ES376688A1 - Benzdiazepine derivatives - Google Patents
Benzdiazepine derivativesInfo
- Publication number
- ES376688A1 ES376688A1 ES376688A ES376688A ES376688A1 ES 376688 A1 ES376688 A1 ES 376688A1 ES 376688 A ES376688 A ES 376688A ES 376688 A ES376688 A ES 376688A ES 376688 A1 ES376688 A1 ES 376688A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- coo
- cooh
- halogen
- benzdiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Abstract
Compounds of the general formula (R=H, C 1-4 alkyl, C 3-4 alkenyl, PhCH 2 , - CH 2 COOH, -(CH 2 ) 2 COOH, -CH 2 COO(C 1-3 alkyl), -CH 2 CH 2 COO(C 1-3 alkyl), -(CH 2 ) 2-3 - N(C 1-3 alkyl) 2 , C 4-5 alkyleneiminoethyl, C 4-5 alkyleneiminopropyl R 1 = H, CH 3 , halogen, NO 2 , CN, CF 3 R 2 =H, halogen) and their acid addition salts are prepared by condensing a compound of the formula or the corresponding 2-m.ethylthio-5-phenyl- 3H-1,4-benzodiazepine with H 2 NOR or a salt thereof, optionally followed by salt formation. The above compounds are sedatives and tranquillizers, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80345069A | 1969-02-28 | 1969-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES376688A1 true ES376688A1 (en) | 1972-05-01 |
Family
ID=25186534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES376688A Expired ES376688A1 (en) | 1969-02-28 | 1970-02-18 | Benzdiazepine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS4810799B1 (en) |
| BE (1) | BE746664A (en) |
| BR (1) | BR6915069D0 (en) |
| CH (1) | CH535773A (en) |
| DE (1) | DE2005176A1 (en) |
| DK (1) | DK131567C (en) |
| ES (1) | ES376688A1 (en) |
| FR (1) | FR2034577B1 (en) |
| GB (1) | GB1243953A (en) |
| IL (1) | IL33735A (en) |
| NL (1) | NL7002712A (en) |
| SE (1) | SE367631B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3649617A (en) * | 1970-07-20 | 1972-03-14 | Upjohn Co | 2-substituted amino-5-phenyl-3h-1 4-benzodiazepines |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| GB9911152D0 (en) * | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| ATE480532T1 (en) | 2006-07-10 | 2010-09-15 | Paion Uk Ltd | BENZODIAZEPINE SALTS WITH SHORT-TERM ACTION AND POLYMORPHOUS FORMS THEREOF |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| AR094963A1 (en) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | EXCELLENT OXIDATION REACTION IN THE CONVERSION INDEX |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB956592A (en) * | 1960-04-20 | 1964-04-29 | Smith Kline French Lab | Improvements in or relating to trifluoromethyl-1,4-benzodiazepine derivatives |
-
1969
- 1969-12-12 BR BR215069/69A patent/BR6915069D0/en unknown
-
1970
- 1970-01-15 GB GB2094/70A patent/GB1243953A/en not_active Expired
- 1970-01-19 IL IL33735A patent/IL33735A/en unknown
- 1970-02-05 DE DE19702005176 patent/DE2005176A1/en active Pending
- 1970-02-10 SE SE01674/70A patent/SE367631B/xx unknown
- 1970-02-17 JP JP45013151A patent/JPS4810799B1/ja active Pending
- 1970-02-18 ES ES376688A patent/ES376688A1/en not_active Expired
- 1970-02-26 NL NL7002712A patent/NL7002712A/xx not_active Application Discontinuation
- 1970-02-27 CH CH295370A patent/CH535773A/en not_active IP Right Cessation
- 1970-02-27 BE BE746664D patent/BE746664A/en not_active IP Right Cessation
- 1970-02-27 DK DK100670A patent/DK131567C/en active
- 1970-02-27 FR FR707007282A patent/FR2034577B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2034577B1 (en) | 1973-07-13 |
| BE746664A (en) | 1970-08-27 |
| IL33735A (en) | 1972-12-29 |
| BR6915069D0 (en) | 1973-08-16 |
| GB1243953A (en) | 1971-08-25 |
| CH535773A (en) | 1973-04-15 |
| DK131567B (en) | 1975-08-04 |
| FR2034577A1 (en) | 1970-12-11 |
| DE2005176A1 (en) | 1970-09-10 |
| DK131567C (en) | 1976-03-01 |
| IL33735A0 (en) | 1970-03-22 |
| NL7002712A (en) | 1970-09-01 |
| SE367631B (en) | 1974-06-04 |
| JPS4810799B1 (en) | 1973-04-07 |
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