US20100111856A1
(en)
*
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
USRE47223E1
(en)
*
|
2005-06-20 |
2019-02-05 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
AU2008251608B2
(en)
|
2007-05-08 |
2014-03-27 |
Genentech, Inc. |
Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
|
US8865875B2
(en)
|
2007-08-22 |
2014-10-21 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
|
NZ584514A
(en)
*
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
CN102159248B
(zh)
|
2008-07-15 |
2013-09-11 |
健泰科生物技术公司 |
蒽环类衍生物缀合物、它们的制备方法以及它们作为抗肿瘤化合物的用途
|
WO2010065044A1
(en)
*
|
2008-12-05 |
2010-06-10 |
The Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services |
Blocking mesothelin peptide fragments
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
CA2752884A1
(en)
|
2009-02-27 |
2010-09-02 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
CN102666583B
(zh)
|
2009-07-15 |
2015-11-25 |
Aimm医疗股份公司 |
革兰氏阳性细菌特异性结合化合物
|
JP5767207B2
(ja)
*
|
2010-03-26 |
2015-08-19 |
協和発酵キリン株式会社 |
新規修飾部位導入抗体および抗体フラグメント
|
ES2621874T3
(es)
|
2010-03-26 |
2017-07-05 |
Memorial Sloan-Kettering Cancer Center |
Anticuerpos para MUC16 y métodos de uso de los mismos
|
BR112012026213B1
(pt)
|
2010-04-15 |
2021-12-28 |
Medimmune Limited |
Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa
|
CA2799540A1
(en)
*
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
JP5889912B2
(ja)
|
2010-11-17 |
2016-03-22 |
ジェネンテック, インコーポレイテッド |
アラニニルメイタンシノール抗体コンジュゲート
|
EP2655418B1
(en)
|
2010-12-20 |
2017-10-04 |
F. Hoffmann-La Roche AG |
Anti-mesothelin antibodies and immunoconjugates
|
RU2606016C2
(ru)
|
2011-01-14 |
2017-01-10 |
Редвуд Байосайнс, Инк. |
Меченые альдегидом полипептиды иммуноглобулина и способы их применения
|
MY183977A
(en)
|
2011-02-15 |
2021-03-17 |
Immunogen Inc |
Cytotoxic benzodiazepine derivatives
|
DK3138581T3
(en)
|
2011-03-17 |
2019-04-15 |
Univ Birmingham |
REDIRECTED IMMUNTERY
|
UY34317A
(es)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
Anticuerpo antireceptor de célula T (alfa)/ß
|
KR101877598B1
(ko)
|
2011-10-14 |
2018-07-11 |
메디뮨 리미티드 |
피롤로벤조디아제핀 및 그의 컨주게이트
|
AU2012328322A1
(en)
|
2011-10-27 |
2014-06-12 |
Genmab A/S |
Production of heterodimeric proteins
|
BR112014009925B1
(pt)
|
2011-10-28 |
2022-09-20 |
Teva Pharmaceuticals Australia Pty Ltd |
Construtores de polipeptídeos e seus usos
|
EP3539982A3
(en)
|
2011-12-23 |
2020-01-15 |
Pfizer Inc |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
JP2015505537A
(ja)
|
2012-01-20 |
2015-02-23 |
シー レーン バイオテクノロジーズ, エルエルシー |
結合分子コンジュゲート
|
EP2818480B1
(en)
*
|
2012-02-24 |
2020-08-26 |
Alteogen Inc. |
Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate comprising the modified antibody, and production method for same
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
SI2906296T1
(en)
|
2012-10-12 |
2018-06-29 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
ES2703151T3
(es)
|
2012-10-12 |
2019-03-07 |
Adc Therapeutics Sa |
Conjugados de anticuerpos de pirrolobenzodiazepinas
|
ES2660029T3
(es)
|
2012-10-12 |
2018-03-20 |
Medimmune Limited |
Conjugados de anticuerpo-pirrolobenzodiazepinas
|
CA2885305C
(en)
|
2012-10-12 |
2019-11-12 |
Spirogen Sarl |
Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
|
TR201902494T4
(tr)
|
2012-10-12 |
2019-03-21 |
Medimmune Ltd |
Pirrolobenzodiazepinler ve onların konjugatları.
