HRP20210001T1 - Kombinacije koje sadržavaju pozitivne alosteričke modulatore metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba - Google Patents
Kombinacije koje sadržavaju pozitivne alosteričke modulatore metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba Download PDFInfo
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- HRP20210001T1 HRP20210001T1 HRP20210001TT HRP20210001T HRP20210001T1 HR P20210001 T1 HRP20210001 T1 HR P20210001T1 HR P20210001T T HRP20210001T T HR P20210001TT HR P20210001 T HRP20210001 T HR P20210001T HR P20210001 T1 HRP20210001 T1 HR P20210001T1
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- 230000000848 glutamatergic effect Effects 0.000 title claims 3
- 239000000556 agonist Substances 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 206010015037 epilepsy Diseases 0.000 claims 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 230000002265 prevention Effects 0.000 claims 5
- 208000030336 Bipolar and Related disease Diseases 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 101000584505 Homo sapiens Synaptic vesicle glycoprotein 2A Proteins 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 102100030701 Synaptic vesicle glycoprotein 2A Human genes 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 229940126027 positive allosteric modulator Drugs 0.000 claims 3
- 229960002161 brivaracetam Drugs 0.000 claims 2
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960004002 levetiracetam Drugs 0.000 claims 2
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 claims 1
- 206010061334 Partial seizures Diseases 0.000 claims 1
- 101710084141 Synaptic vesicle glycoprotein 2A Proteins 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000008579 epileptogenesis Effects 0.000 claims 1
- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- ANWPENAPCIFDSZ-BQBZGAKWSA-N seletracetam Chemical compound CC[C@@H](C(N)=O)N1C[C@@H](C=C(F)F)CC1=O ANWPENAPCIFDSZ-BQBZGAKWSA-N 0.000 claims 1
- 229950000852 seletracetam Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cell Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (18)
1. Kombinacija naznačena time što sadrži
(a) ligand sinaptičkog proteina vezikula 2A ("SV2A") odabran iz skupine koja sadrži levetiracetam, brivaracetam i seletracetam; i
(b) pozitivni alosterički modulator ("PAM") metabotropnog glutamatergičnog receptora podtip 2 ("mGluR2") spoj odabran
[image]
ili njihova farmaceutski prihvatljiva sol ili solvat.
2. Kombinacija prema patentnom zahtjevu 1, naznačena time što je pozitivni alosterički modulator metabotropnog glutamatergičnog receptora podtip 2
[image]
ili njegova hidrokloridna sol.
3. Kombinacija prema patentnom zahtjevu 1 ili 2, naznačena time što je ligand SV2A levetiracetam.
4. Kombinacija prema patentnom zahtjevu 1 ili 2, naznačena time što SV2A ligand je brivaracetam.
5. Farmaceutski pripravak naznačen time što sadrži kombinaciju prema bilo kojem od patentnih zahtjeva 1 do 4, i farmaceutski prihvatljiv nosač.
6. Farmaceutski pripravak prema patentnom zahtjevu 5, naznačen time što je formuliran kao kombinirani farmaceutski pripravak.
7. Farmaceutski pripravak prema patentnom zahtjevu 5, naznačen time što je formuliran u zasebnim farmaceutskim pripravcima.
8. Postupak za pripremu farmaceutskog pripravka u skladu sa zahtjevom 5 ili 6, naznačen time što se kombinacija prema bilo kojem od patentnih zahtjeva 1 do 4 blisko miješa s farmaceutski prihvatljivim nosačem.
9. Proizvod, naznačen time što sadrži kombinaciju kako je definirano u bilo kojem od zahtjeva 1 do 4, kao kombinirani pripravak za istodobnu, odvojenu ili uzastopnu upotrebu u liječenju ili sprječavanju epilepsije i srodnih poremećaja; neuropatske boli; migrene ili rezistentne glavobolje; bipolarnih i srodnih poremećaja.
10. Kombinacija definirana u bilo kojem od patentnih zahtjeva 1 do 4, ili farmaceutski pripravak kako je definiran u bilo kojem od patentnih zahtjeva 5 to 7, naznačen time što se upotrebljava kao lijek.
