MX2015012621A - Composiciones y metodos para modular la expresion de tau. - Google Patents

Composiciones y metodos para modular la expresion de tau.

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Publication number
MX2015012621A
MX2015012621A MX2015012621A MX2015012621A MX2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A MX 2015012621 A MX2015012621 A MX 2015012621A
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MX
Mexico
Prior art keywords
methods
tau
compositions
animal
disclosed
Prior art date
Application number
MX2015012621A
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English (en)
Inventor
Frank Rigo
C Frank Bennett
Original Assignee
Ionis Pharmaceuticals Inc
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Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2015012621A publication Critical patent/MX2015012621A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/33—Alteration of splicing

Abstract

Se describen métodos para modular empalme de ARNm de Tau en un animal con compuestos antisentido de Tau. También se describen métodos para reducir la expresión de ARNm de Tau y proteína en un animal con compuestos antisentido de Tau. Tales compuestos y métodos son útiles para tratar, prevenir o mejorar enfermedades neurodegenerativas en un individuo en necesidad de lo mismo. Ejemplos de enfermedades neurodegenerativos que pueden ser tratadas, prevenidas y mejoradas con la administración de oligonucleótidos antisentido de Tau incluyen enfermedad de Alzheimer, demencia frontotemporal (FTD), FTDP-17, parálisis supranuclear progresiva, encefalopatía traumática crónica, epilepsia y síndrome de Dravet.
MX2015012621A 2013-03-14 2014-03-14 Composiciones y metodos para modular la expresion de tau. MX2015012621A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US201461943931P 2014-02-24 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

Publications (1)

Publication Number Publication Date
MX2015012621A true MX2015012621A (es) 2016-05-31

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MX2015012621A MX2015012621A (es) 2013-03-14 2014-03-14 Composiciones y metodos para modular la expresion de tau.

Country Status (14)

Country Link
US (3) US9644207B2 (es)
EP (2) EP3766974A1 (es)
JP (2) JP6629716B2 (es)
KR (1) KR20150130430A (es)
CN (2) CN111254145A (es)
AU (1) AU2014236156C1 (es)
BR (1) BR112015022156A2 (es)
CA (1) CA2906119A1 (es)
ES (1) ES2807379T3 (es)
HK (1) HK1218659A1 (es)
IL (1) IL241439B (es)
MX (1) MX2015012621A (es)
RU (1) RU2745324C2 (es)
WO (1) WO2014153236A1 (es)

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