CO2020016586A2 - Diversos dominios de enlace de antígenos, nuevas plataformas y otras mejoras para terapia celular - Google Patents
Diversos dominios de enlace de antígenos, nuevas plataformas y otras mejoras para terapia celularInfo
- Publication number
- CO2020016586A2 CO2020016586A2 CONC2020/0016586A CO2020016586A CO2020016586A2 CO 2020016586 A2 CO2020016586 A2 CO 2020016586A2 CO 2020016586 A CO2020016586 A CO 2020016586A CO 2020016586 A2 CO2020016586 A2 CO 2020016586A2
- Authority
- CO
- Colombia
- Prior art keywords
- binding domains
- enhancements
- antigen binding
- cell therapy
- various antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 2
- 208000010668 atopic eczema Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000003412 degenerative effect Effects 0.000 abstract 2
- 208000026278 immune system disease Diseases 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
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Abstract
La divulgación proporciona diversos dominios y plataformas de unión a antígenos para la construcción de receptores de antígenos quiméricos convencionales y de próxima generación para terapias celulares adoptivas para el cáncer, infecciones, trastornos alérgicos, degenerativos e inmunes. También se proporcionan enfoques para la activación y expansión de células T inmunes para terapias celulares adoptivas para cáncer, infecciones, trastornos alérgicos, degenerativos e inmunes.
Applications Claiming Priority (2)
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WO2018225732A1 (ja) | 2017-06-05 | 2018-12-13 | 国立大学法人三重大学 | Mage-a4由来ペプチドを認識する抗原結合性タンパク質 |
BR112020005938A2 (pt) * | 2017-09-27 | 2020-11-17 | University Of Southern California | célula imune ou população de células imunes da mesma, célula efetora imune ou célula-tronco, célula que apresenta antígeno, polinucleotídeo recombinante, vetor, composição que compreende uma célula imune efetora ou uma célula-tronco, métodos para produzir uma célula efetora imune que expressa receptor imune de ocorrência não natural, para gerar uma população de células manipuladas por rna, para fornecer imunidade antidoença em um indivíduo, para tratar ou prevenir uma doença associada à expressão de um antígeno, e, uso |
MY198034A (en) * | 2018-12-21 | 2023-07-27 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
EP3733707A1 (en) * | 2019-04-30 | 2020-11-04 | Celyad S.A. | Car t-cells targeting bcma and uses thereof |
EP3842461A1 (en) * | 2019-12-23 | 2021-06-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
AU2021205249A1 (en) * | 2020-01-08 | 2022-07-21 | Board Of Regents, The University Of Texas System | A method of engineering natural killer cells to target CD70-positive tumors |
US20230149462A1 (en) * | 2020-04-10 | 2023-05-18 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
EP4138865A4 (en) * | 2020-04-24 | 2024-05-22 | Memorial Sloan Kettering Cancer Center | CHIMERIC ANTIGEN RECEPTORS DIRECTED TO CD19 AND USE THEREOF |
AR122014A1 (es) * | 2020-05-06 | 2022-08-03 | Crispr Therapeutics Ag | Receptor de antígenos quimérico enmascarado específico para la proteína tirosina cinasa de tipo 7 (ptk7) y células inmunitarias que expresan el mismo |
WO2021231237A2 (en) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Antibodies for sars-cov-2 and uses thereof |
US20230416355A1 (en) * | 2020-08-06 | 2023-12-28 | Stelexis Therapeutics, Llc | Il-8 antibodies and methods of use thereof |
AU2021393434A1 (en) * | 2020-12-02 | 2023-06-22 | Shanghai AbelZeta Ltd. | Bcma-targeted chimeric antigen receptors |
WO2022170126A2 (en) * | 2021-02-05 | 2022-08-11 | Adagio Therapeutics, Inc. | Compounds specific to coronavirus s protein and uses thereof |
CN115491358B (zh) * | 2021-06-17 | 2024-09-06 | 复星凯特生物科技有限公司 | 一种靶向b7-h3和folr1双打靶点car t的制备及应用 |
CA3232349A1 (en) * | 2021-09-29 | 2023-04-06 | Mark GRECI | Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof |
WO2023077026A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing cells expressing ror1-binding protein |
CN114106199B (zh) * | 2021-11-19 | 2022-07-12 | 广州百暨基因科技有限公司 | 靶向adgre2的嵌合抗原受体及其应用 |
WO2023170549A1 (en) * | 2022-03-07 | 2023-09-14 | Medimmune Llc | Treatment methods using ctla-4 and pd-1 bispecific antibodies |
WO2023175069A1 (en) * | 2022-03-16 | 2023-09-21 | Medigene Immunotherapies Gmbh | Tcr constant region pairing library for pramevld tcrs |
WO2023175070A1 (en) * | 2022-03-16 | 2023-09-21 | Medigene Immunotherapies Gmbh | Tcr constant region pairing library |
GB202208119D0 (en) * | 2022-06-01 | 2022-07-13 | Univ Oslo Hf | Anti-steap1 car |
WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
WO2024136899A1 (en) * | 2022-12-21 | 2024-06-27 | Synthorx, Inc. | Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies |
GB202301421D0 (en) * | 2023-02-01 | 2023-03-15 | Univ Oslo Hf | Switch receptor for use in adoptive cell therapy |
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US9206440B2 (en) * | 2009-01-23 | 2015-12-08 | Roger Williams Hospital | Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same |
US9833476B2 (en) * | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
CA2945620C (en) * | 2014-04-14 | 2022-12-06 | Cellectis | Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy |
WO2016014565A2 (en) * | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
WO2016174852A1 (ja) * | 2015-04-30 | 2016-11-03 | 株式会社デンソー | 蒸発器 |
EP3313872A4 (en) * | 2015-06-25 | 2019-03-20 | iCell Gene Therapeutics LLC | CHIMERIC ANTIGEN RECEPTORS (CARS) COMPOSITIONS AND METHOD FOR USE THEREOF |
IL258405B (en) * | 2015-10-23 | 2022-09-01 | Eureka Therapeutics Inc | Antibody/t-cell receptor chimeric structures and their uses |
CA3018382A1 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
JP2020500530A (ja) * | 2016-12-02 | 2020-01-16 | ユニバーシティ オブ サザン カリフォルニア | 合成免疫受容体およびその使用方法 |
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ZA202007393B (en) | 2024-05-30 |
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CA3101510A1 (en) | 2019-12-05 |
CN113286879A (zh) | 2021-08-20 |
MX2020012927A (es) | 2021-03-25 |
EP3802822A1 (en) | 2021-04-14 |
SG11202011837UA (en) | 2020-12-30 |
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