NZ525921A - Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications - Google Patents

Info

Publication number

NZ525921A

NZ525921A NZ525921A NZ52592102A NZ525921A NZ 525921 A NZ525921 A NZ 525921A NZ 525921 A NZ525921 A NZ 525921A NZ 52592102 A NZ52592102 A NZ 52592102A NZ 525921 A NZ525921 A NZ 525921A

Authority

NZ

New Zealand

Prior art keywords

alkyl

group

substituted

aryl

independently selected

Prior art date

2001-01-26

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• 235000003702 sterols Nutrition 0.000 title claims abstract description 126
• 150000003432 sterols Chemical class 0.000 title claims abstract description 124
• 238000010521 absorption reaction Methods 0.000 title claims abstract description 88
• 239000012190 activator Substances 0.000 title claims abstract description 71
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title claims abstract description 52
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title claims abstract description 52
• 230000002792 vascular Effects 0.000 title claims abstract description 35
• 238000011282 treatment Methods 0.000 title claims description 65
• 239000000203 mixture Substances 0.000 claims abstract description 220
• 230000001225 therapeutic effect Effects 0.000 claims abstract description 73
• 238000000034 method Methods 0.000 claims abstract description 39
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• 235000020824 obesity Nutrition 0.000 claims abstract description 36
• MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 claims abstract description 30
• 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 29
• 125000000217 alkyl group Chemical group 0.000 claims description 628
• -1 fatty acid esters Chemical class 0.000 claims description 250
• 125000003118 aryl group Chemical group 0.000 claims description 244
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• 150000001875 compounds Chemical class 0.000 claims description 218
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 179
• 150000003839 salts Chemical class 0.000 claims description 133
• 239000001257 hydrogen Substances 0.000 claims description 131
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• 125000005843 halogen group Chemical class 0.000 claims description 104
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 76
• 125000001072 heteroaryl group Chemical class 0.000 claims description 72
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• 229910052736 halogen Inorganic materials 0.000 claims description 37
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• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 25
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• YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims description 17
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• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 15
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• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 14
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• YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical group C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 13
• WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims description 13
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• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 13
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 13
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• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 13
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• ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical group OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 claims description 12
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 12
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