|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
US5433081A
(en)
*
|
1993-01-22 |
1995-07-18 |
Major; Thomas O. |
Refrigerant recovery and purification method and apparatus with oil adsorbent separator
|
|
JP3484197B2
(ja)
|
1993-09-03 |
2004-01-06 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
アミン誘導化ヌクレオシドおよびオリゴヌクレオシド
|
|
US5502177A
(en)
*
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
|
DE69611102T2
(de)
*
|
1995-09-22 |
2001-06-21 |
Amersham Pharmacia Biotech Uk Ltd., Little Chalfont |
Verstärkung der mutagenese von nukleinsäuren
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US7812149B2
(en)
*
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US20040171031A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
|
US20040033973A1
(en)
*
|
2002-08-16 |
2004-02-19 |
Muthiah Manoharan |
Compounds and oligomeric compounds comprising novel nucleobases
|
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
|
WO2005121368A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Chimeric gapped oligomeric compositions
|
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
|
US6617422B1
(en)
|
1997-05-23 |
2003-09-09 |
Peter Nielsen |
Peptide nucleic acid monomers and oligomers
|
|
AU731909B2
(en)
|
1997-07-01 |
2001-04-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
|
US7572582B2
(en)
*
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6007992A
(en)
*
|
1997-11-10 |
1999-12-28 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
DE69828080T2
(de)
*
|
1997-11-07 |
2005-11-24 |
Isis Pharmaceuticals, Inc., Carlsbad |
Pyrimidinderivate als markierte bindungspartner
|
|
US6028183A
(en)
|
1997-11-07 |
2000-02-22 |
Gilead Sciences, Inc. |
Pyrimidine derivatives and oligonucleotides containing same
|
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
|
AU753270B2
(en)
*
|
1998-05-21 |
2002-10-10 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
|
EP1080103A4
(de)
*
|
1998-05-21 |
2003-07-02 |
Isis Pharmaceuticals Inc |
Zubereitungen und verfahren zur nicht-parenteralen verabreichung von oligonukleotiden
|
|
JP2002519048A
(ja)
*
|
1998-07-02 |
2002-07-02 |
ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク |
bcl−xLのオリゴヌクレオチド阻害剤
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6225293B1
(en)
|
1998-09-02 |
2001-05-01 |
Isis Pharmaceuticals, Inc. |
Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
|
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
|
US6300320B1
(en)
|
1999-01-05 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Modulation of c-jun using inhibitors of protein kinase C
|
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US6727356B1
(en)
*
|
1999-12-08 |
2004-04-27 |
Epoch Pharmaceuticals, Inc. |
Fluorescent quenching detection reagents and methods
|
|
US20040081959A9
(en)
*
|
1999-12-08 |
2004-04-29 |
Epoch Biosciences, Inc. |
Fluorescent quenching detection reagents and methods
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US20030176385A1
(en)
*
|
2000-02-15 |
2003-09-18 |
Jingfang Ju |
Antisense modulation of protein expression
|
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
|
US20060166227A1
(en)
*
|
2000-06-20 |
2006-07-27 |
Stephen Kingsmore |
Protein expression profiling
|
|
US6323009B1
(en)
*
|
2000-06-28 |
2001-11-27 |
Molecular Staging, Inc. |
Multiply-primed amplification of nucleic acid sequences
|
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
|
EP1326892A2
(de)
|
2000-10-12 |
2003-07-16 |
University of Rochester |
Zusammensetzungen die die proliferation von krebszellen hemmen
|
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
US20040121310A1
(en)
*
|
2002-12-18 |
2004-06-24 |
Ecker David J. |
Methods for rapid detection and identification of bioagents in forensic studies
|
|
US7226739B2
(en)
|
2001-03-02 |
2007-06-05 |
Isis Pharmaceuticals, Inc |
Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
|
|
US20040121309A1
(en)
*
|
2002-12-06 |
2004-06-24 |
Ecker David J. |
Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
|
|
US20040121314A1
(en)
*
|
2002-12-06 |
2004-06-24 |
Ecker David J. |
Methods for rapid detection and identification of bioagents in containers
|
|
US7666588B2
(en)
*
|
2001-03-02 |
2010-02-23 |
Ibis Biosciences, Inc. |
Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
|
|
US20030027135A1
(en)
*
|
2001-03-02 |
2003-02-06 |
Ecker David J. |
Method for rapid detection and identification of bioagents
|
|
US7718354B2
(en)
*
|
2001-03-02 |
2010-05-18 |
Ibis Biosciences, Inc. |
Methods for rapid identification of pathogens in humans and animals
|
|
AU2002257067A1
(en)
|
2001-03-14 |
2002-09-24 |
Myriad Genetics, Inc |
Tsg101-gag interaction and use thereof
|
|
US20050107595A1
(en)
*
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
JP2004537534A
(ja)
|
2001-06-20 |
2004-12-16 |
ジェネンテック・インコーポレーテッド |
腫瘍の診断及び治療のための組成物及び方法
|
|
US7803915B2
(en)
*
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
|
EP1404698A4
(de)
|
2001-06-21 |
2004-12-22 |
Isis Pharmaceuticals Inc |
Antisense-modulation von superoxiddismutase 1, expression in lösung
|
|
US7217510B2
(en)
*
|
2001-06-26 |
2007-05-15 |
Isis Pharmaceuticals, Inc. |
Methods for providing bacterial bioagent characterizing information
|
|
US8073627B2
(en)
|
2001-06-26 |
2011-12-06 |
Ibis Biosciences, Inc. |
System for indentification of pathogens
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
EP2151244A1
(de)
|
2001-09-18 |
2010-02-10 |
Genentech, Inc. |
Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
|
|
US7070933B2
(en)
*
|
2001-09-28 |
2006-07-04 |
Gen-Probe Incorporated |
Inversion probes
|
|
NZ566396A
(en)
|
2001-10-09 |
2009-07-31 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expressions
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US20030228319A1
(en)
|
2002-04-16 |
2003-12-11 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
KR100801388B1
(ko)
|
2002-01-02 |
2008-02-05 |
제넨테크, 인크. |
종양의 진단 및 치료 방법 및 이를 위한 조성물
|
|
US7553619B2
(en)
*
|
2002-02-08 |
2009-06-30 |
Qiagen Gmbh |
Detection method using dissociated rolling circle amplification
|
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
|
AU2003269809A1
(en)
*
|
2002-04-01 |
2003-12-12 |
Isis Pharmaceuticals, Inc. |
Method for rapid detection and identification of viral bioagents
|
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US20040092470A1
(en)
*
|
2002-06-18 |
2004-05-13 |
Leonard Sherry A. |
Dry powder oligonucleotide formualtion, preparation and its uses
|
|
EP1575992A4
(de)
|
2002-08-05 |
2007-02-21 |
Univ Rochester |
Chimäre proteine aus proteintransduzierender domäne/deaminase, verwandte verbindungen und deren verwendungen
|
|
EP1556325A4
(de)
*
|
2002-09-20 |
2007-09-19 |
Integrated Dna Tech Inc |
Anthrachinonquencherfarbstoffe, verfahren zu deren herstellung und verwendung
|
|
JP2006500030A
(ja)
*
|
2002-09-20 |
2006-01-05 |
イェール ユニバーシティ |
リボスイッチ、その使用方法、ならびにリボスイッチとともに用いるための組成物
|
|
AU2003278957A1
(en)
|
2002-09-26 |
2004-04-23 |
Amgen, Inc. |
Modulation of forkhead box o1a expression
|
|
JP2006515318A
(ja)
*
|
2002-10-29 |
2006-05-25 |
ファルマシア・コーポレーション |
特異的に発現する癌関連遺伝子、それによってコードされるポリペプチドおよびその使用方法
|
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
CA2504720C
(en)
|
2002-11-05 |
2013-12-24 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
AU2003295387A1
(en)
*
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
CA2505801A1
(en)
|
2002-11-13 |
2004-05-27 |
Rosanne Crooke |
Antisense modulation of apolipoprotein b expression
|
|
ES2420914T3
(es)
|
2002-11-13 |
2013-08-27 |
Genzyme Corporation |
Modulación antisentido de la expresión de la apolipoproteína B
|
|
AU2003295576B2
(en)
*
|
2002-11-15 |
2011-03-17 |
Eisai, Inc. |
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
|
|
WO2004045520A2
(en)
|
2002-11-15 |
2004-06-03 |
Musc Foundation For Research Development |
Complement receptor 2 targeted complement modulators
|
|
EP2410332A1
(de)
|
2002-11-21 |
2012-01-25 |
The University Of Utah |
Methode zur Identifizierung von purinergen Modulatoren des Geruchssystems
|
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
|
JP2006516193A
(ja)
|
2002-12-06 |
2006-06-29 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ヒトおよび動物における病原体の迅速な同定方法
|
|
US20040122857A1
(en)
*
|
2002-12-18 |
2004-06-24 |
Ecker David J. |
Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby
|
|
US20040121312A1
(en)
*
|
2002-12-18 |
2004-06-24 |
Ecker David J. |
Methods for rapid detection and identification of the absence of bioagents
|
|
US20040121315A1
(en)
*
|
2002-12-18 |
2004-06-24 |
Ecker David J. |
Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby
|
|
US9487823B2
(en)
*
|
2002-12-20 |
2016-11-08 |
Qiagen Gmbh |
Nucleic acid amplification
|
|
EP1583843B1
(de)
|
2002-12-20 |
2018-07-18 |
QIAGEN GmbH |
"single-primer" gesamtgenom-amplifikation
|
|
US6977153B2
(en)
*
|
2002-12-31 |
2005-12-20 |
Qiagen Gmbh |
Rolling circle amplification of RNA
|
|
CA2515484C
(en)
|
2003-02-11 |
2011-09-20 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
|
US8043834B2
(en)
|
2003-03-31 |
2011-10-25 |
Qiagen Gmbh |
Universal reagents for rolling circle amplification and methods of use
|
|
US20040198640A1
(en)
*
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US8046171B2
(en)
*
|
2003-04-18 |
2011-10-25 |
Ibis Biosciences, Inc. |
Methods and apparatus for genetic evaluation
|
|
US8057993B2
(en)
|
2003-04-26 |
2011-11-15 |
Ibis Biosciences, Inc. |
Methods for identification of coronaviruses
|
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
|
US8158354B2
(en)
*
|
2003-05-13 |
2012-04-17 |
Ibis Biosciences, Inc. |
Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
|
|
US7964343B2
(en)
*
|
2003-05-13 |
2011-06-21 |
Ibis Biosciences, Inc. |
Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
|
|
US7276599B2
(en)
*
|
2003-06-02 |
2007-10-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
|
BRPI0410886A
(pt)
|
2003-06-03 |
2006-07-04 |
Isis Pharmaceuticals Inc |
composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
|
|
DK3604537T3
(da)
|
2003-06-13 |
2022-02-28 |
Alnylam Europe Ag |
Dobbeltstrenget ribonukleinsyre med forøget effektivitet i en organisme
|
|
US20060241072A1
(en)
*
|
2003-06-20 |
2006-10-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds for use in gene modulation
|
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
US8969314B2
(en)
|
2003-07-31 |
2015-03-03 |
Regulus Therapeutics, Inc. |
Methods for use in modulating miR-122a
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
KR101501870B1
(ko)
|
2003-08-27 |
2015-03-12 |
옵쏘테크 코포레이션 |
안구의 혈관신생성 장애를 치료하기 위한 조합 치료법
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
US20100035239A1
(en)
*
|
2003-09-11 |
2010-02-11 |
Isis Pharmaceuticals, Inc. |
Compositions for use in identification of bacteria
|
|
US8546082B2
(en)
|
2003-09-11 |
2013-10-01 |
Ibis Biosciences, Inc. |
Methods for identification of sepsis-causing bacteria
|
|
US20080138808A1
(en)
*
|
2003-09-11 |
2008-06-12 |
Hall Thomas A |
Methods for identification of sepsis-causing bacteria
|
|
US8097416B2
(en)
|
2003-09-11 |
2012-01-17 |
Ibis Biosciences, Inc. |
Methods for identification of sepsis-causing bacteria
|
|
US20120122103A1
(en)
*
|
2003-09-11 |
2012-05-17 |
Rangarajan Sampath |
Compositions for use in identification of bacteria
|
|
US20060240412A1
(en)
*
|
2003-09-11 |
2006-10-26 |
Hall Thomas A |
Compositions for use in identification of adenoviruses
|
|
BRPI0413930A
(pt)
|
2003-09-18 |
2006-10-24 |
Isis Pharmaceuticals Inc |
composto oligomérico ou sal farmaceuticamente aceitável deste, composição farmacêutica ou veterinária, métodos para inibir a expressão de eif4e em uma célula, tecido ou órgão, para diminuir a proliferação de uma célula em que eif4e é expressado, e para prevenir ou tratar uma condição ou doença métodos para prevenir ou diminuir a angiogênese, e o crescimento de tumor em um paciente, oligonucleotìdeo de anti-sentido, composição farmacêutica ou veterinária, e, uso de um composto oligomérico ou sal farmaceuticamente aceitável deste
|
|
AU2004274021B2
(en)
*
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
|
PT1678194E
(pt)
|
2003-10-10 |
2013-09-30 |
Alchemia Oncology Pty Ltd |
Modulação da síntese e degradação de hialuronano no tratamento de doença
|
