KR20210025055A - Lrrk2 발현 감소용 화합물 및 방법 - Google Patents
Lrrk2 발현 감소용 화합물 및 방법 Download PDFInfo
- Publication number
- KR20210025055A KR20210025055A KR1020217001678A KR20217001678A KR20210025055A KR 20210025055 A KR20210025055 A KR 20210025055A KR 1020217001678 A KR1020217001678 A KR 1020217001678A KR 20217001678 A KR20217001678 A KR 20217001678A KR 20210025055 A KR20210025055 A KR 20210025055A
- Authority
- KR
- South Korea
- Prior art keywords
- modified
- seq
- nucleobase
- certain embodiments
- oligomeric compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 277
- 238000000034 method Methods 0.000 title claims abstract description 38
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 title claims abstract description 15
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 title claims abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 50
- 241001465754 Metazoa Species 0.000 claims abstract description 31
- 208000018737 Parkinson disease Diseases 0.000 claims abstract description 31
- 230000004770 neurodegeneration Effects 0.000 claims abstract description 17
- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 17
- 201000001119 neuropathy Diseases 0.000 claims abstract description 10
- 230000007823 neuropathy Effects 0.000 claims abstract description 10
- 208000033808 peripheral neuropathy Diseases 0.000 claims abstract description 10
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 9
- 206010003591 Ataxia Diseases 0.000 claims abstract description 7
- 108091034117 Oligonucleotide Proteins 0.000 claims description 1678
- 125000005647 linker group Chemical group 0.000 claims description 290
- 239000002777 nucleoside Substances 0.000 claims description 237
- 235000000346 sugar Nutrition 0.000 claims description 216
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 177
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 175
- 230000000295 complement effect Effects 0.000 claims description 146
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 140
- 125000003835 nucleoside group Chemical group 0.000 claims description 113
- 150000007523 nucleic acids Chemical class 0.000 claims description 111
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 105
- 102000039446 nucleic acids Human genes 0.000 claims description 94
- 108020004707 nucleic acids Proteins 0.000 claims description 94
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 92
- 150000004713 phosphodiesters Chemical class 0.000 claims description 84
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 47
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 46
- 230000000692 anti-sense effect Effects 0.000 claims description 40
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 39
- 125000002619 bicyclic group Chemical group 0.000 claims description 33
- 238000012986 modification Methods 0.000 claims description 32
- YIMATHOGWXZHFX-WCTZXXKLSA-N (2r,3r,4r,5r)-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolane-2,4-diol Chemical compound COCCO[C@H]1[C@H](O)O[C@H](CO)[C@H]1O YIMATHOGWXZHFX-WCTZXXKLSA-N 0.000 claims description 31
- 230000004048 modification Effects 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 24
- 229940113082 thymine Drugs 0.000 claims description 24
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 23
- 229930024421 Adenine Natural products 0.000 claims description 23
- 229960000643 adenine Drugs 0.000 claims description 23
- 108020004459 Small interfering RNA Proteins 0.000 claims description 22
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 12
- 108091030071 RNAI Proteins 0.000 claims description 10
- 230000009368 gene silencing by RNA Effects 0.000 claims description 10
- 239000003085 diluting agent Substances 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 159000000000 sodium salts Chemical class 0.000 claims description 8
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 7
- 150000008163 sugars Chemical class 0.000 claims description 6
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000001668 ameliorated effect Effects 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 60
- 102000053602 DNA Human genes 0.000 description 1323
- 108020004414 DNA Proteins 0.000 description 1322
- 101000941879 Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Proteins 0.000 description 177
- 102100032693 Leucine-rich repeat serine/threonine-protein kinase 2 Human genes 0.000 description 123
- 210000004027 cell Anatomy 0.000 description 79
- 102000056111 human LRRK2 Human genes 0.000 description 53
- 238000011282 treatment Methods 0.000 description 40
- -1 bicyclic nucleoside Chemical class 0.000 description 35
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 34
- 241000699670 Mus sp. Species 0.000 description 33
- 238000000338 in vitro Methods 0.000 description 33
- 239000000523 sample Substances 0.000 description 32
- 241000700159 Rattus Species 0.000 description 26
- 238000003556 assay Methods 0.000 description 25
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 25
- 239000002953 phosphate buffered saline Substances 0.000 description 25
- 230000009467 reduction Effects 0.000 description 25
- 239000000126 substance Substances 0.000 description 24
- 241000282414 Homo sapiens Species 0.000 description 23
- 108091028043 Nucleic acid sequence Proteins 0.000 description 19
- 125000000217 alkyl group Chemical group 0.000 description 19
- 239000007924 injection Substances 0.000 description 18
- 238000002347 injection Methods 0.000 description 18
- 230000002829 reductive effect Effects 0.000 description 18
- 125000004429 atom Chemical group 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 16
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 14
- 229940104302 cytosine Drugs 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 125000001424 substituent group Chemical group 0.000 description 14
- 238000011529 RT qPCR Methods 0.000 description 12
- 230000007423 decrease Effects 0.000 description 12
- 230000001404 mediated effect Effects 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 10
- 238000004520 electroporation Methods 0.000 description 10
- 239000012634 fragment Substances 0.000 description 10
- 229910019142 PO4 Inorganic materials 0.000 description 9
- 125000003843 furanosyl group Chemical group 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 231100000673 dose–response relationship Toxicity 0.000 description 8
- 238000009396 hybridization Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 108091093088 Amplicon Proteins 0.000 description 7
- 102220577899 Leucine-rich repeat serine/threonine-protein kinase 2_G2019S_mutation Human genes 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 238000003776 cleavage reaction Methods 0.000 description 7
- 239000006184 cosolvent Substances 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 7
- 230000000977 initiatory effect Effects 0.000 description 7
- 230000000670 limiting effect Effects 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000010452 phosphate Substances 0.000 description 7
- 235000021317 phosphate Nutrition 0.000 description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
- 230000002441 reversible effect Effects 0.000 description 7
- 230000007017 scission Effects 0.000 description 7
- 238000006467 substitution reaction Methods 0.000 description 7
- 229940035893 uracil Drugs 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 238000007913 intrathecal administration Methods 0.000 description 6
- 230000007659 motor function Effects 0.000 description 6
- 230000035772 mutation Effects 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 239000008177 pharmaceutical agent Substances 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 125000006239 protecting group Chemical group 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 210000000278 spinal cord Anatomy 0.000 description 6
- 238000011830 transgenic mouse model Methods 0.000 description 6
- 102100034343 Integrase Human genes 0.000 description 5
- 101710203526 Integrase Proteins 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000000304 alkynyl group Chemical group 0.000 description 5
- 102000003802 alpha-Synuclein Human genes 0.000 description 5
- 108090000185 alpha-Synuclein Proteins 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 210000003710 cerebral cortex Anatomy 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 5
- 210000001577 neostriatum Anatomy 0.000 description 5
- 239000000651 prodrug Substances 0.000 description 5
- 229940002612 prodrug Drugs 0.000 description 5
- 150000003212 purines Chemical class 0.000 description 5
- 150000003230 pyrimidines Chemical group 0.000 description 5
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 description 4
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 description 4
- PEHVGBZKEYRQSX-UHFFFAOYSA-N 7-deaza-adenine Chemical compound NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 description 4
- 108010072220 Cyclophilin A Proteins 0.000 description 4
- 241000699660 Mus musculus Species 0.000 description 4
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 4
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 4
- 108700019146 Transgenes Proteins 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 230000001588 bifunctional effect Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 210000001259 mesencephalon Anatomy 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000003753 real-time PCR Methods 0.000 description 4
- 238000012453 sprague-dawley rat model Methods 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 150000003568 thioethers Chemical class 0.000 description 4
- 230000009261 transgenic effect Effects 0.000 description 4
- 102000010970 Connexin Human genes 0.000 description 3
- 108050001175 Connexin Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 241000282560 Macaca mulatta Species 0.000 description 3
- 108091027974 Mature messenger RNA Proteins 0.000 description 3
- 101710163270 Nuclease Proteins 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 210000005013 brain tissue Anatomy 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 210000003976 gap junction Anatomy 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 108091027963 non-coding RNA Proteins 0.000 description 3
- 102000042567 non-coding RNA Human genes 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 230000007115 recruitment Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000008223 sterile water Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000010189 synthetic method Methods 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- 150000003573 thiols Chemical class 0.000 description 3
- 230000002103 transcriptional effect Effects 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- QGVQZRDQPDLHHV-DPAQBDIFSA-N (3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-3-thiol Chemical compound C1C=C2C[C@@H](S)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 QGVQZRDQPDLHHV-DPAQBDIFSA-N 0.000 description 2
- RUVRGYVESPRHSZ-UHFFFAOYSA-N 2-[2-(2-azaniumylethoxy)ethoxy]acetate Chemical compound NCCOCCOCC(O)=O RUVRGYVESPRHSZ-UHFFFAOYSA-N 0.000 description 2
- FZWGECJQACGGTI-UHFFFAOYSA-N 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one Chemical compound NC1=NC(O)=C2N(C)C=NC2=N1 FZWGECJQACGGTI-UHFFFAOYSA-N 0.000 description 2
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 2
- CFIBTBBTJWHPQV-UHFFFAOYSA-N 2-methyl-n-(6-oxo-3,7-dihydropurin-2-yl)propanamide Chemical compound N1C(NC(=O)C(C)C)=NC(=O)C2=C1N=CN2 CFIBTBBTJWHPQV-UHFFFAOYSA-N 0.000 description 2
- OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 2
- OLXZPDWKRNYJJZ-UHFFFAOYSA-N 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol Chemical group C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(CO)O1 OLXZPDWKRNYJJZ-UHFFFAOYSA-N 0.000 description 2
- RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 description 2
- QQJXZVKXNSFHRI-UHFFFAOYSA-N 6-Benzamidopurine Chemical compound N=1C=NC=2N=CNC=2C=1NC(=O)C1=CC=CC=C1 QQJXZVKXNSFHRI-UHFFFAOYSA-N 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
- HCGHYQLFMPXSDU-UHFFFAOYSA-N 7-methyladenine Chemical compound C1=NC(N)=C2N(C)C=NC2=N1 HCGHYQLFMPXSDU-UHFFFAOYSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 208000035657 Abasia Diseases 0.000 description 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 2
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 125000000824 D-ribofuranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@]1([H])O[H] 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 2
- 108091006109 GTPases Proteins 0.000 description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 2
- 101100021877 Homo sapiens LRRK2 gene Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 101150081013 LRRK2 gene Proteins 0.000 description 2
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 2
- 102220577984 Leucine-rich repeat serine/threonine-protein kinase 2_I2020T_mutation Human genes 0.000 description 2
- 102220596654 Leucine-rich repeat serine/threonine-protein kinase 2_R1441C_mutation Human genes 0.000 description 2
- 102220579336 Leucine-rich repeat serine/threonine-protein kinase 2_R1441G_mutation Human genes 0.000 description 2
- 102220577884 Leucine-rich repeat serine/threonine-protein kinase 2_Y1699C_mutation Human genes 0.000 description 2
- 108700011259 MicroRNAs Proteins 0.000 description 2
- 101000834887 Mus musculus Alpha-synuclein Proteins 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 239000012083 RIPA buffer Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 125000004103 aminoalkyl group Chemical group 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 210000005064 dopaminergic neuron Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 125000001033 ether group Chemical group 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical class 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003447 ipsilateral effect Effects 0.000 description 2
- 210000004901 leucine-rich repeat Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 2
- 238000009126 molecular therapy Methods 0.000 description 2
- XBDUZBHKKUFFRH-UHFFFAOYSA-N n-(2-oxo-1h-pyrimidin-6-yl)benzamide Chemical compound OC1=NC=CC(NC(=O)C=2C=CC=CC=2)=N1 XBDUZBHKKUFFRH-UHFFFAOYSA-N 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- RDOWQLZANAYVLL-UHFFFAOYSA-N phenanthridine Chemical compound C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 229920000768 polyamine Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 229950008882 polysorbate Drugs 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 125000005309 thioalkoxy group Chemical group 0.000 description 2
- 238000011824 transgenic rat model Methods 0.000 description 2
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical group C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 description 1
- DIIIISSCIXVANO-UHFFFAOYSA-N 1,2-Dimethylhydrazine Chemical compound CNNC DIIIISSCIXVANO-UHFFFAOYSA-N 0.000 description 1
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 description 1
- UHUHBFMZVCOEOV-UHFFFAOYSA-N 1h-imidazo[4,5-c]pyridin-4-amine Chemical compound NC1=NC=CC2=C1N=CN2 UHUHBFMZVCOEOV-UHFFFAOYSA-N 0.000 description 1
- ZMZGFLUUZLELNE-UHFFFAOYSA-N 2,3,5-triiodobenzoic acid Chemical compound OC(=O)C1=CC(I)=CC(I)=C1I ZMZGFLUUZLELNE-UHFFFAOYSA-N 0.000 description 1
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 1
- QSHACTSJHMKXTE-UHFFFAOYSA-N 2-(2-aminopropyl)-7h-purin-6-amine Chemical compound CC(N)CC1=NC(N)=C2NC=NC2=N1 QSHACTSJHMKXTE-UHFFFAOYSA-N 0.000 description 1
- BRLJKBOXIVONAG-UHFFFAOYSA-N 2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]acetic acid Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)N(C)CC(O)=O BRLJKBOXIVONAG-UHFFFAOYSA-N 0.000 description 1
- JRYMOPZHXMVHTA-DAGMQNCNSA-N 2-amino-7-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JRYMOPZHXMVHTA-DAGMQNCNSA-N 0.000 description 1
- WKMPTBDYDNUJLF-UHFFFAOYSA-N 2-fluoroadenine Chemical compound NC1=NC(F)=NC2=C1N=CN2 WKMPTBDYDNUJLF-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- USCCECGPGBGFOM-UHFFFAOYSA-N 2-propyl-7h-purin-6-amine Chemical compound CCCC1=NC(N)=C2NC=NC2=N1 USCCECGPGBGFOM-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- ASFAFOSQXBRFMV-LJQANCHMSA-N 3-n-(2-benzyl-1,3-dihydroxypropan-2-yl)-1-n-[(1r)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide Chemical compound N([C@H](C)C=1C=CC(F)=CC=1)C(=O)C(C=1)=CC(N(C)S(C)(=O)=O)=CC=1C(=O)NC(CO)(CO)CC1=CC=CC=C1 ASFAFOSQXBRFMV-LJQANCHMSA-N 0.000 description 1
- ZLAQATDNGLKIEV-UHFFFAOYSA-N 5-methyl-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CC1=CNC(=S)NC1=O ZLAQATDNGLKIEV-UHFFFAOYSA-N 0.000 description 1
- KXBCLNRMQPRVTP-UHFFFAOYSA-N 6-amino-1,5-dihydroimidazo[4,5-c]pyridin-4-one Chemical compound O=C1NC(N)=CC2=C1N=CN2 KXBCLNRMQPRVTP-UHFFFAOYSA-N 0.000 description 1
- DCPSTSVLRXOYGS-UHFFFAOYSA-N 6-amino-1h-pyrimidine-2-thione Chemical compound NC1=CC=NC(S)=N1 DCPSTSVLRXOYGS-UHFFFAOYSA-N 0.000 description 1
- QNNARSZPGNJZIX-UHFFFAOYSA-N 6-amino-5-prop-1-ynyl-1h-pyrimidin-2-one Chemical compound CC#CC1=CNC(=O)N=C1N QNNARSZPGNJZIX-UHFFFAOYSA-N 0.000 description 1
- CKOMXBHMKXXTNW-UHFFFAOYSA-N 6-methyladenine Chemical compound CNC1=NC=NC2=C1N=CN2 CKOMXBHMKXXTNW-UHFFFAOYSA-N 0.000 description 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
- LOSIULRWFAEMFL-UHFFFAOYSA-N 7-deazaguanine Chemical compound O=C1NC(N)=NC2=C1CC=N2 LOSIULRWFAEMFL-UHFFFAOYSA-N 0.000 description 1
- 241000023308 Acca Species 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000016904 Armadillo Domain Proteins Human genes 0.000 description 1
- 108010014223 Armadillo Domain Proteins Proteins 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 102000000131 Beta tubulin Human genes 0.000 description 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 241000289632 Dasypodidae Species 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000908713 Homo sapiens Dihydrofolate reductase Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 108091046869 Telomeric non-coding RNA Proteins 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- RLXCFCYWFYXTON-JTTSDREOSA-N [(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-16-yl] N-hexylcarbamate Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(OC(=O)NCCCCCC)[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 RLXCFCYWFYXTON-JTTSDREOSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- XVIYCJDWYLJQBG-UHFFFAOYSA-N acetic acid;adamantane Chemical group CC(O)=O.C1C(C2)CC3CC1CC2C3 XVIYCJDWYLJQBG-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 101150084233 ago2 gene Proteins 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000005600 alkyl phosphonate group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 238000012098 association analyses Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 208000036815 beta tubulin Diseases 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 150000003857 carboxamides Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
- 229960003184 carprofen Drugs 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960002155 chlorothiazide Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 125000003716 cholic acid group Chemical group 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 210000005257 cortical tissue Anatomy 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 108700007153 dansylsarcosine Proteins 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- GTZOYNFRVVHLDZ-UHFFFAOYSA-N dodecane-1,1-diol Chemical group CCCCCCCCCCCC(O)O GTZOYNFRVVHLDZ-UHFFFAOYSA-N 0.000 description 1
- 210000004002 dopaminergic cell Anatomy 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000012039 electrophile Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000009088 enzymatic function Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 1
- 229960001395 fenbufen Drugs 0.000 description 1
- 229960000556 fingolimod Drugs 0.000 description 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 description 1
- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
- 229960004369 flufenamic acid Drugs 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
- 235000008191 folinic acid Nutrition 0.000 description 1
- 239000011672 folinic acid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000004744 fore-foot Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000030279 gene silencing Effects 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000138 intercalating agent Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229960001691 leucovorin Drugs 0.000 description 1
- 239000002479 lipoplex Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- FMKLITBCOZWOEX-UHFFFAOYSA-N n-(5-methyl-2-oxo-1h-pyrimidin-6-yl)benzamide Chemical compound CC1=CNC(=O)N=C1NC(=O)C1=CC=CC=C1 FMKLITBCOZWOEX-UHFFFAOYSA-N 0.000 description 1
- 230000010807 negative regulation of binding Effects 0.000 description 1
- 230000009251 neurologic dysfunction Effects 0.000 description 1
- 208000015015 neurological dysfunction Diseases 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 239000012038 nucleophile Substances 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- ONTNXMBMXUNDBF-UHFFFAOYSA-N pentatriacontane-17,18,19-triol Chemical compound CCCCCCCCCCCCCCCCC(O)C(O)C(O)CCCCCCCCCCCCCCCC ONTNXMBMXUNDBF-UHFFFAOYSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical group 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- HBCQSNAFLVXVAY-UHFFFAOYSA-N pyrimidine-2-thiol Chemical compound SC1=NC=CC=N1 HBCQSNAFLVXVAY-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 125000006853 reporter group Chemical group 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 125000004962 sulfoxyl group Chemical group 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000003527 tetrahydropyrans Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 125000002640 tocopherol group Chemical group 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
세포 또는 동물에서 LRRK2 RNA의 양 또는 활성 감소용, 그리고 특정 사례에서 세포 또는 동물에서 LRRK2 단백질의 양 감소용 화합물, 방법, 및 약제학적 조성물이 제공된다. 상기 화합물, 방법, 및 약제학적 조성물은 신경퇴행성 질환의 적어도 5 하나의 징후 또는 특징을 개선하는데 유용하다. 그와 같은 징후 및 특징은 운동실조증, 신경병증, 및 응집체 형성을 포함한다. 그와 같은 신경퇴행성 질환은 파킨슨병을 포함한다.
