert Company Llc |
2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES
|
JPWO2003068776A1
(ja)
|
2002-02-15 |
2005-06-02 |
協和醗酵工業株式会社 |
[1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体
|
PE20040522A1
(es)
|
2002-05-29 |
2004-09-28 |
Novartis Ag |
Derivados de diarilurea dependientes de la cinasa de proteina
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
JPWO2004029056A1
(ja)
*
|
2002-09-24 |
2006-01-26 |
協和醗酵工業株式会社 |
[1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体
|
AR042052A1
(es)
|
2002-11-15 |
2005-06-08 |
Vertex Pharma |
Diaminotriazoles utiles como inhibidores de proteinquinasas
|
UA80767C2
(en)
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
JP4511943B2
(ja)
|
2002-12-23 |
2010-07-28 |
ワイス エルエルシー |
Pd−1に対する抗体およびその使用
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
AU2004205631A1
(en)
|
2003-01-16 |
2004-08-05 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
US20050008625A1
(en)
|
2003-02-13 |
2005-01-13 |
Kalobios, Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2004079013A1
(en)
|
2003-03-03 |
2004-09-16 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
TWI344955B
(en)
|
2003-03-14 |
2011-07-11 |
Ono Pharmaceutical Co |
Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
|
AR043633A1
(es)
|
2003-03-20 |
2005-08-03 |
Schering Corp |
Ligandos de receptores de canabinoides
|
US7834014B2
(en)
|
2003-04-09 |
2010-11-16 |
Biogen Idec Ma Inc. |
A2a adenosine receptor antagonists
|
US20070010522A1
(en)
*
|
2003-04-09 |
2007-01-11 |
Chi Vu |
Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
|
US7674791B2
(en)
|
2003-04-09 |
2010-03-09 |
Biogen Idec Ma Inc. |
Triazolopyrazines and methods of making and using the same
|
ES2322267T3
(es)
|
2003-04-09 |
2009-06-18 |
Genentech, Inc. |
Terapia de una enfermedad autoinmunologica en un paciente que presenta una respuesta inadecuada a un inhibidor de tnf-alfa.
|
CA2528710C
(en)
|
2003-06-10 |
2012-04-17 |
Kyowa Hakko Kogyo Co., Ltd. |
A method of treating an anxiety disorder
|
DE602004029252D1
(de)
|
2003-06-13 |
2010-11-04 |
Biogen Idec Inc |
Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen
|
ATE456558T1
(de)
|
2003-08-14 |
2010-02-15 |
Hoffmann La Roche |
Gabanerge modulatoren
|
CN1871259A
(zh)
|
2003-08-22 |
2006-11-29 |
比奥根艾迪克Ma公司 |
具有改变的效应物功能的经改进的抗体和制备它的方法
|
WO2005020921A2
(en)
|
2003-08-29 |
2005-03-10 |
Exelixis, Inc. |
C-kit modulators and methods of use
|
PE20050952A1
(es)
|
2003-09-24 |
2005-12-19 |
Novartis Ag |
Derivados de isoquinolina como inhibidores de b-raf
|
GB0403819D0
(en)
|
2004-02-20 |
2004-03-24 |
Merck Sharp & Dohme |
New compounds
|
EP1737459B1
(en)
|
2004-03-19 |
2009-08-05 |
Warner-Lambert Company LLC |
Imidazopyridine and imidazopyrimidine derivatives as antibacterial agents
|
US7306631B2
(en)
|
2004-03-30 |
2007-12-11 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
WO2005118555A1
(en)
|
2004-06-04 |
2005-12-15 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
EP1912643A2
(en)
|
2004-06-23 |
2008-04-23 |
Idenix (Cayman) Limited |
