US7119184B2
(en)
*
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
JP4148662B2
(ja)
*
|
2000-08-10 |
2008-09-10 |
第一三共株式会社 |
ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬
|
JP4151751B2
(ja)
*
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
DK1334109T3
(da)
|
2000-10-04 |
2006-10-09 |
Santaris Pharma As |
Forbedret syntese af purin-blokerede nukleinsyre-analoger
|
GB0114719D0
(en)
*
|
2001-06-15 |
2001-08-08 |
Glaxo Group Ltd |
Compound
|
WO2003033696A1
(fr)
*
|
2001-10-18 |
2003-04-24 |
Sankyo Company, Limited |
Compose antisens vegf
|
EP2354148B1
(en)
|
2002-02-13 |
2013-09-04 |
Takeshi Imanishi |
Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
WO2004042029A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
AU2003291753B2
(en)
|
2002-11-05 |
2010-07-08 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
AU2013201786B2
(en)
*
|
2002-11-18 |
2015-04-02 |
Roche Innovation Center Copenhagen A/S |
Amino-LNA, thio-LNA and alpha-L-oxy-LN
|
EP2141233B1
(en)
|
2002-11-18 |
2016-10-19 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
JP5132025B2
(ja)
*
|
2002-11-19 |
2013-01-30 |
第一三共株式会社 |
新規2’,5’−オリゴアデニル酸類縁体
|
TWI347948B
(en)
|
2002-11-19 |
2011-09-01 |
Sankyo Co |
Novel 2',5'-oligoadenylic acid compositions
|
EP2386636B1
(en)
*
|
2002-11-25 |
2016-01-27 |
Masafumi Matsuo |
Ena nucleic acid drugs modifying splicing in mrna precursor
|
US20050089889A1
(en)
|
2003-06-20 |
2005-04-28 |
Ramsing Niels B. |
Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
|
EP2530157B1
(en)
|
2003-07-31 |
2016-09-28 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of miRNAs
|
ATE555118T1
(de)
*
|
2003-08-28 |
2012-05-15 |
Takeshi Imanishi |
Neue synthetische nukleidsäuren vom typ mit quervernetzter n-o-bindung
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US7480382B2
(en)
*
|
2003-09-30 |
2009-01-20 |
Microsoft Corporation |
Image file container
|
GB0324854D0
(en)
*
|
2003-10-24 |
2003-11-26 |
Expresson Biosystems Ltd |
App/ena antisense
|
DE602004015832D1
(de)
*
|
2003-11-07 |
2008-09-25 |
Daiichi Sankyo Co Ltd |
Verfahren zum nachweis von genetischem polymorphismus
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
WO2005116207A1
(ja)
*
|
2004-05-28 |
2005-12-08 |
Sankyo Company, Limited |
テロメラーゼ阻害enaオリゴヌクレオチド
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006059507A1
(ja)
*
|
2004-11-30 |
2006-06-08 |
Sankyo Company, Limited |
11β-HSD1アンチセンス化合物
|
WO2006110314A2
(en)
|
2005-03-25 |
2006-10-19 |
Ambion, Inc. |
Methods and compositions for depleting abundant rna transcripts
|
US20090203893A1
(en)
|
2005-08-29 |
2009-08-13 |
Regulus Therapeutics, Llc |
Antisense compounds having enhanced anti-microrna activity
|
US8883162B2
(en)
*
|
2005-10-19 |
2014-11-11 |
Ibc Pharmaceuticals, Inc. |
Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
|
US20100226884A1
(en)
|
2009-01-20 |
2010-09-09 |
Immunomedics, Inc. |
Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
|
US9862770B2
(en)
|
2005-10-19 |
2018-01-09 |
Ibc Pharmaceuticals, Inc. |
Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
|
ES2548240T3
(es)
|
2005-12-01 |
2015-10-15 |
Pronai Therapeutics, Inc. |
Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas
|
EP1970445B1
(en)
*
|
2005-12-09 |
2012-09-26 |
Riken |
Method for nucleic acid replication and novel artificial base pairs
|
JP5713377B2
(ja)
*
|
2005-12-28 |
2015-05-07 |
ザ スクリプス リサーチ インスティテュート |
薬物標的としての天然アンチセンスおよび非コードrna転写物
|
AU2007211080B9
(en)
|
2006-01-27 |
2012-05-03 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
マイクロrnaの調節に使用するためのオリゴマー化合物及び組成物
|
EP2527442A3
(en)
|
2006-05-05 |
2013-03-06 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
WO2007131237A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of ptp1b
|
ES2389737T3
(es)
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en 5'
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
US9550988B2
(en)
|
2006-10-18 |
2017-01-24 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
TW200838551A
(en)
*
|
2006-11-27 |
2008-10-01 |
Isis Pharmaceuticals Inc |
Methods for treating hypercholesterolemia
|
WO2009045469A2
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
WO2008104978A2
(en)
*
|
2007-02-28 |
2008-09-04 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
AU2008260277C1
(en)
|
2007-05-30 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
US8278426B2
(en)
|
2007-06-08 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
WO2009002944A1
(en)
*
|
2007-06-22 |
2008-12-31 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
DK2176280T4
(en)
|
2007-07-05 |
2015-07-20 |
Isis Pharmaceuticals Inc |
6-Disubstituerede bicykliske nukleinsyreanaloge
|
RU2487716C2
(ru)
*
|
2007-10-03 |
2013-07-20 |
Кварк Фармасьютикалс, Инк. |
Новые структуры малых интерферирующих рнк (sirna)
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
WO2009074990A2
(en)
*
|
2007-12-12 |
2009-06-18 |
Quark Pharmaceuticals, Inc. |
Rtp801l sirna compounds and methods of use thereof
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
EP2242854A4
(en)
*
|
2008-01-15 |
2012-08-15 |
Quark Pharmaceuticals Inc |
COMPOUNDS AND USES THEREOF
|
US8530640B2
(en)
|
2008-02-07 |
2013-09-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
JP5697993B2
(ja)
|
2008-02-11 |
2015-04-08 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
修飾RNAiポリヌクレオチドおよびその使用
|
US20110028531A1
(en)
*
|
2008-03-20 |
2011-02-03 |
Elena Feinstein |
Novel sirna compounds for inhibiting rtp801
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
EP2285385A4
(en)
*
|
2008-04-15 |
2013-01-16 |
Quark Pharmaceuticals Inc |
COMPOUNDS BASED ON RNSI TO INHIBIT NRF2
|
WO2009149182A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
EP2293800B1
(en)
|
2008-06-06 |
2016-10-05 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
CA2732343C
(en)
|
2008-07-29 |
2017-05-09 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
KR101762734B1
(ko)
*
|
2008-08-25 |
2017-07-28 |
엑스칼리아드 파마슈티컬즈, 인코포레이티드 |
결합 조직 성장 인자에 대한 안티센스 올리고뉴클레오타이드 및 그의 용도
|
US8664189B2
(en)
|
2008-09-22 |
2014-03-04 |
Rxi Pharmaceuticals Corporation |
RNA interference in skin indications
|
US8501805B2
(en)
|
2008-09-24 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-L-bicyclic nucleosides
|
ES2727549T3
(es)
*
|
2008-10-03 |
2019-10-17 |
Curna Inc |
Tratamiento de las enfermedades relacionadas con la apolipoproteína a1 por inhibición del transcrito antisentido natural a la apolipoproteína a1
|
US9074211B2
(en)
|
2008-11-19 |
2015-07-07 |
Rxi Pharmaceuticals Corporation |
Inhibition of MAP4K4 through RNAI
|
MX2011005912A
(es)
*
|
2008-12-04 |
2011-06-17 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con factor de crecimiento endotelial vascular por inhibicion de transcrito antisentido natural para factor de crecimiento endotelial vascular.
