BR112022010069A2 - Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica - Google Patents

Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica

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Publication number
BR112022010069A2
BR112022010069A2 BR112022010069A BR112022010069A BR112022010069A2 BR 112022010069 A2 BR112022010069 A2 BR 112022010069A2 BR 112022010069 A BR112022010069 A BR 112022010069A BR 112022010069 A BR112022010069 A BR 112022010069A BR 112022010069 A2 BR112022010069 A2 BR 112022010069A2
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BR
Brazil
Prior art keywords
antibody
vegfa
bispecific antibody
conjugate
kit
Prior art date
Application number
BR112022010069A
Other languages
English (en)
Inventor
Zhang Peng
Li Baiyong
Xia Yu
Wang Zhongmin
Original Assignee
Akeso Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akeso Biopharma Inc filed Critical Akeso Biopharma Inc
Publication of BR112022010069A2 publication Critical patent/BR112022010069A2/pt

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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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Abstract

ANTICORPO BIESPECÍFICO, MOLÉCULA DE ÁCIDO NUCLEICO ISOLADA, VETOR, CÉLULA HOSPEDEIRA, CONJUGADO, KIT, USO DO ANTICORPO BIESPECÍFICO E COMPOSIÇÃO. FARMACÊUTICA. São providos um anticorpo biespecífico anti-VEGFA-anti-PD-1 e o uso do mesmo. Especificamente, o anticorpo biespecífico anti-VEGFA-anti-PD-1 compreende: uma primeira região funcional de proteína direcionada a PD-1 e uma segunda região funcional de proteína direcionada a VEGFA. De acordo com um sistema de numeração EU, a mutação ocorre em duas posições das posições 234 e 235 de uma região constante de cadeia pesada da imunoglobulina contida no anticorpo biespecífico, e após a mutação, uma constante de afinidade do anticorpo biespecífico com FcYRI, FcYRIIa, FcYRIIIa, e/ou C1q está diminuído em comparação com aquele antes da mutação. O anticorpo biespecífico pode se ligar especificamente a VEGFA e PD-1, aliviar especificamente a imunossupressão de VEGFA e PD-1 em um organismo e inibir a angiogênese induzida por tumor e, portanto, tem boas perspectivas de aplicação.
BR112022010069A 2019-11-25 2020-11-25 Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica BR112022010069A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911164156 2019-11-25
PCT/CN2020/131447 WO2021104302A1 (zh) 2019-11-25 2020-11-25 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途

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BR112022010069A2 true BR112022010069A2 (pt) 2022-09-06

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US (1) US20230027029A1 (pt)
EP (1) EP4067387A4 (pt)
JP (1) JP2023504003A (pt)
KR (1) KR20220104033A (pt)
CN (1) CN112830972A (pt)
AU (1) AU2020390967A1 (pt)
BR (1) BR112022010069A2 (pt)
CA (1) CA3162748A1 (pt)
IL (1) IL293241A (pt)
MX (1) MX2022006330A (pt)
WO (1) WO2021104302A1 (pt)
ZA (1) ZA202206885B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL305805A (en) * 2021-03-12 2023-11-01 Akeso Biopharma Inc A pharmaceutical combination containing a bispecific anti-PD-1-anti-VEGFA antibody and its use
WO2022218384A1 (zh) * 2021-04-14 2022-10-20 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途
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