US7119184B2
(en)
*
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
JP4148662B2
(ja)
*
|
2000-08-10 |
2008-09-10 |
第一三共株式会社 |
ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬
|
JP4151751B2
(ja)
*
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
AU2001293687A1
(en)
|
2000-10-04 |
2002-04-15 |
Cureon A/S |
Improved synthesis of purine locked nucleic acid analogues
|
GB0114719D0
(en)
*
|
2001-06-15 |
2001-08-08 |
Glaxo Group Ltd |
Compound
|
WO2003033696A1
(fr)
*
|
2001-10-18 |
2003-04-24 |
Sankyo Company, Limited |
Compose antisens vegf
|
EP1481983A4
(en)
*
|
2002-02-13 |
2008-04-02 |
Takeshi Imanishi |
NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
EP1560840B1
(en)
|
2002-11-05 |
2015-05-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
AU2013201763B2
(en)
*
|
2002-11-18 |
2015-05-07 |
Roche Innovation Center Copenhagen A/S |
Amino-LNA, thio-LNA and alpha-L-oxy-LN
|
DK2284269T3
(da)
*
|
2002-11-18 |
2017-10-23 |
Roche Innovation Ct Copenhagen As |
Antisense-design
|
JP5132025B2
(ja)
*
|
2002-11-19 |
2013-01-30 |
第一三共株式会社 |
新規2’,5’−オリゴアデニル酸類縁体
|
TWI347948B
(en)
*
|
2002-11-19 |
2011-09-01 |
Sankyo Co |
Novel 2',5'-oligoadenylic acid compositions
|
CA3001404C
(en)
*
|
2002-11-25 |
2020-07-28 |
Masafumi Matsuo |
Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors
|
DK1639130T3
(da)
|
2003-06-20 |
2012-07-09 |
Exiqon As |
Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
WO2005021570A1
(ja)
*
|
2003-08-28 |
2005-03-10 |
Gene Design, Inc. |
N−0結合性架橋構造型新規人工核酸
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US7480382B2
(en)
*
|
2003-09-30 |
2009-01-20 |
Microsoft Corporation |
Image file container
|
GB0324854D0
(en)
*
|
2003-10-24 |
2003-11-26 |
Expresson Biosystems Ltd |
App/ena antisense
|
US7906639B2
(en)
|
2003-11-07 |
2011-03-15 |
Sankyo Company, Limited |
Oligonucleotides having a 2′-O,4′-C-ethylene nucleotide in the third position of the 3′-end
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
WO2005116207A1
(ja)
*
|
2004-05-28 |
2005-12-08 |
Sankyo Company, Limited |
テロメラーゼ阻害enaオリゴヌクレオチド
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006059507A1
(ja)
*
|
2004-11-30 |
2006-06-08 |
Sankyo Company, Limited |
11β-HSD1アンチセンス化合物
|
US20090264635A1
(en)
*
|
2005-03-25 |
2009-10-22 |
Applera Corporation |
Methods and compositions for depleting abundant rna transcripts
|
WO2007027894A2
(en)
|
2005-08-29 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds having enhanced anti-microrna activity
|
US8883162B2
(en)
*
|
2005-10-19 |
2014-11-11 |
Ibc Pharmaceuticals, Inc. |
Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
|
US9862770B2
(en)
|
2005-10-19 |
2018-01-09 |
Ibc Pharmaceuticals, Inc. |
Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
|
US20100226884A1
(en)
|
2009-01-20 |
2010-09-09 |
Immunomedics, Inc. |
Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
|
WO2007064945A2
(en)
|
2005-12-01 |
2007-06-07 |
Pronai Therapeutics, Inc. |
Cancer therapies and pharmaceutical compositions used therein
|
CA2642657A1
(en)
*
|
2005-12-09 |
2007-06-14 |
Riken |
Method for replicating nucleic acids and novel unnatural base pairs
|
US8288354B2
(en)
*
|
2005-12-28 |
2012-10-16 |
The Scripps Research Institute |
Natural antisense and non-coding RNA transcripts as drug targets
|
DK2314594T3
(da)
|
2006-01-27 |
2014-10-27 |
Isis Pharmaceuticals Inc |
6-modificerede bicykliske nukleinsyreanaloger
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
マイクロrnaの調節に使用するためのオリゴマー化合物及び組成物
|
EP2505647A1
(en)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of DGAT2
|
US8188059B2
(en)
|
2006-05-05 |
2012-05-29 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of GCGR
|
CN101490074B
(zh)
|
2006-05-11 |
2013-06-26 |
Isis制药公司 |
5’-修饰的双环核酸类似物
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
JP5665317B2
(ja)
|
2006-10-18 |
2015-02-04 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
アンチセンス化合物
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
EP2455471A3
(en)
*
|
2006-11-27 |
2012-09-12 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
WO2008104978A2
(en)
*
|
2007-02-28 |
2008-09-04 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
WO2008150729A2
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
US20110046206A1
(en)
*
|
2007-06-22 |
2011-02-24 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
US8278283B2
(en)
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
MX2010003465A
(es)
|
2007-10-02 |
2010-07-05 |
Amgen Inc |
Incremento de eritropoyetina utilizando acidos nucleicos que hibridan para micro-arn y precursores de los mismos.
|
WO2009044392A2
(en)
|
2007-10-03 |
2009-04-09 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
WO2009074990A2
(en)
*
|
2007-12-12 |
2009-06-18 |
Quark Pharmaceuticals, Inc. |
Rtp801l sirna compounds and methods of use thereof
|
EP2242854A4
(en)
*
|
2008-01-15 |
2012-08-15 |
Quark Pharmaceuticals Inc |
COMPOUNDS AND USES THEREOF
|
WO2009100320A2
(en)
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
EP3643782A1
(en)
|
2008-02-11 |
2020-04-29 |
Phio Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
BRPI0909270A2
(pt)
*
|
2008-03-20 |
2015-08-11 |
Quark Pharmaceuticals Inc |
Compostos de sirna para inibição de rtp801
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
US8278287B2
(en)
*
|
2008-04-15 |
2012-10-02 |
Quark Pharmaceuticals Inc. |
siRNA compounds for inhibiting NRF2
|
US8222221B2
(en)
|
2008-06-04 |
2012-07-17 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small RNA targeting of gene promoters
|
WO2009147684A2
(en)
|
2008-06-06 |
2009-12-10 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
US8901095B2
(en)
|
2008-07-29 |
2014-12-02 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
GB2465902B
(en)
*
|
2008-08-25 |
2010-12-08 |
Excaliard Pharmaceuticals Inc |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
WO2010033246A1
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
EP2356129B1
(en)
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
CA2739464C
(en)
*
|
2008-10-03 |
2020-03-31 |
Opko Curna, Llc |
Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
CN102317458B
(zh)
|
2008-12-04 |
2018-01-02 |
库尔纳公司 |
通过红细胞生成素(epo)天然反义转录物的抑制对epo相关疾病的治疗
|
MX2011005918A
(es)
|
2008-12-04 |
2011-06-17 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con un gen supresor de tumor mediante inhibicion del transcrito antisentido natural para el gen.
|
JP5971948B2
(ja)
|
2008-12-04 |
2016-08-17 |
クルナ・インコーポレーテッド |
Vegfに対する天然アンチセンス転写物の抑制による血管内皮増殖因子(vegf)関連疾患の治療
|
US8592386B2
(en)
|
2008-12-17 |
2013-11-26 |
Sarepta Therapeutics, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
US20110288155A1
(en)
|
2008-12-18 |
2011-11-24 |
Elena Feinstein |
Sirna compounds and methods of use thereof
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
CA2752237C
(en)
|
2009-02-12 |
2020-03-24 |
Opko Curna, Llc |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
US9708604B2
(en)
|
2009-03-17 |
2017-07-18 |
Curna, Inc. |
Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
|
EP2421972A2
(en)
|
2009-04-24 |
2012-02-29 |
The Board of Regents of The University of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
DE102009019476A1
(de)
*
|
2009-05-04 |
2010-11-11 |
Biametrics Marken Und Rechte Gmbh |
Wiedererkennbarer Träger für optische Meßverfahren
|
CN102459596B
(zh)
|
2009-05-06 |
2016-09-07 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
KR101722541B1
(ko)
|
2009-05-06 |
2017-04-04 |
큐알엔에이, 인크. |
Ttp에 대한 천연 안티센스 전사체의 억제에 의한 트리스테트라프롤린 관련된 질환의 치료
|
EP2427554B1
(en)
|
2009-05-08 |
2016-11-16 |
CuRNA, Inc. |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
|
KR101749356B1
(ko)
|
2009-05-18 |
2017-07-06 |
큐알엔에이, 인크. |
재편성 인자에 대한 천연 안티센스 전사체의 억제에 의한 재편성 인자 관련된 질환의 치료
|
CA2762987A1
(en)
|
2009-05-22 |
2010-11-25 |
Joseph Collard |
Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3
|
KR101704988B1
(ko)
|
2009-05-28 |
2017-02-08 |
큐알엔에이, 인크. |
항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료
|
EP3276004B1
(en)
|
2009-06-08 |
2020-03-18 |
Quark Pharmaceuticals, Inc. |
Methods for treating chronic kidney disease
|
WO2010148065A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of paraoxonase 1 (pon1) related diseases by inhibition of natural antisense transcript to pon1
|
ES2620960T3
(es)
|
2009-06-16 |
2017-06-30 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con un gen de colágeno mediante la inhibición de un transcrito antisentido natural a un gen de colágeno
|
ES2618894T3
(es)
|
2009-06-24 |
2017-06-22 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
|
CN102482672B
(zh)
|
2009-06-26 |
2016-11-09 |
库尔纳公司 |
通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
|
CA2768947C
(en)
|
2009-07-24 |
2018-06-19 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
EP2462229B1
(en)
|
2009-08-05 |
2016-05-11 |
CuRNA, Inc. |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
JP6189594B2
(ja)
|
2009-08-11 |
2017-08-30 |
クルナ・インコーポレーテッド |
アディポネクチン(adipoq)に対する天然アンチセンス転写物の抑制によるアディポネクチン(adipoq)関連疾患の治療
|
US8791087B2
(en)
|
2009-08-21 |
2014-07-29 |
Curna, Inc. |
Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP
|
US9023822B2
(en)
|
2009-08-25 |
2015-05-05 |
Curna, Inc. |
Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
|
CA2775111C
(en)
|
2009-09-25 |
2019-12-31 |
Opko Curna, Llc |
Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
|
US20120220649A1
(en)
|
2009-10-30 |
2012-08-30 |
Daiichi Sankyo Company, Limited |
Modified double-stranded polynucleotide
|
WO2011053994A1
(en)
|
2009-11-02 |
2011-05-05 |
Alnylam Pharmaceuticals, Inc. |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
WO2011072091A1
(en)
|
2009-12-09 |
2011-06-16 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the cns
|
TWI543763B
(zh)
|
2009-12-09 |
2016-08-01 |
日東電工股份有限公司 |
Hsp47表現之調節
|
US9173895B2
(en)
|
2009-12-16 |
2015-11-03 |
Curna, Inc. |
Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1
|
