MX371343B - Moduladores del receptor x hepatico (lxr). - Google Patents

Moduladores del receptor x hepatico (lxr).

Info

Publication number
MX371343B
MX371343B MX2016002931A MX2016002931A MX371343B MX 371343 B MX371343 B MX 371343B MX 2016002931 A MX2016002931 A MX 2016002931A MX 2016002931 A MX2016002931 A MX 2016002931A MX 371343 B MX371343 B MX 371343B
Authority
MX
Mexico
Prior art keywords
lxr
modulators
liver
receptor
disorders
Prior art date
Application number
MX2016002931A
Other languages
English (en)
Other versions
MX2016002931A (es
Inventor
Mohan Raju
Original Assignee
Ralexar Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ralexar Therapeutics Inc filed Critical Ralexar Therapeutics Inc
Publication of MX2016002931A publication Critical patent/MX2016002931A/es
Publication of MX371343B publication Critical patent/MX371343B/es

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/10—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring nitrogen atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
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  • Cardiology (AREA)
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  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)

Abstract

La presente describe moduladores de receptor X del hígado (LXR) y métodos para utilizar los moduladores de LXR en el tratamiento de enfermedades, trastornos o condiciones asociadas con LXR. También se describen composiciones farmacéuticas que contienen dichos compuestos.
MX2016002931A 2013-09-04 2014-09-04 Moduladores del receptor x hepatico (lxr). MX371343B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873755P 2013-09-04 2013-09-04
PCT/US2014/054043 WO2015035015A1 (en) 2013-09-04 2014-09-04 Liver x receptor (lxr) modulators

Publications (2)

Publication Number Publication Date
MX2016002931A MX2016002931A (es) 2016-07-26
MX371343B true MX371343B (es) 2020-01-27

Family

ID=52628918

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002931A MX371343B (es) 2013-09-04 2014-09-04 Moduladores del receptor x hepatico (lxr).

Country Status (23)

Country Link
US (7) US10047055B2 (es)
EP (2) EP3626712A3 (es)
JP (2) JP6806961B2 (es)
KR (1) KR102281803B1 (es)
CN (2) CN105658636B (es)
AU (1) AU2014315280B2 (es)
BR (1) BR112016004904B1 (es)
CA (1) CA2923175C (es)
CY (1) CY1124057T1 (es)
DK (1) DK3041835T3 (es)
ES (1) ES2804304T3 (es)
HR (1) HRP20201054T1 (es)
HU (1) HUE051094T2 (es)
IL (1) IL244418B (es)
LT (1) LT3041835T (es)
MX (1) MX371343B (es)
PL (1) PL3041835T3 (es)
PT (1) PT3041835T (es)
RS (1) RS60479B1 (es)
SG (1) SG11201601640SA (es)
SI (1) SI3041835T1 (es)
SM (1) SMT202000490T1 (es)
WO (1) WO2015035015A1 (es)

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