Description
서열 목록
본원은 전자 형태의 서열 목록과 함께 출원 중이다. 서열 목록은, 크기가 1.12 MB인, 2019년 6월 14일 창작된, 파일명 BIOL0324WOSEQ_ST25.txt로서 제공된다. 서열 목록의 전자 형태의 정보는 본 명세서에 참고로 전체적으로 편입된다.
분야
세포 또는 동물에서 류신-풍부 반복 키나제 2 (LRRK2) RNA의 양 또는 활성 감소용, 그리고 특정 사례에서 세포 또는 동물에서 LRRK2 단백질의 양 감소용 화합물, 방법, 및 약제학적 조성물이 제공된다. 상기 화합물, 방법, 및 약제학적 조성물은 신경퇴행성 질환의 적어도 하나의 징후 또는 특징을 개선하는데 유용하다. 그와 같은 징후 및 특징은 운동실조증, 신경병증, 및 응집체 형성을 포함한다. 그와 같은 신경퇴행성 질환은 파킨슨병을 포함한다.
LRRK2 유전자는 아르마딜로 반복 (ARM) 영역, 안키린 반복 (ANK) 영역, 류신-풍부 반복 (LRR) 도메인, 키나제 도메인, RAS 도메인, GTPase 도메인, 및 WD40 도메인을 가진 단백질을 인코딩한다. 단백질은 주로 세포질에서 존재하지만 또한 미토콘드리아 외막과 회합한다. LRRK2 단백질의 1개 단편은 류신이 풍부하고 신호 전달 및 세포골격 조립에서 관여될 수 있다. LRRK2 단백질의 다른 부분은 또한 단백질-단백질 상호작용에서 관여된다고 생각된다. 추가의 연구는 LRRK2 단백질이, 인산화 및 GTPase 활성을 포함하는, 키나제 활성으로서 공지된 효소 기능을 갖는다는 것을 명시한다. LRRK2는 바디 전반에 걸쳐 뇌 및 기타 조직에서 활성이다.
전장 유전체 연관성 분석은 LRRK2와 파킨슨병 사이 연관을 발견하였다. 사실, LRRK2는 파킨슨병에 대한 최대 공지된 유전 기여자이다. 그럼에도 불구하고, 파킨슨병은 유전병으로 간주되어 오지 않았다. 대부분의 파킨슨병은 특발성이다. 파킨슨병의 대략 10 퍼센트는 유전적 원인에 연결되어 왔다. LRRK2 유전자에서 돌연변이는, 총 파킨슨병 사례의 1 내지 2 퍼센트를 나타내는, 이러한 비교적 소그룹에서 파킨슨병의 가장 흔한 원인이다.
현재 신경퇴행성 질환 예컨대, 비-LRRK2 매개된 파킨슨병을 포함하는, 파킨슨병 치료에 대하여 허용가능한 옵션은 부족하다. 그러므로 그러한 질환의 치료용 화합물, 방법, 및 약제학적 조성물을 제공하는 것이 본 명세서에서 목적이다.
세포 또는 동물에서 LRRK2 RNA의 양 또는 활성 감소용, 그리고 특정 구현예에서 LRRK2 단백질의 양 감소용 화합물, 방법, 및 약제학적 조성물은 본 명세서에 제공된다. 특정 구현예에서, 동물은 신경퇴행성 질환을 가지고 있다. 특정 구현예에서, 동물은 파킨슨병을 가지고 있다. 특정 구현예에서, LRRK2 RNA의 발현 감소에 유용한 화합물은 올리고머성 화합물이다. 특정 구현예에서, LRRK2 RNA의 발현 감소에 유용한 화합물은 변형된 올리고뉴클레오타이드이다.
신경퇴행성 질환의 적어도 하나의 징후 또는 특징의 개선에 유용한 방법은 또한 제공된다. 특정 구현예에서, 신경퇴행성 질환은 파킨슨병이다. 특정 구현예에서 파킨슨병은 어느 한쪽 LRRK2 매개된 파킨슨병 또는 비-LRRK2 매개된 파킨슨병이다. 특정 구현예에서, 징후 또는 특징은 운동실조증, 신경병증, 및 응집체 형성을 포함한다. 특정 구현예에서, 이들 징후의 개선은 개선된 운동 기능, 감소된 신경병증, 및 응집체의 수에서 감소를 초래한다.
상술한 일반적인 설명 및 하기 상세한 설명 둘 모두가 단지 예시적이고 설명적이며 제한적이지 않는다는 것을 이해해야 한다. 본 명세서에서, 단수의 사용은 달리 구체적으로 언급되지 않는 한 복수를 포함한다. 본 명세서에 사용된 바와 같이, "또는"의 사용은 달리 언급되지 않는 한 "및/또는"을 의미한다. 게다가, 용어 "포함하는" 뿐만 아니라 다른 형태, 예컨대 "포함한다" 및 "포함된"의 사용은 비제한적이다. 또한, 용어 예컨대 "요소" 또는 "성분"은, 달리 구체적으로 언급되지 않는 한, 1개의 유닛을 포함하는 요소 및 성분 그리고 1개 초과의 서브유닛을 포함하는 요소 및 성분 둘 모두를 포괄한다.
본 명세서에 사용된 섹션 제목은 단지 조직상의 목적이고 기재된 요지 제한으로서 해석되지 않아야 한다. 비제한적으로, 특허, 특허 출원, 기사, 서적, 및 논문을 포함하는, 본원에서 인용된, 모든 문서, 또는 문서의 부분들은 본 명세서에 논의된 문서의 부분으로, 뿐만 아니라 전체적으로 참고로 이로써 명시적으로 편입된다.
정의
구체적 정의가 제공되지 않는 한, 본 명세서에 기재된 분석 화학, 유기 합성 화학, 그리고 의료 화학 및 약화학의 절차 및 기술, 그리고 상기와 관련하여 사용된 명명법은 당해 기술에서 흔하게 사용되고 널리 공지된 것들이다. 허용되는 경우, 본 개시내용에서 전반에 걸쳐 지칭된 모든 특허, 출원, 공개 출원 및 기타 공보 그리고 기타 데이터는 본 명세서에 참고로 전체적으로 편입된다.
달리 나타내지 않는 한, 하기 용어는 하기 의미를 갖는다:
정의
본 명세서에 사용된 바와 같이, "2'-데옥시뉴클레오사이드"는, 자연 발생 데옥시리보핵산 (DNA)에서 발견된 대로, 2'-H(H) 데옥시리보실 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 특정 구현예에서, 2'-데옥시뉴클레오사이드는 변형된 핵염기를 포함할 수 있거나 RNA 핵염기 (우라실)을 포함할 수 있다.
본 명세서에 사용된 바와 같이, "2'-치환된 뉴클레오사이드"는 2'-치환된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 본 명세서에 사용된 바와 같이, 당 모이어티와 관련하여 "2'-치환된"은 H 또는 OH 이외 적어도 하나의 2'-치환기를 포함하는 당 모이어티를 의미한다.
본 명세서에 사용된 바와 같이, "5-메틸 시토신"은 5번 위치에 부착된 메틸기로 변형된 시토신을 의미한다. 5-메틸 시토신은 변형된 핵염기이다.
본 명세서에 사용된 바와 같이, "투여하는"은 약제학적 제제를 동물에 제공하는 것을 의미한다.
본 명세서에 사용된 바와 같이, "동물"은 인간 또는 비-인간 동물을 의미한다.
본 명세서에 사용된 바와 같이, "안티센스 활성"은 그것의 표적 핵산에 대한 안티센스 화합물의 하이브리드화에 기인하는 임의의 검출가능한 및/또는 측정가능한 변화를 의미한다. 특정 구현예에서, 안티센스 활성은 안티센스 화합물의 부재 하에서 표적 핵산 수준 또는 표적 단백질 수준에 비교된 그와 같은 표적 핵산에 의해 인코딩된 표적 핵산 또는 단백질의 양 또는 발현에서 감소이다.
본 명세서에 사용된 바와 같이, "안티센스 화합물"은 하나 이상의 안티센스 활성을 달성할 수 있는 올리고머성 화합물을 의미한다.
본 명세서에 사용된 바와 같이, 치료와 관련하여 "개선한다"는 치료의 부재 하에서 동일한 증상에 비하여 적어도 하나의 증상에서 개선을 의미한다. 특정 구현예에서, 개선은 증상의 중증도 또는 빈도에서 감소 또는 증상의 중증도 또는 빈도에서 지연된 개시 또는 진행의 저속화이다. 특정 구현예에서, 징후 또는 특징은 운동실조증, 신경병증, 및 응집체 형성이다. 특정 구현예에서, 이들 증상의 개선은 개선된 운동 기능, 감소된 신경병증, 및 응집체의 수에서 감소를 초래한다.
본 명세서에 사용된 바와 같이, "이환형 뉴클레오사이드" 또는 "BNA"는 이환형 당 모이어티를 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "이환형 당" 또는 "이환형 당 모이어티"는 2개의 고리를 포함하는 변형된 당 모이어티를 의미하고, 여기서 제2 고리는 제1 고리에서 원자들 중 2개를 연결하는 브릿지를 통해 형성되어 그것에 의해 이환형 구조를 형성한다. 특정 구현예에서, 이환형 당 모이어티의 제1 고리는 푸라노실 모이어티이다. 특정 구현예에서, 이환형 당 모이어티는 푸라노실 모이어티를 포함하지 않는다.
본 명세서에 사용된 바와 같이, "절단가능한 모이어티"는, 예를 들어, 세포, 동물, 또는 인간 내부에서, 생리적 조건 하에서 절단되는 원자의 그룹 또는 결합을 의미한다.
본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드와 관련하여 "상보성"은 올리고뉴클레오타이드 또는 이의 하나 이상의 영역의 핵염기 및 또 다른 핵산 또는 이의 하나 이상의 영역의 핵염기의 적어도 70%가 올리고뉴클레오타이드 및 다른 핵산의 핵염기 서열이 대향하는 방향으로 정렬되는 경우 서로와 수소 결합할 수 있다는 것을 의미한다. 상보성 핵염기는 서로와 수소 결합을 형성할 수 있는 핵염기를 의미한다. 상보성 핵염기 쌍은 아데닌 (A) 및 티민 (T), 아데닌 (A) 및 우라실 (U), 시토신 (C) 및 구아닌 (G), 5-메틸 시토신 (mC) 및 구아닌 (G)를 포함한다. 상보성 올리고뉴클레오타이드 및/또는 핵산은 각 뉴클레오사이드에 핵염기 상보성을 가질 필요가 없다. 오히려, 일부 미스매치는 용인된다. 본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드와 관련하여 "완전하게 상보성" 또는 "100% 상보성"은 올리고뉴클레오타이드가 또 다른 올리고뉴클레오타이드 또는 올리고뉴클레오타이드의 각 뉴클레오사이드의 핵산에 상보성이라는 것을 의미한다.
본 명세서에 사용된 바와 같이, "컨쥬게이트 그룹"은 올리고뉴클레오타이드에 직접적으로 부착되는 원자의 그룹을 의미한다. 컨쥬게이트 그룹은 컨쥬게이트 모이어티를 올리고뉴클레오타이드에 부착시키는 컨쥬게이트 링커 및 컨쥬게이트 모이어티를 포함한다.
본 명세서에 사용된 바와 같이, "컨쥬게이트 링커"는 컨쥬게이트 모이어티를 올리고뉴클레오타이드에 연결시키는 적어도 하나의 결합을 포함하는 원자의 그룹 또는 단일 결합을 의미한다.
본 명세서에 사용된 바와 같이, "컨쥬게이트 모이어티"는 컨쥬게이트 링커를 통해 올리고뉴클레오타이드에 부착되는 원자의 그룹을 의미한다.
본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드의 맥락에서 "연속적"은 서로에 바로 인접한 뉴클레오사이드, 핵염기, 당 모이어티, 또는 인터뉴클레오사이드 연결기를 지칭한다. 예를 들어, "연속적 핵염기"는 서열에서 서로에 바로 인접한 핵염기를 의미한다.
본 명세서에 사용된 바와 같이, "구속된 에틸" 또는 "cEt" 또는 "cEt 변형된당"은 이환형 당의 제2 고리가 β-D 리보실 당 모이어티의 4'-탄소 및 2'-탄소를 연결하는 브릿지를 통해 형성되는 β-D 리보실 이환형 당 모이어티를 의미하고, 여기서 상기 브릿지는 식 4'-CH(CH3)-O-2'를 갖고, 상기 브릿지의 메틸기는 S 배치형태이다.
본 명세서에 사용된 바와 같이, "cEt 뉴클레오사이드"는 cEt 변형된 당을 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "키랄 풍부 집단"은 동일한 분자식의 복수의 분자를 의미하고, 여기서 특정 키랄 중심에 특정 입체화학적 배치형태를 함유하는 집단 내에서 분자의 수 또는 백분율은 특정 키랄 중심이 스테레오랜덤이면 집단 내에서 동일한 특정 키랄 중심에 동일한 특정 입체화학적 배치형태를 함유할 것으로 기대된 분자의 수 또는 백분율 초과이다. 각 분자 내에서 다중 키랄 중심을 가지고 있는 분자의 키랄 풍부 집단은 하나 이상의 스테레오랜덤 키랄 중심을 함유할 수 있다. 특정 구현예에서, 분자는 변형된 올리고뉴클레오타이드이다. 특정 구현예에서, 분자는 변형된 올리고뉴클레오타이드를 포함하는 화합물이다.
본 명세서에 사용된 바와 같이, "갭머"는 하나 이상의 뉴클레오사이드를 가지고 있는 외부 영역 사이 위치한 RNase H 절단을 지원하는 복수의 뉴클레오사이드를 가지고 있는 내부 영역을 포함하는 변형된 올리고뉴클레오타이드를 의미하고, 여기서 내부 영역을 포함하는 뉴클레오사이드는 외부 영역을 포함하는 뉴클레오사이드 또는 뉴클레오사이드들과 화학적으로 구별된다. 내부 영역은 "갭"으로서 지칭될 수 있고 외부 영역은 "윙"으로서 지칭될 수 있다. 달리 나타내지 않는 한, "갭머"는 당 모티프를 지칭한다. 달리 나타내지 않는 한, 갭머의 갭의 뉴클레오사이드의 당 모이어티는 미변형된 2'-데옥시리보실이다. 따라서, 용어 "MOE 갭머"는 2'-데옥시뉴클레오사이드의 양쪽 윙 및 갭에서 2'-MOE 뉴클레오사이드의 당 모티프를 가지고 있는 갭머를 나타낸다. 달리 나타내지 않는 한, MOE 갭머는 하나 이상의 변형된 인터뉴클레오사이드 연결기 및/또는 변형된 핵염기를 포함할 수 있고 그와 같은 변형은 당 변형의 갭머 패턴을 반드시 따르지 않는다.