CA2782375C
(en)
|
2009-12-23 |
2023-10-31 |
Opko Curna, Llc |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
CN102869776B
(zh)
|
2009-12-23 |
2017-06-23 |
库尔纳公司 |
通过抑制肝细胞生长因子(hgf)的天然反义转录物而治疗hgf相关疾病
|
US8921334B2
(en)
|
2009-12-29 |
2014-12-30 |
Curna, Inc. |
Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1
|
WO2011090741A2
(en)
|
2009-12-29 |
2011-07-28 |
Opko Curna, Llc |
TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
|
CA2785727C
(en)
|
2009-12-31 |
2020-01-07 |
Curna, Inc. |
Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
|
CA2785832A1
(en)
|
2010-01-04 |
2011-07-07 |
Curna, Inc. |
Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
|
JP5963680B2
(ja)
|
2010-01-06 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
CA2786535C
(en)
|
2010-01-11 |
2019-03-26 |
Curna, Inc. |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR101853510B1
(ko)
|
2010-01-25 |
2018-06-20 |
큐알엔에이, 인크. |
Rnase h1에 대한 천연 안티센스 전사체의 억제에 의한 rnase h1과 관련된 질환의 치료
|
WO2011097388A1
(en)
|
2010-02-03 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Selective inhibition of polyglutamine protein expression
|
EP2539452B1
(en)
|
2010-02-22 |
2016-07-27 |
CuRNA, Inc. |
Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
|
US20130005796A1
(en)
|
2010-03-12 |
2013-01-03 |
Daiichi Sankyo Company, Limited |
Method for proliferating cardiomyocytes using micro-rna
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
IL265674B2
(en)
|
2010-03-24 |
2024-05-01 |
Phio Pharm Corp |
Rana disorder in cutaneous and fibrotic symptoms
|
EP2550001B1
(en)
|
2010-03-24 |
2019-05-22 |
Phio Pharmaceuticals Corp. |
Rna interference in ocular indications
|
WO2011119852A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
CA2795145C
(en)
|
2010-04-02 |
2019-01-22 |
Curna, Inc. |
Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
|
WO2011127337A2
(en)
|
2010-04-09 |
2011-10-13 |
Opko Curna Llc |
Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
|
EP3173419A1
(en)
|
2010-04-28 |
2017-05-31 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
|
KR101992076B1
(ko)
|
2010-05-03 |
2019-06-21 |
큐알엔에이, 인크. |
시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
EP2576783B1
(en)
|
2010-05-26 |
2017-11-29 |
CuRNA, Inc. |
Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
|
ES2664585T3
(es)
|
2010-05-26 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con metionina sulfóxido reductasa (MSRA) mediante inhibición del transcrito antisentido natural a MSRA
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR101914309B1
(ko)
|
2010-06-23 |
2018-11-02 |
큐알엔에이, 인크. |
전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
|
DK2593547T3
(da)
|
2010-07-14 |
2018-02-26 |
Curna Inc |
Behandling af Discs large homolog- (DLG) relaterede sygdomme ved hæmning af naturligt antisense transskript til DLG
|
EP2412724A1
(en)
|
2010-07-29 |
2012-02-01 |
Centre National de la Recherche Scientifique (C.N.R.S) |
Regulation of Glypican 4 activity to modulate the fate of stem cells and uses thereof
|
CN103210086B
(zh)
|
2010-10-06 |
2017-06-09 |
库尔纳公司 |
通过抑制唾液酸酶4(neu4)的天然反义转录物而治疗neu4相关疾病
|
CN103180445B
(zh)
|
2010-10-22 |
2018-02-16 |
库尔纳公司 |
通过抑制α‑L‑艾杜糖醛酸酶(IDUA)的天然反义转录物而治疗IDUA相关疾病
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
CA2818824A1
(en)
|
2010-11-23 |
2012-05-31 |
Joseph Collard |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
CN103370416A
(zh)
|
2010-12-02 |
2013-10-23 |
第一三共株式会社 |
修饰的单链多核苷酸
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
EP2681314B1
(en)
|
2011-03-03 |
2017-11-01 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating lung disease and injury
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
CA2828544A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
JP6188686B2
(ja)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
フラタキシン(fxn)への天然アンチセンス転写物の阻害によるfxn関連疾患の治療
|
WO2012174187A2
(en)
*
|
2011-06-15 |
2012-12-20 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (hiv)
|
WO2013022984A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
MX365525B
(es)
|
2011-09-06 |
2019-06-06 |
Curna Inc |
Compuestos que regulan la expresión de subunidades alfa de canales de sodio regulados por voltaje en enfermedades relacionadas con epilepsia mioclónica severa de la infancia.
|
US9580708B2
(en)
|
2011-09-14 |
2017-02-28 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotides compounds
|
CA2851296C
(en)
|
2011-11-03 |
2020-08-25 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for neuroprotection
|
EP2790736B1
(en)
|
2011-12-12 |
2018-01-31 |
Oncoimmunin, Inc. |
In vivo delivery of oligonucleotides
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
HUE040179T2
(hu)
|
2012-03-15 |
2019-02-28 |
Curna Inc |
Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
|
US10273474B2
(en)
|
2012-03-30 |
2019-04-30 |
Washington University |
Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
EP3336189A1
(en)
|
2012-04-20 |
2018-06-20 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US10059941B2
(en)
|
2012-05-16 |
2018-08-28 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
DK2850189T3
(da)
|
2012-05-16 |
2019-02-25 |
Translate Bio Ma Inc |
Sammensætninger og fremgangsmåder til modulering af genekspression
|
CA2873779A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating mecp2 expression
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
JP2013256452A
(ja)
*
|
2012-06-11 |
2013-12-26 |
Kawaken Fine Chem Co Ltd |
メラニン産生抑制剤とその組成物
|
WO2013191129A1
(ja)
|
2012-06-18 |
2013-12-27 |
第一三共株式会社 |
ヌクレオシド類縁体の製造中間体及びその製造方法
|
WO2014045126A2
(en)
|
2012-09-18 |
2014-03-27 |
Uti Limited Partnership |
Treatment of pain by inhibition of usp5 de-ubiquitinase
|
US9695418B2
(en)
|
2012-10-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR20150087270A
(ko)
|
2012-11-05 |
2015-07-29 |
프로나이 테라퓨틱스, 인코포레이티드 |
Bcl2 발현 조절에 의한 암치료용 바이오마커 이용 방법
|
EP2961853B1
(en)
|
2013-02-28 |
2018-09-19 |
The Board of Regents of The University of Texas System |
Methods for classifying a cancer as susceptible to tmepai-directed therapies and treating such cancers
|
WO2014143158A1
(en)
|
2013-03-13 |
2014-09-18 |
The Broad Institute, Inc. |
Compositions and methods for labeling of agents
|
CN111254145A
(zh)
|
2013-03-14 |
2020-06-09 |
Ionis制药公司 |
用于调节tau表达的组合物和方法
|
US9273349B2
(en)
|
2013-03-14 |
2016-03-01 |
Affymetrix, Inc. |
Detection of nucleic acids
|
US9822418B2
(en)
|
2013-04-22 |
2017-11-21 |
Icahn School Of Medicine At Mount Sinai |
Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis
|
SI2992009T1
(sl)
|
2013-05-01 |
2020-10-30 |
Ionis Pharmaceuticals, Inc. |
Sestavki in postopki za moduliranje izražanja apolipoproteina (A)
|
TWI772856B
(zh)
*
|
2013-07-19 |
2022-08-01 |
美商百健Ma公司 |
用於調節τ蛋白表現之組合物
|
JP2016534035A
(ja)
|
2013-10-04 |
2016-11-04 |
ラナ セラピューティクス インコーポレイテッド |
筋萎縮性側索硬化症を治療するための組成物及び方法
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
WO2015075166A1
(en)
|
2013-11-22 |
2015-05-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of a bacterial infection
|
JP6772062B2
(ja)
|
2013-12-02 |
2020-10-21 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
癌の免疫療法
|
WO2015118407A2
(en)
|
2014-01-29 |
2015-08-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
|
SI3126499T1
(sl)
|
2014-04-01 |
2020-09-30 |
Biogen Ma Inc. |
Sestave za moduliranje izražanja SOD-1
|
EP3137119B1
(en)
|
2014-04-28 |
2020-07-01 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using a nucleic acid targeting mdm2
|
DK3137476T3
(da)
|
2014-04-28 |
2019-11-18 |
Ionis Pharmaceuticals Inc |
Linker-modificerede oligomerforbindelser
|
RU2701645C2
(ru)
|
2014-05-01 |
2019-09-30 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии фактора комплемента в
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
JP6562517B2
(ja)
*
|
2014-07-31 |
2019-08-21 |
国立大学法人大阪大学 |
架橋型ヌクレオシドおよびヌクレオチド
|
IL234246A0
(en)
|
2014-08-21 |
2014-11-30 |
Omrix Biopharmaceuticals Ltd |
Stabilized thrombin
|
KR102506169B1
(ko)
|
2014-09-05 |
2023-03-08 |
피오 파마슈티칼스 코프. |
Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
|
KR102620328B1
(ko)
|
2014-10-03 |
2024-01-02 |
콜드스프링하버러보러토리 |
핵 유전자 산출량의 표적화 증강
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
WO2016100716A1
(en)
|
2014-12-18 |
2016-06-23 |
Vasant Jadhav |
Reversirtm compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
WO2017007813A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
CA3205381A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
EP3341479B1
(en)
|
2015-08-24 |
2019-12-18 |
Roche Innovation Center Copenhagen A/S |
Lna-g process
|
KR102422625B1
(ko)
|
2015-10-09 |
2022-07-20 |
유니버시티 오브 사우스앰톤 |
유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝
|
WO2017070151A1
(en)
|
2015-10-19 |
2017-04-27 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
US11273151B2
(en)
|
2015-11-04 |
2022-03-15 |
Icahn School Of Medicine At Mount Sinai |
Methods of treating tumors and cancer, and identifying candidate subjects for such treatment
|
SI3374509T1
(sl)
|
2015-11-12 |
2021-04-30 |
F. Hoffmann-La Roche Ag |
Oligonukleotidi za indukcijo očetovske ekspresije UBE3A
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
US11083745B2
(en)
|
2015-12-14 |
2021-08-10 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and Dravet Syndrome
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
CN114085836B
(zh)
|
2016-03-14 |
2024-01-26 |
豪夫迈·罗氏有限公司 |
用于减少pd-l1表达的寡核苷酸
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
US11248019B2
(en)
|
2016-04-14 |
2022-02-15 |
Hoffmann-La Roche Inc. |
Trityl-mono-GalNAc compounds and their use
|
WO2017189730A1
(en)
|
2016-04-26 |
2017-11-02 |
Icahn School Of Medicine At Mount Sinai |
Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
|
EP3471781A4
(en)
|
2016-06-17 |
2020-05-06 |
Ionis Pharmaceuticals, Inc. |
MODULATING THE GYS1 EXPRESSION
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
CA3026855A1
(en)
|
2016-07-01 |
2018-01-04 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
US11253601B2
(en)
|
2016-07-11 |
2022-02-22 |
Translate Bio Ma, Inc. |
Nucleic acid conjugates and uses thereof
|
AU2017326372B2
(en)
|
2016-09-14 |
2023-12-07 |
Janssen Biopharma, Inc. |
Modified oligonucleotides and methods of use
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
DELIVERING THERAPEUTIC RNAS VIA ARRDC1-MEDIATED MICROVESICLES
|
WO2018087200A1
(en)
|
2016-11-11 |
2018-05-17 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
US11230709B2
(en)
|
2016-12-28 |
2022-01-25 |
National University Corporation Kobe University |
Therapeutic drug for Alport's syndrome
|
MX2019008252A
(es)
|
2017-01-10 |
2019-09-06 |
Arrowhead Pharmaceuticals Inc |
Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso.
