MA52284A - Anticorps anti-hla-g et leur utilisation - Google Patents

Anticorps anti-hla-g et leur utilisation

Info

Publication number
MA52284A
MA52284A MA052284A MA52284A MA52284A MA 52284 A MA52284 A MA 52284A MA 052284 A MA052284 A MA 052284A MA 52284 A MA52284 A MA 52284A MA 52284 A MA52284 A MA 52284A
Authority
MA
Morocco
Prior art keywords
hla
antibodies
Prior art date
Application number
MA052284A
Other languages
English (en)
Inventor
Alexander Bujotzek
Stefan Dengl
Sebastian Fenn
Jens Fischer
Andreas Hinz
Sabine Hoves
Claudia Kirstenpfad
Stefan Klostermann
Meher Majety
Joerg Moelleken
Georg Tiefenthaler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA52284A publication Critical patent/MA52284A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA052284A 2018-04-18 2019-04-17 Anticorps anti-hla-g et leur utilisation MA52284A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18168011 2018-04-18

Publications (1)

Publication Number Publication Date
MA52284A true MA52284A (fr) 2021-02-24

Family

ID=62025723

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052284A MA52284A (fr) 2018-04-18 2019-04-17 Anticorps anti-hla-g et leur utilisation

Country Status (21)

Country Link
US (2) US12157770B2 (fr)
EP (1) EP3781593A1 (fr)
JP (1) JP7186239B2 (fr)
KR (1) KR102608672B1 (fr)
CN (1) CN112004831B (fr)
AR (1) AR114789A1 (fr)
AU (1) AU2019254596B2 (fr)
BR (1) BR112020020588A2 (fr)
CA (1) CA3094895A1 (fr)
CL (1) CL2020002540A1 (fr)
CO (1) CO2020012347A2 (fr)
CR (1) CR20200483A (fr)
IL (1) IL277308A (fr)
MA (1) MA52284A (fr)
MX (1) MX2020010951A (fr)
PE (1) PE20201419A1 (fr)
PH (1) PH12020551710A1 (fr)
SG (1) SG11202009695QA (fr)
TW (1) TW201945395A (fr)
WO (1) WO2019202040A1 (fr)
ZA (1) ZA202006066B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
AU2019302454A1 (en) 2018-07-09 2021-02-25 Bristol-Myers Squibb Company Antibodies binding to ILT4
US11208487B2 (en) 2018-09-27 2021-12-28 Tizona Therapeutics Anti-HLA-G antibodies, compositions comprising anti-HLA-G antibodies and methods of using anti-HLA-G antibodies
CN113528448B (zh) * 2020-04-14 2023-01-24 同济大学 一种人胚胎干细胞的构建方法
KR20230005234A (ko) * 2020-04-17 2023-01-09 얀센 바이오테크 인코포레이티드 생합성 당단백질 집단
MX2023007133A (es) 2020-12-17 2023-06-27 Hoffmann La Roche Anticuerpos anti-hla-g y uso de estos.
US12012454B2 (en) * 2021-03-24 2024-06-18 China Medical University Hospital Anti-tumor antigen nanobody and nucleic acid encoding sequence thereof, and uses of the same
GB202111905D0 (en) 2021-08-19 2021-10-06 UCB Biopharma SRL Antibodies
US20250213692A1 (en) * 2022-03-25 2025-07-03 Hk Inno.N Corporation Anti-hla-g chimeric antigen receptor, and use thereof
CN119072495A (zh) * 2022-03-25 2024-12-03 怡诺安有限公司 Hla-g特异性抗体及其用途
CN115894687B (zh) * 2022-03-31 2024-06-07 台州恩泽医疗中心(集团) 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途
WO2024108568A1 (fr) * 2022-11-25 2024-05-30 深圳先进技术研究院 Nanocorps anti-antigène leucocytaire humain g, son procédé de préparation et son utilisation
JP2026508605A (ja) 2023-03-13 2026-03-11 エフ． ホフマン－ラ ロシュ アーゲー 抗ｈｌａ－ｇ／抗ｃｄ３二重特異性抗体及び４－１ｂｂ（ｃｄ１３７）アゴニストを用いたがんの処置
EP4680635A1 (fr) 2023-03-13 2026-01-21 F. Hoffmann-La Roche AG Polythérapie utilisant un anticorps bispécifique pd1-lag3 et un anticorps bispécifique de lymphocytes t hla-g
WO2025054312A1 (fr) * 2023-09-05 2025-03-13 Tizona Therapeutics Anticorps hla-g dans des conjugués anticorps-médicament
WO2025160427A1 (fr) * 2024-01-26 2025-07-31 The Uab Research Foundation Identification d'épitopes hla ciblés par le système immunitaire

