MX2022006330A - Anticuerpo biespecífico anti-pd-1 anti-vegfa, composición farmacéutica y uso del mismo. - Google Patents

Anticuerpo biespecífico anti-pd-1 anti-vegfa, composición farmacéutica y uso del mismo.

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Publication number
MX2022006330A
MX2022006330A MX2022006330A MX2022006330A MX2022006330A MX 2022006330 A MX2022006330 A MX 2022006330A MX 2022006330 A MX2022006330 A MX 2022006330A MX 2022006330 A MX2022006330 A MX 2022006330A MX 2022006330 A MX2022006330 A MX 2022006330A
Authority
MX
Mexico
Prior art keywords
vegfa
bispecific antibody
mutation
pharmaceutical composition
specifically
Prior art date
Application number
MX2022006330A
Other languages
English (en)
Inventor
Peng Zhang
Baiyong Li
Yu Xia
Zhongmin Wang
Original Assignee
Akeso Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akeso Biopharma Inc filed Critical Akeso Biopharma Inc
Publication of MX2022006330A publication Critical patent/MX2022006330A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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Abstract

Se proporciona un anticuerpo biespecífico anti-VEGFA anti-PD-1 y un uso del mismo. De una forma específica, el anticuerpo biespecífico anti-VEGFA anti-PD-1 comprende: una primera región funcional de la proteína dirigida al PD-1 y una segunda región funcional de la proteína dirigida al VEGFA. De acuerdo con un sistema de numeración de la Unión Europea, la mutación se presenta en dos posiciones de las posiciones 234 y 235 de una región constante de la cadena pesada de la inmunoglobulina contenida en el anticuerpo biespecífico, y después de la mutación, una constante de afinidad del anticuerpo biespecífico con Fc¿RI, Fc¿RIIa, Fc¿RIIIa y/o C1q disminuye en comparación con aquella anterior a la mutación. El anticuerpo biespecífico se puede enlazar de una forma específica a VEGFA y PD-1, puede aliviar de una forma específica la inmunosupresión de VEGFA y PD-1 en un organismo y puede inhibir la angiogénesis inducida por tumores, y por lo tanto tiene buenas perspectivas de aplicación.
MX2022006330A 2019-11-25 2020-11-25 Anticuerpo biespecífico anti-pd-1 anti-vegfa, composición farmacéutica y uso del mismo. MX2022006330A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911164156 2019-11-25
PCT/CN2020/131447 WO2021104302A1 (zh) 2019-11-25 2020-11-25 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途

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MX2022006330A true MX2022006330A (es) 2022-08-17

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US (1) US20230027029A1 (es)
EP (1) EP4067387A4 (es)
JP (1) JP2023504003A (es)
KR (1) KR20220104033A (es)
CN (1) CN112830972A (es)
AU (1) AU2020390967A1 (es)
BR (1) BR112022010069A2 (es)
CA (1) CA3162748A1 (es)
IL (1) IL293241A (es)
MX (1) MX2022006330A (es)
WO (1) WO2021104302A1 (es)
ZA (1) ZA202206885B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115068603A (zh) * 2021-03-12 2022-09-20 中山康方生物医药有限公司 含有抗pd-1-抗vegfa双特异性抗体的药物组合及其用途
CN115192718A (zh) * 2021-04-14 2022-10-18 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途
CN115558029B (zh) * 2021-10-22 2024-01-30 立凌生物制药(苏州)有限公司 靶向pd-1的双特异性抗体、及其制备和应用
CN114181310B (zh) 2022-02-14 2022-07-05 中山康方生物医药有限公司 抗tigit抗体、其药物组合物及用途
CN116731188A (zh) * 2022-03-02 2023-09-12 三优生物医药(上海)有限公司 抗pd-l1和vegf双特异性抗体及其应用
CN114736303A (zh) * 2022-03-17 2022-07-12 英诺湖医药(杭州)有限公司 抗pd-l1和4-1bb的双功能抗体及其医药用途
CA3208473A1 (en) 2022-06-22 2023-12-22 Akeso Biopharma, Inc. Pharmaceutical composition and use thereof
WO2024051223A1 (zh) 2022-09-09 2024-03-14 中山康方生物医药有限公司 药物组合及用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5747654A (en) 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
SI1325932T1 (es) 1997-04-07 2005-08-31 Genentech Inc
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
ES2666170T3 (es) * 2007-10-30 2018-05-03 Genentech, Inc. Purificación de anticuerpos mediante cromatografía de intercambio catiónico
CN105175545B (zh) * 2015-10-20 2019-01-25 安徽瀚海博兴生物技术有限公司 一种抗vegf-抗pd-1双功能抗体及其应用
KR102068600B1 (ko) * 2016-03-04 2020-01-21 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 Pdl-1 항체, 그 약학적 조성물 및 그 용도
CN106967172B (zh) 2016-08-23 2019-01-08 康方药业有限公司 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
CN106939050B (zh) * 2017-03-27 2019-05-10 顺昊细胞生物技术（天津）股份有限公司 抗pd1和cd19双特异性抗体及其应用
TW201902514A (zh) * 2017-06-05 2019-01-16 大陸商江蘇恆瑞醫藥股份有限公司 Ｐｄ－１抗體與ｖｅｇｆ配體或ｖｅｇｆ受體抑制劑聯合在製備治療腫瘤的藥物中的用途
CA3082036A1 (en) * 2017-12-29 2019-07-04 Ap Biosciences, Inc. Monospecific and bispecific proteins with immune checkpoint regulation for cancer therapy
CA3090878A1 (en) * 2018-02-11 2019-08-15 Beijing Hanmi Pharmaceutical Co., Ltd. Anti-pd-1/anti-vegf natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
CN110563849B (zh) * 2019-08-09 2022-09-09 安徽瀚海博兴生物技术有限公司 一种抗vegf-抗pd1双特异性抗体
CN110498857B (zh) * 2019-08-09 2022-09-09 安徽瀚海博兴生物技术有限公司 一种抗vegf-抗pd1双特异性抗体
CN110960543A (zh) * 2019-12-10 2020-04-07 安徽瀚海博兴生物技术有限公司 一种联合抗vegf-抗pd1双特异性抗体用于制备抗癌药物

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