본 명세서에 사용된 바와 같이, "핫스팟 영역"은 표적 핵산의 양 또는 활성의 올리고머성 화합물-매개된 감소를 할 수 있는 표적 핵산 상에서 핵염기의 범위이다.
본 명세서에 사용된 바와 같이, "하이브리드화"는 상보성 올리고뉴클레오타이드 및/또는 핵산의 짝짓기 또는 어닐링을 의미한다. 특정 기전에 제한되지 않으면서, 하이브리드화의 가장 흔한 기전은, 상보성 핵염기 사이, 왓슨-크릭, 휴그스틴 또는 역전된 휴그스틴 수소 결합일 수 있는, 수소 결합을 포함한다.
본 명세서에 사용된 바와 같이, 용어 "인터뉴클레오사이드 연결기"는 올리고뉴클레오타이드에서 인접한 뉴클레오사이드 사이 공유 연결기이다. 본 명세서에 사용된 바와 같이 "변형된 인터뉴클레오사이드 연결기"는 포스포디에스테르 인터뉴클레오사이드 연결기 이외 임의의 인터뉴클레오사이드 연결기를 의미한다. "포스포로티오에이트 인터뉴클레오사이드 연결기"는 포스포디에스테르 인터뉴클레오사이드 연결기의 비-브릿징 산소 원자들 중 1개가 황 원자로 대체되는 변형된 인터뉴클레오사이드 연결기이다.
본 명세서에 사용된 바와 같이, "링커-뉴클레오사이드"는, 어느 한쪽 직접적으로 또는 간접적으로, 올리고뉴클레오타이드를 컨쥬게이트 모이어티에 연결시키는 뉴클레오사이드를 의미한다. 링커-뉴클레오사이드는 올리고머성 화합물의 컨쥬게이트 링커 내에서 위치한다. 링커-뉴클레오사이드는 이들이 올리고뉴클레오타이드로 연속적일지라도 올리고머성 화합물의 올리고뉴클레오타이드 부분의 일부로 간주되지 않는다.
본 명세서에 사용된 바와 같이, "비-이환형 변형된 당 모이어티"는, 제2 고리를 형성하기 위해 당의 2개 원자 사이 브릿지를 형성하지 않는, 변형, 예컨대 치환체를 포함하는 변형된 당 모이어티를 의미한다.
본 명세서에 사용된 바와 같이, "미스매치" 또는 "비-상보성"은 제1 및 제2 올리고뉴클레오타이드가 정렬되는 경우 제2 올리고뉴클레오타이드 또는 표적 핵산의 상응하는 핵염기와 상보성이지 않은 제1 올리고뉴클레오타이드의 핵염기를 의미한다.
본 명세서에 사용된 바와 같이, "MOE"는 메톡시에틸을 의미한다. "2'-MOE" 또는 "2'-MOE 변형된 당"은 리보실 당 모이어티의 2'-OH 기 대신에 2'-OCH2CH2OCH3 기를 의미한다. 본 명세서에 사용된 바와 같이, "2'-MOE 뉴클레오사이드"는 2'-MOE 변형된 당을 포함하는 뉴클레오사이드를 의미한다.
본 명세서에 사용된 바와 같이, "모티프"는 올리고뉴클레오타이드에서 미변형된 및/또는 변형된 당 모이어티, 핵염기, 및/또는 인터뉴클레오사이드 연결기의 패턴을 의미한다.
본 명세서에 사용된 바와 같이, "RNA"는 달리 특정되지 않는 한 pre-mRNA 및 성숙 mRNA를 포함하는 그리고 단백질을 인코딩하는 RNA 전사체를 의미한다.
본 명세서에 사용된 바와 같이, "신경퇴행성 질환"은, 운동 기능의 소실 및 뉴런의 사망을 포함하는, 기능 또는 구조의 진행형 소실에 의해 표시된 병태를 의미한다. 특정 구현예에서, 신경퇴행성 질환은 파킨슨병이다. 특정 구현예에서, 파킨슨병은 LRRK2 매개된 파킨슨병 또는 비-LRRK2 매개된 파킨슨병일 수 있다.
"비-LRRK2 매개된 파킨슨병"은 원인성 LRRK2 유전적 돌연변이와 연관되지 않은 파킨슨병의 진단이다. 원인성 LRRK2 유전적 돌연변이는 G2019S, R1441C, R1441G, I2020T, 및 Y1699C를 포함한다. 파킨슨병의 진단은 개체의 의료 이력 평가, 징후 및 증상의 관찰, 및 표준 임상 시험 또는 평가를 포함하는 임의의 방법에 의해 달성될 수 있다. LRRK2와 연관된 돌연변이, 예컨대 G2019S, R1441C, R1441G, I2020T, 및 Y1699C에 대한 유전 시험은 개체가 비-LRRK2 매개된 파킨슨병을 가지고 있는지 여부를 밝혀낼 수 있다. 파킨슨병의 진단을 가지고 있는, 그러나 원인성 LRRK2 돌연변이가 없는 개체는 비-LRRK2 매개된 파킨슨병을 가지고 있다. "비-LRRK2 매개된 파킨슨병을 가지고 있는 동물의 확인"은 파킨슨병으로 진단된 또는 원인성 LRRK2 돌연변이 없이 파킨슨병을 발병할 것으로 예고된 동물을 확인하는 것을 의미한다.
본 명세서에 사용된 바와 같이, "핵염기"는 미변형된 핵염기 또는 변형된 핵염기를 의미한다. 본 명세서에 사용된 바와 같이 "미변형된 핵염기"는 아데닌 (A), 티민 (T), 시토신 (C), 우라실 (U), 또는 구아닌 (G)이다. 본 명세서에 사용된 바와 같이, "변형된 핵염기"는 적어도 하나의 미변형된 핵염기와 짝짓기할 수 있는 미변형된 A, T, C, U, 또는 G 이외 원자의 그룹이다. "5-메틸 시토신"은 변형된 핵염기이다. 보편적인 염기는 5개의 미변형된 핵염기들 중 어느 하나와 짝짓기할 수 있는 변형된 핵염기이다. 본 명세서에 사용된 바와 같이, "핵염기 서열"은 임의의 당 또는 인터뉴클레오사이드 연결기 변형과 독립적인 핵산 또는 올리고뉴클레오타이드에서 연속적 핵염기의 순서를 의미한다.
본 명세서에 사용된 바와 같이, "뉴클레오사이드"는 핵염기 및 당 모이어티를 포함하는 화합물을 의미한다. 핵염기 및 당 모이어티 각각은, 독립적으로, 미변형되거나 변형된다. 본 명세서에 사용된 바와 같이, "변형된 뉴클레오사이드"는 변형된 핵염기 및/또는 변형된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 변형된 뉴클레오사이드는, 핵염기가 부족한, 무염기성 뉴클레오사이드를 포함한다. "연결된 뉴클레오사이드"는 연속적 서열에서 연결되는 뉴클레오사이드이다 (즉 추가의 뉴클레오사이드는 연결되는 것들 사이에서 존재하지 않는다).
본 명세서에 사용된 바와 같이, "올리고머성 화합물"은 올리고뉴클레오타이드 및 선택적으로 하나 이상의 추가의 특징, 예컨대 컨쥬게이트 그룹 또는 말단기를 의미한다. 올리고머성 화합물은 제1 올리고머성 화합물에 상보성인 제2 올리고머성 화합물과 짝짓기될 수 있거나 짝짓기되지 않을 수 있다. "단일가닥 올리고머성 화합물"은 짝짓기되지 않은 올리고머성 화합물이다. 용어 "올리고머성 듀플렉스"는 상보성 핵염기 서열을 가지고 있는 2개의 올리고머성 화합물에 의해 형성된 듀플렉스를 의미한다. 올리고머성 듀플렉스의 각 올리고머성 화합물은 "듀플렉스된 올리고머성 화합물"로서 지칭될 수 있다.
본 명세서에 사용된 바와 같이, "올리고뉴클레오타이드"는 인터뉴클레오사이드 연결기를 통해 연결된 결합 뉴클레오사이드의 가닥을 의미하고, 상기 각 뉴클레오사이드 및 인터뉴클레오사이드 연결기는 변형될 수 있거나 미변형될 수 있다. 달리 나타내지 않는 한, 올리고뉴클레오타이드는 8-50개의 연결된 뉴클레오사이드로 이루어진다. 본 명세서에 사용된 바와 같이, "변형된 올리고뉴클레오타이드"는 올리고뉴클레오타이드를 의미하고, 상기 적어도 하나의 뉴클레오사이드 또는 인터뉴클레오사이드 연결기는 변형된다. 본 명세서에 사용된 바와 같이, "미변형된 올리고뉴클레오타이드"는 임의의 뉴클레오사이드 변형 또는 인터뉴클레오사이드 변형을 포함하지 않는 올리고뉴클레오타이드를 의미한다.
본 명세서에 사용된 바와 같이, "약제학적으로 허용가능한 담체 또는 희석제"는 동물에 투여하기에 있어서 사용에 적당한 임의의 서브스턴스를 의미한다. 특정 상기 담체는 약제학적 조성물이, 예를 들어, 대상체에 의한 경구 섭취를 위하여 정제, 알약, 당의정, 캡슐, 액체, 겔, 시럽, 슬러리, 현탁액 및 로젠지로서 제형화되게 할 수 있다. 특정 구현예에서, 약제학적으로 허용가능한 담체 또는 희석제는 멸균수, 멸균 염수, 멸균 완충 용액 또는 멸균 인공 뇌척수액이다.
본 명세서에 사용된 바와 같이 "약제학적으로 허용가능한 염"은 화합물의 생리적으로 및 약제학적으로 허용가능한 염을 의미한다. 약제학적으로 허용가능한 염은 모 화합물의 원하는 생물학적 활성을 보유하고 거기에 원하지 않는 독물학적 효과를 부여하지 않는다.
본 명세서에 사용된 바와 같이 "약제학적 조성물"은 대상체에게 투여하기에 적당한 서브스턴스의 혼합물을 의미한다. 예를 들어, 약제학적 조성물은 올리고머성 화합물 및 멸균 수용액을 포함할 수 있다. 특정 구현예에서, 약제학적 조성물은 특정 세포주내 자유 흡수 검정에서 활성을 보여준다.
본 명세서에 사용된 바와 같이 "전구약물"은 동물 또는 이의 세포 내에서 상이한 형태로 전환되는 바디 외부에서 형태로의 치료적 제제를 의미한다. 전형적으로 동물 내에서 전구약물의 전환은 세포 또는 조직에서 존재하는 효소 (예를 들면, 내인성 또는 바이러스 효소) 또는 화학물질의 작용에 의해 및/또는 생리적 조건에 의해 촉진된다.
본 명세서에 사용된 바와 같이, "양 또는 활성 감소 또는 억제"는 미처리된 또는 대조군 샘플내 전사적 발현 또는 활성에 비하여 전사적 발현 또는 활성의 감소 또는 봉쇄를 지칭하고 전사적 발현 또는 활성의 총 제거를 반드시 나타내지 않는다.
본 명세서에 사용된 바와 같이, "RNAi 화합물"은, 적어도 부분적으로, RISC 또는 Ago2를 통해 작용하여 표적 핵산 및/또는 표적 핵산에 의해 인코딩된 단백질을 조절하는 안티센스 화합물을 의미한다. RNAi 화합물은, 비제한적으로 이중가닥 siRNA, 단일가닥 RNA (ssRNA), 및 마이크로RNA 모방체를 포함하는, 마이크로RNA를 포함한다. 특정 구현예에서, RNAi 화합물은 표적 핵산의 양, 활성, 및/또는 스플라이싱을 조절한다. 용어 RNAi 화합물은 RNase H를 통해 작용하는 안티센스 화합물을 배제한다.
본 명세서에 사용된 바와 같이, 올리고뉴클레오타이드와 관련하여 "자기-상보성"은 자체에 적어도 부분적으로 하이브리드화하는 올리고뉴클레오타이드를 의미한다.
본 명세서에 사용된 바와 같이, "siRNA"는 2개의 역-평행 및 실질적으로 상보성 핵산 가닥을 포함하는 듀플렉스 구조를 가지고 있는 리보핵산 분자를 지칭한다. 듀플렉스 구조를 형성하는 2개의 가닥은 1개의 대형 RNA 분자의 상이한 부분일 수 있거나, 이들은 별도 RNA 분자일 수 있다. 2개의 가닥이 1개의 대형 분자의 일부이고, 그러므로 듀플렉스 구조를 형성하는 1개 가닥의 3'-말단과 각각의 다른 가닥의 5' 말단 사이 연속적 핵염기에 의해 연결되는 경우, 연결하는 RNA 사슬은 "헤어핀 루프"로서 지칭된다. RNA 가닥은 뉴클레오타이드의 동일한 또는 상이한 수를 가질 수 있다.
본 명세서에 사용된 바와 같이, "표준 세포 검정"은 실시예 4에서 기재된 검정 및 이의 합리적인 변동을 의미한다.
본 명세서에 사용된 바와 같이, "표준 생체내 검정"은 실시예 14에서 기재된 실험, 및 이의 합리적인 변동을 의미한다.
본 명세서에 사용된 바와 같이, 동일한 분자식의 분자의 집단의 맥락에서 "스테레오랜덤 키랄 중심"은 랜덤 입체화학적 배치형태를 가지고 있는 키랄 중심을 의미한다. 예를 들어, 스테레오랜덤 키랄 중심을 포함하는 분자의 집단에서, 스테레오랜덤 키랄 중심의 (S) 배치형태를 가지고 있는 분자의 수는 스테레오랜덤 키랄 중심의 (R) 배치형태를 가지고 있는 분자의 수일 수 있지만 반드시 동일하지 않다. 키랄 중심의 입체화학적 배치형태는 입체화학적 배치형태를 제어하기 위해 설계되지 않은 합성 방법의 결과인 경우 랜덤으로 간주된다. 특정 구현예에서, 스테레오랜덤 키랄 중심은 스테레오랜덤 포스포로티오에이트 인터뉴클레오사이드 연결기이다.
본 명세서에 사용된 바와 같이, "당 모이어티"는 미변형된 당 모이어티 또는 변형된 당 모이어티를 의미한다. 본 명세서에 사용된 바와 같이, "미변형된 당 모이어티"는, RNA에서 발견된 대로 2'-OH(H) 리보실 모이어티 ("미변형된 RNA 당 모이어티"), 또는 DNA에서 발견된 대로, 2'-H(H) 데옥시리보실 모이어티 ("미변형된 DNA 당 모이어티")를 의미한다. 미변형된 당 모이어티는 1', 3', 및 4' 위치의 각각에 1개의 수소, 3' 위치에 산소, 및 5' 위치에 2개의 수소를 갖는다. 본 명세서에 사용된 바와 같이, "변형된 당 모이어티" 또는 "변형된 당"은 변형된 푸라노실 당 모이어티 또는 당 대리물을 의미한다.
본 명세서에 사용된 바와 같이, "당 대리물"은 올리고뉴클레오타이드에서 핵염기를 또 다른 그룹, 예컨대 인터뉴클레오사이드 연결기, 컨쥬게이트 그룹, 또는 말단기에 결합시킬 수 있는 푸라노실 모이어티 이외를 가지고 있는 변형된 당 모이어티를 의미한다. 당 대리물을 포함하는 변형된 뉴클레오사이드는 올리고뉴클레오타이드 내에서 하나 이상의 위치 속에 편입될 수 있고 그와 같은 올리고뉴클레오타이드는 상보성 올리고머성 화합물 또는 표적 핵산에 하이브리드화할 수 있다.
본 명세서에 사용된 바와 같이, "표적 핵산" 및 "표적 RNA"는 안티센스 화합물이 작용하도록 설계되는 핵산을 의미한다.
본 명세서에 사용된 바와 같이, "표적 영역"은 올리고머성 화합물이 하이브리드화하도록 설계되는 표적 핵산의 일 부분을 의미한다.
본 명세서에 사용된 바와 같이, "말단기"는 올리고뉴클레오타이드의 말단에 공유적으로 연결되는 원자의 그룹 또는 화학기를 의미한다.
본 명세서에 사용된 바와 같이, "치료적 유효량"은 동물에게 치료적 이점을 제공하는 약제학적 제제의 양을 의미한다. 예를 들어, 치료적 유효량은 질환의 증상을 개선한다.
특정 구현예
본 개시내용은 하기 비제한 번호로 매겨진 구현예를 제공한다:
구현예 1. 12 내지 50개의 연결된 뉴클레오사이드로 이루어지는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물이며, 상기 변형된 올리고뉴클레오타이드의 핵염기 서열이 LRRK2 핵산의 동일 길이 부분에 적어도 90% 상보성이고, 상기 변형된 올리고뉴클레오타이드가 변형된 당, 당 대리물, 및 변형된 인터뉴클레오사이드 연결기로부터 선택된 적어도 하나의 변형을 포함하는, 올리고머성 화합물.
구현예 2: 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고 서열번호: 30-3847의 핵염기 서열 중 임의의 것의 적어도 12, 적어도 13, 적어도 14, 적어도 15, 적어도 16, 적어도 17, 적어도 18, 적어도 19, 또는 적어도 20개의 연속적 핵염기를 포함하는 핵염기 서열을 가지고 있는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물.
