SG11202103404PA - Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments - Google Patents

Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Info

Publication number
SG11202103404PA
SG11202103404PA SG11202103404PA SG11202103404PA SG11202103404PA SG 11202103404P A SG11202103404P A SG 11202103404PA SG 11202103404P A SG11202103404P A SG 11202103404PA SG 11202103404P A SG11202103404P A SG 11202103404PA SG 11202103404P A SG11202103404P A SG 11202103404PA
Authority
SG
Singapore
Prior art keywords
cov
sars
antigen
binding fragments
spike glycoprotein
Prior art date
Application number
SG11202103404PA
Inventor
Robert Babb
Alina Baum
Gang Chen
Cindy Gerson
Johanna Hansen
Tammy Huang
Christos Kyratsous
Wen-Yi Lee
Marine Malbec
Andrew Murphy
William Olson
Neil Stahl
George Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202103404PA publication Critical patent/SG11202103404PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
SG11202103404PA 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments SG11202103404PA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063004312P 2020-04-02 2020-04-02
US202063014687P 2020-04-23 2020-04-23
US202063025949P 2020-05-15 2020-05-15
US202063034865P 2020-06-04 2020-06-04
PCT/US2020/039707 WO2021045836A1 (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Publications (1)

Publication Number Publication Date
SG11202103404PA true SG11202103404PA (en) 2021-04-29

Family

ID=72614999

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202103404PA SG11202103404PA (en) 2020-04-02 2020-06-25 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Country Status (28)

Country Link
US (5) US10787501B1 (en)
EP (2) EP3889177B1 (en)
JP (3) JP7116256B1 (en)
KR (1) KR20210134300A (en)
AU (1) AU2020340881A1 (en)
CA (2) CA3192925A1 (en)
CL (2) CL2021000997A1 (en)
CO (1) CO2021005072A2 (en)
CR (1) CR20220552A (en)
DK (1) DK3889177T5 (en)
ES (1) ES2939895T3 (en)
FI (1) FI3889177T3 (en)
HR (1) HRP20230338T1 (en)
HU (1) HUE061425T2 (en)
IL (1) IL282060A (en)
LT (1) LT3889177T (en)
MA (1) MA54405B1 (en)
MX (1) MX2021004130A (en)
MY (1) MY197648A (en)
PE (1) PE20221893A1 (en)
PH (1) PH12021550793A1 (en)
PL (1) PL3889177T3 (en)
PT (1) PT3889177T (en)
RS (1) RS64105B1 (en)
SG (1) SG11202103404PA (en)
SI (1) SI3889177T1 (en)
TW (1) TWI785350B (en)
WO (1) WO2021045836A1 (en)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014159990A1 (en) 2013-03-13 2014-10-02 Yale University Interferon production using short rna duplexes
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
ES2957939T3 (en) 2017-04-13 2024-01-30 Valneva Austria Gmbh Multivalent OspA polypeptides and methods and uses related thereto
CN114787928A (en) 2019-11-12 2022-07-22 雷杰纳荣制药公司 Methods and systems for identifying, classifying and/or ordering genetic sequences
US20230090311A1 (en) * 2020-01-09 2023-03-23 The University Of Queensland Self-assembling, self-adjuvanting system for delivery of vaccines
AU2021227687B2 (en) 2020-02-26 2023-02-23 Vir Biotechnology, Inc. Antibodies against SARS-CoV-2 and methods of using the same
WO2021178623A1 (en) * 2020-03-05 2021-09-10 New York Blood Center, Inc. Immunogenic compositions against severe acute respiratory syndrome coronavirus 2
US11365239B2 (en) * 2020-03-20 2022-06-21 Tsb Therapeutics (Beijing) Co., Ltd. Anti-SARS-COV-2 antibodies and uses thereof
WO2021190980A1 (en) * 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
WO2021194896A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 2ghw
WO2021194886A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 3bgf
WO2021194891A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from cr3022
WO2021194985A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 6nb6
WO2021194965A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Superhuman anti-sars-cov-2 antibodies and uses thereof
WO2021194951A1 (en) * 2020-03-23 2021-09-30 Centivax, Inc. Anti-sars-cov-2 antibodies derived from 2dd8
CN111349150B (en) * 2020-03-24 2021-02-09 北京中科微盾生物科技有限责任公司 Polypeptide for inhibiting novel coronavirus and application thereof
AU2020340881A1 (en) 2020-04-02 2021-10-21 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
WO2021198999A1 (en) * 2020-04-03 2021-10-07 Axon Neuroscience Se Epitope-based vaccines for treatment of coronavirus associated diseases
CA3174599A1 (en) * 2020-04-09 2021-10-14 Robert Schlegl Improvements in vaccine formulations for medical use
WO2021217062A1 (en) * 2020-04-24 2021-10-28 Kevin Fialko Sars-cov-2 susceptibility detection
CN115461364A (en) * 2020-04-28 2022-12-09 北京大学 Monoclonal antibody for resisting novel coronavirus and application thereof
JP7038367B2 (en) * 2020-05-01 2022-03-18 花王株式会社 Anti-SARS-CoV-2 antibody
US20230168249A1 (en) * 2020-05-06 2023-06-01 Academia Sinica Recombinant antibodies, kits comprising the same, and uses thereof
US20230357364A1 (en) * 2020-05-06 2023-11-09 International Aids Vaccine Initiative, Inc. Covid-19 antibodies and uses thereof
WO2021222988A1 (en) * 2020-05-07 2021-11-11 Griffith University Cell entry-modulating agents and uses therefor
CN116075315A (en) 2020-05-08 2023-05-05 刘扶东 Chimeric influenza vaccine
WO2021231659A1 (en) * 2020-05-12 2021-11-18 Sapphire Biotech, Inc. Neutralizing antibody testing and treatment
AU2021282179A1 (en) 2020-05-26 2023-01-19 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
CN116057069A (en) 2020-06-03 2023-05-02 瑞泽恩制药公司 Methods of treating or preventing SARS-CoV-2 infection and COVID-19 using anti-SARS-CoV-2 spike glycoprotein antibodies
EP4176262A1 (en) 2020-07-02 2023-05-10 King Abdullah University Of Science And Technology Nanobody functionalized electrochemical transistors and methods of making and using thereof
IL299630A (en) 2020-07-06 2023-03-01 Flagship Pioneering Innovations Vi Llc Antigen binding molecules targeting sars-cov-2
US11740240B2 (en) * 2020-07-20 2023-08-29 Bio-Rad Laboratories, Inc. Immunoassay for SARS-CoV-2 neutralizing antibodies and materials therefor
US20230295274A1 (en) 2020-07-27 2023-09-21 Single Cell Technology, Inc. Anti-sars coronavirus-2 spike protein antibodies
WO2022026592A2 (en) 2020-07-28 2022-02-03 Celltas Bio, Inc. Antibody molecules to coronavirus and uses thereof
CN111978378B (en) * 2020-08-10 2022-02-01 武汉大学 SARS-CoV-2 antigen polypeptide and its application
EP4206224A1 (en) * 2020-08-26 2023-07-05 National University Corporation Kumamoto University Human antibody or antigen-binding fragment thereof against coronavirus spike protein
KR20230058434A (en) 2020-08-26 2023-05-03 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 Antigen binding molecules targeting SARS-CoV-2
US20220074882A1 (en) * 2020-09-04 2022-03-10 Fraunhofer Usa, Inc. Electrochemical-based sensor for rapid and direct detection of sars-cov-2
WO2022054068A1 (en) * 2020-09-14 2022-03-17 Ramot At Tel-Aviv University Ltd. Antibodies for the prevention, treatment and detection of coronavirus infection
CN116710555A (en) * 2020-09-14 2023-09-05 南京诺唯赞生物科技股份有限公司 Neutralizing antibodies against SARS-COV-2