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211999B2 (en) 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5770701A (en) 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5606040A (en) 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5750373A (en) 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
CA2026147C (fr) 1989-10-25 2006-02-07 Ravi J. Chari Agents cytotoxiques comprenant des maytansinoides et leur usage therapeutique
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
ES2206447T3 (es) 1991-06-14 2004-05-16 Genentech, Inc. Anticuerpo humanizado para heregulina.
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
WO1993006217A1 (fr) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION DANS L'E. COLI DE FRAGMENTS D'ANTICORPS POSSEDANT AU MOINS UNE CYSTEINE PRESENTE SOUS FORME D'UN THIOL LIBRE, ET LEUR UTILISATION DANS LA PRODUCTION D'ANTICORPS BIFONCTIONNELS F(ab')¿2?
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
WO1993008829A1 (fr) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
EP0625200B1 (fr) 1992-02-06 2005-05-11 Chiron Corporation Proteine de liaison biosynthetique pour marqueur de cancer
PL174494B1 (pl) 1992-11-13 1998-08-31 Idec Pharma Corp Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
ES2246069T3 (es) 1997-05-02 2006-02-01 Genentech, Inc. Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
ATE531812T1 (de) 1997-12-05 2011-11-15 Scripps Research Inst Humanisierung von nager-antikörpern
EP1054688B1 (fr) 1998-02-20 2004-06-30 Commissariat A L'energie Atomique Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications
ES2267275T3 (es) 1998-07-10 2007-03-01 Connex Gmbh Reactivo inmunologico que interacciona especificamente con el dominio extracelular de la cadena zeta humana.
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
NZ517906A (en) 1999-10-04 2003-01-31 Medicago Inc Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
AU784983B2 (en) 1999-12-15 2006-08-17 Genentech Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
CA2395660A1 (fr) 1999-12-29 2001-07-12 Immunogen, Inc. Agents cytotoxiques comprenant des doxorubicines et des daunorubicines modifiees et utilisation therapeutique de ceux-ci
LT2857516T (lt) 2000-04-11 2017-09-11 Genentech, Inc. Multivalentiniai antikūnai ir jų panaudojimas
CA2425186A1 (fr) 2000-09-15 2002-03-21 University Of Kansas Medical Center Expression, preparation, utilisations et sequence de la proteine hla-g soluble derivee par recombinaison
WO2002034290A2 (fr) 2000-10-23 2002-05-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps et autres ligands dirige contre le recepteur de kir2dl4 pour la production de l'interferon gamma
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CA2430013C (fr) 2000-11-30 2011-11-22 Medarex, Inc. Rongeurs transgeniques et transchromosomiques pour la fabrication d'anticorps humains
AU2003239966B9 (en) 2002-06-03 2010-08-26 Genentech, Inc. Synthetic antibody phage libraries
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
CN103833854B (zh) 2002-12-16 2017-12-12 健泰科生物技术公司 免疫球蛋白变体及其用途
EP1585767A2 (fr) 2003-01-16 2005-10-19 Genentech, Inc. Banques de phages anticorps synthetiques
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
EP1629012B1 (fr) 2003-05-31 2018-11-28 Amgen Research (Munich) GmbH Compositions pharmaceutiques comprenant des constructions d'anticorps anti-cd3, anti-cd19 bispecifiques pour le traitement de troubles associes aux lymphocytes b
FR2856599A1 (fr) 2003-06-30 2004-12-31 Commissariat Energie Atomique Utilisation de compositions contenant une forme soluble d'hla-g dans le traitement de pathologies du sang.
US9175064B2 (en) 2003-11-04 2015-11-03 Shuji Miyagawa HLA-E chimeric molecule
NZ583292A (en) 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
