|
CH389134A
(de)
|
1960-03-15 |
1965-03-15 |
Ciba Geigy |
Verfahren zur Herstellung neuer Anthrachinonküpenfarbstoffe
|
|
NL293572A
(cg-RX-API-DMAC7.html)
|
1962-06-07 |
|
|
|
|
CH499528A
(de)
|
1965-10-22 |
1970-11-30 |
Ciba Geigy Ag |
Verfahren zur Herstellung neuer Pyrimidine
|
|
CH480410A
(de)
|
1967-01-09 |
1969-10-31 |
Geigy Ag J R |
Verfahren zur Herstellung von wasserlöslichen Azopyrimidinfarbstoffen
|
|
CA961052A
(en)
|
1967-01-12 |
1975-01-14 |
Max Schellenbaum |
N-2-ethylhexyl-n'-aryl ureas and preparation containing them
|
|
FR1593586A
(cg-RX-API-DMAC7.html)
|
1967-10-17 |
1970-06-01 |
|
|
|
US3608087A
(en)
|
1968-06-21 |
1971-09-21 |
Merck & Co Inc |
Feed compositions
|
|
US3887329A
(en)
|
1969-05-05 |
1975-06-03 |
Ciba Geigy Ag |
Hexamethyl phosphotriamide-dye compositions
|
|
BE756953A
(fr)
|
1969-10-02 |
1971-04-01 |
Merck & Co Inc |
Potentialisation d'antibiotiques
|
|
US3686238A
(en)
|
1970-01-19 |
1972-08-22 |
Syntex Corp |
Glycerol esterified with 2-naphthyl-acetic acids and fatty acids
|
|
US3852434A
(en)
|
1970-09-11 |
1974-12-03 |
Merck & Co Inc |
Potentiation of ({31 ) cis-1,2-epoxypropyl)phosphonic acid and analogues thereof
|
|
US3690834A
(en)
|
1971-01-11 |
1972-09-12 |
Syva Co |
Ligand determination with spin labeled compounds by receptor displacement
|
|
US3966744A
(en)
|
1971-01-11 |
1976-06-29 |
Syva Company |
Spin labeled compounds
|
|
DE2106585A1
(de)
|
1971-02-11 |
1972-08-24 |
Farbenfabriken Bayer Ag, 5090 Leverkusen |
Aminothiodiazole und Thiodiazol-Azofarbstoffe
|
|
CH560197A5
(en)
|
1971-05-17 |
1975-03-27 |
Ciba Geigy Ag |
2-alkylthio-4,6-bis (subst amino)-5-nitropyrimidines - - herbicides
|
|
CH558137A
(de)
|
1971-05-17 |
1975-01-31 |
Ciba Geigy Ag |
Mittel zur beeinflussung des pflanzenwachstums.
|
|
DE2226703A1
(de)
|
1972-05-25 |
1973-12-13 |
Schering Ag |
Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung
|
|
US3966764A
(en)
|
1972-07-10 |
1976-06-29 |
Syva Company |
Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs
|
|
US3849420A
(en)
|
1972-10-20 |
1974-11-19 |
Dow Chemical Co |
Bis-(alkylthio-and alkylsulfonyl)-pentachloroquinolines
|
|
CH574206A5
(cg-RX-API-DMAC7.html)
|
1972-11-16 |
1976-04-15 |
Ciba Geigy Ag |
|
|
DE2340569C2
(de)
|
1973-08-10 |
1982-12-02 |
Bayer Ag, 5090 Leverkusen |
Azofarbstoffe
|
|
AT340933B
(de)
|
1973-08-20 |
1978-01-10 |
Thomae Gmbh Dr K |
Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
|
|
DE2341925A1
(de)
|
1973-08-20 |
1975-03-06 |
Thomae Gmbh Dr K |
Neue pyrimidinderivate und verfahren zu ihrer herstellung
|
|
US4057559A
(en)
|
1973-10-01 |
1977-11-08 |
American Home Products Corporation |
Carbazole acetic acid derivatives
|
|
CH584739A5
(cg-RX-API-DMAC7.html)
|
1973-12-21 |
1977-02-15 |
Ciba Geigy Ag |
|
|
US4101541A
(en)
|
1973-12-21 |
1978-07-18 |
Ciba-Geigy Corporation |
3-Cyano-1,2,4-thiadiazolyl-5-czo dyestuffs
|
|
FR2258841B1
(cg-RX-API-DMAC7.html)
|
1974-01-29 |
1977-11-04 |
Ugine Kuhlmann |
|
|
AT327605B
(de)
|
1974-05-06 |
1976-02-10 |
Ciba Geigy Ag |
Mittel zur hemmung des pflanzenwachstums
|
|
AU492126B2
(en)
|
1974-05-14 |
1975-11-20 |
Ciba-Geigy Ag |
Nitropyrimidine derivatives
|
|
FR2306697A1
(fr)
|
1975-04-10 |
1976-11-05 |
Sogeras |
Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants
|
|
US4139705A
(en)
|
1977-05-20 |
1979-02-13 |
The Dow Chemical Company |
Pyrazolopyrimidines
|
|
US4189579A
(en)
|
1977-05-20 |
1980-02-19 |
The Dow Chemical Company |
Aminoalkylthiopurines
|
|
DE2731264A1
(de)
|
1977-07-11 |
1979-02-01 |
Boehringer Mannheim Gmbh |
Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen
|
|
JPS6038696B2
(ja)
|
1977-12-09 |
1985-09-02 |
コニカ株式会社 |
ハロゲン化銀カラ−写真感光材料
|
|
US4242507A
(en)
|
1978-02-23 |
1980-12-30 |
Fujisawa Pharmaceutical Co., Ltd. |
Sulfonic acid esters
|
|
DE2831580C2
(de)
|
1978-07-18 |
1980-09-18 |
Boehringer Mannheim Gmbh, 6800 Mannheim |
Verfahren und Reagens zur Bestimmung von Glycerin
|
|
DE2831850A1
(de)
|
1978-07-20 |
1980-02-07 |
Basf Ag |
N-arylsulfonylpyrrole, ihre herstellung und diese enthaltende therapeutische mittel
|
|
DE2906603A1
(de)
|
1979-02-21 |
1980-09-04 |
Boehringer Mannheim Gmbh |
N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
|
|
US4343804A
(en)
|
1979-03-26 |
1982-08-10 |
A. H. Robins Company, Inc. |
4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
|
|
EP0050671B1
(en)
|
1980-04-28 |
1985-03-20 |
Teijin Limited |
Thiazolo(3,2-a)pyrimidine derivatives, process for preparing same, and drug containing same
|
|
EP0053678A1
(de)
|
1980-12-05 |
1982-06-16 |
BASF Aktiengesellschaft |
5-Amino-1-phenyl-4-cyanpyrazole, diese enthaltende herbizide Mittel, Verfahren zu ihrer Herstellung und ihre Anwendung als Herbizide
|
|
DOP1981004033A
(es)
|
1980-12-23 |
1990-12-29 |
Ciba Geigy Ag |
Procedimiento para proteger plantas de cultivo de la accion fitotoxica de herbicidas.
|
|
DE3334455A1
(de)
|
1983-03-04 |
1984-09-06 |
Bayer Ag, 5090 Leverkusen |
Guanidin - derivate
|
|
US4612376A
(en)
|
1983-03-25 |
1986-09-16 |
Fujisawa Pharmaceutical Co., Ltd. |
Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
|
|
ZA848275B
(en)
|
1983-12-28 |
1985-08-28 |
Degussa |
New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
|
|
DE3406329A1
(de)
|
1984-02-22 |
1985-08-22 |
Merck Patent Gmbh, 6100 Darmstadt |
Pyridone
|
|
JPS6157587A
(ja)
|
1984-08-29 |
1986-03-24 |
Shionogi & Co Ltd |
縮合複素環誘導体および抗潰瘍剤
|
|
PH22302A
(en)
|
1985-02-11 |
1988-07-22 |
Fujisawa Pharmaceutical Co |
Piperidine compounds
|
|
ES8801896A1
(es)
|
1985-03-01 |
1988-03-01 |
Duphar Int Res |
Procedimiento para preparar derivados de urea
|
|
DE3601196A1
(de)
|
1986-01-17 |
1987-07-23 |
Merck Patent Gmbh |
1,4-dihydropyridine
|
|
US4810699A
(en)
|
1987-02-20 |
1989-03-07 |
American Home Products Corporation |
Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
|
|
CA1340284C
(en)
|
1987-03-19 |
1998-12-22 |
Zeneca Inc. |
Herbicidal substituted cyclic diones
|
|
EP0324426B1
(en)
|
1988-01-11 |
1996-06-19 |
Fuji Photo Film Co., Ltd. |
Process for forming super high contrast negative images
|
|
US4782076A
(en)
|
1988-03-01 |
1988-11-01 |
American Home Products Corporation |
Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
|
|
PT95692A
(pt)
|
1989-10-27 |
1991-09-13 |
American Home Prod |
Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
|
|
NZ238863A
(en)
|
1990-07-19 |
1993-03-26 |
Janssen Pharmaceutica Nv |
Substituted thiazolyl and pyridinyl derivatives
|
|
US5221678A
(en)
|
1990-07-26 |
1993-06-22 |
Merck Frosst Canada, Inc. |
(quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
|
|
EP0567643A4
(en)
|
1991-01-16 |
1995-07-19 |
Yoshitomi Pharmaceutical |
PYRIDINE COMPOUND USED AS A SELECTIVE DRUG AND NEW PYRIDINE COMPOUND.