WO2022060916A1 (en) 2020-09-15 2022-03-24 Regenxbio Inc. Vectorized antibodies for anti-viral therapy
TWI796597B (en) * 2020-09-21 2023-03-21 長庚大學 Method against coronavirus infection with water-extracted product of perilla frutescens
CN112125973B (en) * 2020-09-30 2022-02-01 上海市公共卫生临床中心 Specific antibodies or antigen-binding fragments thereof for coronaviruses
CN116063464A (en) * 2020-09-30 2023-05-05 上海市公共卫生临床中心 Antibodies or antigen binding fragments thereof to coronaviruses
CN116419971A (en) * 2020-09-30 2023-07-11 南京金斯瑞生物科技有限公司 Monoclonal antibody against SARS-CoV-2 spike protein outer region and application thereof
WO2022072654A1 (en) * 2020-09-30 2022-04-07 The Research Foundation For The State University Of New York Particle based formulations of sars-cov-2 receptor binding domain
WO2022068844A1 (en) * 2020-09-30 2022-04-07 Vazyme Biotech Co., Ltd. Neutralizing antibody against sars-cov-2
CN112175073B (en) * 2020-09-30 2022-08-02 上海市公共卫生临床中心 Neutralizing antibodies or antigen-binding fragments thereof to coronaviruses
AR123688A1 (en) * 2020-10-02 2023-01-04 Lilly Co Eli METHODS TO REDUCE THE PROTEIN CONTENT OF THE HOST CELL IN PROTEIN PURIFICATION PROCESSES
WO2022075921A1 (en) * 2020-10-08 2022-04-14 Hummingbird Bioscience Holdings Limited Sars-cov-2 spike protein antigen-binding molecules
CN112251414A (en) * 2020-10-12 2021-01-22 中国科学院苏州纳米技术与纳米仿生研究所 Hybridoma cell strain, preparation method and application thereof
WO2022079606A1 (en) * 2020-10-12 2022-04-21 Icosagen Cell Factory Oü Sars cov-2 neutralizing antibodies
WO2022081436A1 (en) * 2020-10-15 2022-04-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods
CN112194711A (en) * 2020-10-15 2021-01-08 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） B cell linear epitope of novel coronavirus S protein, antibody, identification method and application
EP4228697A1 (en) 2020-10-16 2023-08-23 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
WO2022084817A1 (en) * 2020-10-19 2022-04-28 Lay Sciences Inc. Protein drugs for prevention and treatment of covid-19
GB202016650D0 (en) * 2020-10-20 2020-12-02 Primer Design Ltd Kit and method
WO2022087127A1 (en) * 2020-10-20 2022-04-28 Duke University Replication incompetent influenza vaccine platform for foreign protein delivery
US20230398204A1 (en) * 2020-10-21 2023-12-14 La Jolla Institute For Immunology Coronavirus Spike Glycoprotein With Improved Expression and Stability
CN112409488B (en) * 2020-10-23 2022-07-01 中国科学院上海药物研究所 Monoclonal antibody aiming at various coronaviruses and application
US20240025971A1 (en) * 2020-10-23 2024-01-25 Atreca, Inc. Antibodies to coronavirus sars-cov-2
KR20220054080A (en) * 2020-10-23 2022-05-02 주식회사 와이바이오로직스 ANTIBODY SPECIFICALLY BINDING TO SARS-CoV-2 SPIKE PROTEIN AND USES THEREOF
US20230391852A1 (en) * 2020-10-26 2023-12-07 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting sars coronavirus spike protein and uses thereof
US20240018191A1 (en) * 2020-10-27 2024-01-18 The University Of North Carolina At Chapel Hill Chimeric coronavirus s protein compositions and methods of use
WO2022094011A1 (en) * 2020-10-30 2022-05-05 Massachusetts Institute Of Technology Novel sars-cov-2 antigens and uses thereof
EP4237443A1 (en) * 2020-10-30 2023-09-06 Adaptive Biotechnologies Corp. Anti-sars-cov-2 antigen antibodies and related compositions and methods
WO2022094009A1 (en) * 2020-10-30 2022-05-05 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Single domain antibodies to sars-cov-2 nucleocapsid protein
EP4237586A4 (en) * 2020-10-30 2024-10-23 Achelois Biopharma Inc Multivalent particles compositions and methods of use
CN112358533B (en) * 2020-10-30 2023-07-14 上海泽润生物科技有限公司 Recombinant spike protein and preparation method and application thereof
US20240059760A1 (en) * 2020-11-02 2024-02-22 The University Of Chicago Polypeptides for detection and treatment of sars-cov-2
IL302645A (en) * 2020-11-03 2023-07-01 The Wistrar Inst Of Anatomy And Biology Dna encoded nanoparticles and method of use thereof as a coronavirus disease 2019 (covid-19) vaccine
CN112098660B (en) * 2020-11-03 2021-02-09 北京百普赛斯生物科技股份有限公司 Novel coronavirus neutralizing antibody detection kit
TW202227481A (en) * 2020-11-04 2022-07-16 美國洛克菲勒大學 Neutralizing anti-sars-cov-2 antibodies
TW202233233A (en) * 2020-11-06 2022-09-01 醣基生醫股份有限公司 Immune composition comprising antigen and glycoengineered antibody thereof
KR20220061903A (en) * 2020-11-06 2022-05-13 주식회사 녹십자 Antibodies specific for coronavirus spike protein and uses thereof
WO2022095045A1 (en) * 2020-11-09 2022-05-12 上海济煜医药科技有限公司 Sars-cov-2 antibody and application thereof
WO2022101839A1 (en) * 2020-11-12 2022-05-19 Cadila Healthcare Limited Anti-sars-cov-2 monoclonal antibodies and cocktail thereof
WO2022102744A1 (en) * 2020-11-13 2022-05-19 株式会社ハカレル Antibody against spike protein of sars-cov-2
CN112625136B (en) * 2020-11-18 2022-02-11 三优生物医药(上海)有限公司 Bispecific antibodies having neutralizing activity against coronaviruses and uses thereof
CN112409479B (en) * 2020-11-23 2022-04-26 中国疾病预防控制中心病毒病预防控制所 Humanized anti-neocoronavirus neutralizing antibody nCoV-121 and application thereof
JP2023554592A (en) * 2020-11-23 2023-12-28 ジェネンテック， インコーポレイテッド Methods for modulating the interaction of SARS-COV-2 with the surface of host cells
EP4251152A1 (en) * 2020-11-25 2023-10-04 Deciphera Pharmaceuticals, LLC Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection
CN112442120A (en) * 2020-11-25 2021-03-05 苏州大学 Neutralizing antibody against SARS-COV-2 of severe acute respiratory syndrome type II coronavirus
CN117241829A (en) * 2020-11-25 2023-12-15 德西费拉制药有限责任公司 Antiviral Activity of VPS34 inhibitors
CN112439058A (en) * 2020-11-25 2021-03-05 深圳市第二人民医院(深圳市转化医学研究院) Recombinant novel coronavirus nano vaccine method based on exosome as vector
WO2022115562A1 (en) * 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
WO2022112392A1 (en) 2020-11-26 2022-06-02 Memo Therapeutics Ag Anti-sars-cov-2 antibody molecules
US20220177982A1 (en) 2020-12-03 2022-06-09 Regeneron Pharmaceuticals, Inc. Methods Of Identifying Subjects Having An Increased Risk Of Developing A Coronavirus Infection And Treatment Thereof
WO2022122788A1 (en) * 2020-12-09 2022-06-16 Institute For Research In Biomedicine Multispecific antibodies against severe acute respiratory syndrome coronavirus 2
WO2022125789A1 (en) * 2020-12-09 2022-06-16 Yale University Compositions and methods for treating, ameliorating, and/or preventing viral infections
WO2022126119A2 (en) * 2020-12-09 2022-06-16 The University Of Chicago Methods and systems for detection and analysis of angiotensin binding antibodies
US11693011B2 (en) * 2020-12-14 2023-07-04 Inbios International, Inc. Neutralizing antibody immunoassays
WO2022132887A1 (en) * 2020-12-15 2022-06-23 Board Of Regents, The University Of Texas System Human monoclonal antibodies targeting the sars-cov-2 spike protein
WO2022132904A1 (en) * 2020-12-17 2022-06-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies targeting sars-cov-2
TW202241942A (en) * 2020-12-21 2022-11-01 日商中外製藥股份有限公司 Sars-cov-2 binding molecules and uses thereof