NZ550217A (en) 2004-03-31 2009-11-27 Genentech Inc Humanized anti-TGF-beta antibodies
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
EP2357201B1 (fr) 2004-04-13 2017-08-30 F. Hoffmann-La Roche AG Anticorps dirigés contre la sélectine P
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ｏｘ４０ｌ抗體
EP1791565B1 (fr) 2004-09-23 2016-04-20 Genentech, Inc. Anticorps et conjugues produits avec de la cysteine
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
CN1312182C (zh) 2004-10-26 2007-04-25 四川新创生物科技有限公司 抗hla－g的单克隆抗体及分泌它的杂交瘤细胞株、癌症诊断试剂盒及其应用
TWI544076B (zh) 2005-03-31 2016-08-01 中外製藥股份有限公司 A method of manufacturing a polypeptide that controls assembly
WO2007042261A2 (fr) 2005-10-11 2007-04-19 Micromet Ag Compositions comportant des anticorps specifiques d'especes croisees et leurs utilisations
EP2465870A1 (fr) 2005-11-07 2012-06-20 Genentech, Inc. Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
EP1973951A2 (fr) 2005-12-02 2008-10-01 Genentech, Inc. Polypeptides de liaison avec des sequences de diversite limitees
PL1999154T3 (pl) 2006-03-24 2013-03-29 Merck Patent Gmbh Skonstruowane metodami inżynierii heterodimeryczne domeny białkowe
AR060871A1 (es) 2006-05-09 2008-07-16 Genentech Inc Union de polipeptidos con supercontigos optimizados
JP2009541275A (ja) 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス 二重特異性抗体の生産
US20080044455A1 (en) 2006-08-21 2008-02-21 Chaim Welczer Tonsillitus Treatment
ES2399075T3 (es) 2006-08-30 2013-03-25 Genentech, Inc. Anticuerpos multiespecíficos
SG195609A1 (en) 2007-04-03 2013-12-30 Amgen Res Munich Gmbh Cross-species-specific binding domain
CN100592373C (zh) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 液晶显示面板驱动装置及其驱动方法
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8592562B2 (en) 2008-01-07 2013-11-26 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
JP5501439B2 (ja) 2009-04-02 2014-05-21 ロシュ グリクアート アクチェンゲゼルシャフト 完全長抗体と単鎖Ｆａｂフラグメントとを含む多重特異的抗体
SG175077A1 (en) 2009-04-07 2011-11-28 Roche Glycart Ag Trivalent, bispecific antibodies
EP3505636A1 (fr) 2009-04-27 2019-07-03 OncoMed Pharmaceuticals, Inc. Procédé de fabrication de molécules hétéromultimères
TW201100543A (en) 2009-05-27 2011-01-01 Hoffmann La Roche Tri-or tetraspecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
EP2264067A1 (fr) 2009-06-18 2010-12-22 Hla-G Technologies Multimères de HLA-G alpha 1 et leurs utilisations pharmaceutiques
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
ES2515241T3 (es) 2009-06-25 2014-10-29 Commissariat à l'énergie atomique et aux énergies alternatives Polipéptidos multímeros de HLA-G que incluyen al menos dos dominios alfa3 y usos farmacéuticos de los mismos
CN101967191A (zh) 2009-07-28 2011-02-09 广州天美生物技术有限公司 Hla-g抗体制备方法及其在医学中的应用
SG10201408401RA (en) 2009-09-16 2015-01-29 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
US20130089554A1 (en) 2009-12-29 2013-04-11 Emergent Product Development Seattle, Llc RON Binding Constructs and Methods of Use Thereof
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
US9527926B2 (en) 2010-05-14 2016-12-27 Rinat Neuroscience Corp. Heterodimeric proteins and methods for producing and purifying them
EA034742B1 (ru) 2010-08-13 2020-03-16 Роше Гликарт Аг Антитела к fap, полинуклеотид, вектор и клетка для их получения и их применения
WO2012025530A1 (fr) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Anticorps bispécifiques comprenant un fragment fv stabilisé par bisulfure
WO2012025525A1 (fr) 2010-08-24 2012-03-01 Roche Glycart Ag Anticorps bispécifiques activables
CN105497883A (zh) 2010-09-29 2016-04-20 乌第有限合伙公司 使用生物相容性的生物可吸收纳米球治疗自身免疫病的方法
CA2815266C (fr) 2010-11-05 2023-09-05 Zymeworks Inc. Conception d'anticorps heterodimerique stable ayant des mutations dans le domaine fc
ES2659764T3 (es) 2011-08-23 2018-03-19 Roche Glycart Ag Moléculas biespecíficas de unión a antígeno activadoras de linfocitos T
