EA202092945A1 - Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии - Google Patents

Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии

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Publication number
EA202092945A1
EA202092945A1 EA202092945A EA202092945A EA202092945A1 EA 202092945 A1 EA202092945 A1 EA 202092945A1 EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A1 EA202092945 A1 EA 202092945A1
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EA
Eurasian Patent Office
Prior art keywords
binding domains
antigen binding
cell therapy
different antigen
new platforms
Prior art date
Application number
EA202092945A
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English (en)
Inventor
Прит М. Чаудхари
Original Assignee
Юниверсити Оф Саутерн Калифорния
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Application filed by Юниверсити Оф Саутерн Калифорния filed Critical Юниверсити Оф Саутерн Калифорния
Publication of EA202092945A1 publication Critical patent/EA202092945A1/ru

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Abstract

В описании предложены различные антигенсвязывающие домены и платформы для создания обычных рецепторов химерного антигена и рецепторов химерного антигена следующего поколения для адоптивных клеточных терапий рака, инфекций, аллергических, дегенеративных и иммунных нарушений. Также представлены подходы для активации и размножения иммунных Т-клеток для адоптивной клеточной терапии рака, инфекции, аллергических, дегенеративных и иммунных нарушений.
EA202092945A 2018-06-01 2019-06-01 Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии EA202092945A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862679741P 2018-06-01 2018-06-01
PCT/US2019/035096 WO2019232503A1 (en) 2018-06-01 2019-06-01 Diverse antigen binding domains, novel platforms and other enhancements for cellular therapy

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JP7202512B2 (ja) 2017-06-05 2023-01-12 国立大学法人三重大学 Mage-a4由来ペプチドを認識する抗原結合性タンパク質
JP2021500861A (ja) * 2017-09-27 2021-01-14 ユニバーシティ オブ サザン カリフォルニア 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強
WO2020127618A1 (en) * 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted agonistic cd28 antigen binding molecules
EP3733707A1 (en) * 2019-04-30 2020-11-04 Celyad S.A. Car t-cells targeting bcma and uses thereof
EP3842461A1 (en) * 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
JP2023509766A (ja) * 2020-01-08 2023-03-09 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム Cd70陽性腫瘍を標的化するようにナチュラルキラー細胞を操作する方法
WO2021207689A2 (en) * 2020-04-10 2021-10-14 Juno Therapeutics, Inc. Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen
AR122014A1 (es) 2020-05-06 2022-08-03 Crispr Therapeutics Ag Receptor de antígenos quimérico enmascarado específico para la proteína tirosina cinasa de tipo 7 (ptk7) y células inmunitarias que expresan el mismo
WO2021231237A2 (en) * 2020-05-11 2021-11-18 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof
US20230416355A1 (en) * 2020-08-06 2023-12-28 Stelexis Therapeutics, Llc Il-8 antibodies and methods of use thereof
WO2022119923A1 (en) * 2020-12-02 2022-06-09 Cellular Biomedicine Group Hk Limited Bcma-targeted chimeric antigen receptors
WO2022170126A2 (en) * 2021-02-05 2022-08-11 Adagio Therapeutics, Inc. Compounds specific to coronavirus s protein and uses thereof
CN115491358A (zh) * 2021-06-17 2022-12-20 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
US20230203199A1 (en) * 2021-09-29 2023-06-29 Modex Therapeutics Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof
WO2023077026A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
CN114106199B (zh) * 2021-11-19 2022-07-12 广州百暨基因科技有限公司 靶向adgre2的嵌合抗原受体及其应用
WO2023170549A1 (en) * 2022-03-07 2023-09-14 Medimmune Llc Treatment methods using ctla-4 and pd-1 bispecific antibodies
WO2023175070A1 (en) * 2022-03-16 2023-09-21 Medigene Immunotherapies Gmbh Tcr constant region pairing library
WO2023175069A1 (en) * 2022-03-16 2023-09-21 Medigene Immunotherapies Gmbh Tcr constant region pairing library for pramevld tcrs
GB202208119D0 (en) * 2022-06-01 2022-07-13 Univ Oslo Hf Anti-steap1 car
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9833476B2 (en) * 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US10316101B2 (en) * 2014-04-14 2019-06-11 Cellectis BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
WO2016174852A1 (ja) * 2015-04-30 2016-11-03 株式会社デンソー 蒸発器
KR20180021137A (ko) * 2015-06-25 2018-02-28 아이셀 진 테라퓨틱스 엘엘씨 키메라 항원 수용체 (car), 조성물 및 이의 사용 방법
CN115927191A (zh) * 2015-10-23 2023-04-07 优瑞科生物技术公司 抗体/t细胞受体嵌合构建体及其用途
KR20230148844A (ko) * 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
EP3548055A4 (en) * 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND METHOD OF USING THEREOF

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