5-aza-7-deazapurine derivatives for treating infections with flaviviridae
|
US20050288502A1
(en)
|
2004-06-25 |
2005-12-29 |
Andersen Denise L |
Substituted heterocyclic compounds and methods of use
|
US7713973B2
(en)
|
2004-10-15 |
2010-05-11 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
AU2005295579B2
(en)
|
2004-10-15 |
2011-08-04 |
NortonLifeLock Inc. |
One time password
|
US20060211739A1
(en)
|
2005-02-08 |
2006-09-21 |
Arturo Perez-Medrano |
Use of selective P2X7 receptor antagonists
|
LT2439273T
(lt)
|
2005-05-09 |
2019-05-10 |
Ono Pharmaceutical Co., Ltd. |
Žmogaus monokloniniai antikūnai prieš programuotos mirties 1(pd-1) baltymą, ir vėžio gydymo būdai, naudojant vien tik anti-pd-1 antikūnus arba derinyje su kitais imunoterapiniais vaistais
|
KR20080025066A
(ko)
|
2005-05-18 |
2008-03-19 |
바이오겐 아이덱 인크. |
섬유성 상태의 치료 방법
|
JPWO2006129626A1
(ja)
|
2005-05-30 |
2009-01-08 |
協和醗酵工業株式会社 |
[1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体の製造法
|
ATE556712T1
(de)
|
2005-06-07 |
2012-05-15 |
Kyowa Hakko Kirin Co Ltd |
A2a antagonisten zur behandlung von motorischen störungen
|
US7452892B2
(en)
|
2005-06-17 |
2008-11-18 |
Bristol-Myers Squibb Company |
Triazolopyrimidine cannabinoid receptor 1 antagonists
|
JP4986451B2
(ja)
|
2005-06-30 |
2012-07-25 |
信一郎 礒部 |
マーキング剤
|
CN105330741B
(zh)
|
2005-07-01 |
2023-01-31 |
E.R.施贵宝&圣斯有限责任公司 |
抗程序性死亡配体1(pd-l1)的人单克隆抗体
|
WO2007011759A2
(en)
|
2005-07-15 |
2007-01-25 |
Kalypsys, Inc. |
Inhibitors of mitotic kinesin
|
EP1928237A4
(en)
|
2005-09-02 |
2011-03-09 |
Abbott Lab |
NEW HETEROCYCLES BASED ON IMIDAZO
|
RU2008122967A
(ru)
|
2005-11-10 |
2009-12-20 |
Шеринг Корпорейшн (US) |
Имидазопиразины в качестве ингибиторов протеинкиназ
|
JP5335432B2
(ja)
|
2005-11-17 |
2013-11-06 |
オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー |
縮合2環系mTOR阻害剤
|
EP2010505B1
(en)
|
2006-03-28 |
2012-12-05 |
Atir Holding S.A. |
Heterocyclic compounds and uses thereof in the treatment of sexual disorders
|
DE602007006010D1
(de)
|
2006-05-31 |
2010-06-02 |
Galapagos Nv |
Triazolopyrazinverbindungen zur behandlung von degenerations- und entzündungskrankheiten
|
ATE522518T1
(de)
|
2006-05-31 |
2011-09-15 |
Takeda San Diego Inc |
Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
|
EP2044074A2
(en)
|
2006-06-23 |
2009-04-08 |
Incyte Corporation |
Purinone derivatives as hm74a agonists
|
ES2436028T3
(es)
|
2006-06-23 |
2013-12-26 |
Radius Health, Inc. |
Tratamiento de síntomas vasomotores con moduladores selectivos de receptores de estrógeno
|
JP5382692B2
(ja)
|
2006-07-10 |
2014-01-08 |
学校法人藤田学園 |
抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途
|
US20080021217A1
(en)
|
2006-07-20 |
2008-01-24 |
Allen Borchardt |
Heterocyclic inhibitors of rho kinase
|
DE102006041292A1
(de)
|
2006-09-01 |
2008-03-06 |
Henkel Kgaa |
Wasserstoffperoxid-Aktivierung mit N-Heterocyclen
|
WO2008037607A1
(de)
|
2006-09-25 |
2008-04-03 |
Basf Se |
Carbonylgruppen-enthaltende heterocyclische verbindungen und deren verwendung zur bekämpfung von phytopathogenen pilzen
|
WO2008056176A1