|
HUE035694T2
(en)
|
2012-10-12 |
2018-05-28 |
Adc Therapeutics Sa |
Pirrolobenzodiazepine anti-CD22 antibody conjugates
|
NZ707486A
(en)
|
2012-10-12 |
2018-09-28 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine - anti-psma antibody conjugates
|
EP2906250B1
(en)
|
2012-10-12 |
2018-05-30 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-anti-psma antibody conjugates
|
PT2839860T
(pt)
|
2012-10-12 |
2019-07-29 |
Medimmune Ltd |
Pirrolobenzodiazepinas e conjugados das mesmas
|
WO2014089177A2
(en)
|
2012-12-04 |
2014-06-12 |
Massachusetts Institute Of Technology |
Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
|
EP2934602B1
(en)
|
2012-12-19 |
2019-02-27 |
Genentech, Inc. |
Methods and compositions for radiohalogen protein labeling
|
CN105246894A
(zh)
|
2012-12-21 |
2016-01-13 |
斯皮罗根有限公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
EA031585B1
(ru)
|
2012-12-21 |
2019-01-31 |
Медимьюн Лимитед |
Пирролобензодиазепины и их конъюгаты
|
CN103933575B
(zh)
|
2013-01-23 |
2017-09-29 |
上海新理念生物医药科技有限公司 |
一种三齿型连接子及其应用
|
DK2953976T3
(da)
*
|
2013-02-08 |
2021-06-21 |
Novartis Ag |
Specifikke modificeringssteder i antistoffer til fremstilling af immunkonjugater
|
US9968687B2
(en)
|
2013-02-22 |
2018-05-15 |
Abbvie Stemcentrx Llc |
Anti-DLL3 antibody drug conjugates
|
JP6494533B2
(ja)
|
2013-02-28 |
2019-04-03 |
イミュノジェン・インコーポレーテッド |
細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体
|
WO2014134486A2
(en)
|
2013-02-28 |
2014-09-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
JOP20140049B1
(ar)
*
|
2013-03-08 |
2021-08-17 |
Lilly Co Eli |
أجسام مضادة ترتبط بـ il-23
|
IL275376B2
(en)
|
2013-03-11 |
2024-01-01 |
Genzyme Corp |
Polypeptides with hyperglycosidic bonds
|
JP6444902B2
(ja)
|
2013-03-13 |
2018-12-26 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン及びその結合体
|
CN105142674B
(zh)
|
2013-03-13 |
2018-11-13 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓和其结合物
|
NZ710745A
(en)
|
2013-03-13 |
2019-03-29 |
Genentech Inc |
Pyrrolobenzodiazepines and conjugates thereof
|
JP6847388B2
(ja)
|
2013-03-15 |
2021-03-31 |
レゲネロン ファーマシューティカルス,インコーポレーテッド |
生物活性分子、そのコンジュゲート、及び治療用途
|
PL3677591T3
(pl)
|
2013-04-29 |
2023-06-26 |
Teva Pharmaceuticals Australia Pty Ltd |
Przeciwciała anty-cd38 i fuzje z interferonem alfa-2b o osłabionej aktywności
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
KR20160015286A
(ko)
|
2013-05-31 |
2016-02-12 |
제넨테크, 인크. |
항-세포벽 테이코산 항체 및 접합체
|
ES2793174T3
(es)
|
2013-05-31 |
2020-11-13 |
Genentech Inc |
Anticuerpos antiteicoicos de pared y conjugados
|
US9803002B2
(en)
|
2013-05-31 |
2017-10-31 |
Genentench, Inc. |
Anti-wall teichoic antibodies and conjugates
|
US10071170B2
(en)
|
2013-06-24 |
2018-09-11 |
Ablbio |
Antibody-drug conjugate having improved stability and use thereof
|
KR101899306B1
(ko)
|
2013-07-03 |
2018-10-04 |
서울대학교산학협력단 |
시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합
|
CN105358985B
(zh)
*
|
2013-07-09 |
