JP2017521101A5 - - Google Patents
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- Publication number
- JP2017521101A5 JP2017521101A5 JP2017522459A JP2017522459A JP2017521101A5 JP 2017521101 A5 JP2017521101 A5 JP 2017521101A5 JP 2017522459 A JP2017522459 A JP 2017522459A JP 2017522459 A JP2017522459 A JP 2017522459A JP 2017521101 A5 JP2017521101 A5 JP 2017521101A5
- Authority
- JP
- Japan
- Prior art keywords
- primary
- lymphocytes
- contacting
- lymphocyte
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 36
- 102000007327 Protamines Human genes 0.000 claims description 3
- 108010007568 Protamines Proteins 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 229950008679 protamine sulfate Drugs 0.000 claims description 3
- 230000009466 transformation Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 17
- 230000001177 retroviral effect Effects 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 claims 8
- 102000000588 Interleukin-2 Human genes 0.000 claims 6
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 3
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000005007 innate immune system Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 description 2
- 229960000633 dextran sulfate Drugs 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462023618P | 2014-07-11 | 2014-07-11 | |
| US62/023,618 | 2014-07-11 | ||
| PCT/US2015/039892 WO2016007827A1 (en) | 2014-07-11 | 2015-07-10 | Methods of improving vector transduction efficiency into t lymphocytes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141042A Division JP2020191901A (ja) | 2014-07-11 | 2020-08-24 | Ｔリンパ球へのベクター導入効率の改善方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521101A JP2017521101A (ja) | 2017-08-03 |
| JP2017521101A5 true JP2017521101A5 (enExample) | 2018-08-30 |
| JP6754761B2 JP6754761B2 (ja) | 2020-09-16 |
Family
ID=55064944
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522459A Active JP6754761B2 (ja) | 2014-07-11 | 2015-07-10 | Ｔリンパ球へのベクター導入効率の改善方法 |
| JP2020141042A Pending JP2020191901A (ja) | 2014-07-11 | 2020-08-24 | Ｔリンパ球へのベクター導入効率の改善方法 |
| JP2023000651A Pending JP2023040152A (ja) | 2014-07-11 | 2023-01-05 | Ｔリンパ球へのベクター導入効率の改善方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020141042A Pending JP2020191901A (ja) | 2014-07-11 | 2020-08-24 | Ｔリンパ球へのベクター導入効率の改善方法 |
| JP2023000651A Pending JP2023040152A (ja) | 2014-07-11 | 2023-01-05 | Ｔリンパ球へのベクター導入効率の改善方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10982189B2 (enExample) |
| EP (2) | EP3167058B1 (enExample) |
| JP (3) | JP6754761B2 (enExample) |
| ES (2) | ES2973524T3 (enExample) |
| WO (1) | WO2016007827A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12590955B2 (en) | 2013-03-15 | 2026-03-31 | Zeon Corporation | Methods and systems for processing particles |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| CN113512522A (zh) | 2013-03-15 | 2021-10-19 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| US11493428B2 (en) | 2013-03-15 | 2022-11-08 | Gpb Scientific, Inc. | On-chip microfluidic processing of particles |
| US10982189B2 (en) | 2014-07-11 | 2021-04-20 | Celgene Corporation | Methods of improving vector transduction efficiency into T lymphocytes |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| US10844353B2 (en) | 2017-09-01 | 2020-11-24 | Gpb Scientific, Inc. | Methods for preparing therapeutically active cells using microfluidics |
| DE102018010282A1 (de) | 2018-01-17 | 2019-07-18 | Immatics US, Inc. | Verfahren zur Feststellung der Wirksamkeit von viralen Vektoren |
| DE102018100967B4 (de) | 2018-01-17 | 2019-08-14 | Immatics US, Inc. | Verfahren zur feststellung der wirksamkeit von viralen vektoren |