KR101886983B1 (ko) 2011-08-23 2018-08-08 로슈 글리카트 아게 2 개의 ｆａｂ 단편을 포함하는 fc-부재 항체 및 이용 방법
BR112014004168A2 (pt) 2011-08-23 2017-12-12 Roche Glycart Ag anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção
HUE039703T2 (hu) 2011-08-23 2019-01-28 Roche Glycart Ag Bispecifikus antigénkötõ molekulák
SG11201401518TA (en) 2011-10-28 2014-05-29 Teva Pharmaceuticals Australia Pty Ltd Polypeptide constructs and uses thereof
SI2794905T1 (sl) 2011-12-20 2020-08-31 Medimmune, Llc Modificirani polipeptidi za ogrodja bispecifičnega protitelesa
US20130177574A1 (en) 2012-01-11 2013-07-11 Paul I. Terasaki Foundation Laboratory ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE
ES2676031T3 (es) 2012-02-15 2018-07-16 F. Hoffmann-La Roche Ag Cromatografía de afinidad basada en el receptor Fc
CN107383197B (zh) 2012-04-20 2021-12-10 美勒斯公司 用于产生免疫球蛋白样分子的方法和手段
WO2013164325A1 (fr) 2012-05-02 2013-11-07 F. Hoffmann-La Roche Ag Protéines de liaison à un antigène multispécifiques
CN104379604A (zh) 2012-05-24 2015-02-25 弗·哈夫曼-拉罗切有限公司 多特异性抗体
RU2015101699A (ru) 2012-06-21 2016-08-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Слитые полипептиды и конъюгаты полипептида лиганда рецептора инкретина и fc-области с измененной fc-эффекторной функцией
EP2730588A1 (fr) 2012-11-12 2014-05-14 Intelectys Anticorps et fragments de ceux-ci dirigés contre le domaine alpha-3 de protéine HLA-G, procédés et moyens pour leur préparation et leurs utilisations
MX384246B (es) 2013-10-30 2025-03-14 Genzyme Corp POLIPÉPTIDO DE UNIÓN A TCR ALFA BETA PARA USARSE EN LA DISMINUCIÓN DE LINFOCITOS TAß.
KR102597804B1 (ko) 2013-12-20 2023-11-07 제넨테크, 인크. 이중 특이적 항체
US20160152725A1 (en) * 2014-02-25 2016-06-02 Memorial Sloan-Kettering Cancer Center Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide
TW202330606A (zh) * 2014-03-21 2023-08-01 美商艾伯維有限公司 抗-egfr抗體及抗體藥物結合物
UA117289C2 (uk) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
MX370788B (es) 2014-04-03 2020-01-06 Cellectis Receptores de antígeno quimérico específico de cd33 para inmunoterapia de cáncer.
CN106573986A (zh) 2014-07-29 2017-04-19 豪夫迈·罗氏有限公司 多特异性抗体
SI3608337T1 (sl) 2014-08-04 2024-07-31 F. Hoffmann - La Roche Ag Biospecifične molekule za aktivacijo celic T in antigensko vezavo
JO3664B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme أجسام مضادة لـ tigit
TWI751102B (zh) * 2014-08-28 2022-01-01 美商奇諾治療有限公司 對ｃｄ１９具專一性之抗體及嵌合抗原受體
BR112017005451A2 (pt) 2014-10-24 2018-01-02 Hoffmann La Roche anticorpo humanizado e métodos para a seleção de um ou mais fragmentos fv de anticorpo variantes e para a produção de um anticorpo
CN107207591A (zh) 2014-12-10 2017-09-26 豪夫迈·罗氏有限公司 血脑屏障受体抗体及使用方法
US20190119385A1 (en) 2015-03-27 2019-04-25 University Of Southern California Hla-g as a novel target for car t-cell immunotherapy
CA2980189A1 (fr) 2015-04-24 2016-10-27 Genentech, Inc. Proteines multispecifiques de liaison a l'antigene
KR20180054877A (ko) 2015-10-07 2018-05-24 에프. 호프만-라 로슈 아게 공자극 tnf 수용체에 대해 4가를 갖는 이중특이적 항체
CN109563169B (zh) * 2016-06-03 2022-07-01 英韦克泰斯公司 抗hla-g特异性抗体
TW201811752A (zh) * 2016-09-06 2018-04-01 比利時商健生藥品公司 用作升糖素受體拮抗劑之吲唑衍生物
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
CN109314396B (zh) 2017-04-07 2022-07-19 Oppo广东移动通信有限公司 无线充电系统、装置、方法及待充电设备
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
AR115052A1 (es) 2018-04-18 2020-11-25 Hoffmann La Roche Anticuerpos multiespecíficos y utilización de los mismos
WO2020043899A1 (fr) 2018-08-31 2020-03-05 Invectys Récepteurs d'antigènes chimériques contre de multiples isoformes de hla-g
SG11202105093RA (en) 2018-12-21 2021-06-29 Hoffmann La Roche Tumor-targeted agonistic cd28 antigen binding molecules
MX2023007133A (es) 2020-12-17 2023-06-27 Hoffmann La Roche Anticuerpos anti-hla-g y uso de estos.