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
|
WO2005049849A2
(en)
*
|
2003-11-14 |
2005-06-02 |
Integrated Dna Technologies, Inc. |
Fluorescence quenching azo dyes, their methods of preparation and use
|
|
EP2412725A3
(de)
|
2003-11-17 |
2012-04-25 |
Genentech, Inc. |
Antikörper gegen CD79b zur Behandlung von Tumoren hämatopoetischen Ursprungs
|
|
US8163895B2
(en)
|
2003-12-05 |
2012-04-24 |
Ibis Biosciences, Inc. |
Compositions for use in identification of orthopoxviruses
|
|
JP2007520222A
(ja)
|
2004-01-20 |
2007-07-26 |
アイシス ファーマシューティカルズ インコーポレイテッド |
グルココルチコイドレセプター発現の調節
|
|
US8778900B2
(en)
*
|
2004-01-22 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP1 expression
|
|
US7468431B2
(en)
*
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
|
US20090280567A1
(en)
*
|
2004-02-06 |
2009-11-12 |
Dharmacon, Inc. |
Stabilized sirnas as transfection controls and silencing reagents
|
|
DE602005017362D1
(de)
*
|
2004-02-06 |
2009-12-10 |
Dharmacon Inc |
Stabilisierte rnas als transfektionskontrollen und silencing-reagentien
|
|
US7666592B2
(en)
|
2004-02-18 |
2010-02-23 |
Ibis Biosciences, Inc. |
Methods for concurrent identification and quantification of an unknown bioagent
|
|
US8119336B2
(en)
|
2004-03-03 |
2012-02-21 |
Ibis Biosciences, Inc. |
Compositions for use in identification of alphaviruses
|
|
US8569474B2
(en)
*
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
EP2700720A3
(de)
|
2004-03-15 |
2015-01-28 |
Isis Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Optimierung der Spaltung von RNA durch RNase H
|
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
AU2005230684B2
(en)
|
2004-04-05 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Process and reagents for oligonucleotide synthesis and purification
|
|
US20050260755A1
(en)
*
|
2004-04-06 |
2005-11-24 |
Isis Pharmaceuticals, Inc. |
Sequential delivery of oligomeric compounds
|
|
WO2006073458A2
(en)
|
2004-04-30 |
2006-07-13 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a c5-modified pyrimidine
|
|
AU2005326817B2
(en)
|
2004-05-21 |
2012-04-19 |
Benaroya Research Institute |
Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
|
|
CA2567839C
(en)
|
2004-05-24 |
2011-06-28 |
Isis Pharmaceuticals, Inc. |
Mass spectrometry with selective ion filtration by digital thresholding
|
|
US20050266411A1
(en)
*
|
2004-05-25 |
2005-12-01 |
Hofstadler Steven A |
Methods for rapid forensic analysis of mitochondrial DNA
|
|
AU2005252663B2
(en)
*
|
2004-06-03 |
2011-07-07 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
US8394947B2
(en)
*
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US7811753B2
(en)
|
2004-07-14 |
2010-10-12 |
Ibis Biosciences, Inc. |
Methods for repairing degraded DNA
|
|
US7427675B2
(en)
|
2004-08-23 |
2008-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
PL1809303T3
(pl)
*
|
2004-09-23 |
2019-11-29 |
Arc Medical Devices Inc |
Kompozycje farmaceutyczne i sposoby dotyczące hamowania zrostów włóknistych lub stanów zapalnych przy użyciu fukanów o niskiej zawartości siarczanów
|
|
US20060166234A1
(en)
*
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
|
US7935811B2
(en)
*
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
|
EP1869180B1
(de)
|
2005-03-03 |
2013-02-20 |
Ibis Biosciences, Inc. |
Zusammensetzung zur Verwendung bei der Identifikation von Polyomaviren
|
|
US8084207B2
(en)
*
|
2005-03-03 |
2011-12-27 |
Ibis Bioscience, Inc. |
Compositions for use in identification of papillomavirus
|
|
AU2006223498A1
(en)
|
2005-03-10 |
2006-09-21 |
Genentech, Inc. |
Methods and compositions for modulating vascular integrity
|
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
|
US20060223777A1
(en)
*
|
2005-03-29 |
2006-10-05 |
Dharmacon, Inc. |
Highly functional short hairpin RNA
|
|
EP1863908B1
(de)
*
|
2005-04-01 |
2010-11-17 |
Qiagen GmbH |
Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
|
|
US7476735B2
(en)
|
2005-05-20 |
2009-01-13 |
Integrated Dna Technologies, Inc. |
Compounds and methods for labeling oligonucleotides
|
|
EP2298829B1
(de)
|
2005-05-31 |
2017-09-20 |
École Polytechnique Fédérale de Lausanne (EPFL) |
Triblock-Copolymere zur zytoplasmischen Verabreichung gen-basierter Arzneimittel
|
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
WO2007014045A2
(en)
*
|
2005-07-21 |
2007-02-01 |
Isis Pharmaceuticals, Inc. |
Methods for rapid identification and quantitation of nucleic acid variants
|
|
DE602006017405D1
(de)
|
2005-08-11 |
2010-11-18 |
Synthetic Genomics Inc |
Verfahren zur in vitro-rekombination
|
|
KR20080036646A
(ko)
|
2005-08-17 |
2008-04-28 |
메덱시스 에스.에이. |
Ck19 발현 측정을 위한 조성물 및 방법
|
|
DE102005042073B4
(de)
*
|
2005-08-31 |
2010-11-11 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Faserlaser
|
|
EP1762627A1
(de)
|
2005-09-09 |
2007-03-14 |
Qiagen GmbH |
Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
|
|
US20070087987A1
(en)
|
2005-09-19 |
2007-04-19 |
Monia Brett P |
Modulation of glucagon receptor expression
|
|
US20070066557A1
(en)
|
2005-09-19 |
2007-03-22 |
Monia Brett P |
Modulation of glucocorticoid receptor expression
|
|
EP1934331A4
(de)
|
2005-10-14 |
2009-01-21 |
Musc Found For Res Dev |
Pax2 als ziel für die induktion von defb1-vermittelter tumorimmunität und krebstherapie
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
EP1941059A4
(de)
|
2005-10-28 |
2010-11-03 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur hemmung der expression des huntingtin-gens
|
|
EP1945270B1
(de)
|
2005-11-09 |
2011-05-25 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen und verfahren zur hemmung der expression von faktor v leiden mutationsgen
|
|
EP1966377A2
(de)
|
2005-11-21 |
2008-09-10 |
Isis Pharmaceuticals, Inc. |
Modulation der eif4e-bp2-expression
|
|
JP2009524411A
(ja)
*
|
2005-12-21 |
2009-07-02 |
イェール ユニバーシティー |
リボスイッチの調節に関連した方法および組成物
|
|
WO2007087113A2
(en)
|
2005-12-28 |
2007-08-02 |
The Scripps Research Institute |
Natural antisense and non-coding rna transcripts as drug targets
|
|
WO2007090073A2
(en)
|
2006-01-27 |
2007-08-09 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
ES2516815T3
(es)
*
|
2006-01-27 |
2014-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en la posición 6
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
JP5704741B2
(ja)
|
2006-03-31 |
2015-04-22 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Eg5遺伝子発現の抑制のための組成物および方法
|
|
AU2007245599B2
(en)
*
|
2006-05-03 |
2012-05-10 |
Baltic Technology Development, Ltd. |
Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
|
|
US8143230B2
(en)
*
|
2006-05-05 |
2012-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of PCSK9
|
|
DE102006020885A1
(de)
*
|
2006-05-05 |
2007-11-08 |
Qiagen Gmbh |
Einführung von Sequenzelementen in Nukleinsäuren
|
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
US7547684B2
(en)
*
|
2006-05-11 |
2009-06-16 |
Isis Pharmaceuticals, Inc. |
5′-modified bicyclic nucleic acid analogs
|
|
CN101489566B
(zh)
|
2006-05-19 |
2012-04-18 |
阿尔尼拉姆医药品有限公司 |
Aha基因的RNAi调控及其治疗性应用
|
|
WO2007137220A2
(en)
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
|
US20090209625A1
(en)
*
|
2006-05-23 |
2009-08-20 |
Sanjay Bhanot |
Modulation of chrebp expression
|
|
US20090280188A1
(en)
*
|
2006-06-23 |
2009-11-12 |
Northwestern University |
Asymmetric functionalizated nanoparticles and methods of use
|
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
|
US20100137440A1
(en)
*
|
2006-09-11 |
2010-06-03 |
Yale University |
Lysine riboswitches, structure-based compound design with lysine riboswitches, and methods and compositions for use of and with lysine riboswitches
|
|
JP5420412B2
(ja)
*
|
2006-09-14 |
2014-02-19 |
アイビス バイオサイエンシズ インコーポレイティッド |
病原体の同定のための標的全ゲノム増幅方法
|
|
US8809514B2
(en)
*
|
2006-09-22 |
2014-08-19 |
Ge Healthcare Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
US20100099858A1
(en)
*
|
2006-09-28 |
2010-04-22 |
Mirkin Chad A |
Maximizing Oligonucleotide Loading on Gold Nanoparticle
|
|
WO2008063758A2
(en)
|
2006-10-05 |
2008-05-29 |
Massachussetts Institute Of Technology |
Multifunctional encoded particles for high-throughput analysis
|
|
WO2008136852A2
(en)
|
2006-11-01 |
2008-11-13 |
University Of Rochester |
Methods and compositions related to the structure and function of apobec3g
|
|
EP2104509A4
(de)
*
|
2006-12-11 |
2010-03-24 |
Univ Utah Res Found |
Zusammensetzungen und verfahren zur behandlung von pathologischer angiogenese und gefässpermeabilität
|
|
EP2097448A4
(de)
|
2006-12-22 |
2010-07-21 |
Univ Utah Res Found |
Verfahren für den nachweis von augenerkrankungen und leiden sowie ihre behandlung
|
|
JP5512285B2
(ja)
|
2007-02-09 |
2014-06-04 |
ノースウェスタン ユニバーシティ |
細胞内標的を検出するための粒子
|
|
JP5680304B2
(ja)
*
|
2007-02-23 |
2015-03-04 |
アイビス バイオサイエンシズ インコーポレイティッド |
迅速な法医学的dna分析法
|
|
AU2008227458A1
(en)
|
2007-03-22 |
2008-09-25 |
Yale University |
Methods and compositions related to riboswitches that control alternative splicing
|
|
WO2008118809A1
(en)
*
|
2007-03-23 |
2008-10-02 |
Ibis Biosciences, Inc. |
Compositions for use in identification of mixed populations of bioagents
|
|
US7759320B2
(en)
|
2007-03-29 |
2010-07-20 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the Ebola
|
|
MX2009012647A
(es)
*
|
2007-05-29 |
2009-12-14 |
Univ Yale |
Metodos y composiciones relacionadas con ribointerruptores que controlan la separacion alternativa y proceso de arn.
|
|
MX2009012773A
(es)
|
2007-05-29 |
2009-12-16 |
Univ Yale |
Ribointerruptores y metodos y composiciones para usarse de y con ribointerruptores.
|
|
AU2008259907B2
(en)
|
2007-05-30 |
2014-12-04 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
AU2008260277C1
(en)
|
2007-05-30 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
WO2008151023A2
(en)
|
2007-06-01 |
2008-12-11 |
Ibis Biosciences, Inc. |
Methods and compositions for multiple displacement amplification of nucleic acids
|
|
US7807372B2
(en)
*
|
2007-06-04 |
2010-10-05 |
Northwestern University |
Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
EP2176280B2
(de)
*
|
2007-07-05 |
2015-06-24 |
Isis Pharmaceuticals, Inc. |
6-disubstituierte bizyklische nukleinsäureanaloga
|
|
JP5572090B2
(ja)
*
|
2007-08-15 |
2014-08-13 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
テトラヒドロピラン核酸類似体
|
|
JP2010538005A
(ja)
*
|
2007-08-28 |
2010-12-09 |
ユーエービー リサーチ ファウンデーション |
合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法
|
|
AU2008296487A1
(en)
|
2007-08-28 |
2009-03-12 |
The Uab Research Foundation |
Synthetic apolipoprotein E mimicking polypeptides and methods of use
|
|
WO2009039466A1
(en)
|
2007-09-20 |
2009-03-26 |
Vanderbilt University |
Free solution measurement of molecular interactions by backscattering interferometry
|
|
US7951785B2
(en)
*
|
2007-09-21 |
2011-05-31 |
California Institute Of Technology |
NFIA in glial fate determination, glioma therapy and astrocytoma treatment
|
|
US20110152346A1
(en)
*
|
2007-11-05 |
2011-06-23 |
Baltic Technology Development Ltd. |
Use of Oligonucleotides with Modified Bases in Hybridization of Nucleic Acids
|
|
ES2641290T3
(es)
|
2007-11-20 |
2017-11-08 |
Ionis Pharmaceuticals, Inc |
Modulación de la expresión de CD40
|
|
AU2008335202A1
(en)
|
2007-12-10 |
2009-06-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor VII gene
|
|
US7845686B2
(en)
*
|
2007-12-17 |
2010-12-07 |
S & B Technical Products, Inc. |
Restrained pipe joining system for plastic pipe
|
|
EP3100718B1
(de)
|
2008-01-02 |
2019-11-27 |
Arbutus Biopharma Corporation |
Verbesserte zusammensetzungen und verfahren zur freisetzung von nukleinsäuren
|
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
JP5697993B2
(ja)
|
2008-02-11 |
2015-04-08 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
修飾RNAiポリヌクレオチドおよびその使用
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
KR101397407B1
(ko)
|
2008-03-05 |
2014-06-19 |
알닐람 파마슈티칼스 인코포레이티드 |
Eg5 및 VEGF 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
EP2285819B1
(de)
*
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomere verbindungen, die neutral gebundene, terminal bicyclische nukleoside enthalten
|
|
EP2274423A2
(de)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
|
|
MX2010011508A
(es)
|
2008-04-18 |
2011-05-03 |
Baxter Int |
Composicion basada en microesferas para prevenir y/o revertir la nueva presentacion de diabetes autoinmune.
