ES8101585A1 - Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico - Google Patents

Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Info

Publication number
ES8101585A1
ES8101585A1 ES488665A ES488665A ES8101585A1 ES 8101585 A1 ES8101585 A1 ES 8101585A1 ES 488665 A ES488665 A ES 488665A ES 488665 A ES488665 A ES 488665A ES 8101585 A1 ES8101585 A1 ES 8101585A1
Authority
ES
Spain
Prior art keywords
hyperlipoproteinaemia
isobutyrate
para
hypolipaemic
hypocholesterolaemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488665A
Other languages
English (en)
Other versions
ES488665A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES488665A priority Critical patent/ES488665A0/es
Priority to FR8017235A priority patent/FR2476095A1/fr
Priority to BE2/58700A priority patent/BE884722A/fr
Publication of ES8101585A1 publication Critical patent/ES8101585A1/es
Publication of ES488665A0 publication Critical patent/ES488665A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 2-P-CLOROFENOXIISOBUTIRATO-1,3-DINICOTINATO DE TRIHIDROXIPROPANO. CONSISTE EN HACER REACCIONAR EN REACCION DE ESTERIFICACION, DEL ACIDO P-CLOROFENOXIISOBUTIRICO CON EL 1,3-DIHALOGENO-2-PROPANOL, EN UN MEDIO DISOLVENTE INERTE (TAL COMO BENZOL, TOLUOL O XILOL). EN LA REACCION SE EMPLEAN CATALIZADORES Y MEDIOS DE CAPTACION DEL AGUA PRODUCIDA EN LA REACCION. SE OBTIENE EL COMPUESTO 2,P-CLORO-FENOXIISOBUTIRATO DE 1''.3''-DIHALOGENO-ISOPROPILO, QUE SE HACE REACCIOANR CON LA SAL NICOTINICA DE UN METAL ALCALINO. SE OBTIENE UN COMPUESTO DE FORMULA ESTRUCTURAL (I). *FORMULA* TRATAMIENTO DE HIPERLIPEMIAS E HIPERCOLESTEROLEMIAS PRIMARIA O SECUNDARIA. PREVENCION DE ARTERIOSCLEROSIS.
ES488665A 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico Granted ES488665A0 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES488665A ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico
FR8017235A FR2476095A1 (en) 1980-02-15 1980-08-01 Glyceryl 2-para-chloro:phenoxy-isobutyrate-1,3-di:nicotinate - hypolipaemic and hypocholesterolaemic used to treat atherosclerosis, hyperlipoproteinaemia and high tri:glyceride plasma levels
BE2/58700A BE884722A (fr) 1980-02-15 1980-08-12 Nouvel ester mixte symetrique de 1,2,3-trihydroxypropane, son procede d'obtention et ses applications therapeutiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES488665A ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Publications (2)

Publication Number Publication Date
ES8101585A1 true ES8101585A1 (es) 1980-12-16
ES488665A0 ES488665A0 (es) 1980-12-16

Family

ID=8479833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488665A Granted ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Country Status (3)

Country Link
BE (1) BE884722A (es)
ES (1) ES488665A0 (es)
FR (1) FR2476095A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692262B1 (fr) * 1992-06-10 1994-08-05 Adir Nouveaux nicotinates de diacylglycerols, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
ATE406364T1 (de) 2003-03-07 2008-09-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
ES2318274T3 (es) 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
PE20180027A1 (es) 2015-02-06 2018-01-09 Intercept Pharmaceuticals Inc Composiciones farmaceuticas para terapia combinada
BR112021024109A2 (pt) 2019-05-30 2022-03-22 Intercept Pharmaceuticals Inc Composições farmacêuticas compreendendo um agonista fxr e um fibrato para uso no tratamento de doença hepática colestática

Also Published As

Publication number Publication date
FR2476095A1 (en) 1981-08-21
ES488665A0 (es) 1980-12-16
BE884722A (fr) 1980-12-01
FR2476095B1 (es) 1984-03-09

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 19991217