(en)
|
2006-11-10 |
2008-05-15 |
Scottish Biomedical Limited |
Pyrazolopyrimidines as phosphodiesterase inhibitors
|
JP2010511721A
(ja)
|
2006-12-05 |
2010-04-15 |
ナショナル チャオ トン ユニバーシティ |
インダゾール化合物
|
DE102007012645A1
(de)
|
2007-03-16 |
2008-09-18 |
Bayer Healthcare Ag |
Substituierte Imidazo- und Triazolopyrimidine
|
JP2010523668A
(ja)
|
2007-04-10 |
2010-07-15 |
ハー・ルンドベック・アクチエゼルスカベット |
P2x7拮抗薬としてのヘテロアリールアミド類似体
|
US8039505B2
(en)
|
2007-04-11 |
2011-10-18 |
University Of Utah Research Foundation |
Compounds for modulating T-cells
|
PT2155747E
(pt)
|
2007-05-10 |
2012-12-19 |
Ge Healthcare Ltd |
Imidazol(1,2-a)piridinas e compostos relacionados com actividade nos receptores de canabinóides cb2
|
WO2008138843A1
(en)
|
2007-05-10 |
2008-11-20 |
Galapagos N.V. |
Imidazopyridines and triazolopyrimidines useful for the treatment of joint degenerative & inflammatory diseases
|
HUP0700395A2
(en)
|
2007-06-07 |
2009-03-02 |
Sanofi Aventis |
Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
|
DK2170959T3
(da)
|
2007-06-18 |
2014-01-13 |
Merck Sharp & Dohme |
Antistoffer mod human programmeret dødsreceptor pd-1
|
EA201000130A1
(ru)
|
2007-07-18 |
2010-08-30 |
Новартис Аг |
Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
JP2010535773A
(ja)
|
2007-08-10 |
2010-11-25 |
グラクソスミスクライン エルエルシー |
ウイルス感染を治療するための窒素含有二環式化学物質
|
US8062852B2
(en)
|
2007-10-01 |
2011-11-22 |
The Children's Hospital And Regional Medical Center |
Detection and treatment of autoimmune disorders
|
GB0719803D0
(en)
|
2007-10-10 |
2007-11-21 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
WO2009050228A2
(en)
|
2007-10-18 |
2009-04-23 |
Novartis Ag |
Csf-1r inhibitors for treatment of cancer and bone diseases
|
US20090118301A1
(en)
|
2007-11-02 |
2009-05-07 |
Arbor Vita Corporation |
Compositions and Methods for Treating Cancer
|
CA2704645A1
(en)
|
2007-11-09 |
2009-05-14 |
The Salk Institute For Biological Studies |
Non-nucleoside reverse transcriptase inhibitors
|
PE20091074A1
(es)
|
2007-12-13 |
2009-07-26 |
Bayer Healthcare Ag |
Triazolotriazinas y triazolopirazinas y su uso
|
EA201001030A1
(ru)
|
2007-12-19 |
2011-02-28 |
Амген Инк. |
Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла
|
EP2231661A1
(en)
|
2007-12-19 |
2010-09-29 |
Amgen, Inc. |
Inhibitors of pi3 kinase
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
US8637542B2
(en)
|
2008-03-14 |
2014-01-28 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
WO2009117421A2
(en)
|
2008-03-17 |
2009-09-24 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
EP2546387A1
(en)
|
2008-03-21 |
2013-01-16 |
Enthone, Inc. |
Adhesion promotion of metal to laminate with a multi-functional compound
|
US20090281089A1
(en)
|
2008-04-11 |
2009-11-12 |
Genentech, Inc. |
Pyridyl inhibitors of hedgehog signalling
|
WO2009128520A1
(ja)
|
2008-04-18 |
2009-10-22 |
塩野義製薬株式会社 |
P13k阻害活性を有する複素環化合物
|
TWI473614B
(zh)
|
2008-05-29 |
2015-02-21 |
Kyowa Hakko Kirin Co Ltd |
Anti-analgesic inhibitors
|
CA2731573C
(en)
|
2008-07-23 |
2018-09-18 |
Kyowa Hakko Kirin Co., Ltd. |
