TR200904500A2 - Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları. - Google Patents

Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları.

Info

Publication number
TR200904500A2
TR200904500A2 TR2009/04500A TR200904500A TR200904500A2 TR 200904500 A2 TR200904500 A2 TR 200904500A2 TR 2009/04500 A TR2009/04500 A TR 2009/04500A TR 200904500 A TR200904500 A TR 200904500A TR 200904500 A2 TR200904500 A2 TR 200904500A2
Authority
TR
Turkey
Prior art keywords
ezetimibe
nanocrystals
preparation
methods
pharmaceutical formulations
Prior art date
Application number
TR2009/04500A
Other languages
English (en)
Inventor
Öner Levent
Gülsün Tuğba
Nesli̇han Gürsoy Reyhan
Original Assignee
Öner Levent
Nesli̇han Gürsoy Reyhan
Gülsün Tuğba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Öner Levent, Nesli̇han Gürsoy Reyhan, Gülsün Tuğba filed Critical Öner Levent
Priority to TR2009/04500A priority Critical patent/TR200904500A2/tr
Publication of TR200904500A2 publication Critical patent/TR200904500A2/tr
Priority to PCT/TR2010/000106 priority patent/WO2010144066A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Abstract

Mevcut buluş, ezetimib veya famıasötik olarak uygun bır tuzunun nanokristallerinin hazırlanması için bir yöntem ve bu yöntemle hazırlanan nanokristalleri içeren ezetimib farmasötik formülasyonları ve hazırlanması ile ilgilidir.
TR2009/04500A 2009-06-10 2009-06-10 Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları. TR200904500A2 (tr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TR2009/04500A TR200904500A2 (tr) 2009-06-10 2009-06-10 Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları.
PCT/TR2010/000106 WO2010144066A1 (en) 2009-06-10 2010-06-04 Method for the preparation of ezetimib nanocrystals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2009/04500A TR200904500A2 (tr) 2009-06-10 2009-06-10 Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları.

Publications (1)

Publication Number Publication Date
TR200904500A2 true TR200904500A2 (tr) 2009-10-21

Family

ID=42740287

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2009/04500A TR200904500A2 (tr) 2009-06-10 2009-06-10 Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları.

Country Status (2)

Country Link
TR (1) TR200904500A2 (tr)
WO (1) WO2010144066A1 (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
JP2014511867A (ja) * 2011-04-18 2014-05-19 合肥貝霓医薬科技有限公司 ジヒドロピリジン系カルシウムチャネルブロッカーの精製、及びそのナノ粒子の調製方法
CN103655481A (zh) * 2012-09-18 2014-03-26 江苏柯菲平医药有限公司 一种依折麦布口服制剂制备方法

Family Cites Families (21)

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US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US6375986B1 (en) 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
US20020115696A1 (en) 1999-06-18 2002-08-22 Yoel Kloog Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists
US20040115134A1 (en) 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
SI1353696T1 (sl) 2001-01-26 2007-04-30 Schering Corp Kombinacije aktivatorja(-ev) peroksisomskega proliferatorja aktivirajocega receptorja (PPAR) in inhibitorja(-ev) absorpcije sterola in oblike zdravljenja za vaskularne indikacije
AU2003230692A1 (en) 2002-03-20 2003-10-08 Elan Pharma International Ltd. Nanoparticulate compositions of map kinase inhibitors
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
CA2488499C (en) 2002-06-10 2013-03-19 Elan Pharma International Ltd. Nanoparticulate formulations comprising hmg coa reductase inhibitor derivatives ("statins"),combinations thereof as well as manufacturing of these pharmaceutical compositions
EA200501001A1 (ru) 2002-12-31 2005-12-29 Нектар Терапьютикс Фармацевтический состав с нерастворимым активным агентом
BRPI0512326A (pt) 2004-06-21 2008-02-26 Nektar Therapeutics composições compreendendo anfotericina b, métodos e sistemas
US20060160785A1 (en) * 2004-12-03 2006-07-20 Judith Aronhime Ezetimibe polymorphs
CA2604770C (en) * 2005-04-13 2013-09-24 Abbott Gmbh & Co. Kg Method for carefully producing ultrafine particle suspensions and ultrafine particles and use thereof
US20060234996A1 (en) 2005-04-14 2006-10-19 Itai Adin Novel crystalline form of ezetimibe and processes for the preparation thereof
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US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
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WO2008092057A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Formulation process method to produce spray dried products
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Also Published As

Publication number Publication date
WO2010144066A1 (en) 2010-12-16

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