DK3189043T3 - Terapeutiske forbindelser som hæmmere af orexin-1-receptoren - Google Patents
Terapeutiske forbindelser som hæmmere af orexin-1-receptoren Download PDFInfo
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- DK3189043T3 DK3189043T3 DK15762678.9T DK15762678T DK3189043T3 DK 3189043 T3 DK3189043 T3 DK 3189043T3 DK 15762678 T DK15762678 T DK 15762678T DK 3189043 T3 DK3189043 T3 DK 3189043T3
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- Prior art keywords
- orexin
- receptor
- therapeutic compounds
- compounds inhibiting
- inhibiting
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB1415569.1A GB201415569D0 (en) | 2014-09-03 | 2014-09-03 | Therapeutic Compounds |
PCT/GB2015/052546 WO2016034882A1 (en) | 2014-09-03 | 2015-09-03 | Therapeutic compounds as inhibitors of the orexin-1 receptor |
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DK3189043T3 true DK3189043T3 (da) | 2020-12-14 |
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DK15762678.9T DK3189043T3 (da) | 2014-09-03 | 2015-09-03 | Terapeutiske forbindelser som hæmmere af orexin-1-receptoren |
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US (2) | US10611760B2 (da) |
EP (1) | EP3189043B1 (da) |
JP (1) | JP6776227B2 (da) |
KR (1) | KR102530580B1 (da) |
CN (1) | CN107074808B (da) |
AU (1) | AU2015310662C1 (da) |
BR (1) | BR112017004173A2 (da) |
CA (1) | CA2959942C (da) |
DK (1) | DK3189043T3 (da) |
EA (1) | EA038173B1 (da) |
ES (1) | ES2842230T3 (da) |
GB (2) | GB201415569D0 (da) |
IL (1) | IL250883B (da) |
MX (1) | MX2017002877A (da) |
MY (1) | MY199091A (da) |
PH (1) | PH12017500401A1 (da) |
SG (1) | SG11201701715PA (da) |
WO (1) | WO2016034882A1 (da) |
ZA (1) | ZA201701644B (da) |
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GB201415569D0 (en) | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
HUE058759T2 (hu) | 2016-03-10 | 2022-09-28 | Janssen Pharmaceutica Nv | Módszerek depresszió kezelésére orexin-2 receptor antagonisták alkalmazásával |
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JP6703131B2 (ja) * | 2016-04-15 | 2020-06-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なn−[(ピリミジニルアミノ)プロパニル]−およびn−[(ピリジニルアミノ)プロパニル]アリールカルボキサミド |
EP3442965B1 (en) * | 2016-04-15 | 2021-05-26 | Boehringer Ingelheim International GmbH | Novel n-[(heteroaryloxy)propanyl]heteroaryl carboxamides |
US10604511B2 (en) | 2016-04-15 | 2020-03-31 | Boehringer Ingelheim International Gmbh | N-[(pyrazinyloxy)propanyl]benzamides as antagonists of orexin subtype 1 receptor activity |
US10787432B2 (en) * | 2016-04-15 | 2020-09-29 | Boehringer Ingelheim International Gmbh | N-[(pyridyloxy)propanyl]benzamides |
CN110997660B (zh) * | 2017-07-31 | 2023-04-28 | 勃林格殷格翰国际有限公司 | N-[(嘧啶基氨基)丙烷基]-、n-[(吡啶基氨基)丙烷基]-和n-[(吡嗪基氨基)丙烷基]芳基甲酰胺 |
WO2019063605A1 (en) | 2017-09-28 | 2019-04-04 | Boehringer Ingelheim International Gmbh | NOVEL N- (2,2-DIFLUOROETHYL) -N - [(PYRIMIDINYLAMINO) PROPANYL] ARYLCARBOXAMIDES |
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-
2014
- 2014-09-03 GB GBGB1415569.1A patent/GB201415569D0/en not_active Ceased
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2015
- 2015-09-03 CN CN201580057696.4A patent/CN107074808B/zh active Active
- 2015-09-03 ES ES15762678T patent/ES2842230T3/es active Active
- 2015-09-03 MX MX2017002877A patent/MX2017002877A/es unknown
- 2015-09-03 CA CA2959942A patent/CA2959942C/en active Active
- 2015-09-03 US US15/508,392 patent/US10611760B2/en active Active
- 2015-09-03 BR BR112017004173A patent/BR112017004173A2/pt not_active Application Discontinuation
- 2015-09-03 EP EP15762678.9A patent/EP3189043B1/en active Active
- 2015-09-03 KR KR1020177008975A patent/KR102530580B1/ko active IP Right Grant
- 2015-09-03 SG SG11201701715PA patent/SG11201701715PA/en unknown
- 2015-09-03 MY MYPI2017700738A patent/MY199091A/en unknown
- 2015-09-03 GB GB1516146.6A patent/GB2533454A/en not_active Withdrawn
- 2015-09-03 DK DK15762678.9T patent/DK3189043T3/da active
- 2015-09-03 EA EA201790519A patent/EA038173B1/ru not_active IP Right Cessation
- 2015-09-03 WO PCT/GB2015/052546 patent/WO2016034882A1/en active Application Filing
- 2015-09-03 AU AU2015310662A patent/AU2015310662C1/en active Active
- 2015-09-03 JP JP2017513035A patent/JP6776227B2/ja active Active
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2017
- 2017-03-02 IL IL250883A patent/IL250883B/en active IP Right Grant
- 2017-03-03 PH PH12017500401A patent/PH12017500401A1/en unknown
- 2017-03-07 ZA ZA2017/01644A patent/ZA201701644B/en unknown
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2020
- 2020-03-10 US US16/814,328 patent/US12024509B2/en active Active
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