EP4267611A1 (en) * 2020-12-23 2023-11-01 Garvan Institute of Medical Research Sars-cov-2 antibodies
CN112794884B (en) * 2020-12-28 2022-02-18 中国科学院微生物研究所 Novel coronavirus protein, preparation method and neutralizing antibody detection kit
CN112326973B (en) * 2020-12-31 2021-03-23 北京金沃夫生物工程科技有限公司 Kit for detecting novel coronavirus antibody and application thereof
US20240294613A1 (en) * 2020-12-31 2024-09-05 The Broad Institute, Inc. Cross-neutralizing sars-cov2 antibodies
US11834493B2 (en) * 2021-01-05 2023-12-05 Immunome, Inc. Antibody cocktail against SARS-CoV-2 spike protein
TW202241928A (en) * 2021-01-08 2022-11-01 美商１０Ｘ基因組學有限公司 Antigen-binding polypeptides specific for coronaviruses and uses thereof
WO2022158497A1 (en) * 2021-01-22 2022-07-28 株式会社mAbProtein ANTIBODY AGAINST SPIKE PROTEIN OF SARS-CoV-2
US20240301037A1 (en) * 2021-01-22 2024-09-12 La Jolla Institute For Immunology Chimeric anti-coronavirus spike protein antibodies
WO2022162587A1 (en) * 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
CA3206260A1 (en) * 2021-01-28 2022-08-04 Ilse Roodink Anti-sars-cov-2 spike glycoprotein antibodies and the therapeutic use thereof
CN113264998B (en) * 2021-01-28 2023-02-28 四川大学华西医院 Single-chain antibody of S1 protein on surface of anti-new coronavirus SARS-CoV-2 and application thereof
CN115109150B (en) * 2021-01-31 2024-06-25 中南大学湘雅医院 Novel coronavirus monoclonal antibody XY10 and application thereof
RU2771288C1 (en) * 2021-02-02 2022-04-29 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации STRAIN OF HYBRID ANIMAL CELLS MUS MUSCULUS 2E1B5 - PRODUCER OF A MONOCLONAL ANTIBODY AGAINST THE RECEPROT-BINDING DOMAIN OF PROTEIN S OF THE SARS-CoV-2 VIRUS
US20240036054A1 (en) * 2021-02-04 2024-02-01 Rq Biotechnology Limited Antibodies
JP2024506315A (en) * 2021-02-09 2024-02-13 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ Antibodies that target the coronavirus spike protein
EP4291212A1 (en) 2021-02-15 2023-12-20 LivingMed Biotech S.R.L. Genetically clostridium modifiedstrains expressing recombinant antigens and uses thereof
EP4297786A1 (en) * 2021-02-23 2024-01-03 Pandion Operations, Inc. Pd-1 antibodies, polypeptides and uses thereof
WO2022182662A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Compositions and methods for mapping antigen-binding molecule affinity to antigen regions of interest
CN113009153B (en) * 2021-02-25 2023-12-15 山东莱博生物科技有限公司 New coronavirus neutralizing antibody detection kit based on magnetic particle chemiluminescence and application thereof
US12024551B1 (en) * 2021-03-04 2024-07-02 National Technology & Engineering Solutions Of Sandia, Llc Coronavirus neutralizing humanized antibodies and uses thereof
WO2022197720A2 (en) * 2021-03-15 2022-09-22 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating coronavirus infection
CN112679605B (en) * 2021-03-15 2021-07-09 安源医药科技（上海）有限公司 Antibodies or antigen binding fragments thereof against novel coronavirus nucleocapsid proteins and uses thereof
EP4063384A1 (en) * 2021-03-23 2022-09-28 Ceinge Biotecnologie Avanzate SCarl Human neutralizing antigen specific proteins for spike-rbd of sars-cov-2
CN113092776A (en) * 2021-03-24 2021-07-09 苏州携创生物技术有限公司 SARS-CoV-2 neutralizing antibody detection kit
US20240301038A1 (en) * 2021-03-26 2024-09-12 Atreca, Inc. Antibodies to sars-cov-2
CN115141270A (en) * 2021-03-29 2022-10-04 深圳市康麦生物技术有限公司 Antibodies that specifically bind to novel coronaviruses
WO2022210830A1 (en) * 2021-03-30 2022-10-06 国立大学法人 富山大学 Anti-sars-cov-2 antibody
KR20220136945A (en) * 2021-04-01 2022-10-11 (주)셀트리온 SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN
KR20220138352A (en) * 2021-04-05 2022-10-12 주식회사 엘지화학 Vaccine Composition Against Coronavirus
WO2022220603A1 (en) * 2021-04-16 2022-10-20 고려대학교 산학협력단 Human antibody targeting covid-19 virus
WO2022224271A1 (en) * 2021-04-19 2022-10-27 Bharat Serums And Vaccines Limited Polyclonal antibodies against sars-cov-2 and implementations thereof
CN117940157A (en) * 2021-04-20 2024-04-26 D4实验室有限责任公司 Adjuvant-containing vaccine compositions and methods
WO2022226079A1 (en) * 2021-04-20 2022-10-27 Inbios International, Inc. Neutralizing antibodies against sars-cov-2
WO2022231320A1 (en) * 2021-04-27 2022-11-03 국민대학교산학협력단 Antibody binding specifically to sars-cov-2 s protein or antigen-binding fragment thereof, and uses thereof
KR102426782B1 (en) * 2021-04-27 2022-07-28 국민대학교산학협력단 Diagnostic composition or Kit comprising SARS-CoV-2 RBD antigen specific antibody
WO2022232262A2 (en) * 2021-04-28 2022-11-03 The Trustees Of Columbia University In The City Of New York Antibodies for the treatment and prevention of covid-19 and emerging variants
US20240226279A1 (en) * 2021-05-03 2024-07-11 Ohio State Innovation Foundation Human anti-coronavirus peptide vaccines and methods of their use
WO2022235960A1 (en) * 2021-05-06 2022-11-10 Sorrento Therapeutics, Inc. Neutralizing antibodies that bind variant sars-cov-2 spike proteins
WO2022241057A1 (en) * 2021-05-12 2022-11-17 Applied Biomedical Science Institute Binding polypeptides against sars cov-2 and uses thereof
CN112981011B (en) * 2021-05-12 2021-08-17 广东凯普生物科技股份有限公司 Primer composition for detecting SARS-CoV-2 and its application
EP4089112A1 (en) * 2021-05-14 2022-11-16 Ustav organicke chemie a biochemie AV CR, v.v.i. Antibody binding to rbd of spike protein of sars-cov-2 and a method for quantifying protective antibodies against sars-cov-2
GB202107057D0 (en) 2021-05-18 2021-06-30 Univ York Glycosylation method
WO2022251403A1 (en) * 2021-05-28 2022-12-01 Icahn School Of Medicine At Mount Sinai Sars-cov-2 antibodies and uses thereof
CN113354733B (en) * 2021-06-04 2022-02-18 武汉生物制品研究所有限责任公司 Monoclonal antibody 20D8 for resisting SARS-CoV-2 epidemic mutant strain
CN113416245A (en) * 2021-06-15 2021-09-21 北京华大蛋白质研发中心有限公司 Neutralizing antibody capable of combining SARS-CoV-2 virus RBD protein and application thereof
WO2022263638A1 (en) * 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
US20230002478A1 (en) * 2021-06-22 2023-01-05 Twist Bioscience Corporation Methods and compositions relating to covid antibody epitopes
WO2022271258A1 (en) * 2021-06-25 2022-12-29 La Jolla Institute For Immunology Chimeric anti-sars-cov2 nucleoprotein antibodies
CN113584223B (en) * 2021-06-28 2024-01-12 中国人民解放军疾病预防控制中心 Identification method of D614G mutation in SARS-CoV-2 based on CRISPR-Cas12a
WO2023275538A1 (en) * 2021-06-28 2023-01-05 Diosynvax Ltd Beta-coronavirus vaccines
JP2024527344A (en) 2021-07-05 2024-07-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Using antibodies to match antibody responses to antigens
CA3225575A1 (en) * 2021-07-14 2023-01-19 Regeneron Pharmaceuticals, Inc. Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
WO2023285620A2 (en) * 2021-07-14 2023-01-19 Alchemab Therapeutics Ltd. Compositions and methods for targeting viral proteins
CN113621651A (en) * 2021-07-19 2021-11-09 南昌五元生物科技有限公司 Cell syncytium lesion model based on S-TET protein expression system and preparation method thereof
