JP4110140B2 - チロシンキナーゼの阻害剤 - Google Patents

チロシンキナーゼの阻害剤 Download PDF

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Publication number
JP4110140B2
JP4110140B2 JP2004518718A JP2004518718A JP4110140B2 JP 4110140 B2 JP4110140 B2 JP 4110140B2 JP 2004518718 A JP2004518718 A JP 2004518718A JP 2004518718 A JP2004518718 A JP 2004518718A JP 4110140 B2 JP4110140 B2 JP 4110140B2
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JP
Japan
Prior art keywords
methyl
amino
lower alkyl
phenyl
pyridinyl
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Expired - Lifetime
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JP2004518718A
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English (en)
Japanese (ja)
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JP2005533827A5 (https=
JP2005533827A (ja
Inventor
ヴェルナー・ブライテンシュタイン
パスカル・フュレ
サンドラ・ジェイコブ
ポール・ウィリアム・マンリー
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ノバルティス アクチエンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2004518718A 2002-07-05 2003-07-04 チロシンキナーゼの阻害剤 Expired - Lifetime JP4110140B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0215676.8 2002-07-05
GBGB0215676.8A GB0215676D0 (en) 2002-07-05 2002-07-05 Organic compounds
GBGB0229893.3A GB0229893D0 (en) 2002-07-05 2002-12-20 Organic compounds
GB0229893.3 2002-12-20
PCT/EP2003/007198 WO2004005281A1 (en) 2002-07-05 2003-07-04 Inhibitors of tyrosine kinases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007283773A Division JP4895976B2 (ja) 2002-07-05 2007-10-31 チロシンキナーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2005533827A JP2005533827A (ja) 2005-11-10
JP2005533827A5 JP2005533827A5 (https=) 2008-04-24
JP4110140B2 true JP4110140B2 (ja) 2008-07-02

Family

ID=32178870

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2004518718A Expired - Lifetime JP4110140B2 (ja) 2002-07-05 2003-07-04 チロシンキナーゼの阻害剤
JP2007283773A Expired - Lifetime JP4895976B2 (ja) 2002-07-05 2007-10-31 チロシンキナーゼの阻害剤
JP2011153046A Pending JP2011219495A (ja) 2002-07-05 2011-07-11 チロシンキナーゼの阻害剤
JP2013168882A Pending JP2013227358A (ja) 2002-07-05 2013-08-15 チロシンキナーゼの阻害剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2007283773A Expired - Lifetime JP4895976B2 (ja) 2002-07-05 2007-10-31 チロシンキナーゼの阻害剤
JP2011153046A Pending JP2011219495A (ja) 2002-07-05 2011-07-11 チロシンキナーゼの阻害剤
JP2013168882A Pending JP2013227358A (ja) 2002-07-05 2013-08-15 チロシンキナーゼの阻害剤

Country Status (30)

Country Link
US (5) US7169791B2 (https=)
EP (4) EP2100891A1 (https=)
JP (4) JP4110140B2 (https=)
KR (2) KR100733639B1 (https=)
CN (2) CN1324022C (https=)
AR (1) AR040390A1 (https=)
AT (1) ATE414699T1 (https=)
AU (1) AU2003249962C9 (https=)
BR (1) BRPI0312464B8 (https=)
CA (3) CA2677313C (https=)
CO (1) CO5680432A2 (https=)
CY (1) CY1108813T1 (https=)
DE (1) DE60324805D1 (https=)
DK (1) DK1532138T3 (https=)
EC (1) ECSP055525A (https=)
ES (2) ES2475066T3 (https=)
GB (2) GB0215676D0 (https=)
IL (2) IL165977A (https=)
MX (1) MXPA05000328A (https=)
MY (1) MY143466A (https=)
NO (1) NO331166B1 (https=)
NZ (1) NZ537396A (https=)
PE (1) PE20040647A1 (https=)
PL (3) PL395096A1 (https=)
PT (2) PT2357182E (https=)
RU (2) RU2348627C2 (https=)
SI (1) SI1532138T1 (https=)
TW (1) TWI313603B (https=)
WO (1) WO2004005281A1 (https=)
ZA (1) ZA200410322B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008044968A (ja) * 2002-07-05 2008-02-28 Novartis Ag チロシンキナーゼの阻害剤

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