GB1415295A - Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof - Google Patents

Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Info

Publication number
GB1415295A
GB1415295A GB4792771A GB4792771A GB1415295A GB 1415295 A GB1415295 A GB 1415295A GB 4792771 A GB4792771 A GB 4792771A GB 4792771 A GB4792771 A GB 4792771A GB 1415295 A GB1415295 A GB 1415295A
Authority
GB
United Kingdom
Prior art keywords
alkyl
halo
alkoxy
agents
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4792771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchimed SA
Original Assignee
Orchimed SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2003430A priority Critical patent/DE2003430C3/en
Application filed by Orchimed SA filed Critical Orchimed SA
Priority to GB4792771A priority patent/GB1415295A/en
Priority to FR7236165A priority patent/FR2157853B2/fr
Priority to BE790026D priority patent/BE790026R/en
Priority to DE2250327A priority patent/DE2250327C2/en
Publication of GB1415295A publication Critical patent/GB1415295A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Abstract

1415295 Phenoxyalkyl-carboxylic acid derivatives ORCHIMED SA 16 Oct 1972 [14 Oct 1971 (2)] 47926/71 and 47927/71 Heading C2C Novel compounds I (in which R<SP>II</SP> and R<SP>V</SP> are H, CH 3 , C 2 H 5 , C 6 H 5 , p-chlorophenyl or p-fluorophenyl; R<SP>III</SP> and R<SP>IIII</SP> are H, halo, 1-5C alkyl, CF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 , OCH 3 , OH, C 6 H 5 or substituted phenyl; R<SP>VI</SP> is H, 1-5 C alkyl, aryl-optionally substituted by CH 3 , CF 3 or halo-, cycloalkyl, OH, 1-6 C alkoxy, optionally substituted aryloxy, cycloalkoxy, cycloalkenyloxy, NR 3 R 4 , NHCH 2 CH 2 NR 3 R 4 or -O-alkylene-NR 3 R 4 ; Y<SP>1</SP> is OH, 1-4C alkoxy, -NR 3 R 4 , or -O-alkylene-NR 3 R 4 ; X<SP>1</SP> is O or -NORO ; R 0 is H, 1-5C, -CH 2 CH 2 NR 3 R 4 or and R 3 and R 4 are H, 1-5C alkyl, 3-7C cycloalkyl or aryl optionally substituted by halo, CH 3 and/or CF 3 ; or NR 3 R 4 is a 5-7 membered heterocyclic ring, optionally containing a further heteroatom selected from O, S and N, or is -NH(CH 2 ) 4 CH(NH 2 )COOH or -NHCH(COOH)CH 2 SH; with the provisos that (i) if R<SP>III</SP> and R<SP>IIII</SP> are not both H, then R<SP>VI</SP> is CH 3 or p-chlorophenyl and (ii) if Y<SP>1</SP> is OH or alkoxy, R<SP>VI</SP> is H or 1-5 C alkyl and one of R<SP>II</SP> and R<SP>V</SP> is H, then the other of R<SP>II</SP> and R<SP>V</SP> is CH 3 or C 2 H 5 ) are prepared by conventional chemical processes. Compounds claimed in Specification 1,268,321 are specifically disclaimed. 4 - Hydroxy - 41 i chlorobenzophenone is prepared by reaction of phenol with p-chlorobenzoyl chloride in the presence of AlCl 3 . Ethyl p-carboxyphenoxyacetate is prepared by reaction of ethyl bromoacetate with p-hydroxybenzoic acid. Pharmaceutical compositions useful as analgesics, anti-inflammatory agents, psychotropic agents, cardiovascular agents, anti-tussive agents, normolipemiants and hypocholesterolemiants comprise a compound I together with a suitable diluent or carrier.
GB4792771A 1969-01-31 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof Expired GB1415295A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE2003430A DE2003430C3 (en) 1969-01-31 1970-01-27 p-Benzoylphenoxyisobutyric acid esters, their preparation and pharmaceuticals containing them
GB4792771A GB1415295A (en) 1971-10-14 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof
FR7236165A FR2157853B2 (en) 1971-10-14 1972-10-12
BE790026D BE790026R (en) 1969-01-31 1972-10-13 PROCESS FOR PREPARATION OF BODIES DERIVED FROM ACID
DE2250327A DE2250327C2 (en) 1969-01-31 1972-10-13 Phenoxyibutyric acid derivatives, their acid addition salts, processes for their preparation and pharmaceutical agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4792771A GB1415295A (en) 1971-10-14 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof
GB4792671 1971-10-14

Publications (1)

Publication Number Publication Date
GB1415295A true GB1415295A (en) 1975-11-26

Family

ID=26266167

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4792771A Expired GB1415295A (en) 1969-01-31 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Country Status (2)

