JP3957765B2 - 抗ｖｅｇｆ抗体 - Google Patents

抗ｖｅｇｆ抗体 Download PDF

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Publication number
JP3957765B2
JP3957765B2 JP54292298A JP54292298A JP3957765B2 JP 3957765 B2 JP3957765 B2 JP 3957765B2 JP 54292298 A JP54292298 A JP 54292298A JP 54292298 A JP54292298 A JP 54292298A JP 3957765 B2 JP3957765 B2 JP 3957765B2
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Prior art keywords
antibody
vegf
seq
amino acid
vegf antibody
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Expired - Lifetime
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JP54292298A
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English (en)
Japanese (ja)
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JP2001509817A (ja
Inventor
バカ，マニュエル
ウェルズ，ジェイムズ・エイ
プレスタ，レナード・ジー
ローマン，ヘンリー・ビー
チェン，イボンヌ・マン−イェー
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ジェネンテク・インコーポレイテッド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3957765(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/908,469 external-priority patent/US6884879B1/en
Application filed by ジェネンテク・インコーポレイテッド filed Critical ジェネンテク・インコーポレイテッド
Publication of JP2001509817A publication Critical patent/JP2001509817A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Air Bags (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
JP54292298A 1997-04-07 1998-04-03 抗ｖｅｇｆ抗体 Expired - Lifetime JP3957765B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83350497A 1997-04-07 1997-04-07
US08/833,504 1997-04-07
US08/908,469 US6884879B1 (en) 1997-04-07 1997-08-06 Anti-VEGF antibodies
US08/908,469 1997-08-06
PCT/US1998/006604 WO1998045331A2 (en) 1997-04-07 1998-04-03 Anti-vegf antibodies

Publications (2)

Publication Number Publication Date
JP2001509817A JP2001509817A (ja) 2001-07-24
JP3957765B2 true JP3957765B2 (ja) 2007-08-15

Family

ID=27125626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54292298A Expired - Lifetime JP3957765B2 (ja) 1997-04-07 1998-04-03 抗ｖｅｇｆ抗体

Country Status (25)

Country Link
US (2) US7060269B1 (enExample)
EP (4) EP1325932B9 (enExample)
JP (1) JP3957765B2 (enExample)
KR (2) KR100870353B1 (enExample)
CN (1) CN100480269C (enExample)
AT (2) ATE293640T1 (enExample)
AU (1) AU743758B2 (enExample)
BR (1) BRPI9809387B8 (enExample)
CA (1) CA2286330C (enExample)
CY (3) CY2005008I2 (enExample)
DE (5) DE69829891T2 (enExample)
DK (2) DK0973804T3 (enExample)
ES (2) ES2273415T3 (enExample)
FR (2) FR05C0020I2 (enExample)
GE (1) GEP20105118B (enExample)
IL (1) IL132240A0 (enExample)
LT (1) LTPA2005005I1 (enExample)
LU (2) LU91167I2 (enExample)
NL (2) NL300193I2 (enExample)
NO (3) NO324264B1 (enExample)
NZ (1) NZ500078A (enExample)
PT (1) PT1325932E (enExample)
SI (1) SI1325932T1 (enExample)
TR (1) TR199903123T2 (enExample)
WO (1) WO1998045331A2 (enExample)

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* Cited by examiner, † Cited by third party
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TR199903123T2 (xx) 2000-05-22
IL132240A0 (en) 2001-03-19
EP1787999B1 (en) 2010-08-04
KR100870353B1 (ko) 2008-11-25
DK1325932T3 (da) 2005-05-30
EP0973804B1 (en) 2006-12-27
AU743758B2 (en) 2002-02-07
KR20080003453A (ko) 2008-01-07
NL300278I2 (nl) 2007-10-01
DE69829891D1 (de) 2005-05-25
NO2007015I2 (enExample) 2011-11-28
DE122007000021I1 (de) 2007-05-24
JP2001509817A (ja) 2001-07-24
ATE349470T1 (de) 2007-01-15
NZ500078A (en) 2001-10-26
CA2286330C (en) 2008-06-10
FR07C0017I2 (fr) 2008-05-09
FR05C0020I1 (enExample) 2005-05-27
CY2005008I2 (el) 2017-11-14
CY2005008I1 (el) 2009-11-04
CN1259962A (zh) 2000-07-12
EP0973804A2 (en) 2000-01-26
HK1023577A1 (en) 2000-09-15
BR9809387A (pt) 2001-09-11
CY2007012I1 (el) 2009-11-04
DE122005000050I1 (de) 2005-12-29
LTPA2005005I1 (lt) 2017-11-27
FR05C0020I2 (fr) 2008-05-09
AU7100798A (en) 1998-10-30
EP1650220A3 (en) 2006-05-03
WO1998045331A3 (en) 1998-12-03
WO1998045331A2 (en) 1998-10-15
CN100480269C (zh) 2009-04-22
EP1325932A3 (en) 2003-10-29
GEP20105118B (en) 2010-11-25
KR20080003452A (ko) 2008-01-07
LU91167I2 (fr) 2005-06-20
EP1650220A2 (en) 2006-04-26
US7060269B1 (en) 2006-06-13
DE122005000026I1 (de) 2005-08-04
DE69836729D1 (de) 2007-02-08
NL300193I1 (nl) 2005-07-01
BRPI9809387B1 (pt) 2016-11-22
CY2007012I2 (el) 2009-11-04
EP1325932B9 (en) 2006-07-19
CY1106382T1 (el) 2010-07-28
NO2007014I1 (no) 2008-01-14
US20050112126A1 (en) 2005-05-26
FR07C0017I1 (fr) 2007-04-27
DK0973804T3 (da) 2007-05-07
CA2286330A1 (en) 1998-10-15
DE69836729T2 (de) 2007-12-13
LU91320I9 (enExample) 2018-12-31
NL300193I2 (nl) 2005-10-03

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