2018-08-28 |
内布拉斯加大学董事会 |
靶向糖蛋白以治疗癌症的新方法
|
AU2014307080B2
(en)
|
2013-08-12 |
2018-06-07 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1H-benzo(E)indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
EP3038624A1
(en)
|
2013-08-26 |
2016-07-06 |
Regeneron Pharmaceuticals, Inc. |
Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses
|
KR20160044042A
(ko)
|
2013-08-28 |
2016-04-22 |
스템센트알엑스 인코포레이티드 |
부위-특이적 항체 접합 방법 및 조성물
|
WO2015052535A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
EP3054985B1
(en)
|
2013-10-11 |
2018-12-26 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
JP6515111B2
(ja)
|
2013-11-06 |
2019-05-22 |
アッヴィ・ステムセントルクス・エル・エル・シー |
新規の抗クローディン抗体および使用方法
|
PL3480215T3
(pl)
*
|
2013-11-19 |
2021-12-13 |
Remegen Co., Ltd. |
Przeciwciało anty-HER2 i jego koniugat
|
AU2014361856A1
(en)
|
2013-12-12 |
2016-06-30 |
Abbvie Stemcentrx Llc |
Novel anti-DPEP3 antibodies and methods of use
|
JP6895254B2
(ja)
|
2013-12-16 |
2021-06-30 |
ジェネンテック, インコーポレイテッド |
ペプチド模倣化合物及びその抗体−薬物コンジュゲート
|
CA2929565A1
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
CA2928952A1
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
KR20170008202A
(ko)
|
2014-02-21 |
2017-01-23 |
애브비 스템센트알엑스 엘엘씨 |
흑색종에 사용하기 위한 항-dll3 항체 및 약물 접합체
|
CN104672330A
(zh)
*
|
2014-03-11 |
2015-06-03 |
南京任诺药业有限公司 |
用于构建放射性同位素偶联标记的ADC药物的改造抗体IgG1-CH-N267C
|
CN104788566A
(zh)
*
|
2014-03-11 |
2015-07-22 |
南京任诺药业有限公司 |
用于构建放射性同位素偶联标记的ADC药物的改造抗体IgG1-CH-V280C
|
US10995148B2
(en)
|
2014-03-19 |
2021-05-04 |
Genzyme Corporation |
Site-specific glycoengineering of targeting moieties
|
GB201406767D0
(en)
|
2014-04-15 |
2014-05-28 |
Cancer Rec Tech Ltd |
Humanized anti-Tn-MUC1 antibodies anf their conjugates
|
JP6835591B2
(ja)
|
2014-04-25 |
2021-02-24 |
ピエール、ファーブル、メディカマン |
Igf−1r抗体および癌処置のためのアドレッシングビヒクルとしてのその使用
|
SI3134124T1
(sl)
|
2014-04-25 |
2019-06-28 |
Pierre Fabre Medicament |
Konjugat protitelesa zdravila IGF-1R in uporaba le-tega za zdravljenje raka
|
RU2685259C2
(ru)
|
2014-04-25 |
2019-04-17 |
Пьер Фабр Медикамент |
Конъюгат антитела и лекарственного средства и его применение для лечения рака
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
WO2016008112A1
(en)
*
|
2014-07-16 |
2016-01-21 |
Medshine Discovery Inc. |
Linkers and application towards adc thereof
|
SG10202102467RA
(en)
*
|
2014-07-24 |
2021-04-29 |
Genentech Inc |
Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond
|
TW201617368A
(zh)
|
2014-09-05 |
2016-05-16 |
史坦森特瑞斯公司 |
新穎抗mfi2抗體及使用方法
|
US10188746B2
(en)
|
2014-09-10 |
2019-01-29 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
US10077318B2
(en)
|
2014-09-12 |
2018-09-18 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
EP3191134B1
(en)
|
2014-09-12 |
2019-11-20 |
Genentech, Inc. |
Anthracycline disulfide intermediates, antibody-drug conjugates and methods
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
MA40575A
(fr)
|
2014-09-17 |
2016-03-24 |
Genentech Inc |
