MX2020013653A - Compuestos y metodos para la reduccion de la expresion de lrrk2. - Google Patents

Compuestos y metodos para la reduccion de la expresion de lrrk2.

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Publication number
MX2020013653A
MX2020013653A MX2020013653A MX2020013653A MX2020013653A MX 2020013653 A MX2020013653 A MX 2020013653A MX 2020013653 A MX2020013653 A MX 2020013653A MX 2020013653 A MX2020013653 A MX 2020013653A MX 2020013653 A MX2020013653 A MX 2020013653A
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MX
Mexico
Prior art keywords
compounds
methods
reducing
animal
cell
Prior art date
Application number
MX2020013653A
Other languages
English (en)
Inventor
Holly Kordasiewicz
Huynh-Hoa Bui
Susan M Freier
Tracy A Cole
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2020013653A publication Critical patent/MX2020013653A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

Abstract

Se proporcionan compuestos, métodos y composiciones farmacéuticas para reducir la cantidad o la actividad del ARN de LRRK2 en una célula o animal, y en determinados casos para reducir la cantidad de proteína LRRK2 en una célula o animal. Tales compuestos, métodos y composiciones farmacéuticas son útiles para mejorar al menos un síntoma o característica de una enfermedad neurodegenerativa. Dichos síntomas y características incluyen ataxia, neuropatía y formación de agregados. Tales enfermedades neurodegenerativas incluyen enfermedad de Parkinson.
MX2020013653A 2018-06-27 2019-06-27 Compuestos y metodos para la reduccion de la expresion de lrrk2. MX2020013653A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862690790P 2018-06-27 2018-06-27
PCT/US2019/039558 WO2020006267A1 (en) 2018-06-27 2019-06-27 Compounds and methods for reducing lrrk2 expression

Publications (1)

Publication Number Publication Date
MX2020013653A true MX2020013653A (es) 2021-03-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020013653A MX2020013653A (es) 2018-06-27 2019-06-27 Compuestos y metodos para la reduccion de la expresion de lrrk2.

Country Status (22)

Country Link
US (2) US11332746B1 (es)
EP (1) EP3814503A4 (es)
JP (2) JP7315594B2 (es)
KR (1) KR20210025055A (es)
CN (1) CN112400019B (es)
AR (1) AR116102A1 (es)
AU (1) AU2019294838A1 (es)
BR (1) BR112020024564A2 (es)
CA (1) CA3104676A1 (es)
CL (1) CL2020003309A1 (es)
CO (1) CO2020015256A2 (es)
CR (1) CR20210044A (es)
EA (1) EA202190140A1 (es)
IL (1) IL279632A (es)
JO (1) JOP20200334A1 (es)
MX (1) MX2020013653A (es)
PE (1) PE20210518A1 (es)
PH (1) PH12021500003A1 (es)
SG (1) SG11202011864XA (es)
UY (1) UY38282A (es)
WO (1) WO2020006267A1 (es)
ZA (1) ZA202007444B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3006599A1 (en) 2016-01-05 2017-07-13 Ionis Pharmaceuticals, Inc. Methods for reducing lrrk2 expression
EP3737387A1 (en) 2018-01-12 2020-11-18 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
WO2019169243A1 (en) 2018-03-02 2019-09-06 Ionis Pharmaceuticals, Inc. Compounds and methods for the modulation of amyloid-beta precursor protein
EP3814348B9 (en) 2018-06-27 2023-11-01 Bristol-Myers Squibb Company Substituted naphthyridinone compounds useful as t cell activators
JOP20200334A1 (ar) 2018-06-27 2020-12-20 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير الوراثي عن lrrk2
WO2021224320A1 (en) 2020-05-06 2021-11-11 Les Laboratoires Servier New macrocyclic lrrk2 kinase inhibitors
UY39344A (es) * 2020-07-28 2022-02-25 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir la expresión de app
IL305877A (en) 2021-03-18 2023-11-01 Servier Lab Macrocyclic LRRK2 kinase inhibitors
CN115137744A (zh) * 2021-03-30 2022-10-04 南京大学 一种用于治疗帕金森的rna质粒递送系统
US11578329B2 (en) 2021-04-19 2023-02-14 Novo Nordisk A/S Compositions and methods for inhibiting nuclear receptor subfamily 1 group H member 3 (NR1H3) expression
WO2022226018A1 (en) * 2021-04-20 2022-10-27 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Malignant mesothelioma susceptibility as a result of germline leucine-rich repeat kinase 2 (lrrk2) alterations
KR20240033237A (ko) * 2021-06-29 2024-03-12 알닐람 파마슈티칼스 인코포레이티드 류신이 풍부한 반복 키나아제 2(LRRK2) iRNA 제제 조성물 및 이의 사용 방법
WO2023144263A1 (en) * 2022-01-26 2023-08-03 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons

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