|
EP2370579B1
(en)
|
2008-12-04 |
2017-03-29 |
CuRNA, Inc. |
Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
|
RU2746478C2
(ru)
|
2008-12-04 |
2021-04-14 |
КьюРНА, Инк. |
Лечение связанных с геном-супрессором опухолей заболеваний посредством ингибирования природного транскрипта в антисмысловой ориентации относительно этого гена
|
EP2376633A1
(en)
|
2008-12-17 |
2011-10-19 |
AVI BioPharma, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
US20110288155A1
(en)
|
2008-12-18 |
2011-11-24 |
Elena Feinstein |
Sirna compounds and methods of use thereof
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
US9074210B2
(en)
|
2009-02-12 |
2015-07-07 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
ES2627763T3
(es)
|
2009-03-17 |
2017-07-31 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el homólogo tipo delta 1 (dlk1) por inhibición de transcrito antisentido natural a dlk1
|
EP2421972A2
(en)
|
2009-04-24 |
2012-02-29 |
The Board of Regents of The University of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
DE102009019476A1
(de)
*
|
2009-05-04 |
2010-11-11 |
Biametrics Marken Und Rechte Gmbh |
Wiedererkennbarer Träger für optische Meßverfahren
|
US9155754B2
(en)
|
2009-05-06 |
2015-10-13 |
Curna, Inc. |
Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1
|
EP2427552B1
(en)
|
2009-05-06 |
2016-11-16 |
CuRNA, Inc. |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
US9012139B2
(en)
|
2009-05-08 |
2015-04-21 |
Curna, Inc. |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to DMD family
|
US8957037B2
(en)
|
2009-05-18 |
2015-02-17 |
Curna, Inc. |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
US8895527B2
(en)
|
2009-05-22 |
2014-11-25 |
Curna, Inc. |
Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3
|
US8791085B2
(en)
|
2009-05-28 |
2014-07-29 |
Curna, Inc. |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
WO2010144336A2
(en)
|
2009-06-08 |
2010-12-16 |
Quark Pharmaceuticals, Inc. |
Methods for treating chronic kidney disease
|
WO2010148050A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
US8951981B2
(en)
|
2009-06-16 |
2015-02-10 |
Curna, Inc. |
Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
|
WO2010151671A2
(en)
|
2009-06-24 |
2010-12-29 |
Curna, Inc. |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
EP2446037B1
(en)
|
2009-06-26 |
2016-04-20 |
CuRNA, Inc. |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
CN102712925B
(zh)
|
2009-07-24 |
2017-10-27 |
库尔纳公司 |
通过抑制sirtuin(sirt)的天然反义转录物来治疗sirtuin(sirt)相关性疾病
|
ES2585360T3
(es)
|
2009-08-05 |
2016-10-05 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
CN102625841A
(zh)
|
2009-08-11 |
2012-08-01 |
欧科库尔纳有限责任公司 |
通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
|
EP2982755B1
(en)
|
2009-08-21 |
2020-10-07 |
CuRNA, Inc. |
Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
|
CN102482671B
(zh)
|
2009-08-25 |
2017-12-01 |
库尔纳公司 |
通过抑制‘含有iq模体的gtp酶激活蛋白’(iqgap)的天然反义转录物而治疗iqgap相关疾病
|
ES2664591T3
(es)
|
2009-09-25 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
|
TW201120055A
(en)
|
2009-10-30 |
2011-06-16 |
Daiichi Sankyo Co Ltd |
Modified double strand polynucleotides
|
WO2011053994A1
(en)
|
2009-11-02 |
2011-05-05 |
Alnylam Pharmaceuticals, Inc. |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
EP3434773A3
(en)
|
2009-12-09 |
2019-04-17 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
EP2510098B1
(en)
|
2009-12-09 |
2015-02-11 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for treating diseases, disorders or injury of the cns
|
CN102712927B
(zh)
|
2009-12-16 |
2017-12-01 |
库尔纳公司 |
通过抑制膜结合转录因子肽酶,位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
|
RU2609631C2
(ru)
|
2009-12-23 |
2017-02-02 |
Курна, Инк. |
Лечение заболеваний, связанных с фактором роста гепатоцитов (фрг), посредством ингибирования природного антисмыслового транскрипта к фрг
|
RU2619185C2
(ru)
|
2009-12-23 |
2017-05-12 |
Курна, Инк. |
Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2
|
ES2585829T3
(es)
|
2009-12-29 |
2016-10-10 |
Curna, Inc. |
Tratamiento de las enfermedades relacionadas con la proteína tumoral 63 (p63) por inhibición de transcripción antisentido natural a p63
|
EP2519633B1
(en)
|
2009-12-29 |
2017-10-25 |
CuRNA, Inc. |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
EP2519632B1
(en)
|
2009-12-31 |
2018-04-11 |
CuRNA, Inc. |
Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
|
DK2521784T3
(en)
|
2010-01-04 |
2018-03-12 |
Curna Inc |
TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
|
JP5963680B2
(ja)
|
2010-01-06 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011085347A2
(en)
|
2010-01-11 |
2011-07-14 |
Opko Curna, Llc |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
CA2786568A1
(en)
|
2010-01-25 |
2011-07-28 |
Curna, Inc. |
Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
|
US9574191B2
(en)
|
2010-02-03 |
2017-02-21 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
EP2539452B1
(en)
|
2010-02-22 |
2016-07-27 |
CuRNA, Inc. |
Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
|
EP2545941A4
(en)
|
2010-03-12 |
2013-10-23 |
Daiichi Sankyo Co Ltd |
METHOD FOR THE PROLIFERATION OF CARDIOMYOCYTES USING A MICRO-RNA
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
CN103108642B
(zh)
|
2010-03-24 |
2015-09-23 |
雷克西制药公司 |
皮肤与纤维化症候中的rna干扰
|
EP2550000A4
(en)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
|
CN103200945B
(zh)
|
2010-03-24 |
2016-07-06 |
雷克西制药公司 |
眼部症候中的rna干扰
|
WO2011123745A2
(en)
|
2010-04-02 |
2011-10-06 |
Opko Curna Llc |
Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
|
US9044494B2
(en)
|
2010-04-09 |
2015-06-02 |
Curna, Inc. |
Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
RU2693462C2
(ru)
|
2010-05-03 |
2019-07-03 |
Курна, Инк. |
Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt)
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
JP5917497B2
(ja)
|
2010-05-26 |
2016-05-18 |
カッパーアールエヌエー,インコーポレイテッド |
メチオニンスルホキシドレダクターゼa(msra)に対する天然アンチセンス転写物の阻害によるmsra関連疾患の治療
|
CN107412251A
(zh)
|
2010-05-26 |
2017-12-01 |
库尔纳公司 |
通过抑制无调同源物1(atoh1)的天然反义转录物而治疗atoh1相关疾病
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
JP6023705B2
(ja)
|
2010-06-23 |
2016-11-09 |
カッパーアールエヌエー,インコーポレイテッド |
ナトリウムチャネル、電位依存性、αサブユニット(SCNA)に対する天然アンチセンス転写物の阻害によるSCNA関連疾患の治療
|
WO2012009402A2
(en)
|
2010-07-14 |
2012-01-19 |
Opko Curna Llc |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
EP2412724A1
(en)
|
2010-07-29 |
2012-02-01 |
Centre National de la Recherche Scientifique (C.N.R.S) |
Regulation of Glypican 4 activity to modulate the fate of stem cells and uses thereof
|
KR101886457B1
(ko)
|
2010-10-06 |
2018-08-07 |
큐알엔에이, 인크. |
시알리다아제 4 (neu4)에 대한 자연 안티센스 전사체의 저해에 의한 neu4 관련된 질환의 치료
|
CA2815212A1
(en)
|
2010-10-22 |
2012-04-26 |
Curna, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
EP2643463B1
(en)
|
2010-11-23 |
2017-09-27 |
CuRNA, Inc. |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
TW201307376A
(zh)
|
2010-12-02 |
2013-02-16 |
Daiichi Sankyo Co Ltd |
經修飾之單股多核苷酸
|
WO2012109395A1
(en)
|
2011-02-08 |
2012-08-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
AU2012223365B2
(en)
|
2011-03-03 |
2016-11-10 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating lung disease and injury
|
CA2828544A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
JP6188686B2
(ja)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
フラタキシン(fxn)への天然アンチセンス転写物の阻害によるfxn関連疾患の治療
|
CN103635575B
(zh)
*
|
2011-06-15 |
2019-03-01 |
盖立复治疗公司 |
用于测定人免疫缺陷病毒(hiv)的方法、组合物和试剂盒
|
EP2742056B2
(en)
|
2011-08-11 |
2020-06-10 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
MX365525B
(es)
|
2011-09-06 |
2019-06-06 |
Curna Inc |
Compuestos que regulan la expresión de subunidades alfa de canales de sodio regulados por voltaje en enfermedades relacionadas con epilepsia mioclónica severa de la infancia.
|
CA2848753C
(en)
|
2011-09-14 |
2022-07-26 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
US9422560B2
(en)
|
2011-11-03 |
2016-08-23 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for neuroprotection
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
WO2013138374A2
(en)
|
2012-03-15 |
2013-09-19 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
EP2831232A4
(en)
|
2012-03-30 |
2015-11-04 |
Univ Washington |
METHODS OF MODULATING THE EXPRESSION OF TAU TO REDUCE THE STROKE AND MODIFY A NEURODEGENERATIVE SYMPTOM
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2013154798A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
EP2850189B8
(en)
|
2012-05-16 |
2019-01-23 |
Translate Bio MA, Inc. |
Compositions and methods for modulating gene expression
|
CA2873794A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating smn gene family expression
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
US20150152410A1
(en)
|
2012-05-16 |
2015-06-04 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating mecp2 expression
|
JP2013256452A
(ja)
*
|
2012-06-11 |
2013-12-26 |
Kawaken Fine Chem Co Ltd |
メラニン産生抑制剤とその組成物
|
EP2862868B1
(en)
*
|
2012-06-18 |
2020-04-08 |
Daiichi Sankyo Company, Limited |
Intermediate for production of nucleoside analogue, and method for producing same
|
US9993522B2
(en)
|
2012-09-18 |
2018-06-12 |
Uti Limited Partnership |
Treatment of pain by inhibition of USP5 de-ubiquitinase
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014071406A1
(en)
|
2012-11-05 |
2014-05-08 |
Pronai Therapeutics, Inc. |
Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression
|
US10398661B2
(en)
|
2013-02-28 |
2019-09-03 |
The Board Of Regents Of The University Of Texas System |
Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers
|
WO2014143158A1
(en)
|
2013-03-13 |
2014-09-18 |
The Broad Institute, Inc. |
Compositions and methods for labeling of agents
|
MX2015012621A
(es)
|
2013-03-14 |
2016-05-31 |
Ionis Pharmaceuticals Inc |
Composiciones y metodos para modular la expresion de tau.
