CA3192925A1 - Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments - Google Patents

Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Info

Publication number
CA3192925A1
CA3192925A1 CA3192925A CA3192925A CA3192925A1 CA 3192925 A1 CA3192925 A1 CA 3192925A1 CA 3192925 A CA3192925 A CA 3192925A CA 3192925 A CA3192925 A CA 3192925A CA 3192925 A1 CA3192925 A1 CA 3192925A1
Authority
CA
Canada
Prior art keywords
antigen
cov
seq
acid sequence
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3192925A
Other languages
English (en)
French (fr)
Inventor
Robert Babb
Alina Baum
Gang Chen
Cindy Gerson
Johanna Hansen
Tammy Huang
Christos Kyratsous
Wen-Yi Lee
Marine Malbec
Andrew Murphy
William Olson
Neil Stahl
George D. Yancopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3192925A1 publication Critical patent/CA3192925A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA3192925A 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments Pending CA3192925A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063004312P 2020-04-02 2020-04-02
US63/004,312 2020-04-02
US202063014687P 2020-04-23 2020-04-23
US63/014,687 2020-04-23
US202063025949P 2020-05-15 2020-05-15
US63/025,949 2020-05-15
US202063034865P 2020-06-04 2020-06-04
US63/034,865 2020-06-04
CA3115553A CA3115553C (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3115553A Division CA3115553C (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Publications (1)

Publication Number Publication Date
CA3192925A1 true CA3192925A1 (en) 2021-03-11

Family

ID=72614999

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3192925A Pending CA3192925A1 (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
CA3115553A Active CA3115553C (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3115553A Active CA3115553C (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

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US (5) US10787501B1 (enExample)
EP (2) EP4209507A1 (enExample)
JP (4) JP7116256B1 (enExample)
KR (2) KR102831970B1 (enExample)
CN (1) CN113766928B (enExample)
AU (1) AU2020340881B2 (enExample)
CA (2) CA3192925A1 (enExample)
CL (2) CL2021000997A1 (enExample)
CO (1) CO2021005072A2 (enExample)
CR (1) CR20220552A (enExample)
DK (1) DK3889177T5 (enExample)
ES (1) ES2939895T3 (enExample)
FI (1) FI3889177T3 (enExample)
HR (1) HRP20230338T1 (enExample)
HU (1) HUE061425T2 (enExample)
IL (1) IL282060A (enExample)
LT (1) LT3889177T (enExample)
MA (1) MA54405B1 (enExample)
MX (1) MX2021004130A (enExample)
MY (1) MY197648A (enExample)
PE (1) PE20221893A1 (enExample)
PH (1) PH12021550793A1 (enExample)
PL (1) PL3889177T3 (enExample)
PT (1) PT3889177T (enExample)
RS (1) RS64105B1 (enExample)
SG (1) SG11202103404PA (enExample)
SI (1) SI3889177T1 (enExample)
SM (1) SMT202300061T1 (enExample)
TW (2) TWI858423B (enExample)
WO (1) WO2021045836A1 (enExample)

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986704B2 (en) 2012-07-06 2015-03-24 Valneva Austria Gmbh Mutant fragments of OspA and methods and uses relating thereto
WO2014159990A1 (en) 2013-03-13 2014-10-02 Yale University Interferon production using short rna duplexes
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
US12018054B2 (en) 2017-04-13 2024-06-25 Valneva Austria Gmbh Multivalent OspA polypeptides and methods and uses relating thereto
KR20210137485A (ko) 2019-04-05 2021-11-17 아카데미아 시니카 시알리다제-내성 당류 및 이의 제조 및 사용 방법
CN114787928A (zh) 2019-11-12 2022-07-22 雷杰纳荣制药公司 用于鉴定、分类和/或排序遗传序列的方法和系统
WO2021138721A1 (en) * 2020-01-09 2021-07-15 The University Of Queensland Self-assembling, self-adjuvanting system for delivery of vaccines
TWI859420B (zh) * 2020-02-26 2024-10-21 美商維爾生物科技股份有限公司 抗sars-cov-2抗體及使用其之方法
AU2021230334A1 (en) * 2020-03-05 2022-09-29 New York Blood Center, Inc. Immunogenic compositions against severe acute respiratory syndrome coronavirus 2
US11365239B2 (en) * 2020-03-20 2022-06-21 Tsb Therapeutics (Beijing) Co., Ltd. Anti-SARS-COV-2 antibodies and uses thereof
WO2021190980A1 (en) * 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
WO2021194891A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from cr3022
WO2021194951A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 2dd8
WO2021194985A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 6nb6
WO2021194896A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 2ghw
WO2021194965A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Superhuman anti-sars-cov-2 antibodies and uses thereof
WO2021194886A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 3bgf
CN111349150B (zh) * 2020-03-24 2021-02-09 北京中科微盾生物科技有限责任公司 一种抑制新型冠状病毒的多肽及其用途
TWI896628B (zh) 2020-03-26 2025-09-11 美國凡德貝爾大學 針對嚴重急性呼吸症候群冠狀病毒２(SARS-CoV-2)之人單株抗體
US10787501B1 (en) 2020-04-02 2020-09-29 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
WO2021198999A1 (en) * 2020-04-03 2021-10-07 Axon Neuroscience Se Epitope-based vaccines for treatment of coronavirus associated diseases
WO2021205022A1 (en) * 2020-04-09 2021-10-14 Valneva Austria Gmbh Improved methods of producing a lipidated protein
US20210331150A1 (en) * 2020-04-24 2021-10-28 Kevin D. Fialko Sars-cov-2 susceptibility detection
US20230174628A1 (en) * 2020-04-28 2023-06-08 Peking University Anti-novel coronavirus monoclonal antibody and application thereof
WO2021221136A1 (ja) * 2020-05-01 2021-11-04 花王株式会社 抗ＳＡＲＳ－ＣｏＶ－２抗体
WO2021226123A1 (en) * 2020-05-06 2021-11-11 Academia Sinica Recombinant antibodies, kits comprising the same, and uses thereof
EP4146272A4 (en) * 2020-05-06 2024-10-23 International AIDS Vaccine Initiative, Inc. ANTI-COVID-19 ANTIBODIES AND THEIR USES
US20250195501A1 (en) * 2020-05-07 2025-06-19 Griffith University Cell entry-modulating agents and uses therefor
IL298035A (en) 2020-05-08 2023-01-01 Academia Sinica Chimeric influenza vaccines