Also Published As

Publication number Publication date
JP7186239B2 (ja) 2022-12-08
CN112004831B (zh) 2024-04-09
WO2019202040A1 (fr) 2019-10-24
CO2020012347A2 (es) 2020-10-30
US12157770B2 (en) 2024-12-03
AU2019254596A1 (en) 2020-10-29
KR20210005080A (ko) 2021-01-13
CL2020002540A1 (es) 2021-01-22
EP3781593A1 (fr) 2021-02-24
AR114789A1 (es) 2020-10-14
ZA202006066B (en) 2021-09-29
CN112004831A (zh) 2020-11-27
CA3094895A1 (fr) 2019-10-24
US20250051456A1 (en) 2025-02-13
TW201945395A (zh) 2019-12-01
JP2021521791A (ja) 2021-08-30
MX2020010951A (es) 2020-11-09
BR112020020588A2 (pt) 2021-01-12
PH12020551710A1 (en) 2023-01-30
SG11202009695QA (en) 2020-11-27
KR102608672B1 (ko) 2023-11-30
US20210147553A1 (en) 2021-05-20
CR20200483A (es) 2020-11-17
PE20201419A1 (es) 2020-12-09
IL277308A (en) 2020-10-29
AU2019254596B2 (en) 2025-10-16

Similar Documents

Publication Publication Date Title
MA52284A (fr) Anticorps anti-hla-g et leur utilisation
EP3904386A4 (fr) Anticorps et son utilisation
EP3797124A4 (fr) Anticorps anti-ro1 et son utilisation
MA52285A (fr) Anticorps multispécifiques et leur utilisation
EP3802612A4 (fr) Anticorps anti-b7-h3 et son utilisation
MA47311A (fr) Anticorps anti-tgf-bêta et leur utilisation
EP3887403A4 (fr) Anticorps anti-4-1bb et son utilisation
EP3448412A4 (fr) Anticorps anti-vista humain et leur utilisation
EP3907240A4 (fr) Anticorps anti-tnfr2 et son utilisation
EP3962956A4 (fr) Anticorps anti-hvem et leur utilisation
EP3442567A4 (fr) Anticorps anti-psma et leur utilisation
EP3572427A4 (fr) Anticorps ciblant bcma et son utilisation
EP3875484A4 (fr) Anticorps ciblant cll1 et son utilisation
EP3626825A4 (fr) Anticorps anti-cdh6 et conjugué anticorps anti-cdh6-médicament
EP3604338A4 (fr) Anticorps anti-ox40 et utilisation correspondante
EP3575318A4 (fr) Anticorps anti-pd-1 et son utilisation
EP4039705A4 (fr) Anticorps ciblant bcma, anticorps bispécifique et leur utilisation
EP3599249A4 (fr) Conjugué anticorps anti-5t4-médicament et son utilisation
EP4045537A4 (fr) Anticorps ciblant les flt3 et leur utilisation
MA50038A (fr) Anticorps anti-pd-l1 de et son utilisation
EP3819313A4 (fr) Anticorps bispécifique et son utilisation
EP3630844A4 (fr) Nouvel anticorps anti-c-met et son utilisation
EP3733705A4 (fr) Anticorps monoclonaux et procédés de leur utilisation
EP4082570A4 (fr) Anticorps anti-ctla-4 et son utilisation
EP3632933A4 (fr) Nouveaux anticorps anti-cd40 et leur utilisation