CA2286330C - Anti-vegf antibodies - Google Patents

Anti-vegf antibodies Download PDF

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Publication number
CA2286330C
CA2286330C CA002286330A CA2286330A CA2286330C CA 2286330 C CA2286330 C CA 2286330C CA 002286330 A CA002286330 A CA 002286330A CA 2286330 A CA2286330 A CA 2286330A CA 2286330 C CA2286330 C CA 2286330C
Authority
CA
Canada
Prior art keywords
seq
ser
antibody
tyr
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002286330A
Other languages
English (en)
French (fr)
Other versions
CA2286330A1 (en
Inventor
Manuel Baca
James A. Wells
Leonard G. Presta
Henry B. Lowman
Yvonne Man-Yee Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2286330(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/908,469 external-priority patent/US6884879B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2286330A1 publication Critical patent/CA2286330A1/en
Application granted granted Critical
Publication of CA2286330C publication Critical patent/CA2286330C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Air Bags (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
CA002286330A 1997-04-07 1998-04-03 Anti-vegf antibodies Expired - Lifetime CA2286330C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83350497A 1997-04-07 1997-04-07
US08/833,504 1997-04-07
US08/908,469 US6884879B1 (en) 1997-04-07 1997-08-06 Anti-VEGF antibodies
US08/908,469 1997-08-06
PCT/US1998/006604 WO1998045331A2 (en) 1997-04-07 1998-04-03 Anti-vegf antibodies

Publications (2)

Publication Number Publication Date
CA2286330A1 CA2286330A1 (en) 1998-10-15
CA2286330C true CA2286330C (en) 2008-06-10

Family

ID=27125626

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002286330A Expired - Lifetime CA2286330C (en) 1997-04-07 1998-04-03 Anti-vegf antibodies

Country Status (25)

Country Link
US (2) US7060269B1 (enExample)
EP (4) EP1325932B9 (enExample)
JP (1) JP3957765B2 (enExample)
KR (2) KR100870353B1 (enExample)
CN (1) CN100480269C (enExample)
AT (2) ATE293640T1 (enExample)
AU (1) AU743758B2 (enExample)
BR (1) BRPI9809387B8 (enExample)
CA (1) CA2286330C (enExample)
CY (3) CY2005008I2 (enExample)
DE (5) DE69829891T2 (enExample)
DK (2) DK0973804T3 (enExample)
ES (2) ES2273415T3 (enExample)
FR (2) FR05C0020I2 (enExample)
GE (1) GEP20105118B (enExample)
IL (1) IL132240A0 (enExample)
LT (1) LTPA2005005I1 (enExample)
LU (2) LU91167I2 (enExample)
NL (2) NL300193I2 (enExample)
NO (3) NO324264B1 (enExample)
NZ (1) NZ500078A (enExample)
PT (1) PT1325932E (enExample)
SI (1) SI1325932T1 (enExample)
TR (1) TR199903123T2 (enExample)
WO (1) WO1998045331A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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US10100115B2 (en) 2014-02-14 2018-10-16 Macrogenics, Inc. Methods for the treatment of vascularizing cancers
US12485172B2 (en) 2014-12-22 2025-12-02 Novartis Ag Pharmaceutical products and stable liquid compositions of IL-17 antibodies

Families Citing this family (513)

* Cited by examiner, † Cited by third party
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PT1325932E (pt) 2005-06-30
EP1325932A2 (en) 2003-07-09
SI1325932T1 (enExample) 2005-08-31
NL300278I1 (nl) 2007-06-01
DE69829891T2 (de) 2005-10-06
ES2273415T3 (es) 2007-05-01
NO2007015I1 (no) 2008-01-14
JP3957765B2 (ja) 2007-08-15
NO994869L (no) 1999-12-06
ATE293640T1 (de) 2005-05-15
HK1084402A1 (en) 2006-07-28
BRPI9809387B8 (pt) 2021-05-25
NO2007014I2 (no) 2011-02-21
EP1325932B1 (en) 2005-04-20
EP1650220B1 (en) 2007-09-05
TR199903123T2 (xx) 2000-05-22
IL132240A0 (en) 2001-03-19
EP1787999B1 (en) 2010-08-04
KR100870353B1 (ko) 2008-11-25
DK1325932T3 (da) 2005-05-30
EP0973804B1 (en) 2006-12-27
AU743758B2 (en) 2002-02-07
KR20080003453A (ko) 2008-01-07
NL300278I2 (nl) 2007-10-01
DE69829891D1 (de) 2005-05-25
NO2007015I2 (enExample) 2011-11-28
DE122007000021I1 (de) 2007-05-24
JP2001509817A (ja) 2001-07-24
ATE349470T1 (de) 2007-01-15
NZ500078A (en) 2001-10-26
FR07C0017I2 (fr) 2008-05-09
FR05C0020I1 (enExample) 2005-05-27
CY2005008I2 (el) 2017-11-14
CY2005008I1 (el) 2009-11-04
CN1259962A (zh) 2000-07-12
EP0973804A2 (en) 2000-01-26
HK1023577A1 (en) 2000-09-15
BR9809387A (pt) 2001-09-11
CY2007012I1 (el) 2009-11-04
DE122005000050I1 (de) 2005-12-29
LTPA2005005I1 (lt) 2017-11-27
FR05C0020I2 (fr) 2008-05-09
AU7100798A (en) 1998-10-30
EP1650220A3 (en) 2006-05-03
WO1998045331A3 (en) 1998-12-03
WO1998045331A2 (en) 1998-10-15
CN100480269C (zh) 2009-04-22
EP1325932A3 (en) 2003-10-29
GEP20105118B (en) 2010-11-25
KR20080003452A (ko) 2008-01-07
LU91167I2 (fr) 2005-06-20
EP1650220A2 (en) 2006-04-26
US7060269B1 (en) 2006-06-13
DE122005000026I1 (de) 2005-08-04
DE69836729D1 (de) 2007-02-08
NL300193I1 (nl) 2005-07-01
BRPI9809387B1 (pt) 2016-11-22
CY2007012I2 (el) 2009-11-04
EP1325932B9 (en) 2006-07-19
CY1106382T1 (el) 2010-07-28
NO2007014I1 (no) 2008-01-14
US20050112126A1 (en) 2005-05-26
FR07C0017I1 (fr) 2007-04-27
DK0973804T3 (da) 2007-05-07
CA2286330A1 (en) 1998-10-15
DE69836729T2 (de) 2007-12-13
LU91320I9 (enExample) 2018-12-31
NL300193I2 (nl) 2005-10-03

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