| CN108715865B (zh) * | 2018-05-28 | 2021-09-21 | 福建师范大学 | 用于提高细胞转染效率的试剂组合物 |
| US20220267726A1 (en) | 2019-07-18 | 2022-08-25 | Gpb Scientific, Inc. | Ordered processing of blood products to produce therapeutically active cells |
| WO2021133897A1 (en) | 2019-12-28 | 2021-07-01 | Gpb Scientific, Inc. | Microfluidic cartridges for processing particles and cells |
| CA3215429A1 (en) * | 2021-04-06 | 2022-10-13 | Unicet Biotech Co. Llc | Methods to improve stability of virus transduction of .gamma..delta. t cells and applications thereof |
| WO2023286088A1 (en) * | 2021-07-16 | 2023-01-19 | Indian Institute Of Science Education And Research Bhopal | Methods and compositions for viral vector transduction |
| WO2025180499A1 (zh) * | 2024-02-28 | 2025-09-04 | 南京因领生物科技有限公司 | 一种提高细胞中病毒包装产量或质量的方法 |
| CN119530302B (zh) * | 2025-01-22 | 2025-06-27 | 青岛华赛伯曼医学细胞生物有限公司 | 提高til细胞的慢病毒转导效率及转导稳定性的方法及试剂盒 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5665577A (en) | 1989-02-06 | 1997-09-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| ATE292689T1 (de) * | 1995-05-04 | 2005-04-15 | Us Navy | Verbesserte verfahren zur transfektion der t- zellen |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| ATE368122T1 (de) | 1999-04-29 | 2007-08-15 | Cell Genesys Inc | Verfahren und mittel für die herstellung von sicheren rekombinanten lentiviralen vektoren mit hohem titer |
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20060210536A1 (en) * | 2003-04-17 | 2006-09-21 | Curt Horvath | Methods and compositions for inhibiting stat signaling pathways |
| DE602004030105D1 (de) * | 2003-05-05 | 2010-12-30 | Virxsys Corp | Erhöhte transduktion mit abc-transportersubstratenhemmern |
| US20080311095A1 (en) | 2007-05-23 | 2008-12-18 | Sangamo Biosciences, Inc. | Methods and compositions for increased transgene expression |
| EP2573185A3 (en) * | 2005-02-16 | 2013-06-05 | Lentigen Corporation | Lentiviral vectors and their use |
| GB0526255D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| KR20180105266A (ko) | 2005-12-29 | 2018-09-27 | 안트로제네시스 코포레이션 | 태반 줄기 세포 집단 |
| EP2203176B1 (en) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| WO2010059828A1 (en) | 2008-11-19 | 2010-05-27 | Anthrogenesis Corporation | Amnion derived adherent cells |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| WO2012072096A1 (en) | 2010-12-03 | 2012-06-07 | Biontech Ag | Method for cellular rna expression |
| EP3868888A1 (en) * | 2012-02-29 | 2021-08-25 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Retroviral transduction using poloxamers |
| AU2013246443B2 (en) * | 2012-04-11 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting B-cell maturation antigen |
| WO2014046617A1 (en) * | 2012-09-19 | 2014-03-27 | Agency For Science, Technology And Research | Compositions and methods for treating cancer |
| US10982189B2 (en) | 2014-07-11 | 2021-04-20 | Celgene Corporation | Methods of improving vector transduction efficiency into T lymphocytes |
-
2015
- 2015-07-10 US US15/325,376 patent/US10982189B2/en active Active
- 2015-07-10 JP JP2017522459A patent/JP6754761B2/ja active Active
- 2015-07-10 EP EP15818898.7A patent/EP3167058B1/en active Active
- 2015-07-10 ES ES20176483T patent/ES2973524T3/es active Active
- 2015-07-10 EP EP20176483.4A patent/EP3750993B1/en active Active
- 2015-07-10 WO PCT/US2015/039892 patent/WO2016007827A1/en not_active Ceased
- 2015-07-10 ES ES15818898T patent/ES2813437T3/es active Active
-
2020
- 2020-08-24 JP JP2020141042A patent/JP2020191901A/ja active Pending
-
2021
- 2021-03-12 US US17/200,745 patent/US11629335B2/en active Active
-
2023
- 2023-01-05 JP JP2023000651A patent/JP2023040152A/ja active Pending
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