|
|
CA2070978A1
(en)
|
1991-06-11 |
1992-12-12 |
William J. Greenlee |
Cyclic renin inhibitors
|
|
GB9114760D0
(en)
|
1991-07-09 |
1991-08-28 |
Pfizer Ltd |
Therapeutic agents
|
|
JPH0533359A
(ja)
|
1991-08-02 |
1993-02-09 |
Kubota Corp |
全旋回型の小型バツクホウ
|
|
EP0556889A1
(en)
|
1992-02-18 |
1993-08-25 |
Duphar International Research B.V |
Method of preparing aryl(homo)piperazines
|
|
DE4208254A1
(de)
|
1992-03-14 |
1993-09-16 |
Hoechst Ag |
Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
|
|
TW237456B
(cg-RX-API-DMAC7.html)
|
1992-04-09 |
1995-01-01 |
Ciba Geigy |
|
|
FR2692575B1
(fr)
|
1992-06-23 |
1995-06-30 |
Sanofi Elf |
Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
|
NZ314207A
(en)
|
1992-09-28 |
2000-12-22 |
Vertex Pharma |
1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
|
|
DE4241632A1
(de)
|
1992-12-10 |
1994-06-16 |
Thomae Gmbh Dr K |
Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
TW370529B
(en)
|
1992-12-17 |
1999-09-21 |
Pfizer |
Pyrazolopyrimidines
|
|
US5998499A
(en)
|
1994-03-25 |
1999-12-07 |
Dentsply G.M.B.H. |
Liquid crystalline (meth)acrylate compounds, composition and method
|
|
JPH0753546A
(ja)
|
1993-08-09 |
1995-02-28 |
Kuraray Co Ltd |
ジアリール置換複素環化合物およびその医薬用途
|
|
AU692484B2
(en)
|
1993-10-12 |
1998-06-11 |
Du Pont Pharmaceuticals Company |
1N-alkyl-N-arylpyrimidinamines and derivatives thereof
|
|
GB9400889D0
(en)
|
1994-01-18 |
1994-03-16 |
Sandoz Ltd |
Novel compounds
|
|
TW530047B
(en)
|
1994-06-08 |
2003-05-01 |
Pfizer |
Corticotropin releasing factor antagonists
|
|
PT781766E
(pt)
|
1994-09-09 |
2004-07-30 |
Nippon Shinyaku Co Ltd |
Derivado heterociclico e medicamento
|
|
RU2137759C1
(ru)
|
1994-11-29 |
1999-09-20 |
Дайниппон Фармасьютикал Ко., Лтд. |
Производное индола
|
|
ES2208737T3
(es)
|
1995-03-10 |
2004-06-16 |
Berlex Laboratories, Inc. |
Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
|
|
US5691364A
(en)
|
1995-03-10 |
1997-11-25 |
Berlex Laboratories, Inc. |
Benzamidine derivatives and their use as anti-coagulants
|
|
IL117659A
(en)
|
1995-04-13 |
2000-12-06 |
Dainippon Pharmaceutical Co |
Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
WO1996033994A1
(en)
|
1995-04-28 |
1996-10-31 |
Nippon Soda Co., Ltd. |
Amino-substituted derivatives, process for the preparation thereof, and herbicide
|
|
JPH10506126A
(ja)
|
1995-05-12 |
1998-06-16 |
ニューロゲン コーポレイション |
新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス
|
|
WO1996036613A1
(en)
|
1995-05-19 |
1996-11-21 |
Nippon Soda Co., Ltd. |
Substituted benzoic acid derivatives, process for the production thereof, and herbicides
|
|
US6403599B1
(en)
|
1995-11-08 |
2002-06-11 |
Pfizer Inc |
Corticotropin releasing factor antagonists
|
|
US6956047B1
(en)
|
1995-06-06 |
2005-10-18 |
Pfizer Inc. |
Corticotropin releasing factor antagonists
|
|
KR0169813B1
(ko)
|
1995-07-12 |
1999-01-15 |
김종인 |
4-아미노-3-아실나프티리딘 유도체
|
|
AU6985796A
(en)
|
1995-08-31 |
1997-03-19 |
Lonza A.G. |
Method of producing dihydroxypyrimidine derivatives
|
|
EP0940387B1
(en)
|
1995-10-26 |
2003-05-07 |
Mitsubishi Pharma Corporation |
Phenylethanolamine compounds useful as beta3 agonist, process for producing the same, and intermediates in the production of the same
|
|
US5849759A
(en)
|
1995-12-08 |
1998-12-15 |
Berlex Laboratories, Inc. |
Naphthyl-substituted benzimidazole derivatives as anti-coagulants
|
|
USH2007H1
(en)
|
1996-01-19 |
2001-12-04 |
Fmc Corporation |
Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
|
|
DE19602095A1
(de)
|
1996-01-22 |
1997-07-24 |
Bayer Ag |
Halogenpyrimidine
|
|
ES2194179T3
(es)
|
1996-02-02 |
2003-11-16 |
Merck & Co Inc |
Derivados heterociclicos como agentes antidiabeticos y antiobesidad.
|
|
KR100421626B1
(ko)
|
1996-02-07 |
2004-05-20 |
뉴로크린 바이오사이언시즈 인코퍼레이티드 |
Crf수용체에대한길항제로서의피라졸로피리미딘
|
|
US5948786A
(en)
|
1996-04-12 |
1999-09-07 |
Sumitomo Pharmaceuticals Company, Limited |
Piperidinylpyrimidine derivatives
|
|
DE19616486C5
(de)
|
1996-04-25 |
2016-06-30 |
Royalty Pharma Collection Trust |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
DE19624659A1
(de)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
Neue Pyridylalken- und Pyridylalkinsäureamide
|
|
WO1997049706A1
(en)
|
1996-06-25 |
1997-12-31 |
Novartis Ag |
SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
|
|
US6060478A
(en)
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
|
US5776967A
(en)
|
1996-07-26 |
1998-07-07 |
American Home Products Corporation |
Pyranoindole inhibitors of COX--2
|
|
AR008789A1
(es)
|
1996-07-31 |
2000-02-23 |
Bayer Corp |
Piridinas y bifenilos substituidos
|
|
US5830911A
(en)
|
1996-08-14 |
1998-11-03 |
American Home Products Corporation |
Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
|
|
TW477787B
(en)
|
1996-08-27 |
2002-03-01 |
Pfizer |
Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
|
|
JP3621706B2
(ja)
|
1996-08-28 |
2005-02-16 |
ファイザー・インク |
置換された６，５―ヘテロ―二環式誘導体
|
|
US6008234A
(en)
|
1996-09-12 |
1999-12-28 |
Berlex Laboratories, Inc. |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
|
|
CN1234798A
(zh)
|
1996-09-12 |
1999-11-10 |
舍林股份公司 |
环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
TW492957B
(en)
|
1996-11-07 |
2002-07-01 |
Novartis Ag |
N-substituted 2-cyanopyrrolidnes
|
|
DZ2376A1
(fr)
|
1996-12-19 |
2002-12-28 |
Smithkline Beecham Plc |
Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
|
|
CA2229123A1
(en)
|
1997-02-11 |
1998-08-11 |
Mitchell Irvin Steinberg |
Pharmaceutical agents
|
|
AU6279598A
(en)
|
1997-02-18 |
1998-09-08 |
Neurocrine Biosciences, Inc. |
Biazacyclic CRF antagonists
|
|
JP2002501492A
(ja)
|
1997-04-22 |
2002-01-15 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
Ｃｒｆアンタゴニストのキノ−及びキナゾリン類
|
|
NZ335823A
(en)
|
1997-04-22 |
2001-06-29 |
Neurocrine Biosciences Inc |
Thiophenopyridines, preparation as CRF receptor antagonists
|
|
JPH11193277A
(ja)
|
1997-05-14 |
1999-07-21 |
Nippon Soda Co Ltd |
ピリミジン誘導体、その製法および有害生物防除剤
|
|
EP1003742A1
(de)
|
1997-08-14 |
2000-05-31 |
Bayer Aktiengesellschaft |
Methoximinomethyloxadiazine als pestizide
|
|
DE19737723A1
(de)
|
1997-08-14 |
1999-02-18 |
Bayer Ag |
Methoximinomethyloxadiazine
|
|
NL1010018C2
(nl)
|
1997-09-09 |
1999-03-10 |
Duphar Int Res |
Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking.
|
|
CN1062110C
(zh)
|
1997-09-19 |
2001-02-21 |
山东工程学院 |
带式钵苗喂入机构
|
|
US6861448B2
(en)
|
1998-01-14 |
2005-03-01 |
Virtual Drug Development, Inc. |
NAD synthetase inhibitors and uses thereof
|
|
US6187777B1
(en)
|
1998-02-06 |
2001-02-13 |
Amgen Inc. |
Compounds and methods which modulate feeding behavior and related diseases
|
|
US6310063B1
(en)
|
1998-04-02 |
2001-10-30 |
Neurogen Corporation |
Aminoalkyl substituted pyrrolo [3,2-E]pyridine and pyrollo [2,3-b]pyrimidine derivatives: modulators of CRF1 receptors
|
|
JP2000038350A
(ja)
|
1998-05-18 |
2000-02-08 |
Yoshitomi Pharmaceut Ind Ltd |
糖尿病治療薬
|
|
EP1105394A1
(en)
|
1998-08-21 |
2001-06-13 |
Du Pont Pharmaceuticals Company |
ISOXAZOLO 4,5-d]PYRIMIDINES AS CRF ANTAGONISTS
|
|
JP3635238B2
(ja)
|
1998-11-10 |
2005-04-06 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
Ｈｉｖの複製を阻害するピリミジン類
|
|
US6262088B1
(en)
|
1998-11-19 |
2001-07-17 |
Berlex Laboratories, Inc. |
Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
|
|
CA2348377C
(en)
|
1998-11-20 |
2008-12-02 |
Arena Pharmaceuticals, Inc. |
Human orphan g protein-coupled receptors
|
|
CO5150173A1
(es)
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
US6239126B1
(en)
|
1998-12-17 |
2001-05-29 |
American Home Products Corporation |
Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
|
|
AU3123500A
(en)
|
1998-12-17 |
2000-07-03 |
American Home Products Corporation |
Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1areceptor activity
|
|
BR9916363A
(pt)
|
1998-12-18 |
2001-12-11 |
Axys Pharm Inc |
Composto, composição farmacêutica e método paratratar ou prevenir um distúrbio tromboembólico
|
|
CZ27399A3
(cs)
|
1999-01-26 |
2000-08-16 |
Ústav Experimentální Botaniky Av Čr |
Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
|
|
US6267985B1
(en)
|
1999-06-30 |
2001-07-31 |
Lipocine Inc. |
Clear oil-containing pharmaceutical compositions
|
|
MXPA01009307A
(es)
|
1999-03-17 |
2002-07-30 |
Astrazeneca Ab |
Derivados de amida.