구현예 3: 12 내지 50개의 연결된 뉴클레오사이드로 이루어지고 적어도 8, 적어도 9, 적어도 10, 적어도 11, 적어도 12, 적어도 13, 적어도 14, 적어도 15, 적어도 16, 적어도 17, 적어도 18, 적어도 19, 또는 적어도 20개의 연속적 핵염기의 부분을 포함하는 핵염기 서열을 가지고 있는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물이며, 상기 부분이 하기에 상보성인, 올리고머성 화합물:
서열번호: 2의 핵염기 18,633-18,658의 동일 길이 부분;
서열번호: 2의 핵염기 21,721-21,755의 동일 길이 부분;
서열번호: 2의 핵염기 27,963-28,016의 동일 길이 부분;
서열번호: 2의 핵염기 35,415-35,446의 동일 길이 부분;
서열번호: 2의 핵염기 77,221-77,264의 동일 길이 부분;
서열번호: 2의 핵염기 81,581-81,612 및/또는 87,838-87,869의 동일 길이 부분;
서열번호: 2의 핵염기 81,627-81,651의 동일 길이 부분;
서열번호: 2의 핵염기 82,058-82,081의 동일 길이 부분;
서열번호: 2의핵염기 82,180-82,220의 동일 길이 부분;
서열번호: 2의 핵염기 82,500-82,525의 동일 길이 부분;
서열번호: 2의 핵염기 91,038-91,067의 동일 길이 부분;
서열번호: 2의 핵염기 92,148-92,173의 동일 길이 부분;
서열번호: 2의 핵염기 98,186-98,220의 동일 길이 부분;
서열번호: 2의 핵염기 98,218-98,242의 동일 길이 부분;
서열번호: 2의 핵염기 99,199-99,223의 동일 길이 부분;
서열번호: 2의 핵염기 119,903-119,936의 동일 길이 부분; 또는
서열번호: 1의 핵염기 4,062-4,086의 동일 길이 부분.
구현예 4. 구현예 1-3 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가, 변형된 올리고뉴클레오타이드의 전체 핵염기 서열에 걸쳐서 측정된 경우, 서열번호: 1 또는 서열번호: 2의 핵염기 서열에 적어도 80%, 85%, 90%, 95%, 또는 100% 상보성인 핵염기 서열을 가지고 있는, 올리고머성 화합물.
구현예 5. 구현예 1-4 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 6. 구현예 5에 있어서, 변형된 올리고뉴클레오타이드가 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 7. 구현예 6에 있어서, 변형된 올리고뉴클레오타이드가 이환형 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 8. 구현예 7에 있어서, 변형된 올리고뉴클레오타이드가 2'-4' 브릿지를 가지고 있는 이환형 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하며, 상기 2'-4' 브릿지가 -O-CH2-; 및 -O-CH(CH3)-로부터 선택되는, 올리고머성 화합물.
구현예 9. 구현예 5-8 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 비-이환형 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 10. 구현예 9에 있어서, 변형된 올리고뉴클레오타이드가 2'-MOE 변형된 당 또는 2'-OMe 변형된 당을 포함하는 비-이환형 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 11. 구현예 5-10 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 당 대리물을 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 12. 구현예 11에 있어서, 변형된 올리고뉴클레오타이드가 모폴리노 및 PNA로부터 선택된 당 대리물을 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 13. 구현예 1-12 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 하기를 포함하는 당 모티프를 가지며:
1-5개의 연결된 5'-영역 뉴클레오사이드로 이루어지는 5'-영역;
6-10개의 연결된 중심 영역 뉴클레오사이드로 이루어지는 중심 영역; 및
1-5개의 연결된 3'-영역 뉴클레오사이드로 이루어지는 3'-영역;
각각의 상기 5'-영역 뉴클레오사이드 및 각각의 상기 3'-영역 뉴클레오사이드가 변형된 당 모이어티를 포함하고 각각의 상기 중심 영역 뉴클레오사이드가 미변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머성 화합물.
구현예 14. 구현예 1-13 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 인터뉴클레오사이드 연결기를 포함하는, 올리고머성 화합물.
구현예 15. 구현예 14에 있어서, 변형된 올리고뉴클레오타이드의 각 인터뉴클레오사이드 연결기가 변형된 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
구현예 16. 구현예 14 또는 15에 있어서, 적어도 하나의 인터뉴클레오사이드 연결기가 포스포로티오에이트 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
구현예 17. 구현예 14 또는 16에 있어서, 변형된 올리고뉴클레오타이드가 적어도 하나의 포스포디에스테르 인터뉴클레오사이드 연결기를 포함하는, 올리고머성 화합물.
구현예 18. 구현예 14, 16, 또는 17 중 어느 하나에 있어서, 각 인터뉴클레오사이드 연결기가 포스포디에스테르 인터뉴클레오사이드 연결기 또는 포스포로티오에이트 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
구현예 19. 구현예 1-18 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는, 올리고머성 화합물.
구현예 20. 구현예 19에 있어서, 변형된 핵염기가 5-메틸 시토신인, 올리고머성 화합물.
구현예 21. 구현예 1-20 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 12-30, 12-22, 12-20, 14-20, 15-25, 16-20, 18-22 또는 18-20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머성 화합물.
구현예 22. 구현예 1-21 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드가 17 또는 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머성 화합물.
구현예 23. 구현예 1-22 중 어느 하나에 있어서, 변형된 올리고뉴클레오타이드로 이루어지는 올리고머성 화합물.
구현예 24. 구현예 1-22 중 어느 하나에 있어서, 컨쥬게이트 모이어티 및 컨쥬게이트 링커를 포함하는 컨쥬게이트 그룹을 포함하는 올리고머성 화합물.
구현예 25. 구현예 24에 있어서, 컨쥬게이트 그룹이 1-3개의 GalNAc 리간드를 포함하는 GalNAc 클러스터를 포함하는, 올리고머성 화합물.
구현예 26. 구현예 24 또는 25에 있어서, 컨쥬게이트 링커가 단일 결합으로 이루어지는, 올리고머성 화합물.
구현예 27. 구현예 25에 있어서, 컨쥬게이트 링커가 절단가능한, 올리고머성 화합물.
구현예 28. 구현예 27에 있어서, 컨쥬게이트 링커가 1-3개의 링커-뉴클레오사이드를 포함하는, 올리고머성 화합물.
구현예 29. 구현예 24-28 중 어느 하나에 있어서, 컨쥬게이트 그룹이 변형된 올리고뉴클레오타이드의 5'-말단에서 변형된 올리고뉴클레오타이드에 부착되는, 올리고머성 화합물.
구현예 30. 구현예 24-28 중 어느 하나에 있어서, 컨쥬게이트 그룹이 변형된 올리고뉴클레오타이드의 3'-말단에서 변형된 올리고뉴클레오타이드에 부착되는, 올리고머성 화합물.
구현예 31. 구현예 1-30 중 어느 하나에 있어서, 말단기를 포함하는 올리고머성 화합물.
구현예 32. 구현예 1-31 중 어느 하나에 있어서, 단일가닥 올리고머성 화합물인 올리고머성 화합물.
구현예 33. 구현예 1-27 또는 29-31 중 어느 하나에 있어서, 링커-뉴클레오사이드를 포함하지 않는 올리고머성 화합물.
구현예 34. 구현예 1-31 또는 33 중 어느 하나에 따른 올리고머성 화합물을 포함하는 올리고머성 듀플렉스.
구현예 35. 구현예 1-33 중 어느 하나에 따른 올리고머성 화합물 또는 구현예 34에 따른 올리고머성 듀플렉스를 포함하거나 또는 이로 이루어지는 안티센스 화합물.
구현예 36. 구현예 1-33 중 어느 하나에 따른 올리고머성 화합물 또는 구현예 34에 따른 올리고머성 듀플렉스, 및 약제학적으로 허용가능한 담체 또는 희석제를 포함하는 약제학적 조성물.
구현예 37. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 222)
또는 이의 염.
구현예 38. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 888)
또는 이의 염.
구현예 39. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 1431)
또는 이의 염.
구현예 40. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3590)
또는 이의 염.
구현예 41. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3385)
또는 이의 염.
구현예 42. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 852)
또는 이의 염.
구현예 43. 구현예 37-42 중 어느 하나에 있어서, 상기 식의 나트륨염인, 변형된 올리고뉴클레오타이드.
구현예 44. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 222).
구현예 45. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 888).
구현예 46. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 1431).
구현예 47. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3590).
구현예 48. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3385).
구현예 49. 하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 852).
구현예 50. 구현예 37-49 중 어느 하나에 따른 변형된 올리고뉴클레오타이드의 키랄 풍부 집단이며, 특정 입체화학적 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 51. 구현예 50에 있어서, (Sp) 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 52. 구현예 50 또는 51에 있어서, (Rp) 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 53. 구현예 50에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 특정, 독립적으로 선택된 입체화학적 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 54. 구현예 53에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 (Sp) 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 55. 구현예 53에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 (Rp) 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 56. 구현예 50 또는 구현예 53에 있어서, 5'에서 3' 방향으로, Sp-Sp-Rp 배치형태의 적어도 3개의 연속적 포스포로티오에이트 인터뉴클레오사이드 연결기를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
구현예 57. 구현예 37-49 중 어느 하나에 따른 변형된 올리고뉴클레오타이드의 집단이며, 변형된 올리고뉴클레오타이드의 포스포로티오에이트 인터뉴클레오사이드 연결기의 모두가 스테레오랜덤인, 집단.
구현예 58. 구현예 37-49 중 어느 하나에 따른 변형된 올리고뉴클레오타이드 및 약제학적으로 허용가능한 희석제 또는 담체를 포함하는 약제학적 조성물.
구현예 59. 구현예 58에 있어서, 약제학적으로 허용가능한 희석제가 인공 뇌척수액인, 약제학적 조성물.
구현예 60. 구현예 59에 있어서, 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 본질적으로 이루어지는 약제학적 조성물.
구현예 61. 구현예 36 또는 58 내지 60 중 어느 하나에 따른 약제학적 조성물을 동물에 투여하는 단계를 포함하는 방법.
구현예 62. 구현예 36 또는 58 내지 60 중 어느 하나에 따른 약제학적 조성물의 치료적 유효량을 LRRK2와 연관된 질환을 가지고 있거나 발병의 위험에 처한 개체에 투여하는 단계; 및 그것에 의해 LRRK2와 연관된 질환을 치료하는 단계를 포함하는, LRRK2와 연관된 질환의 치료 방법.
구현예 63. 구현예 62에 있어서, LRRK2와 연관된 질환이 신경퇴행성 질환인, 방법.
구현예 64. 구현예 63에 있어서, 신경퇴행성 질환이 파킨슨병인, 방법.
구현예 65. 구현예 64에 있어서, 신경퇴행성 질환의 적어도 하나의 징후 또는 특징이 개선되는, 방법.
구현예 66. 구현예 65에 있어서, 징후 또는 특징이 운동실조증, 신경병증, 및 응집체 형성 중 임의의 것인 방법.
구현예 67. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Ges mCeo Teo mCeo Aes Tds Ads Tds mCds Tds Ads Ads Ads Gds Ads mCeo mCeo Ges mCes Ae (서열번호: 222); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 68. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Tes mCeo Aeo mCeo mCes Ads mCds Ads Ads Ads mCds Tds mCds Ads Tds Geo Geo Aes mCes Te (서열번호: 888); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 69. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Aes mCeo mCeo mCeo Tes Tds Tds mCds mCds Ads Tds Gds Tds Gds Ads Aeo mCeo Aes Tes Te (서열번호: 1431); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 70. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Aes mCeo Geo mCeo Aes mCds Tds Tds Ads Ads mCds Ads Ads Tds Ads Teo mCeo Aes Tes Ae (서열번호: 3590); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 71. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Geo mCeo Aeo Aes Tds mCds Ads Tds Tds Gds Gds Tds Ads Gds mCeo Aeo Tes Aes mCe (서열번호: 3385); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 72. 하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: mCes Geo mCes Aes mCes Tds Tds Ads Ads mCds Ads Ads Tds Ads Tds mCes Aeo Tes Aes Te (서열번호: 852); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
구현예 73. 구현예 3에 있어서, 변형된 올리고뉴클레오타이드가 RNAi 화합물인, 올리고머성 화합물.
구현예 74. 구현예 73 항에 있어서, RNAi 화합물이 ssRNA 또는 siRNA인, 올리고머성 화합물.
I.
특정 올리고뉴클레오타이드
특정 구현예에서, 연결된 뉴클레오사이드로 이루어지는, 올리고뉴클레오타이드를 포함하는 올리고머성 화합물은 본 명세서에 제공된다. 올리고뉴클레오타이드는 미변형된 올리고뉴클레오타이드 (RNA 또는 DNA)일 수 있거나 변형된 올리고뉴클레오타이드일 수 있다. 변형된 올리고뉴클레오타이드는 미변형된 RNA 또는 DNA에 비하여 적어도 하나의 변형을 포함한다. 즉, 변형된 올리고뉴클레오타이드는 (변형된 당 모이어티 및/또는 변형된 핵염기를 포함하는) 적어도 하나의 변형된 뉴클레오사이드 및/또는 적어도 하나의 변형된 인터뉴클레오사이드 연결기를 포함한다.
A.
특정 변형된 뉴클레오사이드
변형된 뉴클레오사이드는 변형된 당 모이어티 또는 변형된 핵염기 또는 당 모이어티 및 변형된 핵염기 둘 모두를 포함한다.
1.
특정 당 모이어티
특정 구현예에서, 변형된 당 모이어티는 비-이환형 변형된 당 모이어티이다. 특정 구현예에서, 변형된 당 모이어티는 이환형 또는 삼환형 당 모이어티이다. 특정 구현예에서, 변형된 당 모이어티는 당 대리물이다. 그와 같은 당 대리물은 변형된 당 모이어티의 다른 유형의 것에 상응하는 하나 이상의 치환을 포함할 수 있다.
특정 구현예에서, 변형된 당 모이어티는 이환형 구조를 형성하기 위해 푸라노실 고리의 2개의 원자를 브릿징하지 않는 하나 이상의 치환기를 가진 푸라노실 고리를 포함하는 비-이환형 변형된 당 모이어티이다. 그와 같은 비 브릿징 치환체는, 비제한적으로 2', 4', 및/또는 5' 위치에서 치환체를 포함하는, 푸라노실의 임의의 위치에 있을 수 있다. 특정 구현예에서 비-이환형 변형된 당 모이어티의 하나 이상의 비-브릿징 치환체는 분지형이다. 비-이환형 변형된 당 모이어티에 적당한 2'-치환기의 예는 하기를 비제한적으로 포함한다: 2'-F, 2'-OCH3 ("OMe" 또는 "O-메틸"), 및 2'-O(CH2)2OCH3 ("MOE"). 특정 구현예에서, 2'-치환기는 하기중으로부터 선택된다: 할로, 알릴, 아미노, 아지도, SH, CN, OCN, CF3, OCF3, O-C1-C10 알콕시, O-C1-C10 치환된 알콕시, O-C1-C10 알킬, O-C1-C10 치환된 알킬, S-알킬, N(Rm)-알킬, O-알케닐, S-알케닐, N(Rm)-알케닐, O-알키닐, S-알키닐, N(Rm)-알키닐, O-알킬레닐-O-알킬, 알키닐, 알크아릴, 아르알킬, O-알크아릴, O-아르알킬, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn) 또는 OCH2C(=O)-N(Rm)(Rn), 여기에서 각 Rm 및 Rn은, 독립적으로, Cook 등, U.S. 6,531,584; Cook 등, U.S. 5,859,221; 및 Cook 등, U.S. 6,005,087에서 기재된 H, 아미노 보호기, 또는 치환된 또는 미치환된 C1-C10 알킬, 및 2'-치환기임. 이들 2'-치환기의 특정 구현예는 독립적으로 하기중으로부터 선택된 하나 이상의 치환기로 추가로 치환될 수 있다: 하이드록실, 아미노, 알콕시, 카복시, 벤질, 페닐, 니트로 (NO2), 티올, 티오알콕시, 티오알킬, 할로겐, 알킬, 아릴, 알케닐 및 알키닐. 비-이환형 변형된 당 모이어티에 적당한 4'-치환기의 예는 비제한적으로 알콕시 (예를 들면, 메톡시), 알킬, 및 Manoharan 등, WO 2015/106128에서 기재된 것을 포함한다. 비-이환형 변형된 당 모이어티에 적당한 5'-치환기의 예는 하기를 비제한적으로 포함한다: 5-메틸 (R 또는 S), 5'-비닐, 및 5'-메톡시. 특정 구현예에서, 비-이환형 변형된 당 모이어티는 1개 초과 비-브릿징 당 치환체, 예를 들어, 2'-F-5'-메틸 당 모이어티 및 변형된 당 모이어티 그리고 Migawa 등, WO 2008/101157 및 Rajeev 등, US2013/0203836에서 기재된 변형된 뉴클레오사이드를 포함한다.).
특정 구현예에서, 2'-치환된 비-이환형 변형된 뉴클레오사이드는 하기로부터 선택된 비-브릿징 2'-치환기를 포함하는 당 모이어티를 포함한다: F, NH2, N3, OCF3, OCH3, O(CH2)3NH2, CH2CH=CH2, OCH2CH=CH2, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn), O(CH2)2O(CH2)2N(CH3)2, 및 N-치환된 아세트아미드 (OCH2C(=O)-N(Rm)(Rn)), 여기에서 각 Rm 및 Rn은, 독립적으로, H, 아미노 보호기, 또는 치환된 또는 미치환된 C1-C10 알킬임.