|
US20190345495A1
(en)
|
2017-01-13 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
EP3568478A1
(en)
|
2017-01-13 |
2019-11-20 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
US20200216845A1
(en)
|
2017-01-13 |
2020-07-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
US20190367920A1
(en)
|
2017-01-13 |
2019-12-05 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb1 expression
|
WO2018130585A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
US11377468B2
(en)
|
2017-03-10 |
2022-07-05 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
BR112019018615B1
(pt)
*
|
2017-03-10 |
2021-11-16 |
Lakewood Amedex, Inc. |
Composto antimicrobiano e sua composiqao farmaceutica
|
KR102520654B1
(ko)
|
2017-03-10 |
2023-04-10 |
고쿠리츠켄큐카이하츠호진 고쿠리츠 세이쿠이료켄큐센타 |
안티센스 올리고뉴클레오티드 및 당원병 Ia형 예방 또는 치료용 조성물
|
US11795192B2
(en)
|
2017-03-10 |
2023-10-24 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
JP7306653B2
(ja)
|
2017-03-17 |
2023-07-11 |
国立大学法人千葉大学 |
構造強化されたS-TuDを用いた新規がん治療法
|
WO2018212271A1
(ja)
|
2017-05-18 |
2018-11-22 |
国立大学法人京都大学 |
脊髄小脳変性症36型の予防又は治療用組成物
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
JPWO2019009299A1
(ja)
|
2017-07-05 |
2020-05-07 |
国立大学法人大阪大学 |
α−シヌクレイン発現抑制するENAアンチセンスオリゴヌクレオチド
|
US11028390B2
(en)
|
2017-07-10 |
2021-06-08 |
Osaka University |
Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
LT3673080T
(lt)
|
2017-08-25 |
2023-12-27 |
Stoke Therapeutics, Inc. |
Priešprasminiai oligomerai, skirti būklėms ir ligoms gydyti
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
US20200270611A1
(en)
|
2017-09-14 |
2020-08-27 |
Janssen Biopharma, Inc. |
Galnac derivatives
|
CN111226114A
(zh)
|
2017-10-13 |
2020-06-02 |
罗氏创新中心哥本哈根有限公司 |
用部分立体限定的寡核苷酸子文库鉴定反义寡核苷酸改进的立体限定硫代磷酸酯寡核苷酸变体的方法
|
US10953034B2
(en)
|
2017-10-16 |
2021-03-23 |
Hoffmann-La Roche Inc. |
Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
|
US11261445B2
(en)
|
2017-10-17 |
2022-03-01 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Combination treatment for cystic fibrosis
|
WO2019111791A1
(ja)
*
|
2017-12-07 |
2019-06-13 |
第一三共株式会社 |
ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド
|
JP2021505175A
(ja)
|
2017-12-11 |
2021-02-18 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Fndc3bの発現を調節するためのオリゴヌクレオチド
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
JP2021507253A
(ja)
|
2017-12-21 |
2021-02-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Htra1 rnaアンタゴニストについてのコンパニオン診断
|
WO2019122277A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Novel thiophosphoramidites
|
KR20200104347A
(ko)
|
2017-12-22 |
2020-09-03 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
포스포로디티오에이트 인터뉴클레오시드 연결을 포함하는 갭머 올리고뉴클레오티드
|
EP3728592B1
(en)
|
2017-12-22 |
2024-05-29 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
US20210095274A1
(en)
|
2018-01-10 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating pias4 expression
|
CN111556894A
(zh)
|
2018-01-12 |
2020-08-18 |
哥本哈根罗氏创新中心 |
用于调控gsk3b表达的寡核苷酸
|
BR112020012921A2
(pt)
|
2018-01-12 |
2020-12-08 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotídeos antissenso de alfa-sinucleína e usos dos mesmos
|
PE20211749A1
(es)
|
2018-01-12 |
2021-09-06 |
Bristol Myers Squibb Co |
Oligonucleotidos antisentido que actuan sobre alfa-sinucleina, y usos de estos
|
SG11202006526YA
(en)
|
2018-01-12 |
2020-08-28 |
Bristol Myers Squibb Co |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
EP3740574A1
(en)
|
2018-01-17 |
2020-11-25 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating erc1 expression
|
US20210095277A1
(en)
|
2018-01-18 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting srebp1
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
AU2019219194A1
(en)
|
2018-02-09 |
2020-08-06 |
Genentech, Inc. |
Oligonucleotides for modulating TMEM106B expression
|
US11058767B2
(en)
|
2018-02-21 |
2021-07-13 |
Bristol-Myers Squibb Company |
CAMK2D antisense oligonucleotides and uses thereof
|
CN111511915A
(zh)
|
2018-03-09 |
2020-08-07 |
第一三共株式会社 |
糖原病Ia型治疗药
|
EA202092156A1
(ru)
|
2018-03-13 |
2021-04-01 |
Янссен Фармацевтика Нв |
Модифицированные олигонуклеотиды и способы применения в лечении таупатий
|
RU2020135289A
(ru)
|
2018-04-05 |
2022-05-05 |
Ф. Хоффманн-Ля Рош Аг |
Применение ингибиторов fubp1 для лечения инфекции вирусом гепатита в
|
EP3790990A1
(en)
|
2018-05-07 |
2021-03-17 |
Roche Innovation Center Copenhagen A/S |
Quality control of lna oligonucleotide therapeutics using massively parallel sequencing
|
EP3790970A1
(en)
|
2018-05-07 |
2021-03-17 |
Alnylam Pharmaceuticals Inc. |
Extrahepatic delivery
|
WO2019215175A1
(en)
|
2018-05-08 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
WO2019219723A1
(en)
|
2018-05-18 |
2019-11-21 |
F. Hoffmann-La Roche Ag |
Pharmaceutical compositions for treatment of microrna related diseases
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
WO2019233921A1
(en)
|
2018-06-05 |
2019-12-12 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating atxn2 expression
|
BR112020023503A2
(pt)
|
2018-06-13 |
2021-03-30 |
Daiichi Sankyo Company, Limited |
Agente terapêutico contra disfunção do miocárdio
|
CN112566640A
(zh)
|
2018-06-18 |
2021-03-26 |
罗切斯特大学 |
治疗精神分裂症和其他神经精神病症的方法
|
CA3103675A1
(en)
|
2018-06-21 |
2019-12-26 |
University Of Rochester |
Methods of treating or inhibiting onset of huntington's disease
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
CR20210179A
(es)
|
2018-07-03 |
2022-05-23 |
Hoffmann La Roche |
OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
|
JP7340794B2
(ja)
|
2018-07-04 |
2023-09-08 |
学校法人 愛知医科大学 |
タウのスプライシングを制御するアンチセンスオリゴヌクレオチド及びその用途
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
CR20210015A
(es)
|
2018-07-13 |
2021-03-22 |
Hoffmann La Roche |
Oligonucleótidos para modular la expresión de rtel 1
|
MX2020013270A
(es)
|
2018-07-31 |
2021-02-18 |
Roche Innovation Ct Copenhagen As |
Oligonucleotidos que comprenden enlace internucleosidico de fosforotritioato.
