DE69836729D1 - Anti-vefg antibodies - Google Patents
Anti-vefg antibodiesInfo
- Publication number
- DE69836729D1 DE69836729D1 DE69836729T DE69836729T DE69836729D1 DE 69836729 D1 DE69836729 D1 DE 69836729D1 DE 69836729 T DE69836729 T DE 69836729T DE 69836729 T DE69836729 T DE 69836729T DE 69836729 D1 DE69836729 D1 DE 69836729D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- vegf
- vefg
- vitro
- vegf antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83350497A | 1997-04-07 | 1997-04-07 | |
US833504 | 1997-04-07 | ||
US908469 | 1997-08-06 | ||
US08/908,469 US6884879B1 (en) | 1997-04-07 | 1997-08-06 | Anti-VEGF antibodies |
PCT/US1998/006604 WO1998045331A2 (en) | 1997-04-07 | 1998-04-03 | Anti-vegf antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69836729D1 true DE69836729D1 (de) | 2007-02-08 |
DE69836729T2 DE69836729T2 (de) | 2007-12-13 |
Family
ID=27125626
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69829891T Expired - Lifetime DE69829891T2 (de) | 1997-04-07 | 1998-04-03 | Anti-VEGF Antikörper |
DE69836729T Expired - Lifetime DE69836729T2 (de) | 1997-04-07 | 1998-04-03 | Anti-vefg antibodies |
DE200512000026 Pending DE122005000026I1 (de) | 1997-04-07 | 1998-04-03 | Anti-VEGF Antik¦rper. |
DE200712000021 Pending DE122007000021I1 (de) | 1997-04-07 | 1998-04-03 | Anti-vefg Antibodies |
DE200512000050 Pending DE122005000050I1 (de) | 1997-04-07 | 2005-05-25 | Anti-Vegf Antik¦rper. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69829891T Expired - Lifetime DE69829891T2 (de) | 1997-04-07 | 1998-04-03 | Anti-VEGF Antikörper |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200512000026 Pending DE122005000026I1 (de) | 1997-04-07 | 1998-04-03 | Anti-VEGF Antik¦rper. |
DE200712000021 Pending DE122007000021I1 (de) | 1997-04-07 | 1998-04-03 | Anti-vefg Antibodies |
DE200512000050 Pending DE122005000050I1 (de) | 1997-04-07 | 2005-05-25 | Anti-Vegf Antik¦rper. |
Country Status (26)
Country | Link |
---|---|
US (2) | US7060269B1 (de) |
EP (4) | EP1787999B1 (de) |
JP (1) | JP3957765B2 (de) |
KR (2) | KR100870353B1 (de) |
CN (1) | CN100480269C (de) |
AT (2) | ATE293640T1 (de) |
AU (1) | AU743758B2 (de) |
BR (1) | BRPI9809387B8 (de) |
CA (1) | CA2286330C (de) |
CY (3) | CY2005008I2 (de) |
DE (5) | DE69829891T2 (de) |
DK (2) | DK1325932T5 (de) |
ES (2) | ES2273415T3 (de) |
FR (2) | FR05C0020I2 (de) |
GE (1) | GEP20105118B (de) |
HK (2) | HK1023577A1 (de) |
IL (1) | IL132240A0 (de) |
LT (1) | LTPA2005005I1 (de) |
LU (2) | LU91167I2 (de) |
NL (2) | NL300193I2 (de) |
NO (3) | NO324264B1 (de) |
NZ (1) | NZ500078A (de) |
PT (1) | PT1325932E (de) |
SI (1) | SI1325932T1 (de) |
TR (1) | TR199903123T2 (de) |
WO (1) | WO1998045331A2 (de) |
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- 1998-04-03 JP JP54292298A patent/JP3957765B2/ja not_active Expired - Lifetime
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