|
|
EP1040831A3
(en)
|
1999-04-02 |
2003-05-02 |
Pfizer Products Inc. |
Use of corticotropin releasing factor (CRF) antagonists to prevent sudden death
|
|
HRP20010795A2
(en)
|
1999-04-28 |
2003-02-28 |
Aventis Pharma Gmbh |
Di-aryl acid derivatives as ppar receptor ligands
|
|
EP1074549B1
(en)
|
1999-08-06 |
2003-11-19 |
F. Hoffmann-La Roche Ag |
Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors
|
|
JP2003509428A
(ja)
|
1999-09-17 |
2003-03-11 |
アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー |
治療薬としてのピラゾロピリミジン
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
JP2001089452A
(ja)
|
1999-09-22 |
2001-04-03 |
Sankyo Co Ltd |
ピリミジン誘導体
|
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
HRP20020247B1
(hr)
|
1999-09-24 |
2011-02-28 |
Janssen Pharmaceutica N.V. |
Antivirusni pripravci
|
|
CN1377354A
(zh)
|
1999-09-30 |
2002-10-30 |
纽罗杰有限公司 |
某些亚烷基二胺一取代的吡唑并[1,5－a]－1,5－嘧啶和吡唑并[1,5－a]－1,3,5－三嗪
|
|
US6506762B1
(en)
|
1999-09-30 |
2003-01-14 |
Neurogen Corporation |
Certain alkylene diamine-substituted heterocycles
|
|
US6476038B1
(en)
|
1999-09-30 |
2002-11-05 |
Neurogen Corporation |
Amino substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
|
|
DE19947154A1
(de)
|
1999-10-01 |
2001-10-04 |
Bayer Ag |
Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
|
|
US6887870B1
(en)
|
1999-10-12 |
2005-05-03 |
Bristol-Myers Squibb Company |
Heterocyclic sodium/proton exchange inhibitors and method
|
|
IL139197A0
(en)
|
1999-10-29 |
2001-11-25 |
Pfizer Prod Inc |
Use of corticotropin releasing factor antagonists and related compositions
|
|
GR990100388A
(el)
|
1999-11-09 |
2001-07-31 |
|
Φαρμακευτικος συνδυασμος αποτελουμενος απο χωριστες δοσολογικες μορφες σε συσκευασια συμμορφωσης (compliance package) ενος αναστολεα της αναγωγασης του υδροξυ-μεθυλο-γλουταρυλο συνενζυμου α (στατινης, statin) και ενος παραγωγου του φιμπρικου οξεος....
|
|
CA2393359A1
(en)
|
1999-12-22 |
2001-06-28 |
Merck Frosst Canada & Co. |
Aromatic phosphonates as protein tyrosine phosphatase 1b (ptp-1b) inhibitors
|
|
DE19962936A1
(de)
|
1999-12-24 |
2001-06-28 |
Bayer Ag |
Neue beta-Aminosäureverbindungen als Integrinantagonisten
|
|
EP1246815B1
(en)
|
1999-12-30 |
2004-03-17 |
H. Lundbeck A/S |
Phenylpiperazinyl derivatives
|
|
BR0107662A
(pt)
|
2000-01-18 |
2002-11-19 |
Pfizer Prod Inc |
Antagonistas do fator de liberação de corticotropina
|
|
PL355866A1
(en)
|
2000-02-09 |
2004-05-31 |
Hokuriku Seiyaku Co, Ltd. |
1h-imidazopyridine derivatives
|
|
JP2003523418A
(ja)
|
2000-02-15 |
2003-08-05 |
フオスター・ミラー・インコーポレイテツド |
揮発性有機成分を含まない放射硬化性樹脂組成物
|
|
US6569879B2
(en)
|
2000-02-18 |
2003-05-27 |
Merck & Co., Inc. |
Aryloxyacetic acids for diabetes and lipid disorders
|
|
CA2400021A1
(en)
|
2000-02-18 |
2001-08-23 |
Merck & Co., Inc. |
Aryloxyacetic acids for diabetes and lipid disorders
|
|
ES2240449T3
(es)
|
2000-02-25 |
2005-10-16 |
F. Hoffmann-La Roche Ag |
Moduladores receptores de adenosina.
|
|
SK14642002A3
(sk)
|
2000-04-12 |
2003-05-02 |
Novartis Ag |
Kombinované farmaceutické prostriedky obsahujúce antagonistu AT1-receptora a/alebo inhibítor HMG-CoA reduktázy a/alebo ACE inhibítor
|
|
EP1282607B1
(en)
|
2000-05-08 |
2015-11-11 |
Janssen Pharmaceutica NV |
Prodrugs of hiv replication inhibiting pyrimidines
|
|
DE10024319A1
(de)
|
2000-05-17 |
2001-11-22 |
Merck Patent Gmbh |
Bisacylguanidine
|
|
AU6744501A
(en)
|
2000-05-18 |
2001-11-26 |
Bayer Aktiengesellschaft |
Regulation of human dopamine-like g protein-coupled receptor
|
|
EP1287002A1
(en)
|
2000-05-18 |
2003-03-05 |
Neurocrine Biosciences, Inc. |
Crf receptor antagonists
|
|
WO2001090082A1
(en)
|
2000-05-25 |
2001-11-29 |
F. Hoffmann-La Roche Ag |
Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
|
|
US6620821B2
(en)
|
2000-06-15 |
2003-09-16 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
|
KR20030017569A
(ko)
|
2000-06-28 |
2003-03-03 |
테바 파마슈티컬 인더스트리즈 리미티드 |
카르베딜올
|
|
NZ523445A
(en)
|
2000-06-29 |
2004-10-29 |
Abbott Lab |
Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
|
|
AR028782A1
(es)
|
2000-07-05 |
2003-05-21 |
Taisho Pharmaceutical Co Ltd |
Derivados heterociclicos tetrahidropiridino o piperidino
|
|
US6444685B1
(en)
|
2000-07-17 |
2002-09-03 |
Wyeth |
N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
|
|
WO2002006237A1
(en)
|
2000-07-18 |
2002-01-24 |
Yamanouchi Pharmaceutical Co., Ltd. |
Medicine comprising dicyanopyridine derivative
|
|
US6410583B1
(en)
|
2000-07-25 |
2002-06-25 |
Merck Frosst Canada & Co. |
Cyclopentanoindoles, compositions containing such compounds and methods of treatment
|
|
DE60128475T2
(de)
|
2000-07-25 |
2008-02-07 |
Merck & Co., Inc. |
N-substituierte indole mit anwendung in der behandlung von diabetes
|
|
AU2001284417A1
(en)
|
2000-09-05 |
2002-03-22 |
Taisho Pharmaceutical Co. Ltd. |
Hair growth stimulants
|
|
TWI293877B
(en)
|
2000-09-20 |
2008-03-01 |
Rtp Pharma Inc |
Spray drying process and compositions of fenofibrate
|
|
US20030224058A1
(en)
|
2002-05-24 |
2003-12-04 |
Elan Pharma International, Ltd. |
Nanoparticulate fibrate formulations
|
|
US7276249B2
(en)
|
2002-05-24 |
2007-10-02 |
Elan Pharma International, Ltd. |
Nanoparticulate fibrate formulations
|
|
PE20020507A1
(es)
|
2000-10-17 |
2002-06-25 |
Schering Corp |
Compuestos no-imidazoles como antagonistas del receptor histamina h3
|
|
AU2002223626A1
(en)
|
2000-10-20 |
2002-04-29 |
Novartis Ag |
Combinations of a thyromimetic compound and a statin
|
|
PT1333833E
(pt)
|
2000-10-23 |
2011-12-09 |
Glaxosmithkline Llc |
Novo composto 8h-pirido[2,3-d]pirimidin-7-ona trissusbtituída para o tratamento de doenças mediadas por csbp/p38 cinase
|
|
JP4350946B2
(ja)
|
2000-10-31 |
2009-10-28 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体
|
|
MXPA03003714A
(es)
|
2000-11-03 |
2004-05-04 |
Neurocrine Biosciences Inc |
Antagonistas del receptor crf y metodos relacionados con los mismos.
