|
US20090137416A1
(en)
|
2001-01-16 |
2009-05-28 |
Regeneron Pharmaceuticals, Inc. |
Isolating Cells Expressing Secreted Proteins
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
PT2314629E
(pt)
|
2002-07-18 |
2014-01-22 |
Merus B V |
Produção recombinante de misturas de anticorpos
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
EP2395016A3
(en)
|
2003-05-30 |
2012-12-19 |
Merus B.V. |
Design and use of paired variable regions of specific binding molecules
|
|
TWI671403B
(zh)
|
2005-03-31 |
2019-09-11 |
中外製藥股份有限公司 |
控制組裝之多肽的製造方法
|
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
EP3479844B1
(en)
|
2005-04-15 |
2023-11-22 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9963510B2
(en)
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US11254748B2
(en)
|
2005-04-15 |
2022-02-22 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
IN2014DN10515A
(enExample)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
|
WO2007114325A1
(ja)
|
2006-03-31 |
2007-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
二重特異性抗体を精製するための抗体改変方法
|
|
MX336725B
(es)
|
2007-09-26 |
2016-01-28 |
Chugai Pharmaceutical Co Ltd |
Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
|
|
DK3059246T3
(en)
|
2007-09-26 |
2018-10-01 |
Chugai Pharmaceutical Co Ltd |
Modified constant region of an antibody
|
|
TWI700293B
(zh)
|
2008-04-11 |
2020-08-01 |
日商中外製藥股份有限公司 |
重複結合複數個抗原的抗體
|
|
JP5787446B2
(ja)
|
2009-03-19 |
2015-09-30 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2409991B1
(en)
|
2009-03-19 |
2017-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
KR101747103B1
(ko)
|
2009-06-26 |
2017-06-14 |
리제너론 파마슈티칼스 인코포레이티드 |
천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
|
|
KR101764449B1
(ko)
*
|
2009-09-01 |
2017-08-02 |
제넨테크, 인크. |
변형된 단백질 a 용리를 통한 증진된 단백질 정제
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
RU2606264C2
(ru)
*
|
2009-12-25 |
2017-01-10 |
Чугаи Сеияку Кабушики Каиша |
Способ полипептидной модификации для очистки полипептидных мультимеров
|
|
US20130045492A1
(en)
*
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US10143186B2
(en)
|
2010-02-08 |
2018-12-04 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
PL2560993T3
(pl)
*
|
2010-04-20 |
2024-11-04 |
Genmab A/S |
Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania
|
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
|
EP3029066B1
(en)
|
2010-07-29 |
2019-02-20 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
EP3960865A1
(en)
*
|
2010-08-02 |
2022-03-02 |
Regeneron Pharmaceuticals, Inc. |
Mice that make binding proteins comprising vl domains
|
|
CA2807127C
(en)
|
2010-08-02 |
2019-02-12 |
Leslie S. Johnson |
Covalent diabodies and uses thereof
|
|
AU2011325833C1
(en)
|
2010-11-05 |
2017-07-13 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
JP6013915B2
(ja)
|
2010-11-17 |
2016-10-25 |
中外製薬株式会社 |
血液凝固第viii因子の機能を代替する機能を有する多重特異性抗原結合分子
|
|
JO3756B1
(ar)
|
2010-11-23 |
2021-01-31 |
Regeneron Pharma |
اجسام مضادة بشرية لمستقبلات الجلوكاجون
|
|
PT3434767T
(pt)
|
2010-11-30 |
2026-01-23 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico indutor de citotoxicidade
|
|
KR102568454B1
(ko)
|
2010-11-30 |
2023-08-18 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
|
|
WO2012132067A1
(ja)
*
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
|
EP3604330A1
(en)
*
|
2011-02-25 |
2020-02-05 |
Chugai Seiyaku Kabushiki Kaisha |
Fcgammariib-specific fc antibody
|
|
TWI588156B
(zh)
|
2011-03-28 |
2017-06-21 |
賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
KR102639563B1
(ko)
*
|
2011-03-30 |
2024-02-21 |
추가이 세이야쿠 가부시키가이샤 |
항원 결합 분자의 혈장 체류성과 면역원성을 개변하는 방법
|
|
WO2012162068A2
(en)
|
2011-05-21 |
2012-11-29 |
Macrogenics, Inc. |
Deimmunized serum-binding domains and their use for extending serum half-life
|
|
US9890218B2
(en)
*
|
2011-06-30 |
2018-02-13 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
HRP20192255T1
(hr)
|
2011-08-05 |
2020-03-06 |
Regeneron Pharmaceuticals, Inc. |
Humanizirani miševi s univerzalnim lakim lancem
|
|
CA2791109C
(en)
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
HRP20220253T1
(hr)
*
|
2011-10-17 |
2022-04-29 |
Regeneron Pharmaceuticals, Inc. |
Miševi s ograničenim teškim lancem imunoglobulina
|
|
HUE044633T2
(hu)
|
2011-10-27 |
2019-11-28 |
Genmab As |
Heterodimer fehérjék elõállítása
|
|
EP2787078B1
(en)
|
2011-10-31 |
2019-05-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
|
AU2012332021B8
(en)
|
2011-11-04 |
2017-10-12 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
WO2014067011A1
(en)
|
2012-11-02 |
2014-05-08 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
|
RS56796B1
(sr)
|
2011-11-14 |
2018-04-30 |
Regeneron Pharma |
Kompozicije i postupci za uvećanje mišićne mase i jačine mišića specifičnim antagonizovanjem gdf8 i/ili aktivina a
|
|
EP2790681B9
(en)
|
2011-11-18 |
2023-07-26 |
Regeneron Pharmaceuticals, Inc. |
Method of manufacturing an extended release pharmaceutical formulation comprising polymer coated protein microparticles using spray-drying
|
|
BR112014013081A2
(pt)
|
2011-11-30 |
2020-10-20 |
Chugai Seiyaku Kabushiki Kaisha |
veículo contendo fármaco em célula para formação de um complexo imune
|
|
HRP20201004T1
(hr)
*
|
2011-12-20 |
2020-10-16 |
Medimmune, Llc |
Modificirani polipeptidi za skelete bispecifičnog protutijela
|
|
JP6226752B2
(ja)
|
2012-02-09 |
2017-11-08 |
中外製薬株式会社 |
抗体のFc領域改変体
|
|
SG10201610123UA
(en)
|
2012-03-02 |
2017-01-27 |
Regeneron Pharma |
Human antibodies to clostridium difficile toxins
|
|
CA2865029A1
(en)
|
2012-03-06 |
2013-09-12 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
EP2825559B1
(en)
|
2012-03-13 |
2019-02-27 |
Novimmune SA |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
|
PT2825037T
(pt)
|
2012-03-16 |
2019-08-07 |
Regeneron Pharma |
Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph
|
|
SMT201800395T1
(it)
|
2012-03-16 |
2018-09-13 |
Regeneron Pharma |
Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi
|
|
RU2014141536A
(ru)
|
2012-03-16 |
2016-05-10 |
Регенерон Фармасьютикалз, Инк. |
Мыши, которые продуцируют антигенсвязывающие белки с зависимыми от величины ph характеристиками связывания
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
DK2838917T3
(da)
|
2012-04-20 |
2019-08-26 |
Merus Nv |
Fremgangsmåder og midler til frembringelse af heterodimere ig-lignende molekyler
|
|
MX382840B
(es)
|
2012-04-27 |
2025-03-13 |
Bioatla Llc |
Regiones de anticuerpo modificado y sus usos.
|
|
KR102484480B1
(ko)
|
2012-06-12 |
2023-01-04 |
리제너론 파마슈티칼스 인코포레이티드 |
제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
|
|
JP6628966B2
(ja)
|
2012-06-14 |
2020-01-15 |
中外製薬株式会社 |
改変されたFc領域を含む抗原結合分子
|
|
US9499634B2
(en)
|
2012-06-25 |
2016-11-22 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
EP3632462A1
(en)
|
2012-07-06 |
2020-04-08 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
AU2013285355A1
(en)
|
2012-07-06 |
2015-01-29 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
US20150203591A1
(en)
|
2012-08-02 |
2015-07-23 |
Regeneron Pharmaceuticals, Inc. |
Mutivalent antigen-binding proteins
|
|
JO3462B1
(ar)
|
2012-08-22 |
2020-07-05 |
Regeneron Pharma |
أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها
|
|
TWI855488B
(zh)
|
2012-08-24 |
2024-09-11 |
日商中外製藥股份有限公司 |
FcγRIIb特異性Fc區域變異體
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
EP2900696A1
(en)
*
|
2012-09-25 |
2015-08-05 |
Glenmark Pharmaceuticals S.A. |
Purification of hetero-dimeric immunoglobulins
|
|
HRP20181717T1
(hr)
*
|
2012-09-27 |
2018-12-28 |
Merus N.V. |
Bispecifična igg protutijela kao aktivatori t stanice
|
|
EP2905290B1
(en)
*
|
2012-10-05 |
2019-12-04 |
Kyowa Kirin Co., Ltd. |
Heterodimeric protein composition
|
|
WO2014069647A1
(ja)
|
2012-11-05 |
2014-05-08 |
全薬工業株式会社 |
抗体又は抗体組成物の製造方法
|
|
TWI675044B
(zh)
|
2012-11-14 |
2019-10-21 |
美商再生元醫藥公司 |
重組細胞表面捕捉蛋白質
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
US10077298B2
(en)
|
2012-11-28 |
2018-09-18 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
ES2876009T3
(es)
|
2012-12-27 |
2021-11-11 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado
|
|
KR20240123420A
(ko)
|
2013-01-10 |
2024-08-13 |
젠맵 비. 브이 |
인간 IgG1 Fc 영역 변이체 및 그의 용도
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CN105051069B
(zh)
|
2013-01-14 |
2019-12-10 |
Xencor股份有限公司 |
新型异二聚体蛋白
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
TWI635098B
(zh)
*
|
2013-02-01 |
2018-09-11 |
再生元醫藥公司 |
含嵌合恆定區之抗體
|
|
LT2840892T
(lt)
|
2013-02-20 |
2018-07-25 |
Regeneron Pharmaceuticals, Inc. |
Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis
|
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
|
LT3501272T
(lt)
|
2013-03-13 |
2023-03-27 |
Regeneron Pharmaceuticals, Inc. |
Pelės, vykdančios imunoglobulino lengvosios grandinės riboto rinkinio raišką
|
|
SG11201506294TA
(en)
|
2013-03-13 |
2015-09-29 |
Regeneron Pharma |
Common light chain mouse
|
|
EP2968520B1
(en)
|
2013-03-14 |
2021-05-12 |
MacroGenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor
|
|
DK2970379T3
(da)
*
|
2013-03-14 |
2019-07-22 |
Emd Millipore Corp |
Fremgangsmåder til forhøjelse af proteinrenhed ved anvendelse af protein a-baseret kromatografi
|
|
CN105189548A
(zh)
|
2013-03-14 |
2015-12-23 |
瑞泽恩制药公司 |
Grem1的人抗体
|
|
EP3421495A3
(en)
|
2013-03-15 |
2019-05-15 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
AR095196A1
(es)
|
2013-03-15 |
2015-09-30 |
Regeneron Pharma |
Medio de cultivo celular libre de suero
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
KR102049990B1
(ko)
|
2013-03-28 |
2019-12-03 |
삼성전자주식회사 |
c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
|
|
AU2014250434B2
(en)
|
2013-04-02 |
2019-08-08 |
Chugai Seiyaku Kabushiki Kaisha |
Fc region variant
|
|
US11357866B2
(en)
*
|
2013-04-03 |
2022-06-14 |
The Administrators Of The Tulane Educational Fund |
Expression of HIV inhibitors by mesenchymal stem cells
|
|
EP3628685A1
(en)
|
2013-04-29 |
2020-04-01 |
F. Hoffmann-La Roche AG |
Human fcrn-binding modified antibodies and methods of use
|
|
US20160068613A1
(en)
*
|
2013-04-29 |
2016-03-10 |
Hoffmann-La Roche Inc. |
Fc-receptor binding modified asymmetric antibodies and methods of use
|
|
TW201920262A
(zh)
|
2013-07-30 |
2019-06-01 |
美商再生元醫藥公司 |
抗活化素a之抗體及其用途
|
|
UA116479C2
(uk)
|
2013-08-09 |
2018-03-26 |
Макродженікс, Інк. |
БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
|
|
US11384149B2
(en)
|
2013-08-09 |
2022-07-12 |
Macrogenics, Inc. |
Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
|
|
EP2840091A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
|
|
EP2839842A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
|
|
CA2922979A1
(en)
*
|
2013-09-03 |
2015-03-12 |
Novimmune S.A. |
Readily isolated bispecific binding molecules with native format having mutated constant regions
|
|
US9481729B2
(en)
*
|
2013-09-11 |
2016-11-01 |
The University Of Hong Kong |
Anti-HER2 and anti-IGF-IR BI-specific antibodies and uses thereof
|
|
KR20200103882A
(ko)
|
2013-09-18 |
2020-09-02 |
리제너론 파마슈티칼스 인코포레이티드 |
히스티딘 엔지니어링된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-인간 동물
|
|
SG10201803449VA
(en)
*
|
2013-09-27 |
2018-05-30 |
Chugai Pharmaceutical Co Ltd |
Method for producing polypeptide heteromultimer
|
|
EP3066133A1
(en)
*
|
2013-11-04 |
2016-09-14 |
Glenmark Pharmaceuticals S.A. |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
EA201691027A1
(ru)
|
2013-11-20 |
2016-12-30 |
Ридженерон Фармасьютикалз, Инк. |
Модуляторы aplnr и их применение
|
|
PT3074424T
(pt)
|
2013-11-27 |
2025-05-29 |
Zymeworks Bc Inc |
Construções de ligação a antigénio biespecíficas direcionadas a her2
|
|
KR102225489B1
(ko)
|
2013-12-17 |
2021-03-10 |
제넨테크, 인크. |
항-cd3 항체 및 이의 사용 방법
|
|
JP2017029001A
(ja)
*
|
2013-12-19 |
2017-02-09 |
国立研究開発法人産業技術総合研究所 |
プロテインgの細胞膜外ドメインの新規な改変型タンパク質
|
|
CA2932364A1
(en)
|
2014-01-15 |
2015-07-23 |
F. Hoffmann-La Roche Ag |
Fc-region variants with improved protein a-binding
|
|
WO2015107026A1
(en)
|
2014-01-15 |
2015-07-23 |
F. Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn- and maintained protein a-binding properties
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
|
HK1231374A1
(zh)
*
|
2014-02-21 |
2017-12-22 |
Regeneron Pharmaceuticals, Inc. |
用於靶抗原的细胞特异性调变的方法、组合物和试剂盒
|
|
ES2816624T3
(es)
|
2014-02-28 |
2021-04-05 |
Merus Nv |
Anticuerpos que se unen a EGFR y ERBB3
|
|
HRP20250041T1
(hr)
|
2014-02-28 |
2025-03-14 |
Merus N.V. |
Antitijelo koje veže erbb-2 i erbb-3
|
|
TWI701042B
(zh)
*
|
2014-03-19 |
2020-08-11 |
美商再生元醫藥公司 |
用於腫瘤治療之方法及抗體組成物
|
|
BR112016021679A2
(pt)
|
2014-03-21 |
2018-12-04 |
Regeneron Pharmaceuticals, Inc. |
proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado.
|
|
SG10201808225TA
(en)
|
2014-03-21 |
2018-10-30 |
Regeneron Pharma |
Non-human animals that make single domain binding proteins
|
|
KR102497443B1
(ko)
|
2014-03-28 |
2023-02-08 |
젠코어 인코포레이티드 |
Cd38 및 cd3에 결합하는 이중특이적 항체
|
|
ES2900898T3
(es)
|
2014-04-07 |
2022-03-18 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos biespecíficos inmunoactivadores
|
|
CA2947157A1
(en)
|
2014-05-13 |
2015-11-19 |
Chugai Seiyaku Kabushiki Kaisha |
T cell-redirected antigen-binding molecule for cells having immunosuppression function
|
|
JO3701B1
(ar)
|
2014-05-23 |
2021-01-31 |
Regeneron Pharma |
مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
|
|
AU2015266958A1
(en)
|
2014-05-28 |
2016-12-08 |
Agenus Inc. |
Anti-GITR antibodies and methods of use thereof
|
|
DK3107938T3
(da)
|
2014-05-28 |
2022-07-11 |
Zymeworks Inc |
Modificerede, antigenbindende polypeptidkonstrukter og anvendelser heraf
|
|
TWI742423B
(zh)
|
2014-05-29 |
2021-10-11 |
美商宏觀基因股份有限公司 |
特異性結合多種癌症抗原的三特異性結合分子和其使用方法
|
|
AR101262A1
(es)
*
|
2014-07-26 |
2016-12-07 |
Regeneron Pharma |
Plataforma de purificación para anticuerpos biespecíficos
|
|
WO2016019969A1
(en)
|
2014-08-08 |
2016-02-11 |
Ludwig-Maximilians-Universität München |
Subcutaneously administered bispecific antibodies for use in the treatment of cancer
|
|
SG11201701627PA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Anti-cll-1 antibodies and immunoconjugates
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
US10717778B2
(en)
|
2014-09-29 |
2020-07-21 |
Duke University |
Bispecific molecules comprising an HIV-1 envelope targeting arm
|
|
US11773166B2
(en)
|
2014-11-04 |
2023-10-03 |
Ichnos Sciences SA |
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
|
|
MA40894A
(fr)
*
|
2014-11-04 |
2017-09-12 |
Glenmark Pharmaceuticals Sa |
Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production
|
|
SI3215528T1
(sl)
*
|
2014-11-06 |
2019-11-29 |
Hoffmann La Roche |
Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe
|
|
EP3215524B1
(en)
|
2014-11-06 |
2021-01-13 |
F.Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn- and protein a-binding properties
|
|
AU2015350075B2
(en)
|
2014-11-17 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Methods for tumor treatment using CD3xCD20 bispecific antibody
|
|
US11566082B2
(en)
|
2014-11-17 |
2023-01-31 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
BR112017011166A2
(pt)
|
2014-11-26 |
2018-02-27 |
Xencor, Inc. |
anticorpos heterodiméricos que se ligam a cd3 e cd38
|
|
CA2967426A1
(en)
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and tumor antigens
|
|
DK3029137T3
(en)
|
2014-12-06 |
2019-04-08 |
Gemoab Monoclonals Gmbh |
GENETICALLY MODIFIED PLURI OR MULTIPOTENT STEM CELLS AND USE THEREOF
|
|
TWI702229B
(zh)
|
2014-12-19 |
2020-08-21 |
美商再生元醫藥公司 |
流行性感冒病毒血球凝集素之人類抗體
|
|
US10221248B2
(en)
|
2014-12-22 |
2019-03-05 |
The Rockefeller University |
Anti-MERTK agonistic antibodies and uses thereof
|
|
EP3237449A2
(en)
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
|
WO2016141387A1
(en)
|
2015-03-05 |
2016-09-09 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
EP4190817A1
(en)
|
2015-03-17 |
2023-06-07 |
Memorial Sloan Kettering Cancer Center |
Anti-muc16 antibodies and uses thereof
|
|
HK1250038A1
(zh)
|
2015-03-19 |
2018-11-23 |
瑞泽恩制药公司 |
选择结合抗原的轻链可变区的非人动物
|
|
TWI804917B
(zh)
|
2015-03-27 |
2023-06-11 |
美商再生元醫藥公司 |
偵測生物污染物之組成物及方法
|
|
US10556952B2
(en)
|
2015-03-30 |
2020-02-11 |
Regeneron Pharmaceuticals, Inc. |
Heavy chain constant regions with reduced binding to Fc gamma receptors
|
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
JP6877357B2
(ja)
|
2015-04-15 |
2021-05-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
Gdf8阻害剤を用いて、強度及び機能を増加させる方法
|
|
JP7240812B2
(ja)
|
2015-05-12 |
2023-03-16 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
多量体タンパク質の純度の決定
|
|
SI3303394T1
(sl)
|
2015-05-29 |
2020-10-30 |
Agenus Inc. |
Protitelesa proti-CTLA-4 in postopki njihove uporabe
|
|
MX395604B
(es)
|
2015-06-15 |
2025-03-25 |
Numab Therapeutics AG |
Formato de anticuerpo multiespecífico heterodimérico.
