EA201590752A1 - Препараты производных пиримидиндиона - Google Patents

Препараты производных пиримидиндиона

Info

Publication number
EA201590752A1
EA201590752A1 EA201590752A EA201590752A EA201590752A1 EA 201590752 A1 EA201590752 A1 EA 201590752A1 EA 201590752 A EA201590752 A EA 201590752A EA 201590752 A EA201590752 A EA 201590752A EA 201590752 A1 EA201590752 A1 EA 201590752A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyramidindion
derivatives
methods
pharmaceutical compositions
preparations
Prior art date
Application number
EA201590752A
Other languages
English (en)
Other versions
EA028481B1 (ru
Inventor
Янься Ли
Пин Гао
И Ши
Хао Хоу
Майкл Мэкэплоу
Келли Э. Мидоуз
Джефф Дж. Чжан
И Гао
Original Assignee
Эббви Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эббви Инк. filed Critical Эббви Инк.
Publication of EA201590752A1 publication Critical patent/EA201590752A1/ru
Publication of EA028481B1 publication Critical patent/EA028481B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к фармацевтическим композициям производных пиримидиндиона и к способам их получения и применения. Изобретение также относится к способам повышения биодоступности производных пиримидиндиона в фармацевтических композициях, вводимых субъекту, и к способам уменьшения количества производного пиримидиндиона в фармацевтических композициях с получением такой же биодоступности у субъекта.
EA201590752A 2012-10-18 2013-10-18 Препараты производных пиримидиндиона EA028481B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261715766P 2012-10-18 2012-10-18
PCT/US2013/065760 WO2014063101A1 (en) 2012-10-18 2013-10-18 Formulations of pyrimidinedione derivative compounds

Publications (2)

Publication Number Publication Date
EA201590752A1 true EA201590752A1 (ru) 2016-02-29
EA028481B1 EA028481B1 (ru) 2017-11-30

Family

ID=49554481

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590752A EA028481B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона
EA201791354A EA032913B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201791354A EA032913B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона

Country Status (11)

Country Link
US (2) US9629841B2 (ru)
EP (1) EP2908808A1 (ru)
JP (2) JP6266635B2 (ru)
CN (2) CN104853752B (ru)
AU (1) AU2013330993B2 (ru)
BR (1) BR112015008927A2 (ru)
CA (1) CA2888883A1 (ru)
EA (2) EA028481B1 (ru)
MX (1) MX2015004973A (ru)
SG (1) SG11201503051QA (ru)
WO (1) WO2014063101A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
CN115605186A (zh) * 2020-03-05 2023-01-13 奥瑞基尼探索技术有限公司（In） 激酶抑制剂的药物组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4442257A1 (de) * 1994-11-28 1996-05-30 Beate Dr Podschun Sparsomycin
BR9910481A (pt) 1998-06-11 2001-01-09 Upjohn Co Composição farmacêutica para comprimido de liberação não-contìnua
CA2395331C (en) 1999-12-23 2009-01-06 Pfizer Products Inc. Pharmaceutical compositions providing enhanced drug concentrations
GB0009522D0 (en) * 2000-04-19 2000-06-07 Smithkline Beecham Plc Composition
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
CA2590675A1 (en) * 2004-12-15 2006-06-22 Elan Pharma International Ltd. Nanoparticulate tacrolimus formulations
US20070082952A1 (en) * 2005-10-06 2007-04-12 Benjamin Eric J Pharmaceutical compositions, methods of preparation thereof, and methods of treatment
PT2368882E (pt) * 2007-09-17 2014-11-27 Abbvie Bahamas Ltd Pirimidinas anti-infecciosas e seus usos
CN102746239B (zh) * 2007-09-17 2016-02-10 艾伯维巴哈马有限公司 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物
US20100166861A1 (en) * 2008-12-29 2010-07-01 Kelly Noel Lynch Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone
CA2790707A1 (en) * 2010-03-01 2011-09-09 Concert Pharmaceuticals Inc. Fluorouracil derivatives
AU2013201532B2 (en) * 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV

Also Published As

Publication number Publication date
BR112015008927A2 (pt) 2017-07-04
SG11201503051QA (en) 2015-05-28
AU2013330993A1 (en) 2015-05-07
JP2015534985A (ja) 2015-12-07
JP2018065858A (ja) 2018-04-26
MX2015004973A (es) 2015-07-17
EP2908808A1 (en) 2015-08-26
US9629841B2 (en) 2017-04-25
US10201542B2 (en) 2019-02-12
EA201791354A3 (ru) 2018-03-30
US20140113921A1 (en) 2014-04-24
WO2014063101A1 (en) 2014-04-24
EA032913B1 (ru) 2019-08-30
CA2888883A1 (en) 2014-04-24
CN104853752B (zh) 2018-10-23
EA201791354A2 (ru) 2017-11-30
CN109260207A (zh) 2019-01-25
JP6266635B2 (ja) 2018-01-24
EA028481B1 (ru) 2017-11-30
CN104853752A (zh) 2015-08-19
AU2013330993B2 (en) 2018-03-01
US20170181973A1 (en) 2017-06-29

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU