SE8802173D0 - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
SE8802173D0
SE8802173D0 SE8802173A SE8802173A SE8802173D0 SE 8802173 D0 SE8802173 D0 SE 8802173D0 SE 8802173 A SE8802173 A SE 8802173A SE 8802173 A SE8802173 A SE 8802173A SE 8802173 D0 SE8802173 D0 SE 8802173D0
Authority
SE
Sweden
Prior art keywords
compounds
chem
och3
ether
formula
Prior art date
Application number
SE8802173A
Other languages
English (en)
Inventor
K N G Johansson
H C G Malmberg
R Noreen
S C Sahlberg
D D Sohn
S Gronowitz
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8802173A priority Critical patent/SE8802173D0/sv
Publication of SE8802173D0 publication Critical patent/SE8802173D0/sv
Priority to CA000601897A priority patent/CA1339313C/en
Priority to DE68926137T priority patent/DE68926137T2/de
Priority to AU37504/89A priority patent/AU637574B2/en
Priority to EP89850184A priority patent/EP0357571B1/en
Priority to ES89850184T priority patent/ES2087090T3/es
Priority to KR1019900700287A priority patent/KR900701815A/ko
Priority to EP95113626A priority patent/EP0691333A2/en
Priority to US07/613,900 priority patent/US5440040A/en
Priority to AT89850184T priority patent/ATE136308T1/de
Priority to JP1506227A priority patent/JP2851094B2/ja
Priority to HU894340A priority patent/HU211736B/hu
Priority to PCT/SE1989/000322 priority patent/WO1989012061A1/en
Priority to PT90803A priority patent/PT90803B/pt
Priority to MYPI89000776A priority patent/MY109743A/en
Priority to PH38770A priority patent/PH27219A/en
Priority to IE181689A priority patent/IE62914B1/en
Priority to NO905300A priority patent/NO175981C/no
Priority to DK291890A priority patent/DK291890A/da
Priority to FI906053A priority patent/FI94643C/sv
Priority to US08/395,877 priority patent/US5576429A/en
Priority to GR960401591T priority patent/GR3020212T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE8802173A 1988-06-10 1988-06-10 Pyrimidine derivatives SE8802173D0 (sv)

Priority Applications (22)

Application Number Priority Date Filing Date Title
SE8802173A SE8802173D0 (sv) 1988-06-10 1988-06-10 Pyrimidine derivatives
CA000601897A CA1339313C (en) 1988-06-10 1989-06-06 Pyrimidine derivatives
PCT/SE1989/000322 WO1989012061A1 (en) 1988-06-10 1989-06-07 Pyrimidine nucleosides and intermediates
JP1506227A JP2851094B2 (ja) 1988-06-10 1989-06-07 ピリミジン誘導体
HU894340A HU211736B (en) 1988-06-10 1989-06-07 Process for preparing pyrimidine nucleosides and pharmaceutical preparations containing them
EP89850184A EP0357571B1 (en) 1988-06-10 1989-06-07 Pyrimidine nucleosides
ES89850184T ES2087090T3 (es) 1988-06-10 1989-06-07 Nucleosidos pirimidinicos.
KR1019900700287A KR900701815A (ko) 1988-06-10 1989-06-07 피리미딘 유도체
EP95113626A EP0691333A2 (en) 1988-06-10 1989-06-07 Pyrimidine derivatives, process for their preparation and their use as precursors
US07/613,900 US5440040A (en) 1988-06-10 1989-06-07 Pyrimidine intermediates
AT89850184T ATE136308T1 (de) 1988-06-10 1989-06-07 Pyrimidin-nukleoside
DE68926137T DE68926137T2 (de) 1988-06-10 1989-06-07 Pyrimidin-Nukleoside
AU37504/89A AU637574B2 (en) 1988-06-10 1989-06-07 Pyrimidine nucleosides and intermediates
PH38770A PH27219A (en) 1988-06-10 1989-06-09 Pyrimidine derivatives
PT90803A PT90803B (pt) 1988-06-10 1989-06-09 Processo para a preparacao de novos derivados de pirimidina
MYPI89000776A MY109743A (en) 1988-06-10 1989-06-09 Pyrimidine derivatives.
IE181689A IE62914B1 (en) 1988-06-10 1989-06-12 Pyrimidine derivatives
NO905300A NO175981C (no) 1988-06-10 1990-12-07 Analogifremgangsmåte ved fremstilling av pyrimidin-nukleosider og mellomprodukter som anvendes deri
DK291890A DK291890A (da) 1988-06-10 1990-12-07 Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf og pyrimidinderivater til anvendelse som mellemprodukter ved fremgangsmaaden samt farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af disse til fremstilling af laegemidler til behandling af aids og infektioner af retrovirus
FI906053A FI94643C (sv) 1988-06-10 1990-12-07 Pyrimidinnukleosider och mellanprodukter
US08/395,877 US5576429A (en) 1988-06-10 1995-02-28 5-substituted pyrimidine nucleosides and nucleotides
GR960401591T GR3020212T3 (en) 1988-06-10 1996-06-12 Pyrimidine nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8802173A SE8802173D0 (sv) 1988-06-10 1988-06-10 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
SE8802173D0 true SE8802173D0 (sv) 1988-06-10