|
|
TW201718647A
(zh)
|
2015-06-16 |
2017-06-01 |
建南德克公司 |
抗-cll-1抗體及使用方法
|
|
WO2016207278A1
(en)
|
2015-06-23 |
2016-12-29 |
Innate Pharma |
Multispecific nk engager proteins
|
|
US11191844B2
(en)
|
2015-07-06 |
2021-12-07 |
Regeneran Pharmaceuticals, Inc. |
Multispecific antigen-binding molecules and uses thereof
|
|
US20180201693A1
(en)
|
2015-07-09 |
2018-07-19 |
Genmab A/S |
Bispecific and multispecific antibodies and method for isolation of such
|
|
CA2991805A1
(en)
|
2015-07-10 |
2017-01-19 |
Genmab A/S |
Axl-specific antibody-drug conjugates for cancer treatment
|
|
ES2693596T3
(es)
|
2015-07-10 |
2018-12-12 |
Merus N.V. |
Anticuerpo que se une a CD3 humano
|
|
JOP20160154B1
(ar)
|
2015-07-31 |
2021-08-17 |
Regeneron Pharma |
أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
|
|
TWI899515B
(zh)
|
2015-08-04 |
2025-10-01 |
美商再生元醫藥公司 |
補充牛磺酸之細胞培養基及用法
|
|
KR102095096B1
(ko)
*
|
2015-08-26 |
2020-03-30 |
바이슨 테라퓨틱스 인크. |
다중특이적 항체 플랫폼 및 관련 방법
|
|
CN114605548A
(zh)
|
2015-09-01 |
2022-06-10 |
艾吉纳斯公司 |
抗-pd-1抗体及其使用方法
|
|
TWI784917B
(zh)
|
2015-09-23 |
2022-11-21 |
美商再生元醫藥公司 |
最優化抗cd3雙特異性抗體及其用途
|
|
PT3359576T
(pt)
|
2015-10-08 |
2025-03-27 |
Zymeworks Bc Inc |
Constructos de polipeptídeo de ligação a antigénio compreendendo cadeias leves capa e lambda e usos dos mesmos
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗lag3抗體及其用途
|
|
KR20250157457A
(ko)
|
2015-10-23 |
2025-11-04 |
메뤼스 엔.페. |
암 성장을 억제하는 결합 분자
|
|
CN108602884B
(zh)
|
2015-11-08 |
2024-06-25 |
豪夫迈·罗氏有限公司 |
筛选多特异性抗体的方法
|
|
WO2017086367A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法
|
|
JP6925278B2
(ja)
|
2015-11-18 |
2021-08-25 |
中外製薬株式会社 |
液性免疫応答の増強方法
|
|
WO2017093448A1
(en)
|
2015-12-01 |
2017-06-08 |
Genmab B.V. |
Anti-dr5 antibodies and methods of use thereof
|
|
CN108699136B
(zh)
|
2015-12-07 |
2022-03-18 |
Xencor股份有限公司 |
结合cd3和psma的异二聚抗体
|
|
MA44146B1
(fr)
|
2015-12-22 |
2023-10-31 |
Regeneron Pharma |
Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer
|
|
CA3004288C
(en)
*
|
2015-12-28 |
2025-05-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION
|
|
GB201602156D0
(en)
*
|
2016-02-05 |
2016-03-23 |
Jones Philip C And Boku University Of Natural Resources And Life Sciences |
Heterodimers and purification thereof
|
|
TW202214700A
(zh)
|
2016-03-14 |
2022-04-16 |
日商中外製藥股份有限公司 |
用於癌之治療的細胞傷害誘導治療劑
|
|
CA3016563A1
(en)
|
2016-03-21 |
2017-09-28 |
Elstar Therapeutics, Inc. |
Multispecific and multifunctional molecules and uses thereof
|
|
KR102906454B1
(ko)
*
|
2016-04-20 |
2026-01-02 |
리제너론 파마슈티칼스 인코포레이티드 |
발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법
|
|
SG11201807881VA
(en)
*
|
2016-04-20 |
2018-10-30 |
Regeneron Pharma |
Compositions and methods for making antibodies based on use of an expression-enhancing locus
|
|
EP3448891A1
(en)
|
2016-04-28 |
2019-03-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of making multispecific antigen-binding molecules
|
|
AU2017255077B2
(en)
|
2016-04-28 |
2024-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody-containing preparation
|
|
JP7031934B2
(ja)
|
2016-05-11 |
2022-03-08 |
サイティバ・バイオプロセス・アールアンドディ・アクチボラグ |
分離マトリックス
|
|
US10654887B2
(en)
|
2016-05-11 |
2020-05-19 |
Ge Healthcare Bio-Process R&D Ab |
Separation matrix
|
|
US10703774B2
(en)
|
2016-09-30 |
2020-07-07 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
WO2017194593A1
(en)
|
2016-05-11 |
2017-11-16 |
Ge Healthcare Bioprocess R&D Ab |
Method of cleaning and/or sanitizing a separation matrix
|
|
US10889615B2
(en)
|
2016-05-11 |
2021-01-12 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
US10513537B2
(en)
|
2016-05-11 |
2019-12-24 |
Ge Healthcare Bioprocess R&D Ab |
Separation matrix
|
|
US10730908B2
(en)
|
2016-05-11 |
2020-08-04 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
CN109311949B
(zh)
|
2016-05-11 |
2022-09-16 |
思拓凡生物工艺研发有限公司 |
储存分离基质的方法
|
|
TWI786044B
(zh)
|
2016-05-13 |
2022-12-11 |
美商再生元醫藥公司 |
藉由投予pd-1抑制劑治療皮膚癌之方法
|
|
CN109475109B
(zh)
|
2016-05-20 |
2021-10-29 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
TWI781934B
(zh)
|
2016-05-27 |
2022-11-01 |
美商艾吉納斯公司 |
抗-tim-3抗體及其使用方法
|
|
CA3026151A1
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
|
KR102667023B1
(ko)
|
2016-06-14 |
2024-05-21 |
리제너론 파아마슈티컬스, 인크. |
항-c5 항체 및 이의 용도
|
|
MX2018016265A
(es)
|
2016-06-28 |
2019-07-04 |
Xencor Inc |
Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina.
|
|
JP7308034B2
(ja)
|
2016-07-01 |
2023-07-13 |
リゾルブ セラピューティクス, エルエルシー |
最適化二重ヌクレアーゼ融合物および方法
|
|
KR20190039937A
(ko)
|
2016-07-08 |
2019-04-16 |
스태튼 바이오테크놀로지 비.브이. |
항-ApoC3 항체 및 이의 사용 방법
|
|
TW201815821A
(zh)
|
2016-07-18 |
2018-05-01 |
美商再生元醫藥公司 |
抗茲卡病毒抗體及使用方法
|
|
MA45999A
(fr)
|
2016-08-22 |
2019-06-26 |
Arbutus Biopharma Corp |
Anticorps anti-pd-1, ou leurs fragments, pour le traitement de l'hépatite b
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
HRP20221202T1
(hr)
|
2016-09-23 |
2022-12-09 |
Regeneron Pharmaceuticals, Inc. |
Anti-muc16 (mucin 16) antitijela
|
|
WO2018058001A1
(en)
|
2016-09-23 |
2018-03-29 |
Regeneron Pharmaceuticals, Inc. |
Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
|
|
US12448411B2
(en)
|
2016-09-30 |
2025-10-21 |
Cytiva Bioprocess R&D Ab |
Separation method
|
|
TW202436356A
(zh)
|
2016-10-11 |
2024-09-16 |
美商艾吉納斯公司 |
抗lag-3抗體及其使用方法
|
|
PE20240950A1
(es)
|
2016-10-14 |
2024-05-06 |
Xencor Inc |
PROTEINAS DE FUSION FC HETERODIMERICAS IL 15/IL 15R(alfa)
|
|
WO2018083126A1
(en)
|
2016-11-01 |
2018-05-11 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
KR102539159B1
(ko)
|
2016-11-07 |
2023-06-02 |
주식회사 뉴라클사이언스 |
서열 유사성을 가진 항-패밀리 19, 멤버 a5 항체 및 그것의 사용 방법
|
|
US11466094B2
(en)
|
2016-11-15 |
2022-10-11 |
Genentech, Inc. |
Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
|
|
US11013802B2
(en)
|
2016-12-07 |
2021-05-25 |
Agenus Inc. |
Anti-CTLA-4 antibodies and methods of use thereof
|
|
BR112019012354A2
(pt)
|
2016-12-21 |
2019-11-26 |
Teneobio, Inc. |
anticorpos apenas de cadeia pesada anti-bcma
|
|
WO2018115262A1
(en)
|
2016-12-23 |
2018-06-28 |
Innate Pharma |
Heterodimeric antigen binding proteins
|
|
TWI781130B
(zh)
|
2017-01-03 |
2022-10-21 |
美商再生元醫藥公司 |
抗金黃色葡萄球菌溶血素a毒素之人類抗體
|
|
WO2018147245A1
(ja)
|
2017-02-07 |
2018-08-16 |
第一三共株式会社 |
抗gprc5d抗体及び該抗体を含む分子
|
|
KR20190115057A
(ko)
|
2017-02-10 |
2019-10-10 |
젠맵 비. 브이 |
폴리펩티드 변이체 및 그의 용도
|
|
AU2018219909B2
(en)
|
2017-02-10 |
2025-02-27 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled anti-LAG3 antibodies for immuno-PET imaging
|
|
US20200291089A1
(en)
|
2017-02-16 |
2020-09-17 |
Elstar Therapeutics, Inc. |
Multifunctional molecules comprising a trimeric ligand and uses thereof
|
|
US10626169B2
(en)
|
2017-02-17 |
2020-04-21 |
Sanofi |
Multispecific binding molecules having specificity to dystroglycan and laminin-2
|
|
CA3053774A1
(en)
|
2017-02-17 |
2018-08-23 |
Sanofi |
Multispecific binding molecules having specificity to dystroglycan and laminin-2
|
|
EP4659808A3
(en)
|
2017-02-17 |
2026-03-11 |
Sanofi |
Multispecific binding molecules having specificity to dystroglycan and laminin-2
|
|
EP3589650A1
(en)
|
2017-03-02 |
2020-01-08 |
Novartis AG |
Engineered heterodimeric proteins
|
|
MX2019011624A
(es)
|
2017-03-27 |
2019-12-05 |
Celgene Corp |
Metodos y composiciones para la reduccion de la inmunogenicidad.
|
|
WO2018182422A1
(en)
|
2017-03-31 |
2018-10-04 |
Merus N.V. |
Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
|
|
WO2018178396A1
(en)
|
2017-03-31 |
2018-10-04 |
Genmab Holding B.V. |
Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
|
|
US11603407B2
(en)
|
2017-04-06 |
2023-03-14 |
Regeneron Pharmaceuticals, Inc. |
Stable antibody formulation
|
|
SG11201909160WA
(en)
|
2017-04-11 |
2019-10-30 |
Inhibrx Inc |
Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
|
|
KR102629972B1
(ko)
|
2017-04-13 |
2024-01-29 |
아게누스 인코포레이티드 |
항-cd137 항체 및 이의 사용 방법
|
|
CA3059133A1
(en)
|
2017-04-21 |
2018-10-25 |
Staten Biotechnology B.V. |
Anti-apoc3 antibodies and methods of use thereof
|
|
US11021537B2
(en)
|
2017-05-01 |
2021-06-01 |
Agenus Inc. |
Anti-TIGIT antibodies and methods of use thereof
|
|
CN111148764B
(zh)
|
2017-05-17 |
2025-08-12 |
美勒斯公司 |
用于乳腺癌的ErbB-2/ErbB-3双特异性抗体与内分泌治疗的组合
|
|
WO2018222901A1
(en)
|
2017-05-31 |
2018-12-06 |
Elstar Therapeutics, Inc. |
Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
|
|
CN110785185B
(zh)
*
|
2017-06-05 |
2024-05-24 |
詹森生物科技公司 |
具有非对称ch2-ch3区突变的工程化多特异性抗体和其他多聚体蛋白
|
|
US12098203B2
(en)
|
2017-06-05 |
2024-09-24 |
Numab Therapeutics AG |
Hetero-dimeric multi-specific antibody format targeting at least CD3 and HSA
|
|
EP3635009B1
(en)
|
2017-06-07 |
2026-02-25 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for internalizing enzymes
|
|
MX2019014407A
(es)
|
2017-06-07 |
2020-02-05 |
Genmab Bv |
Anticuerpos terapeuticos basados en hexameros de inmunoglobulina g (igg) mutados.
