EA201791354A3 - Препараты производных пиримидиндиона - Google Patents

Препараты производных пиримидиндиона

Info

Publication number
EA201791354A3
EA201791354A3 EA201791354A EA201791354A EA201791354A3 EA 201791354 A3 EA201791354 A3 EA 201791354A3 EA 201791354 A EA201791354 A EA 201791354A EA 201791354 A EA201791354 A EA 201791354A EA 201791354 A3 EA201791354 A3 EA 201791354A3
Authority
EA
Eurasian Patent Office
Prior art keywords
pyramidindion
derivatives
methods
pharmaceutical compositions
preparations
Prior art date
Application number
EA201791354A
Other languages
English (en)
Other versions
EA032913B1 (ru
EA201791354A2 (ru
Inventor
Янься Ли
Пин Гао
И Ши
Хао Хоу
Майкл Мэкэплоу
Келли Э. Мидоуз
Джефф Дж. Чжан
И Гао
Original Assignee
Эббви Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эббви Инк. filed Critical Эббви Инк.
Publication of EA201791354A2 publication Critical patent/EA201791354A2/ru
Publication of EA201791354A3 publication Critical patent/EA201791354A3/ru
Publication of EA032913B1 publication Critical patent/EA032913B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к фармацевтическим композициям производных пиримидиндиона и к способам их получения и применения. Настоящее изобретение также относится к способам повышения биодоступности производных пиримидиндиона в фармацевтических композициях, вводимых субъекту, и к способам уменьшения количества производного пиримидиндиона в фармацевтических композициях с получением такой же биодоступности у субъекта.
EA201791354A 2012-10-18 2013-10-18 Препараты производных пиримидиндиона EA032913B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261715766P 2012-10-18 2012-10-18

Publications (3)

Publication Number Publication Date
EA201791354A2 EA201791354A2 (ru) 2017-11-30
EA201791354A3 true EA201791354A3 (ru) 2018-03-30
EA032913B1 EA032913B1 (ru) 2019-08-30

Family

ID=49554481

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590752A EA028481B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона
EA201791354A EA032913B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201590752A EA028481B1 (ru) 2012-10-18 2013-10-18 Препараты производных пиримидиндиона

Country Status (11)

Country Link
US (2) US9629841B2 (ru)
EP (1) EP2908808A1 (ru)
JP (2) JP6266635B2 (ru)
CN (2) CN109260207A (ru)
AU (1) AU2013330993B2 (ru)
BR (1) BR112015008927A2 (ru)
CA (1) CA2888883A1 (ru)
EA (2) EA028481B1 (ru)
MX (1) MX2015004973A (ru)
SG (1) SG11201503051QA (ru)
WO (1) WO2014063101A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
MX2022011058A (es) * 2020-03-05 2022-12-13 Aurigene Discovery Tech Ltd Composiciones farmaceuticas de un inhibidor de cinasa.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4442257A1 (de) * 1994-11-28 1996-05-30 Beate Dr Podschun Sparsomycin
JP4827296B2 (ja) 1998-06-11 2011-11-30 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー デラビルジン錠製剤
EP1712222A3 (en) 1999-12-23 2012-06-20 Pfizer Products Inc. Pharmaceutical compositions providing enhanced drug concentrations
GB0009522D0 (en) * 2000-04-19 2000-06-07 Smithkline Beecham Plc Composition
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US20060159766A1 (en) * 2004-12-15 2006-07-20 Elan Pharma International Limited Nanoparticulate tacrolimus formulations
WO2007044574A2 (en) * 2005-10-06 2007-04-19 Transtech Pharma, Inc. Pharmaceutical compositions, methods of preparation thereof, and methods of treatment
CN104628654A (zh) * 2007-09-17 2015-05-20 艾伯维巴哈马有限公司 抗感染嘧啶及其用途
WO2009039127A1 (en) * 2007-09-17 2009-03-26 Abbott Laboratories Uracil or thymine derivative for treating hepatitis c
US20100166861A1 (en) * 2008-12-29 2010-07-01 Kelly Noel Lynch Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone
WO2011109274A1 (en) * 2010-03-01 2011-09-09 Concert Pharmaceuticals Inc. Fluorouracil derivatives
ES2527544T1 (es) * 2011-10-21 2015-01-26 Abbvie Inc. Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC

Also Published As

Publication number Publication date
JP2015534985A (ja) 2015-12-07
CA2888883A1 (en) 2014-04-24
US9629841B2 (en) 2017-04-25
BR112015008927A2 (pt) 2017-07-04
AU2013330993B2 (en) 2018-03-01
EA028481B1 (ru) 2017-11-30
EA032913B1 (ru) 2019-08-30
EA201590752A1 (ru) 2016-02-29
EA201791354A2 (ru) 2017-11-30
SG11201503051QA (en) 2015-05-28
MX2015004973A (es) 2015-07-17
CN104853752A (zh) 2015-08-19
US10201542B2 (en) 2019-02-12
US20170181973A1 (en) 2017-06-29
WO2014063101A1 (en) 2014-04-24
JP6266635B2 (ja) 2018-01-24
US20140113921A1 (en) 2014-04-24
JP2018065858A (ja) 2018-04-26
CN104853752B (zh) 2018-10-23
AU2013330993A1 (en) 2015-05-07
EP2908808A1 (en) 2015-08-26
CN109260207A (zh) 2019-01-25

Similar Documents

Publication Publication Date Title
EA201590931A1 (ru) Гетероциклические замещенные производные 2-амино-хиназолина для лечения вирусных инфекций
CY1123953T1 (el) Καθυστερημενης απελευθερωσης συνθεσεις λινακλοτιδης
EA201992133A1 (ru) Производные пиперидино-пиримидина для лечения вирусных инфекций
CY1118379T1 (el) Αναστολεις ιου ηπατιτιδας c
EA201391719A1 (ru) Хиназолиновые производные для лечения вирусных инфекций и дальнейших заболеваний
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
EA201590343A1 (ru) Алкилпиримидиновые производные для лечения вирусных инфекций и дальнейших заболеваний
UA113651C2 (xx) Макроциклічні пурини для лікування вірусних інфекцій
EA201591195A1 (ru) Новые хинолоновые производные
EA201692301A1 (ru) Производные бороновой кислоты и их терапевтическое применение
EA201690303A1 (ru) ПРОИЗВОДНЫЕ ТИЕНО[3,2-d]ПИРИМИДИНОВ ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ
EA201591003A1 (ru) Производные бороновой кислоты и их терапевтическое применение
MX2015008627A (es) Derivados de acido boronico y usos terapeuticos de los mismos.
EA201590667A1 (ru) Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний
EA201490947A1 (ru) Производные пурина для лечения вирусных инфекций
EA202090547A2 (ru) Макроциклические деаза-оксипурины для лечения вирусных инфекций
EA202090662A3 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ
EA202090258A2 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ
PH12014502540A1 (en) Benzimidazole-proline derivatives
BR112016008576A2 (pt) Formulações aquosas estáveis de anticorpos e forma farmacêutica de dosagem unitária
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
EA201790032A1 (ru) Бициклически замещённые урацилы и их применение
EA201500628A1 (ru) Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов
EA201600434A1 (ru) Применение производных бензимидазолпролина
EA201300034A1 (ru) Фармацевтические композиции, содержащие иматиниб или его фармацевтически приемлемую соль, и способы их получения

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU