DK3131902T3 - Forbindelser som ROR-gamma-modulatorer - Google Patents
Forbindelser som ROR-gamma-modulatorer Download PDFInfo
- Publication number
- DK3131902T3 DK3131902T3 DK15718330.2T DK15718330T DK3131902T3 DK 3131902 T3 DK3131902 T3 DK 3131902T3 DK 15718330 T DK15718330 T DK 15718330T DK 3131902 T3 DK3131902 T3 DK 3131902T3
- Authority
- DK
- Denmark
- Prior art keywords
- ror
- compounds
- gamma modulators
- modulators
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461979231P | 2014-04-14 | 2014-04-14 | |
| PCT/US2015/025328 WO2015160654A1 (en) | 2014-04-14 | 2015-04-10 | Compounds as modulators of ror gamma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3131902T3 true DK3131902T3 (da) | 2019-09-02 |
Family
ID=52998264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15718330.2T DK3131902T3 (da) | 2014-04-14 | 2015-04-10 | Forbindelser som ROR-gamma-modulatorer |
Country Status (36)
| Country | Link |
|---|---|
| US (5) | US9242989B2 (da) |
| EP (2) | EP3418280B1 (da) |
| JP (2) | JP6282759B2 (da) |
| KR (2) | KR102410069B1 (da) |
| CN (3) | CN107266450B (da) |
| AP (1) | AP2016009403A0 (da) |
| AR (2) | AR100058A1 (da) |
| AU (2) | AU2015247983B2 (da) |
| BR (2) | BR122020020657B1 (da) |
| CA (1) | CA2944787C (da) |
| CL (1) | CL2016002421A1 (da) |
| CY (1) | CY1122012T1 (da) |
| DK (1) | DK3131902T3 (da) |
| EA (2) | EA031351B1 (da) |
| ES (1) | ES2744299T3 (da) |
| HK (2) | HK1244800A1 (da) |
| HR (1) | HRP20191579T1 (da) |
| HU (1) | HUE045847T2 (da) |
| IL (2) | IL247419B (da) |
| LT (1) | LT3131902T (da) |
| MA (1) | MA46373A (da) |
| ME (1) | ME03513B (da) |
| MX (1) | MX370780B (da) |
| MY (1) | MY182834A (da) |
| NZ (1) | NZ723530A (da) |
| PE (2) | PE20161572A1 (da) |
| PH (2) | PH12016502019A1 (da) |
| PL (1) | PL3131902T3 (da) |
| PT (1) | PT3131902T (da) |
| RS (1) | RS59170B1 (da) |
| SG (1) | SG11201608537SA (da) |
| SI (1) | SI3131902T1 (da) |
| TW (2) | TWI655192B (da) |
| UA (2) | UA120094C2 (da) |
| UY (1) | UY36077A (da) |
| WO (1) | WO2015160654A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME03513B (me) * | 2014-04-14 | 2020-04-20 | Boehringer Ingelheim Int | Jedinjenja kao modulatori za ror gama |
| FR3030518B1 (fr) * | 2014-12-19 | 2018-03-23 | Galderma Research & Development | Derives sulfonamides en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
| EP3845526A1 (en) | 2015-05-15 | 2021-07-07 | Aurigene Discovery Technologies Limited | Method for the preparation of tetrahydroquinolinone compounds having ror-gamma modulating activity |
| EP3356366B1 (en) * | 2015-10-01 | 2019-08-28 | Boehringer Ingelheim International GmbH | Pteridine derivatives as modulators of ror gamma |
| EA034514B1 (ru) | 2015-12-15 | 2020-02-14 | Астразенека Аб | Изоиндольные соединения |
| JP6899391B2 (ja) * | 2016-01-20 | 2021-07-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンマのモジュレータとしての化合物 |
| TWI705958B (zh) | 2016-12-05 | 2020-10-01 | 荷蘭商領導醫藥控股責任有限公司 | ＲＯＲγ調節子 |
| US20200031753A1 (en) | 2017-04-06 | 2020-01-30 | Boehringer Ingelheim International Gmbh | Cyclopropyl alkyl amines and process for their preparation |
| CN110730780A (zh) | 2017-06-14 | 2020-01-24 | 阿斯利康(瑞典)有限公司 | 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺 |
| CN109206346A (zh) * | 2017-07-01 | 2019-01-15 | 复旦大学 | 叔胺类衍生物或其盐及其制备方法和用途 |
| CN107903263B (zh) * | 2017-12-28 | 2019-11-12 | 山东铂源药业有限公司 | 一种帕布昔利布中间体的合成方法 |
| CN112135611B (zh) | 2018-05-03 | 2023-01-31 | 江苏恒瑞医药股份有限公司 | 作为维甲酸相关孤儿受体γ（RORγ）的调节剂的苯并咪唑衍生物及其药物用途 |
| CN112930336A (zh) | 2018-10-18 | 2021-06-08 | 勃林格殷格翰国际有限公司 | 光学活性的1-环丙基烷基-1-胺的可放大合成 |
| US20230014730A1 (en) | 2019-09-23 | 2023-01-19 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| CN114502535B (zh) | 2019-10-31 | 2024-04-12 | 江苏恒瑞医药股份有限公司 | 一种RORγ调节剂的酸加成盐 |
| WO2022106549A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Crystalline salts of a ror gamma inhibitor |
| WO2022106551A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Co-crystals of a ror gamma inhibitor |
| WO2022106548A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Solid forms of a ror gamma inhibitor |
| WO2022106547A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Process for synthesising a ror gamma inhibitor |
| WO2022106550A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Crystalline polymorphic form of a ror gamma inhibitor |
| CN117003757A (zh) * | 2022-05-07 | 2023-11-07 | 苏州浦合医药科技有限公司 | 取代的双环杂芳基化合物作为usp1抑制剂 |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
| WO2009022185A2 (en) * | 2007-08-16 | 2009-02-19 | Astrazeneca Ab | 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use |
| JP5507567B2 (ja) | 2008-09-26 | 2014-05-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物 |
| KR20120087923A (ko) | 2009-10-21 | 2012-08-07 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃｃｒ１ 수용체 길항제로서의 인다졸 및 피라졸로피리딘 화합물 |
| WO2012167046A1 (en) * | 2011-06-01 | 2012-12-06 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
| CN103930425B (zh) * | 2012-05-14 | 2016-04-27 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
| ME03513B (me) * | 2014-04-14 | 2020-04-20 | Boehringer Ingelheim Int | Jedinjenja kao modulatori za ror gama |
| EP3356366B1 (en) * | 2015-10-01 | 2019-08-28 | Boehringer Ingelheim International GmbH | Pteridine derivatives as modulators of ror gamma |
| JP6899391B2 (ja) * | 2016-01-20 | 2021-07-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンマのモジュレータとしての化合物 |
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2015
- 2015-04-10 ME MEP-2019-233A patent/ME03513B/me unknown
- 2015-04-10 RS RSP20191083 patent/RS59170B1/sr unknown
- 2015-04-10 LT LTEP15718330.2T patent/LT3131902T/lt unknown
- 2015-04-10 EP EP18177902.6A patent/EP3418280B1/en active Active
- 2015-04-10 KR KR1020167031654A patent/KR102410069B1/ko active IP Right Grant
- 2015-04-10 UA UAA201610804A patent/UA120094C2/uk unknown
- 2015-04-10 EA EA201691978A patent/EA031351B1/ru not_active IP Right Cessation
- 2015-04-10 MA MA046373A patent/MA46373A/fr unknown
- 2015-04-10 PT PT15718330T patent/PT3131902T/pt unknown
- 2015-04-10 MX MX2016013342A patent/MX370780B/es active IP Right Grant
- 2015-04-10 MY MYPI2016001598A patent/MY182834A/en unknown
- 2015-04-10 EP EP15718330.2A patent/EP3131902B1/en active Active
- 2015-04-10 PL PL15718330T patent/PL3131902T3/pl unknown
- 2015-04-10 SI SI201530865T patent/SI3131902T1/sl unknown