|
|
EP3641768B1
(en)
|
2017-06-21 |
2025-12-31 |
iCell Gene Therapeutics LLC |
Chimeric Antigen Receptors (CARs), Compositions and Associated Methods
|
|
GB201709970D0
(en)
|
2017-06-22 |
2017-08-09 |
Kymab Ltd |
Bispecific antigen-binding molecules
|
|
JP7278978B2
(ja)
|
2017-06-27 |
2023-05-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化asgr1座位を含む非ヒト動物
|
|
KR102905526B1
(ko)
|
2017-06-27 |
2025-12-30 |
주식회사 뉴라클사이언스 |
항-fam19a5 항체 및 이의 용도
|
|
CN110799524A
(zh)
|
2017-06-27 |
2020-02-14 |
瑞泽恩制药公司 |
向性修饰的重组病毒载体及其用于将遗传材料靶向引入人细胞内的用途
|
|
EP3645041A4
(en)
|
2017-06-28 |
2021-03-17 |
The Rockefeller University |
AGONISTIC ANTIBODY-ANTIBODY-ACTIVE INGREDIENT CONJUGATES AGAINST MERTK AND THEIR USES
|
|
MA49512A
(fr)
|
2017-06-28 |
2020-05-06 |
Regeneron Pharma |
Protéines de liaison à l'antigène anti-papillomavirus humain et leurs méthodés d'utilisation
|
|
AU2018291497A1
(en)
|
2017-06-30 |
2020-01-16 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
|
|
JP6982226B2
(ja)
*
|
2017-07-06 |
2021-12-17 |
日東紡績株式会社 |
抗ヒトIgG4モノクローナル抗体、およびその抗体を利用したヒトIgG4測定試薬
|
|
CN114075269A
(zh)
|
2017-07-06 |
2022-02-22 |
菲仕兰坎皮纳荷兰私人有限公司 |
用于制备糖蛋白的细胞培养工艺
|
|
TWI865430B
(zh)
|
2017-07-24 |
2024-12-11 |
美商再生元醫藥公司 |
穩定化之抗體組合物及其製法
|
|
TWI799432B
(zh)
|
2017-07-27 |
2023-04-21 |
美商再生元醫藥公司 |
抗ctla-4抗體及其用途
|
|
EP3661555B1
(en)
*
|
2017-08-01 |
2025-04-16 |
Ab Therapeutics, Inc. |
Bispecific antibodies and uses thereof
|
|
ES2910969T3
(es)
|
2017-08-03 |
2022-05-17 |
Amgen Inc |
Muteínas de interleucina-21 y métodos de tratamiento
|
|
WO2019025545A1
(en)
|
2017-08-04 |
2019-02-07 |
Genmab A/S |
BINDING AGENTS BINDING TO PD-L1 AND CD137 AND THEIR USE
|
|
PL3665198T3
(pl)
|
2017-08-09 |
2025-06-09 |
Merus N.V. |
Przeciwciała wiążące egfr i cmet
|
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
|
WO2019040674A1
(en)
|
2017-08-22 |
2019-02-28 |
Sanabio, Llc |
SOLUBLE INTERFERON RECEPTORS AND USES THEREOF
|
|
ES2928576T3
(es)
|
2017-09-08 |
2022-11-21 |
Amgen Inc |
Inhibidores de KRAS G12C y métodos de uso de los mismos
|
|
JP7403441B2
(ja)
*
|
2017-09-14 |
2023-12-22 |
デナリ セラピューティクス インコーポレイテッド |
抗trem2抗体及びその使用方法
|
|
ES2962277T3
(es)
|
2017-09-29 |
2024-03-18 |
Regeneron Pharma |
Roedores que comprenden un locus Ttr humanizado y métodos de uso
|
|
SG11202001160XA
(en)
|
2017-09-29 |
2020-03-30 |
Regeneron Pharma |
Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof
|
|
CA3076630A1
(en)
|
2017-10-04 |
2019-04-11 |
Amgen Inc. |
Transthyretin immunoglobulin fusions
|
|
WO2019077092A1
(en)
|
2017-10-20 |
2019-04-25 |
F. Hoffmann-La Roche Ag |
METHOD FOR GENERATING MULTISPECIFIC ANTIBODIES FROM MONOSPECIFIC ANTIBODIES
|
|
KR102831164B1
(ko)
|
2017-10-30 |
2025-07-07 |
에프. 호프만-라 로슈 아게 |
단일특이적 항체로부터 다중특이적 항체의 생체내 생성 방법
|
|
SG11202003980PA
(en)
|
2017-10-31 |
2020-05-28 |
Staten Biotechnology B V |
Anti-apoc3 antibodies and methods of use thereof
|
|
BR112020008393A2
(pt)
|
2017-11-01 |
2020-11-03 |
Chugai Seiyaku Kabushiki Kaisha |
variante e isoforma de anticorpos com atividade biológica reduzida
|
|
CN111344306A
(zh)
*
|
2017-11-02 |
2020-06-26 |
拜耳股份公司 |
结合alk-1和bmpr-2的双特异性抗体
|
|
CN117756946A
(zh)
*
|
2017-11-03 |
2024-03-26 |
莱蒂恩技术公司 |
用于用抗ror1免疫治疗来治疗癌症的组合物和方法
|
|
KR20200085828A
(ko)
|
2017-11-08 |
2020-07-15 |
젠코어 인코포레이티드 |
신규의 항-pd-1 서열을 사용한 이중특이적 및 단일특이적 항체
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
EP3713959A1
(en)
|
2017-11-21 |
2020-09-30 |
Innate Pharma |
Multispecific antigen binding proteins
|
|
IL274740B2
(en)
|
2017-11-30 |
2024-06-01 |
Regeneron Pharma |
Non-human animals comprising a humanized trkb locus
|
|
CN120571008A
(zh)
|
2017-12-13 |
2025-09-02 |
瑞泽恩制药公司 |
抗c5抗体组合及其用途
|
|
EP3728302A1
(en)
|
2017-12-19 |
2020-10-28 |
Xencor, Inc. |
Engineered il-2 fc fusion proteins
|
|
EP4495142A3
(en)
|
2017-12-22 |
2025-05-07 |
Argenx BVBA |
Bispecific antigen binding construct
|
|
CN111479618B
(zh)
|
2017-12-22 |
2022-08-02 |
瑞泽恩制药公司 |
用于表征药物产品杂质的系统和方法
|
|
US12247060B2
(en)
|
2018-01-09 |
2025-03-11 |
Marengo Therapeutics, Inc. |
Calreticulin binding constructs and engineered T cells for the treatment of diseases
|
|
TW201930344A
(zh)
|
2018-01-12 |
2019-08-01 |
美商安進公司 |
抗pd-1抗體及治療方法
|
|
JP2021510740A
(ja)
|
2018-01-24 |
2021-04-30 |
ゲンマブ ビー.ブイ. |
ポリペプチド変種およびそれらの用途
|
|
SG11202006379UA
(en)
|
2018-01-26 |
2020-07-29 |
Regeneron Pharma |
Human antibodies to influenza hemagglutinin
|
|
KR20200115485A
(ko)
|
2018-01-31 |
2020-10-07 |
리제너론 파마슈티칼스 인코포레이티드 |
약물 생성물 불순물을 특성화하기 위한 시스템 및 방법
|
|
US12180285B2
(en)
|
2018-02-01 |
2024-12-31 |
Memorial Sloan Kettering Cancer Center |
Antibodies to galectin-3 and methods of use thereof
|
|
TW202411650A
(zh)
|
2018-02-01 |
2024-03-16 |
美商再生元醫藥公司 |
治療性單株抗體之品質屬性的定量及模型化
|
|
TWI786265B
(zh)
|
2018-02-02 |
2022-12-11 |
美商再生元醫藥公司 |
用於表徵蛋白質二聚合之系統及方法
|
|
IL276464B2
(en)
|
2018-02-07 |
2026-01-01 |
Regeneron Pharma |
Methods and compositions for administering therapeutic protein
|
|
CN118772287A
(zh)
|
2018-02-08 |
2024-10-15 |
豪夫迈·罗氏有限公司 |
双特异性抗原结合分子和使用方法
|
|
GB201802487D0
(en)
|
2018-02-15 |
2018-04-04 |
Argenx Bvba |
Cytokine combination therapy
|
|
US12460270B2
(en)
|
2018-02-28 |
2025-11-04 |
Regeneron Pharmaceuticals, Inc. |
Systems and methods for identifying viral contaminants
|
|
US11248044B2
(en)
|
2018-03-01 |
2022-02-15 |
Regeneron Pharmaceuticals, Inc. |
Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor
|
|
WO2019178362A1
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
WO2019178364A2
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
BR112020015291B1
(pt)
|
2018-03-19 |
2023-09-26 |
Regeneron Pharmaceuticals, Inc |
Tampão de amostra de eletroforese aquoso, método para identificar contaminantes ou impurezas em uma amostra de fármaco proteico, e, kit
|
|
US12253490B2
(en)
|
2018-03-19 |
2025-03-18 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
US12259355B2
(en)
|
2018-03-19 |
2025-03-25 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
HUE070158T2
(hu)
|
2018-03-24 |
2025-05-28 |
Regeneron Pharma |
Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk
|
|
EP3773911A2
(en)
|
2018-04-04 |
2021-02-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
WO2019200022A1
(en)
|
2018-04-11 |
2019-10-17 |
Inhibrx, Inc. |
Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses
|
|
KR20210003814A
(ko)
|
2018-04-18 |
2021-01-12 |
젠코어 인코포레이티드 |
IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질
|
|
MX2020010910A
(es)
|
2018-04-18 |
2021-02-09 |
Xencor Inc |
Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos.
|
|
IL278244B2
(en)
|
2018-04-30 |
2026-01-01 |
Regeneron Pharma |
Antibodies and bispecific antigen-binding molecules that bind HER2 and/or APLP2, conjugates and uses thereof
|
|
EP3788074A1
(en)
|
2018-05-03 |
2021-03-10 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
|
TW202016125A
(zh)
|
2018-05-10 |
2020-05-01 |
美商再生元醫藥公司 |
用於定量及調節蛋白質黏度之系統與方法
|
|
CA3098805A1
(en)
|
2018-05-10 |
2019-11-14 |
Neuracle Science Co., Ltd. |
Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof
|
|
MA52626A
(fr)
|
2018-05-17 |
2021-03-24 |
Regeneron Pharma |
Anticorps anti-cd63, conjugués et leurs utilisations
|
|
WO2019232484A1
(en)
|
2018-06-01 |
2019-12-05 |
Compugen Ltd |
Anti-pvrig/anti-tigit bispecific antibodies and methods of use
|
|
TWI848953B
(zh)
|
2018-06-09 |
2024-07-21 |
德商百靈佳殷格翰國際股份有限公司 |
針對癌症治療之多特異性結合蛋白
|
|
MA52966A
(fr)
|
2018-06-19 |
2021-04-28 |
Regeneron Pharma |
Anticorps anti-facteur xii/xiia et leurs utilisations
|
|
TWI890661B
(zh)
|
2018-06-21 |
2025-07-21 |
美商再生元醫藥公司 |
用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法
|
|
MA52951A
(fr)
|
2018-06-22 |
2021-04-28 |
Genmab Holding B V |
Anticorps anti-cd37 et anticorps anti-cd20, compositions et méthodes d'utilisation de ceux-ci
|
|
CA3104390A1
(en)
|
2018-06-22 |
2019-12-26 |
Genmab A/S |
Method for producing a controlled mixture of two or more different antibodies
|
|
CN112424358B
(zh)
|
2018-06-26 |
2025-07-01 |
协和麒麟株式会社 |
与细胞粘附分子3结合的抗体
|
|
WO2020004490A1
(ja)
|
2018-06-26 |
2020-01-02 |
協和キリン株式会社 |
コンドロイチン硫酸プロテオグリカン-5に結合する抗体
|
|
EP3841124A4
(en)
|
2018-06-29 |
2022-03-23 |
ApitBio, Inc. |
ANTI-L1CAM ANTIBODIES AND USES THEREOF
|
|
CA3105448A1
(en)
|
2018-07-03 |
2020-01-09 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
IL316308A
(en)
*
|
2018-07-10 |
2024-12-01 |
Regeneron Pharma |
Modifying binding molecules to minimize pre-existing interactions
|
|
WO2020012038A1
(en)
|
2018-07-13 |
2020-01-16 |
Genmab A/S |
Trogocytosis-mediated therapy using cd38 antibodies
|
|
CN120865412A
(zh)
|
2018-07-13 |
2025-10-31 |
根马布股份公司 |
Cd38抗体变体及其用途
|
|
TWI902667B
(zh)
|
2018-07-13 |
2025-11-01 |
美商再生元醫藥公司 |
醣基化肽之偵測及定量
|
|
TWI838389B
(zh)
|
2018-07-19 |
2024-04-11 |
美商再生元醫藥公司 |
雙特異性抗-BCMAx抗-CD3抗體及其用途
|
|
TW202035451A
(zh)
|
2018-07-24 |
2020-10-01 |
美商英伊布里克斯公司 |
含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法
|
|
CN112639471B
(zh)
|
2018-08-13 |
2024-04-09 |
瑞泽恩制药公司 |
在模拟体内条件下的治疗性蛋白质选择
|
|
CN112601962A
(zh)
|
2018-08-17 |
2021-04-02 |
瑞泽恩制药公司 |
用于从头蛋白质测序的方法
|
|
US12152056B2
(en)
|
2018-08-17 |
2024-11-26 |
Regeneron Pharmaceuticals, Inc. |
Method and chromatography system for determining amount and purity of a multimeric protein
|
|
KR20210049863A
(ko)
|
2018-08-23 |
2021-05-06 |
리제너론 파아마슈티컬스, 인크. |
항-Fc 엡실론-R1 알파 (FCERIA) 항체, FCERIA 및 CD3에 결합하는 이중특이적 항원-결합 분자 및 이들의 용도
|
|
CN112218877B
(zh)
|
2018-08-27 |
2025-07-25 |
瑞泽恩制药公司 |
拉曼光谱在下游纯化中的应用
|
|
KR20210053816A
(ko)
|
2018-08-30 |
2021-05-12 |
리제너론 파마슈티칼스 인코포레이티드 |
단백질 복합체를 특성화하기 위한 방법
|
|
IL280875B2
(en)
|
2018-08-31 |
2024-12-01 |
Regeneron Pharma |
Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies
|
|
GB2576914A
(en)
|
2018-09-06 |
2020-03-11 |
Kymab Ltd |
Antigen-binding molecules comprising unpaired variable domains produced in mammals
|
|
MX2021003765A
(es)
|
2018-10-03 |
2021-07-15 |
Xencor Inc |
Proteínas il-12 de fusión a fc heterodimérico.