Family

ID=20372582

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802173A SE8802173D0 (sv) 1988-06-10 1988-06-10 Pyrimidine derivatives

Country Status (20)

Country Link
US (2) US5440040A (sv)
EP (2) EP0357571B1 (sv)
JP (1) JP2851094B2 (sv)
KR (1) KR900701815A (sv)
AT (1) ATE136308T1 (sv)
AU (1) AU637574B2 (sv)
CA (1) CA1339313C (sv)
DE (1) DE68926137T2 (sv)
DK (1) DK291890A (sv)
ES (1) ES2087090T3 (sv)
FI (1) FI94643C (sv)
GR (1) GR3020212T3 (sv)
HU (1) HU211736B (sv)
IE (1) IE62914B1 (sv)
MY (1) MY109743A (sv)
NO (1) NO175981C (sv)
PH (1) PH27219A (sv)
PT (1) PT90803B (sv)
SE (1) SE8802173D0 (sv)
WO (1) WO1989012061A1 (sv)

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US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
SE8802173D0 (sv) * 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
CA2297294C (en) * 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5118672A (en) * 1989-07-10 1992-06-02 University Of Georgia Research Foundation 5'-diphosphohexose nucleoside pharmaceutical compositions
FR2656867A1 (fr) * 1990-01-09 1991-07-12 Centre Nat Rech Scient Nouveau derives de la thymidine, leur preparation et les compositions qui les contiennent.
CA2039403A1 (en) * 1990-04-04 1991-10-05 Gerald Saischek Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use
US5128458A (en) * 1990-04-20 1992-07-07 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
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EP0477454A1 (en) * 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
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US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
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CA2122365C (en) * 1991-11-26 2010-05-11 Brian Froehler Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
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US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
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JP3613424B2 (ja) * 1996-09-27 2005-01-26 財団法人国際超電導産業技術研究センター 酸化物超電導体の製造方法
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DE60143672D1 (de) 2000-10-18 2011-01-27 Pharmasset Inc Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation
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US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
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TWI579274B (zh) 2012-04-20 2017-04-21 龍馬躍公司 製備１－芳基－５－烷基吡唑化合物的改良方法
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DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
JPS54112880A (en) * 1978-02-21 1979-09-04 Matsura Teruo Novel uracil derivative and its manufacture
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
HU198393B (en) * 1984-03-06 1989-10-30 Sloan Kettering Inst Cancer Process for production of medical composition suitable for treatment of hepatitis containing as active substance derivatives of piramidin-nucleoside
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
SE8802173D0 (sv) * 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives

Also Published As

Publication number Publication date
PH27219A (en) 1993-05-04
ES2087090T3 (es) 1996-07-16
JPH03504969A (ja) 1991-10-31
EP0357571A2 (en) 1990-03-07
NO905300L (no) 1991-02-06
PT90803B (pt) 1994-10-31
IE62914B1 (en) 1995-03-08
HUT57230A (en) 1991-11-28
EP0357571B1 (en) 1996-04-03
WO1989012061A1 (en) 1989-12-14
DK291890A (da) 1991-02-07
FI94643B (sv) 1995-06-30
FI906053A0 (sv) 1990-12-07
HU211736B (en) 1995-12-28
NO175981C (no) 1995-01-11
AU3750489A (en) 1990-01-05
CA1339313C (en) 1997-08-19
DE68926137T2 (de) 1996-11-14
US5576429A (en) 1996-11-19
EP0691333A3 (sv) 1996-02-14
NO905300D0 (no) 1990-12-07
US5440040A (en) 1995-08-08
KR900701815A (ko) 1990-12-04
MY109743A (en) 1997-05-31
ATE136308T1 (de) 1996-04-15
EP0357571A3 (en) 1990-06-13
PT90803A (pt) 1989-12-29
EP0691333A2 (en) 1996-01-10
JP2851094B2 (ja) 1999-01-27
AU637574B2 (en) 1993-06-03
GR3020212T3 (en) 1996-09-30
HU894340D0 (en) 1991-08-28
FI94643C (sv) 1995-10-10
DK291890D0 (da) 1990-12-07
NO175981B (no) 1994-10-03
DE68926137D1 (de) 1996-05-09
IE891816L (en) 1989-12-10

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