EA202092945A1 - Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии - Google Patents
Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапииInfo
- Publication number
- EA202092945A1 EA202092945A1 EA202092945A EA202092945A EA202092945A1 EA 202092945 A1 EA202092945 A1 EA 202092945A1 EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A1 EA202092945 A1 EA 202092945A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- binding domains
- antigen binding
- cell therapy
- different antigen
- new platforms
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 2
- 208000010668 atopic eczema Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000003412 degenerative effect Effects 0.000 abstract 2
- 208000026278 immune system disease Diseases 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
Classifications
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/62—DNA sequences coding for fusion proteins
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Abstract
В описании предложены различные антигенсвязывающие домены и платформы для создания обычных рецепторов химерного антигена и рецепторов химерного антигена следующего поколения для адоптивных клеточных терапий рака, инфекций, аллергических, дегенеративных и иммунных нарушений. Также представлены подходы для активации и размножения иммунных Т-клеток для адоптивной клеточной терапии рака, инфекции, аллергических, дегенеративных и иммунных нарушений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862679741P | 2018-06-01 | 2018-06-01 | |
PCT/US2019/035096 WO2019232503A1 (en) | 2018-06-01 | 2019-06-01 | Diverse antigen binding domains, novel platforms and other enhancements for cellular therapy |
Publications (1)
Publication Number | Publication Date |
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EA202092945A1 true EA202092945A1 (ru) | 2021-04-29 |
Family
ID=68697132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA202092945A EA202092945A1 (ru) | 2018-06-01 | 2019-06-01 | Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии |
Country Status (15)
Country | Link |
---|---|
US (1) | US20210137977A1 (ru) |
EP (1) | EP3802822A4 (ru) |
JP (1) | JP2021525509A (ru) |
KR (1) | KR20210057705A (ru) |
CN (1) | CN113286879A (ru) |
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Families Citing this family (23)
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JP7202512B2 (ja) | 2017-06-05 | 2023-01-12 | 国立大学法人三重大学 | Mage-a4由来ペプチドを認識する抗原結合性タンパク質 |
JP2021500861A (ja) * | 2017-09-27 | 2021-01-14 | ユニバーシティ オブ サザン カリフォルニア | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
WO2020127618A1 (en) * | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
EP3733707A1 (en) * | 2019-04-30 | 2020-11-04 | Celyad S.A. | Car t-cells targeting bcma and uses thereof |
EP3842461A1 (en) * | 2019-12-23 | 2021-06-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
JP2023509766A (ja) * | 2020-01-08 | 2023-03-09 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Cd70陽性腫瘍を標的化するようにナチュラルキラー細胞を操作する方法 |
WO2021207689A2 (en) * | 2020-04-10 | 2021-10-14 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
AR122014A1 (es) | 2020-05-06 | 2022-08-03 | Crispr Therapeutics Ag | Receptor de antígenos quimérico enmascarado específico para la proteína tirosina cinasa de tipo 7 (ptk7) y células inmunitarias que expresan el mismo |
WO2021231237A2 (en) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Antibodies for sars-cov-2 and uses thereof |
US20230416355A1 (en) * | 2020-08-06 | 2023-12-28 | Stelexis Therapeutics, Llc | Il-8 antibodies and methods of use thereof |
WO2022119923A1 (en) * | 2020-12-02 | 2022-06-09 | Cellular Biomedicine Group Hk Limited | Bcma-targeted chimeric antigen receptors |
WO2022170126A2 (en) * | 2021-02-05 | 2022-08-11 | Adagio Therapeutics, Inc. | Compounds specific to coronavirus s protein and uses thereof |
CN115491358A (zh) * | 2021-06-17 | 2022-12-20 | 复星凯特生物科技有限公司 | 一种靶向b7-h3和folr1双打靶点car t的制备及应用 |
US20230203199A1 (en) * | 2021-09-29 | 2023-06-29 | Modex Therapeutics | Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof |
WO2023077026A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing cells expressing ror1-binding protein |
CN114106199B (zh) * | 2021-11-19 | 2022-07-12 | 广州百暨基因科技有限公司 | 靶向adgre2的嵌合抗原受体及其应用 |
WO2023170549A1 (en) * | 2022-03-07 | 2023-09-14 | Medimmune Llc | Treatment methods using ctla-4 and pd-1 bispecific antibodies |
WO2023175070A1 (en) * | 2022-03-16 | 2023-09-21 | Medigene Immunotherapies Gmbh | Tcr constant region pairing library |
WO2023175069A1 (en) * | 2022-03-16 | 2023-09-21 | Medigene Immunotherapies Gmbh | Tcr constant region pairing library for pramevld tcrs |
GB202208119D0 (en) * | 2022-06-01 | 2022-07-13 | Univ Oslo Hf | Anti-steap1 car |
WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
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US9833476B2 (en) * | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
US10316101B2 (en) * | 2014-04-14 | 2019-06-11 | Cellectis | BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy |
WO2016174852A1 (ja) * | 2015-04-30 | 2016-11-03 | 株式会社デンソー | 蒸発器 |
KR20180021137A (ko) * | 2015-06-25 | 2018-02-28 | 아이셀 진 테라퓨틱스 엘엘씨 | 키메라 항원 수용체 (car), 조성물 및 이의 사용 방법 |
CN115927191A (zh) * | 2015-10-23 | 2023-04-07 | 优瑞科生物技术公司 | 抗体/t细胞受体嵌合构建体及其用途 |
KR20230148844A (ko) * | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
EP3548055A4 (en) * | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND METHOD OF USING THEREOF |
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2019
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CN113286879A (zh) | 2021-08-20 |
WO2019232503A1 (en) | 2019-12-05 |
US20210137977A1 (en) | 2021-05-13 |
IL279100A (en) | 2021-01-31 |
EP3802822A4 (en) | 2022-03-09 |
TW202018083A (zh) | 2020-05-16 |
CO2020016586A2 (es) | 2021-01-29 |
JP2021525509A (ja) | 2021-09-27 |
AU2019279084A1 (en) | 2020-12-17 |
MX2020012927A (es) | 2021-03-25 |
KR20210057705A (ko) | 2021-05-21 |
SG11202011837UA (en) | 2020-12-30 |
CA3101510A1 (en) | 2019-12-05 |
EP3802822A1 (en) | 2021-04-14 |
BR112020024246A2 (pt) | 2021-03-02 |
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