|
|
EP2280995A2
(de)
*
|
2008-04-29 |
2011-02-09 |
Wyeth LLC |
Verfahren zur behandlung von entzündungen
|
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
|
EP2323667A4
(de)
*
|
2008-08-07 |
2012-07-25 |
Isis Pharmaceuticals Inc |
Modulierung der transthyretin-expression durch behandlung von zns-erkrankungen
|
|
CN107083386A
(zh)
|
2008-08-25 |
2017-08-22 |
埃克斯雷德制药有限公司 |
阻止结缔组织生长因子的反义核苷酸及其用途
|
|
WO2010028054A1
(en)
|
2008-09-02 |
2010-03-11 |
Alnylam Europe Ag. |
Compositions and methods for inhibiting expression of mutant egfr gene
|
|
EP2349549B1
(de)
|
2008-09-16 |
2012-07-18 |
Ibis Biosciences, Inc. |
Mischpatronen, mischstationen und verwandte ausrüstungen, und system
|
|
US8148163B2
(en)
|
2008-09-16 |
2012-04-03 |
Ibis Biosciences, Inc. |
Sample processing units, systems, and related methods
|
|
EP2344893B1
(de)
|
2008-09-16 |
2014-10-15 |
Ibis Biosciences, Inc. |
Mikroplatten-handhabungssysteme und verfahren
|
|
JP2012502991A
(ja)
|
2008-09-22 |
2012-02-02 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
皮膚適用におけるrna干渉
|
|
US8604192B2
(en)
*
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
|
EP2356129B1
(de)
*
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituierte alpha-l-bicyclische nukleoside
|
|
AU2009296395A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Serum Amyloid A gene
|
|
AU2009303345B2
(en)
|
2008-10-09 |
2015-08-20 |
Arbutus Biopharma Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
RU2535964C2
(ru)
|
2008-10-15 |
2014-12-20 |
АйЭсАйЭс ФАРМАСЬЮТИКАЛЗ, ИНК. |
Модуляция экспрессии фактора 11
|
|
IL302142B2
(en)
|
2008-10-20 |
2024-07-01 |
Alnylam Pharmaceuticals Inc |
Compounds and methods for inhibiting transthyretin expression
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
CA2741294C
(en)
|
2008-10-24 |
2018-04-24 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
EP2365803B1
(de)
*
|
2008-11-24 |
2017-11-01 |
Northwestern University |
Polyvalente rna-nanoteilchen-zusammensetzungen
|
|
JP5645840B2
(ja)
|
2008-12-02 |
2014-12-24 |
株式会社Wave Life Sciences Japan |
リン原子修飾核酸の合成方法
|
|
JP5923306B2
(ja)
|
2008-12-04 |
2016-05-24 |
クルナ・インコーポレーテッド |
腫瘍抑制遺伝子に対する天然アンチセンス転写物の抑制による腫瘍抑制遺伝子関連疾患の治療
|
|
JP6091752B2
(ja)
|
2008-12-04 |
2017-03-08 |
クルナ・インコーポレーテッド |
Epoに対する天然アンチセンス転写物の抑制によるエリスロポエチン(epo)関連疾患の治療
|
|
WO2010065662A2
(en)
|
2008-12-04 |
2010-06-10 |
Curna, Inc. |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1
|
|
NZ593618A
(en)
|
2008-12-10 |
2013-02-22 |
Alnylam Pharmaceuticals Inc |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
|
WO2010080616A1
(en)
|
2008-12-19 |
2010-07-15 |
Abbott Laboratories |
Molecular assay for diagnosis of malaria
|
|
US20110207143A1
(en)
*
|
2008-12-19 |
2011-08-25 |
Abbott Laboratories |
Diagnostic test for mutations in codons 12-13 of human k-ras
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
WO2010081049A1
(en)
*
|
2009-01-08 |
2010-07-15 |
Northwestern University |
Inhibition of bacterial protein production by polyvalent oligonucleotide modified nanoparticle conjugates
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
KR101546673B1
(ko)
*
|
2009-01-15 |
2015-08-25 |
삼성전자주식회사 |
전자 사진용 토너 및 그의 제조방법
|
|
CA2750820A1
(en)
|
2009-01-27 |
2010-08-05 |
Qiagen Gaithersburg |
Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
|
|
WO2010088537A2
(en)
|
2009-01-29 |
2010-08-05 |
Alnylam Pharmaceuticals, Inc. |
Improved lipid formulation
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2010091308A2
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
US8158936B2
(en)
|
2009-02-12 |
2012-04-17 |
Ibis Biosciences, Inc. |
Ionization probe assemblies
|
|
EP3009150B1
(de)
|
2009-02-12 |
2019-11-13 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem brain-derived neurotrophen faktor (bdnf) mittels hemmung des natürlichen antisense-transkripts gegen bdnf
|
|
US20110319476A1
(en)
|
2009-02-12 |
2011-12-29 |
Opko Curna, Llc |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
|
US20120041051A1
(en)
|
2009-02-26 |
2012-02-16 |
Kevin Fitzgerald |
Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
|
|
CA2754749C
(en)
|
2009-03-04 |
2019-04-30 |
Opko Curna, Llc |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
|
|
CA2754043A1
(en)
|
2009-03-12 |
2010-09-16 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
EP2408919B1
(de)
|
2009-03-16 |
2017-10-18 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem nuklearfaktor (erythroid-derived)-like 2 (nrf2) mittels hemmung des natürlichen antisense-transkripts gegen nrf2
|
|
US9708604B2
(en)
|
2009-03-17 |
2017-07-18 |
Curna, Inc. |
Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
|
|
WO2010114842A1
(en)
|
2009-03-30 |
2010-10-07 |
Ibis Biosciences, Inc. |
Bioagent detection systems, devices, and methods
|
|
AU2010237001B2
(en)
|
2009-04-15 |
2016-07-07 |
Northwestern University |
Delivery of oligonucleotide-functionalized nanoparticles
|
|
EP3248618A1
(de)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Angeborene immununterdrückung mit ermöglichung der wiederholten verabreichung von langen rna-molekülen
|
|
CN102639151B
(zh)
|
2009-05-01 |
2017-03-22 |
库尔纳公司 |
通过针对hbf/hbg的天然反义转录物的抑制治疗血红蛋白(hbf/hbg)相关疾病
|
|
EP3504967A1
(de)
|
2009-05-05 |
2019-07-03 |
Arbutus Biopharma Corporation |
Verfahren zur abgabe von oligonukleotiden an immunzellen
|
|
WO2010129709A1
(en)
|
2009-05-05 |
2010-11-11 |
Alnylam Pharmaceuticals, Inc. |
Lipid compositions
|
|
EP2427553A4
(de)
|
2009-05-06 |
2012-11-07 |
Opko Curna Llc |
Behandlung von lipidtransport- und stoffwechselgenbedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein lipidtransport- und stoffwechselgen
|
|
WO2010129746A2
(en)
|
2009-05-06 |
2010-11-11 |
Curna, Inc. |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
|
US20120107331A1
(en)
|
2009-05-15 |
2012-05-03 |
Yale University |
Gemm riboswitches, structure-based compound design with gemm riboswitches, and methods and compositions for use of and with gemm riboswitches
|
|
CA2762369C
(en)
|
2009-05-18 |
2021-12-28 |
Joseph Collard |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
|
CN102549158B
(zh)
|
2009-05-22 |
2017-09-26 |
库尔纳公司 |
通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病
|
|
CA2764683A1
(en)
|
2009-05-28 |
2010-12-02 |
Joseph Collard |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
|
SMT201800499T1
(it)
|
2009-06-10 |
2018-11-09 |
Arbutus Biopharma Corp |
Formulazione lipidica migliorata
|
|
EP2443237B1
(de)
|
2009-06-16 |
2017-02-22 |
CuRNA, Inc. |
Behandlung von krankheiten im zusammenhang mit dem kollagengen durch hemmung des natürlichen antisense-transkripts zu einem kollagengens
|
|
KR101702689B1
(ko)
|
2009-06-16 |
2017-02-06 |
큐알엔에이, 인크. |
Pon1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(pon1) 관련된 질환의 치료
|
|
EP2446036B1
(de)
|
2009-06-24 |
2017-03-01 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit tumornekrose faktor-rezeptor 2 (tnfr2) mittels hemmung des natürlichen antisense-transkripts gegen tnfr2
|
|
CA2765815A1
(en)
|
2009-06-26 |
2010-12-29 |
Opko Curna, Llc |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
|
EP2451461A4
(de)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
|
|
US8950604B2
(en)
*
|
2009-07-17 |
2015-02-10 |
Ibis Biosciences, Inc. |
Lift and mount apparatus
|
|
WO2011008972A1
(en)
|
2009-07-17 |
2011-01-20 |
Ibis Biosciences, Inc. |
Systems for bioagent identification
|
|
WO2011014811A1
(en)
|
2009-07-31 |
2011-02-03 |
Ibis Biosciences, Inc. |
Capture primers and capture sequence linked solid supports for molecular diagnostic tests
|
|
CN102762731B
(zh)
|
2009-08-05 |
2018-06-22 |
库尔纳公司 |
通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
|
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
|
US9029338B2
(en)
|
2009-08-14 |
2015-05-12 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
|
US20120157324A1
(en)
|
2009-08-17 |
2012-06-21 |
Yale University |
Methylation biomarkers and methods of use
|
|
WO2011031482A2
(en)
|
2009-08-25 |
2011-03-17 |
Curna, Inc. |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
|
CA2772715C
(en)
|
2009-09-02 |
2019-03-26 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
WO2011041695A1
(en)
*
|
2009-10-02 |
2011-04-07 |
Ibis Biosciences, Inc. |
Determination of methylation status of polynucleotides
|
|
US9890408B2
(en)
*
|
2009-10-15 |
2018-02-13 |
Ibis Biosciences, Inc. |
Multiple displacement amplification
|
|
KR101857694B1
(ko)
*
|
2009-10-16 |
2018-06-19 |
멜린타 테라퓨틱스, 인크. |
항미생물성 화합물 및 이의 제조 방법 및 사용 방법
|
|
MX2012004341A
(es)
|
2009-10-16 |
2012-10-05 |
Rib X Pharmaceuticals Inc |
Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
|
|
WO2011047323A2
(en)
|
2009-10-16 |
2011-04-21 |
Rib-X Pharmaceuticals, Inc. |
Antimicrobial compounds and methods of making and using the same
|
|
MX2012004617A
(es)
|
2009-10-22 |
2012-05-08 |
Genentech Inc |
Metodos y composiciones para modular activacion de hepsina de proteina que estimula macrofago.
|
|
WO2011056687A2
(en)
|
2009-10-27 |
2011-05-12 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
|
DK2494075T3
(en)
|
2009-10-30 |
2018-07-23 |
Univ Northwestern |
TABLE-MANAGED NANOCONJUGATES
|
|
KR20120102674A
(ko)
|
2009-11-03 |
2012-09-18 |
유니버시티 오브 버지니아 페이턴트 파운데이션 |
중합체 분석물을 검출하는 다용도의 가시적인 방법
|
|
EP2504450B1
(de)
|
2009-11-23 |
2016-07-06 |
Swift Biosciences, Inc. |
Vorrichtung zur erweiterung von einsträngigen zielmolekülen
|
|
AU2010324686B2
(en)
|
2009-11-30 |
2016-05-19 |
Genentech, Inc. |
Antibodies for treating and diagnosing tumors expressing SLC34A2 (TAT211 = SEQID2 )
|
|
EP2513310B1
(de)
|
2009-12-16 |
2017-11-01 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem membranengebundenen transkriptionsfaktor-peptidase-ort 1 (mbtps1) mittels hemmung des natürlichen antisense-transkripts gegen mbtps1
|
|
ES2661387T3
(es)
|
2009-12-23 |
2018-03-28 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor de crecimiento de hepatocitos (hgf) mediante inhibición del transcrito antisentido natural a hgf
|
|
EP2515947B1
(de)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Behandlung von durch das uncoupling protein 2 (ucp2) bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts für ucp2
|
|
JP5982288B2
(ja)
|
2009-12-29 |
2016-08-31 |
カッパーアールエヌエー,インコーポレイテッド |
腫瘍タンパク質63(p63)に対する天然アンチセンス転写物の阻害による腫瘍タンパク質63関連疾患の治療
|
|
EP2519633B1
(de)
|
2009-12-29 |
2017-10-25 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem nuclear-respirator-faktor 1 (nrf1) mittels hemmung des natürlichen antisense-transkripts gegen nrf1
|
|
JP5886757B2
(ja)
|
2010-01-04 |
2016-03-16 |
カッパーアールエヌエー,インコーポレイテッド |
インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療
|
|
KR101853509B1
(ko)
|
2010-01-06 |
2018-04-30 |
큐알엔에이, 인크. |
췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
|
|
DK2524039T3
(en)
|
2010-01-11 |
2018-03-12 |
Curna Inc |
TREATMENT OF GENDER HORMON-BINDING GLOBULIN (SHBG) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS TO SHBG
|
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US20120321647A1
(en)
|
2010-01-12 |
2012-12-20 |
Yale University |
Structured rna motifs and compounds and methods for their use
|
|
RU2611192C2
(ru)
|
2010-01-25 |
2017-02-21 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С РНКазой Н1, ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К РНКазе Н1
|
|
CA2824843A1
(en)
|
2010-02-04 |
2011-08-11 |
Ico Therapeutics Inc. |
Dosing regimens for treating and preventing ocular disorders using c-raf antisense
|
|
EP2539452B1
(de)
|
2010-02-22 |
2016-07-27 |
CuRNA, Inc. |
Behandlung von durch pyrrolin-5-carboxylat-reduktase 1 (pycr1) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für pycr1
|
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
|
PE20130214A1
(es)
|
2010-02-23 |
2013-03-11 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores
|
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
|
WO2011112516A1
(en)
|
2010-03-08 |
2011-09-15 |
Ico Therapeutics Inc. |
Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
|
|
WO2011112732A2
(en)
|
2010-03-12 |
2011-09-15 |
The Brigham And Women's Hospital, Inc. |
Methods of treating vascular inflammatory disorders
|
|
US20130101512A1
(en)
|
2010-03-12 |
2013-04-25 |
Chad A. Mirkin |
Crosslinked polynucleotide structure
|
|
WO2011115817A1
(en)
|
2010-03-16 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
Methods of preparing 2'-o-substituted purine nucleosides
|
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3560503B1
(de)
|
2010-03-24 |
2021-11-17 |
Phio Pharmaceuticals Corp. |
Rna-interferenz bei dermalen und fibrotischen erkrankungen
|
|
CN103200945B
(zh)
|
2010-03-24 |
2016-07-06 |
雷克西制药公司 |
眼部症候中的rna干扰
|
|
US9080171B2
(en)
|
2010-03-24 |
2015-07-14 |
RXi Parmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
US9506057B2
(en)
|
2010-03-26 |
2016-11-29 |
Integrated Dna Technologies, Inc. |
Modifications for antisense compounds
|
|
CA2794485C
(en)
*
|
2010-03-26 |
2018-05-22 |
Integrated Dna Technologies, Inc. |
Methods for enhancing nucleic acid hybridization
|
|
US8889350B2
(en)
|
2010-03-26 |
2014-11-18 |
Swift Biosciences, Inc. |
Methods and compositions for isolating polynucleotides
|
|
WO2011123468A1
(en)
|
2010-03-29 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Sirna therapy for transthyretin (ttr) related ocular amyloidosis
|
|
JP2013523162A
(ja)
|
2010-04-06 |
2013-06-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Cd274/pd−l1遺伝子の発現を阻害するための組成物および方法
|
|
TWI644675B
(zh)
|
2010-04-09 |
2018-12-21 |
可娜公司 |
藉由抑制纖維母細胞生長因子21(fgf21)之天然反義轉錄物以治療fgf21相關疾病
|
|
US20110269194A1
(en)
|
2010-04-20 |
2011-11-03 |
Swift Biosciences, Inc. |
Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
|
|
WO2011133876A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
US20130260460A1
(en)
|
2010-04-22 |
2013-10-03 |
Isis Pharmaceuticals Inc |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
|
EP2606057B1
(de)
|
2010-04-28 |
2016-06-15 |
Ionis Pharmaceuticals, Inc. |
Modifizierte 5' diphosphat-nukleoside und daraus hergestellte oligomere verbindungen
|
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
|
EP2625186B1
(de)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
|
LT2563920T
(lt)
|
2010-04-29 |
2017-05-25 |
Ionis Pharmaceuticals, Inc. |
Transtiretino raiškos moduliavimas
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
KR101936011B1
(ko)
|
2010-05-03 |
2019-01-07 |
큐알엔에이, 인크. |
시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
|
|
PE20130460A1
(es)
|
2010-05-03 |
2013-04-26 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores
|
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
|
US8628914B2
(en)
|
2010-05-26 |
2014-01-14 |
Qiagen Gaithersburg, Inc. |
Quantitative helicase assay
|
|
WO2011150226A1
(en)
|
2010-05-26 |
2011-12-01 |
Landers James P |
Method for detecting nucleic acids based on aggregate formation