|
|
EP3860713A2
(en)
|
2018-10-03 |
2021-08-11 |
Staten Biotechnology B.V. |
Antibodies specific for human and cynomolgus apoc3 and methods of use thereof
|
|
MX2021003756A
(es)
|
2018-10-04 |
2021-08-11 |
Genmab Holding B V |
Composiciones farmaceuticas que comprenden anticuerpos anti cumulo de diferenciacion 37 (cd37) biespecificos.
|
|
EP3864049A1
(en)
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Pd-1 single domain antibodies and therapeutic compositions thereof
|
|
CA3115082A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
B7h3 single domain antibodies and therapeutic compositions thereof
|
|
US20210340273A1
(en)
|
2018-10-11 |
2021-11-04 |
Inhlbrx, inc. |
5t4 single domain antibodies and therapeutic compositions thereof
|
|
WO2020076977A2
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
Dll3 single domain antibodies and therapeutic compositions thereof
|
|
WO2020086406A2
(en)
|
2018-10-23 |
2020-04-30 |
Regeneron Pharmaceuticals, Inc. |
Anti-npr1 antibodies and uses thereof
|
|
EP3870976B1
(en)
|
2018-10-25 |
2023-11-29 |
Regeneron Pharmaceuticals, Inc. |
Methods for analysis of viral capsid protein composition
|
|
MX2021004732A
(es)
*
|
2018-10-26 |
2021-06-04 |
Teneobio Inc |
Anticuerpos de cadena pesada que se unen a cd38.
|
|
EP3874276B1
(en)
|
2018-10-31 |
2023-09-06 |
Regeneron Pharmaceuticals, Inc. |
Method and system of identifying and quantifying a protein
|
|
MA54139A
(fr)
|
2018-11-06 |
2021-09-15 |
BioNTech SE |
Formulation d'anticorps
|
|
JP7463366B2
(ja)
|
2018-11-20 |
2024-04-08 |
タケダ ワクチン,インコーポレイテッド |
新規の抗ジカウイルス抗体及びその使用
|
|
AU2019384790A1
(en)
|
2018-11-21 |
2021-03-18 |
Regeneron Pharmaceuticals, Inc. |
Anti-staphylococcus antibodies and uses thereof
|
|
US11249089B2
(en)
|
2018-12-12 |
2022-02-15 |
Regeneron Pharmaceuticals, Inc. |
System and method of analysis of a protein using liquid chromatography-mass spectrometry
|
|
TWI874341B
(zh)
|
2018-12-18 |
2025-03-01 |
美商健生生物科技公司 |
產生異二聚體抗體之方法
|
|
US11782023B2
(en)
|
2018-12-19 |
2023-10-10 |
Regeneron Pharmaceuticals, Inc. |
Ce-western applications for antibody development
|
|
GB201820687D0
(en)
|
2018-12-19 |
2019-01-30 |
Kymab Ltd |
Antagonists
|
|
ES2901683T3
(es)
|
2018-12-21 |
2022-03-23 |
Kymab Ltd |
Anticuerpo biespecífico FIXAXFX con cadena ligera común
|
|
CN113544145B
(zh)
*
|
2018-12-24 |
2024-12-17 |
首尔大学校产学协力团 |
中和1型干扰素的fc融合蛋白及其用途
|
|
BR112021012337A2
(pt)
|
2018-12-24 |
2021-09-14 |
Sanofi |
Proteínas de ligação multiespecíficas baseadas em pseudofab
|
|
CN117964756A
(zh)
|
2019-01-02 |
2024-05-03 |
纽洛可科学有限公司 |
抗序列相似家族19成员a5的抗体及其使用方法
|
|
IL284471B2
(en)
|
2019-01-16 |
2025-01-01 |
Regeneron Pharma |
Methods for identifying free thiols in proteins
|
|
US12463463B2
(en)
|
2019-01-28 |
2025-11-04 |
Ab Therapeutics, Inc. |
Bispecific antibodies and uses thereof
|
|
KR20210122803A
(ko)
|
2019-01-31 |
2021-10-12 |
리제너론 파아마슈티컬스, 인크. |
항체 전하 이질성의 고유 마이크로유체 ce-ms 분석
|
|
US12459991B2
(en)
|
2019-02-12 |
2025-11-04 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for using bispecific antibodies to bind complement and a target antigen
|
|
EP3927431A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
GB2597851B
(en)
|
2019-02-21 |
2024-05-29 |
Marengo Therapeutics Inc |
Antibody molecules that bind to NKP30 and uses thereof
|
|
EP3927746A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
EP3927744A1
(en)
|
2019-02-21 |
2021-12-29 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to t cell related cancer cells and uses thereof
|
|
CN114127112A
(zh)
|
2019-02-21 |
2022-03-01 |
马伦戈治疗公司 |
与t细胞结合的多功能分子及其治疗自身免疫性病症的用途
|
|
CN113874081A
(zh)
|
2019-02-26 |
2021-12-31 |
茵思博纳公司 |
高-亲和力抗-mertk抗体及其用途
|
|
AU2020232605A1
(en)
|
2019-03-01 |
2021-10-21 |
Xencor, Inc. |
Heterodimeric antibodies that bind ENPP3 and CD3
|
|
AU2020256225B9
(en)
|
2019-04-03 |
2025-04-10 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
|
|
WO2020206139A1
(en)
|
2019-04-04 |
2020-10-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized coagulation factor 12 locus
|
|
CA3134258A1
(en)
|
2019-04-10 |
2020-10-15 |
Regeneron Pharmaceuticals, Inc. |
Human antibodies that bind ret and methods of use thereof
|
|
US20220315661A1
(en)
|
2019-05-09 |
2022-10-06 |
Genmab B.V. |
Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
|
|
SG11202112349UA
(en)
|
2019-05-21 |
2021-12-30 |
Regeneron Pharma |
Methods for identifying and quantitating host cell protein
|
|
EP3801011A1
(en)
|
2019-06-04 |
2021-04-14 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
|
|
MX2021014893A
(es)
|
2019-06-05 |
2022-03-11 |
Regeneron Pharma |
Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos.
|
|
CN113966343A
(zh)
|
2019-06-11 |
2022-01-21 |
瑞泽恩制药公司 |
结合PcrV的抗PcrV抗体、包含抗PcrV抗体的组合物及其使用方法
|
|
US12545702B2
(en)
*
|
2019-06-13 |
2026-02-10 |
Regeneron Pharmaceuticals, Inc. |
Methods for removing undesired components during multistage chromatographic processes
|
|
WO2020257604A1
(en)
|
2019-06-21 |
2020-12-24 |
Regeneron Pharmaceuticals, Inc. |
Use of bispecific antigen-binding molecules that bind muc16 and cd3 in combination with 4-1bb co-stimulation
|
|
JP7743313B2
(ja)
|
2019-06-21 |
2025-09-24 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Psmaおよびcd3に結合する二重特異性抗原結合分子の4-1bb共刺激と組み合わせての使用
|
|
WO2021007150A1
(en)
|
2019-07-08 |
2021-01-14 |
Amgen Inc. |
Multispecific transthyretin immunoglobulin fusions
|
|
WO2021006328A1
(en)
|
2019-07-10 |
2021-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Claudin-6 binding molecules and uses thereof
|
|
GB201910900D0
(en)
*
|
2019-07-31 |
2019-09-11 |
Scancell Ltd |
Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
|
|
US12215148B2
(en)
|
2019-08-08 |
2025-02-04 |
Regeneron Pharmaceuticals, Inc. |
Antigen binding molecule formats
|
|
CR20220054A
(es)
|
2019-08-15 |
2022-06-06 |
Janssen Biotech Inc |
Materiales y métodos para fragmentos variables de cadena única mejorado
|
|
TWI890689B
(zh)
|
2019-08-15 |
2025-07-21 |
美商再生元醫藥公司 |
用於細胞靶向之多特異性抗原結合分子及其用途
|
|
AU2020335928A1
(en)
|
2019-08-30 |
2022-02-17 |
Agenus Inc. |
Anti-CD96 antibodies and methods of use thereof
|
|
US12297451B1
(en)
|
2019-10-25 |
2025-05-13 |
Regeneron Pharmaceuticals, Inc. |
Cell culture medium
|
|
BR112022007923A2
(pt)
|
2019-10-28 |
2022-07-26 |
Regeneron Pharma |
Anticorpo recombinante isolado ou fragmento de ligação ao antígeno deste, composição farmacêutica, molécula de polinucleotídeo, vetor, célula, e, método para prevenir, tratar ou melhorar pelo menos um sintoma da infecção por influenza
|
|
TW202134277A
(zh)
|
2019-11-05 |
2021-09-16 |
美商再生元醫藥公司 |
N—端scFv多特異性結合分子
|
|
US20220411529A1
(en)
|
2019-11-06 |
2022-12-29 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
MX2022006236A
(es)
|
2019-11-25 |
2022-06-22 |
Regeneron Pharma |
Formulaciones de liberacion sostenida con emulsiones no acuosas.
|
|
AU2020395122A1
(en)
|
2019-12-02 |
2022-06-09 |
Regeneron Pharmaceuticals, Inc. |
Peptide-MHC II protein constructs and uses thereof
|
|
MX2022006714A
(es)
|
2019-12-06 |
2022-08-08 |
Regeneron Pharma |
Métodos de tratamiento del mieloma múltiple con anticuerpos anti-bcma x anti-cd3 bisespecíficos.