Selective adenosine a2a receptor antagonists useful in the treatment and prevention of migraine
|
EP2345328A4
(en)
|
2008-09-19 |
2014-06-25 |
Sumitomo Chemical Co |
COMPOSITION FOR USE IN AGRICULTURE
|
US20120021519A1
(en)
|
2008-09-19 |
2012-01-26 |
Presidents And Fellows Of Harvard College |
Efficient induction of pluripotent stem cells using small molecule compounds
|
ES2592216T3
(es)
|
2008-09-26 |
2016-11-28 |
Dana-Farber Cancer Institute, Inc. |
Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
|
SI2376535T1
(sl)
|
2008-12-09 |
2017-07-31 |
F. Hoffmann-La Roche Ag |
Protitelesa anti-pd-l1 in njihova uporaba za izboljšanje funkcije celic t
|
JO2885B1
(en)
|
2008-12-22 |
2015-03-15 |
ايلي ليلي اند كومباني |
Protein kinase inhibitors
|
JP2012513410A
(ja)
|
2008-12-23 |
2012-06-14 |
アボット・ラボラトリーズ |
抗ウイルス化合物
|
RU2505540C2
(ru)
|
2008-12-23 |
2014-01-27 |
Эббви Инк. |
Антивирусные соединения
|
EP2210891A1
(en)
|
2009-01-26 |
2010-07-28 |
Domain Therapeutics |
New adenosine receptor ligands and uses thereof
|
JP5844159B2
(ja)
|
2009-02-09 |
2016-01-13 |
ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille |
Pd−1抗体およびpd−l1抗体ならびにその使用
|
WO2010104306A2
(ko)
|
2009-03-07 |
2010-09-16 |
주식회사 메디젠텍 |
세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
|
WO2011019780A1
(en)
|
2009-08-11 |
2011-02-17 |
Bristol-Myers Squibb Company |
Azaindazoles as btk kinase modulators and use thereof
|
JP5819831B2
(ja)
|
2009-08-17 |
2015-11-24 |
インテリカイン, エルエルシー |
複素環式化合物およびそれらの使用
|
EP2509983B1
(en)
|
2009-11-16 |
2014-09-17 |
Merck Sharp & Dohme Corp. |
FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY
|
JP2013512251A
(ja)
|
2009-11-24 |
2013-04-11 |
アンプリミューン、インコーポレーテッド |
Pd−l1/pd−l2の同時阻害
|
WO2011078143A1
(ja)
|
2009-12-22 |
2011-06-30 |
塩野義製薬株式会社 |
ピリミジン誘導体およびそれらを含有する医薬組成物
|
WO2011082400A2
(en)
|
2010-01-04 |
2011-07-07 |
President And Fellows Of Harvard College |
Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
|
EP2347769A1
(en)
|
2010-01-20 |
2011-07-27 |
Glycotope GmbH |
Cancer stem cell markers and uses thereof
|
US20110190269A1
(en)
|
2010-02-01 |
2011-08-04 |
Karlheinz Baumann |
Gamma secretase modulators
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
TW201200518A
(en)
|
2010-03-10 |
2012-01-01 |
Kalypsys Inc |
Heterocyclic inhibitors of histamine receptors for the treatment of disease
|
SG184073A1
(en)
|
2010-03-18 |
2012-10-30 |
Pasteur Institut Korea |
Anti-infective compounds
|
UY33304A
(es)
|
2010-04-02 |
2011-10-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
GB201007187D0
(en)
|
2010-04-29 |
2010-06-09 |
Iti Scotland Ltd |
Ubiquitination modulators
|
WO2011153588A1
(en)
|
2010-06-10 |
2011-12-15 |
Biota Scientific Management Pty Ltd |
Viral polymerase inhibitors
|
US20120083498A1
(en)
|
2010-06-17 |
2012-04-05 |
Fatah Kashanchi |
Modulators of Viral Transcription, and Methods and Compositions Therewith
|
JP2013532153A
(ja)
|
2010-06-18 |
2013-08-15 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
AU2011295440B2
(en)
|
2010-08-27 |
2015-06-11 |