특정 구현예에서, 2'-치환된 뉴클레오사이드 비-이환형 변형된 뉴클레오사이드는 하기로부터 선택된 비-브릿징 2'-치환기를 포함하는 당 모이어티를 포함한다: F, OCF3, OCH3, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(CH3)2, O(CH2)2O(CH2)2N(CH3)2, 및 OCH2C(=O)-N(H)CH3 ("NMA").
특정 구현예에서, 2'-치환된 뉴클레오사이드 비-이환형 변형된 뉴클레오사이드는 하기로부터 선택된 비-브릿징 2'-치환기를 포함하는 당 모이어티를 포함한다: F, OCH3, 및 OCH2CH2OCH3.
특정 모디페드 당 모이어티는, 이환형 당 모이어티를 초래하는, 제2 고리를 형성하기 위해 푸라노실 고리의 2개의 원자를 브릿징하는 치환체를 포함한다. 특정 상기 구현예에서, 이환형 당 모이어티는 4' 및 2' 푸라노스 고리 원자 사이 브릿지를 포함한다. 그와 같은 4' 내지 2' 브릿징 당 치환체의 예는 하기를 비제한적으로 포함한다: 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2' ("LNA"), 4'-CH2-S-2', 4'-(CH2)2-O-2' ("ENA"), 4'-CH(CH3)-O-2' ("구속된 에틸" 또는 "cEt"로 칭함), 4'-CH2-O-CH2-2', 4'-CH2-N(R)-2', 4'-CH(CH2OCH3)-O-2' ("구속된 MOE" 또는 "cMOE") 및 이의 유사체 (참고, 예를 들면, Seth 등, U.S. 7,399,845, Bhat 등, U.S. 7,569,686, Swayze 등, U.S. 7,741,457, 및 Swayze 등, U.S. 8,022,193), 4'-C(CH3)(CH3)-O-2' 및 이의 유사체 (참고, 예를 들면, Seth 등, U.S. 8,278,283), 4'-CH2-N(OCH3)-2' 및 이의 유사체 (참고, 예를 들면, Prakash 등, U.S. 8,278,425), 4'-CH2-O-N(CH3)-2' (참고, 예를 들면, Allerson 등, U.S. 7,696,345 및 Allerson 등, U.S. 8,124,745), 4'-CH2-C(H)(CH3)-2' (참고, 예를 들면, Zhou, 등, J. Org.Chem., 2009, 74, 118-134), 4'-CH2-C(=CH2)-2' 및 이의 유사체 (참고 예를 들면, Seth 등, U.S. 8,278,426), 4'-C(RaRb)-N(R)-O-2', 4'-C(RaRb)-O-N(R)-2', 4'-CH2-O-N(R)-2', 및 4'-CH2-N(R)-O-2', 상기 각 R, Ra, 및 Rb는, 독립적으로, H, 보호기, 또는 C1-C12 알킬임 (참고, 예를 들어 Imanishi 등, U.S. 7,427,672).
특정 구현예에서, 그와 같은 4' 내지 2' 브릿지는 독립적으로 하기로부터 독립적으로 선택된 1 내지 4개의 연결된 기를 포함한다: -[C(Ra)(Rb)]n-, -[C(Ra)(Rb)]n-O-, -C(Ra)=C(Rb)-, -C(Ra)=N-, -C(=NRa)-, -C(=O)-, -C(=S)-, -O-, -Si(Ra)2-, -S(=O)x-, 및 -N(Ra)-;
여기서:
x는 0, 1, 또는 2이고;
n은 1, 2, 3, 또는 4이고;
각 Ra 및 Rb는, 독립적으로, H, 보호기, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 복소환 라디칼, 치환된 복소환 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 지환족 라디칼, 치환된 C5-C7 지환족 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 설포닐 (S(=O)2-J1), 또는 설폭실 (S(=O)-J1)이고;
각 J1 및 J2는, 독립적으로, H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 아실, 복소환 라디칼, 치환된 복소환 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬, 또는 보호기임.
추가의 이환형 당 모이어티는 당해 기술에 공지되어 있다, 참고, 예를 들어: Freier 등, Nucleic Acids Research, 1997, 25(22), 4429-4443, Albaek 등, J. Org. Chem., 2006, 71, 7731-7740, Singh 등, Chem. Commun., 1998, 4, 455-456; Koshkin 등, Tetrahedron, 1998, 54, 3607-3630; Kumar 등, Bioorg. Med. Chem. Lett., 1998, 8, 2219-2222; Singh 등, J. Org. Chem., 1998, 63, 10035-10039; Srivastava 등, J. Am. Chem. Soc., 20017, 129, 8362-8379; Wengel et a., U.S. 7,053,207; Imanishi 등, U.S. 6,268,490; Imanishi 등. U.S. 6,770,748; Imanishi 등, U.S.RE44,779; Wengel 등, U.S. 6,794,499; Wengel 등, U.S. 6,670,461; Wengel 등, U.S. 7,034,133; Wengel 등, U.S. 8,080,644; Wengel 등, U.S. 8,034,909; Wengel 등, U.S. 8,153,365; Wengel 등, U.S. 7,572,582; 및 Ramasamy 등, U.S. 6,525,191;; Torsten 등, WO 2004/106356; Wengel 등, WO 1999/014226; Seth 등, WO 2007/134181; Seth 등, U.S. 7,547,684; Seth 등, U.S. 7,666,854; Seth 등, U.S. 8,088,746; Seth 등, U.S. 7,750,131; Seth 등, U.S. 8,030,467; Seth 등, U.S. 8,268,980; Seth 등, U.S. 8,546,556; Seth 등, U.S. 8,530,640; Migawa 등, U.S. 9,012,421; Seth 등, U.S. 8,501,805; 및 미국 특허 공보 번호 Allerson 등, US2008/0039618 및 Migawa 등, US2015/0191727.
특정 구현예에서, 이환형 당 모이어티 그리고 그와 같은 이환형 당 모이어티를 편입시키는 뉴클레오사이드는 추가로 이성질체 배치형태에 의해 정의된다. 예를 들어, (본 명세서에 기재된) LNA 뉴클레오사이드는 α-L 배치형태 또는 β-D 배치형태일 수 있다.
LNA (β-D-배치형태)
α-L-LNA (α-L-배치형태)
브릿지 = 4'-CH2-O-2'
브릿지 = 4'-CH2-O-2'
α-L-메틸렌옥시 (4'-CH2-O-2') 또는 α-L-LNA 이환형 뉴클레오사이드는 안티센스 활성을 보여주었던 올리고뉴클레오타이드에 편입되어 왔다 (Frieden 등, Nucleic Acids Research, 2003, 21, 6365-6372). 본 명세서에서, 이환형 뉴클레오사이드의 일반적인 설명은 두 이성질체 배치형태를 포함한다. 특이적 이환형 뉴클레오사이드 (예를 들면, LNA 또는 cEt)의 위치가 본 명세서에 예시된 구현예에서 확인되는 경우, 이들은, 달리 명시되지 않는 한, β-D 배치형태이다.
특정 구현예에서, 변형된 당 모이어티는 하나 이상의 비-브릿징 당 치환체 및 하나 이상의 브릿징 당 치환체 (예를 들면, 5'-치환된 및 4'-2' 브릿징된 당)을 포함한다.
특정 구현예에서, 변형된 당 모이어티는 당 대리물이다. 특정 상기 구현예에서, 당 모이어티의 산소 원자는, 예를 들면, 황, 탄소 또는 질소 원자로 대체된다. 특정 상기 구현예에서, 그와 같은 변형된 당 모이어티는 또한 본 명세서에 기재된 바와 같은 브릿징 및/또는 비-브릿징 치환체를 포함한다. 예를 들어, 특정 당 대리물은 2'-위치 (참고, 예를 들면, Bhat 등, U.S. 7,875,733 및 Bhat 등, U.S. 7,939,677) 및/또는 5' 위치에서 치환 및 4'-황 원자를 포함한다.
특정 구현예에서, 당 대리물은 5개 원자 이외를 가지고 있는 고리를 포함한다. 예를 들어, 특정 구현예에서, 당 대리물은 6-원 테트라하이드로피란 ("THP")를 포함한다. 그와 같은 테트라하이드로피란은 추가로 변형 또는 치환될 수 있다. 그와 같은 변형된 테트라하이드로피란을 포함하는 뉴클레오사이드는 비제한적으로 하기를 포함한다: 헥시톨 핵산 ("HNA"), 아니톨 핵산 ("ANA"), 만니톨 핵산 ("MNA") (참고, 예를 들면, Leumann, CJ.Bioorg.& Med. Chem.2002, 10, 841-854), 플루오로 HNA:
F-HNA
("F-HNA", 참고 예를 들어 Swayze 등, U.S. 8,088,904; Swayze 등, U.S. 8,440,803; Swayze 등, U.S. 8,796,437; 및 Swayze 등, U.S. 9,005,906; F-HNA는 또한 F-THP 또는 3'-플루오로 테트라하이드로피란으로서 지칭될 수 있다), 및 하기 식을 가지고 있는 추가의 변형된 THP 화합물을 포함하는 뉴클레오사이드:
여기서, 독립적으로, 상기 변형된 THP 뉴클레오사이드의 각각에 대하여:
Bx는 핵염기 모이어티이고;
T3 및 T4 각각은, 독립적으로, 올리고뉴클레오타이드의 나머지에 변형된 THP 뉴클레오사이드를 결합시키는 인터뉴클레오사이드 결합기이거나 T3 및 T4 중 하나는 올리고뉴클레오타이드의 나머지에 변형된 THP 뉴클레오사이드를 결합시키는 인터뉴클레오사이드 결합기이고 T3 및 T4 중 다른 하나는 H, 하이드록실 보호기, 연결된 컨쥬게이트 그룹, 또는 5' 또는 3'-말단기이고;
q1, q2, q3, q4, q5, q6 및 q7 각각은, 독립적으로, H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐, 또는 치환된 C2-C6 알키닐이고;
각각의 R1 및 R2는 하기중으로부터 독립적으로 선택된다: 수소, 할로겐, 치환된 또는 미치환된 알콕시, NJ1J2, SJ1, N3, OC(=X)J1, OC(=X)NJ1J2, NJ3C(=X)NJ1J2, 및 CN, 여기서 X는 O, S 또는 NJ1이고, 각 J1, J2, 및 J3은, 독립적으로, H 또는 C1-C6 알킬임.
특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 각각이 H인 변형된 THP 뉴클레오사이드는 제공된다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 H 이외이다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 메틸이다. 특정 구현예에서, R1 및 R2 중 하나가 F인 변형된 THP 뉴클레오사이드는 제공된다. 특정 구현예에서, R1은 F이고 R2는 H이고, 특정 구현예에서, R1은 메톡시이고 R2는 H이고, 특정 구현예에서, R1은 메톡시에톡시이고 R2는 H이다.
특정 구현예에서, 당 대리물은 5개 초과 원자 및 1개 초과 헤테로원자를 가지고 있는 고리를 포함한다. 예를 들어, 올리고뉴클레오타이드에서 모폴리노 당 모이어티를 포함하는 뉴클레오사이드 및 이의 용도는 보고되어 왔다 (참고, 예를 들면, Braasch 등, Biochemistry, 2002, 41, 4503-4510 및 Summerton 등, U.S. 5,698,685; Summerton 등, U.S. 5,166,315; Summerton 등, U.S. 5,185,444; 및 Summerton 등, U.S. 5,034,506). 여기에서 사용된 바와 같이, 용어 "모폴리노"는 하기 구조를 가지고 있는 당 대리물을 의미한다:
특정 구현예에서, 모폴리노는, 예를 들어 상기 모폴리노 구조로부터 다양한 치환기 첨가 또는 변경에 의해 변형될 수 있다. 그와 같은 당 대리물은 본 명세서에서 "변형된 모폴리노"로서 지칭된다.
특정 구현예에서, 당 대리물은 비환형 모이에이티를 포함한다. 그와 같은 비환형 당 대리물을 포함하는 뉴클레오사이드 및 올리고뉴클레오타이드의 예는 하기를 비제한적으로 포함한다: 펩타이드 핵산 ("PNA"), 비환형 부틸 핵산 (참고, 예를 들면, Kumar 등, Org. Biomol. Chem., 2013, 11, 5853-5865), 및 Manoharan 등, WO2011/133876에서 기재된 뉴클레오사이드 및 올리고뉴클레오타이드.
많은 다른 이환형 및 삼환형 당 및 당 대리물 고리계는 변형된 뉴클레오사이드에서 사용될 수 있는 당해 기술에 공지되어 있다).
2.
특정 변형된 핵염기
특정 구현예에서, 변형된 올리고뉴클레오타이드는 미변형된 핵염기를 포함하는 하나 이상의 뉴클레오사이드를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 하나 이상의 뉴클레오사이드를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는, 무염기성 뉴클레오사이드로서 지칭된, 핵염기를 포함하지 않는 하나 이상의 뉴클레오사이드를 포함한다.
특정 구현예에서, 변형된 핵염기는 하기로부터 선택된다: 5-치환된 피리미딘, 6-아자피리미딘, 알킬 또는 알키닐 치환된 피리미딘, 알킬 치환된 퓨린, 및 N-2, N-6 및 O-6 치환된 퓨린. 특정 구현예에서, 변형된 핵염기는 하기로부터 선택된다: 2-아미노프로필아데닌, 5-하이드록시메틸 시토신, 잔틴, 하이포잔틴, 2-아미노아데닌, 6-N-메틸구아닌, 6-N-메틸아데닌, 2-프로필아데닌 , 2-티오우라실, 2-티오티민 및 2-티오시토신, 5-프로피닐 (-C≡C-CH3) 우라실, 5-프로피닐시토신, 6-아조우라실, 6-아조시토신, 6-아조티민, 5-리보실우라실 (슈도우라실), 4-티오우라실, 8-할로, 8-아미노, 8-티올, 8-티오알킬, 8-하이드록실, 8-아자 및 다른 8-치환된 퓨린, 5-할로, 특히 5-브로모, 5-트리플루오로메틸, 5-할로우라실, 및 5-할로시토신, 7-메틸구아닌, 7-메틸아데닌, 2-F-아데닌, 2-아미노아데닌, 7-데아자구아닌, 7-데아자아데닌, 3-데아자구아닌, 3-데아자아데닌, 6-N-벤조일아데닌, 2-N-이소부티릴구아닌, 4-N-벤조일시토신, 4-N-벤조일우라실, 5-메틸 4-N-벤조일시토신, 5-메틸 4-N-벤조일우라실, 보편적인 염기, 소수성 염기, 부정확한 염기, 크기-팽창된 염기, 및 플루오르화된 염기. 추가 변형된 핵염기는 삼환형 피리미딘, 예컨대 1,3-디아자펜옥사진-2-온, 1,3-디아자페노티아진-2-온 및 9-(2-아미노에톡시)-1,3-디아자펜옥사진-2-온 (G-클램프)를 포함한다. 변형된 핵염기는 또한 퓨린 또는 피리미딘이 다른 헤테로사이클, 예를 들어 7-데아자-아데닌, 7-데아자구아노신, 2-아미노피리딘 및 2-피리돈으로 대체되는 것들을 포함할 수 있다. 추가 핵염기는 Merigan 등, U.S. 3,687,808에서 개시된 것, The Concise Encyclopedia Of Polymer Science And Engineering, Kroschwitz, J.I., Ed., John Wiley & Sons, 1990, 858-859; Englisch 등, Angewandte Chemie, International Edition, 1991, 30, 613; Sanghvi, Y.S., Chapter 15, Antisense Research and Applications, Crooke, S.T. and Lebleu, B., Eds., CRC Press, 1993, 273-288에서 개시된 것; 및 Chapters 6 and 15, Antisense Drug Technology, Crooke S.T., Ed., CRC Press, 2008, 163-166 및 442-443에서 개시된 것을 포함한다.
특정 상기 언급된 변형된 핵염기 뿐만 아니라 다른 변형된 핵염기의 제조를 교시하는 공보는 제한 없이, 하기를 포함한다: Manohara 등, US2003/0158403; Manoharan 등, US2003/0175906; Dinh 등, U.S. 4,845,205; Spielvogel 등, U.S. 5,130,302; Rogers 등, U.S. 5,134,066; Bischofberger 등, U.S. 5,175,273; Urdea 등, U.S. 5,367,066; Benner 등, U.S. 5,432,272; Matteucci 등, U.S. 5,434,257; Gmeiner 등, U.S. 5,457,187; Cook 등, U.S. 5,459,255; Froehler 등, U.S. 5,484,908; Matteucci 등, U.S. 5,502,177; Hawkins 등, U.S. 5,525,711; Haralambidis 등, U.S. 5,552,540; Cook 등, U.S. 5,587,469; Froehler 등, U.S. 5,594,121; Switzer 등, U.S. 5,596,091; Cook 등, U.S. 5,614,617; Froehler 등, U.S. 5,645,985; Cook 등, U.S. 5,681,941; Cook 등, U.S. 5,811,534; Cook 등, U.S. 5,750,692; Cook 등, U.S. 5,948,903; Cook 등, U.S. 5,587,470; Cook 등, U.S. 5,457,191; Matteucci 등, U.S. 5,763,588; Froehler 등, U.S. 5,830,653; Cook 등, U.S. 5,808,027; Cook 등, 6,166,199; 및 Matteucci 등, U.S. 6,005,096.