|
|
EP3931303A1
(en)
|
2019-12-06 |
2022-01-05 |
Regeneron Pharmaceuticals, Inc. |
Anti-vegf protein compositions and methods for producing the same
|
|
CA3164226A1
(en)
|
2019-12-11 |
2021-06-17 |
Cilag Gmbh International |
Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof
|
|
TW202136317A
(zh)
|
2019-12-20 |
2021-10-01 |
美商再生元醫藥公司 |
新穎之il2促效劑及其使用方法(二)
|
|
BR112022011993A2
(pt)
|
2019-12-26 |
2022-09-20 |
Abl Bio Inc |
Método para purificar peptídeo biologicamente ativo usando cromatografia de afinidade de proteína a
|
|
EP4084823A4
(en)
|
2020-01-03 |
2024-05-15 |
Marengo Therapeutics, Inc. |
ANTI-TCR ANTIBODY MOLECULES AND THEIR USES
|
|
WO2021138407A2
(en)
|
2020-01-03 |
2021-07-08 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to cd33 and uses thereof
|
|
AU2021205910A1
(en)
|
2020-01-08 |
2022-09-01 |
Regeneron Pharmaceuticals, Inc. |
Use of amino acids to enhance signal in mass spectral analyses
|
|
KR20220130724A
(ko)
|
2020-01-16 |
2022-09-27 |
젠맵 에이/에스 |
Cd38 항체의 제제 및 그의 용도
|
|
KR102544013B1
(ko)
|
2020-01-21 |
2023-06-19 |
리제너론 파마슈티칼스 인코포레이티드 |
당질화된 단백질의 전기영동을 위한 탈당질화 방법
|
|
EP4097484A1
(en)
|
2020-01-27 |
2022-12-07 |
Regeneron Pharmaceuticals, Inc. |
Tandem mass tag multiplexed quantitation of post-translational modifications of proteins
|
|
US12250931B2
(en)
|
2020-01-28 |
2025-03-18 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified mouse with a humanized PNPLA3 gene and methods of use
|
|
KR20220148175A
(ko)
|
2020-01-29 |
2022-11-04 |
인히브릭스, 인크. |
Cd28 단일 도메인 항체 및 이의 다가 및 다중특이적 구조체
|
|
KR20220133942A
(ko)
|
2020-01-30 |
2022-10-05 |
리제너론 파아마슈티컬스, 인크. |
네이티브 액체 크로마토그래피-질량 분석용 플랫폼
|
|
CN115210574A
(zh)
|
2020-01-31 |
2022-10-18 |
瑞泽恩制药公司 |
通过液相色谱-质谱法进行高置信度化合物鉴定
|
|
EP4099821A1
(en)
|
2020-02-07 |
2022-12-14 |
Regeneron Pharmaceuticals, Inc. |
<smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
|
|
KR20220140802A
(ko)
|
2020-02-11 |
2022-10-18 |
리제너론 파아마슈티컬스, 인크. |
항-acvr1 항체 및 이의 용도
|
|
WO2021190980A1
(en)
|
2020-03-22 |
2021-09-30 |
Quadrucept Bio Limited |
Multimers for viral strain evolution
|
|
WO2021195079A1
(en)
|
2020-03-23 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
CA3173162A1
(en)
|
2020-03-25 |
2021-09-30 |
Eli Lilly And Company |
Multispecific binding proteins and methods of developing the same
|
|
IL296514A
(en)
|
2020-03-30 |
2022-11-01 |
Univ Mie |
Bispecific antibody
|
|
IL297024A
(en)
|
2020-04-14 |
2022-12-01 |
Regeneron Pharma |
Ultraviolet monitoring of chromatography performance using orthogonal partial least squares
|
|
CA3180321A1
(en)
|
2020-04-24 |
2021-10-28 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to t cell related cancer cells and uses thereof
|
|
WO2021226444A2
(en)
|
2020-05-08 |
2021-11-11 |
Regeneron Pharmaceuticals, Inc. |
Vegf traps and mini-traps and methods for treating ocular disorders and cancer
|
|
WO2021228904A1
(en)
|
2020-05-11 |
2021-11-18 |
Academisch Medisch Centrum |
Neutralizing antibodies binding to the spike protein of sars-cov-2 suitable for use in the treatment of covid-19, compositions comprising the same and uses thereof
|
|
KR20230009430A
(ko)
|
2020-05-12 |
2023-01-17 |
리제너론 파아마슈티컬스, 인크. |
신규 il10 효능제 및 그의 사용 방법
|
|
IL298099A
(en)
|
2020-05-12 |
2023-01-01 |
Regeneron Pharma |
Anti-glp1r antagonist antibodies and methods of use thereof
|
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
|
EP4171215A2
(en)
|
2020-06-26 |
2023-05-03 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ace2 locus
|
|
WO2022018294A1
(en)
|
2020-07-23 |
2022-01-27 |
Genmab B.V. |
A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
|
|
LT4200018T
(lt)
|
2020-08-18 |
2025-03-25 |
Cephalon Llc |
Anti-par-2 antikūnai ir jų panaudojimo būdas
|
|
JP7773528B2
(ja)
|
2020-08-19 |
2025-11-19 |
ゼンコア インコーポレイテッド |
抗cd28組成物
|
|
CA3189147A1
(en)
|
2020-08-20 |
2022-02-24 |
David Glass |
Methods for preventing and treating cardiac dysfunction and covid-19 with activin a antagonists
|
|
GB2616128A
(en)
|
2020-08-26 |
2023-08-30 |
Marengo Therapeutics Inc |
Antibody molecules that bind to NKp30 and uses thereof
|
|
JP2023540248A
(ja)
|
2020-08-26 |
2023-09-22 |
マレンゴ・セラピューティクス,インコーポレーテッド |
Trbc1またはtrbc2を検出する方法
|
|
WO2022046920A2
(en)
|
2020-08-26 |
2022-03-03 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
CA3192999A1
(en)
|
2020-08-31 |
2022-03-03 |
Regeneron Pharmaceuticals, Inc. |
Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants
|
|
EP4211155A1
(en)
|
2020-09-11 |
2023-07-19 |
Regeneron Pharmaceuticals, Inc. |
Identification and production of antigen-specific antibodies
|
|
CN116348495A
(zh)
|
2020-09-18 |
2023-06-27 |
瑞泽恩制药公司 |
结合cd38和/或cd28的抗原结合分子及其用途
|
|
MX2023003749A
(es)
|
2020-10-02 |
2023-04-24 |
Genmab As |
Anticuerpos capaces de unirse al receptor huerfano 2 similar a tirosina-cinasa receptora (ror2) y anticuerpos biespecificos que se unen a ror2 y al cumulo de diferenciacion 3 (cd3).
|
|
JP2023547795A
(ja)
|
2020-10-15 |
2023-11-14 |
ユーシービー バイオファルマ エスアールエル |
Cd45を多量体化する結合分子
|
|
NZ797493A
(en)
|
2020-10-22 |
2024-05-31 |
Regeneron Pharma |
Anti-fgfr2 antibodies and methods of use thereof
|
|
CA3196191A1
(en)
|
2020-11-04 |
2022-05-12 |
Chi-Chung Li |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
|
|
IL302400A
(en)
|
2020-11-04 |
2023-06-01 |
Genentech Inc |
Subcutaneous dosing of bispecific anti-CD20/anti-CD3 antibodies
|
|
CA3196539A1
(en)
|
2020-11-04 |
2022-05-12 |
Chi-Chung Li |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
WO2022100613A1
(zh)
|
2020-11-10 |
2022-05-19 |
上海齐鲁制药研究中心有限公司 |
针对密蛋白18a2和cd3的双特异性抗体及其应用
|
|
EP4251128A1
(en)
|
2020-11-25 |
2023-10-04 |
Regeneron Pharmaceuticals, Inc. |
Sustained release formulations using non-aqueous membrane emulsification
|
|
CN114539416B
(zh)
*
|
2020-11-26 |
2024-11-08 |
盛禾(中国)生物制药有限公司 |
一种双特异性抗体的层析纯化工艺
|
|
WO2022133135A1
(en)
|
2020-12-17 |
2022-06-23 |
Regeneron Pharmaceuticals, Inc. |
Fabrication of protein-encapsulating microgels
|
|
CA3202629A1
(en)
|
2020-12-18 |
2022-06-23 |
Regeneron Pharmaceuticals, Inc. |
Immunoglobulin proteins that bind to npr1 agonists
|
|
CN116745609A
(zh)
|
2020-12-20 |
2023-09-12 |
瑞泽恩制药公司 |
鉴定生物分子中乱序二硫键的方法
|
|
MX2023008190A
(es)
*
|
2021-01-11 |
2023-09-28 |
Adimab Llc |
Variantes de dominios ch3 genomodificados para la heterodimerización de ch3 preferencial, anticuerpos multi específicos que los comprenden, y sus métodos de fabricación.
|
|
CN116761880A
(zh)
|
2021-01-20 |
2023-09-15 |
瑞泽恩制药公司 |
改进细胞培养物中的蛋白质滴度的方法
|
|
AR124707A1
(es)
|
2021-01-28 |
2023-04-26 |
Talem Therapeutics Llc |
Anticuerpos antiglicoproteína de espiga y su uso terapéutico
|
|
SI4284512T1
(sl)
|
2021-01-28 |
2025-06-30 |
Regeneron Pharmaceuticals, Inc. |
Sestavki in postopki za zdravljenje sindroma sproščanja citokinov
|
|
KR102661163B1
(ko)
|
2021-02-04 |
2024-04-26 |
주식회사 지뉴브 |
항 pd-1 항체 및 그의 용도
|
|
WO2022184659A1
(en)
|
2021-03-01 |
2022-09-09 |
Quadrucept Bio Limited |
Antibody domains & multimers
|
|
CA3207883A1
(en)
|
2021-03-03 |
2022-09-09 |
Xiaobin Xu |
Systems and methods for quantifying and modifying protein viscosity
|
|
CA3212665A1
(en)
|
2021-03-09 |
2022-09-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cldn6
|
|
KR20230154311A
(ko)
|
2021-03-10 |
2023-11-07 |
젠코어 인코포레이티드 |
Cd3 및 gpc3에 결합하는 이종이량체 항체
|
|
KR20230162013A
(ko)
|
2021-03-26 |
2023-11-28 |
이나뜨 파르마 에스.에이. |
Nk 세포 관여를 위해 사이토카인에 융합된 nkp46-결합 부위, 암 항원 결합 부위를 포함하는 다중특이적 단백질
|
|
IL305818A
(en)
|
2021-03-29 |
2023-11-01 |
Daiichi Sankyo Co Ltd |
Multispecific stable compound and its use
|
|
AR125255A1
(es)
|
2021-04-02 |
2023-06-28 |
Regeneron Pharma |
Métodos de predicción y modulación de la glicación de una proteína
|
|
JP2024514530A
(ja)
|
2021-04-02 |
2024-04-02 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
切断型cdcp1に対する抗体およびその使用
|
|
KR20240004462A
(ko)
|
2021-04-08 |
2024-01-11 |
마렝고 테라퓨틱스, 인크. |
Tcr에 결합하는 다기능성 분자 및 이의 용도
|
|
US20240174752A1
(en)
|
2021-04-27 |
2024-05-30 |
Amgen Inc. |
Modulating product quality of asymmetric multispecific antibodies through the use of temperature
|
|
MX2023012974A
(es)
|
2021-05-04 |
2023-11-15 |
Regeneron Pharma |
Agonistas multiespecificos de receptores del fgf21 y sus usos.
|
|
CN117597365A
(zh)
|
2021-05-04 |
2024-02-23 |
再生元制药公司 |
多特异性fgf21受体激动剂及其应用
|
|
WO2022241235A1
(en)
|
2021-05-14 |
2022-11-17 |
Genentech, Inc. |
Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
|
|
CN117412767A
(zh)
|
2021-05-25 |
2024-01-16 |
雪绒花免疫公司 |
C-x-c基序趋化因子受体6(cxcr6)结合分子及其使用方法
|
|
AU2022286340A1
(en)
|
2021-06-01 |
2024-01-04 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
WO2022258691A1
(en)
|
2021-06-09 |
2022-12-15 |
Innate Pharma |
Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
|
|
MX2023014645A
(es)
|
2021-06-09 |
2024-01-31 |
Innate Pharma |
Proteinas acopladoras de celulas nk de union a nkp46 especificas de cd20.