Pyrrolobenzodiazépines et conjugués à base de disulfure d'anticorps associés
|
CN107124870A
(zh)
|
2014-09-17 |
2017-09-01 |
基因泰克公司 |
包含抗her2抗体和吡咯并苯并二氮杂*的免疫缀合物
|
WO2016057769A2
(en)
|
2014-10-09 |
2016-04-14 |
Genzyme Corporation |
Glycoengineered antibody drug conjugates
|
WO2016055907A1
(en)
|
2014-10-10 |
2016-04-14 |
Pfizer Inc. |
Synergistic auristatin combinations
|
CA2965414C
(en)
|
2014-10-29 |
2024-01-09 |
Teva Pharmaceuticals Australia Pty Ltd |
Interferon .alpha.2.beta. variants
|
AU2015352545B2
(en)
|
2014-11-25 |
2020-10-15 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
WO2016090050A1
(en)
|
2014-12-03 |
2016-06-09 |
Genentech, Inc. |
Quaternary amine compounds and antibody-drug conjugates thereof
|
WO2016090040A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Genentech, Inc. |
Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof
|
JP6742314B2
(ja)
*
|
2014-12-03 |
2020-08-19 |
ジェネンテック, インコーポレイテッド |
抗黄色ブドウ球菌抗体リファマイシン複合体及びその使用
|
KR20170093943A
(ko)
*
|
2014-12-09 |
2017-08-16 |
애브비 인코포레이티드 |
낮은 세포 투과성을 갖는 bcl xl 억제 화합물 및 이를 포함하는 항체 약물 접합체
|
CN111620862A
(zh)
*
|
2014-12-09 |
2020-09-04 |
艾伯维公司 |
Bcl-xl抑制性化合物和包括其的抗体药物缀合物
|
JP6862343B2
(ja)
*
|
2014-12-19 |
2021-04-21 |
アブリンクス エン.ヴェー. |
システイン結合ナノボディダイマー
|
SG11201706292SA
(en)
*
|
2015-02-16 |
2017-09-28 |
Lonza Ag |
Cl and/or ch1 mutated antibodies for drug conjugation
|
CN107667120B
(zh)
|
2015-03-17 |
2022-03-08 |
纪念斯隆-凯特林癌症中心 |
抗muc16抗体及其应用
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
GB201506389D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
CA2991973C
(en)
|
2015-07-12 |
2021-12-07 |
Suzhou M-Conj Biotech Co., Ltd. |
Bridge linkers for conjugation of a cell-binding molecule
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
GB201514928D0
(en)
|
2015-08-21 |
2015-10-07 |
King S College London |
PDD compounds
|
MA45326A
(fr)
|
2015-10-20 |
2018-08-29 |
Genentech Inc |
Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
|
US9669106B2
(en)
|
2015-10-26 |
2017-06-06 |
Pierre Fabre Medicament |
Conjugate of monomethyl auristatin F and trastuzumab and its use for the treatment of cancer
|
AU2016344663B2
(en)
|
2015-10-26 |
2023-09-07 |
Pierre Fabre Medicament |
Composition for the treatment of IGF-1R expressing cancer
|
CA3008678A1
(en)
|
2015-12-21 |
2017-06-29 |
Bristol-Myers Squibb Company |
Variant antibodies for site-specific conjugation
|
CN108712911A
(zh)
*
|
2015-12-30 |
2018-10-26 |
科达制药股份有限公司 |
抗体及其缀合物
|
AU2017211120C1
(en)
|
2016-01-25 |
2021-10-07 |
Regeneron Pharmaceuticals, Inc. |
Maytansinoid derivatives, conjugates thereof, and methods of use
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
US10336683B2
(en)
|
2016-03-04 |
2019-07-02 |
Genentech, Inc. |
Process for the preparation of an antibody-rifamycin conjugate
|
JP6943872B2
(ja)
|
2016-03-25 |
2021-10-06 |
ジェネンテック, インコーポレイテッド |
多重全抗体及び抗体複合体化薬物定量化アッセイ
|
CN109219610A
(zh)
*
|
2016-04-04 |
2019-01-15 |
新泽西州立拉特格斯大学 |
拓扑异构酶毒物
|