|
|
KR101857090B1
(ko)
|
2010-05-26 |
2018-06-26 |
큐알엔에이, 인크. |
무조(無調)의 동소체 1 (atoh1)에 대한 자연 안티센스 전사체의 저해에 의한 atoh1 관련된 질환의 치료
|
|
US9944671B2
(en)
|
2010-06-02 |
2018-04-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
EP2576839B1
(de)
|
2010-06-07 |
2017-05-10 |
Firefly Bioworks, Inc. |
Nukleinsäurenachweis und -quantifizierung durch posthybridisierungs-kennzeichnung und universelle kodierung
|
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156713A1
(en)
|
2010-06-11 |
2011-12-15 |
Vanderbilt University |
Multiplexed interferometric detection system and method
|
|
WO2011159836A2
(en)
|
2010-06-15 |
2011-12-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
|
WO2011163466A1
(en)
|
2010-06-23 |
2011-12-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Regulation of skin pigmentation by neuregulin-1 (nrg-1)
|
|
CA2805318A1
(en)
|
2010-07-14 |
2012-01-19 |
Curna, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
|
JP5981428B2
(ja)
|
2010-07-19 |
2016-08-31 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
筋緊張性ジストロフィー・プロテインキナーゼ(dmpk)発現の調整
|
|
WO2012021554A1
(en)
|
2010-08-09 |
2012-02-16 |
Yale University |
Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use
|
|
CA2809457C
(en)
|
2010-09-07 |
2019-07-30 |
Integrated Dna Technologies, Inc. |
Modifications for antisense compounds
|
|
US10428019B2
(en)
|
2010-09-24 |
2019-10-01 |
Wave Life Sciences Ltd. |
Chiral auxiliaries
|
|
AU2011312205B2
(en)
|
2010-10-05 |
2015-08-13 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
|
WO2012048113A2
(en)
|
2010-10-07 |
2012-04-12 |
The General Hospital Corporation |
Biomarkers of cancer
|
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
|
CN103201387B
(zh)
|
2010-10-27 |
2018-02-02 |
库尔纳公司 |
通过抑制干扰素相关发育调节因子1(ifrd1)的天然反义转录物而治疗ifrd1相关疾病
|
|
TW201307347A
(zh)
|
2010-11-01 |
2013-02-16 |
Arqule Inc |
經取代苯並-咪唑並-吡啶並-二氮呯化合物
|
|
CN110123830A
(zh)
|
2010-11-09 |
2019-08-16 |
阿尔尼拉姆医药品有限公司 |
用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
|
|
EP3260540A1
(de)
|
2010-11-12 |
2017-12-27 |
The General Hospital Corporation |
Polycombassoziierte nichtcodierende rnas
|
|
AU2011329777B2
(en)
|
2010-11-17 |
2016-06-09 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
KR102010598B1
(ko)
|
2010-11-23 |
2019-08-13 |
큐알엔에이, 인크. |
Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
|
|
US9150926B2
(en)
|
2010-12-06 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Diagnosis and treatment of adrenocortical tumors using human microRNA-483
|
|
EP2649182A4
(de)
|
2010-12-10 |
2015-05-06 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur erhöhung einer erythropoietin (epo)-herstellung
|
|
US9127275B2
(en)
|
2010-12-10 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
|
WO2012097261A2
(en)
|
2011-01-14 |
2012-07-19 |
The General Hospital Corporation |
Methods targeting mir-128 for regulating cholesterol/lipid metabolism
|
|
US9173894B2
(en)
|
2011-02-02 |
2015-11-03 |
Excaliard Pharamaceuticals, Inc. |
Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
|
|
WO2012106509A1
(en)
|
2011-02-02 |
2012-08-09 |
The Trustees Of Princeton University |
Sirtuin modulators as virus production modulators
|
|
ES2818586T3
(es)
|
2011-02-07 |
2021-04-13 |
Governing Council Univ Toronto |
Biosondas y métodos de uso de las mismas
|
|
EP3467109A1
(de)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit bicyclischen nukleotiden und verwendungen davon
|
|
US9562853B2
(en)
|
2011-02-22 |
2017-02-07 |
Vanderbilt University |
Nonaqueous backscattering interferometric methods
|
|
US9175290B2
(en)
|
2011-03-29 |
2015-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of TMPRSS6 gene
|
|
JP2014511694A
(ja)
|
2011-04-03 |
2014-05-19 |
ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル |
修飾型rna(mod−rna)を使用する効率的なインビボタンパク質発現
|
|
US20140186844A1
(en)
|
2011-04-26 |
2014-07-03 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
|
WO2012151289A2
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system to detect aggregate formation on a substrate
|
|
US9353371B2
(en)
|
2011-05-02 |
2016-05-31 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
WO2012151268A1
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system for high throughput optical and label free detection of analytes
|
|
RU2620980C2
(ru)
|
2011-06-09 |
2017-05-30 |
Курна, Инк. |
Лечение заболеваний, связанных с фратаксином (fxn), путем ингибирования природного антисмыслового транскрипта fxn
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9315813B2
(en)
|
2011-06-21 |
2016-04-19 |
Alnylam Pharmaceuticals, Inc |
Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
|
|
EP3388068A1
(de)
|
2011-06-21 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzung und verfahren zur hemmung der expression von protein-c (proc)-genen
|
|
EP4092120A1
(de)
|
2011-06-21 |
2022-11-23 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like-3 (anglptl3)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
US20140235693A1
(en)
|
2011-06-23 |
2014-08-21 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
|
US9222093B2
(en)
|
2011-06-30 |
2015-12-29 |
The University Of Hong Kong |
Two-way, portable riboswitch mediated gene expression control device
|
|
WO2013012758A1
(en)
|
2011-07-19 |
2013-01-24 |
Ontorii, Inc. |
Methods for the synthesis of functionalized nucleic acids
|
|
WO2013019857A2
(en)
|
2011-08-01 |
2013-02-07 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
|
EP2742136B1
(de)
|
2011-08-11 |
2017-09-27 |
Ionis Pharmaceuticals, Inc. |
Gapmerverbindungen mit 5'-modifizierten desoxyribonukleotiden im gap und verwendungen davon
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
EP3453761A1
(de)
|
2011-08-29 |
2019-03-13 |
Ionis Pharmaceuticals, Inc. |
Oligomer-konjugat-komplexe und deren verwendung
|
|
EP3533873A1
(de)
|
2011-09-14 |
2019-09-04 |
Translate Bio MA, Inc. |
Multimere oligonukleotidverbindungen
|
|
WO2013040499A1
(en)
|
2011-09-14 |
2013-03-21 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
|
US9580713B2
(en)
|
2011-09-17 |
2017-02-28 |
Yale University |
Fluoride-responsive riboswitches, fluoride transporters, and methods of use
|
|
EP2766482B1
(de)
|
2011-10-11 |
2016-12-07 |
The Brigham and Women's Hospital, Inc. |
Mikro-rnas in neurodegenerativen erkrankungen
|
|
KR102102862B1
(ko)
|
2011-10-14 |
2020-04-22 |
제넨테크, 인크. |
항-HtrA1 항체 및 사용 방법
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
US9243291B1
(en)
|
2011-12-01 |
2016-01-26 |
Isis Pharmaceuticals, Inc. |
Methods of predicting toxicity
|
|
CA2895077A1
(en)
|
2011-12-12 |
2013-06-20 |
Beverly Packard |
In vivo delivery of oligonucleotides
|
|
WO2013101935A1
(en)
|
2011-12-27 |
2013-07-04 |
Ibis Biosciences, Inc. |
Bioagent detection oligonucleotides
|
|
IL266882B2
(en)
|
2012-01-11 |
2025-11-01 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulation of ikbkap splicing
|
|
EP3434789A1
(de)
|
2012-01-13 |
2019-01-30 |
Data2Bio |
Genotypisierung durch eine sequenzierung der nächsten generation
|
|
SG11201405669XA
(en)
|
2012-03-13 |
2014-10-30 |
Swift Biosciences Inc |
Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
|
|
JP2015511494A
(ja)
|
2012-03-15 |
2015-04-20 |
キュアナ,インク. |
脳由来神経栄養因子(bdnf)に対する天然アンチセンス転写物の阻害によるbdnf関連の疾患の処置
|
|
CA2907072A1
(en)
|
2012-03-16 |
2013-09-19 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of dmpk
|
|
AU2013202595B2
(en)
|
2012-03-30 |
2016-04-21 |
Biogen Ma Inc. |
Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2013154798A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
WO2013159091A2
(en)
|
2012-04-20 |
2013-10-24 |
Aptamir Therapeutics, Inc. |
Mirna modulators of thermogenesis
|
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
US9273949B2
(en)
|
2012-05-11 |
2016-03-01 |
Vanderbilt University |
Backscattering interferometric methods
|
|
CA2873794A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating smn gene family expression
|
|
US20150133362A1
(en)
|
2012-05-16 |
2015-05-14 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
|
WO2013173789A2
(en)
|
2012-05-17 |
2013-11-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
|
WO2013181665A1
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
WO2013181666A2
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
WO2013184209A1
(en)
|
2012-06-04 |
2013-12-12 |
Ludwig Institute For Cancer Research Ltd. |
Mif for use in methods of treating subjects with a neurodegenerative disorder
|
|
WO2013185097A1
(en)
|
2012-06-08 |
2013-12-12 |
The Regents Of The University Of Michigan |
Ultrasound-triggerable agents for tissue engineering
|
|
RU2693381C2
(ru)
|
2012-07-13 |
2019-07-02 |
Уэйв Лайф Сайенсес Лтд. |
Асимметричная вспомогательная группа
|
|
SG11201500232UA
(en)
|
2012-07-13 |
2015-04-29 |
Wave Life Sciences Pte Ltd |
Chiral control
|
|
SG11201500243WA
(en)
|
2012-07-13 |
2015-04-29 |
Shin Nippon Biomedical Lab Ltd |
Chiral nucleic acid adjuvant
|
|
US20140038182A1
(en)
|
2012-07-17 |
2014-02-06 |
Dna Logix, Inc. |
Cooperative primers, probes, and applications thereof
|
|
WO2014022852A1
(en)
|
2012-08-03 |
2014-02-06 |
Aptamir Therapeutics, Inc. |
Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
|
|
US9403865B2
(en)
|
2012-08-15 |
2016-08-02 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
LT3421602T
(lt)
|
2012-09-06 |
2021-05-25 |
The University Of Chicago |
Priešprasmiai polinukleotidai, skirti indukuoti egzono praleidimą ir distrofijų gydymo būdai
|
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
|
EP2906255B1
(de)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense-verbindungen und verwendungen davon
|
|
EP3459549B1
(de)
|
2012-10-12 |
2022-04-06 |
Ionis Pharmaceuticals, Inc. |
Selektive antisense-verbindungen und verwendungen davon
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2912179A4
(de)
|
2012-10-26 |
2016-10-12 |
Geron Corp |
C-myc-antisense-oligonukleotide und verfahren zur verwendung davon zur behandlung von auf das zellwachstum wirkenden erkrankungen
|
|
HK1214830A1
(zh)
|
2012-11-05 |
2016-08-05 |
Foundation Medicine, Inc. |
新型ntrk1融合分子及其应用
|
|
EP4223770A3
(de)
|
2012-11-05 |
2023-10-18 |
Foundation Medicine, Inc. |
Neuartige fusionsmoleküle und verwendungen davon
|
|
US9695475B2
(en)
|
2012-12-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Competitive modulation of microRNAs
|
|
AU2014207342C1
(en)
|
2013-01-18 |
2019-04-04 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
US10260069B2
(en)
|
2013-02-04 |
2019-04-16 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
US20150366890A1
(en)
|
2013-02-25 |
2015-12-24 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
|
EP2970970B1
(de)
|
2013-03-14 |
2018-12-12 |
Andes Biotechnologies Global, Inc. |
Antisense-oligonukleotide zur behandlung von krebsstammzellen
|
|
WO2014160129A2
(en)
|
2013-03-14 |
2014-10-02 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
US10066269B2
(en)
|
2013-03-14 |
2018-09-04 |
Andes Biotechnologies Global, Inc. |
Methods for detecting and treating multiple myeloma
|
|
US9644207B2
(en)
|
2013-03-14 |
2017-05-09 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Tau expression
|
|
WO2014152054A1
(en)
|
2013-03-15 |
2014-09-25 |
Bio-Rad Laboratories, Inc. |
Digital assays for mutation detection
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
WO2014160871A2
(en)
|
2013-03-27 |
2014-10-02 |
The General Hospital Corporation |
Methods and agents for treating alzheimer's disease
|
|
EP4286517A3
(de)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutische verwendungen einer genomänderung mit crispr-/cas-systemen
|
|
US9677075B2
(en)
|
2013-04-23 |
2017-06-13 |
Northwestern University |
Metal-ligand coordination polymer nanoparticles and methods for making
|
|
KR20160002977A
(ko)
*
|
2013-05-01 |
2016-01-08 |
아이시스 파마수티컬즈 인코포레이티드 |
조성물 및 방법
|
|
AU2014268529C1
(en)
|
2013-05-22 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
TMPRSS6 iRNA compositions and methods of use thereof
|
|
PT2999785T
(pt)
|
2013-05-22 |
2018-07-09 |
Alnylam Pharmaceuticals Inc |
Composições de irna de serpina1 e métodos de uso das mesmas
|
|
EP3004396B1
(de)
|
2013-06-06 |
2019-10-16 |
The General Hospital Corporation |
Zusammensetzungen zur krebsbehandlung
|
|
ES2862125T3
(es)
|
2013-06-13 |
2021-10-07 |
Antisense Therapeutics Ltd |
Terapia combinada para acromegalia
|
|
WO2014205451A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
|
US10077236B2
(en)
|
2013-07-15 |
2018-09-18 |
The Regents Of The University Of California |
Azacyclic constrained analogs of FTY720
|
|
TWI772856B
(zh)
|
2013-07-19 |
2022-08-01 |
美商百健Ma公司 |
用於調節τ蛋白表現之組合物
|
|
EP3027617B1
(de)
|
2013-07-31 |
2026-02-18 |
Ionis Pharmaceuticals, Inc. |
Verfahren und verbindungen für erkrankungen im zusammenhang mit repeat-expansion
|
|
GB201313897D0
(en)
*
|
2013-08-02 |
2013-09-18 |
Maersk Olie & Gas |
Conformance control in enhanced oil recovery
|
|
LT3041854T
(lt)
|
2013-08-08 |
2020-03-25 |
The Scripps Research Institute |
Nukleorūgščių specifinės vietos žymėjimo fermentais in vitro būdas, įvedant nenatūralius nukleotidus
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
SG11201601654TA
(en)
|
2013-09-09 |
2016-04-28 |
Melinta Therapeutics Inc |
Antimicrobial compunds and methods of making and using the same
|
|
JP2016529325A
(ja)
|
2013-09-09 |
2016-09-23 |
メリンタ セラピューティクス,インコーポレイテッド |
抗微生物化合物ならびにそれの製造方法および使用方法
|
|
WO2015042447A1
(en)
|
2013-09-20 |
2015-03-26 |
Isis Pharmaceuticals, Inc. |
Targeted therapeutic nucleosides and their use
|
|
EP3052626A1
(de)
|
2013-10-02 |
2016-08-10 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der lect2-genexpression
|
|
JP6613227B2
(ja)
|
2013-10-04 |
2019-11-27 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Alas1遺伝子の発現を阻害する組成物および方法
|
|
EP3055426B1
(de)
|
2013-10-09 |
2019-06-19 |
The United States of America as represented by The Secretary Department of Health and Human Services |
Nachweis von hepatitis delta virus (hdv) zur diagnose und behandlung von sjögren-syndrom und lymphom
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
US10053692B2
(en)
|
2013-10-21 |
2018-08-21 |
The General Hospital Corporation |
Methods relating to circulating tumor cell clusters and the treatment of cancer
|
|
US10301622B2
(en)
|
2013-11-04 |
2019-05-28 |
Northwestern University |
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
|
|
EP3066219B1
(de)
|
2013-11-08 |
2018-12-26 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur detektion von oligonukleotiden
|
|
WO2015084884A2
(en)
|
2013-12-02 |
2015-06-11 |
Isis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
WO2015084897A2
(en)
|
2013-12-02 |
2015-06-11 |
Mirimmune, Llc |
Immunotherapy of cancer
|
|
MX389323B
(es)
|
2013-12-03 |
2025-03-20 |
Univ Northwestern |
Particulas liposomales, metodos para elaborarlas y sus usos.