|
|
US20020058026A1
(en)
|
2000-11-13 |
2002-05-16 |
Milton Hammerly |
HMG CoA reductase inhibitor medications combined wih CoEnzyme Q-10
|
|
AU2002223492A1
(en)
|
2000-11-14 |
2002-05-27 |
Neurosearch A/S |
Use of malaria parasite anion channel blockers for treating malaria
|
|
AU2002215218A1
(en)
|
2000-11-17 |
2002-05-27 |
Takeda Chemical Industries Ltd. |
Isoxazole derivatives
|
|
UA77165C2
(en)
|
2000-11-17 |
2006-11-15 |
Lilly Co Eli |
(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
|
|
CA2448729A1
(en)
|
2000-11-20 |
2002-05-23 |
Biovitrum Ab |
Piperazinyl and piperidyl substituted heterocyclic compounds
|
|
EP1338651B9
(en)
|
2000-12-01 |
2007-05-09 |
Astellas Pharma Inc. |
Method of screening remedy for diabetes
|
|
US20020137755A1
(en)
|
2000-12-04 |
2002-09-26 |
Bilodeau Mark T. |
Tyrosine kinase inhibitors
|
|
US20020107262A1
(en)
|
2000-12-08 |
2002-08-08 |
3M Innovative Properties Company |
Substituted imidazopyridines
|
|
US6545016B1
(en)
|
2000-12-08 |
2003-04-08 |
3M Innovative Properties Company |
Amide substituted imidazopyridines
|
|
US6545017B1
(en)
|
2000-12-08 |
2003-04-08 |
3M Innovative Properties Company |
Urea substituted imidazopyridines
|
|
US6525064B1
(en)
|
2000-12-08 |
2003-02-25 |
3M Innovative Properties Company |
Sulfonamido substituted imidazopyridines
|
|
DE60117605T2
(de)
|
2000-12-21 |
2006-12-07 |
Bristol-Myers Squibb Co. |
Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie
|
|
PT1355644E
(pt)
|
2001-01-26 |
2006-11-30 |
Schering Corp |
Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
|
|
AU2002240235B2
(en)
|
2001-01-30 |
2006-07-06 |
Merck & Co., Inc. |
Acyl sulfamides for treatment of obesity, diabetes and lipid disorders
|
|
WO2002064616A2
(en)
|
2001-01-30 |
2002-08-22 |
University Of Virgina Patent Foundation |
Agonists and antagonists of sphingosine-1-phosphate receptors
|
|
US7342021B2
(en)
|
2001-02-08 |
2008-03-11 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
|
JP2004521124A
(ja)
|
2001-02-09 |
2004-07-15 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病および脂質障害用の２−アリールオキシ−２−アリールアルカン酸類
|
|
DE10110754A1
(de)
|
2001-03-07 |
2002-09-19 |
Bayer Ag |
Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
|
|
WO2002072101A1
(en)
|
2001-03-13 |
2002-09-19 |
Bristol-Myers Squibb Pharma Company |
A corticotropin releasing factor receptor ligand, its enantiomer and pharmaceutically acceptable salts
|
|
US7534547B2
(en)
|
2001-03-29 |
2009-05-19 |
Osaka Gas Company Limited |
Optically active compound and photosensitive resin composition
|
|
WO2002081454A1
(en)
|
2001-04-09 |
2002-10-17 |
Dr. Reddy's Laboratories Ltd. |
Derivatives of aryl acids, their use in medicine, process for their preparation and pharmaceutical compositions containing them
|
|
EP1385842A1
(en)
|
2001-04-20 |
2004-02-04 |
Wyeth |
Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
|
|
US7179817B2
(en)
|
2001-05-10 |
2007-02-20 |
Ono Pharmaceutical Co., Ltd. |
Carboxylic acid derivatives and drugs containing the same as the active ingredient
|
|
ES2332505T3
(es)
|
2001-06-01 |
2010-02-08 |
F. Hoffmann-La Roche Ag |
Derivados de pirimidina, triazina y pirazina como receptores de glutamato.
|
|
JP2005500294A
(ja)
|
2001-06-19 |
2005-01-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
ホスホジエステラーゼ７に対するピリミジン阻害剤
|
|
US6825198B2
(en)
|
2001-06-21 |
2004-11-30 |
Pfizer Inc |
5-HT receptor ligands and uses thereof
|
|
EP1406875B1
(en)
|
2001-06-26 |
2013-07-31 |
Bristol-Myers Squibb Company |
N-heterocyclic inhibitors of tnf-alpha expression
|
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
|
GB0117899D0
(en)
|
2001-07-23 |
2001-09-12 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2003026661A1
(fr)
|
2001-09-14 |
2003-04-03 |
Yamanouchi Pharmaceutical Co., Ltd. |
Accelerateur de secretion de l'insuline et nouveau derive de pyrimidine
|
|
DE60223699T2
(de)
|
2001-09-27 |
2008-10-30 |
Kyorin Pharmaceutical Co., Ltd. |
Diarylsulfidderivat, dessen additionssalz und immunsuppressivum
|
|
EP1438048A1
(en)
|
2001-10-18 |
2004-07-21 |
Boehringer Ingelheim Pharmaceuticals Inc. |
1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
|
|
SE0104334D0
(sv)
|
2001-12-19 |
2001-12-19 |
Astrazeneca Ab |
Therapeutic agents
|
|
GB0229931D0
(en)
|
2002-12-21 |
2003-01-29 |
Astrazeneca Ab |
Therapeutic agents
|
|
AU2002351752A1
(en)
|
2001-12-29 |
2003-07-30 |
Novo Nordisk A/S |
Combined use of a glp-1 compound and another drug for treating dyslipidemia
|
|
WO2003057689A1
(en)
|
2002-01-02 |
2003-07-17 |
Fujisawa Pharmaceutical Co., Ltd. |
Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
|
|
US20070225351A1
(en)
|
2002-01-11 |
2007-09-27 |
Lippa Arnold S |
Methods and compositions for controlling body weight and appetite
|
|
CA2472680A1
(en)
|
2002-01-18 |
2003-07-31 |
Merck & Co., Inc. |
Selective s1p1/edg1 receptor agonists
|
|
ATE441654T1
(de)
|
2002-01-18 |
2009-09-15 |
Merck & Co Inc |
Edg-rezeptoragonisten
|
|
AU2003205630A1
(en)
|
2002-01-18 |
2003-07-30 |
The Genetics Company Inc. |
Beta-secretase inhibitors
|
|
GB0201850D0
(en)
|
2002-01-26 |
2002-03-13 |
Astrazeneca Ab |
Therapeutic treatment
|
|
US20050107345A1
(en)
|
2002-03-01 |
2005-05-19 |
Doherty George A. |
Aminoalkylphosphonates and related compounds as edg receptor agonists
|
|
CA2477423A1
(en)
|
2002-03-01 |
2003-09-12 |
Merck & Co., Inc. |
Aminoalkylphosphonates and related compounds as edg receptor agonists
|
|
ATE507210T1
(de)
|
2002-03-07 |
2011-05-15 |
X Ceptor Therapeutics Inc |
Chinazolinon modulatoren von nukleinrezeptoren
|
|
JP2005520821A
(ja)
|
2002-03-15 |
2005-07-14 |
チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド |
４−アミノピリミジン及び表面の抗菌処理のためのその使用
|
|
TW200810743A
(en)
|
2002-03-22 |
2008-03-01 |
Novartis Ag |
Combination of organic compounds
|
|
AU2003225027A1
(en)
|
2002-04-16 |
2003-11-03 |
Merck And Co., Inc. |
Combination therapy using a ppar alpha/gamma agonist
|
|
AU2003222786A1
(en)
|
2002-04-18 |
2003-10-27 |
Ucb, S.A. |
Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
|
|
DE10219435A1
(de)
|
2002-05-02 |
2003-11-13 |
Bayer Cropscience Ag |
Substituierte Pyrazolo-pyrimidin-4-one
|
|
US6747048B2
(en)
|
2002-05-08 |
2004-06-08 |
Bristol-Myers Squibb Company |
Pyridine-based thyroid receptor ligands
|
|
US7057046B2
(en)
|
2002-05-20 |
2006-06-06 |
Bristol-Myers Squibb Company |
Lactam glycogen phosphorylase inhibitors and method of use
|
|
AU2003245313A1
(en)
|
2002-06-10 |
2003-12-22 |
Elan Pharma International, Ltd |
Nanoparticulate formulations comprising hmg coa reductase inhibitor derivatives (statins), novel combinations thereof as well as manufacturing of these pharmaceutical compositions
|
|
JP2005531606A
(ja)
|
2002-06-10 |
2005-10-20 |
エラン ファーマ インターナショナル，リミティド |
ナノ粒子ステロール製剤およびステロールの組合せ
|
|
AU2003241477A1
(en)
|
2002-06-10 |
2003-12-22 |
Elan Pharma International, Ltd. |
Nanoparticulate polycosanol formulations and novel polycosanol combinations
|
|
AR040241A1
(es)
|
2002-06-10 |
2005-03-23 |
Merck & Co Inc |
Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
|
|
US20060122106A1
(en)
|
2002-06-14 |
2006-06-08 |
Amylin Pharmaceuticals, Inc |
Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
|
|
US7199142B2
(en)
|
2002-06-17 |
2007-04-03 |
Merck & Co., Inc. |
1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists
|
|
DE10226943A1
(de)
|
2002-06-17 |
2004-01-08 |
Bayer Ag |
Phenylaminopyrimidine und ihre Verwendung
|
|
GB0214254D0
(en)
|
2002-06-20 |
2002-07-31 |
Glaxo Group Ltd |
Chemical compounds
|
|
SE0201980D0
(sv)
|
2002-06-24 |
2002-06-24 |
Astrazeneca Ab |
Novel compounds
|
|
SE0201976D0
(sv)
|
2002-06-24 |
2002-06-24 |
Astrazeneca Ab |
Novel compounds
|
|
JP5219329B2
(ja)
|
2002-06-28 |
2013-06-26 |
ネステク、リミテッド |
下痢の予防又は治療用の医薬組成物
|
|
US20040053842A1
(en)
|
2002-07-02 |
2004-03-18 |
Pfizer Inc. |
Methods of treatment with CETP inhibitors and antihypertensive agents
|
|
US7071210B2
(en)
|
2002-07-02 |
2006-07-04 |
Pfizer Inc. |
CETP inhibitors in combination with antihypertensive agents and uses thereof
|
|
JPWO2004007472A1
(ja)
|
2002-07-10 |
2005-11-17 |
小野薬品工業株式会社 |
Ｃｃｒ４アンタゴニストおよびその医薬用途
|
|
US20060167020A1
(en)
|
2002-07-23 |
2006-07-27 |
Dickerson Scott H |