CN109071634A
(zh)
|
2016-04-26 |
2018-12-21 |
R.P.谢勒技术有限责任公司 |
抗体偶联物及其制备和使用方法
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
US10918627B2
(en)
|
2016-05-11 |
2021-02-16 |
Massachusetts Institute Of Technology |
Convergent and enantioselective total synthesis of Communesin analogs
|
JP2019522633A
(ja)
|
2016-05-20 |
2019-08-15 |
ジェネンテック, インコーポレイテッド |
Protac抗体コンジュゲート及び使用方法
|
US20170370906A1
(en)
|
2016-05-27 |
2017-12-28 |
Genentech, Inc. |
Bioanalytical analysis of site-specific antibody drug conjugates
|
EP3464280B1
(en)
|
2016-06-06 |
2021-10-06 |
F. Hoffmann-La Roche AG |
Silvestrol antibody-drug conjugates and methods of use
|
WO2018009811A1
(en)
*
|
2016-07-08 |
2018-01-11 |
Genentech, Inc. |
Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment
|
WO2018014067A1
(en)
|
2016-07-19 |
2018-01-25 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-cd47 combination therapy
|
CN109963871A
(zh)
|
2016-08-05 |
2019-07-02 |
豪夫迈·罗氏有限公司 |
具有激动活性的多价及多表位抗体以及使用方法
|
IL265369B2
(en)
*
|
2016-09-23 |
2024-03-01 |
Regeneron Pharma |
Antibodies against (MUCIN 16) MUC16
|
EP3522933B1
(en)
|
2016-10-05 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Methods for preparing antibody drug conjugates
|
CN107789630A
(zh)
*
|
2016-10-08 |
2018-03-13 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体‑毒素偶联物及其制备方法
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
KR102459469B1
(ko)
|
2016-11-14 |
2022-10-26 |
항저우 디에이씨 바이오테크 씨오, 엘티디 |
결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
|
CA3045466A1
(en)
|
2016-12-01 |
2018-06-07 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
|
JP7244987B2
(ja)
*
|
2016-12-14 |
2023-03-23 |
シージェン インコーポレイテッド |
多剤抗体薬物コンジュゲート
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
RS61795B1
(sr)
|
2017-02-08 |
2021-06-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin antitela
|
UA123889C2
(uk)
|
2017-02-08 |
2021-06-16 |
Ейдісі Терапьютікс Са |
Кон'югати піролобензодіазепін-антитіло
|
BR112019015044A2
(pt)
*
|
2017-02-08 |
2020-03-10 |
Pfizer Inc. |
Processo de produção em grande escala para cisteínas de anticorpo capeadas e não capeadas e seu uso na conjugação de proteínas terapêuticas
|
WO2018192944A1
(en)
|
2017-04-18 |
2018-10-25 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
EP3612234B1
(en)
|
2017-04-20 |
2024-03-13 |
ADC Therapeutics SA |
Combination therapy with an anti-axl antibody-drug conjugate
|
US11965021B2
(en)
|
2017-04-26 |
2024-04-23 |
Eureka Therapeutics, Inc. |
Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
|
US11932650B2
(en)
|
2017-05-11 |
2024-03-19 |
Massachusetts Institute Of Technology |
Potent agelastatin derivatives as modulators for cancer invasion and metastasis
|
WO2018210824A1
(en)
*
|
2017-05-16 |
2018-11-22 |
Universite De Strasbourg |
Protein-drug conjugates and their use in the treatment of cancers
|
MX2019015042A
(es)
|
2017-06-14 |
2020-08-06 |
Adc Therapeutics Sa |
Regimen de dosificacion.