GB202110391D0 (en) 2021-07-19 2021-09-01 Tissue Click Ltd A detection kit and methods of detection of infectious agents
WO2023002944A1 (en) * 2021-07-19 2023-01-26 公立大学法人福島県立医科大学 Antibody capable of binding to novel coronavirus (sars-cov-2) and sars coronavirus (sars-cov)
CA3227150A1 (en) * 2021-07-23 2023-01-26 The Trustees Of Columbia University In The City Of New York Characterization of potent and broadly neutralizing monoclonal antibodies against sars-cov-2, its variants, and related coronaviruses and methods of use
US11724077B2 (en) * 2021-07-28 2023-08-15 Subhash Dhawan Therapeutic swabs for treating upper respiratory infections
WO2023008463A1 (en) * 2021-07-28 2023-02-02 株式会社イーベック Neutralizing human antibody against wild type strain and mutant strain of sars-cov-2 and antigen-binding fragment thereof
WO2023004477A1 (en) * 2021-07-30 2023-02-02 The University Of Melbourne Neutralising antibodies and uses thereof
CN113512113B (en) * 2021-08-03 2024-07-05 浙江大学医学院附属第一医院 Humanized broad-spectrum high-neutralization activity anti-novel coronavirus monoclonal antibody and application thereof
WO2023015232A1 (en) * 2021-08-04 2023-02-09 The Regents Of The University Of California Sars-cov-2 virus-like particles
WO2023023183A2 (en) * 2021-08-17 2023-02-23 Twist Bioscience Corporation Sars-cov-2 antibodies and related compositions and methods of use
WO2023026207A1 (en) * 2021-08-25 2023-03-02 Translational Health Science And Technology Institute Potently neutralizing novel human monoclonal antibodies against sars-cov-2 (covid-19)
WO2023035016A1 (en) * 2021-09-03 2023-03-09 The Uab Research Foundation Human neutralizing antibodies against sars-cov-2 spike s2 domain and uses thereof
KR20230038626A (en) * 2021-09-06 2023-03-21 국민대학교산학협력단 Bispecific antibody specifically targeting SARS-CoV-2
WO2023048656A2 (en) * 2021-09-24 2023-03-30 Chulalongkorn University Human monoclonal antibodies against the receptor-binding domain of sars-cov-2 spike protein
TW202334429A (en) * 2021-10-01 2023-09-01 中央研究院 Antibody specific to spike protein of sars-cov-2 and uses thereof
WO2023064717A2 (en) * 2021-10-08 2023-04-20 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof
WO2023064435A2 (en) * 2021-10-15 2023-04-20 The Children's Medical Center Corporation Compositions and methods relating to sars-cov-2 neutralizing antibodies
WO2023070029A1 (en) * 2021-10-20 2023-04-27 Arizona Board Of Regents On Behalf Of Arizona State University DNA ORIGAMI SUBUNIT VACCINE FOR PREVENTION OF SARS-CoV-2 VARIANT INFECTION
WO2023081434A2 (en) * 2021-11-07 2023-05-11 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies
WO2023084055A1 (en) * 2021-11-12 2023-05-19 Rq Biotechnology Limited Compositions
WO2023091920A1 (en) * 2021-11-16 2023-05-25 The University Of Chicago Polypeptides for detection and treatment of coronavirus infection
IL313010A (en) * 2021-12-01 2024-07-01 Universit?T Zu K?Ln Neutralizing antibodies against sars-related coronavirus
EP4190810A1 (en) * 2021-12-01 2023-06-07 Universität zu Köln Neutralizing antibodies against sars-related coronavirus
CN113862286B (en) * 2021-12-03 2022-03-04 艾棣维欣(苏州)生物制药有限公司 DNA molecule for coding SARS-COV-2 virus C.37 mutant strain antigen, DNA vaccine and application
WO2023104904A2 (en) * 2021-12-08 2023-06-15 Genclis The sars-cov-2 and variants use two independent cell receptors to replicate
CN116802496A (en) * 2021-12-14 2023-09-22 杭州安旭生物科技股份有限公司 Neutralizing antibody capable of combining SARS-CoV-2 virus and application thereof
WO2023113094A1 (en) * 2021-12-16 2023-06-22 주식회사 씨티씨백 Covid-19 vaccine composition with increased immunogenicity
WO2023122535A2 (en) * 2021-12-20 2023-06-29 DNARx Nucleic acid expression using subcutaneous administration
WO2023129928A2 (en) * 2021-12-27 2023-07-06 Academia Sinica Antibody specific to spike protein of sars-cov-2 and uses thereof
US20230277682A1 (en) 2022-01-14 2023-09-07 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof
TW202346329A (en) * 2022-01-26 2023-12-01 中央研究院 Antibody specific to coronaviruses and uses thereof
JPWO2023145859A1 (en) 2022-01-28 2023-08-03
WO2023152188A1 (en) * 2022-02-11 2023-08-17 Attana Ab Analytical method
WO2023156186A1 (en) * 2022-02-16 2023-08-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Markers for high-affinity sars-cov-2 spike protein antibodies
TW202342510A (en) * 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 Antibodies
CN114231497B (en) * 2022-02-24 2022-05-20 广州伯尼兹生物科技有限公司 Monoclonal antibody hybridoma cell line expressing SARS-CoV-2S 1 protein and neutralizing active antibody
WO2023178182A1 (en) * 2022-03-16 2023-09-21 10X Genomics, Inc. Compositions and methods for detection and treatment of coronavirus infection
WO2023190852A1 (en) * 2022-03-31 2023-10-05 公立大学法人福島県立医科大学 Antibody capable of binding to new coronavirus (sars-cov-2)
WO2023190851A1 (en) * 2022-03-31 2023-10-05 公立大学法人福島県立医科大学 Antibody binding to novel coronavirus (sars-cov-2)
US11993644B2 (en) 2022-05-06 2024-05-28 Generate Biomedicines, Inc. Antigen binding molecules targeting SARS-CoV-2
EP4335870A1 (en) * 2022-09-06 2024-03-13 NantCell, Inc. Peptide therapeutics against sars-cov-2 spike protein
EP4349860A1 (en) 2022-10-06 2024-04-10 Fundació Institut Hospital Del Mar D'Investigacions Mèdiques (IMIM) Anti-sars-cov-2 antibodies
TW202426045A (en) * 2022-10-07 2024-07-01 高端疫苗生物製劑股份有限公司 Immunogenic compositions against the omicron variant of severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
WO2024182451A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. Multivalent anti-spike protein binding molecules and uses thereof
WO2024182455A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. Multivalent anti-spike protein binding molecules and uses thereof
CN117379399A (en) * 2023-06-27 2024-01-12 江生(深圳)生物技术研发中心有限公司 Horse-derived immunoglobulin inhalation liquid formulation and preparation and use methods thereof

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CN1914226B (en) 2003-11-25 2012-02-01 达纳-法伯癌症研究院有限公司 Antibodies against SARS-COV and methods of use thereof
US7629443B2 (en) 2004-06-02 2009-12-08 New York Blood Center, Inc. Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
PL2041177T3 (en) 2006-06-02 2012-09-28 Regeneron Pharma High affinity antibodies to human il-6 receptor
CA2666599A1 (en) 2006-08-18 2008-02-21 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
US9212226B2 (en) 2008-05-16 2015-12-15 Ablynx N.V. Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
WO2014022540A1 (en) 2012-08-02 2014-02-06 Regeneron Pharmaceuticals, Inc. Multivalent antigen-binding proteins
US9884895B2 (en) 2014-03-20 2018-02-06 The University Of North Carolina At Chapel Hill Methods and compositions for chimeric coronavirus spike proteins
JO3701B1 (en) 2014-05-23 2021-01-31 Regeneron Pharma Human antibodies to middle east respiratory syndrome – coronavirus spike protein
IL264631B2 (en) 2016-08-16 2024-05-01 Regeneron Pharma Methods for quantitating individual antibodies from a mixture
PL3638698T3 (en) 2018-01-26 2021-09-06 Regeneron Pharmaceuticals, Inc. Anti-tmprss2 antibodies and antigen-binding fragments
