MA54952A - Conjugués d'il-2 et méthodes d'utilisation de ceux-ci - Google Patents

Conjugués d'il-2 et méthodes d'utilisation de ceux-ci

Info

Publication number
MA54952A
MA54952A MA054952A MA54952A MA54952A MA 54952 A MA54952 A MA 54952A MA 054952 A MA054952 A MA 054952A MA 54952 A MA54952 A MA 54952A MA 54952 A MA54952 A MA 54952A
Authority
MA
Morocco
Prior art keywords
conjugates
methods
same
Prior art date
Application number
MA054952A
Other languages
English (en)
Inventor
Carolina E Caffaro
Marcos Milla
Jerod Ptacin
Original Assignee
Synthorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthorx Inc filed Critical Synthorx Inc
Publication of MA54952A publication Critical patent/MA54952A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA054952A 2019-02-06 2020-02-05 Conjugués d'il-2 et méthodes d'utilisation de ceux-ci MA54952A (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962802191P 2019-02-06 2019-02-06
US201962847844P 2019-05-14 2019-05-14
US201962870581P 2019-07-03 2019-07-03
US201962899035P 2019-09-11 2019-09-11
US201962940173P 2019-11-25 2019-11-25

Publications (1)

Publication Number Publication Date
MA54952A true MA54952A (fr) 2022-05-11

Family

ID=71837076

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054952A MA54952A (fr) 2019-02-06 2020-02-05 Conjugués d'il-2 et méthodes d'utilisation de ceux-ci

Country Status (15)

Country Link
US (3) US20200246467A1 (fr)
EP (1) EP3923974A4 (fr)
JP (1) JP2022519271A (fr)
KR (1) KR20210123299A (fr)
CN (2) CN113660946A (fr)
AU (1) AU2020218203A1 (fr)
BR (1) BR112021014415A2 (fr)
CA (1) CA3127689A1 (fr)
CO (1) CO2021009695A2 (fr)
IL (1) IL285285A (fr)
MA (1) MA54952A (fr)
MX (1) MX2021009259A (fr)
SG (1) SG11202107354WA (fr)
TW (1) TW202045208A (fr)
WO (1) WO2020163532A1 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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MX2020008772A (es) 2018-02-26 2020-10-01 Synthorx Inc Conjugados de il-15, y sus usos.
MX2022001776A (es) * 2019-08-15 2022-03-17 Synthorx Inc Terapias de combinacion de inmuno oncologia con conjugados de il-2.
CA3150082A1 (fr) * 2019-09-10 2021-03-18 Jerod PTACIN Conjugues d'il-2 et methodes d'utilisation pour traiter des maladies auto-immunes
CA3162406A1 (fr) 2020-01-10 2021-07-15 Vijaya Raghavan PATTABIRAMAN Polypeptides il-2 modifies et leurs utilisations
CA3176356A1 (fr) 2020-04-22 2021-10-28 Anne BROOKS Systemes et procedes pour coordonner la fabrication de cellules pour l'immunotherapie specifique au patient
CR20220530A (es) 2020-04-22 2022-12-15 Merck Sharp & Dohme Llc CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 ß¿c Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO.
EP4146793A1 (fr) 2020-05-04 2023-03-15 Iovance Biotherapeutics, Inc. Sélection de lymphocytes t réactifs à une tumeur améliorés
EP4146794A1 (fr) 2020-05-04 2023-03-15 Iovance Biotherapeutics, Inc. Procédés de production de lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie
US20220016252A1 (en) * 2020-06-25 2022-01-20 Synthorx, Inc. Immuno oncology combination therapy with il-2 conjugates and anti-egfr antibodies
US20230372397A1 (en) 2020-10-06 2023-11-23 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022076606A1 (fr) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Traitement de patients souffrant de cpnpc avec des thérapies de lymphocytes infiltrant les tumeurs
KR20230084204A (ko) * 2020-10-09 2023-06-12 신톡스, 인크. Il-2 콘쥬게이트를 사용한 면역 종양학 치료법
JP2023546009A (ja) * 2020-10-09 2023-11-01 シンソークス， インコーポレイテッド Ｉｌ－２コンジュゲートおよびペムブロリズマブを用いる免疫腫瘍学併用療法
TW202406932A (zh) * 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
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TW202241508A (zh) 2021-01-29 2022-11-01 美商艾歐凡斯生物治療公司 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
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WO2022174101A1 (fr) * 2021-02-12 2022-08-18 Synthorx, Inc. Polythérapie contre le cancer de la peau à l'aide de conjugués il-2 et de cemiplimab
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TW202313117A (zh) * 2021-06-03 2023-04-01 美商欣爍克斯公司 包含il-2接合物及西妥昔單抗(cetuximab)之頭頸癌組合療法
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JP2024534581A (ja) 2021-09-24 2024-09-20 アイオバンス バイオセラピューティクス，インコーポレイテッド 腫瘍浸潤リンパ球のための拡張プロセス及び薬剤
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WO2023147486A1 (fr) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Lymphocytes infiltrant les tumeurs modifiés pour exprimer des charges utiles
AU2023231217A1 (en) 2022-03-07 2024-10-17 Marielle CHIRON BLONDEL Use of isatuximab in combination with other agents for the treatment of multiple myeloma
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WO2023202035A1 (fr) * 2022-04-20 2023-10-26 北京大学宁波海洋药物研究院 Combinaison de variants d'il-2 pégylés à biais de récepteur et son utilisation
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WO2024055018A1 (fr) 2022-09-09 2024-03-14 Iovance Biotherapeutics, Inc. Procédés de génération de produits til à l'aide d'une double inactivation talen de pd-1/tigit
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WO2024098027A1 (fr) 2022-11-04 2024-05-10 Iovance Biotherapeutics, Inc. Procédés d'expansion de lymphocytes infiltrant les tumeurs (til) liés à la sélection de cd39/cd103
WO2024112571A2 (fr) 2022-11-21 2024-05-30 Iovance Biotherapeutics, Inc. Procédés bidimensionnels pour l'expansion de lymphocytes infiltrant les tumeurs et thérapies associées
WO2024118836A1 (fr) 2022-11-30 2024-06-06 Iovance Biotherapeutics, Inc. Procédés de production de lymphocytes infiltrant les tumeurs à étape rep raccourcie
WO2024136899A1 (fr) * 2022-12-21 2024-06-27 Synthorx, Inc. Thérapie anticancéreuse avec des conjugués d'il-2 et des thérapies par récepteur antigénique chimérique
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US20220016249A1 (en) 2022-01-20
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