|
AU2018288029B2
(en)
*
|
2017-06-19 |
2021-12-23 |
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. |
Antibody-drug conjugate having acidic self-stabilization junction
|
CA3098491A1
(en)
*
|
2017-06-20 |
2018-12-27 |
Sichuan Baili Pharm Co. Ltd |
Screening of fixed-point coupling sites of cysteine-modified antibody-toxin conjugate (tdc)
|
US20210346513A1
(en)
*
|
2017-08-04 |
2021-11-11 |
Amgen Inc. |
Method of conjugation of cys-mabs
|
AU2018316532B2
(en)
|
2017-08-18 |
2022-11-24 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
CN107583058B
(zh)
*
|
2017-09-20 |
2020-09-18 |
厉保秋 |
一种t-2毒素-抗体缀合物及其用途
|
US11364303B2
(en)
|
2017-09-29 |
2022-06-21 |
Pfizer Inc. |
Cysteine engineered antibody drug conjugates
|
US10640508B2
(en)
|
2017-10-13 |
2020-05-05 |
Massachusetts Institute Of Technology |
Diazene directed modular synthesis of compounds with quaternary carbon centers
|
WO2019084026A1
(en)
|
2017-10-24 |
2019-05-02 |
Genentech, Inc. |
(4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE
|
WO2019084030A1
(en)
|
2017-10-24 |
2019-05-02 |
Genentech, Inc. |
(4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE
|
CA3081925A1
(en)
*
|
2017-11-18 |
2019-05-23 |
Nzola DE MAGALHAES |
Product and process for employing gc7 (n1-guanyl-1,7-diaminoheptane) based antigen binding conjugates in cancer therapy
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
WO2019183523A1
(en)
|
2018-03-23 |
2019-09-26 |
Genentech, Inc. |
Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl)
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
CN108727498B
(zh)
*
|
2018-04-24 |
2021-11-26 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体-毒素偶联物
|
CN108743966B
(zh)
*
|
2018-04-24 |
2021-10-19 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体-毒素偶联物
|
CN108714220B
(zh)
*
|
2018-04-24 |
2021-11-19 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体-毒素偶联物
|
CN108727499B
(zh)
*
|
2018-04-24 |
2021-12-31 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体-毒素偶联物
|
WO2019236577A2
(en)
|
2018-06-04 |
2019-12-12 |
Intrexon Corporation |
Muc16 specific chimeric antigen receptors and uses thereof
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
EP3849987B1
(en)
|
2018-09-11 |
2024-04-17 |
F. Hoffmann-La Roche AG |
Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer
|
CA3115136A1
(en)
|
2018-10-19 |
2020-04-23 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
CA3112977A1
(en)
|
2018-10-19 |
2020-04-23 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
WO2020123275A1
(en)
|
2018-12-10 |
2020-06-18 |
Genentech, Inc. |
Photocrosslinking peptides for site specific conjugation to fc-containing proteins
|
EP3897851A2
(en)
|
2018-12-17 |
2021-10-27 |