|
US9273349B2
(en)
|
2013-03-14 |
2016-03-01 |
Affymetrix, Inc. |
Detection of nucleic acids
|
US9822418B2
(en)
|
2013-04-22 |
2017-11-21 |
Icahn School Of Medicine At Mount Sinai |
Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis
|
KR20200090966A
(ko)
|
2013-05-01 |
2020-07-29 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포지질단백질 c-iii 발현을 조절하는 조성물 및 방법
|
TW202246503A
(zh)
|
2013-07-19 |
2022-12-01 |
美商百健Ma公司 |
用於調節τ蛋白表現之組合物
|
EP3052632A4
(en)
|
2013-10-04 |
2017-03-29 |
Rana Therapeutics, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
WO2015075166A1
(en)
|
2013-11-22 |
2015-05-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of a bacterial infection
|
RU2744194C2
(ru)
|
2013-12-02 |
2021-03-03 |
Фио Фармасьютикалс Корп |
Иммунотерапия рака
|
US9765332B2
(en)
|
2014-01-29 |
2017-09-19 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
|
PT3757214T
(pt)
|
2014-04-01 |
2022-08-26 |
Biogen Ma Inc |
Composições para modulação da expressão de sod-1
|
EP3137119B1
(en)
|
2014-04-28 |
2020-07-01 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using a nucleic acid targeting mdm2
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
HUE046272T2
(hu)
|
2014-05-01 |
2020-02-28 |
Ionis Pharmaceuticals Inc |
Készítmények és eljárások a komplement B-faktor expressziójának modulálására
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
JP6562517B2
(ja)
*
|
2014-07-31 |
2019-08-21 |
国立大学法人大阪大学 |
架橋型ヌクレオシドおよびヌクレオチド
|
IL234246A0
(en)
|
2014-08-21 |
2014-11-30 |
Omrix Biopharmaceuticals Ltd |
Stabilized thrombin
|
KR102689262B1
(ko)
|
2014-09-05 |
2024-07-30 |
피오 파마슈티칼스 코프. |
Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
|
EP3201339A4
(en)
|
2014-10-03 |
2018-09-19 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
US20170369872A1
(en)
|
2014-12-18 |
2017-12-28 |
Alnylam Pharmaceuticals, Inc. |
Reversir tm compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
WO2017007813A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
EP3324980B1
(en)
|
2015-07-17 |
2021-11-10 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
JP6835826B2
(ja)
|
2015-08-24 |
2021-02-24 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Lna−gプロセス
|
US10196639B2
(en)
|
2015-10-09 |
2019-02-05 |
University Of Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
CN109563509B
(zh)
|
2015-10-19 |
2022-08-09 |
菲奥医药公司 |
靶向长非编码rna的减小尺寸的自递送核酸化合物
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
EP3371211A4
(en)
|
2015-11-04 |
2019-08-21 |
Icahn School of Medicine at Mount Sinai |
METHOD FOR THE TREATMENT OF TUMORS AND CANCER AND IDENTIFICATION OF CANDIDATE PATIENTS FOR SUCH TREATMENT
|
RS61529B9
(sr)
|
2015-11-12 |
2024-04-30 |
Hoffmann La Roche |
Oligonukleotidi za indukovanje ekspresije paternalnog ube3a
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
WO2017106377A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
JOP20200228A1
(ar)
|
2015-12-21 |
2017-06-16 |
Novartis Ag |
تركيبات وطرق لخفض تعبير البروتين tau
|
RS61528B1
(sr)
|
2016-03-14 |
2021-04-29 |
Hoffmann La Roche |
Oligonukleotidi za smanjenje ekspresije pd-l1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
CN109153697A
(zh)
|
2016-04-14 |
2019-01-04 |
豪夫迈·罗氏有限公司 |
三苯甲基-单-GalNAc化合物及其用途
|
WO2017189730A1
(en)
|
2016-04-26 |
2017-11-02 |
Icahn School Of Medicine At Mount Sinai |
Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
|
CA3023514A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
CA3026855A1
(en)
|
2016-07-01 |
2018-01-04 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
EP3481430A4
(en)
|
2016-07-11 |
2020-04-01 |
Translate Bio Ma, Inc. |
NUCLEIC ACID CONJUGATES AND USES THEREOF
|
US10793859B2
(en)
|
2016-09-14 |
2020-10-06 |
Janssen Biopharma, Inc. |
Modified oligonucleotides and methods of use
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
US11730823B2
(en)
|
2016-10-03 |
2023-08-22 |
President And Fellows Of Harvard College |
Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
|
WO2018087200A1
(en)
|
2016-11-11 |
2018-05-17 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
JP7072748B2
(ja)
|
2016-12-28 |
2022-05-23 |
国立大学法人神戸大学 |
アルポート症候群治療薬
|
UY37565A
(es)
|
2017-01-10 |
2018-07-31 |
Arrowhead Pharmaceuticals Inc |
Agentes de iarn alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y métodos de uso
|
WO2018130584A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
US20190338286A1
(en)
|
2017-01-13 |
2019-11-07 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
WO2018130585A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
US20190367920A1
(en)
|
2017-01-13 |
2019-12-05 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb1 expression
|
WO2018130581A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
US11377468B2
(en)
|
2017-03-10 |
2022-07-05 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
JP7048574B2
(ja)
|
2017-03-10 |
2022-04-05 |
国立研究開発法人国立成育医療研究センター |
アンチセンスオリゴヌクレオチドおよび糖原病Ia型予防または治療用組成物
|
US12030908B2
(en)
|
2017-03-10 |
2024-07-09 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
US11795192B2