|
|
WO2015085183A2
(en)
|
2013-12-06 |
2015-06-11 |
Swift Biosciences, Inc. |
Cleavable competitor polynucleotides
|
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
|
WO2015089368A2
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
|
CN106456694B
(zh)
|
2013-12-20 |
2020-06-30 |
通用医疗公司 |
与循环肿瘤细胞相关的方法和测定法
|
|
JPWO2015108047A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
EP3102197B1
(de)
|
2014-02-04 |
2018-08-29 |
Genentech, Inc. |
Smoothened-mutant und verfahren zur verwendung davon
|
|
CN118845818A
(zh)
|
2014-02-11 |
2024-10-29 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
|
WO2015142910A1
(en)
|
2014-03-17 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3978610A3
(de)
|
2014-03-19 |
2022-08-24 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen zur modulierung der ataxin-2-expression
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
SI3126499T1
(sl)
|
2014-04-01 |
2020-09-30 |
Biogen Ma Inc. |
Sestave za moduliranje izražanja SOD-1
|
|
TWI638047B
(zh)
|
2014-04-09 |
2018-10-11 |
史基普研究協會 |
藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中
|
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
EP3647318B1
(de)
|
2014-04-28 |
2021-06-30 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomerverbindungen
|
|
CA2947270A1
(en)
|
2014-04-28 |
2015-11-05 |
Rxi Pharmaceuticals Corporation |
Methods for treating cancer using nucleic acids targeting mdm2 or mycn
|
|
RU2724527C2
(ru)
|
2014-05-01 |
2020-06-23 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии рецептора гормона роста
|
|
JP2017521045A
(ja)
|
2014-05-01 |
2017-08-03 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
アンジオポエチン様因子3発現を調節するための組成物及び方法
|
|
CN110724687B
(zh)
|
2014-05-01 |
2023-10-13 |
Ionis制药公司 |
用于调节补体因子b表达的组合物和方法
|
|
TW201607559A
(zh)
|
2014-05-12 |
2016-03-01 |
阿尼拉製藥公司 |
治療serpinc1相關疾患之方法和組成物
|
|
US10570169B2
(en)
|
2014-05-22 |
2020-02-25 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
|
CN112852809A
(zh)
|
2014-05-22 |
2021-05-28 |
阿尔尼拉姆医药品有限公司 |
血管紧张素原(AGT)iRNA组合物及其使用方法
|
|
KR20170031668A
(ko)
|
2014-06-02 |
2017-03-21 |
칠드런'즈 메디컬 센터 코포레이션 |
면역 조절을 위한 방법 및 조성물
|
|
CA2953216C
(en)
|
2014-06-04 |
2020-12-22 |
Exicure, Inc. |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
|
HRP20220379T1
(hr)
|
2014-06-10 |
2022-05-27 |
Erasmus University Medical Center Rotterdam |
Antisense oligonukleotidi korisni u liječenju pompeove bolesti
|
|
CN106414738A
(zh)
|
2014-06-24 |
2017-02-15 |
雅培分子公司 |
人kras中单核苷酸多态性的检测
|
|
EP3760208B1
(de)
|
2014-06-25 |
2024-05-29 |
The General Hospital Corporation |
Targeting von humanem satellit ii (hsatii)
|
|
US9951327B1
(en)
|
2014-07-17 |
2018-04-24 |
Integrated Dna Technologies, Inc. |
Efficient and rapid method for assembling and cloning double-stranded DNA fragments
|
|
USRE50320E1
(en)
|
2014-07-31 |
2025-03-04 |
Uab Research Foundation |
APOE mimetic peptides and higher potency to clear plasma cholesterol
|
|
CN106794256B
(zh)
|
2014-08-19 |
2021-04-30 |
西北大学 |
蛋白质/寡核苷酸核-壳纳米颗粒治疗剂
|
|
US9617541B2
(en)
|
2014-08-20 |
2017-04-11 |
Northwestern University |
Biocompatible infinite coordination polymer nanoparticle-nucleic acid conjugates for antisense gene regulation
|
|
EP4137138A1
(de)
|
2014-08-29 |
2023-02-22 |
Alnylam Pharmaceuticals, Inc. |
Verfahren zum behandeln von transthyretin (ttr)-vermittelter amyloidose
|
|
JP2017526367A
(ja)
|
2014-08-29 |
2017-09-14 |
チルドレンズ メディカル センター コーポレーション |
癌の処置のための方法および組成物
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
KR102506169B1
(ko)
|
2014-09-05 |
2023-03-08 |
피오 파마슈티칼스 코프. |
Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
|
|
WO2016040748A1
(en)
|
2014-09-12 |
2016-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for detection of smn protein in a subject and treatment of a subject
|
|
EP3191591A1
(de)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete polynukleotidwirkstoffe und verfahren zur verwendung davon
|
|
EP3663403A1
(de)
|
2014-09-26 |
2020-06-10 |
University of Massachusetts |
Rna-modulierende stoffe
|
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
EP3904519A1
(de)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynukleotidwirkstoffe mit abzielung auf serpinc1 (at3) und verfahren zur verwendung davon
|
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
|
WO2016077540A1
(en)
|
2014-11-12 |
2016-05-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of comp
|
|
CA2964979A1
(en)
|
2014-11-14 |
2016-05-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用方法
|
|
AU2015349680A1
(en)
|
2014-11-21 |
2017-06-08 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
AU2015360794B2
(en)
|
2014-12-08 |
2021-07-08 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
|
CN107532162A
(zh)
|
2014-12-12 |
2018-01-02 |
托德·M·伍尔夫 |
用于利用寡核苷酸编辑细胞中核酸的组合物和方法
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
EP3247988A4
(de)
|
2015-01-23 |
2018-12-19 |
Vanderbilt University |
Robustes interferometer und verfahren zur verwendung davon
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
WO2016135559A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
BR112017019349A2
(pt)
|
2015-03-11 |
2018-06-05 |
Melinta Therapeutics Inc |
compostos antimicrobianos e métodos de fabricação e uso dos mesmos
|
|
EP4269601A3
(de)
|
2015-03-27 |
2024-01-10 |
President and Fellows of Harvard College |
Modifizierte t-zellen und verfahren zur herstellung und verwendung davon
|
|
EP3283502A4
(de)
|
2015-04-07 |
2019-04-03 |
The General Hospital Corporation |
Verfahren zur reaktivierung von genen auf dem inaktiven x-chromosom
|
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
WO2016164602A1
(en)
|
2015-04-08 |
2016-10-13 |
The University Of Chicago |
Compositions and methods for correcting limb girdle muscular dystrophy type 2c using exon skipping
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
AU2016282986A1
(en)
|
2015-06-26 |
2018-02-01 |
Beth Israel Deaconess Medical Center, Inc. |
Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
|
|
IL318703A
(en)
|
2015-06-29 |
2025-03-01 |
Caris Science Inc |
Therapeutic oligonucleotides
|
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
修飾crispr rna及び修飾単一crispr rnaならびにその使用
|
|
CA2991598A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
US20180312845A1
(en)
|
2015-07-10 |
2018-11-01 |
Ionis Pharmaceuticals, Inc. |
Modulators of diacyglycerol acyltransferase 2 (dgat2)
|
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
AU2016298317B2
(en)
|
2015-07-28 |
2021-02-18 |
Caris Science, Inc. |
Targeted oligonucleotides
|
|
WO2017021961A1
(en)
|
2015-08-04 |
2017-02-09 |
Yeda Research And Development Co. Ltd. |
Methods of screening for riboswitches and attenuators
|
|
CN114525280A
(zh)
|
2015-09-02 |
2022-05-24 |
阿尔尼拉姆医药品有限公司 |
程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
|
|
EP3950003A1
(de)
|
2015-09-14 |
2022-02-09 |
The Board of Regents of the University of Texas System |
Lipokationische dendrimere und verwendungen davon
|
|
AU2016339053A1
(en)
|
2015-09-24 |
2018-04-12 |
Crispr Therapeutics Ag |
Novel family of RNA-programmable endonucleases and their uses in genome editing and other applications
|
|
KR20180051626A
(ko)
|
2015-09-24 |
2018-05-16 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Kras 발현의 조절제
|
|
MX394367B
(es)
|
2015-09-24 |
2025-03-24 |
Univ California |
Moléculas tipo esfingolípidos sintéticas, fármacos, métodos de su síntesis y usos de los mismos.