EP3993887B1 (en) 2019-07-03 2023-07-26 Merck Patent GmbH Glycoform purification
WO2021026074A1 (en) 2019-08-02 2021-02-11 University Of Virginia Patent Foundation Bispecific antibody targeting of t regulatory cells for treatment of inflammatory conditions
JP2022545106A (en) 2019-08-22 2022-10-25 シダラ セラピューティクス インコーポレーテッド Variant FC domains and uses thereof
EP3795163A1 (en) 2019-09-23 2021-03-24 The Ceutics Company GesmbH A topical plant extract formulation comprising urtica dioica and vitamin a
US12048741B2 (en) 2019-09-27 2024-07-30 George Mason University Recombinant host cell with heterologous nucleic acids encoding SHREK proteins
CN111748571B (en) 2019-10-11 2022-05-03 浙江禾霖生物科技有限公司 Method for engineering bacillus subtilis into multifunctional stable platform for producing nano antibody
CN114787928A (en) 2019-11-12 2022-07-22 雷杰纳荣制药公司 Methods and systems for identifying, classifying and/or ordering genetic sequences
WO2021148884A1 (en) 2020-01-24 2021-07-29 Tychan Pte. Ltd. Anti-wuhan coronavirus antibodies
NL2027383B1 (en) * 2020-01-24 2022-04-06 Aim Immunotech Inc Methods, compositions, and vaccines for treating a virus infection
CN113201068A (en) 2020-02-03 2021-08-03 深圳市雅臣智能生物工程有限公司 Gene recombination anti 2019-nCoV and other coronavirus IgY and small molecule antibody and application thereof
CA3166949A1 (en) 2020-02-11 2021-08-19 James E. Crowe Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
CN113248579B (en) 2020-02-12 2022-10-18 重庆医科大学 Novel coronavirus (2019-ncov) epitope, antibody and application thereof
CN111303254A (en) 2020-02-20 2020-06-19 北京新创生物工程有限公司 Novel coronavirus (SARS-CoV-2) antigen detection kit
DE202020105116U1 (en) 2020-02-20 2020-10-06 Charité - Universitätsmedizin Berlin Reagents and uses in diagnosing SARS-CoV-2 infection
WO2021168483A2 (en) * 2020-02-21 2021-08-26 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors
US20210260201A1 (en) 2020-02-21 2021-08-26 Physis Biotechnologies, Llc Extracellular vesicles for the treatment and prevention of infections and other diseases
CN113292649B (en) 2020-02-24 2022-08-12 中国科学院微生物研究所 Human monoclonal antibodies to novel coronaviruses and uses thereof
CN113292650B (en) 2020-02-24 2022-08-12 中国科学院微生物研究所 Human monoclonal antibodies to novel coronaviruses and uses thereof
CN111333704B (en) 2020-02-24 2021-01-12 军事科学院军事医学研究院微生物流行病研究所 Novel coronavirus COVID-19 vaccine, preparation method and application thereof
JP2023514452A (en) 2020-02-25 2023-04-05 リガンダル・インコーポレイテッド Identification of biomimetic viral peptides and their use
AU2021227687B2 (en) 2020-02-26 2023-02-23 Vir Biotechnology, Inc. Antibodies against SARS-CoV-2 and methods of using the same
CN113307865B (en) 2020-02-26 2022-12-13 复旦大学 Fully human single domain antibody of novel coronavirus and application
EP3885361A1 (en) 2020-02-27 2021-09-29 Macrofarm Srl Monoclonal-type synthetic antibodies obtained by molecular imprinting and their use for the treatment and preventive medicine of covid-19
CN113354731A (en) 2020-03-02 2021-09-07 中国科学院微生物研究所 Human monoclonal antibodies to coronaviruses and uses thereof
CN111333722A (en) 2020-03-03 2020-06-26 江苏省疾病预防控制中心(江苏省公共卫生研究院) SARS-CoV-2 inhibitor and its application
US11376320B2 (en) 2020-03-05 2022-07-05 Iowa State University Research Foundation, Inc. Immunogenic and vaccine compositions against SARS-CoV-2
MX2022011142A (en) 2020-03-09 2022-12-13 Abcellera Biologics Inc Anti-coronavirus antibodies and methods of use.
CN111285933A (en) 2020-03-09 2020-06-16 四川省人民医院 Novel coronavirus antigen colloidal gold diagnostic kit
US20210277093A1 (en) 2020-03-09 2021-09-09 Adma Biologics, Inc. Immunotherapeutic compositions and methods of production for coronavirus
CN111420048B (en) 2020-03-11 2023-09-19 中国人民解放军第四军医大学 Application of anti-BASIGAN humanized antibody in preparation of medicine for treating novel coronavirus pneumonia
US10822379B1 (en) 2020-03-12 2020-11-03 University of Pittsburgh—of the Commonwealth System of Higher Education Molecules that bind to SARS-CoV-2
GB202003632D0 (en) 2020-03-12 2020-04-29 Harbour Antibodies Bv SARS-Cov-2 (SARS2, COVID-19) antibodies
WO2021183790A1 (en) 2020-03-12 2021-09-16 Rigel Pharmaceuticals, Inc. Method for treatment of covid-19-associated conditions
CN112557645B (en) 2020-03-13 2022-03-08 珠海碳云智能科技有限公司 Method and device for screening epitope polypeptides
CN111592594B (en) 2020-03-13 2022-05-10 北京大学 Monoclonal antibody for resisting novel coronavirus and application thereof
CN114163523B (en) 2020-03-17 2023-07-18 北京凯因科技股份有限公司 Single-domain antibody for novel coronavirus and application thereof
CN111088283B (en) * 2020-03-20 2020-06-23 苏州奥特铭医药科技有限公司 mVSV viral vector, viral vector vaccine thereof and mVSV-mediated novel coronary pneumonia vaccine
KR102205028B1 (en) 2020-03-22 2021-01-20 (주)셀트리온 A binding molecules able to neutralize SARS-CoV-2
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
CN111303280B (en) 2020-03-22 2022-01-07 中国人民解放军军事科学院军事医学研究院 High-neutralization-activity anti-SARS-CoV-2 fully human monoclonal antibody and application
US11021531B1 (en) 2020-03-23 2021-06-01 Centivax, Inc. Anti-SARS-Cov-2 antibodies derived from 2GHW
US11028167B1 (en) 2020-03-23 2021-06-08 Centivax, Inc. Anti-SARS-Cov-2 antibodies derived from 3bgf
US11021532B1 (en) 2020-03-23 2021-06-01 Centivax, Inc. Superhuman anti-SARS-CoV-2 antibodies and uses thereof
US11028150B1 (en) 2020-03-23 2021-06-08 Centivax, Inc. Anti-SARS-CoV-2 antibodies derived from 2DD8
CN111690058B (en) 2020-03-30 2021-02-05 三优生物医药(上海)有限公司 Antibodies with neutralizing activity against coronaviruses and uses thereof
CN111423508A (en) 2020-03-31 2020-07-17 江苏省疾病预防控制中心(江苏省公共卫生研究院) Separated SARS-CoV-2 protein binding molecule for resisting virus infection
CN111848750B (en) 2020-03-31 2023-09-12 浙江聚康生物工程有限公司 Method and kit for rapidly enriching and detecting 2019-nCoV
AU2020340881A1 (en) 2020-04-02 2021-10-21 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
WO2021203053A1 (en) 2020-04-03 2021-10-07 Vir Biotechnology, Inc. Immunotherapy targeting a conserved region in sars coronaviruses
CA3174212A1 (en) * 2020-04-03 2021-10-07 Blis Technologies Limited Antiviral treatment comprising blis containing probiotic products
CN111499765B (en) 2020-04-08 2022-04-08 四川携光生物技术有限公司 Coronavirus fusion protein and preparation method and application thereof
CN111440229B (en) 2020-04-13 2021-08-03 中国人民解放军军事科学院军事医学研究院 Novel coronavirus T cell epitope and application thereof
CN111647053A (en) 2020-04-16 2020-09-11 军事科学院军事医学研究院生命组学研究所 Polypeptide and application thereof in novel coronavirus detection and antibody or vaccine screening
CN111647076B (en) 2020-04-27 2021-02-26 南京医科大学 Neutralizing single-domain antibody for resisting novel coronavirus SARS-Cov-2 and application thereof
CN111592595B (en) 2020-04-27 2021-02-19 南京医科大学 Neutralizing antibody against novel coronavirus SARS-Cov-2 and application thereof
MX2021015024A (en) 2020-04-28 2022-01-18 Univ Rockefeller Neutralizing anti-sars-cov-2 antibodies and methods of use thereof.