(en)
|
2017-03-10 |
2023-10-24 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
KR102684529B1
(ko)
|
2017-03-10 |
2024-07-12 |
레이크우드 아메덱스, 인크. |
항미생물 화합물, 조성물, 및 그의 용도
|
JP7306653B2
(ja)
|
2017-03-17 |
2023-07-11 |
国立大学法人千葉大学 |
構造強化されたS-TuDを用いた新規がん治療法
|
US11179411B2
(en)
|
2017-05-18 |
2021-11-23 |
Kyoto University |
Composition for prevention or treatment of spinocerebellar ataxia type 36
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
WO2019009299A1
(ja)
|
2017-07-05 |
2019-01-10 |
国立大学法人大阪大学 |
α-シヌクレイン発現抑制するENAアンチセンスオリゴヌクレオチド
|
WO2019013141A1
(ja)
|
2017-07-10 |
2019-01-17 |
国立大学法人大阪大学 |
Tdp-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
EP3668984A4
(en)
|
2017-08-18 |
2021-09-08 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF THE NOTCH SIGNALING PATH FOR THE TREATMENT OF RESPIRATORY DISORDERS
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
PL3673080T3
(pl)
|
2017-08-25 |
2024-03-11 |
Stoke Therapeutics, Inc. |
Oligomery antysensowne do leczenia stanów i chorób
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
JP2020533009A
(ja)
|
2017-09-14 |
2020-11-19 |
ヤンセン バイオファーマ インク. |
GalNAc誘導体
|
JP2021502059A
(ja)
|
2017-10-13 |
2021-01-28 |
ロシュ イノベーション センター コペンハーゲン エーエス |
部分的に立体定義されたオリゴヌクレオチドのサブライブラリーを使用することによる、アンチセンスオリゴヌクレオチドの、改良された立体定義されたホスホロチオエートオリゴヌクレオチド変異体を同定するための方法
|
TWI762732B
(zh)
|
2017-10-16 |
2022-05-01 |
瑞士商赫孚孟拉羅股份公司 |
用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子
|
WO2019076919A1
(en)
|
2017-10-17 |
2019-04-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
COMBINED TREATMENT OF CYSTIC FIBROSIS
|
WO2019111791A1
(ja)
*
|
2017-12-07 |
2019-06-13 |
第一三共株式会社 |
ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド
|
EP3724333A2
(en)
|
2017-12-11 |
2020-10-21 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating fndc3b expression
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
JP2021507253A
(ja)
|
2017-12-21 |
2021-02-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Htra1 rnaアンタゴニストについてのコンパニオン診断
|
WO2019122277A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Novel thiophosphoramidites
|
EP3728591A1
(en)
|
2017-12-22 |
2020-10-28 |
Roche Innovation Center Copenhagen A/S |
Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
CN111757936A
(zh)
|
2017-12-22 |
2020-10-09 |
罗氏创新中心哥本哈根有限公司 |
包含二硫代磷酸酯核苷间连接的寡核苷酸
|
EP3737758A1
(en)
|
2018-01-10 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating pias4 expression
|
EP3737761A1
(en)
|
2018-01-12 |
2020-11-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
US20220119811A1
(en)
|
2018-01-12 |
2022-04-21 |
Roche Innovation Center Copenhagen A/S |
Alpha-synuclein antisense oligonucleotides and uses thereof
|
CA3088112A1
(en)
|
2018-01-12 |
2019-07-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
EP3737760A1
(en)
|
2018-01-12 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating gsk3b expression
|
CN111615558A
(zh)
|
2018-01-17 |
2020-09-01 |
罗氏创新中心哥本哈根有限公司 |
用于调节erc1表达的寡核苷酸
|
CN111655851A
(zh)
|
2018-01-18 |
2020-09-11 |
哥本哈根罗氏创新中心 |
靶向srebp1的反义寡核苷酸
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
MA51795A
(fr)
|
2018-02-09 |
2020-12-16 |
Hoffmann La Roche |
Oligonucléotides pour moduler l'expression de tmem106b
|
BR112020016347A2
(pt)
|
2018-02-21 |
2021-01-12 |
Bristol-Myers Squibb Company |
Oligonucleotídeos antisense de camk2d e seus usos
|
JP6884268B2
(ja)
|
2018-03-09 |
2021-06-09 |
第一三共株式会社 |
糖原病Ia型治療薬
|
AU2019233612A1
(en)
|
2018-03-13 |
2020-09-10 |
Janssen Pharmaceutica Nv |
Modified oligonucleotides for use in treatment of tauopathies
|
MA52661A
(fr)
|
2018-04-05 |
2021-02-17 |
Centre Leon Berard |
Utilisation d'inhibiteurs de fubp1 dans le traitement d'une infection par le virus de l'hépatite b
|
BR112020022512A2
(pt)
|
2018-05-04 |
2021-05-04 |
Stoke Therapeutics, Inc. |
métodos e composições para tratamento de doença de armazenamento de éster de colesteril
|
WO2019217459A1
(en)
|
2018-05-07 |
2019-11-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
US20210071247A1
(en)
|
2018-05-07 |
2021-03-11 |
Roche Innovation Center Copenhagen A/S |
Massively parallel discovery methods for oligonucleotide therapeutics
|
WO2019215175A1
(en)
|
2018-05-08 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
US20210220387A1
(en)
|
2018-05-18 |
2021-07-22 |
Hoffmann-La Roche, Inc. |
Pharmaceutical compositions for treatment of microrna related diseases
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
CN112912500A
(zh)
|
2018-06-05 |
2021-06-04 |
豪夫迈·罗氏有限公司 |
用于调节atxn2表达的寡核苷酸
|
KR20210019498A
(ko)
|
2018-06-13 |
2021-02-22 |
다이이찌 산쿄 가부시키가이샤 |
심근 장해 치료약
|
CA3103663A1
(en)
|
2018-06-18 |
2019-12-26 |
University Of Rochester |
Inhibition of re1-silencing transcription factor in the treatment of schizophrenia and other neuropsychiatric disorders
|
CN112654366A
(zh)
|
2018-06-21 |
2021-04-13 |
罗切斯特大学 |
治疗或抑制亨廷顿病发作的方法
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
CA3103054A1
(en)
|
2018-07-03 |
2020-01-09 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating tau expression
|
EP3819378A4
(en)
|
