HK1254231A1 - 米托-和厚朴酚化合物及其合成方法和用途 - Google Patents

米托-和厚朴酚化合物及其合成方法和用途

Info

Publication number
HK1254231A1
HK1254231A1 HK18113374.9A HK18113374A HK1254231A1 HK 1254231 A1 HK1254231 A1 HK 1254231A1 HK 18113374 A HK18113374 A HK 18113374A HK 1254231 A1 HK1254231 A1 HK 1254231A1
Authority
HK
Hong Kong
Prior art keywords
mito
synthesis
methods
honokiol compounds
honokiol
Prior art date
Application number
HK18113374.9A
Other languages
English (en)
Inventor
Balaraman Kalyanaraman
Jacek Michal Zielonka
Micael J Hardy
Oliver Ouari
Ming You
Original Assignee
Medical College Wisconsin Inc
Aix Marseille Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical College Wisconsin Inc, Aix Marseille Univ filed Critical Medical College Wisconsin Inc
Publication of HK1254231A1 publication Critical patent/HK1254231A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5449—Polyphosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
HK18113374.9A 2015-06-11 2018-10-18 米托-和厚朴酚化合物及其合成方法和用途 HK1254231A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562174185P 2015-06-11 2015-06-11
PCT/US2016/036827 WO2016201188A1 (en) 2015-06-11 2016-06-10 Mito-honokiol compounds and methods of synthesis and use thereof

Publications (1)

Publication Number Publication Date
HK1254231A1 true HK1254231A1 (zh) 2019-07-12

Family

ID=57504627

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18113374.9A HK1254231A1 (zh) 2015-06-11 2018-10-18 米托-和厚朴酚化合物及其合成方法和用途

Country Status (5)

Country Link
US (1) US10836782B2 (zh)
EP (1) EP3307254B1 (zh)
CN (1) CN108883082B (zh)
HK (1) HK1254231A1 (zh)
WO (1) WO2016201188A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10894051B2 (en) * 2017-05-31 2021-01-19 City University Of Hong Kong Method of treating metastatic cancer in a subject
EP3501511A1 (en) 2017-12-22 2019-06-26 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Means for preventing and treating brain metastasis
CN109336748B (zh) * 2018-10-15 2021-11-30 湖北大学 抗nash药物中间体双醛基厚朴酚的制备方法
WO2020124019A1 (en) * 2018-12-14 2020-06-18 The Medical College Of Wisconsin. Inc. Mito-magnolol compounds and methods of synthesis and use thereof
CN110664795B (zh) * 2019-09-20 2022-12-27 广东省禾基生物科技有限公司 水溶性组合物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8168998A (en) 1997-06-26 1999-01-19 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions
WO2000040532A2 (en) 1998-12-31 2000-07-13 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions
US20040105906A1 (en) 2002-03-22 2004-06-03 Arbiser Jack L. Antiagionecic, antitumor, chemopreventative agents
EP1853539A4 (en) 2005-02-23 2010-04-21 Jack L Arbiser HONOKIOL DERIVATIVES TO TREAT PROLIFERATIVE DISEASES
CN101742991A (zh) 2007-05-03 2010-06-16 杰克·L·阿比瑟 和厚朴酚类似物及其在治疗癌症中的用途
WO2015066432A1 (en) 2013-11-01 2015-05-07 Foundation Medicine, Inc. Method of treating post-myeloproliferative neoplasms (mpns) and post-mpn acute myeloid leukemia

Also Published As

Publication number Publication date
CN108883082A (zh) 2018-11-23
US20180134737A1 (en) 2018-05-17
EP3307254A1 (en) 2018-04-18
US10836782B2 (en) 2020-11-17
CN108883082B (zh) 2021-10-26
EP3307254A4 (en) 2019-02-27
WO2016201188A1 (en) 2016-12-15
EP3307254B1 (en) 2020-08-05

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