|
|
WO2022258678A1
(en)
|
2021-06-09 |
2022-12-15 |
Innate Pharma |
Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
|
|
CN117616050A
(zh)
|
2021-06-09 |
2024-02-27 |
先天制药公司 |
与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质
|
|
WO2022263357A1
(en)
|
2021-06-14 |
2022-12-22 |
Argenx Iip Bv |
Anti-il-9 antibodies and methods of use thereof
|
|
US12448451B2
(en)
|
2021-06-25 |
2025-10-21 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-CTLA-4 antibody and use thereof
|
|
TW202321282A
(zh)
|
2021-07-19 |
2023-06-01 |
美商再生元醫藥公司 |
Il12受體促效劑及其使用方法
|
|
TW202322850A
(zh)
*
|
2021-08-05 |
2023-06-16 |
美商美國禮來大藥廠 |
抗體最佳化
|
|
JP2024534787A
(ja)
|
2021-08-16 |
2024-09-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
新規なil27受容体アゴニスト及びその使用方法
|
|
US20240360233A1
(en)
|
2021-08-27 |
2024-10-31 |
Board Of Regents, The University Of Texas System |
Anti-tslpr (crlf2) antibodies
|
|
EP4399227A1
(en)
|
2021-09-06 |
2024-07-17 |
Genmab A/S |
Antibodies capable of binding to cd27, variants thereof and uses thereof
|
|
WO2023039457A1
(en)
|
2021-09-08 |
2023-03-16 |
Regeneron Pharmaceuticals, Inc. |
A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins
|
|
KR20240107104A
(ko)
|
2021-11-04 |
2024-07-08 |
리제너론 파마슈티칼스 인코포레이티드 |
변형된 cacng1 유전자좌를 포함하는 비인간 동물
|
|
WO2023086812A1
(en)
|
2021-11-11 |
2023-05-19 |
Regeneron Pharmaceuticals, Inc. |
Cd20-pd1 binding molecules and methods of use thereof
|
|
IL312813A
(en)
|
2021-11-24 |
2024-07-01 |
Regeneron Pharma |
Methods for treating cancer using bispecific antibodies against CD3 and MUC16 and antibodies against CTLA-4
|
|
IL312728A
(en)
|
2021-11-30 |
2024-07-01 |
Daiichi Sankyo Co Ltd |
Protease-cleavable masked antibodies
|
|
IL313265A
(en)
|
2021-12-06 |
2024-08-01 |
Regeneron Pharma |
Antagonistic antibodies against NPR1 and methods of using them
|
|
KR20240117571A
(ko)
|
2021-12-08 |
2024-08-01 |
리제너론 파마슈티칼스 인코포레이티드 |
돌연변이 마이오실린 질환 모델 및 이의 용도
|
|
US20250049006A1
(en)
|
2021-12-20 |
2025-02-13 |
C/O Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
|
KR20240130137A
(ko)
|
2022-01-07 |
2024-08-28 |
리제너론 파아마슈티컬스, 인크. |
이중특이적 항-MUC16 x 항-CD3 항체 단독으로 또는 항-PD-1 항체와의 조합으로 재발성 난소암을 치료하는 방법
|
|
US20250084169A1
(en)
|
2022-01-12 |
2025-03-13 |
Biomolecular Holdings Llc |
Nk/monocyte engagers
|
|
TW202337900A
(zh)
|
2022-01-12 |
2023-10-01 |
美商再生元醫藥公司 |
改良使用親和層析的異二聚蛋白質自雜質之解析的方法
|
|
US20250194571A1
(en)
|
2022-02-07 |
2025-06-19 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
|
EP4477674A1
(en)
|
2022-02-09 |
2024-12-18 |
Daiichi Sankyo Company, Limited |
Environmentally responsive masked antibody and use thereof
|
|
JP2025506095A
(ja)
|
2022-02-11 |
2025-03-07 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
4rタウ標的化剤をスクリーニングするための組成物及び方法
|
|
EP4482531A1
(en)
|
2022-02-23 |
2025-01-01 |
Bright Peak Therapeutics AG |
Immune antigen specific il-18 immunocytokines and uses thereof
|
|
US12365743B2
(en)
|
2022-02-23 |
2025-07-22 |
Xencor, Inc. |
Anti-CD28 x anti-PSMA antibodies
|
|
WO2023164640A1
(en)
|
2022-02-24 |
2023-08-31 |
Xencor, Inc. |
Anti-cd28 x anti-trop2 antibodies
|
|
US20230340128A1
(en)
|
2022-02-24 |
2023-10-26 |
Xencor, Inc. |
Anti-cd28 x anti-msln antibodies
|
|
TW202400228A
(zh)
|
2022-02-25 |
2024-01-01 |
美商再生元醫藥公司 |
減輕細胞激素釋放症候群的給藥方案
|
|
CN119031932A
(zh)
|
2022-03-16 |
2024-11-26 |
第一三共株式会社 |
多特异性分子和免疫检查点抑制剂的组合
|
|
JP2025509567A
(ja)
|
2022-03-17 |
2025-04-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
再発性類上皮肉腫を、二重特異性抗MUC16x 抗CD3抗体単独で、または抗PD-1抗体と組み合わせて治療する方法
|
|
WO2023196903A1
(en)
|
2022-04-06 |
2023-10-12 |
Regeneron Pharmaceuticals, Inc. |
Bispecific antigen-binding molecules that bind and cd3 and tumor associated antigens (taas) and uses thereof
|
|
US20230357446A1
(en)
|
2022-04-11 |
2023-11-09 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for universal tumor cell killing
|
|
EP4514981A2
(en)
|
2022-04-29 |
2025-03-05 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
IL316892A
(en)
|
2022-05-11 |
2025-01-01 |
Regeneron Pharma |
Multispecific proprotein binding molecules and their uses
|
|
AU2023269545A1
(en)
|
2022-05-12 |
2024-11-14 |
BioNTech SE |
Binding agents capable of binding to cd27 in combination therapy
|
|
AU2023269546A1
(en)
|
2022-05-12 |
2024-11-14 |
BioNTech SE |
Binding agents capable of binding to cd27 in combination therapy
|
|
US20250304714A1
(en)
|
2022-05-16 |
2025-10-02 |
Regeneron Pharmaceuticals, Inc. |
Methods of Treating Metastatic Castration-Resistant Prostate Cancer with Bispecific Anti-PSMA x Anti-CD3 Antibodies Alone or in Combination with Anti-PD-1 Antibodies
|
|
KR20250011926A
(ko)
|
2022-05-18 |
2025-01-22 |
리제너론 파마슈티칼스 인코포레이티드 |
Cd38 및 4-1bb에 결합하는 다중특이적 항원 결합 분자, 및 이의 용도
|
|
EP4532529A1
(en)
|
2022-05-27 |
2025-04-09 |
Regeneron Pharmaceuticals, Inc. |
Interleukin-2 proproteins and uses thereof
|
|
US20230391844A1
(en)
|
2022-06-04 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Interleukin-2 proproteins and uses thereof
|
|
CN119584978A
(zh)
|
2022-06-07 |
2025-03-07 |
再生元制药公司 |
用于调节t细胞活性的多特异性分子及其用途
|
|
WO2024020199A1
(en)
|
2022-07-21 |
2024-01-25 |
Regeneron Pharmaceuticals, Inc. |
Native microfluidic ce-ms analysis of antibody charge heterogeneity
|
|
AU2023312978A1
(en)
|
2022-07-29 |
2025-03-20 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:payload fusions and methods of use thereof
|
|
AU2023314808A1
(en)
|
2022-07-29 |
2025-03-20 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
|
CN120112164A
(zh)
|
2022-07-29 |
2025-06-06 |
瑞泽恩制药公司 |
包含修饰的转铁蛋白受体基因座的非人动物
|
|
WO2024030453A1
(en)
|
2022-08-02 |
2024-02-08 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies in combination with anti-pd-1 antibodies
|
|
JP2025529805A
(ja)
|
2022-08-18 |
2025-09-09 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
インターフェロンプロタンパク質及びその使用
|
|
US20240067691A1
(en)
|
2022-08-18 |
2024-02-29 |
Regeneron Pharmaceuticals, Inc. |
Interferon receptor agonists and uses thereof
|
|
CN119998330A
(zh)
|
2022-09-15 |
2025-05-13 |
艾维迪治疗知识产权有限公司 |
用于刺激nk细胞的多特异性抗原结合蛋白及其用途
|
|
WO2024073679A1
(en)
|
2022-09-29 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
|
|
KR20250080896A
(ko)
|
2022-10-10 |
2025-06-05 |
리제너론 파아마슈티컬스, 인크. |
고형 장기 이식이 필요한 대상체에서 동종항체 수치를 감소시키는 방법
|
|
EP4604988A1
(en)
|
2022-10-21 |
2025-08-27 |
Diagonal Therapeutics Inc. |
Heteromeric agonistic antibodies to il-18 receptor
|
|
WO2024092031A1
(en)
|
2022-10-25 |
2024-05-02 |
Seismic Therapeutic, Inc. |
VARIANT IgG FC POLYPEPTIDES AND USES THEREOF
|
|
EP4608865A1
(en)
|
2022-10-27 |
2025-09-03 |
Regeneron Pharmaceuticals, Inc. |
Anti-acvr1 antibodies and their use in the treatment of trauma-induced heterotopic ossification
|
|
EP4612177A1
(en)
|
2022-10-31 |
2025-09-10 |
Genmab A/S |
Cd38 antibodies and uses thereof
|
|
EP4612184A1
(en)
|
2022-11-04 |
2025-09-10 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
WO2024102948A1
(en)
|
2022-11-11 |
2024-05-16 |
Celgene Corporation |
Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
US20240158515A1
(en)
|
2022-11-14 |
2024-05-16 |
Regeneron Pharmaceuticals, Inc. |
Anti-fgfr3 antibodies and antigen-binding fragments and methods of use thereof
|
|
WO2024123698A1
(en)
|
2022-12-08 |
2024-06-13 |
Regeneron Pharmaceuticals, Inc. |
Methods to characterizing a fragment crystallizable domain of a bispecific antibody
|
|
EP4634220A2
(en)
|
2022-12-16 |
2025-10-22 |
Regeneron Pharmaceuticals, Inc. |
Antigen-binding molecules that bind to aav particles and uses
|
|
US12195546B2
(en)
|
2022-12-19 |
2025-01-14 |
Sanofi |
CD28/OX40 bispecific antibodies
|
|
US20240252601A1
(en)
|
2022-12-23 |
2024-08-01 |
Regeneron Pharmaceuticals, Inc. |
Ace2 fusion proteins and uses thereof
|
|
US20240270836A1
(en)
|
2023-01-13 |
2024-08-15 |
Regeneron Pharmaceuticals, Inc. |
Il12 receptor agonists and methods of use thereof
|
|
WO2024152014A1
(en)
|
2023-01-13 |
2024-07-18 |
Regeneron Pharmaceuticals, Inc. |
Fgfr3 binding molecules and methods of use thereof
|
|
KR20250151402A
(ko)
|
2023-01-20 |
2025-10-21 |
인베티엑스 인코포레이티드 |
반려 동물에서 사용하기 위한 이중특이적 결합제
|
|
KR20250150011A
(ko)
|
2023-02-13 |
2025-10-17 |
리제너론 파마슈티칼스 인코포레이티드 |
항-인간 cacng1 항체를 이용한 근육 관련 장애 치료
|
|
IL322545A
(en)
|
2023-02-17 |
2025-10-01 |
Regeneron Pharma |
Induced NK cells responding to bispecific CD3/TAA antibodies
|
|
JP2026507138A
(ja)
|
2023-02-28 |
2026-02-27 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
多価抗スパイクタンパク質結合分子およびその使用
|
|
JP2026507123A
(ja)
|
2023-02-28 |
2026-02-27 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
T細胞活性化剤およびその使用方法
|
|
US20250043001A1
(en)
|
2023-03-14 |
2025-02-06 |
Xencor, Inc. |
Anti-cd28 compositions
|
|
EP4680632A2
(en)
|
2023-03-17 |
2026-01-21 |
Oxitope Pharma B.V. |
Anti-phosphocholine antibodies and methods of use thereof
|
|
WO2024194685A2
(en)
|
2023-03-17 |
2024-09-26 |
Oxitope Pharma B.V. |
Anti-phosphocholine antibodies and methods of use thereof
|
|
AR132178A1
(es)
|
2023-03-22 |