2018-07-04 |
2022-09-14 |
Aichi Medical University |
OLIGONUCLEOTIDES FOR CONTROL OF TAU SPLICING AND THEIR USES
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011902A1
(en)
|
2018-07-13 |
2020-01-16 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating rtel1 expression
|
CN112236439A
(zh)
|
2018-07-31 |
2021-01-15 |
罗氏创新中心哥本哈根有限公司 |
包含三硫代磷酸酯核苷间键的寡核苷酸
|
EP3830102B1
(en)
|
2018-07-31 |
2022-06-08 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
US11911484B2
(en)
|
2018-08-02 |
2024-02-27 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
US12097263B2
(en)
|
2018-08-02 |
2024-09-24 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
JP7499754B2
(ja)
|
2018-08-23 |
2024-06-14 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブ |
Microrna-134バイオマーカー
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
US20220160870A1
(en)
|
2018-08-28 |
2022-05-26 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
JP7470107B2
(ja)
|
2018-09-28 |
2024-04-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
トランスサイレチン(TTR)iRNA組成物及びTTR関連眼疾患を治療又は予防するためのその使用方法
|
EP3866810A4
(en)
|
2018-10-17 |
2022-07-27 |
Lakewood Amedex, Inc. |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF ORAL MUCOSITIS
|
CN112969709A
(zh)
|
2018-11-01 |
2021-06-15 |
豪夫迈·罗氏有限公司 |
靶向tia1的反义寡核苷酸
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
CR20210311A
(es)
|
2018-11-15 |
2021-07-22 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresión de irf5
|
EP3883941A1
(en)
|
2018-11-22 |
2021-09-29 |
Roche Innovation Center Copenhagen A/S |
Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
AU2019396450A1
(en)
|
2018-12-11 |
2021-06-24 |
University Of Rochester |
Methods of treating schizophrenia and other neuropsychiatric disorders
|
EP3898975A2
(en)
|
2018-12-21 |
2021-10-27 |
Boehringer Ingelheim International GmbH |
Antisense oligonucleotides targeting card9
|
CN113365607A
(zh)
|
2019-01-25 |
2021-09-07 |
豪夫迈·罗氏有限公司 |
用于口服药物递送的脂质囊泡
|
US11214803B2
(en)
|
2019-01-31 |
2022-01-04 |
Ionis Pharmaceuticals, Inc. |
Modulators of YAP1 expression
|
US20230057355A1
(en)
|
2019-02-13 |
2023-02-23 |
University Of Rochester |
Gene networks that mediate remyelination of the human brain
|
EP3927716A1
(en)
|
2019-02-20 |
2021-12-29 |
Roche Innovation Center Copenhagen A/S |
Novel phosphoramidites
|
JP2022521510A
(ja)
|
2019-02-20 |
2022-04-08 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ホスホノアセテートギャップマー型オリゴヌクレオチド
|
JP7503072B2
(ja)
|
2019-02-26 |
2024-06-19 |
ロシュ イノベーション センター コペンハーゲン エーエス |
オリゴヌクレオチドの製剤化方法
|
MX2021010152A
(es)
|
2019-02-27 |
2021-09-14 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresion de malat1.
|
WO2020178258A1
(en)
|
2019-03-05 |
2020-09-10 |
F. Hoffmann-La Roche Ag |
Intracellular targeting of molecules
|
SG11202109587TA
(en)
|
2019-03-21 |
2021-10-28 |
Codiak Biosciences Inc |
Extracellular vesicle conjugates and uses thereof
|
JP7413362B2
(ja)
|
2019-03-29 |
2024-01-15 |
シスメックス株式会社 |
新規人工核酸、その製造方法及び用途
|
MX2021012098A
(es)
|
2019-04-03 |
2021-11-03 |
Bristol Myers Squibb Co |
Oligonucleotidos antisentido del transcrito tipo 2 de angiopoyetina (angptl2) y sus usos.
|
CN113785060A
(zh)
|
2019-04-04 |
2021-12-10 |
豪夫迈·罗氏有限公司 |
用于调节atxn2表达的寡核苷酸
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
WO2020212301A1
(en)
|
2019-04-16 |
2020-10-22 |
Roche Innovation Center Copenhagen A/S |
Novel process for preparing nucleotide p(v) monomers
|
JP2022530537A
(ja)
|
2019-04-30 |
2022-06-29 |
ロシュ イノベーション センター コペンハーゲン エーエス |
レニウムキレート化mag3オリゴヌクレオチドを調製するための新規の方法
|
JP2022530678A
(ja)
|
2019-05-03 |
2022-06-30 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
短縮センス鎖を有する二本鎖核酸阻害剤分子
|
CA3138915A1
(en)
|
2019-05-17 |
2020-11-26 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
CN113950529A
(zh)
|
2019-06-06 |
2022-01-18 |
豪夫迈·罗氏有限公司 |
靶向atxn3的反义寡核苷酸
|
JPWO2020256084A1
(no)
*
|
2019-06-19 |
2020-12-24 |
|
|
CN114080238A
(zh)
|
2019-06-26 |
2022-02-22 |
神户天然物化学株式会社 |
抑制肌肉生长抑制素基因的mRNA的产生的核酸药物
|
EP3997225A1
(en)
|
2019-07-10 |
2022-05-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of epilepsy
|
JPWO2021010301A1
(no)
|
2019-07-12 |
2021-01-21 |
|
|
CN114787358A
(zh)
|
2019-07-18 |
2022-07-22 |
罗切斯特大学 |
细胞的细胞类型选择性免疫保护
|
US11786546B2
(en)
|
2019-07-26 |
2023-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating GFAP
|
CA3147365A1
(en)
|
2019-08-14 |
2021-02-18 |
Joanne LIM |
Extracellular vesicle-nlrp3 antagonist
|
US20230193274A1
(en)
|
2019-08-14 |
2023-06-22 |
Codiak Biosciences, Inc. |
Extracellular vesicles with stat3-antisense oligonucleotides
|
EP4013878A1
(en)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extracellular vesicle-aso constructs targeting cebp/beta
|
US20220354963A1
(en)
|
2019-08-14 |
2022-11-10 |
Codiak Biosciences, Inc. |
Extracellular vesicle linked to molecules and uses thereof
|
MX2022001767A
(es)
|
2019-08-14 |
2022-06-09 |
Codiak Biosciences Inc |
Construcciones de vesículas-oligonucleótidos antisentido (aso) extracelulares que se dirigen a transductor de señal y activador de la transcripción 6 (stat6).
