JP4105949B2 - プロテインキナーゼインヒビターとして有用なピラゾール化合物 - Google Patents
プロテインキナーゼインヒビターとして有用なピラゾール化合物 Download PDFInfo
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- JP4105949B2 JP4105949B2 JP2002526859A JP2002526859A JP4105949B2 JP 4105949 B2 JP4105949 B2 JP 4105949B2 JP 2002526859 A JP2002526859 A JP 2002526859A JP 2002526859 A JP2002526859 A JP 2002526859A JP 4105949 B2 JP4105949 B2 JP 4105949B2
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- 0 *c(cccc1)c1C(N)=N Chemical compound *c(cccc1)c1C(N)=N 0.000 description 110
- AEEMTZOWFJHGNW-UHFFFAOYSA-N Nc1nc(-c2ccccc2)nc2c1cccc2 Chemical compound Nc1nc(-c2ccccc2)nc2c1cccc2 AEEMTZOWFJHGNW-UHFFFAOYSA-N 0.000 description 5
- KZLXQMCMEDQJHY-UHFFFAOYSA-N Nc1nc(-c2ccccc2C(F)(F)F)nc2c1cccc2 Chemical compound Nc1nc(-c2ccccc2C(F)(F)F)nc2c1cccc2 KZLXQMCMEDQJHY-UHFFFAOYSA-N 0.000 description 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N C1CCNCC1 Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
- LPAGFVYQRIESJQ-UHFFFAOYSA-N C1c(cccc2)c2NC1 Chemical compound C1c(cccc2)c2NC1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 description 2
- KUSIXVQIZJSTBY-UHFFFAOYSA-N Nc1cc(-c2c(C(F)(F)F)cccc2)nc2c1cccc2 Chemical compound Nc1cc(-c2c(C(F)(F)F)cccc2)nc2c1cccc2 KUSIXVQIZJSTBY-UHFFFAOYSA-N 0.000 description 2
- YDTDKKULPWTHRV-UHFFFAOYSA-N Nc1n[nH]c2ccccc12 Chemical compound Nc1n[nH]c2ccccc12 YDTDKKULPWTHRV-UHFFFAOYSA-N 0.000 description 2
- RVXKCACCHHOFFA-UHFFFAOYSA-N Nc1nc(-c(cccc2)c2Cl)nc2c1cccc2 Chemical compound Nc1nc(-c(cccc2)c2Cl)nc2c1cccc2 RVXKCACCHHOFFA-UHFFFAOYSA-N 0.000 description 2
- LBUJPTNKIBCYBY-UHFFFAOYSA-N C(C1)CNc2c1cccc2 Chemical compound C(C1)CNc2c1cccc2 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 description 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N C1CCNCCC1 Chemical compound C1CCNCCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 description 1
- UWYZHKAOTLEWKK-UHFFFAOYSA-N C1c2ccccc2CNC1 Chemical compound C1c2ccccc2CNC1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 description 1
- IPSROODEFOIYSY-YMXPRXDMSA-N CC(/C=C(\N)/Nc1nc(-c2cc(I)ccc2)nc2c1cccc2)=N Chemical compound CC(/C=C(\N)/Nc1nc(-c2cc(I)ccc2)nc2c1cccc2)=N IPSROODEFOIYSY-YMXPRXDMSA-N 0.000 description 1
- QXWQJHTXIZRMTQ-UHFFFAOYSA-N CC(CC1)C(C2CC2)C=C1Nc1n[nH]c2c1cccc2 Chemical compound CC(CC1)C(C2CC2)C=C1Nc1n[nH]c2c1cccc2 QXWQJHTXIZRMTQ-UHFFFAOYSA-N 0.000 description 1
- CIZPNYVIGQXKPR-UHFFFAOYSA-N CC(NC(CC1)CCC1c1c(C)c(NC(c2ccccc2N)=N)nc(-c2c(C(F)(F)F)cccc2)n1)=O Chemical compound CC(NC(CC1)CCC1c1c(C)c(NC(c2ccccc2N)=N)nc(-c2c(C(F)(F)F)cccc2)n1)=O CIZPNYVIGQXKPR-UHFFFAOYSA-N 0.000 description 1
- UZOFELREXGAFOI-UHFFFAOYSA-N CC1CCNCC1 Chemical compound CC1CCNCC1 UZOFELREXGAFOI-UHFFFAOYSA-N 0.000 description 1
- QUPLTULZRMCAPW-UHFFFAOYSA-N CC1c(cccc2)c2C(Nc2nc(-c(cccc3)c3Cl)nc(N3CCNCC3)c2C)=C(C)CC1 Chemical compound CC1c(cccc2)c2C(Nc2nc(-c(cccc3)c3Cl)nc(N3CCNCC3)c2C)=C(C)CC1 QUPLTULZRMCAPW-UHFFFAOYSA-N 0.000 description 1
- VHXGLNHSTAQFNU-UHFFFAOYSA-O CCC(C(C(C)C)=C=C)=C([NH3+])[O]=CN Chemical compound CCC(C(C(C)C)=C=C)=C([NH3+])[O]=CN VHXGLNHSTAQFNU-UHFFFAOYSA-O 0.000 description 1