US11789020B2 (en) * 2020-05-12 2023-10-17 Sapphire Biotech, Inc. Neutralizing antibody testing and treatment
JP2023527352A (ja) 2020-05-26 2023-06-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｓａｒｓ－ｃｏｖ－２－スパイク糖タンパク質抗体及び抗原結合断片
AU2021283349A1 (en) * 2020-06-03 2023-02-02 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing SARS-CoV-2 infections and COVID-19 with anti-SARS-CoV-2 spike glycoprotein antibodies
EP4176262B1 (en) 2020-07-02 2025-06-25 King Abdullah University Of Science And Technology Nanobody functionalized electrochemical transistors and methods of making and using thereof
JP2023534922A (ja) 2020-07-06 2023-08-15 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー ＳＡＲＳ－ＣｏＶ－２を標的とする抗原結合分子
JP2023534923A (ja) 2020-07-06 2023-08-15 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー ＳＡＲＳ－ＣｏＶ－２を標的にする抗原結合分子
EP4182687A4 (en) * 2020-07-20 2024-09-11 Bio-Rad Laboratories, Inc. IMMUNOASSAY FOR SARS-COV-2 NEUTRALISING ANTIBODIES AND MATERIALS THEREFOR
WO2022027037A1 (en) 2020-07-27 2022-02-03 Single Cell Technology, Inc. Anti-sars corona virus-2 spike protein antibodies
WO2022026592A2 (en) 2020-07-28 2022-02-03 Celltas Bio, Inc. Antibody molecules to coronavirus and uses thereof
TW202221024A (zh) * 2020-08-07 2022-06-01 美商索倫多醫療公司 結合sars-cov-2 s蛋白之中和抗體
CN111978378B (zh) * 2020-08-10 2022-02-01 武汉大学 SARS-CoV-2抗原多肽及其应用
US20220056111A1 (en) * 2020-08-11 2022-02-24 Yurogen Biosystems Llc MONOCLONAL ANTIBODY AGAINST SPIKE S1 PROTEIN OF SARS-CoV-2 AND USE THEREOFOF
JP7773154B2 (ja) * 2020-08-26 2025-11-19 国立大学法人 熊本大学 コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片
KR20230058434A (ko) 2020-08-26 2023-05-03 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 SARS-CoV-2를 표적으로 하는 항원 결합 분자
US20220074882A1 (en) * 2020-09-04 2022-03-10 Fraunhofer Usa, Inc. Electrochemical-based sensor for rapid and direct detection of sars-cov-2
WO2022054068A1 (en) * 2020-09-14 2022-03-17 Ramot At Tel-Aviv University Ltd. Antibodies for the prevention, treatment and detection of coronavirus infection
WO2022053054A1 (en) * 2020-09-14 2022-03-17 Vazyme Biotech Co., Ltd. Neutralizing antibodies against sars-cov-2
WO2022060916A1 (en) 2020-09-15 2022-03-24 Regenxbio Inc. Vectorized antibodies for anti-viral therapy
TWI796597B (zh) * 2020-09-21 2023-03-21 長庚大學 使用紫蘇之經水萃取的產物來對抗冠狀病毒感染的方法
CN112175073B (zh) * 2020-09-30 2022-08-02 上海市公共卫生临床中心 冠状病毒的中和抗体或其抗原结合片段
WO2022068895A1 (zh) * 2020-09-30 2022-04-07 南京金斯瑞生物科技有限公司 抗SARS-CoV-2刺突蛋白膜外区的单克隆抗体及其应用
CN115710311B (zh) * 2020-09-30 2025-09-02 超非凡(上海)医疗科技有限公司 冠状病毒的抗体或其抗原结合片段
US20230390414A1 (en) * 2020-09-30 2023-12-07 The Research Foundation For The State University Of New York Particle based formulation of sars-cov-2 receptor binding domain
CN112125973B (zh) * 2020-09-30 2022-02-01 上海市公共卫生临床中心 冠状病毒的特异性抗体或其抗原结合片段
WO2022068844A1 (en) * 2020-09-30 2022-04-07 Vazyme Biotech Co., Ltd. Neutralizing antibody against sars-cov-2
AU2021355518A1 (en) * 2020-10-02 2023-06-08 Eli Lilly And Company Methods for reducing host cell protein content in protein purification processes
WO2022075921A1 (en) * 2020-10-08 2022-04-14 Hummingbird Bioscience Holdings Limited Sars-cov-2 spike protein antigen-binding molecules
KR20230083316A (ko) * 2020-10-09 2023-06-09 더 호스피탈 포 식 칠드런 Sars-cov-2를 표적화하는 폴리펩티드, 및 관련 조성물 및 방법
WO2022079606A1 (en) * 2020-10-12 2022-04-21 Icosagen Cell Factory Oü Sars cov-2 neutralizing antibodies
CN112251414A (zh) * 2020-10-12 2021-01-22 中国科学院苏州纳米技术与纳米仿生研究所 一种杂交瘤细胞株、其制备方法和应用
WO2022081436A1 (en) * 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
CN112194711A (zh) * 2020-10-15 2021-01-08 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） 一种新型冠状病毒s蛋白的b细胞线性抗原表位、抗体、鉴定方法及应用
AU2021362007A1 (en) 2020-10-16 2023-06-22 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
WO2022084817A1 (en) * 2020-10-19 2022-04-28 Lay Sciences Inc. Protein drugs for prevention and treatment of covid-19
WO2022087127A1 (en) * 2020-10-20 2022-04-28 Duke University Replication incompetent influenza vaccine platform for foreign protein delivery
GB202016650D0 (en) * 2020-10-20 2020-12-02 Primer Design Ltd Kit and method
US20230398204A1 (en) * 2020-10-21 2023-12-14 La Jolla Institute For Immunology Coronavirus Spike Glycoprotein With Improved Expression and Stability
US20240025971A1 (en) * 2020-10-23 2024-01-25 Atreca, Inc. Antibodies to coronavirus sars-cov-2
CN112409488B (zh) * 2020-10-23 2022-07-01 中国科学院上海药物研究所 针对多种冠状病毒的单克隆抗体及应用
KR20220054080A (ko) * 2020-10-23 2022-05-02 주식회사 와이바이오로직스 SARS-CoV-2 스파이크 단백질에 특이적으로 결합하는 항체 및 이의 용도
WO2022093745A1 (en) * 2020-10-26 2022-05-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting sars coronavirus spike protein and uses thereof
US20240018191A1 (en) * 2020-10-27 2024-01-18 The University Of North Carolina At Chapel Hill Chimeric coronavirus s protein compositions and methods of use
IL302460A (en) * 2020-10-30 2023-06-01 Adaptive Biotechnologies Corp Antibodies against SARS-COV-2 antigen and related compositions and methods
US11872279B2 (en) 2020-10-30 2024-01-16 Massachusetts Institute Of Technology SARS-CoV-2 antigens and uses thereof
US11453705B2 (en) 2020-10-30 2022-09-27 Achelois Biopharma, Inc. Multivalent particles compositions and methods of use
US11739137B2 (en) * 2020-10-30 2023-08-29 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Single domain antibodies to SARS-CoV-2 nucleocapsid protein
CN112358533B (zh) * 2020-10-30 2023-07-14 上海泽润生物科技有限公司 重组刺突蛋白及其制备方法和用途
EP4237444A4 (en) * 2020-11-02 2024-11-27 The University of Chicago POLYPEPTIDES FOR THE DETECTION AND TREATMENT OF SARS-COV-2
CN112098660B (zh) * 2020-11-03 2021-02-09 北京百普赛斯生物科技股份有限公司 新型冠状病毒中和性抗体检测试剂盒
MX2023005154A (es) * 2020-11-03 2023-08-01 Wistar Inst Nanopartículas codificadas de adn y método de uso de las mismas como una vacuna contra la enfermedad corona virus (covid-19).
