HK1258056A1 - 治療性化合物和其使用方法 - Google Patents

治療性化合物和其使用方法

Info

Publication number
HK1258056A1
HK1258056A1 HK19100433.4A HK19100433A HK1258056A1 HK 1258056 A1 HK1258056 A1 HK 1258056A1 HK 19100433 A HK19100433 A HK 19100433A HK 1258056 A1 HK1258056 A1 HK 1258056A1
Authority
HK
Hong Kong
Prior art keywords
methods
therapeutic compounds
therapeutic
compounds
Prior art date
Application number
HK19100433.4A
Other languages
English (en)
Inventor
Phillipe Bergeron
Kristen Burford
Sultan Chowdhury
Christoph Martin Dehnhardt
Thilo Focken
Michael Edward Grimwood
Abid Hasan
Kwong Wah Lai
Zhiguo Liu
Steven Mckerrall
Teresa Phuongtram Nguyen
Brian Safina
Daniel Sutherlin
Tao Wang
Original Assignee
健泰科生物技術公司
澤農醫藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 健泰科生物技術公司, 澤農醫藥公司 filed Critical 健泰科生物技術公司
Publication of HK1258056A1 publication Critical patent/HK1258056A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK19100433.4A 2015-09-28 2019-01-11 治療性化合物和其使用方法 HK1258056A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562233863P 2015-09-28 2015-09-28
US201662298817P 2016-02-23 2016-02-23
CN2016096659 2016-08-25
PCT/US2016/054011 WO2017058821A1 (en) 2015-09-28 2016-09-27 Therapeutic compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1258056A1 true HK1258056A1 (zh) 2019-11-01

Family

ID=57137267

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19100433.4A HK1258056A1 (zh) 2015-09-28 2019-01-11 治療性化合物和其使用方法

Country Status (21)

Country Link
US (2) US10787446B2 (zh)
EP (1) EP3356360A1 (zh)
JP (1) JP6987746B2 (zh)
KR (1) KR20180067561A (zh)
CN (1) CN108290881B (zh)
AU (1) AU2016330503B2 (zh)
BR (1) BR112018006189A2 (zh)
CA (1) CA2999769A1 (zh)
CL (1) CL2018000805A1 (zh)
CO (1) CO2018003909A2 (zh)
CR (1) CR20180242A (zh)
HK (1) HK1258056A1 (zh)
IL (1) IL258192A (zh)
MX (1) MX2018003828A (zh)
PE (1) PE20181003A1 (zh)
PH (1) PH12018500668A1 (zh)
RU (1) RU2018115718A (zh)
SG (1) SG10202007787RA (zh)
TW (1) TWI726916B (zh)
WO (1) WO2017058821A1 (zh)
ZA (1) ZA201802134B (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110546148A (zh) * 2017-03-24 2019-12-06 基因泰克公司 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物
CN112321494B (zh) * 2020-11-17 2022-04-19 上海凌凯医药科技有限公司 一种制备2-氯-4-异丙基吡啶的方法
WO2023028056A1 (en) * 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors

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PH12018500668A1 (en) 2018-10-01
AU2016330503B2 (en) 2021-04-08
TW201718556A (zh) 2017-06-01
CL2018000805A1 (es) 2018-07-06
IL258192A (en) 2018-05-31
CO2018003909A2 (es) 2018-07-19
CN108290881A (zh) 2018-07-17
TWI726916B (zh) 2021-05-11
WO2017058821A1 (en) 2017-04-06
US20210171516A1 (en) 2021-06-10
ZA201802134B (en) 2020-08-26
JP2018533551A (ja) 2018-11-15
KR20180067561A (ko) 2018-06-20
RU2018115718A (ru) 2019-10-28
CA2999769A1 (en) 2017-04-06
PE20181003A1 (es) 2018-06-26
CR20180242A (es) 2018-08-10
EP3356360A1 (en) 2018-08-08
US10787446B2 (en) 2020-09-29
BR112018006189A2 (pt) 2018-10-09
AU2016330503A8 (en) 2018-04-19
SG10202007787RA (en) 2020-09-29
RU2018115718A3 (zh) 2019-12-27
MX2018003828A (es) 2018-06-22
AU2016330503A1 (en) 2018-04-12
US20180291014A1 (en) 2018-10-11
JP6987746B2 (ja) 2022-01-05
CN108290881B (zh) 2021-12-07

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