Merck Patent Gmbh |
Triazolopyrazine derivatives
|
SI2632467T1
(sl)
|
2010-10-25 |
2016-10-28 |
G1 Therapeutics, Inc. |
Inhibitorji CDK
|
CN103298460B
(zh)
|
2010-12-14 |
2016-06-01 |
电泳有限公司 |
酪蛋白激酶1δ(CK1δ)抑制剂
|
US8765760B2
(en)
|
2011-01-11 |
2014-07-01 |
Sunovion Pharmaceuticals, Inc. |
[1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
DK2688887T3
(en)
|
2011-03-23 |
2015-06-29 |
Amgen Inc |
DEHYDRATED tricyclic DUALINHIBITORER OF CDK 4/6 AND FLT3
|
US9029389B2
(en)
|
2011-04-21 |
2015-05-12 |
Institut Pasteur Korea |
Anti-inflammation compounds
|
WO2012147890A1
(ja)
|
2011-04-27 |
2012-11-01 |
持田製薬株式会社 |
新規アゾール誘導体
|
DE102011111400A1
(de)
|
2011-08-23 |
2013-02-28 |
Merck Patent Gmbh |
Bicyclische heteroaromatische Verbindungen
|
EP2604265A1
(en)
|
2011-12-17 |
2013-06-19 |
Royal College of Surgeons in Ireland (RCSI) |
P2x7 antagonists as frontline or adjunctive treatment against status epilepticus
|
WO2013106254A1
(en)
|
2012-01-11 |
2013-07-18 |
Dow Agrosciences Llc |
Pesticidal compositions and processes related thereto
|
EA201492069A1
(ru)
|
2012-05-30 |
2015-03-31 |
Ф.Хоффманн-Ля Рош Аг |
Соединения триазола в качестве ингибиторов фосфодиэстеразы 10 (pde10)
|
BR112014030147B1
(pt)
|
2012-06-22 |
2019-10-15 |
Sumitomo Chemical Company, Limited |
Compostos heterocíclicos fundidos, composição e método para controlar pestes
|
CA2880299A1
(en)
|
2012-07-27 |
2014-01-30 |
Bial - Portela & Ca, S.A. |
Process for the synthesis of substituted urea compounds
|
EP2919770A4
(en)
|
2012-11-14 |
2017-03-08 |
The Board of Regents of The University of Texas System |
Inhibition of hif-2 heterodimerization with hif1 (arnt)
|
WO2014126580A1
(en)
|
2013-02-15 |
2014-08-21 |
Dow Agrosciences Llc |
Pesticidal compositions and processes related thereto
|
EP2968304B1
(en)
|
2013-03-14 |
2018-10-10 |
The Trustees of Columbia University in the City of New York |
4-phenylpiperidines, their preparation and use
|
US9090697B2
(en)
|
2013-03-15 |
2015-07-28 |
Bayer Healthcare Llc |
Methods for treating bleeding disorders
|
WO2014153424A1
(en)
|
2013-03-19 |
2014-09-25 |
La Jolla Institute For Allergy And Immunology |
Reducing diabetes in patients receiving hmg-coa reductase inhibitors (statins)
|
BR112016001457A2
(pt)
|
2013-07-25 |
2017-08-29 |
Dana Farber Cancer Inst Inc |
Inibidores de fatores de transcrição e usos dos mesmos
|
WO2015157955A1
(en)
|
2014-04-17 |
2015-10-22 |
Abbvie Inc. |
Heterocyclic btk inhibit ors
|
WO2016007722A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as lsd1 inhibitors
|
EP3166974A1
(en)
|
2014-07-11 |
2017-05-17 |
Genentech, Inc. |
Anti-pd-l1 antibodies and diagnostic uses thereof
|
CN107106546A
(zh)
|
2014-10-06 |
2017-08-29 |
弗拉特利发现实验室有限责任公司 |
三唑并吡啶化合物和用于治疗囊性纤维化的方法
|
US20180030144A1
(en)
|
2014-10-10 |
2018-02-01 |
Innate Pharma |
Cd73 blockade
|
US10766966B2
(en)
|
2014-10-10 |
2020-09-08 |
Innate Pharma |
CD73 blockade
|
AU2015345202B2
(en)
|
2014-11-10 |
2021-05-13 |
Medimmune Limited |
Binding molecules specific for CD73 and uses thereof
|
JP6847037B2