Pyrazolopyrimidines as kinase inhibitors
|
|
JP2005536517A
(ja)
|
2002-07-23 |
2005-12-02 |
スミスクライン ビーチャム コーポレーション |
キナーゼインヒビターとしてのピラゾロピリミジン
|
|
EP1534389A2
(en)
|
2002-07-23 |
2005-06-01 |
SmithKline Beecham Corporation |
Pyrazolopyrimidines as kinase inhibitors
|
|
US20060105445A1
(en)
|
2002-07-29 |
2006-05-18 |
Klaus Godl |
Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins
|
|
US7241790B2
(en)
|
2002-07-30 |
2007-07-10 |
University Of Virginia Patent Foundation |
Compounds active in spinigosine 1-phosphate signaling
|
|
EP1539137B1
(en)
|
2002-07-30 |
2010-05-26 |
Merck Sharp & Dohme Corp. |
Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
|
|
JP4475406B2
(ja)
|
2002-07-30 |
2010-06-09 |
メルク・シャープ・エンド・ドーム・コーポレイション |
異常脂血症および他の脂質障害の治療用のＰＰＡＲα選択的化合物
|
|
JP2004067575A
(ja)
|
2002-08-06 |
2004-03-04 |
Yaizu Suisankagaku Industry Co Ltd |
糖尿病治療薬効果促進剤
|
|
NZ537952A
(en)
|
2002-08-08 |
2008-04-30 |
Amgen Inc |
Vanilloid receptor ligands and their use in treatments
|
|
DE10237722A1
(de)
|
2002-08-17 |
2004-08-19 |
Aventis Pharma Deutschland Gmbh |
Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
|
|
CA2495799A1
(en)
|
2002-08-21 |
2004-03-04 |
Merck & Co., Inc. |
Combination therapy using a dual ppar alpha/gamma agonist and an angiotensin ii type i receptor antagonist
|
|
RU2328483C2
(ru)
|
2002-08-29 |
2008-07-10 |
Мерк Энд Ко., Инк. |
Индолы, обладающие противодиабетической активностью
|
|
CA2495915A1
(en)
|
2002-08-29 |
2004-03-11 |
Merck & Co., Inc. |
Indoles having anti-diabetic activity
|
|
JPWO2004024943A1
(ja)
|
2002-09-11 |
2006-01-12 |
アステラス製薬株式会社 |
インスリン含量増加剤スクリーニング方法
|
|
WO2004029204A2
(en)
|
2002-09-27 |
2004-04-08 |
Merck & Co., Inc. |
Substituted pyrimidines
|
|
US7067658B2
(en)
|
2002-09-30 |
2006-06-27 |
Bristol-Myers Squibb Company |
Pyridino and pyrimidino pyrazinones
|
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
|
WO2004033710A2
(en)
|
2002-10-09 |
2004-04-22 |
Genaissance Pharmaceuticals, Inc. |
Itgb3 gene haplotypes and atorvastatin dose effects on hdl cholesterol
|
|
AU2003301302A1
(en)
|
2002-10-15 |
2004-05-04 |
Smithkline Beecham Corporation |
Pyradazine compounds as gsk-3 inhibitors
|
|
US7129239B2
(en)
|
2002-10-28 |
2006-10-31 |
Pfizer Inc. |
Purine compounds and uses thereof
|
|
CA2503715A1
(en)
|
2002-10-30 |
2004-05-21 |
Merck & Co., Inc. |
Kinase inhibitors
|
|
AU2003277576A1
(en)
|
2002-11-08 |
2004-06-07 |
Takeda Pharmaceutical Company Limited |
Receptor function controlling agent
|
|
US7098235B2
(en)
|
2002-11-14 |
2006-08-29 |
Bristol-Myers Squibb Co. |
Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
|
|
US20040110241A1
(en)
|
2002-12-06 |
2004-06-10 |
Segal Mark S. |
Materials and methods for monitoring vascular endothelial function
|
|
CA2510793A1
(en)
|
2002-12-20 |
2004-07-15 |
Bayer Pharmaceuticals Corporation |
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
|
|
JO2397B1
(en)
|
2002-12-20 |
2007-06-17 |
ميرك شارب اند دوم كوربوريشن |
Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
|
|
WO2004058727A1
(en)
|
2002-12-20 |
2004-07-15 |
Bayer Pharmaceuticals Corporation |
Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
|
|
CA2509218C
(en)
|
2002-12-20 |
2010-09-07 |
Merck & Co., Inc. |
1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists
|
|
GB0230021D0
(en)
|
2002-12-23 |
2003-01-29 |
Syngenta Ltd |
Fungicides
|
|
GB0230020D0
(en)
|
2002-12-23 |
2003-01-29 |
Syngenta Ltd |
Fungicides
|
|
CN102558155A
(zh)
|
2003-01-14 |
2012-07-11 |
阿伦纳药品公司 |
作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
|
|
US20070066640A1
(en)
|
2003-01-16 |
2007-03-22 |
Emiliano Castiglioni |
Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists
|
|
JP2007504285A
(ja)
|
2003-01-17 |
2007-03-01 |
メルク エンド カムパニー インコーポレーテッド |
Ｎ−シクロヘキシルアミノカルボニルベンゼンスルホンアミド誘導体
|
|
JP4505449B2
(ja)
|
2003-02-11 |
2010-07-21 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
新規二環式化合物および組成物
|
|
TW200418829A
(en)
|
2003-02-14 |
2004-10-01 |
Avanir Pharmaceutics |
Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
|
|
KR101005171B1
(ko)
|
2003-02-18 |
2011-01-04 |
교린 세이야꾸 가부시키 가이샤 |
아미노포스폰산 유도체와 그 부가염 및 ｓ1ｐ 수용체조절제
|
|
EP1606282B1
(en)
|
2003-02-24 |
2008-11-12 |
Arena Pharmaceuticals, Inc. |
Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism
|
|
JP2004269469A
(ja)
|
2003-03-12 |
2004-09-30 |
Yamanouchi Pharmaceut Co Ltd |
ピリミジン誘導体又はその塩
|
|
JP2004269468A
(ja)
|
2003-03-12 |
2004-09-30 |
Yamanouchi Pharmaceut Co Ltd |
ピリミジン誘導体又はその塩
|
|
EP1622872A1
(en)
|
2003-03-28 |
2006-02-08 |
Pfizer Products Inc. |
1,2,4-substituerte 1,2,3,4-tetrahydro-and 1,2 dihydro-quinoline and 1,2,3,4-tetrahydro-quinoxaline derivatives as cetp inhibitors for the treatment of atherosclerosis and obesity
|
|
EP1628970A2
(en)
|
2003-04-30 |
2006-03-01 |
The Institutes of Pharmaceutical Discovery, LLC |
Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
|
|
AU2004234067B2
(en)
|
2003-04-30 |
2008-02-28 |
Novartis Ag |
Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators
|
|
EP1622860B1
(en)
|
2003-04-30 |
2012-02-29 |
Novartis AG |
AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORs
|
|
TWI393560B
(zh)
|
2003-05-02 |
2013-04-21 |
Japan Tobacco Inc |
包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
|
|
EP1475094B8
(en)
|
2003-05-06 |
2011-01-12 |
Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) |
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
|
|
SE0301368D0
(sv)
|
2003-05-09 |
2003-05-09 |
Astrazeneca Ab |
Chemical compounds
|
|
US7083933B1
(en)
|
2003-05-09 |
2006-08-01 |
Prosidion Limited |
Methods for identification of modulators of OSGPR116 activity
|
|
WO2004103279A2
(en)
|
2003-05-15 |
2004-12-02 |
Merck & Co., Inc. |
3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
|
|
WO2004104205A2
(en)
|
2003-05-16 |
2004-12-02 |
Merck & Co., Inc. |
Enzymatic preparation of chiral indole esters
|
|
AU2004251146A1
(en)
|
2003-05-19 |
2005-01-06 |
Irm, Llc |
Immunosuppressant compounds and compositions
|
|
SI1638551T1
(sl)
|
2003-05-19 |
2012-04-30 |
Irm Llc |
Imunosupresivne spojine in sestavki
|
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
CA2524027C
(en)
|
2003-05-19 |
2013-03-19 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
US6987118B2
(en)
|
2003-05-21 |
2006-01-17 |
Pfizer Inc. |
Tetrahydroisoquinoline derivatives as PPAR-alpha activators
|
|
EP1635773A2
(en)
|
2003-06-06 |
2006-03-22 |
Merck & Co., Inc. (a New Jersey corp.) |
Combination therapy for the treatment of hypertension
|
|
AU2003902882A0
(en)
|
2003-06-10 |
2003-06-26 |
Fujisawa Pharmaceutical Co., Ltd. |
Piperidyl derivatives
|
|
GB0313612D0
(en)
|
2003-06-12 |
2003-07-16 |
Novartis Ag |
Organic compounds
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
WO2005007658A2
(en)
|
2003-07-14 |
2005-01-27 |
Arena Pharmaceuticals, Inc. |
Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
JPWO2005012221A1
(ja)
|
2003-08-04 |
2006-09-14 |
小野薬品工業株式会社 |
ジフェニルエーテル化合物、その製造方法および用途
|
|
SI2287156T1
(sl)
|
2003-08-15 |
2013-09-30 |
Novartis Ag |
2,4-di(fenilamino)-pirimidini, uporabni pri zdravljenju neoplastičnih bolezni, vnetnih motenj in motenj imunskega sistema
|
|
US20050043327A1
(en)
|
2003-08-21 |
2005-02-24 |
Pfizer Inc |
Pharmaceutical composition for the prevention and treatment of addiction in a mammal
|
|
EP1660449B1
(en)
|
2003-08-28 |
2009-11-18 |
Novartis AG |
Aminopropanol derivatives
|
|
CN1874991A
(zh)
|
2003-08-29 |
2006-12-06 |
小野药品工业株式会社 |
能够结合s1p受体的化合物及其药物用途
|
|
AU2004268024B2
(en)
|
2003-09-02 |
2007-07-12 |
Merck Sharp & Dohme Llc |
Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
|
|
WO2005023762A1
(en)
|
2003-09-04 |
2005-03-17 |
Abbott Laboratories |
Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
|
|
TW201127828A
(en)
|
2003-09-05 |
2011-08-16 |
Vertex Pharma |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
US7732442B2
(en)
|
2003-09-05 |
2010-06-08 |
Ono Pharmaceutical Co., Ltd. |
Chemokine receptor antagonist and medical use thereof
|
|
WO2005026148A1
(en)
|
2003-09-08 |
2005-03-24 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
JP2007513058A
(ja)
|
2003-09-08 |
2007-05-24 |
武田薬品工業株式会社 |
ジペプチジルぺプチダーゼ阻害剤
|
|
PE20050948A1
(es)
|
2003-09-09 |
2005-12-16 |
Japan Tobacco Inc |