Revitope Limited |
Twin immune cell engager
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
US11478553B2
(en)
|
2019-02-15 |
2022-10-25 |
Wuxi Biologies Ireland Limited |
Process for preparing antibody-drug conjugates with improved homogeneity
|
JP2022524880A
(ja)
|
2019-03-15 |
2022-05-10 |
メドイミューン・リミテッド |
がんの治療における使用のための、アゼチドベンゾジアゼピン二量体及びこれを含む複合体
|
PT3946464T
(pt)
|
2019-03-29 |
2022-11-16 |
Medimmune Ltd |
Compostos e seus conjugados
|
CN111825742B
(zh)
*
|
2019-04-18 |
2024-01-30 |
陈铭 |
Ctpa作为特种偶合剂用于氨基酸离子液体的多肽固相合成
|
US11535634B2
(en)
|
2019-06-05 |
2022-12-27 |
Massachusetts Institute Of Technology |
Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
|
GB201908128D0
(en)
|
2019-06-07 |
2019-07-24 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
US20200390899A1
(en)
|
2019-06-13 |
2020-12-17 |
Bolt Biotherapeutics, Inc. |
Aminobenzazepine compounds, immunoconjugates, and uses thereof
|
IL289458A
(en)
|
2019-06-29 |
2022-07-01 |
Hangzhou Dac Biotech Co Ltd |
A cell-binding conjugated derivative of the tubolisin molecule and a method for its production
|
US20220313835A1
(en)
|
2019-09-03 |
2022-10-06 |
Bolt Biotherapeutics, Inc. |
Aminoquinoline compounds, immunoconjugates, and uses thereof
|
WO2021067242A1
(en)
|
2019-09-30 |
2021-04-08 |
Bolt Biotherapeutics, Inc. |
Amide-linked, aminobenzazepine immunoconjugates, and uses thereof
|
US11912784B2
(en)
|
2019-10-10 |
2024-02-27 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
BR112022007719A2
(pt)
|
2019-10-25 |
2022-07-12 |
Bolt Biotherapeutics Inc |
Imunoconjugados, composto ligante, composição farmacêutica, método para tratar câncer, uso de um imunoconjugado e método de preparação de um imunoconjugado
|
US20240123081A1
(en)
|
2019-10-25 |
2024-04-18 |
Medimmune, Llc |
Branched moiety for use in conjugates
|
CN110922476A
(zh)
*
|
2019-12-16 |
2020-03-27 |
蓝怡科技集团股份有限公司 |
一种生物素偶联抗体及其制备方法和应用
|
MX2022009052A
(es)
|
2020-01-22 |
2022-08-15 |
Medimmune Ltd |
Compuestos y conjugados de estos.
|
TW202140076A
(zh)
|
2020-01-22 |
2021-11-01 |
英商梅迪繆思有限公司 |
化合物及其軛合物
|
CA3176626A1
(en)
|
2020-05-08 |
2021-11-11 |
David Dornan |
Elastase-substrate, peptide linker immunoconjugates, and uses thereof
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
GB202011993D0
(en)
|
2020-07-31 |
2020-09-16 |
Adc Therapeutics Sa |
ANTI-IL 13Ra2 antibodies
|
CN116234586A
(zh)
|
2020-08-13 |
2023-06-06 |
博尔特生物治疗药物有限公司 |
吡唑并氮呯免疫缀合物及其用途
|
JP2023540526A
(ja)
|
2020-09-04 |
2023-09-25 |
ノヴァロック バイオセラピューティクス, リミテッド |
ネクチン-4抗体およびそれの使用
|
CA3193594A1
(en)
|
2020-09-11 |
2022-03-17 |
Medimmune Limited |
Therapeutic b7-h4 binding molecules
|
US20220195066A1
(en)
|
2020-12-11 |
2022-06-23 |
Bolt Biotherapeutics, Inc. |