CN111471105A (en) 2020-05-05 2020-07-31 广西医科大学 Preparation and application of novel coronavirus silver therapeutic neutralizing antibody
CA3177169A1 (en) 2020-05-08 2021-11-11 Vir Biotechnology, Inc. Antibodies against sars-cov-2
CN111620945B (en) 2020-05-09 2021-01-15 江苏省疾病预防控制中心(江苏省公共卫生研究院) Monoclonal antibody or derivative thereof for resisting novel coronavirus
CN111620946B (en) 2020-05-09 2020-12-22 江苏省疾病预防控制中心(江苏省公共卫生研究院) Isolated novel coronavirus monoclonal antibodies or antigen binding portions thereof
CN111662379B (en) 2020-05-09 2021-03-02 江苏省疾病预防控制中心(江苏省公共卫生研究院) Antibody for resisting novel coronavirus, preparation method and application
CN111518773B (en) 2020-05-09 2023-01-03 山东兴瑞生物科技有限公司 CAR-T cell for resisting novel coronavirus S protein, preparation method and application thereof
CN112010966B (en) 2020-05-15 2021-03-19 潍坊医学院 Monoclonal antibody aiming at non-RBD (radial basis function) region of new coronavirus spike protein and application thereof
MX2022014422A (en) 2020-05-17 2022-12-07 Astrazeneca Uk Ltd Sars-cov-2 antibodies and methods of selecting and using the same.
CN111607003B (en) 2020-05-21 2022-08-23 上海百英生物科技有限公司 SARS-CoV-2N/S1 (RBD) recombinant protein and its preparation method and application
CN111560399B (en) 2020-05-22 2021-07-06 苏州君盟生物医药科技有限公司 Large-scale transient transfection method for cells
CN111574614A (en) 2020-05-23 2020-08-25 湖南源品细胞生物科技有限公司 TCR enrichment clone type and acquisition method and application thereof
AU2021282179A1 (en) 2020-05-26 2023-01-19 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
CN111748032B (en) 2020-05-27 2021-03-16 江苏省疾病预防控制中心(江苏省公共卫生研究院) Antibody against novel coronavirus and immunoassay using the same
EP4157455A1 (en) 2020-05-29 2023-04-05 Universität zu Köln Neutralizing antibodies against sars-related coronavirus
US20230242624A1 (en) 2020-06-02 2023-08-03 Neurimmune Ag HUMAN ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-CoV-2)
CN111647077B (en) 2020-06-02 2021-02-09 深圳市因诺赛生物科技有限公司 Novel coronavirus (SARS-COV-2) spike protein binding molecule and application thereof
CN116057069A (en) 2020-06-03 2023-05-02 瑞泽恩制药公司 Methods of treating or preventing SARS-CoV-2 infection and COVID-19 using anti-SARS-CoV-2 spike glycoprotein antibodies
CN113429478B (en) 2020-06-04 2023-11-10 山东宽和正生物医药有限公司 Monoclonal antibody H9 against novel coronavirus SARS-CoV-2
WO2021249547A1 (en) 2020-06-12 2021-12-16 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-coronavirus antibodies and uses thereof
CN113151184B (en) 2020-06-15 2023-03-21 上海市公共卫生临床中心 Method for cell membrane-based display of coronavirus immunogens to induce neutralizing antibodies
CN111499692B (en) 2020-06-16 2020-12-04 国家纳米科学中心 Polypeptide of targeting novel coronavirus COVID-19 and application thereof
CN111825762A (en) 2020-06-17 2020-10-27 武汉华美生物工程有限公司 Nano antibody of S protein RBD structure domain of anti SARS-COV-2 virus and its use
CN111848751B (en) 2020-06-18 2023-09-29 河南省生物工程技术研究中心 Novel coronavirus S protein dominant antigen epitope peptide and application thereof
CN111690059B (en) 2020-06-19 2022-03-08 武汉生物制品研究所有限责任公司 Monoclonal antibody 1D7 for resisting SARS-CoV-2
CN111718411B (en) 2020-06-19 2022-03-08 武汉生物制品研究所有限责任公司 Monoclonal antibody 1F2 for resisting SARS-CoV-2
CN111732654B (en) 2020-06-19 2021-05-25 武汉生物制品研究所有限责任公司 Monoclonal antibody 1E10 for resisting SARS-CoV-2
CN112521494B (en) 2020-06-19 2021-06-25 武汉生物制品研究所有限责任公司 Monoclonal antibody 2B11 for resisting SARS-CoV-2
US11020474B1 (en) 2020-06-25 2021-06-01 Abclonal Science, Inc. Producing recombinant SARS-CoV-2 spike protein in a pre-fusion state
CN111714621B (en) 2020-06-29 2021-04-27 中国科学院昆明动物研究所 Application of transferrin, transferrin receptor and antibody thereof in preparing medicine for resisting SARS-CoV-2 virus
CN111732655B (en) 2020-07-01 2021-10-22 中国人民解放军军事科学院军事医学研究院 RBD-targeted high-neutralization-activity anti-SARS-CoV-2 fully-humanized monoclonal antibody and application thereof
CN111848789B (en) 2020-07-02 2022-04-22 武汉华美生物工程有限公司 Single chain antibody for resisting SARS-COV-2 virus S protein and its use
CN111732664B (en) 2020-07-06 2020-12-01 北京金智准科技有限公司 Novel coronavirus recombinant protein, rabbit-human chimeric antibody, preparation method and application thereof
CN111690060A (en) 2020-07-06 2020-09-22 深圳市亚辉龙生物科技股份有限公司 IgA antibody capable of specifically recognizing RBD protein and kit
CN111978377B (en) 2020-07-09 2022-05-31 苏州和锐生物科技有限公司 COVID-19 antigen, preparation method and application
CN113072640A (en) 2020-07-16 2021-07-06 深圳市雅臣智能生物工程有限公司 Anti-mutation SARS-CoV-2 multi-binding site IgY and its preparation and antibody combination therapy and application
CN114409773B (en) 2020-07-17 2024-02-27 上海洛启生物医药技术有限公司 Nanobody for novel coronavirus and application thereof
CN111978398B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Antibody against coronavirus SARS-COV-2 and medical use thereof
CN111978397B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Antibody specifically binding SARS-COV-2S protein and its use
CN112210004B (en) 2020-07-20 2021-06-29 江苏集萃医学免疫技术研究所有限公司 Coronavirus COVID-19 detection antibody and application thereof
CN112010963B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 SARS-COV-2 antibody and use thereof
CN111978395B (en) 2020-07-20 2022-06-10 四川大学 Monoclonal antibody against novel coronavirus RBD domain antigen
CN112010962B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Antibody for detecting COVID-19 and medical application thereof
CN111978399B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Antibody specifically binding SARS-COV-2 antigen protein and its use
CN111995672B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Specific antibody of coronavirus SARS-COV-2S protein and its use
CN111978396B (en) 2020-07-20 2022-05-20 江苏集萃医学免疫技术研究所有限公司 Antibody specifically binding SARS-COV-2 NP protein and its use
CN111825771A (en) 2020-07-23 2020-10-27 白涛 Antiviral antibacterial biological missile
CN112062859B (en) 2020-07-24 2022-08-09 沣潮医药科技（上海）有限公司 Chimeric antigen receptor for pathogen clearance and uses thereof
CN111793129B (en) 2020-07-28 2021-09-24 上海市公共卫生临床中心 Antibody or antigen binding fragment thereof specifically binding to coronavirus
CN112094340B (en) 2020-07-31 2023-06-20 王跃驹 Application of plant as host in expression of novel coronavirus pneumonia neutralizing antibody B38 antibody and/or H4 antibody
CN112300274B (en) 2020-08-10 2022-05-31 苏州方科生物科技有限公司 Human source antibody of novel coronavirus specific antigen peptide, preparation method and use
CN111875701A (en) 2020-08-14 2020-11-03 江苏中慧元通生物科技有限公司 Single-chain antibody of SARS-CoV-2 virus and its use