Compuestos de carbamoil-amina como inhibidores de la dipeptidil peptidasa iv
|
|
AU2004275719B2
(en)
|
2003-09-23 |
2010-08-19 |
Merck Sharp & Dohme Corp. |
Quinoline potassium channel inhibitors
|
|
US20070021430A1
(en)
|
2003-09-23 |
2007-01-25 |
Chen Alex M |
Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
|
|
JP2007528872A
(ja)
|
2003-10-01 |
2007-10-18 |
メルク エンド カムパニー インコーポレーテッド |
Ｓ１ｐ受容体アゴニストとしての３，５−アリール置換、ヘテロアリール置換またはシクロアルキル置換された１，２，４−オキサジアゾール化合物
|
|
WO2005033099A2
(en)
|
2003-10-03 |
2005-04-14 |
Glenmark Pharmaceuticals Ltd. |
Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
|
|
US20060089335A1
(en)
|
2003-10-14 |
2006-04-27 |
Guosong Liu |
Compositions and methods for enhancing cognitive function and synaptic plasticity
|
|
GB0324236D0
(en)
|
2003-10-16 |
2003-11-19 |
Astrazeneca Ab |
Chemical compounds
|
|
PE20050444A1
(es)
|
2003-10-31 |
2005-08-09 |
Takeda Pharmaceutical |
Compuestos de piridina como inhibidores de la peptidasa
|
|
US7638637B2
(en)
|
2003-11-03 |
2009-12-29 |
University Of Virginia Patent Foundation |
Orally available sphingosine 1-phosphate receptor agonists and antagonists
|
|
JPWO2005044780A1
(ja)
|
2003-11-10 |
2007-05-17 |
杏林製薬株式会社 |
アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤
|
|
TW200528106A
(en)
|
2003-11-10 |
2005-09-01 |
Synta Pharmaceuticals Corp |
Pyridine compounds
|
|
NZ547752A
(en)
|
2003-11-12 |
2009-12-24 |
Phenomix Corp |
Heterocyclic boronic acid compounds for inhibiting dipeptidyl peptidase-IV
|
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
|
WO2005058315A1
(en)
|
2003-12-12 |
2005-06-30 |
Ribapharm, Inc. |
Novel heterocyclic compounds as ikk2 inhibitors with anti-hbv activity
|
|
WO2005058849A1
(en)
|
2003-12-15 |
2005-06-30 |
Glenmark Pharmaceuticals Ltd. |
New dipeptidyl peptidase in inhibitors; process for their preparation and compositions containing them
|
|
CA2547198A1
(en)
|
2003-12-17 |
2005-06-30 |
Merck & Co., Inc. |
(3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
|
|
US7875745B2
(en)
|
2003-12-19 |
2011-01-25 |
Ono Pharmaceutical Co., Ltd. |
Compounds having lysophosphatidic acid receptor antagonism and uses thereof
|
|
GB0329498D0
(en)
|
2003-12-19 |
2004-01-28 |
Novartis Ag |
Organic compounds
|
|
DE10360835A1
(de)
|
2003-12-23 |
2005-07-21 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1711491A1
(en)
|
2003-12-24 |
2006-10-18 |
Prosidion Limited |
Heterocyclic derivatives as gpcr receptor agonists
|
|
WO2005072530A1
(en)
|
2004-01-16 |
2005-08-11 |
Merck & Co., Inc. |
Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
|
|
GB0401332D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
WO2005075426A1
(en)
|
2004-02-03 |
2005-08-18 |
Glenmark Pharmaceuticals Ltd. |
Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
|
|
EP1745034A1
(en)
|
2004-02-11 |
2007-01-24 |
Amgen Inc. |
Vanilloid receptor ligands and their use in treatments
|
|
TW200530236A
(en)
|
2004-02-23 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Heteroaryl phenylurea
|
|
TW200538433A
(en)
|
2004-02-24 |
2005-12-01 |
Irm Llc |
Immunosuppressant compounds and compositiions
|
|
TWI355934B
(en)
|
2004-02-24 |
2012-01-11 |
Sankyo Co |
Pharmaceutical composition for treatment or prophy
|
|
EP1718604A4
(en)
|
2004-02-24 |
2008-02-13 |
Irm Llc |
COMPOUNDS AND COMPOSITIONS OF IMMUNOSUPPRESSANTS
|
|
CA2558278A1
(en)
|
2004-03-05 |
2005-09-15 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl-substituted five-membered heterocycle derivative
|
|
GB0405289D0
(en)
|
2004-03-09 |
2004-04-21 |
Novartis Ag |
Organic compounds
|
|
GB0405933D0
(en)
|
2004-03-16 |
2004-04-21 |
Glaxo Group Ltd |
Compounds
|
|
CN1942440B
(zh)
|
2004-04-02 |
2011-09-14 |
默沙东公司 |
用于制备环烷基并吲哚衍生物的不对称氢化方法
|
|
CN1968954A
(zh)
|
2004-04-12 |
2007-05-23 |
三共株式会社 |
噻吩并吡啶衍生物
|
|
JP5213229B2
(ja)
|
2004-04-23 |
2013-06-19 |
エグゼリクシス， インコーポレイテッド |
キナーゼ調節因子および使用方法
|
|
DK1756084T3
(da)
|
2004-06-04 |
2009-03-23 |
Arena Pharm Inc |
Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed
|
|
WO2005123677A1
(en)
|
2004-06-16 |
2005-12-29 |
Actelion Pharmaceuticals Ltd |
4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
|
|
JP5315611B2
(ja)
|
2004-06-23 |
2013-10-16 |
小野薬品工業株式会社 |
Ｓ１ｐ受容体結合能を有する化合物およびその用途
|
|
CN101014329B
(zh)
|
2004-07-16 |
2010-09-08 |
杏林制药株式会社 |
用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物
|
|
JP2007284350A
(ja)
|
2004-07-27 |
2007-11-01 |
Takeda Chem Ind Ltd |
糖尿病治療剤
|
|
TW200611687A
(en)
|
2004-07-29 |
2006-04-16 |
Sankyo Co |
Pharmaceutical compositions used for immunosuppressant
|
|
WO2006010379A1
(en)
|
2004-07-29 |
2006-02-02 |
Actelion Pharmaceuticals Ltd. |
Novel thiophene derivatives as immunosuppressive agents
|
|
WO2006013948A1
(ja)
|
2004-08-04 |
2006-02-09 |
Taisho Pharmaceutical Co., Ltd. |
トリアゾール誘導体
|
|
US7241812B2
(en)
|
2004-08-13 |
2007-07-10 |
Praecis Pharmaceuticals, Inc. |
Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
|
|
US20060223866A1
(en)
|
2004-08-13 |
2006-10-05 |
Praecis Pharmaceuticals, Inc. |
Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
|
|
EP1827438B2
(en)
|
2004-09-20 |
2014-12-10 |
Xenon Pharmaceuticals Inc. |
Piperazin derivatives for inhibiting human stearoyl-coa-desaturase
|
|
CN101035528A
(zh)
|
2004-09-23 |
2007-09-12 |
惠氏公司 |
治疗丙型肝炎病毒感染的咔唑和环戊二烯并吲哚衍生物
|
|
AU2005292134B2
(en)
|
2004-10-01 |
2010-12-23 |
Merck Sharp & Dohme Corp. |
Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
JP4862654B2
(ja)
|
2004-10-08 |
2012-01-25 |
アステラス製薬株式会社 |
芳香環縮合ピリミジン誘導体
|
|
AU2005295080A1
(en)
|
2004-10-12 |
2006-04-20 |
Transition Therapeutics Inc. |
Compounds and methods of treating insulin resistance and cardiomyopathy
|
|
TW200621257A
(en)
|
2004-10-20 |
2006-07-01 |
Astellas Pharma Inc |
Pyrimidine derivative fused with nonaromatic ring
|
|
CA2583681A1
(en)
|
2004-10-22 |
2006-05-04 |
Merck & Co., Inc. |
2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
|
|
PT1650186E
(pt)
|
2004-10-22 |
2008-09-16 |
Bioprojet Soc Civ |
Novos derivados de ácidos dicarboxílicos
|
|
AR051596A1
(es)
|
2004-10-26 |
2007-01-24 |
Irm Llc |
Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios
|
|
SG170642A1
(en)
|
2004-11-03 |
2011-05-30 |
Arena Pharm Inc |
Gpr41 and modulators thereof for the treatment of insulin-related disorders
|
|
GB0425035D0
(en)
|
2004-11-12 |
2004-12-15 |
Novartis Ag |
Organic compounds
|
|
AU2005307718A1
(en)
|
2004-11-18 |
2006-05-26 |
The Institutes For Pharmaceutical Discovery, Llc |
Heterocycle substituted carboxylic acids for the treatment of diabetes
|
|
WO2006057448A1
(ja)
|
2004-11-26 |
2006-06-01 |
Takeda Pharmaceutical Company Limited |
アリールアルカン酸誘導体
|
|
WO2006063033A2
(en)
|
2004-12-06 |
2006-06-15 |
University Of Virginia Patent Foundation |
Aryl amide sphingosine 1-phosphate analogs
|
|
EP2371811B1
(en)
|
2004-12-13 |
2014-10-08 |
Ono Pharmaceutical Co., Ltd. |
Azetidinecarboxylic acid derivative and medicinal use thereof
|
|
WO2006064744A1
(ja)
|
2004-12-13 |
2006-06-22 |
Daiichi Sankyo Company, Limited |
糖尿病の治療のための医薬組成物
|
|
CA2591922A1
(en)
|
2004-12-24 |
2006-06-29 |
Prosidion Limited |
G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
|
|
JP5065908B2
(ja)
|
2004-12-24 |
2012-11-07 |
プロシディオン・リミテッド |
Ｇタンパク質結合受容体作動薬
|
|
GB0428514D0
(en)
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
DOP2006000010A
(es)
|
2005-01-10 |
2006-07-31 |
Arena Pharm Inc |
Procedimiento para preparar eteres aromáticos
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
DOP2006000009A
(es)
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
|
AU2006206246A1
(en)
|
2005-01-19 |
2006-07-27 |
Neurogen Corporation |
Heteroaryl substituted piperazinyl-pyridine analogues
|
|
US7914859B2
(en)
|
2005-01-25 |
2011-03-29 |
Merck Patent Gmbh |
Mesogenic compounds, liquid crystal medium and liquid crystal display
|
|
JP2008530135A
(ja)
|
2005-02-14 |
2008-08-07 |
ユニバーシティ オブ バージニア パテント ファンデーション |
アミノ基およびフェニル基で置換されたシクロアルカンならびに５員の複素環を含むスフィンゴシン＝１−リン酸アゴニスト
|
|
EP1863787B1
(en)
|
2005-03-23 |
2011-05-25 |
Actelion Pharmaceuticals Ltd. |
Hydogrenated benzo[c]thiophene derivatives as immunomodulators
|
|
ES2370791T3
(es)
|
2005-03-23 |
2011-12-22 |
Actelion Pharmaceuticals Ltd. |
Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1.
