IT1244699B - Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione - Google Patents

Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione

Info

Publication number
IT1244699B
IT1244699B ITMI910255A ITMI910255A IT1244699B IT 1244699 B IT1244699 B IT 1244699B IT MI910255 A ITMI910255 A IT MI910255A IT MI910255 A ITMI910255 A IT MI910255A IT 1244699 B IT1244699 B IT 1244699B
Authority
IT
Italy
Prior art keywords
preparation
azetidinone
carbamoyloxy
acylamino
intermediates
Prior art date
Application number
ITMI910255A
Other languages
English (en)
Inventor
Giuseppe Guanti
Luca Banfi
Enrica Narisano
Renata Riva
Elso Manghisi
Giuseppe Cascio
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to ITMI910255A priority Critical patent/IT1244699B/it
Publication of ITMI910255A0 publication Critical patent/ITMI910255A0/it
Priority to PCT/EP1992/000175 priority patent/WO1992013837A1/en
Priority to AU11873/92A priority patent/AU1187392A/en
Publication of ITMI910255A1 publication Critical patent/ITMI910255A1/it
Application granted granted Critical
Publication of IT1244699B publication Critical patent/IT1244699B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

E' descritto un processo per la preparazione di monobattami di formula (FORMULA I) (ove R = acile) e dei loro sali farmaceuticamente accettabili, a partire da esteri dell'acido (R) malico, attraverso l'intermedio di reazione (3S, 4S) 3-idrazino-4-idrossimetil-2-azetidinone, che costituisce un ulteriore oggetto dell'invenzione. Questa riguarda inoltre la conversione del (3S, 4S) 3-(benzilossicarbonil)ammino-4-idrossimetil-2-azetidinone e del (3S, 4S) 3-(t -butossicarbonil)ammino-4-idrossimetil-2-azetidinone rispettivamente nel (3S, 4S) 3-(benzilossicarbonil)ammino-4-(carbamoilossi)-2-azetidinone e nel (3S, 4S) 3-(t -butossicarbonil)ammino-4-(carbamoilossi)-2-azetidinone.
ITMI910255A 1991-02-01 1991-02-01 Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione IT1244699B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI910255A IT1244699B (it) 1991-02-01 1991-02-01 Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione
PCT/EP1992/000175 WO1992013837A1 (en) 1991-02-01 1992-01-28 A process for the preparation of 3-acylamino-4-carbamoyloxymethyl-2-azetidinone-1-sulphonic acids and intermediates for the preparation thereof
AU11873/92A AU1187392A (en) 1991-02-01 1992-01-28 A process for the preparation of 3-acylamino-4-carbamoyloxymethyl-2-azetidinone-1-sulphonic acids and intermediates for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910255A IT1244699B (it) 1991-02-01 1991-02-01 Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione

Publications (3)

Publication Number Publication Date
ITMI910255A0 ITMI910255A0 (it) 1991-02-01
ITMI910255A1 ITMI910255A1 (it) 1992-08-01
IT1244699B true IT1244699B (it) 1994-08-08

Family

ID=11358378

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910255A IT1244699B (it) 1991-02-01 1991-02-01 Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione

Country Status (3)

Country Link
AU (1) AU1187392A (it)
IT (1) IT1244699B (it)
WO (1) WO1992013837A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
JP4711600B2 (ja) 2001-01-26 2011-06-29 シェーリング コーポレイション シトステロール血症の処置のための置換アゼチジノン化合物の使用
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN100439361C (zh) 2003-03-07 2008-12-03 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
US4502994A (en) * 1982-12-09 1985-03-05 Hoffmann-La Roche Inc. Enantiomeric synthesis of 3-amino-4-carbamoyloxymethyl-2-azetidonone-1-sulfate
IT1231770B (it) * 1989-08-02 1991-12-21 Consiglio Nazionale Ricerche Processo per la preparazione di monobattami ed intermedio di preparazione.

Also Published As

Publication number Publication date
ITMI910255A1 (it) 1992-08-01
WO1992013837A1 (en) 1992-08-20
ITMI910255A0 (it) 1991-02-01
AU1187392A (en) 1992-09-07

Similar Documents

Publication Publication Date Title
IT1244699B (it) Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione
DK172751B1 (da) Cis,endo-2-azabicyclo[3,3,0]octan-3-carboxylsyrer og estere deraf samt salte deraf og fremgangsmåde til deres fremstilling
DE3587674T2 (de) Perhydrothiazepinderivate, ihre Herstellung und ihre therapeutische Verwendung.
NO176274C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten
DK0462531T3 (da) Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme
DE69809962D1 (de) Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen
EA200000057A1 (ru) (+)-норцисаприд, пригодный для лечения нарушений, опосредованных 5-нт3 и 5-нт4 (рецепторами)
ES2129671T3 (es) Sintesis de aminoacidos a partir de acidos carboxilicos y lactamas.
NO165073C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive 6-hydroxyalkyl-2-(substituert)thio-penem-3-carboxylsyrer
Georg et al. N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes
Bose et al. HojiH zyxwvuts
Matsuura et al. Efficient synthesis of mugineic acid, a typical phytosiderophore, utilizing the phenyl group as the carboxyl synthon
KR970002469B1 (en) Aminoacid ester process for their manufacture and their use
Crimmin et al. Synthesis of phenolically linked cyclic peptides
EP1193253A4 (en) METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE AZETIDIN-2-CARBOXYLIC ACIDS
ATE37371T1 (de) Verfahren zur herstellung asymmetrischer hydantoine.
NO955112L (no) Fremgangsmåte for fremstilling av oksazolidinkarboksylsyre samt anvendelse derav for fremstiling av terapeutisk aktive taxoider
AU8294401A (en) A process for the preparation of alpha' chloroketones
RO93483B (ro) Procedeu pentru prepararea acidului [3s(z)]-2-[[[1-(2-amino-4-tiazolil)-2-[[2,2-dimetil-4-oxo-1-(sulfooxi)-3-oxoetiliden]amino]oxi]acetic
Fernández-Suárez et al. Asymmetric synthesis of the β-amino acid methyl ester derivative of onchidin:(2S, 3S)-methyl-3-amino-2-methyl-7-octynoate and its enantiomer
NO955253L (no) Nye fremgangsmåter for fremstilling av (S)-4-amino-hepta-5,6-diensyre og mellomprodukter derav
TH13281A (th) ขบวนการสำหรับการผลิตไซคลิคเอสเทอร์จากกรดไฮดรอกซีและอนุพันธุ์ของสารนี้
EP0280285A3 (en) Process for making and isolating (r)-2-hydroxy 4-phenylbutyric acid and esters
Mori et al. Absolute configuration of(+)-xanthocidin as determined by the synthesis of its enantiomers of known stereochemistry
GB1467407A (en) Process for the manufacture of 7-beta-acylaminoceph-3-em- 4-carboxylic acid compounds

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226