|
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
|
WO2017058672A1
(en)
|
2015-09-29 |
2017-04-06 |
The Regents Of The University Of Michigan Office Of Technology Transfer |
Biodegradable hydrogel for tissue expansion
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
US11021707B2
(en)
|
2015-10-19 |
2021-06-01 |
Phio Pharmaceuticals Corp. |
Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
|
|
AU2016344609B2
(en)
|
2015-10-28 |
2022-05-12 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
WO2017075212A1
(en)
|
2015-10-30 |
2017-05-04 |
Genentech, Inc. |
Anti-htra1 antibodies and methods of use thereof
|
|
EP3370734B1
(de)
|
2015-11-05 |
2023-01-04 |
Children's Hospital Los Angeles |
Antisense-oligo zur verwendung bei der behandlung von akuter myeloischer leukämie
|
|
CA2999341A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Modulating apolipoprotein (a) expression
|
|
CN109328231A
(zh)
|
2015-11-06 |
2019-02-12 |
克里斯普治疗股份公司 |
用于治疗1a型糖原贮积病的材料和方法
|
|
US20190046555A1
(en)
|
2015-11-06 |
2019-02-14 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds for use in therapy
|
|
US11001622B2
(en)
|
2015-11-19 |
2021-05-11 |
The Brigham And Women's Hospital, Inc. |
Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein
|
|
KR20250044471A
(ko)
|
2015-11-30 |
2025-03-31 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
|
WO2017093804A2
(en)
|
2015-12-01 |
2017-06-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of alpha-1 antitrypsin deficiency
|
|
US11058709B1
(en)
|
2015-12-04 |
2021-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
KR20180095843A
(ko)
|
2015-12-07 |
2018-08-28 |
젠자임 코포레이션 |
Serpinc1-연관 장애의 치료를 위한 방법 및 조성물
|
|
EP3387127A1
(de)
|
2015-12-07 |
2018-10-17 |
Erasmus University Medical Center Rotterdam |
Enzymatische ersatztherapie und antisense-therapie für pompe-krankheit
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
AU2016376191A1
(en)
|
2015-12-23 |
2018-07-12 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
|
WO2017117496A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
EP3400300A4
(de)
|
2016-01-05 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur reduzierung der lrrk2-expression
|
|
US10627396B2
(en)
|
2016-01-29 |
2020-04-21 |
Vanderbilt University |
Free-solution response function interferometry
|
|
US20190038771A1
(en)
|
2016-02-02 |
2019-02-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
JP2019509721A
(ja)
|
2016-02-04 |
2019-04-11 |
キュリス,インコーポレイテッド |
突然変異体スムースンド及びその使用方法
|
|
WO2017141109A1
(en)
|
2016-02-18 |
2017-08-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
PT3419665T
(pt)
|
2016-02-25 |
2025-01-06 |
Brigham & Womens Hospital Inc |
Métodos de tratamento para a fibrose dirigida ao smoc2
|
|
WO2017152182A1
(en)
|
2016-03-04 |
2017-09-08 |
Rhode Island Hospital |
Targeting microrna for cancer treatment
|
|
AU2017229778A1
(en)
|
2016-03-09 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for inhibiting PMP22 expression
|
|
US11083799B2
(en)
|
2016-03-16 |
2021-08-10 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
|
US10961271B2
(en)
|
2016-03-16 |
2021-03-30 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
US10577607B2
(en)
|
2016-03-16 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of DYRK1B expression
|
|
EP3430137A4
(de)
|
2016-03-18 |
2019-11-06 |
Caris Science, Inc. |
Oligonukleotidsonden und verwendungen davon
|
|
WO2017180915A2
(en)
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
ES2933435T3
(es)
|
2016-04-13 |
2023-02-08 |
Ionis Pharmaceuticals Inc |
Métodos para reducir la expresión de C9ORF72
|
|
ES2979222T3
(es)
|
2016-04-18 |
2024-09-24 |
Vertex Pharma |
Materiales y métodos para el tratamiento de hemoglobinopatías
|
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
CA3023317A1
(en)
|
2016-05-06 |
2017-11-09 |
Melinta Therapeutics, Inc. |
Antimicrobials and methods of making and using same
|
|
WO2017192820A1
(en)
|
2016-05-06 |
2017-11-09 |
Ionis Pharmaceuticals, Inc. |
Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
|
|
WO2017201076A1
(en)
|
2016-05-16 |
2017-11-23 |
The Board Of Regents Of The University Of Texas System |
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
|
|
EP3464597B1
(de)
|
2016-05-25 |
2022-08-03 |
Caris Science, Inc. |
Selectionsverfahren von oligonukleotidsonden und verwendungen davon
|
|
WO2017214518A1
(en)
|
2016-06-10 |
2017-12-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLETMENT COMPONENT C5 iRNA COMPOSTIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
|
CA3027953A1
(en)
|
2016-06-15 |
2017-12-21 |
Streck, Inc. |
Assays and methods for determining microbial resistance
|
|
AU2017286811A1
(en)
|
2016-06-17 |
2018-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
HUE060123T2
(hu)
|
2016-06-24 |
2023-01-28 |
Scripps Research Inst |
Új nukleozid-trifoszfát-transzporter és alkalmazásai
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
EP3478828B1
(de)
|
2016-06-29 |
2024-09-04 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von friedreich-ataxie und anderen verwandten erkrankungen
|
|
EP3478313B1
(de)
|
2016-06-29 |
2022-05-04 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von amyotropher lateralsklerose (als) und anderen verwandten erkrankungen
|
|
CA3029141A1
(en)
|
2016-07-06 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of pain related disorders
|
|
DK3481856T3
(da)
|
2016-07-06 |
2025-11-10 |
Vertex Pharma |
Materialer og metoder til behandling af smerterelaterede lidelser
|
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
|
US11253601B2
(en)
|
2016-07-11 |
2022-02-22 |
Translate Bio Ma, Inc. |
Nucleic acid conjugates and uses thereof
|
|
HUE060831T2
(hu)
|
2016-07-15 |
2023-04-28 |
Ionis Pharmaceuticals Inc |
Vegyületek és eljárások SMN2 modulálására
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
|
CN110023321A
(zh)
|
2016-08-17 |
2019-07-16 |
索尔斯蒂斯生物有限公司 |
多核苷酸构建体
|
|
US11364304B2
(en)
|
2016-08-25 |
2022-06-21 |
Northwestern University |
Crosslinked micellar spherical nucleic acids
|
|
SG10201607303YA
(en)
|
2016-09-01 |
2018-04-27 |
Agency Science Tech & Res |
Antisense oligonucleotides to induce exon skipping
|
|
WO2018055577A1
(en)
|
2016-09-23 |
2018-03-29 |
Synthena Ag |
Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof
|
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
SG10201609048RA
(en)
|
2016-10-28 |
2018-05-30 |
Agency Science Tech & Res |
Antisense oligonucleotides
|
|
WO2018081817A2
(en)
|
2016-10-31 |
2018-05-03 |
University Of Massachusetts |
Targeting microrna-101-3p in cancer therapy
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
US11447519B2
(en)
|
2016-11-10 |
2022-09-20 |
San Diego State University Research Foundation |
Compounds for fluorescence sensing of duplex formation
|
|
TW202313978A
(zh)
|
2016-11-23 |
2023-04-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
EP3548620A4
(de)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
Modulation der lnc05-expression
|
|
JP7206214B2
(ja)
|
2016-12-13 |
2023-01-17 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
|
|
TWI790217B
(zh)
|
2016-12-16 |
2023-01-21 |
美商阿尼拉製藥公司 |
使用甲狀腺素運載蛋白(TTR)iRNA組成物於治療或預防TTR相關疾病之方法
|
|
SG11201906735RA
(en)
|
2017-01-23 |
2019-08-27 |
Regeneron Pharma |
Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
|
|
CA3054031A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
EP3585900B1
(de)
|
2017-02-22 |
2022-12-21 |
CRISPR Therapeutics AG |
Materialien und methoden zur behandlung von spinocerebellar ataxia typ 2 (sca2) und anderen spinocerebellar ataxia typ 2 protein (atxn2) gen verwandten erkrankungen oder störungen
|
|
EP3585898A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von spinozerebellärer ataxie typ 1 (sca1) und anderen mit dem gen des proteins von spinozerebellärer ataxie typ 1 (atxn1) assoziierten erkrankungen oder störungen
|
|
US11407997B2
(en)
|
2017-02-22 |
2022-08-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
|
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
|
US20180284123A1
(en)
|
2017-03-30 |
2018-10-04 |
California Institute Of Technology |
Barcoded rapid assay platform useful for efficient analysis of candidate molecules and methods of making and using the platform
|
|
WO2018191603A1
(en)
|
2017-04-14 |
2018-10-18 |
University Of Massachusetts |
Targeting cell tropism receptors to inhibit cytomegalovirus infection
|
|
CN110770345A
(zh)
|
2017-04-14 |
2020-02-07 |
托尔奈公司 |
免疫调节多核苷酸、抗体缀合物及其使用方法
|
|
KR102720270B1
(ko)
|
2017-04-18 |
2024-10-23 |
알닐람 파마슈티칼스 인코포레이티드 |
B형 간염 바이러스 (hbv)에 감염된 대상체의 치료 방법
|
|
WO2018195355A1
(en)
|
2017-04-19 |
2018-10-25 |
Rxi Pharmaceuticals Corporation |
Topical delivery of nucleic acid compounds
|
|
US11872239B2
(en)
|
2017-04-20 |
2024-01-16 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-DNA nucleosides and uses thereof
|
|
WO2018193428A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
|
EP3612232A1
(de)
|
2017-04-21 |
2020-02-26 |
The Broad Institute, Inc. |
Gezielte abgabe an beta-zellen
|
|
US11433131B2
(en)
|
2017-05-11 |
2022-09-06 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (SNAs)
|
|
CN110914289B
(zh)
|
2017-05-12 |
2024-05-14 |
克里斯珀医疗股份公司 |
用于工程化细胞的材料和方法及其在免疫肿瘤学中的用途
|
|
WO2019006455A1
(en)
|
2017-06-30 |
2019-01-03 |
Solstice Biologics, Ltd. |
AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
|
|
KR20200026960A
(ko)
|
2017-07-10 |
2020-03-11 |
젠자임 코포레이션 |
혈우병을 갖는 대상체에서 출혈 사건을 치료하기 위한 방법 및 조성물
|
|
KR20250171416A
(ko)
|
2017-07-11 |
2025-12-08 |
신톡스, 인크. |
비천연 뉴클레오티드의 도입 및 그의 방법
|
|
EP3651774A4
(de)
|
2017-07-11 |
2021-07-07 |
The Scripps Research Institute |
Integration von unnatürlichen nukleotiden und anwendungsverfahren in vivo
|
|
CA3069868A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
|
|
KR20200028997A
(ko)
|
2017-07-13 |
2020-03-17 |
노오쓰웨스턴 유니버시티 |
올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
|
|
BR112020002272A2
(pt)
|
2017-08-03 |
2020-07-28 |
Synthorx, Inc. |
conjugados de citocina para o tratamento de doenças autoimunes
|
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
|
WO2019055460A1
(en)
|
2017-09-13 |
2019-03-21 |
The Children's Medical Center Corporation |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TRANSPOSON-ASSOCIATED DISEASES
|
|
KR20250046363A
(ko)
|
2017-09-19 |
2025-04-02 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
|
|
KR102728416B1
(ko)
|
2017-10-17 |
2024-11-11 |
크리스퍼 테라퓨틱스 아게 |
A형 혈우병을 위한 유전자 편집용 조성물 및 방법
|
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
|
EP3704252A1
(de)
|
2017-11-01 |
2020-09-09 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c3 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon
|
|
WO2019092505A1
(en)
|
2017-11-09 |
2019-05-16 |
Casebia Therapeutics Llp |
Self-inactivating (sin) crispr/cas or crispr/cpf1 systems and uses thereof
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
US20200385719A1
(en)
|
2017-11-16 |
2020-12-10 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
|
MA50877A
(fr)
|
2017-11-21 |
2020-09-30 |
Bayer Healthcare Llc |
Matériaux et méthodes pour le traitement de la rétinite pigmentaire autosomique dominante
|
|
CA3084955A1
(en)
|
2017-12-05 |
2019-06-13 |
Vertex Pharmaceuticals Incorporated |
Crispr-cas9 modified cd34+ human hematopoietic stem and progenitor cells and uses thereof
|
|
CA3084825A1
(en)
|
2017-12-14 |
2019-06-20 |
Crispr Therapeutics Ag |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
|
EP3724206B1
(de)
|
2017-12-14 |
2023-06-28 |
Ionis Pharmaceuticals, Inc. |
Konjugierte antisense-verbindungen und deren verwendung
|
|
MX2020006012A
(es)
|
2017-12-18 |
2020-09-14 |
Alnylam Pharmaceuticals Inc |
Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas.
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
CN111836892B
(zh)
|
2017-12-21 |
2025-03-11 |
克里斯珀医疗股份公司 |
用于治疗2a型乌谢尔综合征的材料和方法
|
|
EP3728595A1
(de)
|
2017-12-21 |
2020-10-28 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung des usher-syndroms des typs 2a und/oder von nichtsyndromaler autosomaler rezessiver retinitis pigmentosa (arrp)
|
|
CN112105627B
(zh)
|
2017-12-29 |
2024-07-02 |
斯克利普斯研究所 |
非天然碱基对组合物及使用方法
|
|
US12178855B2
(en)
|
2018-01-10 |
2024-12-31 |
Translate Bio Ma, Inc. |
Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
|
|
MA51637A
(fr)
|
2018-01-12 |
2020-11-18 |
Bayer Healthcare Llc |
Compositions et méthodes pour l'édition génique par ciblage de la transferrine
|
|
CN111819283A
(zh)
|
2018-01-12 |
2020-10-23 |
百时美施贵宝公司 |
靶向α-突触核蛋白的反义寡核苷酸及其用途
|
|
SG11202006526YA
(en)
|
2018-01-12 |
2020-08-28 |
Bristol Myers Squibb Co |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
|
KR20200113214A
(ko)
|
2018-01-15 |
2020-10-06 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Dnm2 발현의 조절제
|
|
JP7652567B2
(ja)
|
2018-01-19 |
2025-03-27 |
シンセナ アーゲー |
トリシクロ-dnaヌクレオシド前駆体およびそれを調製するためのプロセス
|
|
WO2019144061A1
(en)
|
2018-01-19 |
2019-07-25 |
Duke University |
Genome engineering with crispr-cas systems in eukaryotes
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
MA51788A
(fr)
|
2018-02-05 |
2020-12-16 |
Vertex Pharma |
Substances et méthodes pour traiter des hémoglobinopathies
|
|
WO2019150196A1
(en)
|
2018-02-05 |
2019-08-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
AU2019218987B2
(en)
|
2018-02-12 |
2025-04-24 |
Ionis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
|
US20210130824A1
(en)
|
2018-02-16 |
2021-05-06 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing by targeting fibrinogen-alpha
|
|
TWI834636B
(zh)
|
2018-02-26 |
2024-03-11 |
美商欣爍克斯公司 |
Il-15結合物及其用途
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
EP3759127A4
(de)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation des amyloid-beta-vorläuferproteins
|
|
WO2019183150A1
(en)
|
2018-03-19 |
2019-09-26 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and uses thereof
|
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
|
AU2019242912B2
(en)
|
2018-03-28 |
2025-07-17 |
Board Of Regents, The University Of Texas System |
Identification of epigenetic alterations in DNA isolated from exosomes
|
|
EP4051799A2
(de)
|
2018-03-30 |
2022-09-07 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Aptamere zur gezielten aktivierung von t-zellvermittelter immunität
|
|
US20210155959A1
(en)
|
2018-04-06 |
2021-05-27 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
EP3775204A4
(de)
|
2018-04-11 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Modulatoren der ezh2-expression
|
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
|
EP3784259A4
(de)
|
2018-04-27 |
2021-12-29 |
Seattle Children's Hospital (DBA Seattle Children's Research Institute) |
Rapamycinresistente zellen
|
|
WO2019213016A1
(en)
|
2018-04-30 |
2019-11-07 |
The Children's Hospital Of Philadelphia |