|
|
RU2404178C2
(ru)
|
2005-03-23 |
2010-11-20 |
Актелион Фармасьютиклз Лтд |
Новые производные тиофена в качестве агонистов рецептора сфингозин-1-фосфата-1
|
|
EP1893591A1
(en)
|
2005-06-08 |
2008-03-05 |
Novartis AG |
POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
|
|
WO2006132406A1
(ja)
|
2005-06-09 |
2006-12-14 |
Banyu Pharmaceutical Co., Ltd. |
下痢を伴う疾患の治療剤としてのnpy y2アゴニスト
|
|
CN101203503B
(zh)
|
2005-06-24 |
2011-12-28 |
埃科特莱茵药品有限公司 |
新颖噻吩衍生物
|
|
TWI418350B
(zh)
|
2005-06-24 |
2013-12-11 |
Sankyo Co |
含有ｐｐａｒ調節劑之醫藥組成物的用途
|
|
AU2006264651A1
(en)
|
2005-06-30 |
2007-01-11 |
Prosidion Limited |
G-protein coupled receptor agonists
|
|
EP1899329B1
(en)
|
2005-07-01 |
2011-10-05 |
Irm Llc |
Pyrimidine-substituted benzimidazole derivatives as protein kinase inhibitors
|
|
US20070060573A1
(en)
|
2005-08-10 |
2007-03-15 |
Lars Wortmann |
Acyltryptophanols
|
|
JP2009506046A
(ja)
|
2005-08-23 |
2009-02-12 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
免疫抑制剤化合物および組成物
|
|
NZ565898A
(en)
|
2005-09-16 |
2010-07-30 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200745055A
(en)
|
2005-09-23 |
2007-12-16 |
Organon Nv |
4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
|
|
JPWO2007037196A1
(ja)
|
2005-09-29 |
2009-04-09 |
山本化成株式会社 |
インドリン系化合物及びその製造方法
|
|
AR057894A1
(es)
|
2005-11-23 |
2007-12-26 |
Actelion Pharmaceuticals Ltd |
Derivados de tiofeno
|
|
JP2009520688A
(ja)
|
2005-11-23 |
2009-05-28 |
エピックス デラウェア， インコーポレイテッド |
Ｓ１ｐ受容体調節化合物およびそれらの使用
|
|
EP1984344B1
(en)
|
2005-12-29 |
2012-09-26 |
Lexicon Pharmaceuticals, Inc. |
Multicyclic amino acid derivatives and methods of their use
|
|
TWI404706B
(zh)
|
2006-01-11 |
2013-08-11 |
Actelion Pharmaceuticals Ltd |
新穎噻吩衍生物
|
|
TW200736234A
(en)
|
2006-01-17 |
2007-10-01 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2007083182A2
(en)
|
2006-01-19 |
2007-07-26 |
Orchid Research Laboratories Limited |
Novel heterocycles
|
|
BRPI0706725A2
(pt)
|
2006-01-24 |
2011-04-05 |
Actelion Pharmaceuticals Ltda |
Composto de sais do mesmo , composição farmacêutica , e , uso de um composto
|
|
GB0601744D0
(en)
|
2006-01-27 |
2006-03-08 |
Novartis Ag |
Organic compounds
|
|
TWI389683B
(zh)
|
2006-02-06 |
2013-03-21 |
Kyorin Seiyaku Kk |
A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
|
|
JP2009526073A
(ja)
|
2006-02-09 |
2009-07-16 |
ユニバーシティ オブ バージニア パテント ファンデーション |
二環式スフィンゴシン−１−リン酸受容体アナログ
|
|
TW200806611A
(en)
|
2006-02-09 |
2008-02-01 |
Daiichi Seiyaku Co |
Novel amidopropionic acid derivatives and medicine containing the same
|
|
US20070191371A1
(en)
|
2006-02-14 |
2007-08-16 |
Kalypsys, Inc. |
Heterocyclic modulators of ppar
|
|
EP1984334B1
(en)
|
2006-02-15 |
2014-04-09 |
Allergan, Inc. |
Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
|
|
CN101460458A
(zh)
|
2006-02-15 |
2009-06-17 |
阿勒根公司 |
具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
|
|
WO2007098474A1
(en)
|
2006-02-21 |
2007-08-30 |
University Of Virginia Patent Foundation |
Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as s1p receptor agonists
|
|
US7649098B2
(en)
|
2006-02-24 |
2010-01-19 |
Lexicon Pharmaceuticals, Inc. |
Imidazole-based compounds, compositions comprising them and methods of their use
|
|
JP2009530281A
(ja)
|
2006-03-14 |
2009-08-27 |
アムジエン・インコーポレーテツド |
代謝障害の治療に有用である二環式カルボン酸誘導体
|
|
AR060050A1
(es)
|
2006-03-21 |
2008-05-21 |
Epix Delaware Inc |
Compuestos moduladores del receptor de s1p y uso de los mismos
|
|
JP2007262009A
(ja)
|
2006-03-29 |
2007-10-11 |
Dai Ichi Seiyaku Co Ltd |
ヘテロアリール低級カルボン酸誘導体
|
|
PT2003132E
(pt)
|
2006-04-03 |
2014-05-26 |
Astellas Pharma Inc |
Derivados de oxadiazole como agonistas dos s1p1
|
|
CN103323606A
(zh)
|
2006-04-11 |
2013-09-25 |
艾尼纳制药公司 |
使用gpr119受体鉴定可用于增加个体骨质量的化合物的方法
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
GB0607389D0
(en)
|
2006-04-12 |
2006-05-24 |
Novartis Ag |
Organic compounds
|
|
BRPI0711358A2
(pt)
|
2006-05-09 |
2011-09-27 |
Pfizer Prod Inc |
derivados do ácido cicloalquilamino e suas composições farmacêuticas
|
|
WO2007129473A1
(ja)
|
2006-05-09 |
2007-11-15 |
Daiichi Sankyo Company, Limited |
二環性アリール誘導体
|
|
JPWO2007129745A1
(ja)
|
2006-05-09 |
2009-09-17 |
第一三共株式会社 |
ヘテロアリールアミド低級カルボン酸誘導体
|
|
TW200811140A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200811147A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
EP2043744A2
(en)
|
2006-07-13 |
2009-04-08 |
SmithKline Beecham Corporation |
Chemical compounds
|
|
EP2046766A1
(en)
|
2006-08-01 |
2009-04-15 |
Praecis Pharmaceuticals Incorporated |
Agonists of the sphingosine- 1- phosphate receptor (slp)
|
|
TW200823182A
(en)
|
2006-08-01 |
2008-06-01 |
Praecis Pharm Inc |
Chemical compounds
|
|
EP2099768A2
(en)
|
2006-08-04 |
2009-09-16 |
Praecis Pharmaceuticals Incorporated |
Agonists of the sphingosine-1-phosphate receptor
|
|
MY152176A
(en)
|
2006-08-08 |
2014-08-15 |
Kyorin Seiyaku Kk |
Amino phosphate derivative and s1p receptor modulator having same as an active ingredient
|
|
WO2008024196A1
(en)
|
2006-08-24 |
2008-02-28 |
Praecis Pharmaceuticals Incorporated |
Chemical compounds
|
|
JP2009269819A
(ja)
|
2006-08-25 |
2009-11-19 |
Asahi Kasei Pharma Kk |
アミン化合物
|
|
AU2007291254A1
(en)
|
2006-08-30 |
2008-03-06 |
Inovacia Ab |
Pyrimidine compounds for treating GPR119 related disorders
|
|
BRPI0716815A2
(pt)
|
2006-09-07 |
2013-11-05 |
Allergan Inc |
Co posto heteroatomáticos tendo atividade biológia agonista e/ou antagonista de receptor de esfinfosina-1-fosfato (s1p)
|
|
SI2069336T1
(sl)
|
2006-09-07 |
2013-03-29 |
Actelion Pharmaceuticals Ltd. |
Derivati piridin-4-ila kot imunomodulirna sredstva
|
|
TWI408139B
(zh)
|
2006-09-07 |
2013-09-11 |
Actelion Pharmaceuticals Ltd |
新穎噻吩衍生物
|
|
CN101511783A
(zh)
|
2006-09-08 |
2009-08-19 |
诺瓦提斯公司 |
用于治疗淋巴细胞相互作用介导的疾病的n-联芳(杂)芳基磺酰胺衍生物
|
|
KR20090051774A
(ko)
|
2006-09-21 |
2009-05-22 |
액테리온 파마슈티칼 리미티드 |
페닐 유도체 및 면역조절제로서 이들의 용도
|
|
JP5330260B2
(ja)
|
2006-12-06 |
2013-10-30 |
スミスクライン ビーチャム コーポレーション |
二環式化合物ならびに抗糖尿病薬としての使用
|
|
JP2010513272A
(ja)
|
2006-12-14 |
2010-04-30 |
メルク エンド カムパニー インコーポレーテッド |
アシルビピペリジニル化合物、そのような化合物を含む組成物、及び治療方法
|
|
KR20090095648A
(ko)
|
2006-12-15 |
2009-09-09 |
아보트 러보러터리즈 |
신규한 옥사디아졸 화합물
|
|
JO2701B1
(en)
|
2006-12-21 |
2013-03-03 |
جلاكسو جروب ليميتد |
Vehicles
|
|
AR064650A1
(es)
|
2006-12-21 |
2009-04-15 |
Abbott Lab |
Compuestos agonistas y antagonistas del receptor de esfingosina-1-fosfato
|
|
GB0625648D0
(en)
|
2006-12-21 |
2007-01-31 |
Glaxo Group Ltd |
Compounds
|
|
EP2125723A1
(en)
|
2007-01-11 |
2009-12-02 |
Allergan, Inc. |
6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
|
|
WO2008091967A1
(en)
|
2007-01-26 |
2008-07-31 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2008097819A2
(en)
|
2007-02-05 |
2008-08-14 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
AU2008227979B2
