AR095499A1 - ANTICUERPOS MONOCLONALES CONTRA ANTITROMBINA b - Google Patents
ANTICUERPOS MONOCLONALES CONTRA ANTITROMBINA bInfo
- Publication number
- AR095499A1 AR095499A1 ARP140101104A ARP140101104A AR095499A1 AR 095499 A1 AR095499 A1 AR 095499A1 AR P140101104 A ARP140101104 A AR P140101104A AR P140101104 A ARP140101104 A AR P140101104A AR 095499 A1 AR095499 A1 AR 095499A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- amino acids
- sequence
- antibody comprises
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Abstract
Reivindicación 1: Un anticuerpo monoclonal capaz de unirse al complejo antitrombina (b)-heparina (ATbH), en el que la cadena pesada de dicho anticuerpo comprende: una secuencia CDR1 de aminoácidos 31 a 35 (AYRMG) de SEC ID Nº 2, una secuencia CDR2 de aminoácidos 50 a 66 (RIYSSGGRTRYADSVKG) de SEC ID Nº 2 y una secuencia CDR3 de aminoácidos 97 a 114 (AREKASDLSGSFSEALDY) de SEC ID Nº 2; y en el que la cadena ligera de dicho anticuerpo comprende: una secuencia CDR1 de aminoácidos 24 a 34 (QGDSLRSYYAS) de SEC ID Nº 1, una secuencia CDR2 de aminoácidos 50 a 56 (GKNNRPS) de SEC ID Nº 1 y una secuencia CDR3 de aminoácidos 89 a 99 (NSRDSSGNHLV) de SEC ID Nº 1. Reivindicación 20: Una composición farmacéutica que comprende una cantidad terapéuticamente eficaz del anticuerpo monoclonal de una cualquiera de las reivindicaciones 1 - 14 y un vehículo farmacéuticamente aceptable. Reivindicación 21: Un procedimiento para tratar una deficiencia o defecto genético o adquirido en la coagulación que comprende administrar una cantidad terapéuticamente eficaz de una composición farmacéutica de una cualquiera de las reivindicaciones 1 - 14 a un paciente. Reivindicación 29: Una molécula de ácido nucleico aislada que codifica un anticuerpo que se une a ATbH e inhibe la actividad anticoagulante, en la que el anticuerpo comprende una región variable de cadena pesada que comprende una secuencia de aminoácidos seleccionada del grupo que consiste en SEC ID Nº 2, 4, 6, 8 y 10.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784590P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR095499A1 true AR095499A1 (es) | 2015-10-21 |
Family
ID=50680168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101104A AR095499A1 (es) | 2013-03-14 | 2014-03-14 | ANTICUERPOS MONOCLONALES CONTRA ANTITROMBINA b |
Country Status (18)
Country | Link |
---|---|
US (4) | US20140271660A1 (es) |
EP (1) | EP2970500A1 (es) |
JP (1) | JP2016519081A (es) |
KR (1) | KR20150127202A (es) |
CN (1) | CN105229033B (es) |
AR (1) | AR095499A1 (es) |
AU (1) | AU2014236198A1 (es) |
BR (1) | BR112015021399A2 (es) |
CA (1) | CA2916421A1 (es) |
HK (1) | HK1215261A1 (es) |
MX (1) | MX2015012441A (es) |
PE (1) | PE20160533A1 (es) |
RU (1) | RU2015143696A (es) |
SG (1) | SG11201506886TA (es) |
TW (1) | TW201529602A (es) |
UY (1) | UY35457A (es) |
WO (1) | WO2014153195A1 (es) |
ZA (1) | ZA201507628B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2916421A1 (en) | 2013-03-14 | 2014-09-25 | Bayer Healthcare Llc | Monoclonal antibodies against antithrombin beta complexed with heparin |
US10356677B2 (en) * | 2014-05-19 | 2019-07-16 | Nokia Solutions And Networks Oy | Re-establishment procedure in dual connectivity networks |