- WTLFPMDQXUVXRQ-UHFFFAOYSA-N CCC1C(C)=CC(Nc2nc(-c3ccccc3OCC)nc3c2cccc3)=C1 Chemical compound CCC1C(C)=CC(Nc2nc(-c3ccccc3OCC)nc3c2cccc3)=C1 WTLFPMDQXUVXRQ-UHFFFAOYSA-N 0.000 description 1
- RHWRYRPHWCBMOO-UHFFFAOYSA-N CCc1cc(NC2=NC(C)=C2)nc(-c2ccccc2)n1 Chemical compound CCc1cc(NC2=NC(C)=C2)nc(-c2ccccc2)n1 RHWRYRPHWCBMOO-UHFFFAOYSA-N 0.000 description 1
- SHSZUYYZDAAODG-UHFFFAOYSA-N COc(cccc1)c1-c1nc(cccc2)c2c(NC2=NCCCc3c2cccc3)n1 Chemical compound COc(cccc1)c1-c1nc(cccc2)c2c(NC2=NCCCc3c2cccc3)n1 SHSZUYYZDAAODG-UHFFFAOYSA-N 0.000 description 1
- CNCOHPOOIYWLLY-UHFFFAOYSA-N NC(C(CCC=C1)=C1N)NC1=NC(C2CCCCCC2)NC2C1CCCC2 Chemical compound NC(C(CCC=C1)=C1N)NC1=NC(C2CCCCCC2)NC2C1CCCC2 CNCOHPOOIYWLLY-UHFFFAOYSA-N 0.000 description 1
- KVOLWBAYFUDHNR-UHFFFAOYSA-N NC(c1ccccc1N)Nc1nc(C2CCCCCC2)nc2c1cccc2 Chemical compound NC(c1ccccc1N)Nc1nc(C2CCCCCC2)nc2c1cccc2 KVOLWBAYFUDHNR-UHFFFAOYSA-N 0.000 description 1
- CLZJXBXKXYZYOQ-UHFFFAOYSA-N NC1=NC(c2ccccc2)[N-]c2c1cccc2 Chemical compound NC1=NC(c2ccccc2)[N-]c2c1cccc2 CLZJXBXKXYZYOQ-UHFFFAOYSA-N 0.000 description 1
- IKBYMNJCZUJJKJ-UHFFFAOYSA-N Nc1cc(-c(cccc2)c2Cl)nc2c1cccc2 Chemical compound Nc1cc(-c(cccc2)c2Cl)nc2c1cccc2 IKBYMNJCZUJJKJ-UHFFFAOYSA-N 0.000 description 1
- NCVHVQHMSOJJBR-UHFFFAOYSA-N Nc1nc(-c(c(Cl)ccc2)c2Cl)nc2c1cccc2 Chemical compound Nc1nc(-c(c(Cl)ccc2)c2Cl)nc2c1cccc2 NCVHVQHMSOJJBR-UHFFFAOYSA-N 0.000 description 1
- MDGLKMXWHKGENE-UHFFFAOYSA-N Nc1nc(N2CCCCC2)nc2ccccc12 Chemical compound Nc1nc(N2CCCCC2)nc2ccccc12 MDGLKMXWHKGENE-UHFFFAOYSA-N 0.000 description 1
- KQKFQBTWXOGINC-UHFFFAOYSA-N OC1(CCNCC1)c1ccccc1 Chemical compound OC1(CCNCC1)c1ccccc1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 description 1
- XBXHCBLBYQEYTI-UHFFFAOYSA-N OCC1CCNCC1 Chemical compound OCC1CCNCC1 XBXHCBLBYQEYTI-UHFFFAOYSA-N 0.000 description 1
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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| US23279500P | 2000-09-15 | 2000-09-15 | |
| US25788700P | 2000-12-21 | 2000-12-21 | |
| US28694901P | 2001-04-27 | 2001-04-27 | |
| PCT/US2001/028803 WO2002022606A1 (en) | 2000-09-15 | 2001-09-14 | Pyrazole compounds useful as protein kinase inhibitors |
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| JP2004509116A5 JP2004509116A5 (enExample) | 2005-04-28 |
| JP4105949B2 true JP4105949B2 (ja) | 2008-06-25 |
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| JP2002526854A Expired - Fee Related JP4111824B2 (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| JP2002526860A Expired - Fee Related JP4170752B2 (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| JP2002526855A Expired - Fee Related JP4105947B2 (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なトリアゾール化合物 |
| JP2002526858A Pending JP2004509115A (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| JP2002526861A Pending JP2004509118A (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| JP2002526856A Expired - Fee Related JP4922539B2 (ja) | 2000-09-15 | 2001-09-14 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| JP2008015681A Pending JP2008115195A (ja) | 2000-09-15 | 2008-01-25 | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
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