EP4240758A1 (en) * 2020-11-04 2023-09-13 The Rockefeller University Neutralizing anti-sars-cov-2 antibodies
JP7599186B2 (ja) * 2020-11-06 2024-12-13 グリーン・クロス・コーポレイション コロナウイルススパイクタンパク質に特異的な抗体及びその用途
CA3196069A1 (en) * 2020-11-06 2022-05-12 Cho Pharma, Inc. Immune composition comprising antigen and glycoengineered antibody thereof
WO2022095045A1 (zh) * 2020-11-09 2022-05-12 上海济煜医药科技有限公司 SARS-CoV-2抗体及其应用
WO2022101839A1 (en) * 2020-11-12 2022-05-19 Cadila Healthcare Limited Anti-sars-cov-2 monoclonal antibodies and cocktail thereof
AU2021323389B1 (en) * 2020-11-12 2022-03-24 Ahs Hospital Corp. SARS-CoV-2 immunodominant peptide constructs and uses thereof
WO2022102744A1 (ja) * 2020-11-13 2022-05-19 株式会社ハカレル ＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に対する抗体
CN112625136B (zh) * 2020-11-18 2022-02-11 三优生物医药(上海)有限公司 针对冠状病毒具有中和活性的双特异性抗体及其用途
WO2022109441A1 (en) * 2020-11-23 2022-05-27 Genentech, Inc. Methods for modulating host cell surface interactions with sars-cov-2
CN112409479B (zh) * 2020-11-23 2022-04-26 中国疾病预防控制中心病毒病预防控制所 人源抗新冠病毒中和性抗体nCoV-121及其应用
WO2022115538A1 (en) * 2020-11-24 2022-06-02 Bio-Techne Corporation Anti-severe acute respiratory syndrome coronavirus antibodies
CN112439058A (zh) * 2020-11-25 2021-03-05 深圳市第二人民医院(深圳市转化医学研究院) 基于外泌体为载体的重组新型冠状病毒纳米疫苗方法
CN112442120A (zh) * 2020-11-25 2021-03-05 苏州大学 抗严重急性呼吸系统综合征ii型冠状病毒sars-cov-2的中和抗体
JP2023553809A (ja) * 2020-11-25 2023-12-26 デシフェラ・ファーマシューティカルズ，エルエルシー ウイルス感染の治療に使用するためのｖｓｐ３４阻害剤としてのピリジルピリドン誘導体
US20220184093A1 (en) * 2020-11-25 2022-06-16 Deciphera Pharmaceuticals, Llc Anti-viral activity of vps34 inhibitors
WO2022115562A1 (en) * 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
WO2022112392A1 (en) 2020-11-26 2022-06-02 Memo Therapeutics Ag Anti-sars-cov-2 antibody molecules
WO2022120130A1 (en) 2020-12-03 2022-06-09 Regeneron Pharmaceuticals, Inc. Methods of identifying subjects having an increased risk of developing a coronavirus infection and treatment thereof
EP4255487A4 (en) * 2020-12-04 2025-05-28 The University of Chicago Polypeptides for detection and treatment of coronavirus infection
WO2022126119A2 (en) * 2020-12-09 2022-06-16 The University Of Chicago Methods and systems for detection and analysis of angiotensin binding antibodies
WO2022122788A1 (en) * 2020-12-09 2022-06-16 Institute For Research In Biomedicine Multispecific antibodies against severe acute respiratory syndrome coronavirus 2
WO2022125789A1 (en) * 2020-12-09 2022-06-16 Yale University Compositions and methods for treating, ameliorating, and/or preventing viral infections
US11693011B2 (en) 2020-12-14 2023-07-04 Inbios International, Inc. Neutralizing antibody immunoassays
WO2022132887A1 (en) * 2020-12-15 2022-06-23 Board Of Regents, The University Of Texas System Human monoclonal antibodies targeting the sars-cov-2 spike protein
WO2022132904A1 (en) * 2020-12-17 2022-06-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies targeting sars-cov-2
WO2022139680A1 (en) * 2020-12-21 2022-06-30 Chugai Seiyaku Kabushiki Kaisha Sars-cov-2 binding molecules and uses thereof
KR102779353B1 (ko) * 2020-12-22 2025-03-12 한국과학기술원 컴퓨터를 이용해 디자인된 SARS-CoV-2 수용체결합 도메인 특이적 항체 또는 그의 항원 결합 단편
WO2022133545A1 (en) * 2020-12-23 2022-06-30 Garvan Institute Of Medical Research Sars-cov-2 antibodies
CN112794884B (zh) * 2020-12-28 2022-02-18 中国科学院微生物研究所 新型冠状病毒蛋白、制备方法及中和抗体检测试剂盒
CN112326973B (zh) * 2020-12-31 2021-03-23 北京金沃夫生物工程科技有限公司 一种用于检测新型冠状病毒抗体的试剂盒及其应用
WO2022147290A1 (en) * 2020-12-31 2022-07-07 The Broad Institute, Inc. Cross-neutralizing sars-cov2 antibodies
TW202241497A (zh) * 2021-01-05 2022-11-01 美商伊米若梅有限公司 針對SARS-CoV-2棘蛋白之抗體雞尾酒療法
WO2022150660A1 (en) * 2021-01-08 2022-07-14 10X Genomics, Inc. Antigen-binding polypeptides specific for coronaviruses and uses thereof
WO2022158497A1 (ja) * 2021-01-22 2022-07-28 株式会社mAbProtein ＳＡＲＳ－ＣｏＶ－２スパイクタンパク質に対する抗体
US20240301037A1 (en) * 2021-01-22 2024-09-12 La Jolla Institute For Immunology Chimeric anti-coronavirus spike protein antibodies
WO2022162587A1 (en) * 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
CN113264998B (zh) * 2021-01-28 2023-02-28 四川大学华西医院 抗新冠病毒SARS-CoV-2表面S1蛋白的单链抗体及其应用
AR124707A1 (es) * 2021-01-28 2023-04-26 Talem Therapeutics Llc Anticuerpos antiglicoproteína de espiga y su uso terapéutico
JP7598538B2 (ja) * 2021-01-29 2024-12-12 東亞合成株式会社 ＳＡＲＳ－ＣｏＶ－２由来のアミノ酸配列およびその利用
CN115141271B (zh) * 2021-01-31 2024-06-11 中南大学湘雅医院 新型冠状病毒单克隆抗体xy7及其应用
RU2771288C1 (ru) * 2021-02-02 2022-04-29 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Штамм гибридных клеток животных Mus musculus 2E1B5 - продуцент моноклонального антитела к рецептор-связывающему домену белка S вируса SARS-CoV-2
JP2024509055A (ja) * 2021-02-04 2024-02-29 アールキュー・バイオテクノロジー・リミテッド 抗体
US20240117011A1 (en) * 2021-02-09 2024-04-11 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Antibodies targeting the spike protein of coronaviruses
US20240254167A1 (en) 2021-02-15 2024-08-01 Livingmed Biotech S.R.L. Genetically modified clostridium strains expressing recombinant antigens and uses thereof
EP4297786A4 (en) * 2021-02-23 2025-01-22 Pandion Operations, Inc. PD-1 ANTIBODIES, POLYPEPTIDES AND USES THEREOF
WO2022182662A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Compositions and methods for mapping antigen-binding molecule affinity to antigen regions of interest
CN113009153B (zh) * 2021-02-25 2023-12-15 山东莱博生物科技有限公司 一种基于磁微粒化学发光的新冠病毒中和抗体检测试剂盒及其应用
US12024551B1 (en) * 2021-03-04 2024-07-02 National Technology & Engineering Solutions Of Sandia, Llc Coronavirus neutralizing humanized antibodies and uses thereof
CA3177045A1 (en) * 2021-03-15 2022-09-22 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating coronavirus infection
CN112679605B (zh) * 2021-03-15 2021-07-09 安源医药科技（上海）有限公司 针对新型冠状病毒核衣壳蛋白的抗体或其抗原结合片段及其应用
EP4063384A1 (en) * 2021-03-23 2022-09-28 Ceinge Biotecnologie Avanzate SCarl Human neutralizing antigen specific proteins for spike-rbd of sars-cov-2
CN113092776B (zh) * 2021-03-24 2024-12-10 苏州携创生物技术有限公司 一种SARS-CoV-2中和抗体检测试剂盒
US20240301038A1 (en) * 2021-03-26 2024-09-12 Atreca, Inc. Antibodies to sars-cov-2
CN115141270A (zh) * 2021-03-29 2022-10-04 深圳市康麦生物技术有限公司 特异性结合新型冠状病毒的抗体
WO2022210830A1 (ja) * 2021-03-30 2022-10-06 国立大学法人 富山大学 抗ＳＡＲＳ－ＣｏＶ－２抗体
WO2022211558A1 (ko) * 2021-04-01 2022-10-06 (주)셀트리온 사스-코로나바이러스-2 스파이크 단백질의 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자
CN117042805A (zh) * 2021-04-05 2023-11-10 株式会社Lg化学 对抗冠状病毒的疫苗组合物
WO2022216028A1 (ko) * 2021-04-08 2022-10-13 한국생명공학연구원 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방용 중화능 개량 백신 조성물
EP4164687A4 (en) 2021-04-12 2024-08-14 Academia Sinica IMPROVED CORONAVIRUS VACCINE
WO2022220603A1 (ko) * 2021-04-16 2022-10-20 고려대학교 산학협력단 코로나-19 바이러스 표적 인간 항체
AR125373A1 (es) * 2021-04-19 2023-07-12 Bharat Serums & Vaccines Ltd ANTICUERPOS POLICLONALES CONTRA SARS-CoV-2 Y SUS APLICACIONES
CA3216279A1 (en) * 2021-04-20 2022-10-27 D4 Labs, Llc Adjuvanted vaccine composition and methods
WO2022226079A1 (en) * 2021-04-20 2022-10-27 Inbios International, Inc. Neutralizing antibodies against sars-cov-2
WO2023033363A1 (ko) * 2021-09-06 2023-03-09 국민대학교산학협력단 Sars-cov-2에 특이적으로 결합하는 이중특이적 항체
KR102426782B1 (ko) * 2021-04-27 2022-07-28 국민대학교산학협력단 SARS-CoV-2 RBD 항원 특이적 항체를 포함하는 진단용 조성물 또는 키트
WO2022231320A1 (ko) * 2021-04-27 2022-11-03 국민대학교산학협력단 Sars-cov-2 s 단백질에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편, 및 이들의 용도
MX2023012879A (es) * 2021-04-28 2023-11-24 Univ Columbia Anticuerpos para el tratamiento y prevención de covid-19 y variantes emergentes.
WO2022235678A1 (en) * 2021-05-03 2022-11-10 Ohio State Innovation Foundation Human anti-coronavirus peptide vaccines and methods of their use
WO2022235960A1 (en) * 2021-05-06 2022-11-10 Sorrento Therapeutics, Inc. Neutralizing antibodies that bind variant sars-cov-2 spike proteins
EP4337689A1 (en) * 2021-05-12 2024-03-20 Applied Biomedical Science Institute Binding polypeptides against sars cov-2 and uses thereof
CN112981011B (zh) * 2021-05-12 2021-08-17 广东凯普生物科技股份有限公司 一种检测SARS-CoV-2的引物组合物及其应用
EP4089112A1 (en) * 2021-05-14 2022-11-16 Ustav organicke chemie a biochemie AV CR, v.v.i. Antibody binding to rbd of spike protein of sars-cov-2 and a method for quantifying protective antibodies against sars-cov-2
GB202107057D0 (en) 2021-05-18 2021-06-30 Univ York Glycosylation method
JP2024521098A (ja) * 2021-05-20 2024-05-28 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ ＳＡＲＳ－ＣｏＶ－２ポリペプチド
WO2022251403A1 (en) * 2021-05-28 2022-12-01 Icahn School Of Medicine At Mount Sinai Sars-cov-2 antibodies and uses thereof
CN113354733B (zh) * 2021-06-04 2022-02-18 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2流行突变株的单克隆抗体20D8
JP2024522165A (ja) * 2021-06-08 2024-06-11 イーライ リリー アンド カンパニー ２０１９新型コロナウイルス抗体含有医薬製剤
CN113416245A (zh) * 2021-06-15 2021-09-21 北京华大蛋白质研发中心有限公司 一种可结合SARS-CoV-2病毒RBD蛋白的中和抗体及其应用
WO2022263638A1 (en) * 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
WO2022271884A2 (en) * 2021-06-22 2022-12-29 Twist Bioscience Corporation Methods and compositions relating to covid antibody epitopes
WO2022271258A1 (en) * 2021-06-25 2022-12-29 La Jolla Institute For Immunology Chimeric anti-sars-cov2 nucleoprotein antibodies
CN113584223B (zh) * 2021-06-28 2024-01-12 中国人民解放军疾病预防控制中心 基于CRISPR-Cas12a的SARS-CoV-2中D614G突变鉴定方法
CN115594758A (zh) * 2021-06-28 2023-01-13 南京晶准生物科技有限公司（Cn） 抗新型冠状病毒SARS-CoV-2的纳米抗体及其制备方法和用途
WO2023275538A1 (en) * 2021-06-28 2023-01-05 Diosynvax Ltd Beta-coronavirus vaccines
EP4367134A1 (en) 2021-07-05 2024-05-15 Regeneron Pharmaceuticals, Inc. Utilization of antibodies to shape antibody responses to an antigen
BR112024000744A2 (pt) 2021-07-14 2024-04-30 Regeneron Pharma Anticorpos de glicoprotéina spike anti-sars-cov-2 e fragmentos de ligação a antígeno
WO2023285620A2 (en) * 2021-07-14 2023-01-19 Alchemab Therapeutics Ltd. Compositions and methods for targeting viral proteins
GB202110391D0 (en) 2021-07-19 2021-09-01 Tissue Click Ltd A detection kit and methods of detection of infectious agents
JPWO2023002944A1 (enExample) * 2021-07-19 2023-01-26
CN113621651A (zh) * 2021-07-19 2021-11-09 南昌五元生物科技有限公司 一种基于s-tet蛋白表达系统的细胞合胞体病变模型及其制备方法
AU2022313322A1 (en) * 2021-07-23 2024-02-01 The Trustees Of Columbia University In The City Of New York Characterization of potent and broadly neutralizing monoclonal antibodies against sars-cov-2, its variants, and related coronaviruses and methods of use
US11724077B2 (en) * 2021-07-28 2023-08-15 Subhash Dhawan Therapeutic swabs for treating upper respiratory infections
WO2023008463A1 (ja) * 2021-07-28 2023-02-02 株式会社イーベック ＳＡＲＳ－ＣｏＶ－２野生株および変異株に対する中和ヒト抗体およびその抗原結合性断片
WO2023004477A1 (en) * 2021-07-30 2023-02-02 The University Of Melbourne Neutralising antibodies and uses thereof
CN113512113B (zh) * 2021-08-03 2024-07-05 浙江大学医学院附属第一医院 人源化广谱高中和活性抗新型冠状病毒单克隆抗体及应用
US20250297277A1 (en) * 2021-08-04 2025-09-25 The J. David Gladstone Intitutes, a testamentary trust established under the Will of J. David SARS-CoV-2 Virus-Like Particles
WO2023023183A2 (en) * 2021-08-17 2023-02-23 Twist Bioscience Corporation Sars-cov-2 antibodies and related compositions and methods of use
WO2023026207A1 (en) * 2021-08-25 2023-03-02 Translational Health Science And Technology Institute Potently neutralizing novel human monoclonal antibodies against sars-cov-2 (covid-19)
US20240270828A1 (en) * 2021-09-03 2024-08-15 The Uab Research Foundation Human neutralizing antibodies against sars-cov-2 spike s2 domain and uses thereof
WO2023048656A2 (en) * 2021-09-24 2023-03-30 Chulalongkorn University Human monoclonal antibodies against the receptor-binding domain of sars-cov-2 spike protein
TW202334429A (zh) 2021-10-01 2023-09-01 中央研究院 Sars-cov-2棘蛋白特異性抗體及其用途
WO2023064717A2 (en) * 2021-10-08 2023-04-20 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof
WO2023064435A2 (en) * 2021-10-15 2023-04-20 The Children's Medical Center Corporation Compositions and methods relating to sars-cov-2 neutralizing antibodies
WO2023070029A1 (en) * 2021-10-20 2023-04-27 Arizona Board Of Regents On Behalf Of Arizona State University DNA ORIGAMI SUBUNIT VACCINE FOR PREVENTION OF SARS-CoV-2 VARIANT INFECTION
WO2023081434A2 (en) * 2021-11-07 2023-05-11 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies
EP4430070A1 (en) * 2021-11-12 2024-09-18 RQ Biotechnology Limited Compositions
US20250026814A1 (en) * 2021-11-16 2025-01-23 The University Of Chicago Polypeptides for detection and treatment of coronavirus infection