- 2015-04-10 PE PE2016001963A patent/PE20161572A1/es unknown
- 2015-04-10 DK DK15718330.2T patent/DK3131902T3/da active
- 2015-04-10 CN CN201710445827.7A patent/CN107266450B/zh active Active
- 2015-04-10 JP JP2016562565A patent/JP6282759B2/ja active Active
- 2015-04-10 ES ES15718330T patent/ES2744299T3/es active Active
- 2015-04-10 EA EA201890329A patent/EA035063B1/ru not_active IP Right Cessation
- 2015-04-10 AP AP2016009403A patent/AP2016009403A0/en unknown
- 2015-04-10 SG SG11201608537SA patent/SG11201608537SA/en unknown
- 2015-04-10 PE PE2020001484A patent/PE20211002A1/es unknown
- 2015-04-10 WO PCT/US2015/025328 patent/WO2015160654A1/en active Application Filing
- 2015-04-10 HU HUE15718330A patent/HUE045847T2/hu unknown
- 2015-04-10 UA UAA201803569A patent/UA121255C2/uk unknown
- 2015-04-10 AU AU2015247983A patent/AU2015247983B2/en not_active Ceased
- 2015-04-10 CN CN201710445005.9A patent/CN107266454B/zh active Active
- 2015-04-10 CA CA2944787A patent/CA2944787C/en active Active
- 2015-04-10 BR BR122020020657-8A patent/BR122020020657B1/pt active IP Right Grant
- 2015-04-10 US US14/683,682 patent/US9242989B2/en active Active
- 2015-04-10 BR BR112016021962A patent/BR112016021962A2/pt not_active IP Right Cessation
- 2015-04-10 NZ NZ723530A patent/NZ723530A/en unknown
- 2015-04-10 CN CN201580016630.0A patent/CN106132965B/zh active Active
- 2015-04-10 KR KR1020207010364A patent/KR102410076B1/ko active IP Right Grant
- 2015-04-13 AR ARP150101103A patent/AR100058A1/es not_active Application Discontinuation
- 2015-04-13 UY UY0001036077A patent/UY36077A/es not_active Application Discontinuation
- 2015-04-13 TW TW104111832A patent/TWI655192B/zh not_active IP Right Cessation
- 2015-04-13 TW TW107130729A patent/TWI652268B/zh not_active IP Right Cessation
- 2015-11-20 US US14/946,873 patent/US20160075706A1/en not_active Abandoned
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2016
- 2016-08-22 IL IL247419A patent/IL247419B/en active IP Right Grant
- 2016-09-20 US US15/270,029 patent/US9598415B2/en active Active
- 2016-09-27 CL CL2016002421A patent/CL2016002421A1/es unknown
- 2016-10-11 PH PH12016502019A patent/PH12016502019A1/en unknown
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2017
- 2017-01-23 HK HK18104172.2A patent/HK1244800A1/zh unknown
- 2017-01-23 HK HK18104174.0A patent/HK1244801A1/zh unknown
- 2017-02-07 US US15/426,208 patent/US20180022749A1/en not_active Abandoned
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2018
- 2018-01-24 JP JP2018009384A patent/JP6463855B2/ja active Active
- 2018-09-06 US US16/123,139 patent/US20190002465A1/en not_active Abandoned
- 2018-12-20 IL IL26387818A patent/IL263878B/en active IP Right Grant
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2019
- 2019-04-30 AU AU2019203027A patent/AU2019203027B2/en not_active Ceased
- 2019-09-02 HR HRP20191579 patent/HRP20191579T1/hr unknown
- 2019-09-09 CY CY20191100942T patent/CY1122012T1/el unknown
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2020
- 2020-02-04 PH PH12020500252A patent/PH12020500252A1/en unknown
- 2020-07-21 AR ARP200102050A patent/AR119454A2/es unknown
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