(ja)
|
2014-11-11 |
2021-03-24 |
メディミューン リミテッド |
抗cd73抗体とa2a受容体阻害薬とを含む併用治療薬及びその使用
|
RS60631B1
(sr)
|
2014-11-21 |
2020-09-30 |
Bristol Myers Squibb Co |
Antitela protiv cd73 i njihova upotreba
|
HUE057027T2
(hu)
|
2015-02-12 |
2022-04-28 |
Nissan Chemical Corp |
Kondenzált heterociklusos vegyületek és peszticidek
|
ES2838977T3
(es)
|
2015-03-06 |
2021-07-02 |
Pharmakea Inc |
Inhibidores de la lisil oxidasa fluorada tipo 2 y usos de los mismos
|
TWI714567B
(zh)
|
2015-04-03 |
2021-01-01 |
美商英塞特公司 |
作為lsd1抑制劑之雜環化合物
|
KR20180034588A
(ko)
|
2015-07-30 |
2018-04-04 |
마크로제닉스, 인크. |
Pd-1-결합 분자 및 그것의 사용 방법
|
EP3362475B1
(en)
|
2015-10-12 |
2023-08-30 |
Innate Pharma |
Cd73 blocking agents
|
WO2017070089A1
(en)
|
2015-10-19 |
2017-04-27 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
EP4141002A1
(en)
|
2015-11-19 |
2023-03-01 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
EP3387442A4
(en)
|
2015-12-09 |
2019-05-08 |
Corvus Pharmaceuticals, Inc. |
HUMANIZED ANTI-CD73 ANTIBODIES
|
MA44075A
(fr)
|
2015-12-17 |
2021-05-19 |
Incyte Corp |
Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1
|
PL3394033T3
(pl)
|
2015-12-22 |
2021-05-31 |
Incyte Corporation |
Związki heterocykliczne jako immunomodulatory
|
KR20180103918A
(ko)
|
2015-12-24 |
2018-09-19 |
코버스 파마슈티칼스, 인크. |
암을 치료하는 방법
|
CO2018008799A2
(es)
|
2016-02-24 |
2018-09-20 |
Pfizer |
Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de jak
|
EP3429591B1
(en)
|
2016-03-16 |
2023-03-15 |
Kura Oncology, Inc. |
Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
|
TW201808950A
(zh)
|
2016-05-06 |
2018-03-16 |
英塞特公司 |
作為免疫調節劑之雜環化合物
|
MA45116A
(fr)
|
2016-05-26 |
2021-06-02 |
Incyte Corp |
Composés hétérocycliques comme immunomodulateurs
|
MX2018016273A
(es)
|
2016-06-20 |
2019-07-04 |
Incyte Corp |
Compuestos heterociclicos como inmunomoduladores.
|
WO2017223414A1
(en)
*
|
2016-06-24 |
2017-12-28 |
Incyte Corporation |
HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS
|
WO2018004478A1
(en)
|
2016-06-29 |
2018-01-04 |
Hayat Kimya San. A. Ş. |
An improved method of soft nonwoven fabric production
|
WO2018013611A1
(en)
|
2016-07-11 |
2018-01-18 |
Corvus Pharmaceuticals, Inc. |
Anti-cd73 antibodies
|
EP3484866B1
(en)
|
2016-07-14 |
2022-09-07 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
MA46045A
(fr)
|
2016-08-29 |
2021-04-28 |
Incyte Corp |
Composés hétérocycliques utilisés comme immunomodulateurs
|
SG11201901729YA
(en)
|
2016-09-02 |
2019-03-28 |
Ironwood Pharmaceuticals Inc |
Fused bicyclic sgc stimulators
|
KR20190091281A
(ko)
|
2016-12-13 |
2019-08-05 |
아스텔라스세이야쿠 가부시키가이샤 |
항인간 cd73 항체
|
CN110582493B
(zh)
|
2016-12-22 |
2024-03-08 |
因赛特公司 |
作为免疫调节剂的苯并噁唑衍生物
|
EP3558989B1
(en)
|
2016-12-22 |
2021-04-14 |
Incyte Corporation |
Triazolo[1,5-a]pyridine derivatives as immunomodulators
|
WO2018119286A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Bicyclic heteroaromatic compounds as immunomodulators
|
ES2899402T3
(es)
|
2016-12-22 |
2022-03-11 |
Incyte Corp |
Derivados de piridina como inmunomoduladores
|