EP4190810A1 (en) * 2021-12-01 2023-06-07 Universität zu Köln Neutralizing antibodies against sars-related coronavirus
IL313010A (en) * 2021-12-01 2024-07-01 Universit?T Zu K?Ln Antibodies neutralize SARS-causing corona viruses
CN113862286B (zh) * 2021-12-03 2022-03-04 艾棣维欣(苏州)生物制药有限公司 编码sars-cov-2病毒c.37突变株抗原的dna分子、dna疫苗及应用
WO2023104904A2 (en) * 2021-12-08 2023-06-15 Genclis The sars-cov-2 and variants use two independent cell receptors to replicate
CN116802496A (zh) * 2021-12-14 2023-09-22 杭州安旭生物科技股份有限公司 一种可结合SARS-CoV-2病毒的中和抗体及其应用
WO2023113094A1 (ko) * 2021-12-16 2023-06-22 주식회사 씨티씨백 면역원성이 증가된 코로나바이러스감염증-19 백신 조성물
WO2023122535A2 (en) * 2021-12-20 2023-06-29 DNARx Nucleic acid expression using subcutaneous administration
WO2023129928A2 (en) * 2021-12-27 2023-07-06 Academia Sinica Antibody specific to spike protein of sars-cov-2 and uses thereof
WO2023137443A1 (en) 2022-01-14 2023-07-20 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof
TWI868567B (zh) * 2022-01-26 2025-01-01 中央研究院 冠狀病毒之特異性抗體及其用途
WO2023145859A1 (ja) 2022-01-28 2023-08-03 株式会社イーベック 変異株交差性を有する抗ＳＡＲＳ－ＣｏＶ－２ヒト中和抗体およびその抗原結合性断片
WO2023152188A1 (en) * 2022-02-11 2023-08-17 Attana Ab Analytical method
WO2023156187A1 (en) * 2022-02-16 2023-08-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts High affinity antibodies against the sars-cov-2 receptor binding domain
JP2025507595A (ja) * 2022-02-18 2025-03-21 アールキューバイオ・コビッド・リミテッド コロナウイルスＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に結合することができる抗体
TW202342510A (zh) * 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
CN114231497B (zh) * 2022-02-24 2022-05-20 广州伯尼兹生物科技有限公司 一株表达SARS-CoV-2 S1蛋白单克隆抗体杂交瘤细胞系及中和活性抗体
WO2023178182A1 (en) 2022-03-16 2023-09-21 10X Genomics, Inc. Compositions and methods for detection and treatment of coronavirus infection
WO2023190852A1 (ja) * 2022-03-31 2023-10-05 公立大学法人福島県立医科大学 新型コロナウイルス（ＳＡＲＳ－ＣｏＶ－２）に結合する抗体
JP2025081789A (ja) * 2022-03-31 2025-05-28 公立大学法人福島県立医科大学 新型コロナウイルス（ＳＡＲＳ－ＣｏＶ－２）に結合する抗体
WO2023201304A2 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions for preventing or treating coronavirus infections
EP4508077A1 (en) 2022-04-14 2025-02-19 Invisishield Technologies Ltd. Compositions for preventing or treating influenza infections
AU2023265164A1 (en) 2022-05-06 2024-11-21 Generate Biomedicines, Inc. Antigen binding molecules targeting sars-cov-2
CN115287265B (zh) * 2022-07-12 2023-05-23 四川大学华西医院 多能活性制剂诱发恒河猴抵抗新冠突变体的免疫防治模型
EP4335870A1 (en) * 2022-09-06 2024-03-13 NantCell, Inc. Peptide therapeutics against sars-cov-2 spike protein
EP4349860A1 (en) 2022-10-06 2024-04-10 Fundació Institut Hospital Del Mar D'Investigacions Mèdiques (IMIM) Anti-sars-cov-2 antibodies
TW202426045A (zh) * 2022-10-07 2024-07-01 高端疫苗生物製劑股份有限公司 抗新型冠狀病毒(SARS-CoV-2) Omicron變異株之免疫組合物
KR102879761B1 (ko) * 2022-12-13 2025-11-07 대한민국 코로나바이러스감염증-19 예방 또는 치료용 백신 조성물
IL322940A (en) 2023-02-28 2025-10-01 Regeneron Pharma Multivalent anti-spike protein binding molecules and their uses
IL322941A (en) 2023-02-28 2025-10-01 Regeneron Pharma Multivalent anti-spike protein binding molecules and their uses
CN120981246A (zh) * 2023-04-07 2025-11-18 西奈山伊坎医学院 针对钙粘蛋白11的单克隆抗体及使用方法
IL319558A (en) 2023-04-08 2025-05-01 Rock Biomedical Inc Methods and compositions for targeted delivery using polymersomes
US20250011449A1 (en) 2023-06-11 2025-01-09 Regeneron Pharmaceuticals, Inc. Circularized antibody molecules
WO2024258866A1 (en) * 2023-06-12 2024-12-19 Interius Biotherapeutics, Inc. Compositions and methods for the treatment of immunological disorders
CN117379399A (zh) * 2023-06-27 2024-01-12 江生(深圳)生物技术研发中心有限公司 马源免疫球蛋白吸入液体制剂及其制备和使用方法
WO2025064752A1 (en) * 2023-09-20 2025-03-27 La Jolla Institute For Immunology Human anti-sars-cov-2 spike (s) antibodies
JP2025168320A (ja) * 2024-04-26 2025-11-07 イーライ リリー アンド カンパニー タンパク質チロシンキナーゼ７抗体及び抗体－薬物コンジュゲート

Family Cites Families (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5908635A (en) 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7892563B2 (en) 2003-05-20 2011-02-22 Wyeth Holdings Corporation Methods for treatment of severe acute respiratory syndrome (SARS)
US7750123B2 (en) * 2003-11-25 2010-07-06 Dana Farber Cancer Institute, Inc. Antibodies against SARS-CoV and methods of use thereof
US7629443B2 (en) * 2004-06-02 2009-12-08 New York Blood Center, Inc. Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
CA2652976C (en) 2006-06-02 2015-08-11 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
EP2057191A1 (en) 2006-08-18 2009-05-13 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
GB0624500D0 (en) 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
EP2242768A4 (en) 2008-01-17 2012-03-14 Humabs Llc CROSS-NEUTRALIZATION OF HUMAN MONOCLONAL ANTIBODIES AGAINST SARS-COV AND METHODS FOR THEIR APPLICATION
US9212226B2 (en) 2008-05-16 2015-12-15 Ablynx N.V. Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