Anti-cea immunoconjugates, and uses thereof
|
WO2022125908A1
(en)
|
2020-12-11 |
2022-06-16 |
Bolt Biotherapeutics, Inc. |
Anti-pd-l1 immunoconjugates, and uses thereof
|
CA3200320A1
(en)
|
2020-12-11 |
2022-06-16 |
Shelley Erin ACKERMAN |
Anti-her2 immunoconjugates, and uses thereof
|
WO2022125904A1
(en)
|
2020-12-11 |
2022-06-16 |
Bolt Biotherapeutics, Inc. |
Anti-her2 immunoconjugates, and uses thereof
|
CA3200051A1
(en)
|
2020-12-11 |
2022-06-16 |
Shelley Erin ACKERMAN |
Anti-cea immunoconjugates, and uses thereof
|
EP4046996A1
(en)
|
2021-02-19 |
2022-08-24 |
Universität Bielefeld |
Cryptophycin compounds and conjugates thereof
|
CN114957476A
(zh)
*
|
2021-02-23 |
2022-08-30 |
复旦大学 |
一种半胱氨酸工程化的结合人5t4的全人源纳米抗体
|
WO2022197877A1
(en)
|
2021-03-19 |
2022-09-22 |
Genentech, Inc. |
Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents
|
TW202300175A
(zh)
|
2021-03-26 |
2023-01-01 |
美商博特生物治療公司 |
2-胺基-4-羧醯胺-苯并氮呯免疫結合物及其用途
|
CN117769439A
(zh)
|
2021-03-26 |
2024-03-26 |
博尔特生物治疗药物有限公司 |
2-氨基-4-甲酰胺-苯并氮杂卓免疫缀合物及其用途
|
GB202105187D0
(en)
|
2021-04-12 |
2021-05-26 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
CA3234604A1
(en)
|
2021-10-29 |
2023-05-04 |
Shelley Erin ACKERMAN |
Tlr agonist immunoconjugates with cysteine-mutant antibodies, and uses thereof
|
CA3237211A1
(en)
|
2021-11-10 |
2023-05-19 |
Astrazeneca Ab |
Antibody molecules and conjugates
|
WO2023088966A1
(en)
|
2021-11-19 |
2023-05-25 |
Adc Therapeutics Sa |
Anti-psma conjugates
|
WO2023088963A1
(en)
|
2021-11-19 |
2023-05-25 |
Adc Therapeutics Sa |
Anti-il-13ralpha2 conjugates
|
TW202348252A
(zh)
|
2022-02-16 |
2023-12-16 |
英商梅迪繆思有限公司 |
用治療性結合分子治療癌症的組合療法
|
EP4230222A1
(en)
|
2022-02-17 |
2023-08-23 |
Oxsonics Limited |
Combination therapy with an anti-axl antibody-pbd conjugate and nanocups
|
WO2023160982A1
(en)
|
2022-02-28 |
2023-08-31 |
Adc Therapeutics Sa |
Dosage regimen
|
WO2023169896A1
(en)
|
2022-03-09 |
2023-09-14 |
Astrazeneca Ab |
BINDING MOLECULES AGAINST FRα
|
WO2023170216A1
(en)
|
2022-03-11 |
2023-09-14 |
Astrazeneca Ab |
A SCORING METHOD FOR AN ANTI-FRα ANTIBODY-DRUG CONJUGATE THERAPY
|
WO2024002938A1
(en)
|
2022-06-27 |
2024-01-04 |
Astrazeneca Ab |
Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
WO2024052685A1
(en)
|
2022-09-09 |
2024-03-14 |
MyricX Pharma Limited |
Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy
|
US20240165257A1
(en)
|
2022-11-01 |
2024-05-23 |
Heidelberg Pharma Research Gmbh |
Anti-gucy2c antibody and uses thereof
|
WO2024129756A1
(en)
*
|
2022-12-13 |
2024-06-20 |
Seagen Inc. |
Site-specific engineered cysteine antibody drug conjugates
|
WO2024127332A1
(en)
|
2022-12-14 |
2024-06-20 |
Pheon Therapeutics Ltd |
Cytotoxic compounds
|