CN101490074B - 5’-修饰的双环核酸类似物 - Google Patents
5’-修饰的双环核酸类似物 Download PDFInfo
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- CN101490074B CN101490074B CN2007800262854A CN200780026285A CN101490074B CN 101490074 B CN101490074 B CN 101490074B CN 2007800262854 A CN2007800262854 A CN 2007800262854A CN 200780026285 A CN200780026285 A CN 200780026285A CN 101490074 B CN101490074 B CN 101490074B
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- compound
- nucleosides
- oligomeric compound
- monomer
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- 0 *[C@@]([C@]1([C@]2O*)O[C@](*)[C@]2OC1)O* Chemical compound *[C@@]([C@]1([C@]2O*)O[C@](*)[C@]2OC1)O* 0.000 description 12
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Abstract
Description
Claims (38)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74705906P | 2006-05-11 | 2006-05-11 | |
US60/747,059 | 2006-05-11 | ||
PCT/US2007/068690 WO2007134181A2 (en) | 2006-05-11 | 2007-05-10 | 5'-modified bicyclic nucleic acid analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101490074A CN101490074A (zh) | 2009-07-22 |
CN101490074B true CN101490074B (zh) | 2013-06-26 |
Family
ID=38686833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800262854A Active CN101490074B (zh) | 2006-05-11 | 2007-05-10 | 5’-修饰的双环核酸类似物 |
Country Status (9)
Country | Link |
---|---|
US (4) | US7547684B2 (zh) |
EP (1) | EP2066684B1 (zh) |
JP (1) | JP5441688B2 (zh) |
CN (1) | CN101490074B (zh) |
AU (1) | AU2007249349B2 (zh) |
CA (1) | CA2651453C (zh) |
DK (1) | DK2066684T3 (zh) |
ES (1) | ES2389737T3 (zh) |
WO (1) | WO2007134181A2 (zh) |
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US20120010393A1 (en) | 2012-01-12 |
WO2007134181A2 (en) | 2007-11-22 |
AU2007249349A1 (en) | 2007-11-22 |
US20070287831A1 (en) | 2007-12-13 |
US8268980B2 (en) | 2012-09-18 |
US7750131B2 (en) | 2010-07-06 |
US8030467B2 (en) | 2011-10-04 |
EP2066684B1 (en) | 2012-07-18 |
CA2651453A1 (en) | 2007-11-22 |
WO2007134181A3 (en) | 2008-01-10 |
CN101490074A (zh) | 2009-07-22 |
EP2066684A2 (en) | 2009-06-10 |
CA2651453C (en) | 2014-10-14 |
JP5441688B2 (ja) | 2014-03-12 |
US7547684B2 (en) | 2009-06-16 |
US20090192302A1 (en) | 2009-07-30 |
AU2007249349B2 (en) | 2012-03-08 |
DK2066684T3 (da) | 2012-10-22 |
JP2009536955A (ja) | 2009-10-22 |
ES2389737T3 (es) | 2012-10-31 |
US20100184966A1 (en) | 2010-07-22 |
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