11. Kombinacija prema bilo kojem od patentnih zahtjeva 1 do 4 naznačena time što se koristi u liječenju ili prevenciji epilepsije; neuropatske boli; migrene ili rezistentne glavobolje; i bipolarnih i srodnih poremećaja.
12. Kombinacija za uporabu prema patentnom zahtjevu 11, naznačena time što se koristi u liječenju ili prevenciji epilepsije.
13. Kombinacija za uporabu prema patentnom zahtjevu 12, naznačena time što je epilepsija, epilepsija rezistentna na liječenje.
14. Kombinacija za uporabu prema patentnom zahtjevu 12, naznačena time što je epilepsija, epilepsija sa žarišnim napadima sa ili bez generalizacije.
15. Kombinacija za uporabu prema patentnom zahtjevu 12, naznačena time što je epilepsija, epilepsija s generaliziranim napadima.
16. Kombinacija za uporabu prema patentnom zahtjevu 12, naznačena time što je epilepsija, epilepsija s primarno generaliziranim tonično-kloničnim napadima.
17. Kombinacija prema bilo kojem od patentnih zahtjeva 1 do 4, ili farmaceutski pripravak kako je definiran u bilo kojem od patentnih zahtjeva 5 do 7, naznačena time što je za uporabu u prevenciji epileptogeneze.
18. Farmaceutski proizvod ili komercijalno pakiranje naznačeno time što sadrži kombinaciju prema bilo kojem od zahtjeva 1 do 10 zajedno s uputama, za istodobnu, odvojenu ili uzastopnu upotrebu u liječenju ili sprječavanju epilepsije; neuropatske boli; migrene ili rezistentne glavobolje; i bipolarnih i srodnih poremećaja.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461929795P | 2014-01-21 | 2014-01-21 | |
EP14153880 | 2014-02-04 | ||
EP14153887 | 2014-02-04 | ||
EP14183324 | 2014-09-03 | ||
EP14187429 | 2014-10-02 | ||
US201462091668P | 2014-12-15 | 2014-12-15 | |
EP18182695.9A EP3431106B1 (en) | 2014-01-21 | 2015-01-20 | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210001T1 true HRP20210001T1 (hr) | 2021-04-16 |
Family
ID=65633001
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191646 HRP20191646T1 (hr) | 2014-01-21 | 2019-09-12 | Kombinacije koje sadržavaju pozitivne alosteričke modulatore ili ortosteričke agoniste metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba |
HRP20210001TT HRP20210001T1 (hr) | 2014-01-21 | 2021-01-03 | Kombinacije koje sadržavaju pozitivne alosteričke modulatore metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191646 HRP20191646T1 (hr) | 2014-01-21 | 2019-09-12 | Kombinacije koje sadržavaju pozitivne alosteričke modulatore ili ortosteričke agoniste metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba |
Country Status (16)
Country | Link |
---|---|
US (1) | US11369606B2 (hr) |
JP (2) | JP6684936B2 (hr) |
KR (2) | KR20200036063A (hr) |
CL (3) | CL2016001815A1 (hr) |
DK (1) | DK3096790T3 (hr) |
ES (2) | ES2860298T3 (hr) |
HR (2) | HRP20191646T1 (hr) |
HU (2) | HUE053734T2 (hr) |
IL (4) | IL279202B2 (hr) |
LT (2) | LT3096790T (hr) |
ME (1) | ME03518B (hr) |
MX (2) | MX2019008632A (hr) |
NZ (1) | NZ722385A (hr) |
PH (2) | PH12019500128A1 (hr) |
PT (1) | PT3096790T (hr) |
UA (1) | UA121965C2 (hr) |
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JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
CN107108608B (zh) | 2014-12-11 | 2020-07-21 | 詹森药业有限公司 | 1,2,4-三唑并[4,3-a]吡啶化合物及其作为mGluR2受体的正向别构调节剂的用途 |
JP7070018B2 (ja) | 2018-04-19 | 2022-05-18 | コニカミノルタ株式会社 | 設定制御装置、設定制御方法およびプログラム |
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