|
ES2924362T3
(es)
|
2018-07-31 |
2022-10-06 |
Roche Innovation Ct Copenhagen As |
Oligonucleótidos que comprenden un enlace internucleosídico fosforotritioato
|
US11911484B2
(en)
|
2018-08-02 |
2024-02-27 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
CN112585280A
(zh)
|
2018-08-23 |
2021-03-30 |
罗氏创新中心哥本哈根有限公司 |
微小rna-134生物标志物
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
JP2021536239A
(ja)
|
2018-08-28 |
2021-12-27 |
ロシュ イノベーション センター コペンハーゲン エーエス |
スプライス調節化合物を使用したネオアンチゲン操作
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
TW202028465A
(zh)
|
2018-09-28 |
2020-08-01 |
美商阿尼拉製藥公司 |
甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關眼部疾病之使用方法
|
US11123357B2
(en)
|
2018-10-17 |
2021-09-21 |
Lakewood Amedex, Inc. |
Methods and compositions for treating oral mucositis
|
EP3873920A1
(en)
|
2018-11-01 |
2021-09-08 |
F. Hoffmann-La Roche AG |
Antisense oligonucleotides targeting tia1
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
CA3119456A1
(en)
|
2018-11-15 |
2020-05-22 |
Ionis Pharmaceuticals, Inc. |
Modulators of irf5 expression
|
CN113166185A
(zh)
|
2018-11-22 |
2021-07-23 |
罗氏创新中心哥本哈根有限公司 |
作为立体限定的寡核苷酸合成中的活化剂的吡啶鎓盐
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
AU2019396450A1
(en)
|
2018-12-11 |
2021-06-24 |
University Of Rochester |
Methods of treating schizophrenia and other neuropsychiatric disorders
|
WO2020136125A2
(en)
|
2018-12-21 |
2020-07-02 |
Boehringer Ingelheim International Gmbh |
Antisense oligonucleotides targeting card9
|
EP3914232A1
(en)
|
2019-01-25 |
2021-12-01 |
F. Hoffmann-La Roche AG |
Lipid vesicle for oral drug delivery
|
AU2020216444A1
(en)
|
2019-01-31 |
2021-07-29 |
Ionis Pharmaceuticals, Inc. |
Modulators of YAP1 expression
|
US20230057355A1
(en)
|
2019-02-13 |
2023-02-23 |
University Of Rochester |
Gene networks that mediate remyelination of the human brain
|
MX2021009949A
(es)
|
2019-02-20 |
2021-09-21 |
Roche Innovation Ct Copenhagen As |
Fosforamiditas novedosas.
|
JP2022521510A
(ja)
|
2019-02-20 |
2022-04-08 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ホスホノアセテートギャップマー型オリゴヌクレオチド
|
WO2020173845A1
(en)
|
2019-02-26 |
2020-09-03 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide formulation method
|
CA3131700A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
WO2020178258A1
(en)
|
2019-03-05 |
2020-09-10 |
F. Hoffmann-La Roche Ag |
Intracellular targeting of molecules
|
CA3133314A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Extracellular vesicle conjugates and uses thereof
|
EP3967328A4
(en)
|
2019-03-29 |
2022-12-28 |
Sysmex Corporation |
NEW ARTIFICIAL NUCLEIC ACID, PROCESS FOR THEIR PRODUCTION AND ITS USE
|
WO2020206115A2
(en)
|
2019-04-03 |
2020-10-08 |
Bristol-Myers Squibb Company |
Angptl2 antisense oligonucleotides and uses thereof
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
WO2020201339A1
(en)
|
2019-04-04 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating atxn2 expression
|
JP2022529342A
(ja)
|
2019-04-16 |
2022-06-21 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ヌクレオチドp(v)モノマーを調製するための新規の方法
|
CN113767108A
(zh)
|
2019-04-30 |
2021-12-07 |
罗氏创新中心哥本哈根有限公司 |
制备铼螯合mag3寡核苷酸的新方法
|
US20220177880A1
(en)
|
2019-05-03 |
2022-06-09 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
US20220211743A1
(en)
|
2019-05-17 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
EP3980539A1
(en)
|
2019-06-06 |
2022-04-13 |
F. Hoffmann-La Roche AG |
Antisense oligonucleotides targeting atxn3
|
US20220315617A1
(en)
*
|
2019-06-19 |
2022-10-06 |
Yamasa Corporation |
Crosslinked Nucleoside Intermediate Crystal And Method For Producing Same, And Method For Producing Crosslinked Nucleoside Amidite
|
US20220220478A1
(en)
|
2019-06-26 |
2022-07-14 |
Knc Laboratories Co., Ltd. |
Nucleic acid drug suppressing production of myostatin gene mrna
|
US20220251567A1
(en)
|
2019-07-10 |
2022-08-11 |
Inserm (Institut National De La Santè Et De La Recherche Médicale) |
Methods for the treatment of epilepsy
|
BR112021024764A2
(pt)
|
2019-07-12 |
2022-04-19 |
Daiichi Sankyo Co Ltd |
Oligonucleotídeo antissenso capaz de alterar o splicing de pré-mrna de dux4
|
JP2022541502A
(ja)
|
2019-07-18 |
2022-09-26 |
ユニバーシティー オブ ロチェスター |
細胞の細胞型選択的免疫保護
|
EP3956450A4
(en)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATION OF GFAP
|
US20230193274A1
(en)
|
2019-08-14 |
2023-06-22 |
Codiak Biosciences, Inc. |
Extracellular vesicles with stat3-antisense oligonucleotides
|
AU2020327360A1
(en)
|
2019-08-14 |
2022-02-17 |
Lonza Sales Ag |
Extracellular vesicle linked to molecules and uses thereof
|
BR112022002691A2
(pt)
|
2019-08-14 |
2022-08-23 |
Codiak Biosciences Inc |
Construtos de vesícula-aso extracelular visando stat6