MD3558990T2
(ro)
|
2016-12-22 |
2023-02-28 |
Incyte Corp |
Derivați tetrahidro imidazo[4,5-c]piridină ca inductori de internalizare a PD-L1
|
WO2018119263A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds derivatives as pd-l1 internalization inducers
|
CN110446709B
(zh)
|
2017-01-23 |
2023-09-12 |
锐新医药公司 |
作为变构shp2抑制剂的二环化合物
|
CN109476755B
(zh)
|
2017-01-24 |
2020-12-04 |
天境生物科技(上海)有限公司 |
Cd73抗体及其用途
|
CN109963854B
(zh)
*
|
2017-03-16 |
2022-04-12 |
江苏恒瑞医药股份有限公司 |
杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
|
EP3606962A4
(en)
|
2017-04-04 |
2020-12-23 |
Corvus Pharmaceuticals, Inc. |
TREATMENT METHODS FOR HIGH CD73 TUMORS
|
JP7065113B2
(ja)
*
|
2017-04-07 |
2022-05-11 |
南京明徳新薬研発有限公司 |
A2A受容体阻害剤としての[1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体
|
CA3063344A1
(en)
|
2017-05-23 |
2018-11-29 |
Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) |
Novel cd73 antibody, preparation and uses thereof
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
JP7433910B2
(ja)
|
2017-06-22 |
2024-02-20 |
ノバルティス アーゲー |
Cd73に対する抗体分子及びその使用
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
|
WO2019002606A1
(en)
|
2017-06-30 |
2019-01-03 |
Selvita S.A. |
ADENOSINE A2A RECEPTOR 5,6-BICYCLO-IMIDAZO [1,2-A] PYRAZINE MODULATORS
|
CN109535161B
(zh)
*
|
2017-09-22 |
2021-09-03 |
江苏恒瑞医药股份有限公司 |
三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
|
CR20200173A
(es)
|
2017-10-24 |
2020-06-26 |
Bayer Pharma AG |
Amidas de imidazopiridina sustituidas y su uso
|
JP2021503478A
(ja)
|
2017-11-16 |
2021-02-12 |
ノバルティス アーゲー |
組み合わせ治療
|
PE20211455A1
(es)
|
2018-01-31 |
2021-08-05 |
Aptinyx Inc |
Moduladores del receptor nmda espiro-lactama y usos de los mismos
|
US11578072B2
(en)
|
2018-01-31 |
2023-02-14 |
Aptinyx Inc. |
Spiro-lactam NMDA receptor modulators and uses thereof
|
JOP20200197A1
(ar)
|
2018-02-17 |
2020-08-16 |
Astrazeneca Ab |
مثبطات أرجيناز وطرق لاستخدامها
|
PE20211001A1
(es)
|
2018-02-27 |
2021-06-01 |
Incyte Corp |
Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b
|
WO2019170131A1
(zh)
|
2018-03-07 |
2019-09-12 |
复旦大学 |
靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途
|
CR20200392A
(es)
|
2018-03-09 |
2020-11-17 |
Agenus Inc |
Anticuerpos anti-cd73 y métodos de uso de los mismos
|
CN111867628A
(zh)
|
2018-03-09 |
2020-10-30 |
东莞凡恩世生物医药有限公司 |
抗cd73抗体及其用途
|
SG11202009440WA
(en)
|
2018-03-30 |
2020-10-29 |
Incyte Corp |
Heterocyclic compounds as immunomodulators
|
US11220510B2
(en)
|
2018-04-09 |
2022-01-11 |
Incyte Corporation |
Pyrrole tricyclic compounds as A2A / A2B inhibitors
|
CA3096674A1
(en)
|
2018-04-12 |
2019-10-17 |
Bristol-Myers Squibb Company |
Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody
|
DK3790877T3
(da)
|
2018-05-11 |
2023-04-24 |
Incyte Corp |
Tetrahydro-imidazo[4,5-c]pyridinderivater som pd-l1-immunmodulatorer
|
JP7391046B2
(ja)
|
2018-05-18 |
2023-12-04 |
インサイト・コーポレイション |
A2a/a2b阻害剤としての縮合ピリミジン誘導体
|
MX2020014158A
(es)
|
2018-06-20 |
2021-04-12 |
Incyte Corp |
Anticuerpos anti proteína de muerte programada 1 (pd-1) y usos de estos.