CN114989293B (en) 2020-08-19 2023-10-17 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN111925440B (en) 2020-08-19 2022-09-09 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN111925439A (en) 2020-08-19 2020-11-13 重庆医科大学 Method for rapidly screening new coronavirus RBD (radial basis function) specific fully human neutralizing monoclonal antibody
CN111944026B (en) 2020-08-19 2023-10-20 重庆医科大学 Linear antigen epitope of novel coronavirus RBD specific monoclonal antibody and application
CN115925898A (en) 2020-08-19 2023-04-07 重庆医科大学 Novel coronavirus RBD specific monoclonal antibody and application
CN115304671B (en) 2020-08-19 2023-10-17 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application thereof
CN114920833B (en) 2020-08-19 2023-10-17 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN115925897A (en) 2020-08-19 2023-04-07 重庆医科大学 Novel coronavirus RBD specific monoclonal antibody and application
CN111925442B (en) 2020-08-19 2022-10-11 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN111925441B (en) 2020-08-19 2022-10-04 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN118085068A (en) 2020-08-19 2024-05-28 重庆医科大学 New coronavirus RBD specific monoclonal antibody and application
CN112062838B (en) 2020-08-25 2021-03-23 南京医科大学 Neutralizing single-domain antibody for resisting novel coronavirus SARS-Cov-2 and application thereof
CN112010964A (en) 2020-09-02 2020-12-01 安第斯抗体生物技术衡水有限公司 Novel coronavirus alpaca antibody and preparation method and application thereof
CN111995674B (en) 2020-09-03 2022-02-11 中国人民解放军军事科学院军事医学研究院 anti-COVID-19 virus neutralizing antibody mhC3, humanized antibody and application thereof
KR102229225B1 (en) 2020-09-04 2021-03-19 (주)셀트리온 Binding Molecules Binding To A Spike Protein Of SARS-CoV-2 For Diagnosis Of COVID-19
CN112010967B (en) 2020-09-07 2021-03-23 康维众和(中山)生物药业有限公司 Novel nano antibody for neutralizing toxicity of coronavirus SARS-Cov-2 and preparation method and application thereof
CN112076316B (en) 2020-09-21 2022-10-11 中国人民解放军军事科学院军事医学研究院 Double-antibody composition and application thereof in preparation of COVID-19 therapeutic drugs
CN112062839A (en) 2020-09-22 2020-12-11 石河子大学 Nano antibody based on novel coronavirus S protein S1 subunit and application thereof
CN112062840A (en) 2020-09-22 2020-12-11 石河子大学 Nano antibody based on novel coronavirus S protein and application thereof
CN112175071A (en) 2020-09-22 2021-01-05 通用生物系统（安徽）有限公司 Preparation method of novel coronavirus spike protein monoclonal antibody
CN114276442B (en) 2020-09-23 2023-05-16 深圳市因诺赛生物科技有限公司 Novel coronavirus (SARS-COV-2) spike protein binding molecule and application thereof
CN112094342B (en) 2020-09-25 2022-05-13 中国科学技术大学 Alpaca source nano antibody combined with SARS-CoV-2RBD
CN112094327A (en) 2020-09-25 2020-12-18 军事科学院军事医学研究院军事兽医研究所 Truncation body based on novel coronavirus RBD-SD1 protein and application thereof
CN112094326B (en) 2020-09-25 2023-06-02 河南省生物工程技术研究中心 New coronavirus antigen and application thereof
CN112094343B (en) 2020-09-25 2022-05-13 中国科学技术大学 Alpaca source nano antibody combined with SARS-CoV-2 RBD
CN116063464A (en) 2020-09-30 2023-05-05 上海市公共卫生临床中心 Antibodies or antigen binding fragments thereof to coronaviruses
CN112175073B (en) 2020-09-30 2022-08-02 上海市公共卫生临床中心 Neutralizing antibodies or antigen-binding fragments thereof to coronaviruses
CN112125973B (en) 2020-09-30 2022-02-01 上海市公共卫生临床中心 Specific antibodies or antigen-binding fragments thereof for coronaviruses
CN112251414A (en) 2020-10-12 2021-01-22 中国科学院苏州纳米技术与纳米仿生研究所 Hybridoma cell strain, preparation method and application thereof
CN112194711A (en) 2020-10-15 2021-01-08 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） B cell linear epitope of novel coronavirus S protein, antibody, identification method and application
CN112409488B (en) 2020-10-23 2022-07-01 中国科学院上海药物研究所 Monoclonal antibody aiming at various coronaviruses and application
GB202017058D0 (en) 2020-10-27 2020-12-09 Kymab Ltd Antibodies and uses thereof
CN112851804B (en) 2020-11-13 2023-03-28 林国生 Neutralizing active monoclonal antibody of human source for resisting novel coronavirus (SARS-CoV-2)
CN112625136B (en) 2020-11-18 2022-02-11 三优生物医药(上海)有限公司 Bispecific antibodies having neutralizing activity against coronaviruses and uses thereof
RU2744274C1 (en) 2020-11-20 2021-03-04 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Monoclonal antibody to rdb fragment in composition of sars-cov-2 s protein
CN112430265B (en) 2020-11-23 2022-04-12 中国疾病预防控制中心病毒病预防控制所 Humanized anti-neocoronavirus neutralizing antibody nCoV-61 and application thereof
CN112522203B (en) 2020-11-23 2023-08-11 中山大学附属第五医院 Cell vesicle for expressing chimeric antigen receptor, and preparation method and application thereof
CN112409479B (en) 2020-11-23 2022-04-26 中国疾病预防控制中心病毒病预防控制所 Humanized anti-neocoronavirus neutralizing antibody nCoV-121 and application thereof
CN112341541B (en) 2020-11-23 2022-05-06 中国疾病预防控制中心病毒病预防控制所 Humanized anti-neocoronavirus neutralizing antibody nCoV-163 and application thereof
CN112574299B (en) 2020-11-25 2023-03-21 苏州方科生物科技有限公司 Human source antibody of novel coronavirus specific antigen peptide, preparation method and use
CN112442120A (en) 2020-11-25 2021-03-05 苏州大学 Neutralizing antibody against SARS-COV-2 of severe acute respiratory syndrome type II coronavirus
KR102233689B1 (en) 2020-11-26 2021-03-30 재단법인 오송첨단의료산업진흥재단 Antibodies specifically binding to receptor-binding domain of SARS-CoV-2 spike protein and use thereof
CN112500481B (en) 2020-11-29 2021-08-20 山西省人民医院 Human source neutralizing active monoclonal antibody for resisting novel coronavirus
CN112574300B (en) 2020-12-02 2022-03-08 深圳先进技术研究院 anti-SAR-COV-2 fully human monoclonal antibody and preparation method and application thereof
CN112661841B (en) 2020-12-04 2022-10-14 广州市第八人民医院 Fully human monoclonal antibody 17-2 for neutralizing neoepitope of new coronavirus and application thereof
CN112626089B (en) 2020-12-08 2022-03-11 杭州百凌生物科技有限公司 SARS-CoV-2 virus S protein receptor binding region coding gene, antibody and application
CN112538111B (en) 2020-12-09 2022-04-29 深圳市亚辉龙生物科技股份有限公司 New coronavirus single-chain antibody, quality control product and preparation method
CN112485455B (en) 2020-12-09 2022-11-01 深圳市亚辉龙生物科技股份有限公司 New coronavirus antibody quality control product and preparation method thereof
CN112250763B (en) 2020-12-21 2021-03-26 三优生物医药(上海)有限公司 Antibody targeting SARS-CoV-2 coronavirus and its diagnosis and detection use
CN112724247A (en) 2020-12-25 2021-04-30 江苏中方基因生物医学科技有限公司 SARS-CoV-2 coronavirus IgA antibody and its application in ELISA detection kit
CN112626030A (en) 2020-12-31 2021-04-09 深圳市第二人民医院 Production method for neutralizing new coronavirus by using nano antibody of spinous process protein Spike displayed on surface of exosome