3.
특정 변형된 인터뉴클레오사이드 연결기
특정 구현예에서, 변형된 올리고뉴클레오타이드의 뉴클레오사이드는 임의의 인터뉴클레오사이드 연결기를 사용하여 함께 연결될 수 있다. 인터뉴클레오사이드 결합기의 2개의 주요 부류는 인 원자의 존재 또는 부재에 의해 정의된다. 대표적인 인-함유 인터뉴클레오사이드 연결기는 비제한적으로 포스페이트를 포함하고, 이는 포스포디에스테르 결합 ("P=O") (미변형된 또는 자연 발생 연결기로도 칭함), 포스포트리에스테르, 메틸포스포네이트, 포스포르아미데이트, 및 포스포로티오에이트 ("P=S"), 및 포스포로디티오에이트 ("HS-P=S")를 함유한다. 대표적인 비-인 함유 인터뉴클레오사이드 결합기는 비제한적으로 메틸렌메틸이미노 (-CH2-N(CH3)-O-CH2-), 티오디에스테르, 티오노카바메이트 (-O-C(=O)(NH)-S-); 실록산 (-O-SiH2-O-); 및 N,N'-디메틸하이드라진 (-CH2-N(CH3)-N(CH3)-)을 포함한다. 자연 발생 포스페이트 연결기에 비교된, 변형된 인터뉴클레오사이드 연결기는 올리고뉴클레오타이드의 뉴클레아제 내성을 변경, 전형적으로 증가시키는데 사용될 수 있다. 특정 구현예에서, 키랄 원자를 가지고 있는 인터뉴클레오사이드 연결기는 라세미 혼합물로서, 또는 별도의 거울상이성질체로서 제조될 수 있다. 인함유 및 비-인함유 인터뉴클레오사이드 연결기의 제조 방법은 당해 분야의 숙련가에게 잘 알려진다.
키랄 중심을 가지고 있는 대표적인 인터뉴클레오사이드 연결기는 비제한적으로 알킬포스포네이트 및 포스포로티오에이트를 포함한다. 키랄 중심을 가지고 있는 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드는 스테레오랜덤 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드의 집단으로서, 또는 특정 입체화학적 배치형태로 포스포로티오에이트 연결기를 포함하는 변형된 올리고뉴클레오타이드의 집단으로서 제조될 수 있다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 집단은 모든 포스포로티오에이트 인터뉴클레오사이드 연결기가 스테레오랜덤인 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함한다. 그와 같은 변형된 올리고뉴클레오타이드는 각 포스포로티오에이트 연결기의 입체화학적 배치형태의 랜덤 선택을 초래하는 합성 방법을 사용하여 생성될 수 있다. 그럼에도 불구하고, 당해 분야의 숙련가에 의해 잘 이해되는 바와 같이, 각 개별 올리고뉴클레오타이드 분자의 각 개별 포스포로티오에이트는 정의된 배치형태를 갖는다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 집단은 특정, 독립적으로 선택된 입체화학적 배치형태에서 하나 이상의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 구현예에서, 특정 포스포로티오에이트 연결기의 특정 배치형태는 집단에서 분자의 적어도 65%에서 존재한다. 특정 구현예에서, 특정 포스포로티오에이트 연결기의 특정 배치형태는 집단에서 분자의 적어도 70%에서 존재한다. 특정 구현예에서, 특정 포스포로티오에이트 연결기의 특정 배치형태는 집단에서 분자의 적어도 80%에서 존재한다. 특정 구현예에서, 특정 포스포로티오에이트 연결기의 특정 배치형태는 집단에서 분자의 적어도 90%에서 존재한다. 특정 구현예에서, 특정 포스포로티오에이트 연결기의 특정 배치형태는 집단에서 분자의 적어도 99%에서 존재한다. 변형된 올리고뉴클레오타이드의 그와 같은 키랄 풍부 집단은 당업계에서 알려진 합성 방법, 예를 들면, Oka 등, JACS 125, 8307 (2003), Wan 등. Nuc. Acid. Res. 42, 13456 (2014), 및 WO 2017/015555에서 기재된 방법을 사용하여 생성될 수 있다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 집단은 (Sp) 배치형태에서 적어도 하나의 지시된 포스포로티오에이트를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 집단은 (Rp) 배치형태에서 적어도 하나의 포스포로티오에이트를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부하다. 특정 구현예에서, (Rp) 및/또는 (Sp) 포스포로티오에이트를 포함하는 변형된 올리고뉴클레오타이드는, "B"가 핵염기를 나타내는, 하나 이상의 하기 식, 각각을 포함한다:
달리 나타내지 않는 한, 본 명세서에 기재된 변형된 올리고뉴클레오타이드의 키랄 인터뉴클레오사이드 연결기는 스테레오랜덤일 수 있거나 특정 입체화학적 배치형태일 수 있다.
중성 인터뉴클레오사이드 연결기는, 제한 없이, 포스포트리에스테르, 메틸포스포네이트, MMI (3'-CH2-N(CH3)-O-5'), 아미드-3 (3'-CH2-C(=O)-N(H)-5'), 아미드-4 (3'-CH2-N(H)-C(=O)-5'), 포름아세탈 (3'-O-CH2-O-5'), 메톡시프로필, 및 티오포름아세탈 (3'-S-CH2-O-5')를 포함한다. 추가 중성 인터뉴클레오사이드 연결기는 실록산 (디알킬실록산), 카복실레이트 에스테르, 카복사미드, 설파이드, 설포네이트 에스테르 및 아미드를 포함하는 비이온성 연결기를 포함한다 (참고 예를 들어: Carbohydrate Modifications in Antisense Research; Y. S. Sanghvi and P. D. Cook, Eds., ACS Symposium Series 580; Chapters 3 and 4, 40-65). 추가 중성 인터뉴클레오사이드 연결기는 혼합된 N, O, S 및 CH2 성분 부분을 포함하는 비이온성 연결기를 포함한다.
B.
특정 모티프
특정 구현예에서, 변형된 올리고뉴클레오타이드는 변형된 당 모이어티를 포함하는 하나 이상의 변형된 뉴클레오사이드를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 하나 이상의 변형된 뉴클레오사이드를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 하나 이상의 변형된 인터뉴클레오사이드 연결기를 포함한다. 상기 구현예에서, 변형된 올리고뉴클레오타이드의 변형된, 미변형된, 및 상이하게 변형된 당 모이어티, 핵염기, 및/또는 인터뉴클레오사이드 연결기는 패턴 또는 모티프를 정의한다. 특정 구현예에서, 당 모이어티, 핵염기, 및 인터뉴클레오사이드 연결기의 패턴 각각은 서로 독립적이다. 따라서, 변형된 올리고뉴클레오타이드는 그것의 당 모티프, 핵염기 모티프 및/또는 인터뉴클레오사이드 연결기 모티프에 의해 기재될 수 있다 (본 명세서에 사용된 바와 같이, 핵염기 모티프는 핵염기의 서열에 독립적인 핵염기에 대한 변형을 기재한다).
1.
특정 당 모티프
특정 구현예에서, 올리고뉴클레오타이드는 정의된 패턴 또는 당 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 당 및/또는 미변형된 당 모이어티의 하나 이상의 유형을 포함한다. 특정 사례에서, 그와 같은 당 모티프는 비제한적으로 본 명세서에 논의된 임의의 당 변형을 포함한다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는, 2개의 외부 영역 즉 "윙" 그리고 중심 또는 내부 영역 즉 "갭"에 의해 정의되는, 갭머 모티프를 가지고 있는 영역을 포함하거나 상기로 이루어진다. 갭머 모티프의 3개의 영역 (5'-윙, 갭, 및 3'-윙)은 윙의 각각의 뉴클레오사이드의 당 모이어티의 적어도 일부가 갭의 뉴클레오사이드의 당 모이어티의 적어도 일부와 상이한 뉴클레오사이드의 연속적 서열을 형성한다. 구체적으로, 갭에 가장 가까운 각 윙의 뉴클레오사이드 (5'-윙의 3'-최말단 뉴클레오사이드 및 3'-윙의 5'-최말단 뉴클레오사이드)의 적어도 당 모이어티는 이웃한 갭 뉴클레오사이드의 당 모이어티와 상이하고, 따라서 윙들과 갭 사이 경계 (즉, 윙/갭 접합)을 정의한다. 특정 구현예에서, 갭 내에서 당 모이어티는 서로 동일하다. 특정 구현예에서, 갭은 갭의 하나 이상의 다른 뉴클레오사이드의 당 모이어티와 상이한 당 모이어티를 가지고 있는 하나 이상의 뉴클레오사이드를 포함한다. 특정 구현예에서, 2개 윙의 당 모티프는 서로 (대칭 갭머) 동일하다. 특정 구현예에서, 5'-윙의 당 모티프는 3'-윙 (비대칭 갭머)의 당 모티프와 상이하다.
특정 구현예에서, 갭머의 윙은 1-5개의 뉴클레오사이드를 포함한다. 특정 구현예에서, 갭머의 각 윙의 각 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서, 갭머의 각 윙의 적어도 1개의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서, 갭머의 각 윙의 적어도 2개의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서, 갭머의 각 윙의 적어도 3개의 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서, 갭머의 각 윙의 적어도 4개의 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 구현예에서, 갭머의 갭은 7-12개의 뉴클레오사이드를 포함한다. 특정 구현예에서, 갭머의 갭의 각 뉴클레오사이드는 미변형된 2'-데옥시 뉴클레오사이드이다. 특정 구현예에서, 갭머의 갭의 적어도 1개의 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 구현예에서, 갭머는 데옥시 갭머이다. 특정 구현예에서, 각 윙/갭 접합의 갭 측에서 뉴클레오사이드는 미변형된 2'-데옥시 뉴클레오사이드이고 각 윙/갭 접합의 윙 측에서 뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서, 갭의 각 뉴클레오사이드는 미변형된 2'-데옥시 뉴클레오사이드이다. 특정 구현예에서, 갭머의 각 윙의 각 뉴클레오사이드는 변형된 뉴클레오사이드이다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 완전하게 변형된 당 모티프를 가지고 있는 영역을 포함하거나 상기로 이루어진다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 완전하게 변형된 영역의 각 뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 구현예에서, 전체 변형된 올리고뉴클레오타이드의 각 뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 완전하게 변형된 당 모티프를 가지고 있는 영역을 포함하거나 상기로 이루어지고, 여기서 완전하게 변형된 영역 내에서 각 뉴클레오사이드는, 본 명세서에서 균일하게 변형된 당 모티프로서 지칭된, 동일한 변형된 당 모이어티를 포함한다. 특정 구현예에서, 완전하게 변형된 올리고뉴클레오타이드는 균일하게 변형된 올리고뉴클레오타이드이다. 특정 구현예에서, 균일하게 변형된의 각 뉴클레오사이드는 동일한 2'-변형을 포함한다.
본 명세서에, 갭머의 3개의 영역의 길이 (뉴클레오사이드의 수)는 표기법 [5'-윙에서 뉴클레오사이드의 #] - [갭에서 뉴클레오사이드의 #] - [3'-윙에서 뉴클레오사이드의 #]를 사용하여 제공될 수 있다. 따라서, 5-10-5 갭머는 각 윙에서 5개의 연결된 뉴클레오사이드 및 갭에서 10개의 연결된 뉴클레오사이드로 이루어진다. 그와 같은 명명법이 특정 변형에 뒤따르는 경우, 그 변형은 각 윙의 각 당 모이어티에서 변형이고 갭 뉴클레오사이드는 미변형된 데옥시뉴클레오사이드 당을 포함한다. 따라서, 5-10-5 MOE 갭머는 5'-윙에서 5개의 연결된 MOE 변형된 뉴클레오사이드, 갭에서 10개의 연결된 데옥시뉴클레오사이드, 그리고 3'-윙에서 5개의 연결된 MOE 뉴클레오사이드로 이루어진다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 3-10-3 BNA 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 3-10-3 cEt 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 3-10-3 LNA 갭머이다.
2.
특정 핵염기 모티프
특정 구현예에서, 올리고뉴클레오타이드는 정의된 패턴 또는 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 및/또는 미변형된 핵염기를 포함한다. 특정 구현예에서, 각 핵염기는 변형된다. 특정 구현예에서, 핵염기의 어느 것도 변형되지 않는다. 특정 구현예에서, 각 퓨린 또는 각 피리미딘은 변형된다. 특정 구현예에서, 각 아데닌은 변형된다. 특정 구현예에서, 각 구아닌은 변형된다. 특정 구현예에서, 각 티민은 변형된다. 특정 구현예에서, 각 우라실은 변형된다. 특정 구현예에서, 각 시토신은 변형된다. 특정 구현예에서, 변형된 올리고뉴클레오타이드에서 일부 또는 모든 시토신 핵염기는 5-메틸 시토신이다. 특정 구현예에서, 시토신 핵염기의 모두는 5-메틸 시토신이고 변형된 올리고뉴클레오타이드의 다른 핵염기의 모두는 미변형된 핵염기이다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 변형된 핵염기의 블록을 포함한다. 특정 상기 구현예에서, 블록은 올리고뉴클레오타이드의 3'-말단에 있다. 특정 구현예에서 블록은 올리고뉴클레오타이드의 3'-말단의 3개 뉴클레오사이드 내에 있다. 특정 구현예에서, 블록은 올리고뉴클레오타이드의 5'-말단에 있다. 특정 구현예에서 블록은 올리고뉴클레오타이드의 5'-말단의 3개 뉴클레오사이드 내에 있다.
특정 구현예에서, 갭머 모티프를 가지고 있는 올리고뉴클레오타이드는 변형된 핵염기를 포함하는 뉴클레오사이드를 포함한다. 특정 상기 구현예에서, 변형된 핵염기를 포함하는 1개의 뉴클레오사이드는 갭머 모티프를 가지고 있는 올리고뉴클레오타이드의 중심 갭에 있다. 특정 상기 구현예에서, 상기 뉴클레오사이드의 당 모이어티는 2'-데옥시리보실 모이어티이다. 특정 구현예에서, 변형된 핵염기는 하기로부터 선택된다: 2-티오피리미딘 및 5-프로핀피리미딘.
3.
특정 인터뉴클레오사이드 연결기 모티프
특정 구현예에서, 올리고뉴클레오타이드는 정의된 패턴 또는 모티프에서 올리고뉴클레오타이드 또는 이의 영역을 따라 배열된 변형된 및/또는 미변형된 인터뉴클레오사이드 연결기를 포함한다. 특정 구현예에서, 각 인터뉴클레오사이드 결합기는 포스포디에스테르 인터뉴클레오사이드 연결기 (P=O)이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 각 인터뉴클레오사이드 결합기는 포스포로티오에이트 인터뉴클레오사이드 연결기 (P=S)이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 각 인터뉴클레오사이드 연결기는 독립적으로 포스포로티오에이트 인터뉴클레오사이드 연결기 및 포스포디에스테르 인터뉴클레오사이드 연결기로부터 선택된다. 특정 구현예에서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기는 독립적으로 스테레오랜덤 포스포로티오에이트, (Sp) 포스포로티오에이트, 및 (Rp) 포스포로티오에이트로부터 선택된다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 당 모티프는 갭머이고 갭 내에서 인터뉴클레오사이드 연결기 모두는 변형된다. 특정 상기 구현예에서, 윙에서 일부 또는 모든 인터뉴클레오사이드 연결기는 미변형된 포스포디에스테르 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 말단 인터뉴클레오사이드 연결기는 변형된다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 당 모티프는 갭머이고, 인터뉴클레오사이드 연결기 모티프는 적어도 하나의 윙에서 적어도 하나의 포스포디에스테르 인터뉴클레오사이드 연결기를 포함하고, 여기서 상기 적어도 하나의 포스포디에스테르 연결기는 말단 인터뉴클레오사이드 연결기가 아니고, 나머지 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이다. 특정 상기 구현예에서, 모든 포스포로티오에이트 연결기는 스테레오랜덤이다. 특정 구현예에서, 윙에서 모든 포스포로티오에이트 연결기는 (Sp) 포스포로티오에이트이고, 갭은 적어도 하나의 Sp, Sp, Rp 모티프를 포함한다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 집단은 그와 같은 인터뉴클레오사이드 연결기 모티프를 포함하는 변형된 올리고뉴클레오타이드가 풍부하다.
C.
특정 길이
활성 제거 없이 올리고뉴클레오타이드의 길이를 증가 또는 감소하는 것은 가능하다. 예를 들어, Woolf 등 (Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992)에서, 13-25개의 핵염기 길이의 일련의 올리고뉴클레오타이드는 난모세포 주입 모델에서 표적 RNA의 절단을 유도하기 위한 그들의 능력에 대하여 시험되었다. 올리고뉴클레오타이드의 말단 근처에 8 또는 11개의 미스매치 염기가 있는 25개의 핵염기 길이의 올리고뉴클레오타이드는, 미스매치를 함유하지 않았던 올리고뉴클레오타이드보다 더 적은 정도에도 불구하고, 표적 RNA의 특이적 절단을 유도할 수 있었다. 유사하게, 표적 특이적 절단은, 1 또는 3개의 미스매치가 있는 것을 포함하여, 13개의 핵염기 올리고뉴클레오타이드를 사용하여 달성되었다.
