EA202190535A1 - Бифункциональное антитело против pd-1 и против vegfa, его фармацевтическая композиция и его применение - Google Patents

Бифункциональное антитело против pd-1 и против vegfa, его фармацевтическая композиция и его применение

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Publication number
EA202190535A1
EA202190535A1 EA202190535A EA202190535A EA202190535A1 EA 202190535 A1 EA202190535 A1 EA 202190535A1 EA 202190535 A EA202190535 A EA 202190535A EA 202190535 A EA202190535 A EA 202190535A EA 202190535 A1 EA202190535 A1 EA 202190535A1
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Eurasian Patent Office
Prior art keywords
vegfa
pharmaceutical composition
bifunctional antibody
application
bifunctional
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EA202190535A
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English (en)
Inventor
Байюн Ли
Юй Ся
Чжунминь Максвэлл Ван
Пэн Чжан
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Акесо Биофарма, Инк.
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Application filed by Акесо Биофарма, Инк. filed Critical Акесо Биофарма, Инк.
Publication of EA202190535A1 publication Critical patent/EA202190535A1/ru

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Abstract

Бифункциональное антитело против VEGFA и против PD-1, его фармацевтическая композиция и его применение относятся к области терапии опухолей и молекулярной иммунологии. Конкретно, бифункциональное антитело против VEGFA и против PD-1 содержит первую белковую функциональную область, направленную на VEGFA, и вторую белковую функциональную область, направленную на PD-1. Указанное бифункциональное антитело может специфично связываться с VEGFA и PD-1, специфично уменьшать иммуносупрессивное действие VEGFA и PD-1 на организм и ингибировать опухоль-индуцированный ангиогенез и, таким образом, имеет хорошие перспективы применения.
EA202190535A 2018-08-30 2019-08-30 Бифункциональное антитело против pd-1 и против vegfa, его фармацевтическая композиция и его применение EA202190535A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811002548.4A CN109053895B (zh) 2018-08-30 2018-08-30 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
PCT/CN2019/103618 WO2020043184A1 (zh) 2018-08-30 2019-08-30 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途

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EA202190535A1 true EA202190535A1 (ru) 2021-07-20

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US (2) US20210340239A1 (ru)
EP (1) EP3882275A4 (ru)
JP (2) JP7374995B2 (ru)
KR (1) KR20210053912A (ru)
CN (1) CN109053895B (ru)
AU (1) AU2019332708A1 (ru)
BR (1) BR112021003559A2 (ru)
CA (1) CA3110749A1 (ru)
EA (1) EA202190535A1 (ru)
IL (1) IL281116A (ru)
MX (1) MX2021002312A (ru)
PH (1) PH12021550407A1 (ru)
SG (1) SG11202101985TA (ru)
WO (1) WO2020043184A1 (ru)
ZA (1) ZA202101894B (ru)

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CN106519034B (zh) * 2016-12-22 2020-09-18 鲁南制药集团股份有限公司 抗pd-1抗体及其用途
TWI771361B (zh) * 2017-01-20 2022-07-21 大陸商大有華夏生物醫藥集團有限公司 人程序性死亡受體pd-1的單株抗體及其片段
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
CN115192718A (zh) * 2021-04-14 2022-10-18 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途

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