2025-06-04 |
Salubris Biotherapeutics Inc |
Dominios de unión al antígeno anti-5t4, conjugados anticuerpo-fármaco, y métodos de uso de los mismos
|
|
AU2024254039A1
(en)
|
2023-04-07 |
2025-10-02 |
Diagonal Therapeutics Inc. |
Hinge-modified bispecific antibodies
|
|
KR20250168499A
(ko)
|
2023-04-07 |
2025-12-02 |
다이애고널 테라퓨틱스 인코포레이티드 |
액티빈 a 수용체 유사 유형 1(alk1)에 대한 이중 특이적 효현성 항체
|
|
CN121487967A
(zh)
|
2023-04-14 |
2026-02-06 |
Xencor股份有限公司 |
抗cd28 x抗enpp3抗体
|
|
CN121311507A
(zh)
|
2023-04-14 |
2026-01-09 |
Xencor股份有限公司 |
抗cd28 x抗trop2抗体
|
|
TW202508625A
(zh)
|
2023-05-01 |
2025-03-01 |
美商再生元醫藥公司 |
使用苯酚或苯甲醇之多劑量抗體藥物產品
|
|
AU2024265507A1
(en)
|
2023-05-02 |
2025-10-30 |
Regeneron Pharmaceuticals, Inc. |
Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells
|
|
US20240400687A1
(en)
|
2023-05-10 |
2024-12-05 |
Regeneron Pharmaceuticals, Inc. |
Cd20-pd1 binding molecules and methods of use thereof
|
|
TW202509071A
(zh)
|
2023-05-12 |
2025-03-01 |
丹麥商珍美寶股份有限公司 |
能夠與ox40結合之抗體、其變異體及其用途
|
|
AU2024274130A1
(en)
|
2023-05-12 |
2026-01-08 |
Regeneron Pharmaceuticals, Inc. |
Interferon receptor antagonists and uses thereof
|
|
AU2024276812A1
(en)
|
2023-05-19 |
2025-11-06 |
Diagonal Therapeutics Inc. |
Bispecific agonistic antibodies to il12 receptor
|
|
CN121263062A
(zh)
|
2023-06-08 |
2026-01-02 |
瑞泽恩制药公司 |
阿尔茨海默病淀粉样β斑块病变快速发作的动物模型
|
|
WO2024251884A1
(en)
|
2023-06-09 |
2024-12-12 |
Innate Pharma |
Nk cell engager proteins comprising anti-cd20 and ant-nkp46 antibody, linked to il-2 in treatment of r/r b-nhl
|
|
US20250011449A1
(en)
|
2023-06-11 |
2025-01-09 |
Regeneron Pharmaceuticals, Inc. |
Circularized antibody molecules
|
|
AU2024305352A1
(en)
|
2023-06-12 |
2025-12-04 |
Amgen Inc. |
Lymphotoxin beta receptor agonist binding proteins
|
|
KR20260026068A
(ko)
|
2023-06-16 |
2026-02-25 |
리제너론 파아마슈티컬스, 인크. |
Cd40 x cd40 이중특이적 항원 결합 분자 및 이의 용도
|
|
CN121568720A
(zh)
|
2023-07-10 |
2026-02-24 |
瑞泽恩制药公司 |
抗人类cacng1抗体-药物缀合物及其用途
|
|
WO2025014913A1
(en)
|
2023-07-10 |
2025-01-16 |
Regeneron Pharmaceuticals, Inc. |
Bispecific pd-l1xcd28 antibodies and methods of use thereof
|
|
TW202519547A
(zh)
|
2023-07-10 |
2025-05-16 |
美商再生元醫藥公司 |
雙特異性PD-L1x4-1BB抗體及其使用方法
|
|
CN121568964A
(zh)
|
2023-07-19 |
2026-02-24 |
里珍纳龙药品有限公司 |
抗因子XII/XIIa抗体及其用途
|
|
AR133384A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Anti-tfr:esfingomielinasa ácida para el tratamiento de la deficiencia de esfingomielinasa ácida
|
|
AU2024317483A1
(en)
|
2023-07-28 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
|
WO2025030044A1
(en)
|
2023-08-02 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating clear cell renal cell carcinoma with bispecific anti-psma x anti-cd28 antibodies
|
|
CN121604974A
(zh)
|
2023-08-02 |
2026-03-03 |
瑞泽恩制药公司 |
用双特异性抗psma x抗CD28抗体治疗转移性去势抵抗性前列腺癌的方法
|
|
WO2025041097A1
(en)
|
2023-08-23 |
2025-02-27 |
Bright Peak Therapeutics Ag |
Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof
|
|
WO2025049591A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Anti-cxcr4 antibodies and uses thereof
|
|
AR133676A1
(es)
|
2023-08-28 |
2025-10-22 |
Xencor Inc |
Combiterapia de anti-cd20 x anti-cd28
|
|
WO2025090519A1
(en)
|
2023-10-23 |
2025-05-01 |
Diagonal Therapeutics Inc. |
Heteromeric agonistic antibodies to il-18 receptor
|
|
WO2025090973A2
(en)
|
2023-10-27 |
2025-05-01 |
Xencor, Inc. |
Anti-trop2 x anti-pdl1 x anti-cd28 antibodies
|
|
WO2025106469A1
(en)
|
2023-11-14 |
2025-05-22 |
Regeneron Pharmaceuticals, Inc. |
Engineered heavy chain variable domains and uses thereof
|
|
US20250163468A1
(en)
|
2023-11-21 |
2025-05-22 |
Regeneron Pharmaceuticals, Inc. |
Covalently surface modified adeno-associated virus production by in vitro conjugation, and purification of covalently surface modified adeno-associated virus
|
|
TW202539732A
(zh)
|
2023-11-29 |
2025-10-16 |
美商再生元醫藥公司 |
以雙特異性抗muc16×抗cd28抗體與抗pd-1抗體之組合或與雙特異性抗muc16×抗cd3抗體之組合治療復發性卵巢癌及子宮內膜癌之方法
|
|
TW202540189A
(zh)
|
2023-11-30 |
2025-10-16 |
德商生物新技術公司 |
在組合療法中能夠結合ox40之抗體
|
|
US20250179137A1
(en)
|
2023-12-05 |
2025-06-05 |
Regeneron Pharmaceuticals, Inc. |
Il18 receptor agonists and methods of use thereof
|
|
GB202318820D0
(en)
|
2023-12-08 |
2024-01-24 |
UCB Biopharma SRL |
Antibodies
|
|
TW202542187A
(zh)
|
2023-12-12 |
2025-11-01 |
美商再生元醫藥公司 |
以雙特異性抗muc16x抗cd3抗體單獨或與抗pd-1抗體組合治療子宮內膜癌之方法
|
|
WO2025133707A1
(en)
|
2023-12-19 |
2025-06-26 |
Vectory Therapeutics B.V. |
Anti-tdp-43 antibodies and uses thereof
|
|
WO2025151806A1
(en)
|
2024-01-11 |
2025-07-17 |
Regeneron Pharmaceuticals, Inc. |
P75 neurotrophin receptor (p75ntr)-binding proteins and p75ntr-mediated delivery to the nervous system
|
|
WO2025149633A1
(en)
|
2024-01-12 |
2025-07-17 |
Laigo Bio B.V. |
Bispecific antigen binding proteins
|
|
TW202540428A
(zh)
|
2024-01-26 |
2025-10-16 |
美商雷傑納榮製藥公司 |
使用漿細胞耗乏劑及/或b細胞耗乏劑遏制宿主抗aav抗體反應且實現aav轉導及重複給藥的方法及組成物
|
|
US20250242018A1
(en)
|
2024-01-26 |
2025-07-31 |
Regeneron Pharmaceuticals, Inc. |
Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
|
|
WO2025171124A1
(en)
|
2024-02-07 |
2025-08-14 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating prostate cancer with bispecific anti-psma x anti-cd3 antibodies and bispecific anti-psma x anti-cd28 antibodies
|
|
US20250276092A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025184603A2
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration
|
|
WO2025191136A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
|
|
WO2025191137A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Conjugates of trop2-specific antigen binding proteins and cytokines
|
|
WO2025191133A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Il-21 muteins, fusion proteins comprising the same and uses thereof
|
|
US20250297006A1
(en)
|
2024-03-20 |
2025-09-25 |
Regeneron Pharmaceuticals, Inc. |
Masked Multispecific Antigen-Binding Molecules with Cleavable Linkers
|
|
WO2025199243A1
(en)
|
2024-03-20 |
2025-09-25 |
Regeneron Pharmaceuticals, Inc. |
Trivalent multispecific binding molecules and methods of use thereof
|
|
WO2025213061A2
(en)
|
2024-04-04 |
2025-10-09 |
Ethyreal Bio, Inc. |
Anti-tshr antibodies and uses thereof
|
|
WO2025221736A2
(en)
|
2024-04-15 |
2025-10-23 |
Janssen Biotech, Inc. |
Ltbr binding molecules and uses thereof
|
|
WO2025240335A1
(en)
|
2024-05-13 |
2025-11-20 |
Regeneron Pharmaceuticals, Inc. |
Fgfr3 binding molecules and methods of use thereof
|
|
WO2025240287A1
(en)
|
2024-05-13 |
2025-11-20 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating light chain amyloidosis with bispecific bcma x cd3 antibodies
|
|
WO2025244973A1
(en)
|
2024-05-20 |
2025-11-27 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating multiple myeloma with bispecific bcma x cd3 antibodies
|
|
US20250361309A1
(en)
|
2024-05-24 |
2025-11-27 |
Regeneron Pharmaceuticals, Inc. |
Tumor-targeted split il12 receptor agonists
|
|
WO2025250495A1
(en)
|
2024-05-28 |
2025-12-04 |
Regeneron Pharmaceuticals, Inc. |
Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals
|
|
WO2025255452A2
(en)
|
2024-06-07 |
2025-12-11 |
Regeneron Pharmaceuticals, Inc. |
Antigen-binding molecules that bind to aav particles and uses thereof
|
|
US20250376524A1
(en)
|
2024-06-07 |
2025-12-11 |
Regeneron Pharmaceuticals, Inc. |
Tetravalent multispecific binding molecules and methods of use thereof
|
|
US20260055171A1
(en)
|
2024-06-11 |
2026-02-26 |
Regeneron Pharmaceuticals, Inc. |
Vegf antagonists and methods of use thereof
|
|
US20260000758A1
(en)
|
2024-06-28 |
2026-01-01 |
Regeneron Pharmaceuticals, Inc. |
Bispecific antigen binding molecules that bind gdf8 and activin a and uses thereof
|
|
WO2026011013A1
(en)
|
2024-07-02 |
2026-01-08 |
Epibiologics, Inc. |
Binding agents and uses thereof
|
|
WO2026015612A1
(en)
|
2024-07-10 |
2026-01-15 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating smarcb1-deficient cancers
|
|
WO2026015729A1
(en)
|
2024-07-11 |
2026-01-15 |
Regeneron Pharmaceuticals, Inc. |
Gprc5d x cd28 bispecific antibodies and methods of use thereof
|
|
WO2026025058A1
(en)
|
2024-07-25 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Aav viral particles retargeted to egfr-expressing cancer cells
|
|
WO2026039325A2
(en)
|
2024-08-12 |
2026-02-19 |
Regeneron Pharmaceuticals, Inc. |
Modified mtm1 genes and uses thereof
|
|
WO2026039791A1
(en)
|
2024-08-16 |
2026-02-19 |
Regeneron Pharmaceuticals, Inc. |
Tumor-targeted split il2 receptor agonists
|
|
WO2026044000A1
(en)
|
2024-08-20 |
2026-02-26 |
Ethyreal Bio, Inc. |
Multispecific antibodies and methods of use thereof
|
|
WO2026050255A2
(en)
|
2024-08-27 |
2026-03-05 |
Regeneron Pharmaceuticals, Inc. |
Anti-slc3a2-apis antigen-binding proteins and methods of use thereof
|
|
WO2026050572A2
(en)
|
2024-08-29 |
2026-03-05 |
Marengo Therapeutics, Inc. |
Multifunctional molecules binding to tcr and uses thereof
|
|
WO2026055669A2
(en)
|
2024-09-09 |
2026-03-12 |
Xencor, Inc. |
Anti-tl1a x anti-il23 antibodies
|