CN112341542B (en) 2021-01-08 2021-05-14 清华大学 3-hydroxybutyrylated modified protein medicine and preparation method and application thereof
CN112625125B (en) 2021-01-18 2021-12-14 中国人民解放军军事科学院军事医学研究院 Monoclonal antibody for neutralizing novel coronavirus infection
CN112390879B (en) 2021-01-21 2021-04-02 上海科技大学 Antibody targeting SARS-CoV-2 and its preparation method and use
WO2022162587A1 (en) 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
CN112724248A (en) 2021-01-28 2021-04-30 南京拓峰生物科技有限公司 Nano antibody capable of combining SARS-CoV-2 and application thereof
CN113264998B (en) 2021-01-28 2023-02-28 四川大学华西医院 Single-chain antibody of S1 protein on surface of anti-new coronavirus SARS-CoV-2 and application thereof
CN113150129B (en) 2021-01-28 2023-02-28 四川大学华西医院 Single-chain antibody for resisting S2 protein on surface of new coronavirus SARS-CoV-2 and application thereof
CN112521496B (en) 2021-01-29 2022-09-06 中国人民解放军空军军医大学 Monoclonal antibody specifically binding SARS-CoV-2 Spike RBD and application thereof
CN115109150B (en) 2021-01-31 2024-06-25 中南大学湘雅医院 Novel coronavirus monoclonal antibody XY10 and application thereof
CN112552399B (en) 2021-02-24 2021-07-20 恒翼生物医药科技(上海)有限公司 anti-SARS-COV-2 neutralizing antibody
CN113150132B (en) 2021-03-11 2022-05-31 苏州携创生物技术有限公司 anti-SARS-CoV-2 recombinant antibody and its application
CN112794899B (en) 2021-03-16 2021-09-24 易康生物(苏州)有限公司 Fully human monoclonal neutralizing antibody for resisting novel coronavirus and application thereof
CN112794898B (en) 2021-03-16 2021-08-03 易康生物(苏州)有限公司 Fully human monoclonal antibody for resisting novel coronavirus and application thereof
CN112980885B (en) 2021-03-18 2022-04-15 恒翼生物医药科技(上海)有限公司 Expression vector of anti-SARS-COV-2 neutralizing antibody
CN113045647B (en) 2021-03-22 2022-04-26 南京传奇生物科技有限公司 Neutralizing antibody of novel coronavirus SARS-CoV-2 and application thereof
CN113150135B (en) 2021-04-14 2022-09-20 中山大学 Neutralizing antibodies against novel coronavirus receptor binding domains and uses thereof
CN113173995B (en) 2021-04-30 2022-09-23 上海市公共卫生临床中心 Bispecific antibody combined with coronavirus
CN113234149B (en) 2021-05-19 2023-06-16 武汉菲沙基因组医学有限公司 New fully human coronal IgA single-chain antibody and application thereof
CN113234150A (en) 2021-05-19 2021-08-10 武汉菲沙基因组医学有限公司 Fully human novel crown IgG1 single-chain antibody and application thereof
CN113185609A (en) 2021-05-19 2021-07-30 武汉菲沙基因组医学有限公司 Fully human novel crown IgG2 single-chain antibody and application thereof
CN113234148A (en) 2021-05-19 2021-08-10 武汉菲沙基因组医学有限公司 Fully human-derived novel crown IgK single-chain antibody and application thereof
CN113214389A (en) 2021-05-19 2021-08-06 武汉菲沙基因组医学有限公司 Fully human-derived novel crown IgL single-chain antibody and application thereof
CN113215106B (en) 2021-05-20 2022-04-01 广东省公共卫生研究院 Hybridoma cell, monoclonal antibody for resisting SARS-CoV-2 and application thereof
CN113354733B (en) 2021-06-04 2022-02-18 武汉生物制品研究所有限责任公司 Monoclonal antibody 20D8 for resisting SARS-CoV-2 epidemic mutant strain
CN113234151B (en) 2021-06-08 2022-02-15 皖南医学院第一附属医院（皖南医学院弋矶山医院） Development of CAR-NK (Carcar-natural killer) based on trimer nano antibody of SARS-CoV2 virus S protein
CN113248581A (en) 2021-06-15 2021-08-13 江西浩然生物制药有限公司 Novel corona S antigen for generating neutralizing antibody of novel corona virus and preparation method thereof

Also Published As

Publication number Publication date
MA54405A (en) 2022-01-26
DK3889177T5 (en) 2024-08-05
US11732030B2 (en) 2023-08-22
TWI785350B (en) 2022-12-01
EP4209507A1 (en) 2023-07-12
TW202308686A (en) 2023-03-01
US10975139B1 (en) 2021-04-13
PT3889177T (en) 2023-02-02
FI3889177T3 (en) 2023-03-19
CL2021000997A1 (en) 2021-09-10
MA54405B1 (en) 2023-05-31
IL282060A (en) 2021-05-31
KR20210134300A (en) 2021-11-09
CR20220552A (en) 2023-01-17
CA3115553A1 (en) 2021-03-11
EP3889177A1 (en) 2021-10-06
US20220356230A1 (en) 2022-11-10
WO2021045836A1 (en) 2021-03-11
US10954289B1 (en) 2021-03-23
US10787501B1 (en) 2020-09-29
CL2023000705A1 (en) 2023-08-25
AU2020340881A1 (en) 2021-10-21
JP2024038003A (en) 2024-03-19
CN113766928A (en) 2021-12-07
JP7116256B1 (en) 2022-08-09
PE20221893A1 (en) 2022-12-13
MY197648A (en) 2023-06-30
PH12021550793A1 (en) 2022-02-28
ES2939895T3 (en) 2023-04-27
HUE061425T2 (en) 2023-06-28
CO2021005072A2 (en) 2021-04-30
MX2021004130A (en) 2021-06-15
US20230348569A1 (en) 2023-11-02
TW202138004A (en) 2021-10-16
BR112020015534A2 (en) 2021-10-05
CA3192925A1 (en) 2021-03-11
RS64105B1 (en) 2023-04-28
JP7411029B2 (en) 2024-01-10
CA3115553C (en) 2023-04-25
JP2022536429A (en) 2022-08-17
DK3889177T3 (en) 2023-02-13
HRP20230338T1 (en) 2023-05-26
EP3889177B1 (en) 2023-01-11
JP2022160520A (en) 2022-10-19
SI3889177T1 (en) 2023-03-31
PL3889177T3 (en) 2023-05-08
LT3889177T (en) 2023-02-10

Similar Documents

Publication Publication Date Title
IL282060A (en) Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
ZA202004494B (en) Anti-tmprss2 antibodies and antigen-binding fragments
IL269593A (en) Anti-ilt4 antibodies and antigen-binding fragments
IL286690A (en) Anti-egfrviii antibodies and antigen-binding fragments thereof
IL310012A (en) Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
EP3901175A4 (en) Anti-cd73 monoclonal antibody and application thereof
EP3882268A4 (en) Anti-cd73 antibody, antigen-binding fragment thereof and application thereof
IL267898A (en) Monovalent anti-properdin antibodies and antibody fragments
IL291545A (en) Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP4242234A4 (en) Anti-lag-3 monoclonal antibody, and antigen-binding fragment and application thereof
IL277296A (en) Anti-pfrh5 antibodies and antigen-binding fragments thereof
EP4081548A4 (en) Anti-sirp? monoclonal antibodies and uses thereof
EP4245855A4 (en) Anti-tspan8-anti-cd3 bispecific antibody and anti-tspan8 antibody
IL291082A (en) Anti-vsig4 antibody or antigen binding fragment and uses thereof
TWI858423B (en) Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
IL311753A (en) Humanized anti-egfrviii antibodies and antigen-binding fragments thereof
GB201918103D0 (en) Epitopes and antibodies
EP4132952A4 (en) Monoclonal antibodies and uses thereof
GB202008095D0 (en) Antibody fragments
GB202004462D0 (en) Antibody fragments
EP4326777A4 (en) Humanized anti-sialyl-tn glycan antibodies and uses thereof
EP4159765A4 (en) Bispecific antibody or antigen-binding fragment thereof, and preparation method therefor
EP4247852A4 (en) Humanized anti-trka antibodies and uses thereof
EP3976091A4 (en) Anti-tem1 antibodies and antigen-binding portions thereof
GB202101780D0 (en) Epitopes and Antibodies