Methods of improving anemias by combining agents
|
|
EP3788366B1
(de)
|
2018-05-03 |
2023-05-17 |
The Trustees of Wheaton College |
Verbesserte membranen für detektionsanwendungen mit nanoporen
|
|
JOP20200283A1
(ar)
|
2018-05-09 |
2020-11-08 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير الوراثي عن atxn3
|
|
BR112020020957B1
(pt)
|
2018-05-09 |
2022-05-10 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
|
|
TWI851574B
(zh)
|
2018-05-14 |
2024-08-11 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
|
JP7557378B2
(ja)
|
2018-06-14 |
2024-09-27 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Stmn2発現を増加させるための化合物及び方法
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
EP3823725A4
(de)
|
2018-07-17 |
2023-05-10 |
Aronora, Inc. |
Verfahren zur sicheren reduzierung von thrombopoietin
|
|
AU2019310097A1
(en)
|
2018-07-25 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN2 expression
|
|
WO2020036862A1
(en)
|
2018-08-13 |
2020-02-20 |
Alnylam Pharmaceuticals, Inc. |
HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
AR115960A1
(es)
|
2018-08-16 |
2021-03-17 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para inhibir la expresión del gen lect2
|
|
EP3840733A4
(de)
|
2018-08-20 |
2022-07-20 |
Rogcon, Inc. |
Gegen scn2a gerichtete antisense-oligonukleotide zur behandlung von scn1a-enzephalopathien
|
|
US12281308B2
(en)
|
2018-08-29 |
2025-04-22 |
University Of Massachusetts |
Inhibition of protein kinases to treat Friedreich ataxia
|
|
EP3620520A1
(de)
|
2018-09-10 |
2020-03-11 |
Universidad del Pais Vasco |
Neuartiges target zur behandlung einer stoffwechselerkrankung in einem individuum
|
|
JP7535310B2
(ja)
|
2018-09-14 |
2024-08-16 |
ノースウェスタン ユニバーシティ |
Dnaとのタンパク質重合のプログラミング
|
|
CA3105385A1
(en)
|
2018-09-18 |
2020-03-26 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
|
TWI856973B
(zh)
|
2018-09-19 |
2024-10-01 |
美商Ionis製藥公司 |
Pnpla3表現之調節劑
|
|
CA3292164A1
(en)
|
2018-09-25 |
2025-11-29 |
Co Diagnostics Inc |
Allele-specific design of cooperative primers for improved nucleic acid variant genotyping
|
|
BR112021007403A2
(pt)
|
2018-10-17 |
2021-12-07 |
Bayer Healthcare Llc |
Composições e métodos para entrega de transgenes
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
TW202031284A
(zh)
|
2018-11-08 |
2020-09-01 |
美商新索思股份有限公司 |
介白素10結合物及其用途
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
AR117094A1
(es)
|
2018-11-15 |
2021-07-07 |
Ionis Pharmaceuticals Inc |
Moduladores de expresión irf5
|
|
JP7455831B2
(ja)
|
2018-11-21 |
2024-03-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
プリオン発現を低減するための化合物及び方法
|
|
CA3121191A1
(en)
|
2018-11-28 |
2020-06-04 |
Crispr Therapeutics Ag |
Optimized mrna encoding cas9 for use in lnps
|
|
EP3894559A4
(de)
|
2018-12-03 |
2023-04-05 |
Triplet Therapeutics, Inc. |
Verfahren zur behandlung von störungen der trinukleotid-repeat-expansion im zusammenhang mit mlh3-aktivität
|
|
WO2020118259A1
(en)
|
2018-12-06 |
2020-06-11 |
Northwestern University |
Protein crystal engineering through dna hybridization interactions
|
|
RS67553B1
(sr)
|
2018-12-20 |
2026-01-30 |
Humabs Biomed Sa |
Kombinovana hbv terapija
|
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ, インコーポレイテッド |
Kcnt1関連障害の治療のための組成物及び方法
|
|
AU2019403447B2
(en)
|
2018-12-21 |
2023-07-27 |
Ionis Pharmaceuticals, Inc. |
Modulators of HSD17B13 expression
|
|
EP3897689B1
(de)
|
2018-12-21 |
2025-02-05 |
Northwestern University |
Verwendung von annexinen zur vorbeugung und behandlung von muskelmembranverletzungen
|
|
US20220062299A1
(en)
|
2018-12-26 |
2022-03-03 |
Northwestern University |
Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder
|
|
JP2022517270A
(ja)
|
2019-01-16 |
2022-03-07 |
ジェンザイム・コーポレーション |
Serpinc1 iRNA組成物およびその使用方法
|
|
BR112021013369A2
(pt)
|
2019-01-31 |
2021-09-21 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de yap1
|
|
US20200246467A1
(en)
|
2019-02-06 |
2020-08-06 |
Synthorx, Inc. |
Il-2 conjugates and methods of use thereof
|
|
SG11202108357PA
(en)
|
2019-02-15 |
2021-08-30 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
|
WO2020176771A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
|
US20220175956A1
(en)
|
2019-03-06 |
2022-06-09 |
Northwestern University |
Hairpin-like oligonucleotide-conjugated spherical nucleic acid
|
|
US12486536B2
(en)
|
2019-03-11 |
2025-12-02 |
Ochsner Health System |
MicroRNA regulatory network as biomarkers of seizure in patients with spontaneous intracerebral hemorrhage
|
|
AU2020239225A1
(en)
|
2019-03-12 |
2021-09-30 |
Bayer Healthcare Llc |
Novel high fidelity RNA-programmable endonuclease systems and uses thereof
|
|
CA3135180A1
(en)
|
2019-03-29 |
2020-10-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating ube3a-ats
|
|
CN114126628B
(zh)
|
2019-05-13 |
2025-04-18 |
维尔生物科技有限公司 |
用于治疗乙型肝炎病毒(hbv)感染的组合物及方法
|
|
SI3976791T1
(sl)
|
2019-05-28 |
2025-06-30 |
Ionis Pharmaceuticals, Inc. |
Spojine in postopki za zmanjševanje izražanja fus
|
|
EP3976834A1
(de)
|
2019-05-31 |
2022-04-06 |
Streck, Inc. |
Nachweis von antibiotikaresistenzgenen
|
|
JP7728181B2
(ja)
|
2019-06-14 |
2025-08-22 |
ザ スクリプス リサーチ インスティテュート |
半合成生物における複製、転写および翻訳のための試薬ならびに方法
|
|
EP3956450B1
(de)
|
2019-07-26 |
2025-08-13 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation von gfap
|
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2021022109A1
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP4013870A1
(de)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Irna-wirkstoffzusammensetzungen der kleinen ribosomalen proteinuntereinheit 25 (rps25) und verfahren zu ihrer verwendung
|
|
CA3150163A1
(en)
|
2019-08-15 |
2021-02-18 |
Synthorx, Inc. |
Immuno oncology combination therapies with il-2 conjugates
|
|
CN114555621B
(zh)
|
2019-08-15 |
2025-10-28 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
|
BR112022003046A8
(pt)
|
2019-08-23 |
2024-02-06 |
Synthorx Inc |
Conjugado de il-15, seu método de preparo e seus usos, bem como composição farmacêutica e método in vitro de expansão de uma ou mais das populações de células t
|
|
JP7805286B2
(ja)
|
2019-09-03 |
2026-01-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Lect2遺伝子の発現を阻害するための組成物および方法
|
|
EP4028060A1
(de)
|
2019-09-10 |
2022-07-20 |
Synthorx, Inc. |
Il-2-konjugate und verfahren zur verwendung zur behandlung von autoimmunerkrankungen
|
|
US12319711B2
(en)
|
2019-09-20 |
2025-06-03 |
Northwestern University |
Spherical nucleic acids with tailored and active protein coronae
|
|
US12503699B2
(en)
|
2019-10-04 |
2025-12-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing UGT1a1 gene expression
|
|
EP4045062A1
(de)
|
2019-10-14 |
2022-08-24 |
Astrazeneca AB |
Modulatoren der pnpla3-expression
|
|
EP4045652A1
(de)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen eines elements der solute-carrier-familie und verwendungsverfahren dafür
|
|
BR112022007540A2
(pt)
|
2019-10-22 |
2022-07-12 |
Alnylam Pharmaceuticals Inc |
Composições de irna de componente complementar c3 e métodos de uso das mesmas
|
|
US12378560B2
(en)
|
2019-10-29 |
2025-08-05 |
Northwestern University |
Sequence multiplicity within spherical nucleic acids
|
|
WO2021086623A1
(en)
|
2019-10-31 |
2021-05-06 |
The Trustees Of Wheaton College |
Design and characterization of multilayered structures for support of lipid bilayers
|
|
AR120341A1
(es)
|
2019-11-01 |
2022-02-09 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE AGENTES DE ARNi CONTRA LA HUNTINGTINA (HTT) Y SUS MÉTODOS DE USO
|
|
EP4051796A1
(de)
|
2019-11-01 |
2022-09-07 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zum unterdrücken der dnajb1-prkaca-fusionsgenexpression
|
|
CA3156405A1
(en)
|
2019-11-04 |
2021-05-14 |
Synthorx, Inc. |
Interleukin 10 conjugates and uses thereof
|
|
TW202526019A
(zh)
|
2019-11-13 |
2025-07-01 |
美商阿尼拉製藥公司 |
用於治療血管收縮素原相關病症之方法及組成物
|
|
EP4061945A1
(de)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3)-rnai-wirkstoffzusammensetzungen und verfahren zu deren verwendung
|
|
JP7684298B2
(ja)
|
2019-11-27 |
2025-05-27 |
クリスパー・セラピューティクス・アクチェンゲゼルシャフト |
Rna分子を合成する方法
|
|
BR112022011417A2
(pt)
|
2019-12-13 |
2022-08-30 |
Alnylam Pharmaceuticals Inc |
Composições do agente de irna da fase de leitura aberta 72 do cromossomo humano 9 (c9orf72) e métodos de uso das mesmas
|
|
WO2021126734A1
(en)
|
2019-12-16 |
2021-06-24 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
US20230054569A1
(en)
|
2019-12-18 |
2023-02-23 |
Alia Therapeutics Srl |
Compositions and methods for treating retinitis pigmentosa
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
US12503695B2
(en)
|
2020-01-27 |
2025-12-23 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
RAB13 and NET1 antisense oligonucleotides to treat metastatic cancer
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
WO2021163066A1
(en)
|
2020-02-10 |
2021-08-19 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing vegf-a expression
|
|
WO2021167841A1
(en)
|
2020-02-18 |
2021-08-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
|
CA3169523A1
(en)
|
2020-02-28 |
2021-09-02 |
Jaume Pons |
Transglutaminase-mediated conjugation
|
|
AR121446A1
(es)
|
2020-02-28 |
2022-06-08 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
|
EP4114947A1
(de)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Komplementkomponenten-c3-irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung oder prävention von mit komplementkomponenten-c3-assoziierten erkrankungen
|
|
WO2021178736A1
(en)
|
2020-03-06 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
コロナウイルスiRNA組成物およびその使用方法
|
|
WO2021202443A2
(en)
|
2020-03-30 |
2021-10-07 |
Alnylam Pharmaceucticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
WO2021202902A1
(en)
|
2020-04-01 |
2021-10-07 |
Alnylam Pharmaceuticals, Inc. |
ALPHA-2A ADRENERGIC RECEPTOR (ADRA2A) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
AU2021252545A1
(en)
|
2020-04-06 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing myoc expression
|
|
EP4133077A1
(de)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen mit transmembran-serinprotease 2 (tmprss2) und verfahren zur verwendung davon
|
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
KR20230008078A
(ko)
|
2020-04-07 |
2023-01-13 |
알닐람 파마슈티칼스 인코포레이티드 |
Scn9a 발현을 사일런싱하기 위한 조성물 및 방법
|
|
IL297483A
(en)
|
2020-04-21 |
2022-12-01 |
Flagship Pioneering Inc |
Bifunctional compounds and their uses
|
|
BR112022021813A2
(pt)
|
2020-04-27 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
|
|
JP2023523790A
(ja)
|
2020-04-30 |
2023-06-07 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体因子B(CFB)iRNA組成物およびその使用方法
|
|
AU2021264010A1
(en)
|
2020-05-01 |
2022-12-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating ATXN1
|
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
EP4150078A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten editierung von argininosuccinat-lyase (asl)
|
|
CA3162416C
(en)
|
2020-05-15 |
2023-07-04 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
|
EP4150086A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von leucinreicher repeat-kinase 2 (lrrk2)
|
|
EP4150076A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von methyl-cpg-bindendem protein 2 (mecp2)
|
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
AR122534A1
(es)
|
2020-06-03 |
2022-09-21 |
Triplet Therapeutics Inc |
Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
|
|
EP4162050A1
(de)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai-zusammensetzungen und verfahren zur verwendung davon zur verabreichung durch inhalation
|
|
EP4649951A2
(de)
|
2020-06-09 |
2025-11-19 |
Alnylam Pharmaceuticals, Inc. |
Sirna-zusammensetzungen und verfahren zur ausschaltung von polyglycerol-3-phosphat-acyltransferase-1, mitochondrien)-expression
|
|
CN116209760A
(zh)
|
2020-06-18 |
2023-06-02 |
阿尔尼拉姆医药品有限公司 |
黄嘌呤脱氢酶(XDH)iRNA组合物及其使用方法
|
|
CN116390943A
(zh)
|
2020-06-24 |
2023-07-04 |
维尔生物科技有限公司 |
工程化乙型肝炎病毒中和抗体和其用途
|
|
BR112022026236A2
(pt)
|
2020-06-25 |
2023-01-17 |
Synthorx Inc |
Terapia de combinação de imuno-oncologia com conjugados de il-2 e anticorpos anti-egfr
|
|
AU2021299290A1
(en)
|
2020-06-29 |
2023-01-05 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating PLP1
|
|
KR20230043914A
(ko)
|
2020-07-28 |
2023-03-31 |
아이오니스 파마수티컬즈, 인코포레이티드 |
App 발현을 감소시키기 위한 화합물 및 방법
|
|
CN116322707B
(zh)
|
2020-08-07 |
2026-02-03 |
艾欧尼斯制药公司 |
用于调节scn2a的化合物和方法
|
|
US12329828B2
(en)
|
2020-09-16 |
2025-06-17 |
San Diego State University (Sdsu) Foundation |
Pyrimidine nucleoside compounds for fluorescence imaging and spectroscopy
|
|
TW202227102A
(zh)
|
2020-09-22 |
2022-07-16 |
瑞典商阿斯特捷利康公司 |
治療脂肪肝病之方法
|
|
EP4217489A1
(de)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidylpeptidase 4 (dpp4)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
WO2022070107A1
(en)
|
2020-09-30 |
2022-04-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
|
EP3978608A1
(de)
|
2020-10-05 |
2022-04-06 |
SQY Therapeutics |
Oligomere verbindung zur dystrophinrettung in dmd-patienten während des skipping exon-51
|
|
TW202229552A
(zh)
|
2020-10-05 |
2022-08-01 |
美商艾拉倫製藥股份有限公司 |
G蛋白-偶合受體75(GPR75)iRNA組成物及其使用方法
|
|
WO2022076859A1
(en)
|
2020-10-09 |
2022-04-14 |
Synthorx, Inc. |
Immuno oncology therapies with il-2 conjugates
|
|
AU2021356693A1
(en)
|
2020-10-09 |
2023-06-15 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and pembrolizumab
|
|
IL301950B2
(en)
|
2020-10-09 |
2025-09-01 |
Univ Texas |
Pre-stabilized hmpv f proteins
|
|
WO2022087041A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
EP4232582A1
(de)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin-5b (muc5b)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
CA3196205A1
(en)
|
2020-10-23 |
2022-04-28 |
Floyd E. Romesberg |
Reverse transcription of polynucleotides comprising unnatural nucleotides
|
|
KR20230107625A
(ko)
|
2020-11-13 |
2023-07-17 |
알닐람 파마슈티칼스 인코포레이티드 |
응고 인자 V(F5) iRNA 조성물 및 이의 사용 방법
|
|
EP4488371A3
(de)
|
2020-11-18 |
2025-04-09 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation der angiotensinogenexpression
|
|
WO2022106695A1
(en)
|
2020-11-23 |
2022-05-27 |
Alpha Anomeric Sas |
Nucleic acid duplexes
|
|
US11987795B2
(en)
|
2020-11-24 |
2024-05-21 |
The Broad Institute, Inc. |
Methods of modulating SLC7A11 pre-mRNA transcripts for diseases and conditions associated with expression of SLC7A11
|
|
EP4256053A1
(de)
|
2020-12-01 |
2023-10-11 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur hemmung der hao1 (hydroxysäureoxidase 1 (glycolatoxidase))-genexpression
|
|
EP4259795A1
(de)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Gerinnungsfaktor x (f10)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
|
MX2023007257A
(es)
|
2020-12-18 |
2023-07-03 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular el factor xii.
