HU9501994D0 - Novel 5'-substituted nucleosides and oligomers produced therefrom - Google Patents
Novel 5'-substituted nucleosides and oligomers produced therefromInfo
- Publication number
- HU9501994D0 HU9501994D0 HU9501994A HU9501994A HU9501994D0 HU 9501994 D0 HU9501994 D0 HU 9501994D0 HU 9501994 A HU9501994 A HU 9501994A HU 9501994 A HU9501994 A HU 9501994A HU 9501994 D0 HU9501994 D0 HU 9501994D0
- Authority
- HU
- Hungary
- Prior art keywords
- novel
- produced therefrom
- substituted nucleosides
- oligomers produced
- oligomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4075093A | 1993-03-31 | 1993-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU9501994D0 true HU9501994D0 (en) | 1995-09-28 |
Family
ID=21912730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9501994A HU9501994D0 (en) | 1993-03-31 | 1994-03-21 | Novel 5'-substituted nucleosides and oligomers produced therefrom |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0691979A1 (en) |
| JP (1) | JPH08508490A (en) |
| AU (1) | AU6449294A (en) |
| CA (1) | CA2159632A1 (en) |
| HU (1) | HU9501994D0 (en) |
| WO (1) | WO1994022890A1 (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681940A (en) * | 1994-11-02 | 1997-10-28 | Icn Pharmaceuticals | Sugar modified nucleosides and oligonucleotides |
| AU2007258117B2 (en) | 2006-05-05 | 2013-05-30 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating gene expression |
| DK2066684T3 (en) * | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5'-Modified Bicyclic Nucleic Acid Analogs |
| JP2010510807A (en) | 2006-11-27 | 2010-04-08 | アイシス ファーマシューティカルズ， インコーポレーテッド | Methods for treating hypercholesterolemia |
| US8093222B2 (en) | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| EP2125852B1 (en) * | 2007-02-15 | 2016-04-06 | Ionis Pharmaceuticals, Inc. | 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom |
| EP2358398A2 (en) | 2008-10-24 | 2011-08-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
| CN102264374B (en) * | 2008-10-24 | 2015-01-07 | Isis制药公司 | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| AU2010270714B2 (en) | 2009-07-06 | 2015-08-13 | Wave Life Sciences Ltd. | Novel nucleic acid prodrugs and methods use thereof |
| US9102938B2 (en) | 2010-04-01 | 2015-08-11 | Alnylam Pharmaceuticals, Inc. | 2′ and 5′ modified monomers and oligonucleotides |
| US9127033B2 (en) | 2010-04-28 | 2015-09-08 | Isis Pharmaceuticals, Inc. | 5′ modified nucleosides and oligomeric compounds prepared therefrom |
| JP6005628B2 (en) | 2010-04-28 | 2016-10-12 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Modified nucleosides, analogs thereof, and oligomeric compounds prepared therefrom |
| WO2011139695A2 (en) | 2010-04-28 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom |
| WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| BR112013005872A2 (en) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compounds, pharmaceutical composition and their uses |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| DK2734208T3 (en) | 2011-07-19 | 2017-06-19 | Wave Life Sciences Ltd | PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS |
| US20140303235A1 (en) | 2011-08-11 | 2014-10-09 | Isis Pharmaceuticals, Inc. | Linkage modified gapped oligomeric compounds and uses thereof |
| AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| CN104114568B (en) | 2011-12-22 | 2017-09-01 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and the like |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
| US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
| SG11201500232UA (en) | 2012-07-13 | 2015-04-29 | Wave Life Sciences Pte Ltd | Chiral control |
| PT3041854T (en) | 2013-08-08 | 2020-03-05 | Scripps Research Inst | A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
| JPWO2015108048A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant and antitumor agent having antitumor activity |
| JPWO2015108047A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having immunity induction activity and immunity induction activator |
| US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
| DK3129493T3 (en) | 2014-04-09 | 2021-09-27 | Scripps Research Inst | Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters |
| US10221416B2 (en) | 2014-04-24 | 2019-03-05 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising alpha-beta-constrained nucleic acid |
| EP3647318B1 (en) | 2014-04-28 | 2021-06-30 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds |
| EP3408391A4 (en) | 2016-01-31 | 2019-08-28 | University of Massachusetts | Branched oligonucleotides |
| EA201892285A1 (en) | 2016-06-06 | 2019-07-31 | Эрроухэд Фармасьютикалз, Инк. | NUCLEOTIDES MODIFIED BY CYCLOPHOSPHONATE IN REGULATION 5 ' |
| CA3069321A1 (en) | 2017-07-11 | 2019-01-17 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| AU2018309166B2 (en) | 2017-08-03 | 2022-12-08 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| JP7317029B2 (en) | 2018-02-12 | 2023-07-28 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | Modified compounds and uses thereof |
| WO2019165453A1 (en) | 2018-02-26 | 2019-08-29 | Synthorx, Inc. | Il-15 conjugates and uses thereof |
| CN113412268A (en) * | 2019-02-01 | 2021-09-17 | 国立大学法人大阪大学 | 5' -modified nucleoside and nucleotide using the same |
| SG11202107354WA (en) | 2019-02-06 | 2021-08-30 | Synthorx Inc | Il-2 conjugates and methods of use thereof |
| JP2022528840A (en) | 2019-03-26 | 2022-06-16 | ユニバーシティ・オブ・マサチューセッツ | Modified oligonucleotides with increased stability |
| US11879145B2 (en) | 2019-06-14 | 2024-01-23 | The Scripps Research Institute | Reagents and methods for replication, transcription, and translation in semi-synthetic organisms |
| BR112022002307A2 (en) | 2019-08-09 | 2022-06-28 | Univ Massachusetts | CHEMICALLY MODIFIED OLIGONUCLEOTIDES TARGETING SNPS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE139255T1 (en) * | 1989-10-24 | 1996-06-15 | Gilead Sciences Inc | OLIGONUCLEOTIDE ANALOGUES WITH NOVEL BINDINGS |
| DE69115702T2 (en) * | 1990-08-03 | 1996-06-13 | Sterling Winthrop Inc | CONNECTIONS AND METHOD FOR SUPPRESSING GENE EXPRESSION |
| JPH06505704A (en) * | 1990-09-20 | 1994-06-30 | ギリアド サイエンシズ，インコーポレイテッド | Modified internucleoside linkages |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
-
1994
- 1994-03-21 CA CA002159632A patent/CA2159632A1/en not_active Abandoned
- 1994-03-21 EP EP94912265A patent/EP0691979A1/en not_active Withdrawn
- 1994-03-21 HU HU9501994A patent/HU9501994D0/en unknown
- 1994-03-21 AU AU64492/94A patent/AU6449294A/en not_active Abandoned
- 1994-03-21 WO PCT/US1994/002993 patent/WO1994022890A1/en not_active Application Discontinuation
- 1994-03-21 JP JP6522131A patent/JPH08508490A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2159632A1 (en) | 1994-10-13 |
| EP0691979A1 (en) | 1996-01-17 |
| WO1994022890A1 (en) | 1994-10-13 |
| JPH08508490A (en) | 1996-09-10 |
| AU6449294A (en) | 1994-10-24 |
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