특정 구현예에서, (변형된 올리고뉴클레오타이드를 포함하는) 올리고뉴클레오타이드는 임의의 다양한 범위의 길이를 가질 수 있다. 특정 구현예에서, 올리고뉴클레오타이드는 X 내지 Y개의 연결된 뉴클레오사이드로 이루어지고, 여기에서 X는 범위에서 뉴클레오사이드의 가장 적은 수를 나타내고 Y는 범위에서 최대 수 뉴클레오사이드를 나타낸다. 특정 상기 구현예에서, X 및 Y는 각각 독립적으로 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 및 50으로부터 선택된다; 단 X≤Y. 예를 들어, 특정 구현예에서, 올리고뉴클레오타이드는 12 내지 13, 12 내지 14, 12 내지 15, 12 내지 16, 12 내지 17, 12 내지 18, 12 내지 19, 12 내지 20, 12 내지 21, 12 내지 22, 12 내지 23, 12 내지 24, 12 내지 25, 12 내지 26, 12 내지 27, 12 내지 28, 12 내지 29, 12 내지 30, 13 내지 14, 13 내지 15, 13 내지 16, 13 내지 17, 13 내지 18, 13 내지 19, 13 내지 20, 13 내지 21, 13 내지 22, 13 내지 23, 13 내지 24, 13 내지 25, 13 내지 26, 13 내지 27, 13 내지 28, 13 내지 29, 13 내지 30, 14 내지 15, 14 내지 16, 14 내지 17, 14 내지 18, 14 내지 19, 14 내지 20, 14 내지 21, 14 내지 22, 14 내지 23, 14 내지 24, 14 내지 25, 14 내지 26, 14 내지 27, 14 내지 28, 14 내지 29, 14 내지 30, 15 내지 16, 15 내지 17, 15 내지 18, 15 내지 19, 15 내지 20, 15 내지 21, 15 내지 22, 15 내지 23, 15 내지 24, 15 내지 25, 15 내지 26, 15 내지 27, 15 내지 28, 15 내지 29, 15 내지 30, 16 내지 17, 16 내지 18, 16 내지 19, 16 내지 20, 16 내지 21, 16 내지 22, 16 내지 23, 16 내지 24, 16 내지 25, 16 내지 26, 16 내지 27, 16 내지 28, 16 내지 29, 16 내지 30, 17 내지 18, 17 내지 19, 17 내지 20, 17 내지 21, 17 내지 22, 17 내지 23, 17 내지 24, 17 내지 25, 17 내지 26, 17 내지 27, 17 내지 28, 17 내지 29, 17 내지 30, 18 내지 19, 18 내지 20, 18 내지 21, 18 내지 22, 18 내지 23, 18 내지 24, 18 내지 25, 18 내지 26, 18 내지 27, 18 내지 28, 18 내지 29, 18 내지 30, 19 내지 20, 19 내지 21, 19 내지 22, 19 내지 23, 19 내지 24, 19 내지 25, 19 내지 26, 19 내지 29, 19 내지 28, 19 내지 29, 19 내지 30, 20 내지 21, 20 내지 22, 20 내지 23, 20 내지 24, 20 내지 25, 20 내지 26, 20 내지 27, 20 내지 28, 20 내지 29, 20 내지 30, 21 내지 22, 21 내지 23, 21 내지 24, 21 내지 25, 21 내지 26, 21 내지 27, 21 내지 28, 21 내지 29, 21 내지 30, 22 내지 23, 22 내지 24, 22 내지 25, 22 내지 26, 22 내지 27, 22 내지 28, 22 내지 29, 22 내지 30, 23 내지 24, 23 내지 25, 23 내지 26, 23 내지 27, 23 내지 28, 23 내지 29, 23 내지 30, 24 내지 25, 24 내지 26, 24 내지 27, 24 내지 28, 24 내지 29, 24 내지 30, 25 내지 26, 25 내지 27, 25 내지 28, 25 내지 29, 25 내지 30, 26 내지 27, 26 내지 28, 26 내지 29, 26 내지 30, 27 내지 28, 27 내지 29, 27 내지 30, 28 내지 29, 28 내지 30, 또는 29 내지 30개의 연결된 뉴클레오사이드로 이루어진다.
D.
특정 변형된 올리고뉴클레오타이드
특정 구현예에서, 상기 변형 (당, 핵염기, 인터뉴클레오사이드 연결기)는 변형된 올리고뉴클레오타이드 속에 편입된다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 그들의 변형 모티프 및 전체적인 길이를 특징으로 한다. 특정 구현예에서, 그와 같은 파라미터 각각은 서로 독립적이다. 따라서, 달리 나타내지 않는 한, 갭머 당 모티프를 가지고 있는 올리고뉴클레오타이드의 각 인터뉴클레오사이드 연결기는 변형될 수 있거나 미변형될 수 있고 당 변형의 갭머 변형 패턴을 따를 수 있거나 따르지 않을 수 있다. 예를 들어, 당 갭머의 윙 영역 내에서 인터뉴클레오사이드 연결기는 서로 동일 또는 상이할 수 있고 당 모티프의 갭 영역의 인터뉴클레오사이드 연결기와 동일 또는 상이할 수 있다. 마찬가지로, 그와 같은 당 갭머 올리고뉴클레오타이드는 당 변형의 갭머 패턴과 독립적인 하나 이상의 변형된 핵염기를 포함할 수 있다. 달리 나타내지 않는 한, 모든 변형은 핵염기 서열과 독립적이다.
E.
변형된 올리고뉴클레오타이드의 특정 집단
집단의 모든 변형된 올리고뉴클레오타이드가 동일한 분자식을 갖는 변형된 올리고뉴클레오타이드의 집단은 스테레오랜덤 집단 또는 키랄 풍부 집단일 수 있다. 모든 변형된 올리고뉴클레오타이드의 모든 키랄 중심은 스테레오랜덤 집단에서 스테레오랜덤이다. 키랄 풍부 집단에서, 적어도 하나의 특정 키랄 중심은 집단의 변형된 올리고뉴클레오타이드에서 스테레오랜덤이 아니다. 특정 구현예에서, 키랄 풍부 집단의 변형된 올리고뉴클레오타이드는 β-D 리보실 당 모이어티가 풍부하고, 모든 포스포로티오에이트 인터뉴클레오사이드 연결기는 스테레오렌덤이다. 특정 구현예에서, 키랄 풍부 집단의 변형된 올리고뉴클레오타이드는 특정 입체화학적 배치형태에서 β-D 리보실 당 모이어티 및 적어도 하나의, 특정 포스포로티오에이트 인터뉴클레오사이드 연결기 둘 모두가 풍부하다.
F.
핵염기 서열
특정 구현예에서, 올리고뉴클레오타이드 (미변형된 또는 변형된 올리고뉴클레오타이드)는 그들의 핵염기 서열에 의해 추가로 기재된다. 특정 구현예에서 올리고뉴클레오타이드는 제2 올리고뉴클레오타이드 또는 확인된 참고 핵산, 예컨대 표적 핵산에 상보성인 핵염기 서열을 가지고 있다. 특정 상기 구현예에서, 올리고뉴클레오타이드의 영역은 제2 올리고뉴클레오타이드 또는 확인된 참고 핵산, 예컨대 표적 핵산에 상보성인 핵염기 서열을 갖는다. 특정 구현예에서, 올리고뉴클레오타이드의 영역 또는 전체 길이의 핵염기 서열은 제2 올리고뉴클레오타이드 또는 핵산, 예컨대 표적 핵산에 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성이다.
II.
특정 올리고머성 화합물
특정 구현예에서, (변형된 또는 미변형된) 올리고뉴클레오타이드 및 선택적으로 하나 이상의 컨쥬게이트 그룹 및/또는 말단기로 이루어지는, 올리고머성 화합물은 본 명세서에 제공된다. 컨쥬게이트 그룹은 컨쥬게이트 모이어티를 올리고뉴클레오타이드에 결합시키는 하나 이상의 컨쥬게이트 모이어티 및 컨쥬게이트 링커로 이루어진다. 컨쥬게이트 그룹은 올리고뉴클레오타이드의 어느 한쪽 또는 양쪽 말단에 및/또는 임의의 내부 위치에 부착될 수 있다. 특정 구현예에서, 컨쥬게이트 그룹은 변형된 올리고뉴클레오타이드의 뉴클레오사이드의 2'-위치에 부착된다. 특정 구현예에서, 올리고뉴클레오타이드의 어느 한쪽 또는 양쪽 말단에 부착되는 컨쥬게이트 그룹은 말단기이다. 특정 상기 구현예에서, 컨쥬게이트 그룹 또는 말단기는 올리고뉴클레오타이드의 3' 및/또는 5'-말단에 부착된다. 특정 상기 구현예에서, 컨쥬게이트 그룹 (또는 말단기)는 올리고뉴클레오타이드의 3'-말단에 부착된다. 특정 구현예에서, 컨쥬게이트 그룹은 올리고뉴클레오타이드의 3'-말단 근처에 부착된다. 특정 구현예에서, 컨쥬게이트 그룹 (또는 말단기)는 올리고뉴클레오타이드의 5'-말단에 부착된다. 특정 구현예에서, 컨쥬게이트 그룹은 올리고뉴클레오타이드의 5'-말단 근처에 부착된다.
말단기의 예는 비제한적으로 컨쥬게이트 그룹, 캡핑 그룹, 포스페이트 모이어티, 보호기, 변형된 또는 미변형된 뉴클레오사이드, 및 독립적으로 변형 또는 미변형되는 2개 이상의 뉴클레오사이드를 포함한다.
A.
특정 컨쥬게이트 그룹
특정 구현예에서, 올리고뉴클레오타이드는 하나 이상의 컨쥬게이트 그룹에 공유적으로 부착된다. 특정 구현예에서, 컨쥬게이트 그룹은, 비제한적으로 약력학, 약동학, 안정성, 결합, 흡수, 조직 분포, 세포 분포, 세포 흡수, 충전 및 청소능을 포함하는, 부착된 올리고뉴클레오타이드의 하나 이상의 특성을 변형시킨다. 특정 구현예에서, 컨쥬게이트 그룹은 올리고뉴클레오타이드의 검출을 가능하게 하는 부착된 올리고뉴클레오타이드, 예를 들면, 형광단 또는 리포터 그룹에 신규한 특성을 부여한다. 특정 컨쥬게이트 그룹 및 컨쥬게이트 모이어티, 예를 들어 하기는 이전에 기재되어 왔다: 콜레스테롤 모이어티 (Letsinger 등, Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556), 콜산 (Manoharan 등, Bioorg. Med. Chem.Lett., 1994, 4, 1053-1060), 티오에테르, 예를 들면, 헥실-S-트리틸티올 (Manoharan 등, Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan 등, Bioorg. Med. Chem.Lett., 1993, 3, 2765-2770), 티오콜레스테롤 (Oberhauser 등, Nucl. Acids Res., 1992, 20, 533-538), 지방족 사슬, 예를 들면, 도데칸디올 또는 운데실 잔기 (Saison-Behmoaras 등, EMBO J., 1991, 10, 1111-1118; Kabanov 등, FEBS Lett., 1990, 259, 327-330; Svinarchuk 등, Biochimie, 1993, 75, 49-54), 인지질, 예를 들면, 디-헥사데실-rac-글리세롤 또는 트리에틸암모늄 1,2-디-O-헥사데실-rac-글리세로-3-H-포스포네이트 (Manoharan 등, Tetrahedron Lett., 1995, 36, 3651-3654; Shea 등, Nucl. Acids Res., 1990, 18, 3777-3783), 폴리아민 또는 폴리에틸렌 글리콜 사슬 (Manoharan 등, Nucleosides & Nucleotides, 1995, 14, 969-973), 또는 아다만탄 아세트산, 팔미틸 모이어티 (Mishra 등, Biochim. Biophys. Acta, 1995, 1264, 229-237), 옥타데실아민 또는 헥실아미노-카보닐-옥시콜레스테롤 모이어티 (Crooke 등, J. Pharmacol.Exp. Ther., 1996, i, 923-937), 토코페롤 그룹 (Nishina 등, Molecular Therapy Nucleic Acids, 2015, 4, e220; 및 Nishina 등, Molecular Therapy, 2008, 16, 734-740), 또는 GalNAc 클러스터 (예를 들면, WO2014/179620).
1.
컨쥬게이트 모이어티
컨쥬게이트 모이어티는, 제한 없이, 삽입제, 리포터 분자, 폴리아민, 폴리아미드, 펩타이드, 탄수화물, 비타민 모이어티, 폴리에틸렌 글리콜, 티오에테르, 폴리에테르, 콜레스테롤, 티오콜레스테롤, 콜산 모이어티, 폴레이트, 지질, 인지질, 바이오틴, 펜아진, 펜안트리딘, 안트라퀴논, 아다만탄, 아크리딘, 플루오레세인, 로다민, 쿠마린, 형광단, 및 염료를 포함한다.
특정 구현예에서, 컨쥬게이트 모이어티는 활성 약물 서브스턴스, 예를 들어, 아스피린, 와파린, 페닐부타존, 이부프로펜, 수프로펜, 펜-부펜, 케토프로펜, (S)-(+)-프라노프로펜, 카프로펜, 단실사르코신, 2,3,5-트리아이오도벤조산, 핑골리모드, 플루페남산, 폴린산, 벤조티아디아자이드, 클로로티아자이드, 디아제핀, 인도-메티신, 바르비투레이트, 세팔로스포린, 설파 약물, 항당뇨병제, 항균제 또는 항생제를 포함한다.
2.
컨쥬게이트 링커
컨쥬게이트 모이어티는 컨쥬게이트 링커를 통해 올리고뉴클레오타이드에 부착된다. 특정 올리고머성 화합물에서, 컨쥬게이트 링커는 단일 화학적 결합이다 (즉 컨쥬게이트 모이어티는 단일 결합을 거쳐 올리고뉴클레오타이드에 직접적으로 부착된다). 특정 구현예에서, 컨쥬게이트 링커는 사슬 구조, 예컨대 하이드로카르빌 사슬, 또는 반복 유닛 예컨대 에틸렌 글리콜, 뉴클레오사이드, 또는 아미노산 유닛의 올리고머를 포함한다.
특정 구현예에서, 컨쥬게이트 링커는 알킬, 아미노, 옥소, 아미드, 디설파이드, 폴리에틸렌 글리콜, 에테르, 티오에테르, 및 하이드록실아미노로부터 선택된 하나 이상의 기를 포함한다. 특정 상기 구현예에서, 컨쥬게이트 링커는 알킬, 아미노, 옥소, 아미드 및 에테르 기로부터 선택된 기를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 알킬 및 아미드 기로부터 선택된 기를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 알킬 및 에테르 기로부터 선택된 기를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 적어도 하나의 인 모이어티를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 적어도 하나의 포스페이트 기를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 적어도 하나의 중성 결합기를 포함한다.
특정 구현예에서, 상기 기재된 컨쥬게이트 링커를 포함하는, 컨쥬게이트 링커는 모 화합물, 예컨대 본 명세서에 제공된 올리고뉴클레오타이드에 컨쥬게이트 그룹 부착에 유용해지기 위해 2관능성 결합 모이어티, 예를 들면, 당해 분야에서 알려진 것들이다. 일반적으로, 2관능성 결합 모이어티는 적어도 2개의 관능성 그룹을 포함한다. 관능성 그룹 중 하나는 모 화합물 상의 특정 부위에 결합하기 위해 선택되고 다른 것은 컨쥬게이트 그룹에 결합하기 위해 선택된다. 2관능성 결합 모이어티에서 사용된 관능성 그룹의 예는 비제한적으로 친핵성 기와 반응하기 위한 친전자체 그리고 친전자성 기와 반응하기 위한 친핵체를 포함한다. 특정 구현예에서, 2관능성 결합 모이어티는 아미노, 하이드록실, 카복실산, 티올, 알킬, 알케닐, 및 알키닐로부터 선택된 하나 이상의 기를 포함한다.
컨쥬게이트 링커의 예는 비제한적으로 피롤리딘, 8-아미노-3,6-디옥사옥탄산 (ADO), 석신이미딜 4-(N-말레이미도메틸) 사이클로헥산-1-카복실레이트 (SMCC) 및 6-아미노헥산산 (AHEX 또는 AHA)를 포함한다. 다른 컨쥬게이트 링커는 비제한적으로 치환된 또는 미치환된 C1-C10 알킬, 치환된 또는 미치환된 C2-C10 알케닐 또는 치환된 또는 미치환된 C2-C10 알키닐을 포함하고, 여기서 바람직한 치환기의 비제한 목록은 하이드록실, 아미노, 알콕시, 카복시, 벤질, 페닐, 니트로, 티올, 티오알콕시, 할로겐, 알킬, 아릴, 알케닐 및 알키닐을 포함한다.