(en)
|
2007-03-16 |
2014-02-06 |
Actelion Pharmaceuticals Ltd |
Amino- pyridine derivatives as S1P1 /EDG1 receptor agonists
|
|
CA2679980A1
(en)
|
2007-03-21 |
2007-09-27 |
Epix Pharmaceuticals, Inc. |
S1p receptor modulating compounds and use thereof
|
|
WO2008128832A1
(en)
|
2007-04-18 |
2008-10-30 |
Nicox S.A. |
Nitroderivatives of non-peptidic renin inhibitors for the treatment of cardiovascular, renal and chronic liver disease, inflammations and metabolic syndrome
|
|
DE602008005285D1
(de)
|
2007-04-19 |
2011-04-14 |
Glaxo Group Ltd |
Oxadiazolsubstituierte indazolderivate zur verwendung als sphingosin-1-phosphat (s1p) -agonisten
|
|
JP2010526145A
(ja)
|
2007-05-04 |
2010-07-29 |
ブリストル−マイヤーズ スクイブ カンパニー |
［６，６］および［６，７］−二環式ｇｐｒ１１９ｇタンパク質結合受容体アゴニスト
|
|
EP2014653A1
(en)
|
2007-06-15 |
2009-01-14 |
Bioprojet |
Novel dicarboxylic acid derivatives as S1P1 receptor agonists
|
|
US20090069288A1
(en)
|
2007-07-16 |
2009-03-12 |
Breinlinger Eric C |
Novel therapeutic compounds
|
|
WO2009019506A1
(en)
|
2007-08-03 |
2009-02-12 |
Astrazeneca Ab |
Heterocyclyc sulfonamides having edg-1 antagonistic activity
|
|
EP2183224B1
(en)
|
2007-08-08 |
2013-11-06 |
Merck Serono S.A. |
6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis
|
|
CA2697551C
(en)
|
2007-09-20 |
2013-03-12 |
Irm Llc |
Piperidine derivatives as modulators of gpr119 activity
|
|
TW200930368A
(en)
|
2007-11-15 |
2009-07-16 |
Astrazeneca Ab |
Bis-(sulfonylamino) derivatives in therapy
|
|
WO2009078983A1
(en)
|
2007-12-18 |
2009-06-25 |
Arena Pharmaceuticals, Inc. |
Tetrahydrocyclopenta[b]indol-3-yl carboxylic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
|
|
CA2711887A1
(en)
|
2008-01-25 |
2009-07-30 |
Arena Pharmaceuticals, Inc. |
Dihydro-1h-pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as s1p1 agonists
|
|
AR070398A1
(es)
|
2008-02-22 |
2010-03-31 |
Gruenenthal Chemie |
Derivados sustituidos de indol
|
|
AU2009227629B2
(en)
*
|
2008-03-17 |
2014-09-04 |
Laboratoires Juvise Pharmaceuticals |
Dosing regimen for a selective S1P1 receptor agonist
|
|
WO2009125434A2
(en)
|
2008-04-07 |
2009-10-15 |
Cadila Healthcare Limited |
Oxime derivatives
|
|
AU2009233984B2
(en)
|
2008-04-07 |
2012-11-22 |
Irm Llc |
Compounds and compositions as modulators of GPR119 activity
|
|
EP2146210A1
(en)
|
2008-04-07 |
2010-01-20 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
|
|
MY156381A
(en)
|
2008-05-14 |
2016-02-15 |
Scripps Research Inst |
Novel modulators of sphingosine phosphate receptors
|
|
WO2009151621A1
(en)
|
2008-06-13 |
2009-12-17 |
Arena Pharmaceuticals, Inc. |
Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
|
|
WO2009151626A1
(en)
|
2008-06-13 |
2009-12-17 |
Arena Pharmaceuticals, Inc. |
Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists
|
|
WO2010011316A1
(en)
|
2008-07-23 |
2010-01-28 |
Arena Pharmaceuticals, Inc. |
SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
|
|
KR101800595B1
(ko)
*
|
2008-08-27 |
2017-11-22 |
아레나 파마슈티칼스, 인크. |
자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체
|
|
HUE026869T2
(en)
|
2008-12-22 |
2016-08-29 |
Novartis Ag |
Dosage regimen for fingolimod for the treatment of multiple sclerosis
|
|
NZ593427A
(en)
*
|
2008-12-22 |
2013-11-29 |
Novartis Ag |
Dosage regimen of an s1p receptor agonist
|
|
AU2009330208A1
(en)
|
2008-12-23 |
2011-08-04 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2010075273A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2010074271A1
(ja)
|
2008-12-26 |
2010-07-01 |
武田薬品工業株式会社 |
糖尿病治療剤
|
|
US20120016119A1
(en)
|
2009-01-22 |
2012-01-19 |
Yasunori Tsuboi |
NOVEL PYRROLO(2,3-d)PYRIMIDINE COMPOUND
|
|
CN102387704A
(zh)
|
2009-02-10 |
2012-03-21 |
雅培制药有限公司 |
S1p5受体的激动剂和拮抗剂，和其用法
|
|
WO2011005290A1
(en)
|
2009-06-23 |
2011-01-13 |
Arena Pharmaceuticals, Inc. |
Disubstituted oxadiazole derivatives useful in the treatment of autoimmune and inflammatory disorders
|
|
WO2011005295A1
(en)
|
2009-06-24 |
2011-01-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
|
|
AR077642A1
(es)
|
2009-07-09 |
2011-09-14 |
Arena Pharm Inc |
Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
|
|
AR077638A1
(es)
|
2009-07-15 |
2011-09-14 |
Lilly Co Eli |
Compuesto de (metanosulfonil -piperidin )-( alcoxi-aril) -tetrahidro- piridina , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de diabetes u obesidad
|
|
WO2011030139A1
(en)
|
2009-09-11 |
2011-03-17 |
Astrazeneca Ab |
4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
|
|
ES2759949T3
(es)
|
2009-10-29 |
2020-05-12 |
Bristol Myers Squibb Co |
Compuestos heterocíclicos tricíclicos
|
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
|
WO2011094008A1
(en)
*
|
2010-01-27 |
2011-08-04 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
|
|
CA2789480A1
(en)
|
2010-03-03 |
2011-09-09 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
|
|
US20130023494A1
(en)
|
2010-04-06 |
2013-01-24 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
JP2013533286A
(ja)
|
2010-07-30 |
2013-08-22 |
セントルイス ユニバーシティ |
疼痛を治療する方法
|
|
BR112013008100A2
(pt)
|
2010-09-22 |
2016-08-09 |
Arena Pharm Inc |
"moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
|
|
EP2672823B1
(en)
|
2011-02-07 |
2016-08-24 |
Biogen MA Inc. |
S1p modulating agents
|
|
US20140018371A1
(en)
|
2011-04-01 |
2014-01-16 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
WO2012145361A1
(en)
|
2011-04-19 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20140038889A1
(en)
|
2011-04-22 |
2014-02-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US20140051714A1
(en)
|
2011-04-22 |
2014-02-20 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
EP2796459A4
(en)
|
2011-12-23 |
2015-03-18 |
Meiji Seika Pharma Co Ltd |
NOVEL S1P RECEPTOR MODULATOR
|
|
EP3647783B1
(en)
|
2013-04-04 |
2022-12-21 |
Novartis AG |
Identifying patient response to s1p receptor modulator administration
|
|
EP3242666B9
(en)
|
2015-01-06 |
2024-12-25 |
Arena Pharmaceuticals, Inc. |
Compound for use in treating conditions related to the s1p1 receptor
|
|
IL285890B
(en)
|
2015-06-22 |
2022-07-01 |
Arena Pharm Inc |
Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid
|
|
MA47503A
(fr)
|
2017-02-16 |
2021-04-21 |
Arena Pharm Inc |
Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
|
|
MX2019009841A
(es)
|
2017-02-16 |
2020-01-30 |
Arena Pharm Inc |
Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
|
|
KR102859841B1
(ko)
|
2018-06-06 |
2025-09-12 |
아레나 파마슈티칼스, 인크. |
S1p1 수용체와 관련된 병태의 치료 방법
|
|
ES2951870T3
(es)
|
2018-10-03 |
2023-10-25 |
Arena Pharm Inc |
Etrasimod para su uso en procedimientos para el tratamiento de la esclerodermia
|
|
CN118649163A
(zh)
|
2018-11-30 |
2024-09-17 |
艾尼纳制药公司 |
治疗与s1p1受体有关的病况的方法
|
|
KR20210113298A
(ko)
|
2019-01-08 |
2021-09-15 |
아레나 파마슈티칼스, 인크. |
S1p₁ 수용체와 관련된 병태의 치료 방법
|