|
WO2021030781A1
(en)
|
2019-08-14 |
2021-02-18 |
Codiak Biosciences, Inc. |
Extracellular vesicles with antisense oligonucleotides targeting kras
|
CA3147365A1
(en)
|
2019-08-14 |
2021-02-18 |
Joanne LIM |
Extracellular vesicle-nlrp3 antagonist
|
KR20220070432A
(ko)
|
2019-08-14 |
2022-05-31 |
코디악 바이오사이언시즈, 인크. |
Cebp/베타를 표적으로 하는 세포외 소포-aso 작제물
|
JP2022544587A
(ja)
|
2019-08-15 |
2022-10-19 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
結合修飾オリゴマー化合物及びその使用
|
EP4029520A4
(en)
|
2019-09-10 |
2024-05-29 |
Daiichi Sankyo Co Ltd |
GALNAC-OLIGONUCLEOTIDE CONJUGATE FOR TARGETED DELIVERY TO THE LIVER AND METHOD FOR PRODUCING THE SAME
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
WO2021074657A1
(en)
|
2019-10-17 |
2021-04-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination treatment for cystic fibrosis
|
IL292286A
(en)
|
2019-10-18 |
2022-06-01 |
Daiichi Sankyo Co Ltd |
Production method for bicyclic phosphoramidite
|
CN111109591A
(zh)
|
2019-10-25 |
2020-05-08 |
新疆红旗坡农业发展集团有限公司 |
肠道微生态高效重建型苹果酵素及加工技术
|
JP2023500681A
(ja)
|
2019-11-06 |
2023-01-10 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
肝臓外送達
|
WO2021092145A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
US20230016983A1
(en)
|
2019-11-19 |
2023-01-19 |
lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) |
Antisense oligonucleotides and thier use for the treatment of cancer
|
CN114901821A
(zh)
|
2019-12-19 |
2022-08-12 |
豪夫迈·罗氏有限公司 |
Sept9抑制剂用于治疗乙型肝炎病毒感染的用途
|
EP4077671A1
(en)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Use of saraf inhibitors for treating hepatitis b virus infection
|
CN114829599A
(zh)
|
2019-12-19 |
2022-07-29 |
豪夫迈·罗氏有限公司 |
Scamp3抑制剂用于治疗乙型肝炎病毒感染的用途
|
WO2021122921A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of cops3 inhibitors for treating hepatitis b virus infection
|
WO2021122910A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of sbds inhibitors for treating hepatitis b virus infection
|
EP4077672A1
(en)
|
2019-12-20 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Enhanced oligonucleotides for inhibiting scn9a expression
|
CA3163646A1
(en)
|
2019-12-24 |
2021-07-01 |
F. Hoffman-La Roche Ag |
Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
|
CA3163490A1
(en)
|
2019-12-24 |
2021-07-01 |
F. Hoffman-La Roche Ag |
Pharmaceutical combination of a therapeutic oligonucleotide targeting hbv and a tlr7 agonist for treatment of hbv
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
CN115176010A
(zh)
|
2020-02-28 |
2022-10-11 |
豪夫迈·罗氏有限公司 |
用于调节cd73外显子7剪接的寡核苷酸
|
WO2021182517A1
(ja)
|
2020-03-11 |
2021-09-16 |
隆光 矢野 |
-1フレームシフトを誘導するための1本鎖核酸分子及び組成物
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
US20240092821A1
(en)
|
2020-03-31 |
2024-03-21 |
Janssen Biopharma, Inc. |
Synthesis of oligonucleotides and related compounds
|
IL298063A
(en)
|
2020-05-11 |
2023-01-01 |
Stoke Therapeutics Inc |
opa1 antisense oligomers for the treatment of conditions and diseases
|
CN115551519A
(zh)
|
2020-05-11 |
2022-12-30 |
基因泰克公司 |
用于治疗神经系统疾病的补体组分c1s抑制剂以及相关的组合物、系统和使用它们的方法
|
CN115605592A
(zh)
|
2020-05-11 |
2023-01-13 |
基因泰克公司(Us) |
用于治疗神经系统疾病的补体组分c1r抑制剂以及相关的组合物、系统和使用它们的方法
|
JP2023525770A
(ja)
|
2020-05-11 |
2023-06-19 |
ジェネンテック, インコーポレイテッド |
神経学的疾患を処置するための補体c4阻害剤および関連する組成物、ならびにそれを使用するシステムおよび方法
|
JP2023526267A
(ja)
|
2020-05-13 |
2023-06-21 |
エフ. ホフマン-ラ ロシュ アーゲー |
プログラニュリン標的オリゴヌクレオチドアゴニスト
|
JP2023526096A
(ja)
|
2020-05-22 |
2023-06-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
Card9のスプライス調節のためのオリゴヌクレオチド
|
US20230212572A1
(en)
|
2020-06-09 |
2023-07-06 |
Roche Innovation Center Copenhagen A/S |
Guanosine Analogues for Use in Therapeutics Polynucleotides
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
IL299771A
(en)
|
2020-07-10 |
2023-03-01 |
Inst Nat Sante Rech Med |
Methods and compounds for the treatment of epilepsy
|
EP4185696A1
(en)
|
2020-07-23 |
2023-05-31 |
F. Hoffmann-La Roche AG |
Oligonucleotides targeting rna binding protein sites
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
WO2022024833A1
(ja)
|
2020-07-28 |
2022-02-03 |
神戸天然物化学株式会社 |
アンギオテンシン変換酵素2遺伝子のエクソンのスキッピングを誘導するアンチセンス核酸
|
JP2023538630A
(ja)
|
2020-08-21 |
2023-09-08 |
エフ. ホフマン-ラ ロシュ アーゲー |
B型肝炎ウイルス感染症を処置するためのa1cf阻害剤の使用
|
WO2022043531A1
(en)
*
|
2020-08-28 |
2022-03-03 |
Janssen Sciences Ireland Unlimited Company |
7'-substituted 2'-o-4'-c-ethylene-bridged nucleic acid (ena) monomers and uses thereof
|
CN116322706A
(zh)
|
2020-09-25 |
2023-06-23 |
株式会社理真思 |
新人工核酸、其制造方法和用途
|
US20230364127A1
(en)
|
2020-10-06 |
2023-11-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
TW202237843A
(zh)
|
2020-12-03 |
2022-10-01 |
瑞士商赫孚孟拉羅股份公司 |
靶向atxn3之反義寡核苷酸
|
AR124229A1