|
EP4013872A1
(en)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extracellular vesicles with antisense oligonucleotides targeting kras
|
KR20220062517A
(ko)
|
2019-08-15 |
2022-05-17 |
아이오니스 파마수티컬즈, 인코포레이티드 |
결합 변형된 올리고머 화합물 및 이의 용도
|
TW202123973A
(zh)
|
2019-09-10 |
2021-07-01 |
日商第一三共股份有限公司 |
用於肝臟遞送之GalNAc-寡核苷酸結合物及製造方法
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
WO2021074657A1
(en)
|
2019-10-17 |
2021-04-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination treatment for cystic fibrosis
|
US20230348522A1
(en)
|
2019-10-18 |
2023-11-02 |
Daiichi Sankyo Company, Limited |
Method for producing bicyclic phosphoramidite
|
CN111109591A
(zh)
|
2019-10-25 |
2020-05-08 |
新疆红旗坡农业发展集团有限公司 |
肠道微生态高效重建型苹果酵素及加工技术
|
CN114945669A
(zh)
|
2019-11-06 |
2022-08-26 |
阿尔尼拉姆医药品有限公司 |
肝外递送
|
EP4055165A1
(en)
|
2019-11-06 |
2022-09-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
WO2021099394A1
(en)
|
2019-11-19 |
2021-05-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Antisense oligonucleotides and their use for the treatment of cancer
|
JP2023506540A
(ja)
|
2019-12-19 |
2023-02-16 |
エフ. ホフマン-ラ ロシュ エージー. |
B型肝炎ウイルス感染を処置するためのscamp3阻害剤の使用
|
WO2021122735A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of sept9 inhibitors for treating hepatitis b virus infection
|
JP2023506547A
(ja)
|
2019-12-19 |
2023-02-16 |
エフ. ホフマン-ラ ロシュ エージー. |
B型肝炎ウイルス感染を処置するためのcops3阻害剤の使用
|
WO2021122993A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of saraf inhibitors for treating hepatitis b virus infection
|
CN114829601A
(zh)
|
2019-12-19 |
2022-07-29 |
豪夫迈·罗氏有限公司 |
Sbds抑制剂用于治疗乙型肝炎病毒感染的用途
|
JP7288052B2
(ja)
|
2019-12-20 |
2023-06-06 |
エフ. ホフマン-ラ ロシュ アーゲー |
Scn9a発現を阻害するための増強されたオリゴヌクレオチド
|
EP4081217A1
(en)
|
2019-12-24 |
2022-11-02 |
F. Hoffmann-La Roche AG |
Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
|
JP2023509870A
(ja)
|
2019-12-24 |
2023-03-10 |
エフ. ホフマン-ラ ロシュ アーゲー |
Hbvの処置のためのhbvを標的とする治療用オリゴヌクレオチドとtlr7アゴニストとの医薬組合せ
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
WO2021170697A1
(en)
|
2020-02-28 |
2021-09-02 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating cd73 exon 7 splicing
|
JP6953053B1
(ja)
|
2020-03-11 |
2021-10-27 |
隆光 矢野 |
−1フレームシフトを誘導するための1本鎖核酸分子及び組成物
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
JP2023520201A
(ja)
|
2020-03-31 |
2023-05-16 |
ヤンセン バイオファーマ インク. |
オリゴヌクレオチド及び関連化合物の合成
|
JP2023525799A
(ja)
|
2020-05-11 |
2023-06-19 |
ストーク セラピューティクス,インク. |
状態及び疾患の治療のためのopa1アンチセンスオリゴマー
|
WO2021231204A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same
|
WO2021231210A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component c1r inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
EP4149486A1
(en)
|
2020-05-11 |
2023-03-22 |
Genentech, Inc. |
Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
US20210388357A1
(en)
|
2020-05-13 |
2021-12-16 |
Hoffmann-La Roche Inc. |
Oligonucleotide agonists targeting progranulin
|
US20230193269A1
(en)
|
2020-05-22 |
2023-06-22 |
Boehringer Ingelheim International Gmbh |
Oligonucleotides for splice modulation of card9
|
US20230212572A1
(en)
|
2020-06-09 |
2023-07-06 |
Roche Innovation Center Copenhagen A/S |
Guanosine Analogues for Use in Therapeutics Polynucleotides
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
CN116113697A
(zh)
|
2020-07-10 |
2023-05-12 |
国家健康与医学研究院 |
用于治疗癫痫的方法和组合物
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
CN116209761A
(zh)
|
2020-07-23 |
2023-06-02 |
豪夫迈·罗氏有限公司 |
靶向rna结合蛋白位点的寡核苷酸
|
CN115916976A
(zh)
|
2020-07-28 |
2023-04-04 |
神户天然物化学株式会社 |
诱导血管紧张素转换酶2基因外显子跳跃的反义核酸
|
EP4200419A2
(en)
|
2020-08-21 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Use of a1cf inhibitors for treating hepatitis b virus infection
|
WO2022043531A1
(en)
*
|
2020-08-28 |
2022-03-03 |
Janssen Sciences Ireland Unlimited Company |
7'-substituted 2'-o-4'-c-ethylene-bridged nucleic acid (ena) monomers and uses thereof
|
EP4219517A4
(en)
|
2020-09-25 |
2024-09-25 |
Riken Genesis Co Ltd |
NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF
|
US20230364127A1
(en)
|
2020-10-06 |
2023-11-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
TW202237843A
(zh)
|
2020-12-03 |
2022-10-01 |
瑞士商赫孚孟拉羅股份公司 |
靶向atxn3之反義寡核苷酸
|
AR124229A1
(es)
|
2020-12-03 |
2023-03-01 |
Hoffmann La Roche |
Oligonucleótidos antisentido que actúan sobre atxn3
|
CN116568696A
(zh)
|
2020-12-08 |
2023-08-08 |
豪夫迈·罗氏有限公司 |
二硫代磷酸酯寡核苷酸的新颖合成
|
WO2022129320A1
(en)
|
2020-12-18 |
2022-06-23 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
JP2024501662A
(ja)
|
2020-12-22 |
2024-01-15 |
エフ. ホフマン-ラ ロシュ アーゲー |
Xbp1を標的とするオリゴヌクレオチド
|
KR20230136130A
(ko)
|
2020-12-31 |
2023-09-26 |
알닐람 파마슈티칼스 인코포레이티드 |
시클릭-디설파이드 개질된 인산염 기반 올리고뉴클레오티드전구약물
|
AU2021414227A1
(en)
*
|
2020-12-31 |
2023-07-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
US20240336914A1
(en)
|
2020-12-31 |
2024-10-10 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