WO2014022540A1 (en) 2012-08-02 2014-02-06 Regeneron Pharmaceuticals, Inc. Multivalent antigen-binding proteins
US9884895B2 (en) * 2014-03-20 2018-02-06 The University Of North Carolina At Chapel Hill Methods and compositions for chimeric coronavirus spike proteins
JO3701B1 (ar) * 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
KR102369014B1 (ko) 2016-08-16 2022-03-02 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
IL276164B2 (en) 2018-01-26 2024-11-01 Regeneron Pharma Anti-tmprss2 antibodies and antigen-binding fragments
WO2021001388A1 (en) 2019-07-03 2021-01-07 Merck Patent Gmbh Glycoform purification
WO2021026074A1 (en) 2019-08-02 2021-02-11 University Of Virginia Patent Foundation Bispecific antibody targeting of t regulatory cells for treatment of inflammatory conditions
CN114599389A (zh) 2019-08-22 2022-06-07 奇达拉治疗公司 变体fc结构域及其用途
EP3795163A1 (en) 2019-09-23 2021-03-24 The Ceutics Company GesmbH A topical plant extract formulation comprising urtica dioica and vitamin a
US12048741B2 (en) 2019-09-27 2024-07-30 George Mason University Recombinant host cell with heterologous nucleic acids encoding SHREK proteins
CN111748571B (zh) 2019-10-11 2022-05-03 浙江禾霖生物科技有限公司 一种将枯草芽孢杆菌工程化为生产纳米抗体的多功能稳定平台的方法
CN114787928A (zh) 2019-11-12 2022-07-22 雷杰纳荣制药公司 用于鉴定、分类和/或排序遗传序列的方法和系统
WO2021148884A1 (en) 2020-01-24 2021-07-29 Tychan Pte. Ltd. Anti-wuhan coronavirus antibodies
CA3165957A1 (en) * 2020-01-24 2021-07-29 Thomas K. EQUELS Methods, compositions, and vaccines for treating a virus infection
CN113201068A (zh) 2020-02-03 2021-08-03 深圳市雅臣智能生物工程有限公司 基因重组抗2019-nCoV和其它冠状病毒IgY及其小分子抗体以及应用
AU2021220847A1 (en) 2020-02-11 2022-09-01 Vanderbilt University Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2)
CN113248579B (zh) 2020-02-12 2022-10-18 重庆医科大学 新型冠状病毒（2019-ncov）抗原表位、抗体及其应用
CN111303254A (zh) 2020-02-20 2020-06-19 北京新创生物工程有限公司 新型冠状病毒（SARS-CoV-2）抗原检测试剂盒
DE202020105116U1 (de) 2020-02-20 2020-10-06 Charité - Universitätsmedizin Berlin Reagenzien und Verwendungen zur Diagnose einer SARS-CoV-2-Infektion
WO2021168483A2 (en) * 2020-02-21 2021-08-26 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors
US20210260201A1 (en) 2020-02-21 2021-08-26 Physis Biotechnologies, Llc Extracellular vesicles for the treatment and prevention of infections and other diseases
CN111333704B (zh) 2020-02-24 2021-01-12 军事科学院军事医学研究院微生物流行病研究所 新型冠状病毒covid-19疫苗、制备方法及其应用
CN113292649B (zh) 2020-02-24 2022-08-12 中国科学院微生物研究所 新型冠状病毒的人源单克隆抗体及其应用
CN113292650B (zh) 2020-02-24 2022-08-12 中国科学院微生物研究所 新型冠状病毒的人源单克隆抗体及其应用
KR20220158723A (ko) 2020-02-25 2022-12-01 리간달 인코포레이티드 생체모방 바이러스 펩티드의 확인 및 그의 용도
CN113307865B (zh) 2020-02-26 2022-12-13 复旦大学 新型冠状病毒的全人源单域抗体及应用
TWI859420B (zh) 2020-02-26 2024-10-21 美商維爾生物科技股份有限公司 抗sars-cov-2抗體及使用其之方法
EP3885361A1 (en) 2020-02-27 2021-09-29 Macrofarm Srl Monoclonal-type synthetic antibodies obtained by molecular imprinting and their use for the treatment and preventive medicine of covid-19
CN113354731A (zh) 2020-03-02 2021-09-07 中国科学院微生物研究所 冠状病毒的人源单克隆抗体及其应用
CN111333722A (zh) 2020-03-03 2020-06-26 江苏省疾病预防控制中心(江苏省公共卫生研究院) SARS-CoV-2抑制剂及其应用
WO2021178637A1 (en) 2020-03-05 2021-09-10 Iowa State University Research Foundation, Inc. IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2
US20210292393A1 (en) 2020-03-09 2021-09-23 Abcellera Biologics Inc. Anti-Coronavirus Antibodies and Methods of Use
CN111285933A (zh) 2020-03-09 2020-06-16 四川省人民医院 一种新型冠状病毒抗原胶体金诊断试剂盒
US20210277093A1 (en) 2020-03-09 2021-09-09 Adma Biologics, Inc. Immunotherapeutic compositions and methods of production for coronavirus
CN111420048B (zh) 2020-03-11 2023-09-19 中国人民解放军第四军医大学 抗basigin人源化抗体用于制备治疗新型冠状病毒肺炎药物的应用
WO2021183790A1 (en) 2020-03-12 2021-09-16 Rigel Pharmaceuticals, Inc. Method for treatment of covid-19-associated conditions
US10822379B1 (en) 2020-03-12 2020-11-03 University of Pittsburgh—of the Commonwealth System of Higher Education Molecules that bind to SARS-CoV-2
GB202003632D0 (en) 2020-03-12 2020-04-29 Harbour Antibodies Bv SARS-Cov-2 (SARS2, COVID-19) antibodies
CN112646005B (zh) 2020-03-13 2023-06-20 深圳碳云智肽药物科技有限公司 多肽、多肽疫苗及应用
CN111592594B (zh) 2020-03-13 2022-05-10 北京大学 一种抗新型冠状病毒的单克隆抗体及其应用
CN111303279B (zh) 2020-03-17 2022-02-15 北京凯因科技股份有限公司 一种针对新型冠状病毒的单域抗体及其应用
CN111088283B (zh) * 2020-03-20 2020-06-23 苏州奥特铭医药科技有限公司 mVSV病毒载体及其病毒载体疫苗、一种基于mVSV介导的新冠肺炎疫苗
KR102205028B1 (ko) 2020-03-22 2021-01-20 (주)셀트리온 사스-코로나바이러스-2에 중화 활성을 갖는 결합 분자
WO2021190980A1 (en) * 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
CN111303280B (zh) 2020-03-22 2022-01-07 中国人民解放军军事科学院军事医学研究院 高中和活性抗SARS-CoV-2全人源单克隆抗体及应用
US11028150B1 (en) 2020-03-23 2021-06-08 Centivax, Inc. Anti-SARS-CoV-2 antibodies derived from 2DD8
US11021531B1 (en) 2020-03-23 2021-06-01 Centivax, Inc. Anti-SARS-Cov-2 antibodies derived from 2GHW
US11021532B1 (en) 2020-03-23 2021-06-01 Centivax, Inc. Superhuman anti-SARS-CoV-2 antibodies and uses thereof
US11028167B1 (en) 2020-03-23 2021-06-08 Centivax, Inc. Anti-SARS-Cov-2 antibodies derived from 3bgf