|
GEP20237560B
(en)
|
2018-07-05 |
2023-10-25 |
Incyte Corp |
Fused pyrazine derivatives as a2a / a2b inhibitors
|
JP2021533093A
(ja)
|
2018-08-13 |
2021-12-02 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
モノアシルグリセロールリパーゼ阻害剤としての新規複素環化合物
|
AU2019322538B2
(en)
|
2018-08-13 |
2021-09-30 |
F. Hoffmann-La Roche Ag |
New heterocyclic compounds as monoacylglycerol lipase inhibitors
|
KR20210049120A
(ko)
|
2018-08-22 |
2021-05-04 |
아스트라제네카 아베 |
아르기나제 저해제 및 이의 사용 방법
|
GB201813678D0
(en)
|
2018-08-22 |
2018-10-03 |
Keybioscience Ag |
Acylated calcitonin mimetics
|
AR116315A1
(es)
|
2018-09-12 |
2021-04-21 |
Dizal Jiangsu Pharmaceutical Co Ltd |
Compuestos de triazolo-pirimidina y usos de los mismos
|
EP3856173A4
(en)
|
2018-09-26 |
2022-07-06 |
Kura Oncology, Inc. |
TREATMENT OF HEMATOLOGICAL MALIGNITIES WITH MENIN INHIBITORS
|
WO2020073945A1
(zh)
|
2018-10-10 |
2020-04-16 |
江苏豪森药业集团有限公司 |
双环类衍生物抑制剂、其制备方法和应用
|
AR117188A1
(es)
|
2018-11-02 |
2021-07-21 |
Aicuris Gmbh & Co Kg |
Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
|
US20220040184A1
(en)
|
2018-11-20 |
2022-02-10 |
Merck Sharp Dohme Corp. |
Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
|
TWI741423B
(zh)
|
2018-11-30 |
2021-10-01 |
大陸商江蘇豪森藥業集團有限公司 |
雜芳類衍生物調節劑、其製備方法和應用
|
TWI829857B
(zh)
|
2019-01-29 |
2024-01-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
|
WO2021030162A1
(en)
|
2019-08-09 |
2021-02-18 |
Incyte Corporation |
Salts of a pd-1/pd-l1 inhibitor
|
AU2020337350A1
(en)
|
2019-08-26 |
2022-03-10 |
Incyte Corporation |
Triazolopyrimidines as A2A / A2B inhibitors
|
US11401279B2
(en)
|
2019-09-30 |
2022-08-02 |
Incyte Corporation |
Pyrido[3,2-d]pyrimidine compounds as immunomodulators
|
TW202120504A
(zh)
|
2019-11-11 |
2021-06-01 |
美商英塞特公司 |
Pd-1/pd-l1 抑制劑之鹽及結晶型
|
CA3166533A1
(en)
|
2020-01-03 |
2021-07-08 |
Incyte Corporation |
Anti-cd73 antibodies and uses thereof
|
EP4085060A1
(en)
|
2020-01-03 |
2022-11-09 |
Incyte Corporation |
Combination therapy comprising a2a/a2b and pd-1/pd-l1 inhibitors
|
AU2021373044A1
(en)
|
2020-11-06 |
2023-06-08 |
Incyte Corporation |
Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof
|
TW202233615A
(zh)
|
2020-11-06 |
2022-09-01 |
美商英塞特公司 |
Pd—1/pd—l1抑制劑之結晶形式
|
WO2022099018A1
(en)
|
2020-11-06 |
2022-05-12 |
Incyte Corporation |
Process of preparing a pd-1/pd-l1 inhibitor
|
CA3207066A1
(en)
|
2020-12-29 |
2022-07-07 |
Incyte Corporation |
Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies
|