|
|
CA3206285A1
(en)
|
2020-12-23 |
2022-06-30 |
Flagship Pioneering, Inc. |
Compositions of modified trems and uses thereof
|
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
CA3210763A1
(en)
|
2021-02-12 |
2022-08-18 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法
|
|
WO2022174102A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
|
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
|
BR112023016645A2
(pt)
|
2021-02-26 |
2023-11-14 |
Alnylam Pharmaceuticals Inc |
Composições de irna de ceto-hexoquinase (khk) e métodos de uso das mesmas
|
|
AU2022231003A1
(en)
|
2021-03-04 |
2023-09-14 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
|
EP4304640A1
(de)
|
2021-03-12 |
2024-01-17 |
Northwestern University |
Antivirale impfstoffe mit kugelförmigen nukleinsäuren
|
|
EP4305169A1
(de)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glykogensynthasekinase-3-alpha (gsk3a)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
CN117203336A
(zh)
|
2021-03-29 |
2023-12-08 |
阿尔尼拉姆医药品有限公司 |
亨廷顿蛋白(HTT)iRNA药剂组合物以及其使用方法
|
|
WO2022212153A1
(en)
|
2021-04-01 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
|
WO2022214632A1
(en)
|
2021-04-07 |
2022-10-13 |
Neoplants Sas |
Compositions and methods for indoor air remediation
|
|
JP2024516164A
(ja)
|
2021-04-22 |
2024-04-12 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
正確なインビボhdr介在性遺伝子編集を可能にするオールインワンデンドリマーベース脂質ナノ粒子
|
|
WO2022231999A1
(en)
|
2021-04-26 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
|
EP4330396A1
(de)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signalwandler und aktivator von transkriptionsfaktor 6 (stat6)-irna-zusammensetzungen und verfahren zur verwendung davon
|
|
EP4334448A1
(de)
|
2021-05-03 |
2024-03-13 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von transthyretin(ttr)-vermittelter amyloidose
|
|
JP2024522068A
(ja)
|
2021-05-18 |
2024-06-11 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ナトリウム-グルコース共輸送体2(sglt2)irna組成物およびその使用方法
|
|
EP4341405A1
(de)
|
2021-05-20 |
2024-03-27 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen für adar-vermittelte bearbeitung
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
JP2024522996A
(ja)
|
2021-06-02 |
2024-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
|
WO2022256538A1
(en)
|
2021-06-03 |
2022-12-08 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
|
|
CN117561334A
(zh)
|
2021-06-04 |
2024-02-13 |
阿尔尼拉姆医药品有限公司 |
人染色体9开放阅读框72(C9ORF72)iRNA药剂组合物和其使用方法
|
|
JP2024523000A
(ja)
|
2021-06-08 |
2024-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
シュタルガルト病及び/又は網膜結合タンパク質4(rbp4)関連障害を治療又は予防するための組成物及び方法
|
|
EP4101928A1
(de)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Programmierbare typ-v-rna-endonukleasesysteme
|
|
CA3222950A1
(en)
|
2021-06-11 |
2022-12-15 |
Bayer Aktiengesellschaft |
Type v rna programmable endonuclease systems
|
|
EP4355759A1
(de)
|
2021-06-18 |
2024-04-24 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur reduzierung der ifnar1-expression
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
US20250034564A1
(en)
|
2021-06-29 |
2025-01-30 |
Korro Bio, Inc. |
Methods and Compositions for ADAR-Mediated Editing
|
|
JP2024527304A
(ja)
|
2021-06-30 |
2024-07-24 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アンジオテンシノーゲン(agt)関連障害を治療するための方法および組成物
|
|
WO2023285431A1
(en)
|
2021-07-12 |
2023-01-19 |
Alia Therapeutics Srl |
Compositions and methods for allele specific treatment of retinitis pigmentosa
|
|
TW202325312A
(zh)
|
2021-07-23 |
2023-07-01 |
美商艾拉倫製藥股份有限公司 |
β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法
|
|
WO2023009687A1
(en)
|
2021-07-29 |
2023-02-02 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
|
JP2024530018A
(ja)
|
2021-08-03 |
2024-08-14 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
トランスサイレチン(TTR)iRNA組成物およびその使用方法
|
|
WO2023014765A1
(en)
|
2021-08-04 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
|
|
BR112024001923A2
(pt)
|
2021-08-13 |
2024-04-30 |
Alnylam Pharmaceuticals Inc |
Composições de irna de fator xii (f12) e métodos de usos das mesmas
|
|
IL311030A
(en)
|
2021-08-31 |
2024-04-01 |
Alnylam Pharmaceuticals Inc |
DFFA-like Cell Death Inducer B (CIDEB) IRNA compositions and methods of using them
|
|
US11833221B2
(en)
|
2021-09-01 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds for reducing DMPK expression
|
|
EP4144841A1
(de)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
|
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
|
CA3232420A1
(en)
|
2021-09-20 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
|
KR20240067943A
(ko)
|
2021-09-24 |
2024-05-17 |
알닐람 파마슈티칼스 인코포레이티드 |
미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법
|
|
KR20240067112A
(ko)
|
2021-09-30 |
2024-05-16 |
아카우오스, 인크. |
Kcnq4-연관 청력손실을 치료하기 위한 조성물 및 방법
|
|
AU2022357561A1
(en)
|
2021-10-01 |
2024-04-18 |
Adarx Pharmaceuticals, Inc. |
Prekallikrein-modulating compositions and methods of use thereof
|
|
EP4419683A1
(de)
|
2021-10-22 |
2024-08-28 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur unterbrechung der nrf2-keap1-proteininteraktion durch adar-vermittelte rna-editierung
|
|
KR20240095325A
(ko)
|
2021-10-29 |
2024-06-25 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 인자 b (cfb) irna 조성물 및 이의 사용 방법
|
|
TW202334418A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
杭丁頓(HTT)iRNA劑組成物及其使用方法
|
|
CA3237770A1
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Antisense oligonucleotides for modifying protein expression
|
|
EP4444881A2
(de)
|
2021-11-10 |
2024-10-16 |
University of Rochester |
Auf gata4 abzielende therapeutika zur behandlung von herzhypertrophie
|
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
|
EP4452327A1
(de)
|
2021-12-20 |
2024-10-30 |
Synthorx, Inc. |
Kopf-hals-krebskombinationstherapie mit einem il-2-konjugat und pembrolizumab
|
|
EP4453196A1
(de)
|
2021-12-21 |
2024-10-30 |
Alia Therapeutics Srl |
Typ-ii-cas-proteine und anwendungen davon
|
|
US20250084391A1
(en)
|
2021-12-23 |
2025-03-13 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
CA3245130A1
(en)
|
2022-03-01 |
2023-09-07 |
Crispr Therapeutics Ag |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISORDERS RELATED TO ANGIOPOIETIN-TYPE PROTEIN 3 (ANGPTL3)
|
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
|
JP2025523400A
(ja)
|
2022-06-10 |
2025-07-23 |
バイエル・アクチエンゲゼルシヤフト |
新規の小型v型rnaプログラム可能エンドヌクレアーゼ系
|
|
EP4573198A2
(de)
|
2022-08-18 |
2025-06-25 |
Alnylam Pharmaceuticals, Inc. |
Universelle nicht-zielgerichtete sirna-zusammensetzungen und verfahren zur verwendung davon
|
|
EP4581143A1
(de)
|
2022-08-29 |
2025-07-09 |
University of Rochester |
Anti-fibrotische therapeutika auf der basis von antisense-oligonukleotiden
|
|
MA71735A
(fr)
|
2022-09-15 |
2025-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions d'arni de 17b-hydroxystéroïde déshydrogénase de type 13 (hsd17b13) et leurs procédés d'utilisation
|
|
WO2024056880A2
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
Enqp type ii cas proteins and applications thereof
|
|
WO2024064858A2
(en)
|
2022-09-23 |
2024-03-28 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing mecp2 expression
|
|
EP4619535A1
(de)
|
2022-11-16 |
2025-09-24 |
Alia Therapeutics Srl |
Typ-ii-cas-proteine und anwendungen davon
|
|
KR20250124839A
(ko)
|
2022-12-13 |
2025-08-20 |
바이엘 악티엔게젤샤프트 |
조작된 제v형 rna 프로그램가능한 엔도뉴클레아제 및 그의 용도
|
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|
|
JP2026503061A
(ja)
|
2023-01-09 |
2026-01-27 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
融合前安定化ヒトパラインフルエンザウイルス3fタンパク質
|
|
CN120882867A
(zh)
|
2023-01-11 |
2025-10-31 |
阿利亚治疗有限公司 |
Ii型cas蛋白及其应用
|
|
WO2024168010A2
(en)
|
2023-02-09 |
2024-08-15 |
Alnylam Pharmaceuticals, Inc. |
Reversir molecules and methods of use thereof
|
|
WO2024170778A1
(en)
|
2023-02-17 |
2024-08-22 |
Anjarium Biosciences Ag |
Methods of making dna molecules and compositions and uses thereof
|
|
EP4683671A1
(de)
|
2023-03-20 |
2026-01-28 |
Synthorx, Inc. |
Krebstherapie mit il-2-peg-konjugaten
|
|
US12383615B2
(en)
|
2023-03-23 |
2025-08-12 |
Carbon Biosciences, Inc. |
Protoparvovirus compositions comprising a protoparvovirus variant VP1 capsid polypeptide and related methods
|
|
WO2024196965A1
(en)
|
2023-03-23 |
2024-09-26 |
Carbon Biosciences, Inc. |
Parvovirus compositions and related methods for gene therapy
|
|
EP4678646A1
(de)
|
2023-04-06 |
2026-01-14 |
Shanghai Argo Biopharmaceutical Co., Ltd. |
Nukleosidanalog zur 5'-phosphonatmodifizierung und daraus hergestelltes oligonukleotid
|
|
CN121285630A
(zh)
|
2023-04-20 |
2026-01-06 |
阿达尔克斯制药有限公司 |
Mapt调节组合物及其使用方法
|
|
WO2024220746A2
(en)
|
2023-04-21 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting fatty acid synthase and related methods
|
|
AU2024273075A1
(en)
|
2023-05-12 |
2025-11-20 |
Adarx Pharmaceuticals, Inc. |
Nmda ligand conjugated compounds and uses thereof
|
|
WO2024243062A1
(en)
|
2023-05-19 |
2024-11-28 |
Streck Llc |
Detection of antibiotic resistance genes
|
|
WO2024249328A2
(en)
|
2023-05-26 |
2024-12-05 |
Adarx Pharmaceuticals, Inc. |
Sod1-modulating compositions and methods of use thereof
|
|
AU2024313301A1
(en)
|
2023-06-20 |
2025-12-11 |
Adarx Pharmaceuticals, Inc. |
Lrrk2-modulating compositions and methods of use thereof
|
|
WO2025003344A1
(en)
|
2023-06-28 |
2025-01-02 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
|
WO2025015335A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2025015338A1
(en)
|
2023-07-13 |
2025-01-16 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2025024334A1
(en)
|
2023-07-21 |
2025-01-30 |
Marrow Therapeutics, Inc. |
Hematopoietic cell targeting conjugates and related methods
|
|
TW202519653A
(zh)
|
2023-07-25 |
2025-05-16 |
美商旗艦先鋒創新有限責任(Vii)公司 |
Cas內切酶及相關方法
|
|
US20250092426A1
(en)
|
2023-07-25 |
2025-03-20 |
Flagship Pioneering Innovations Vii, Llc |
Cas endonucleases and related methods
|
|
WO2025034422A1
(en)
|
2023-08-04 |
2025-02-13 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating ctnnb1-associated disorders
|
|
WO2025059466A1
(en)
|
2023-09-14 |
2025-03-20 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing apociii expression
|
|
US20250215044A1
(en)
|
2023-09-21 |
2025-07-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and Methods for Inhibiting LPA
|
|
WO2025072331A1
(en)
|
2023-09-26 |
2025-04-03 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
GB202314724D0
(en)
|
2023-09-26 |
2023-11-08 |
Astrazeneca Ab |
compounds and methods for reducing psd3 expression
|
|
WO2025072672A2
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Slc6a19-targeting modulatory nucleic acid agents
|
|
WO2025072713A1
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Polymyxins for delivery of agents to the kidney
|
|
WO2025072699A1
(en)
|
2023-09-27 |
2025-04-03 |
Judo Bio, Inc. |
Aminoglycosides for delivery of agents to the kidney
|
|
WO2025076031A2
(en)
|
2023-10-03 |
2025-04-10 |
Alnylam Pharmaceuticals, Inc. |
Peritoneal macrophages comprising a nanoparticle encapsulating a nucleic acid molecule and methods of use thereof
|
|
WO2025076291A1
(en)
|
2023-10-06 |
2025-04-10 |
Bluerock Therapeutics Lp |
Engineered type v rna programmable endonucleases and their uses
|
|
WO2025096809A1
(en)
|
2023-10-31 |
2025-05-08 |
Korro Bio, Inc. |
Oligonucleotides comprising phosphoramidate internucleotide linkages
|
|
WO2025117877A2
(en)
|
2023-12-01 |
2025-06-05 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025128799A1
(en)
|
2023-12-12 |
2025-06-19 |
Korro Bio, Inc. |
Double-stranded rna-editing oligonucleotides and uses thereof
|
|
WO2025158385A1
(en)
|
2024-01-25 |
2025-07-31 |
Genzyme Corporation |
Pegylated il-2 for suppressing adaptive immune response to gene therapy
|
|
WO2025165891A1
(en)
|
2024-01-29 |
2025-08-07 |
Arnatar Therapeutics, Inc |
Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof
|
|
EP4665854A1
(de)
|
2024-01-29 |
2025-12-24 |
Arnatar Therapeutics, Inc |
Translationsverstärkende nukleinsäureverbindungen: aso-gekoppelte translation - hochregulierung 1 (act-up1) und verwendungen davon
|
|
US20250263702A1
(en)
|
2024-02-19 |
2025-08-21 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting cideb and related methods
|
|
US20250313840A1
(en)
|
2024-03-20 |
2025-10-09 |
Vertex Pharmaceuticals Incorporated |
Mucin-5b (muc5b) targeted sirna and antisense oligonucleotides and methods of use thereof
|
|
WO2025207517A2
(en)
|
2024-03-25 |
2025-10-02 |
Synthorx, Inc. |
Synthetic trna synthetases and cells comprising synthetic molecules for production of polypeptides
|
|
GB202404290D0
(en)
|
2024-03-26 |
2024-05-08 |
Senisca Ltd |
Novel oligoncleotides
|
|
WO2025210147A1
(en)
|
2024-04-04 |
2025-10-09 |
Alia Therapeutics Srl |
Type v cas proteins and applications thereof
|
|
WO2025217275A2
(en)
|
2024-04-10 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Immune cell targeted compositions and related methods
|
|
WO2025259743A1
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dual conjugate compounds for extrahepatic delivery
|
|
WO2025259747A2
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
|
|
WO2026006436A1
(en)
|
2024-06-25 |
2026-01-02 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of tar dna binding protein 43 kda (tdp43)
|