DE60022050C5 - Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems - Google Patents

Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems Download PDF

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DE60022050C5
DE60022050C5 DE60022050T DE60022050T DE60022050C5 DE 60022050 C5 DE60022050 C5 DE 60022050C5 DE 60022050 T DE60022050 T DE 60022050T DE 60022050 T DE60022050 T DE 60022050T DE 60022050 C5 DE60022050 C5 DE 60022050C5
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diseases
metabotrope
treatment
nervous system
central nervous
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DE60022050D1 (de
DE60022050T2 (de
Inventor
C. Bradford VAN WAGENEN
T. Scott MOE
L. Daryl SMITH
M. Susan SHEEHAN
Irina Shcherbakova
Richard Travato
Ruth Walton
Robert Barmore
G. Eric DELMAR
M. Thomas STORMANN
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AstraZeneca AB
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NPS Pharmaceuticals Inc
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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Abstract

Verbindung mit der Struktur
Figure 00000001
worin
X1 und X2 unabhängig CH oder N sind,
X3, N oder C-E ist,
A, B, D, und E unabhängig ausgewählt sind aus der Gruppe, bestehend aus H, OMe, und CF3, oder B und D zusammen -O-(CH2)2-O- oder O-(CH2)2-O- sind, mit der Maßgabe, dass mindestens eines aus A, B, D, und E von H verschieden ist,
R ausgewählt ist aus der Gruppe bestehend aus:
C4-C6-alkyl,
Figure 00000002
worin K H oder Me ist,
G1 H, Me oder Phenyl ist,
G2, K, L, und M unabhängig H oder Me sind,
n 0, 1 oder 2 ist
und X4 und X5 unabhängig N oder CH sind,
oder ein pharmazeutisch annehmbares Salz davon, mit der Maßgabe, dass die Verbindung nicht N-(1-Adamantyl)-7-trifluormethylchinolin-3-carboxamid ist.

Description

  • Das europäische Patent EP 1 196 397 mit Wirkung für die Bundesrepublik Deutschland (nationale Patentnummer 600 22 050) wird gemäß § 64 des Patentgesetzes durch Änderungen im Patentanspruch 1 beschränkt.

Claims (1)

  1. Verbindung mit der Struktur
    Figure 00020001
    worin X1 und X2 unabhängig CH oder N sind, X3, N oder C-E ist, A, B, D, und E unabhängig ausgewählt sind aus der Gruppe, bestehend aus H, OMe, und CF3, oder B und D zusammen -O-(CH2)2-O- oder O-(CH2)2-O- sind, mit der Maßgabe, dass mindestens eines aus A, B, D, und E von H verschieden ist, R ausgewählt ist aus der Gruppe bestehend aus: C4-C6-alkyl,
    Figure 00020002
    worin K H oder Me ist, G1 H, Me oder Phenyl ist, G2, K, L, und M unabhängig H oder Me sind, n 0, 1 oder 2 ist und X4 und X5 unabhängig N oder CH sind, oder ein pharmazeutisch annehmbares Salz davon, mit der Maßgabe, dass die Verbindung nicht N-(1-Adamantyl)-7-trifluormethylchinolin-3-carboxamid ist.
DE60022050T 1999-06-02 2000-06-02 Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems Expired - Fee Related DE60022050C5 (de)

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