DK3313879T3 (da) | 2015-06-24 | 2022-03-14 | Hoffmann La Roche | Anti-transferrinreceptor-antistoffer med tilpasset affinitet |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
CN114014936A (zh) | 2015-10-02 | 2022-02-08 | 豪夫迈·罗氏有限公司 | 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法 |
EP3430059A1 (en) * | 2016-03-18 | 2019-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-antithrombin single-domain antibodies and polypeptides comprising thereof |
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JPS5578253A (en) | 1978-12-11 | 1980-06-12 | Teikoku Hormone Mfg Co Ltd | Immune measurement of hito antithrombin 3 |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
BE896543A (fr) | 1983-04-22 | 1983-08-16 | Wallone Region | Ensembles d'anticorps monoclonaux deriges contre les proteines humaines impliquees dans la coagulation et la fibrinolyse du sang |
JPH0644876B2 (ja) | 1985-12-13 | 1994-06-15 | 株式会社ヤトロン | 抗トロンビン・アンチトロンビン3複合体モノクローナル抗体、及びその製造方法、並びにそれを用いるトロンビン・アンチトロンビン3複合体の免疫定量法、及びそれを用いるトロンビン・アンチトロンビン3複合体の精製方法 |
JPH0266458A (ja) | 1988-09-01 | 1990-03-06 | Takara Shuzo Co Ltd | ビトロネクチン及びビトロネクチン‐トロンビン‐アンチトロンビン3複合体の測定方法 |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
AU628960B2 (en) | 1989-04-07 | 1992-09-24 | Teijin Limited | Method of immunologically assaying human thrombin- antithrombin III complex, assay reagent and kit therefor |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
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FR2718849B1 (fr) | 1994-04-14 | 1996-06-14 | Pasteur Sanofi Diagnostics | Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention. |
US5753445A (en) | 1994-04-26 | 1998-05-19 | The Mount Sinai Medical Center Of The City University Of New York | Test for the detection of anti-heparin antibodies |
JP3841364B2 (ja) | 1994-10-18 | 2006-11-01 | 株式会社三菱化学ヤトロン | 抗ヒトビトロネクチン・トロンビン・アンチトロンビンiii 複合体モノクローナル抗体、ハイブリドーマ及び免疫学的測定方法 |
ATE403001T1 (de) | 1996-05-22 | 2008-08-15 | Viventia Biotech Inc | Antigenbindungsfragmente die spezifisch krebszellen nachweisen, nukleotide die für diese fragmente kodieren, und deren verwendung zur vorbeugung und zum nachweis von krebs |
WO1997045538A1 (en) | 1996-05-31 | 1997-12-04 | Medigene Ag | Novel synthetic protein structural templates for the generation, screening and evolution of functional molecular surfaces |
DE60037513T2 (de) | 1999-05-13 | 2009-02-05 | GTC Biotherapeutics, Inc., Framingham | Transgene hergestellte antithrombin iii und deren mutanten |
JP2001321167A (ja) | 2000-05-10 | 2001-11-20 | Cosmo Research Inst | モノクローナル抗体 |
PT2275449T (pt) | 2000-06-16 | 2016-12-27 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
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KR101529743B1 (ko) | 2007-11-29 | 2015-06-17 | 그리폴스 테라퓨틱스 인코포레이티드 | 재조합적으로 변형된 플라스민 |
ES2346618B1 (es) | 2008-08-14 | 2011-08-03 | Universidad De Murcia | Anticuerpo monoclonal anti antitrombina citrulinada humana y sus usos. |
NO330078B1 (no) | 2008-09-22 | 2011-02-14 | Optipro As | Fremgangsmåte og apparat for å overvåke slitasje i sikteduker |
WO2010047830A2 (en) | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | Agents for hcv treatment |
AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
EP3401333B1 (en) | 2010-09-09 | 2021-05-19 | Purdue Research Foundation | Anti-human folate receptor beta antibodies and methods of use |
US20140356377A1 (en) | 2011-08-25 | 2014-12-04 | Umc Utrecht Holding B.V. | Compounds for use in boosting coagulation |
EP2776603B1 (en) | 2011-11-11 | 2019-03-06 | SiO2 Medical Products, Inc. | PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS |
CA2916421A1 (en) * | 2013-03-14 | 2014-09-25 | Bayer Healthcare Llc | Monoclonal antibodies against antithrombin beta complexed with heparin |
JP6094713B1 (ja) | 2016-06-30 | 2017-03-15 | 富士ゼロックス株式会社 | 定着部材、定着装置、及び画像形成装置 |
-
2014
- 2014-03-14 CA CA2916421A patent/CA2916421A1/en not_active Abandoned
- 2014-03-14 TW TW103109449A patent/TW201529602A/zh unknown
- 2014-03-14 AU AU2014236198A patent/AU2014236198A1/en not_active Abandoned
- 2014-03-14 MX MX2015012441A patent/MX2015012441A/es unknown
- 2014-03-14 CN CN201480028085.2A patent/CN105229033B/zh not_active Expired - Fee Related
- 2014-03-14 US US14/214,267 patent/US20140271660A1/en not_active Abandoned
- 2014-03-14 KR KR1020157028131A patent/KR20150127202A/ko not_active Application Discontinuation
- 2014-03-14 WO PCT/US2014/029541 patent/WO2014153195A1/en active Application Filing
- 2014-03-14 UY UY0001035457A patent/UY35457A/es not_active Application Discontinuation
- 2014-03-14 EP EP14722465.3A patent/EP2970500A1/en not_active Withdrawn
- 2014-03-14 BR BR112015021399A patent/BR112015021399A2/pt not_active IP Right Cessation
- 2014-03-14 PE PE2015001972A patent/PE20160533A1/es not_active Application Discontinuation
- 2014-03-14 US US14/214,382 patent/US9593166B2/en not_active Expired - Fee Related
- 2014-03-14 US US14/770,222 patent/US9908942B2/en not_active Expired - Fee Related
- 2014-03-14 SG SG11201506886TA patent/SG11201506886TA/en unknown
- 2014-03-14 RU RU2015143696A patent/RU2015143696A/ru not_active Application Discontinuation
- 2014-03-14 JP JP2016503128A patent/JP2016519081A/ja active Pending
- 2014-03-14 AR ARP140101104A patent/AR095499A1/es unknown
-
2015
- 2015-10-13 ZA ZA2015/07628A patent/ZA201507628B/en unknown
-
2016
- 2016-03-17 HK HK16103100.3A patent/HK1215261A1/zh unknown
-
2018
- 2018-02-28 US US15/908,705 patent/US10144784B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2014153195A1 (en) | 2014-09-25 |
US9908942B2 (en) | 2018-03-06 |
BR112015021399A2 (pt) | 2017-07-18 |
US20160024222A1 (en) | 2016-01-28 |
TW201529602A (zh) | 2015-08-01 |
KR20150127202A (ko) | 2015-11-16 |
US10144784B2 (en) | 2018-12-04 |
AU2014236198A1 (en) | 2015-10-15 |
US20180244799A1 (en) | 2018-08-30 |
ZA201507628B (en) | 2017-11-29 |
JP2016519081A (ja) | 2016-06-30 |
MX2015012441A (es) | 2016-08-08 |
US20140271661A1 (en) | 2014-09-18 |
SG11201506886TA (en) | 2015-09-29 |
UY35457A (es) | 2014-10-31 |
RU2015143696A (ru) | 2017-04-19 |
US20140271660A1 (en) | 2014-09-18 |
CN105229033A (zh) | 2016-01-06 |
CA2916421A1 (en) | 2014-09-25 |
PE20160533A1 (es) | 2016-06-09 |
EP2970500A1 (en) | 2016-01-20 |
CN105229033B (zh) | 2019-04-23 |
US9593166B2 (en) | 2017-03-14 |
HK1215261A1 (zh) | 2016-08-19 |
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