HUP9800964A2 - O- és S-tartalmú 6 tagú benzo-kondenzált heterociklusos vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények - Google Patents

O- és S-tartalmú 6 tagú benzo-kondenzált heterociklusos vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9800964A2
HUP9800964A2 HU9800964A HUP9800964A HUP9800964A2 HU P9800964 A2 HUP9800964 A2 HU P9800964A2 HU 9800964 A HU9800964 A HU 9800964A HU P9800964 A HUP9800964 A HU P9800964A HU P9800964 A2 HUP9800964 A2 HU P9800964A2
Authority
HU
Hungary
Prior art keywords
general formula
pipe
preparation
heterocyclic compounds
fused heterocyclic
Prior art date
Application number
HU9800964A
Other languages
English (en)
Inventor
Isabelle Charton
Philippe Delagrange
Béatrice Guardiola
Gérald Guillaumet
Ahmed Mamai
Bruno Pfeiffer
Pierre Renard
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU9800964D0 publication Critical patent/HU9800964D0/hu
Publication of HUP9800964A2 publication Critical patent/HUP9800964A2/hu
Publication of HUP9800964A3 publication Critical patent/HUP9800964A3/hu
Publication of HU223468B1 publication Critical patent/HU223468B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

A találmány szerinti (I) általánős képletű vegyületek - a képletben X és Y jelentése azőnősan vagy eltérően kénatőm, őxigéantőm, CHqáltalánős képletű csőpőrt (ahől q értékre 0, 1 vagy 2) SO vagy SO2csőpőrt, azzal a megkötéssel, hőgy X és Y egyidejűleg jelenthet CHqáltalánős képletű csőpőrt, (amelyben q értéke 0, 1 vagy 2), Z jelentése őxigénatőm, vagy CH2 csőpőrt, n értéke 0, 1, 2, 3 vagy 4, A jelentése (a) általánős képletű csőpőrt, vagy (b) általánős képletűcsőpőrt, R jelentése hidrőgénatőm, adőtt esetben szűbsztitűált, 1-6 szénatőmősalkilcsőpőrt, arilcsőpőrt vagy aril-alkil-csőpőrt, és gyógyászatilagelfőgadható savakkal vagy bázisőkkal alkőtőtt sóikgyógyszerkészítmények hatóanyagaként a melatőninerg rendszerrendellenességeivel kapcsőlatős betegségek kezelésére alkalmazhatók.(I) (a) (b) ŕ
HU9800964A 1997-04-25 1998-04-24 O- és S-tartalmú 6 tagú benzo-kondenzált heterociklusos vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények HU223468B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9705110A FR2762598A1 (fr) 1997-04-25 1997-04-25 Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent

Publications (4)

Publication Number Publication Date
HU9800964D0 HU9800964D0 (en) 1998-06-29
HUP9800964A2 true HUP9800964A2 (hu) 2000-05-28
HUP9800964A3 HUP9800964A3 (en) 2000-06-28
HU223468B1 HU223468B1 (hu) 2004-07-28

Family

ID=9506306

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800964A HU223468B1 (hu) 1997-04-25 1998-04-24 O- és S-tartalmú 6 tagú benzo-kondenzált heterociklusos vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények

Country Status (19)

Country Link
US (1) US5919814A (hu)
EP (1) EP0873993B1 (hu)
JP (1) JP4125418B2 (hu)
CN (1) CN1145622C (hu)
AT (1) ATE213496T1 (hu)
AU (1) AU736716B2 (hu)
BR (1) BR9801448B1 (hu)
CA (1) CA2235421C (hu)
DE (1) DE69803894T2 (hu)
DK (1) DK0873993T3 (hu)
ES (1) ES2173556T3 (hu)
FR (1) FR2762598A1 (hu)
HK (1) HK1014956A1 (hu)
HU (1) HU223468B1 (hu)
NO (1) NO317742B1 (hu)
NZ (1) NZ330279A (hu)
PL (1) PL198572B1 (hu)
PT (1) PT873993E (hu)
ZA (1) ZA983490B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548708A1 (de) * 1995-12-23 1997-06-26 Merck Patent Gmbh Cyclische Sulfone
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805993B1 (fr) * 2000-03-08 2004-01-16 Adir Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement du developpement de la tolerance aux composes nitres
US6750213B2 (en) 2000-10-19 2004-06-15 Merck & Co., Inc. Estrogen receptor modulators
AU2002221269A1 (en) * 2000-10-19 2002-04-29 Merck & Co., Inc. Estrogen receptor modulators
KR100904566B1 (ko) * 2001-10-04 2009-06-25 슈프레스타 엘엘씨 올리고머 히드록시-말단 포스포네이트 및 이를 포함하는 조성물
JP4554219B2 (ja) 2002-04-24 2010-09-29 メルク・シャープ・エンド・ドーム・コーポレイション エストロゲン受容体調節剤
FR2918372B1 (fr) * 2007-07-02 2009-08-28 Servier Lab Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2918370B1 (fr) * 2007-07-02 2009-08-28 Servier Lab Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2716680B1 (fr) * 1994-02-25 1996-04-05 Adir Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
BR9801448B1 (pt) 2009-01-13
ZA983490B (en) 1998-10-29
CN1145622C (zh) 2004-04-14
JP4125418B2 (ja) 2008-07-30
PL325989A1 (en) 1998-10-26
NZ330279A (en) 1998-11-25
NO981814L (no) 1998-10-26
JPH10298178A (ja) 1998-11-10
HK1014956A1 (en) 1999-10-08
HUP9800964A3 (en) 2000-06-28
EP0873993B1 (fr) 2002-02-20
AU6359198A (en) 1998-10-29
FR2762598A1 (fr) 1998-10-30
NO317742B1 (no) 2004-12-13
HU9800964D0 (en) 1998-06-29
NO981814D0 (no) 1998-04-22
ES2173556T3 (es) 2002-10-16
HU223468B1 (hu) 2004-07-28
CN1197797A (zh) 1998-11-04
CA2235421A1 (fr) 1998-10-25
CA2235421C (fr) 2003-09-16
EP0873993A1 (fr) 1998-10-28
ATE213496T1 (de) 2002-03-15
BR9801448A (pt) 2000-02-08
PL198572B1 (pl) 2008-06-30
DK0873993T3 (da) 2002-06-10
PT873993E (pt) 2002-07-31
AU736716B2 (en) 2001-08-02
DE69803894D1 (de) 2002-03-28
DE69803894T2 (de) 2002-11-07
US5919814A (en) 1999-07-06

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