IL305171A
(en)
|
2021-02-17 |
2023-10-01 |
Lonza Sales Ag |
EXTRACELLULAR VESILE-NLRP3 antagonist
|
US20240189430A1
(en)
|
2021-02-17 |
2024-06-13 |
Lonza Sales Ag |
Extracellular vesicle linked to a biologically active molecule via an optimized linker and an anchoring moiety
|
EP4299743A1
(en)
|
2021-02-26 |
2024-01-03 |
KNC Laboratories Co., Ltd. |
Nucleic acid medicine expressing splicing variant of myostatin
|
AU2022249318A1
(en)
|
2021-03-31 |
2023-10-12 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
US20240209368A1
(en)
|
2021-04-01 |
2024-06-27 |
Lonza Sales Ag |
Extracellular vesicle compositions
|
JP2024518476A
(ja)
|
2021-05-10 |
2024-05-01 |
エントラーダ セラピューティクス,インコーポレイティド |
mRNAスプライシングを調節するための組成物及び方法
|
CA3218805A1
(en)
|
2021-05-10 |
2022-11-17 |
Ziqing QIAN |
Compositions and methods for intracellular therapeutics
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
US20220403388A1
(en)
|
2021-06-08 |
2022-12-22 |
Hoffmann-La Roche Inc. |
Oligonucleotide Progranulin Agonists
|
IL309001A
(en)
|
2021-06-23 |
2024-02-01 |
Entrada Therapeutics Inc |
Antisense compounds and methods for targeting CUG repeats
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
US11633498B2
(en)
|
2021-07-09 |
2023-04-25 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
EP4373937A1
(en)
|
2021-07-21 |
2024-05-29 |
Alnylam Pharmaceuticals, Inc. |
Metabolic disorder-associated target gene irna compositions and methods of use thereof
|
WO2023021046A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
JPWO2023026994A1
(no)
|
2021-08-21 |
2023-03-02 |
|
|
CA3229661A1
(en)
|
2021-09-01 |
2023-03-09 |
Xiang Li |
Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
|
AR127158A1
(es)
|
2021-09-29 |
2023-12-27 |
Hoffmann La Roche |
Oligonucléotido antisentido para la edición de arn asociado a enfermedades de poliglutamina
|
EP4416284A1
(en)
|
2021-10-15 |
2024-08-21 |
Alnylam Pharmaceuticals, Inc. |
Extra-hepatic delivery irna compositions and methods of use thereof
|
EP4426833A1
(en)
|
2021-11-03 |
2024-09-11 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating apolipoprotein e4 expression
|
KR20240101580A
(ko)
|
2021-11-11 |
2024-07-02 |
에프. 호프만-라 로슈 아게 |
Hbv 치료를 위한 약학 조합물
|
CN118434858A
(zh)
|
2021-12-07 |
2024-08-02 |
豪夫迈·罗氏有限公司 |
靶向actl6b的反义寡核苷酸
|
CN118489009A
(zh)
|
2021-12-17 |
2024-08-13 |
豪夫迈·罗氏有限公司 |
寡核苷酸gba激动剂
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
CN118434860A
(zh)
|
2021-12-20 |
2024-08-02 |
豪夫迈·罗氏有限公司 |
苏糖核酸反义寡核苷酸及其方法
|
AU2022421244A1
(en)
|
2021-12-22 |
2024-07-11 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023127857A1
(ja)
|
2021-12-27 |
2023-07-06 |
株式会社理研ジェネシス |
新規人工核酸、その製造方法及び用途
|
WO2023141507A1
(en)
|
2022-01-20 |
2023-07-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
WO2023152369A1
(en)
|
2022-02-14 |
2023-08-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis
|
US20240167040A1
(en)
|
2022-02-21 |
2024-05-23 |
Hoffmann-La Roche Inc. |
Antisense oligonucleotide
|
AU2023254846A1
(en)
|
2022-04-15 |
2024-10-10 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating myotonic dystrophy
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
TW202409276A
(zh)
|
2022-05-18 |
2024-03-01 |
瑞士商赫孚孟拉羅股份公司 |
改良之靶向rna結合蛋白位點的寡核苷酸
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024017990A1
(en)
|
2022-07-21 |
2024-01-25 |
Institut National de la Santé et de la Recherche Médicale |
Methods and compositions for treating chronic pain disorders
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
EP4332221A1
(en)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
TW202421206A
(zh)
|
2022-09-06 |
2024-06-01 |
瑞士商赫孚孟拉羅股份公司 |
用於投予至眼睛之雙股rna分子
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
WO2024098061A2
(en)
|
2022-11-04 |
2024-05-10 |
Genkardia Inc. |
Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure
|
WO2024098002A1
(en)
|
2022-11-04 |
2024-05-10 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024119145A1
(en)
|
2022-12-01 |
2024-06-06 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2024126654A1
(en)
|
2022-12-14 |
2024-06-20 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
WO2024146935A1
(en)
|
2023-01-06 |
2024-07-11 |
Institut National de la Santé et de la Recherche Médicale |
Intravenous administration of antisense oligonucleotides for the treatment of pain
|
WO2024160756A1
(en)
|
2023-01-30 |
2024-08-08 |
Vib Vzw |
Suppressors of tauopathies
|
WO2024168010A2
(en)
|
2023-02-09 |
2024-08-15 |
Alnylam Pharmaceuticals, Inc. |
Reversir molecules and methods of use thereof
|
WO2024175588A1
(en)
|
2023-02-21 |
2024-08-29 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
WO2024175586A2
(en)
|
2023-02-21 |
2024-08-29 |
Vib Vzw |
Inhibitors of synaptogyrin-3 expression
|
CN117510564B
(zh)
*
|
2024-01-08 |
2024-03-08 |
苏州诺维康生物科技有限公司 |
一种医药中间体N2-Ac-5'-O-DMT-2'-O-炔丙基鸟苷的合成方法
|