(es)
|
2020-12-03 |
2023-03-01 |
Hoffmann La Roche |
Oligonucleótidos antisentido que actúan sobre atxn3
|
CN116568696A
(zh)
|
2020-12-08 |
2023-08-08 |
豪夫迈·罗氏有限公司 |
二硫代磷酸酯寡核苷酸的新颖合成
|
CN116583603A
(zh)
|
2020-12-18 |
2023-08-11 |
豪夫迈·罗氏有限公司 |
靶向颗粒蛋白前体的反义寡核苷酸
|
EP4267734A1
(en)
|
2020-12-22 |
2023-11-01 |
F. Hoffmann-La Roche AG |
Oligonucleotides targeting xbp1
|
AU2021414227A1
(en)
*
|
2020-12-31 |
2023-07-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
WO2022147223A2
(en)
|
2020-12-31 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
AU2021411579A1
(en)
|
2020-12-31 |
2023-07-13 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
JP2024512236A
(ja)
|
2021-02-17 |
2024-03-19 |
ロンザ セールス アーゲー |
細胞外ベシクル-nlrp3アンタゴニスト
|
CN117377499A
(zh)
|
2021-02-17 |
2024-01-09 |
隆萨销售股份有限公司 |
经由优化的接头和锚定部分与生物活性分子连接的细胞外囊泡
|
CN116981772A
(zh)
|
2021-02-26 |
2023-10-31 |
神户天然物化学株式会社 |
表达肌抑素的剪接变体的核酸药物
|
KR20240009393A
(ko)
|
2021-03-31 |
2024-01-22 |
엔트라다 테라퓨틱스, 인크. |
사이클릭 세포 침투 펩티드
|
JP2024513841A
(ja)
|
2021-04-01 |
2024-03-27 |
ロンザ セールス アーゲー |
細胞外小胞組成物
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
JP2024518068A
(ja)
|
2021-05-10 |
2024-04-24 |
エントラーダ セラピューティクス,インコーポレイティド |
細胞内治療のための組成物及び方法
|
EP4337261A2
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating mrna splicing
|
BR112023025676A2
(pt)
|
2021-06-08 |
2024-02-27 |
Hoffmann La Roche |
Agonistas de oligonucleotídeos de progranulina
|
WO2022271818A1
(en)
|
2021-06-23 |
2022-12-29 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
US11633498B2
(en)
|
2021-07-09 |
2023-04-25 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
AU2022314619A1
(en)
|
2021-07-21 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Metabolic disorder-associated target gene irna compositions and methods of use thereof
|
CA3229305A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
WO2023026994A1
(ja)
|
2021-08-21 |
2023-03-02 |
武田薬品工業株式会社 |
ヒトトランスフェリンレセプター結合ペプチド-薬物コンジュゲート
|
AU2022339769A1
(en)
|
2021-09-01 |
2024-03-28 |
Entrada Therapeutics, Inc. |
Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
|
AR127158A1
(es)
|
2021-09-29 |
2023-12-27 |
Hoffmann La Roche |
Oligonucléotido antisentido para la edición de arn asociado a enfermedades de poliglutamina
|
IL311864A
(en)
|
2021-10-15 |
2024-06-01 |
Alnylam Pharmaceuticals Inc |
IRNA compositions for extrahepatic administration and methods of using them
|
WO2023078883A1
(en)
|
2021-11-03 |
2023-05-11 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating apolipoprotein e4 expression
|
CA3234478A1
(en)
|
2021-11-11 |
2023-05-19 |
Souphalone LUANGSAY |
Pharmaceutical combinations for treatment of hbv
|
WO2023104693A1
(en)
|
2021-12-07 |
2023-06-15 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
WO2023111336A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Oligonucleotide gba agonists
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
WO2023117738A1
(en)
|
2021-12-20 |
2023-06-29 |
F. Hoffmann-La Roche Ag |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2023122762A1
(en)
|
2021-12-22 |
2023-06-29 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023141507A1
(en)
|
2022-01-20 |
2023-07-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
WO2023152369A1
(en)
|
2022-02-14 |
2023-08-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis
|
US20240167040A1
(en)
|
2022-02-21 |
2024-05-23 |
Hoffmann-La Roche Inc. |
Antisense oligonucleotide
|
US11931421B2
(en)
|
2022-04-15 |
2024-03-19 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating myotonic dystrophy
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
WO2023222858A1
(en)
|
2022-05-18 |
2023-11-23 |
F. Hoffmann-La Roche Ag |
Improved oligonucleotides targeting rna binding protein sites
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024017990A1
(en)
|
2022-07-21 |
2024-01-25 |
Institut National de la Santé et de la Recherche Médicale |
Methods and compositions for treating chronic pain disorders
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
EP4332221A1
(en)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2024052403A1
(en)
|
2022-09-06 |
2024-03-14 |
F. Hoffmann-La Roche Ag |
Double-stranded rna molecule for administration to the eye
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024098061A2
(en)
|
2022-11-04 |
2024-05-10 |
Genkardia Inc. |
Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure
|
US20240173426A1
(en)
|
2022-11-14 |
2024-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024119145A1
(en)
|
2022-12-01 |
2024-06-06 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
CN117510564B
(zh)
*
|
2024-01-08 |
2024-03-08 |
苏州诺维康生物科技有限公司 |
一种医药中间体N2-Ac-5'-O-DMT-2'-O-炔丙基鸟苷的合成方法
|