CN111690058B (zh) 2020-03-30 2021-02-05 三优生物医药(上海)有限公司 针对冠状病毒的具有中和活性的抗体及其用途
CN111848750B (zh) 2020-03-31 2023-09-12 浙江聚康生物工程有限公司 一种快速富集和检测2019-nCoV的方法及试剂盒
CN111423508A (zh) 2020-03-31 2020-07-17 江苏省疾病预防控制中心(江苏省公共卫生研究院) 一种分离的抗病毒感染的SARS-CoV-2蛋白结合分子
US10787501B1 (en) 2020-04-02 2020-09-29 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
CA3174212A1 (en) * 2020-04-03 2021-10-07 Blis Technologies Limited Antiviral treatment comprising blis containing probiotic products
WO2021203053A1 (en) 2020-04-03 2021-10-07 Vir Biotechnology, Inc. Immunotherapy targeting a conserved region in sars coronaviruses
CN111499765B (zh) 2020-04-08 2022-04-08 四川携光生物技术有限公司 一种冠状病毒融合蛋白及其制备方法与应用
CN111440229B (zh) 2020-04-13 2021-08-03 中国人民解放军军事科学院军事医学研究院 新型冠状病毒t细胞表位及其应用
US20210388065A1 (en) 2020-04-15 2021-12-16 Active Motif Shanghai Limited Antibodies to sars-coronavirus (covid-19) s1 spike protein
CN111647053A (zh) 2020-04-16 2020-09-11 军事科学院军事医学研究院生命组学研究所 多肽及其在新型冠状病毒检测、抗体或疫苗筛选中的应用
CN111647076B (zh) 2020-04-27 2021-02-26 南京医科大学 抗新型冠状病毒SARS-Cov-2的中和性单域抗体及其应用
CN111592595B (zh) 2020-04-27 2021-02-19 南京医科大学 抗新型冠状病毒SARS-Cov-2的中和性抗体及其应用
US11634477B2 (en) 2020-04-28 2023-04-25 The Rockefeller University Neutralizing anti-SARS-CoV-2 antibodies and methods of use thereof
CN111471105A (zh) 2020-05-05 2020-07-31 广西医科大学 新冠病毒银治疗性中和抗体制备及应用
JP2023525039A (ja) 2020-05-08 2023-06-14 ヴィア・バイオテクノロジー・インコーポレイテッド Ｓａｒｓ－ｃｏｖ－２に対する抗体
CN111518773B (zh) 2020-05-09 2023-01-03 山东兴瑞生物科技有限公司 一种抗新型冠状病毒s蛋白的car-t细胞、制备方法及其应用
CN111620945B (zh) 2020-05-09 2021-01-15 江苏省疾病预防控制中心(江苏省公共卫生研究院) 一种抗新型冠状病毒的单克隆抗体或其衍生体
CN111620946B (zh) 2020-05-09 2020-12-22 江苏省疾病预防控制中心(江苏省公共卫生研究院) 分离的新型冠状病毒单克隆抗体或其抗原结合部分
CN111662379B (zh) 2020-05-09 2021-03-02 江苏省疾病预防控制中心(江苏省公共卫生研究院) 抗新型冠状病毒的抗体、制备方法和应用
CN112010966B (zh) 2020-05-15 2021-03-19 潍坊医学院 一种针对新冠病毒棘突蛋白非rbd区的单克隆抗体及其应用
IL297977A (en) 2020-05-17 2023-01-01 Astrazeneca Uk Ltd Sars-cov-2 antibodies and methods of selecting and using the same
CN111607003B (zh) 2020-05-21 2022-08-23 上海百英生物科技有限公司 一种SARS-CoV-2 N/S1(RBD)重组蛋白及制备方法和应用
CN111560399B (zh) 2020-05-22 2021-07-06 苏州君盟生物医药科技有限公司 细胞大规模瞬时转染方法
CN111574614A (zh) 2020-05-23 2020-08-25 湖南源品细胞生物科技有限公司 一种tcr富集克隆型及其获取方法与应用
JP2023527352A (ja) 2020-05-26 2023-06-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｓａｒｓ－ｃｏｖ－２－スパイク糖タンパク質抗体及び抗原結合断片
CN111748032B (zh) 2020-05-27 2021-03-16 江苏省疾病预防控制中心(江苏省公共卫生研究院) 抗新型冠状病毒的抗体和使用该抗体的免疫检测
US20210371503A1 (en) 2020-05-29 2021-12-02 University Of Cologne Neutralizing antibodies against sars-related coronavirus
WO2021245184A1 (en) 2020-06-02 2021-12-09 Neurimmune Ag HUMAN ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-CoV-2)
CN111647077B (zh) 2020-06-02 2021-02-09 深圳市因诺赛生物科技有限公司 新型冠状病毒(sars-cov-2)刺突蛋白结合分子及其应用
AU2021283349A1 (en) 2020-06-03 2023-02-02 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing SARS-CoV-2 infections and COVID-19 with anti-SARS-CoV-2 spike glycoprotein antibodies
CN113429478B (zh) 2020-06-04 2023-11-10 山东宽和正生物医药有限公司 针对新冠病毒SARS-CoV-2的单克隆抗体H9
WO2021249547A1 (en) 2020-06-12 2021-12-16 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-coronavirus antibodies and uses thereof
CN113151184B (zh) 2020-06-15 2023-03-21 上海市公共卫生临床中心 基于细胞膜展示冠状病毒免疫原以诱导中和抗体的方法
CN111499692B (zh) 2020-06-16 2020-12-04 国家纳米科学中心 靶向新型冠状病毒covid-19的多肽及其应用
CN111825762A (zh) 2020-06-17 2020-10-27 武汉华美生物工程有限公司 抗sars-cov-2病毒s蛋白rbd结构域的纳米抗体及其用途
CN111848751B (zh) 2020-06-18 2023-09-29 河南省生物工程技术研究中心 一种新冠病毒s蛋白优势抗原表位肽及其用途
CN112521494B (zh) 2020-06-19 2021-06-25 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体2B11
CN111718411B (zh) 2020-06-19 2022-03-08 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体1F2
CN111690059B (zh) 2020-06-19 2022-03-08 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体1D7
CN111732654B (zh) 2020-06-19 2021-05-25 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体1E10
US11020474B1 (en) 2020-06-25 2021-06-01 Abclonal Science, Inc. Producing recombinant SARS-CoV-2 spike protein in a pre-fusion state
CN111714621B (zh) 2020-06-29 2021-04-27 中国科学院昆明动物研究所 转铁蛋白、转铁蛋白受体及其抗体在制备抗SARS-CoV-2病毒的药物中的应用
CN111732655B (zh) 2020-07-01 2021-10-22 中国人民解放军军事科学院军事医学研究院 靶向RBD的高中和活性抗SARS-CoV-2全人源单克隆抗体及应用
CN111848789B (zh) 2020-07-02 2022-04-22 武汉华美生物工程有限公司 抗sars-cov-2病毒s蛋白的单链抗体及其用途
CN111690060A (zh) 2020-07-06 2020-09-22 深圳市亚辉龙生物科技股份有限公司 能够特异性识别RBD蛋白的IgA抗体以及试剂盒
CN111732664B (zh) 2020-07-06 2020-12-01 北京金智准科技有限公司 一种新型冠状病毒重组蛋白、兔-人嵌合抗体、其制备方法及应用
CN111978377B (zh) 2020-07-09 2022-05-31 苏州和锐生物科技有限公司 Covid-19抗原、制备方法和应用
CN113072640A (zh) 2020-07-16 2021-07-06 深圳市雅臣智能生物工程有限公司 抗突变SARS-CoV-2多结合位点IgY及其制备以及抗体组合疗法和应用
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GB202017058D0 (en) 2020-10-27 2020-12-09 Kymab Ltd Antibodies and uses thereof
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WO2022162587A1 (en) 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
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