Country Link
FR (1) FR2157853B2 (en)
GB (1) GB1415295A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242358A (en) * 1979-01-24 1980-12-30 Societe De Recherches Industrielles (Sori) Method of treatment of algiae
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4853404A (en) * 1986-10-13 1989-08-01 Tanabe Seiyaku Co., Ltd. Phenoxyacetic acid derivatives composition and use
US6013839A (en) * 1996-02-15 2000-01-11 Rhone-Poulenc Agriculture Limited Process for preparing 2-(thiosubstituted)-4-haloacetophenones
WO2006135480A2 (en) * 2005-04-08 2006-12-21 Abbott Laboratories Oral pharmaceutical formulations comprising fenofibric acid and/or its salts
US7732413B2 (en) 2003-03-07 2010-06-08 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7741289B2 (en) 2003-03-07 2010-06-22 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US20100185008A1 (en) * 2007-07-05 2010-07-22 Finorga Method for Producing Fenofibrate
WO2012055014A1 (en) 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
CN107261149A (en) * 2008-12-04 2017-10-20 于崇曦 High-penetration composition and its application
WO2021019493A1 (en) 2019-07-31 2021-02-04 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1517603A (en) * 1976-04-02 1978-07-12 Lafon Labor Esters of 2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl-propionic acid with bis-(hydroxyalkylthio)-alkanes
GB1520602A (en) * 1976-04-02 1978-08-09 Lafon Labor Esters of bis-(hydroxyalkylthio)-alkanes
GB2024209B (en) * 1978-05-31 1982-09-08 Sori Soc Rech Ind Phenoxalkylcarboxylic acids
FR2494112B1 (en) * 1980-11-19 1986-01-10 Laruelle Claude
FR2886844B1 (en) * 2005-06-09 2007-09-14 Oreal USE OF 2-OXY-ACETAMIDE COMPOUNDS FOR PROMOTING AND / OR INDUCING AND / OR STIMULATING THE PIGMENTATION OF KERATINIC MATERIALS AND / OR LIMITING THEIR DEPIGMENTATION AND / OR BLEACHING
FR2918367A1 (en) * 2007-07-05 2009-01-09 Finorga Soc Par Actions Simpli Preparation of fenofibrate from fenofibric acid comprises preparing fenofibric acid chloride by action of thionyl chloride on the fenofibric acid, in situ, then reacting isopropanol without isolation of acid chloride
FR2918662B1 (en) * 2007-07-10 2009-10-30 Finorga Soc Par Actions Simpli PROCESS FOR THE PREPARATION OF FENOFIBRATE
EP4180036A4 (en) 2020-09-29 2024-01-31 Laboratorios Silanes S A De C V Pharmaceutical combinations of statins and fibrates for the treatment and prevention of hyperlipidaemia and cardiovascular diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3379755A (en) * 1964-06-04 1968-04-23 Merck & Co Inc Preparation of (4-alkanoylphenoxy) acetic acids by oxidation
FR4963M (en) * 1965-09-15 1967-05-08
CH528101A (en) * 1970-03-11 1972-09-15 Ciba Geigy Ag Use of 2-hydroxybenzophenones as a stabilizer against ultraviolet radiation in color photographic material

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242358A (en) * 1979-01-24 1980-12-30 Societe De Recherches Industrielles (Sori) Method of treatment of algiae
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4853404A (en) * 1986-10-13 1989-08-01 Tanabe Seiyaku Co., Ltd. Phenoxyacetic acid derivatives composition and use
US6013839A (en) * 1996-02-15 2000-01-11 Rhone-Poulenc Agriculture Limited Process for preparing 2-(thiosubstituted)-4-haloacetophenones
US7732413B2 (en) 2003-03-07 2010-06-08 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7741289B2 (en) 2003-03-07 2010-06-22 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EA023376B1 (en) * 2005-04-08 2016-05-31 Эббот Лабораториз Solid dosage form and package containing the same for combined therapy
NO343548B1 (en) * 2005-04-08 2019-04-01 Bgp Products Ireland Ltd Pharmaceutical formulations
WO2006135480A3 (en) * 2005-04-08 2007-04-05 Abbott Lab Oral pharmaceutical formulations comprising fenofibric acid and/or its salts
NO20075628L (en) * 2005-04-08 2007-11-05 Bgp Products Ireland Ltd Pharmaceutical formulations
WO2006135480A2 (en) * 2005-04-08 2006-12-21 Abbott Laboratories Oral pharmaceutical formulations comprising fenofibric acid and/or its salts
US20100185008A1 (en) * 2007-07-05 2010-07-22 Finorga Method for Producing Fenofibrate
CN111808011B (en) * 2008-12-04 2024-02-27 泰飞尔生物医药(苏州)有限公司 High penetration composition and its application
US11541029B2 (en) 2008-12-04 2023-01-03 Techfields Pharma Co., Ltd. High penetration compositions and their applications
CN113636965A (en) * 2008-12-04 2021-11-12 于崇曦 High penetration composition and application thereof
CN108191846B (en) * 2008-12-04 2021-08-20 于崇曦 High penetration composition and application thereof
CN107261149A (en) * 2008-12-04 2017-10-20 于崇曦 High-penetration composition and its application
CN111808011A (en) * 2008-12-04 2020-10-23 于崇曦 High penetration composition and application thereof
CN108191846A (en) * 2008-12-04 2018-06-22 于崇曦 High-penetration composition and its application
EA022988B1 (en) * 2010-10-27 2016-04-29 Прометик Биосайнсиз Инк. Phenylketone carboxylate compounds and pharmaceutical uses thereof
KR101870468B1 (en) 2010-10-27 2018-06-22 프로메틱 파마 에스엠티 리미티드 Phenylketone carboxylate compounds and pharmaceutical uses thereof
US9475750B2 (en) 2010-10-27 2016-10-25 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
EA022988B9 (en) * 2010-10-27 2016-08-31 Прометик Биосайнсиз Инк. Phenylketone carboxylate compounds and pharmaceutical uses thereof
KR20130140745A (en) * 2010-10-27 2013-12-24 프로메틱 바이오사이언시즈 인코포레이티드 Phenylketone carboxylate compounds and pharmaceutical uses thereof
WO2012055014A1 (en) 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
WO2021019493A1 (en) 2019-07-31 2021-02-04 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate
EP4115879A1 (en) 2019-07-31 2023-01-11 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate

Also Published As

Publication number Publication date
FR2157853A2 (en) 1973-06-08
FR2157853B2 (en) 1975-11-28

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Legal Events

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PS Patent sealed
PE20 Patent expired after termination of 20 years