특정 구현예에서, 컨쥬게이트 링커는 1-10개의 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 2-5개의 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 정확히 3개의 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 TCA 모티프를 포함한다. 특정 구현예에서, 그와 같은 링커-뉴클레오사이드는 변형된 뉴클레오사이드이다. 특정 구현예에서 그와 같은 링커-뉴클레오사이드는 변형된 당 모이어티를 포함한다. 특정 구현예에서, 링커-뉴클레오사이드는 미변형된다. 특정 구현예에서, 링커-뉴클레오사이드는 퓨린, 치환된 퓨린, 피리미딘 또는 치환된 피리미딘으로부터 선택된 선택적으로 보호된 복소환형 염기를 포함한다. 특정 구현예에서, 절단가능한 모이어티는 우라실, 티민, 시토신, 4-N-벤조일시토신, 5-메틸 시토신, 4-N-벤조일-5-메틸 시토신, 아데닌, 6-N-벤조일아데닌, 구아닌 및 2-N-이소부티릴구아닌으로부터 선택된 뉴클레오사이드이다. 링커-뉴클레오사이드가 표적 조직에 도달한 후 올리고머성 화합물로부터 절단되는 것이 전형적으로 바람직하다. 따라서, 링커-뉴클레오사이드는 절단가능한 결합을 통해 올리고머성 화합물의 서로에 그리고 나머지에 전형적으로 연결된다. 특정 구현예에서, 그와 같은 절단가능한 결합은 포스포디에스테르 결합이다.
본 명세서에서, 링커-뉴클레오사이드는 올리고뉴클레오타이드의 일부인 것으로 간주되지 않는다. 따라서, 올리고머성 화합물이 참고 핵산에 명시된 퍼센트 상보성 및/또는 연결된 뉴클레오사이드의 명시된 수 또는 범위로 이루어지는 올리고뉴클레오타이드를 포함하고 올리고머성 화합물이 또한 링커-뉴클레오사이드를 포함하는 컨쥬게이트 링커를 포함하는 컨쥬게이트 그룹을 포함하는 구현예에서, 그들 링커-뉴클레오사이드는 올리고뉴클레오타이드의 길이를 대해 계수되지 않고 참고 핵산에 대하여 올리고뉴클레오타이드의 퍼센트 상보성 결정에 사용되지 않는다. 예를 들어, 올리고머성 화합물은 (1) 8-30개의 뉴클레오사이드로 이루어지는 변형된 올리고뉴클레오타이드 및 (2) 변형된 올리고뉴클레오타이드의 뉴클레오사이드로 연속인 1-10개의 링커-뉴클레오사이드를 포함하는 컨쥬게이트 그룹을 포함할 수 있다. 그와 같은 올리고머성 화합물에서 연속적 연결된 뉴클레오사이드의 총 수는 30개 초과이다. 대안적으로, 올리고머성 화합물은 8-30개의 뉴클레오사이드로 이루어지고 컨쥬게이트 그룹이 없는 변형된 올리고뉴클레오타이드를 포함할 수 있다. 그와 같은 올리고머성 화합물에서 연속적 연결된 뉴클레오사이드의 총 수는 30개 이하이다. 달리 나타내지 않는 한 컨쥬게이트 링커는 10개 이하 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 5개 이하 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 3개 이하 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 2개 이하 링커-뉴클레오사이드를 포함한다. 특정 구현예에서, 컨쥬게이트 링커는 1개 이하 링커-뉴클레오사이드를 포함한다.
특정 구현예에서, 컨쥬게이트 그룹이 올리고뉴클레오타이드로부터 절단되는 것이 바람직하다. 예를 들어, 특정 상황에서 특정 컨쥬게이트 모이어티를 포함하는 올리고머성 화합물은 특정 세포 유형에 의해 더 양호하게 차지되지만, 일단 올리고머성 화합물이 차지되면, 컨쥬게이트 그룹이 컨쥬게이션되지 않은 또는 모 올리고뉴클레오타이드를 방출시키기 위해 절단되는 것이 바람직하다. 따라서, 특정 컨쥬게이트 링커는 하나 이상의 절단가능한 모이어티를 포함할 수 있다. 특정 구현예에서, 절단가능한 모이어티는 절단가능한 결합이다. 특정 구현예에서, 절단가능한 모이어티는 적어도 하나의 절단가능한 결합을 포함하는 원자의 그룹이다. 특정 구현예에서, 절단가능한 모이어티는 1, 2, 3, 4, 또는 4개 초과 절단가능한 결합을 가지고 있는 원자의 그룹을 포함한다. 특정 구현예에서, 절단가능한 모이어티는 세포 또는 세포하 구획, 예컨대 리소좀 내부에서 선택적으로 절단된다. 특정 구현예에서, 절단가능한 모이어티는 내인성 효소, 예컨대 뉴클레아제에 의해 선택적으로 절단된다.
특정 구현예에서, 절단가능한 결합은 하기중으로부터 선택된다: 아미드, 에스테르, 에테르, 포스포디에스테르의 한쪽 또는 양쪽 에스테르, 포스페이트 에스테르, 카바메이트, 또는 디설파이드. 특정 구현예에서, 절단가능한 결합은 포스포디에스테르의 에스테르의 한쪽 또는 양쪽이다. 특정 구현예에서, 절단가능한 모이어티는 포스페이트 또는 포스포디에스테르를 포함한다. 특정 구현예에서, 절단가능한 모이어티는 올리고뉴클레오타이드와 컨쥬게이트 모이어티 또는 컨쥬게이트 그룹 사이 포스페이트 연결기이다.
특정 구현예에서, 절단가능한 모이어티는 하나 이상의 링커-뉴클레오사이드를 포함하거나 상기로 이루어진다. 특정 상기 구현예에서, 하나 이상의 링커-뉴클레오사이드는 절단가능한 결합을 통해 올리고머성 화합물의 서로에 및/또는 나머지에 연결된다. 특정 구현예에서, 그와 같은 절단가능한 결합은 미변형된 포스포디에스테르 결합이다. 특정 구현예에서, 절단가능한 모이어티는 포스페이트 인터뉴클레오사이드 연결기에 의해 올리고뉴클레오타이드의 3' 또는 5'-말단 뉴클레오사이드 어느 한쪽에 부착되는 그리고 포스페이트 또는 포스포로티오에이트 연결기에 의해 컨쥬게이트 링커 또는 컨쥬게이트 모이어티의 나머지에 공유적으로 부착되는 2'-데옥시 뉴클레오사이드이다. 특정 상기 구현예에서, 절단가능한 모이어티는 2'-데옥시아데노신이다.
B.
특정 말단기
특정 구현예에서, 올리고머성 화합물은 하나 이상의 말단기를 포함한다. 특정 상기 구현예에서, 올리고머성 화합물은 안정화된 5'-포페이트를 포함한다. 안정화된 5'-포스페이트는, 비제한적으로, 5'-비닐포스포네이트를 포함하는, 비제한적으로 5'-포스파네이트를 포함한다. 특정 구현예에서, 말단기는 하나 이상의 무염기성 뉴클레오사이드 및/또는 역 뉴클레오사이드를 포함한다. 특정 구현예에서, 말단기는 하나 이상의 2'-연결된 뉴클레오사이드를 포함한다. 특정 상기 구현예에서, 2'-연결된 뉴클레오사이드는 무염기성 뉴클레오사이드이다.
III.
올리고머성 듀플렉스
특정 구현예에서, 본 명세서에 기재된 올리고머성 화합물은, 표적 핵산의 것에 상보성인 핵염기 서열을 가지고 있는, 올리고뉴클레오타이드를 포함한다. 특정 구현예에서, 올리고머성 화합물은 올리고머성 듀플렉스를 형성하기 위해 제2 올리고머성 화합물과 짝짓기된다. 그와 같은 올리고머성 듀플렉스는 표적 핵산에 상보성인 영역을 가지고 있는 제1 올리고머성 화합물 그리고 제1 올리고머성 화합물에 상보성인 영역을 가지고 있는 제2 올리고머성 화합물을 포함한다. 특정 구현예에서, 올리고머성 듀플렉스의 제1 올리고머성 화합물은 (1) 변형된 또는 미변형된 올리고뉴클레오타이드 및 임의로 컨쥬게이트 그룹 그리고 (2) 제2 변형된 또는 미변형된 올리고뉴클레오타이드 및 임의로 컨쥬게이트 그룹을 포함하거나 상기로 이루어진다. 올리고머성 듀플렉스의 올리고머성 화합물 어느 한쪽 또는 양쪽은 컨쥬게이트 그룹을 포함할 수 있다. 올리고머성 듀플렉스의 각 올리고머성 화합물의 올리고뉴클레오타이드는 비-상보성 돌출형 뉴클레오사이드를 포함할 수 있다.
IV.
안티센스 활성
특정 구현예에서, 올리고머성 화합물 및 올리고머성 듀플렉스는, 적어도 하나의 안티센스 활성을 초래하는, 표적 핵산에 하이브리드화할 수 있고; 그와 같은 올리고머성 화합물 및 올리고머성 듀플렉스는 안티센스 화합물이다. 특정 구현예에서, 안티센스 화합물은 이들이 표준 세포 검정에서 25% 이상만큼 표적 핵산의 양 또는 활성을 감소 또는 억제시키는 경우 안티센스 활성을 가지고 있다. 특정 구현예에서, 안티센스 화합물은 하나 이상의 표적 핵산에 선택적으로 영향을 미친다. 그와 같은 안티센스 화합물은, 하나 이상의 원하는 안티센스 활성을 초래하는, 하나 이상의 표적 핵산에 하이브리드화하는 그리고 상당한 원하지 않는 안티센스 활성을 초래하는 방식으로 하나 이상의 비-표적 핵산에 하이브리드화하지 않거나 하나 이상의 비-표적 핵산에 하이브리드화하지 않는 핵염기 서열을 포함한다.
특정 안티센스 활성에서, 표적 핵산에 안티센스 화합물의 하이브리드화는 표적 핵산을 절단시키는 단백질의 동원을 초래한다. 예를 들어, 특정 안티센스 화합물은 표적 핵산의 RNase H 매개된 절단을 초래한다. RNase H는 RNA:DNA 듀플렉스의 RNA 가닥을 절단시키는 세포성 엔도뉴클레아제이다. 그와 같은 RNA:DNA 듀플렉스에서 DNA는 미변형된 DNA일 필요는 없다. 특정 구현예에서, RNase H 활성을 유도하기 위해 충분히 "DNA-유사"인 안티센스 화합물은 본 명세서에 기재된다. 특정 구현예에서, 갭머의 갭에서 하나 이상의 비-DNA-유사 뉴클레오사이드는 용인된다.
특정 안티센스 활성에서, 안티센스 화합물 또는 안티센스 화합물의 일 부분은 RNA-유도된 사일런싱 복합체 (RISC)에 장입되어, 궁극적으로 표적 핵산의 절단을 초래한다. 예를 들어, 특정 안티센스 화합물은 아르고노트에 의해 표적 핵산의 절단을 초래한다. RISC 속에 장입되는 안티센스 화합물은 RNAi 화합물이다. RNAi 화합물은 이중가닥 (siRNA) 또는 단일가닥 (ssRNA)일 수 있다.
특정 구현예에서, 표적 핵산에 안티센스 화합물의 하이브리드화는 그 표적 핵산을 절단하는 단백질의 동원을 초래하지 않는다. 특정 구현예에서, 표적 핵산에 안티센스 화합물의 하이브리드화는 표적 핵산의 스플라이싱의 변경을 초래한다. 특정 구현예에서, 표적 핵산에 안티센스 화합물의 하이브리드화는 표적 핵산과 단백질 또는 다른 핵산 사이 결합 상호작용의 억제를 초래한다. 특정 구현예에서, 표적 핵산에 안티센스 화합물의 하이브리드화는 표적 핵산의 번역의 변경을 초래한다.
안티센스 활성은 직접적으로 또는 간접적으로 관찰될 수 있다. 특정 구현예에서, 안티센스 활성의 관찰 또는 검출은 표적 핵산 또는 상기 표적 핵산에 의해 인코딩된 단백질의 양에서의 변화, 핵산 또는 단백질의 스플라이스 변이체의 비율에서의 변화 및/또는 세포 또는 동물에서 표현형 변화의 관찰 또는 검출을 포함한다.
V.
특정 표적 핵산
특정 구현예에서, 올리고머성 화합물은 표적 핵산에 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 상기로 이루어진다. 특정 구현예에서, 표적 핵산은 내인성 RNA 분자이다. 특정 구현예에서, 표적 핵산은 단백질을 인코딩한다. 특정 상기 구현예에서, 표적 핵산은 하기로부터 선택된다: 인트론, 엑손 및 미번역된 영역을 포함하는, 성숙 mRNA 및 pre-mRNA. 특정 구현예에서, 표적 RNA는 성숙 mRNA이다. 특정 구현예에서, 표적 핵산은 pre-mRNA이다. 특정 상기 구현예에서, 표적 영역은 전적으로 인트론 안에 있다. 특정 구현예에서, 표적 영역은 인트론/엑손 접합을 미친다. 특정 구현예에서, 표적 영역은 인트론 내에서 적어도 50%이다. 특정 구현예에서, 표적 핵산은 레트로진의 RNA 전사적 산물이다. 특정 구현예에서, 표적 핵산은 비-코딩 RNA이다. 특정 상기 구현예에서, 표적 비-코딩 RNA는 하기로부터 선택된다: 긴 비-코딩 RNA, 짧은 비-코딩 RNA, 인트론 RNA 분자.
A.
표적 핵산에 대한 상보성/미스매치
활성 제거 없이 미스매치 염기를 도입하는 것은 가능하다. 예를 들어, Gautschi 등 (J. Natl. Cancer Inst. 93:463-471, March 2001)은 시험관내 및 생체내 bcl-2 및 bcl-xL 둘 모두의 발현을 감소시키기 위해 bcl-xL mRNA에 3개의 미스매치를 가지고 있는 그리고 bcl-2 mRNA에 100% 상보성을 가지고 있는 올리고뉴클레오타이드의 활성을 증명하였다. 게다가, 이 올리고뉴클레오타이드는 생체내 잠재적 항-종양 활성을 증명하였다. Maher 및 Dolnick (Nuc. Acid. Res. 16:3341-3358, 1988)은, 토끼 망상적혈구 검정에서 인간 DHFR의 번역을 정지시키기 위한 그들의 능력에 대하여, 2 또는 3개의 탬덤 올리고뉴클레오타이드의 서열, 각각으로 구성된 28 및 42개 핵염기 올리고뉴클레오타이드, 그리고 탠덤 14개 핵염기 올리고뉴클레오타이드의 시리즈를 시험하였다. 각 3개의 14개 핵염기 올리고뉴클레오타이드 단독은 28 또는 42개 핵염기 올리고뉴클레오타이드보다 더 많은 적절한 수준에서이지만, 번역을 억제시킬 수 있었다.
특정 구현예에서, 올리고뉴클레오타이드는 올리고뉴클레오타이드의 전체 길이에 걸쳐 표적 핵산에 상보성이다. 특정 구현예에서, 올리고뉴클레오타이드는 표적 핵산에 99%, 95%, 90%, 85%, 또는 80% 상보성이다. 특정 구현예에서, 올리고뉴클레오타이드는 올리고뉴클레오타이드의 전체 길이에 걸쳐 표적 핵산에 적어도 80% 상보성이고 표적 핵산에 100% 또는 완전하게 상보성인 영역을 포함한다. 특정 구현예에서, 완전한 상보성의 영역은 6 내지 20, 10 내지 18, 또는 18 내지 20개 핵염기 길이이다.
특정 구현예에서, 올리고뉴클레오타이드는 표적 핵산에 비하여 하나 이상의 미스매치된 핵염기를 포함한다. 특정 구현예에서, 표적에 대한 안티센스 활성은 그와 같은 미스매치만큼 감소되지만, 비-표적에 대한 활성은 더 큰 양만큼 감소된다. 따라서, 특정 구현예에서 올리고뉴클레오타이드의 선택성은 개선된다. 특정 구현예에서, 미스매치는 갭머 모티프를 가지고 있는 올리고뉴클레오타이드 내에서 특이적으로 위치한다. 특정 구현예에서, 미스매치는 갭 영역의 5'-말단으로부터 1, 2, 3, 4, 5, 6, 7, 또는 8번 위치에 있다. 특정 구현예에서, 미스매치는 갭 영역의 3'-말단으로부터 9, 8, 7, 6, 5, 4, 3, 2, 1번 위치에 있다. 특정 구현예에서, 미스매치는 윙 영역의 5'-말단으로부터 1, 2, 3, 또는 4번 위치에 있다. 특정 구현예에서, 미스매치는 윙 영역의 3'-말단으로부터 4, 3, 2, 또는 1번 위치에 있다.
B.
LRRK2
특정 구현예에서, 올리고머성 화합물은 표적 핵산에 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 상기로 이루어지고, 여기서 상기 표적 핵산은 LRRK2이다. 특정 구현예에서, LRRK2 핵산은 서열번호: 1 (유전자은행 기탁 번호: NM_198578.3) 및 서열번호: 2 (뉴클레오타이드 2759000 내지 2909000으로부터 절단된 유전자은행 기탁 번호 : NT_029419.11)에서 제시된 서열을 가지고 있다.
특정 구현예에서, 서열번호: 1 또는 서열번호: 2에 상보성인 올리고머성 화합물과 세포의 접촉은 LRRK2 RNA의 양을 감소시키고, 특정 구현예에서 LRRK2 단백질의 양을 감소시킨다. 특정 구현예에서, 올리고머성 화합물은 변형된 올리고뉴클레오타이드로 이루어진다. 특정 구현예에서, 서열번호: 1 또는 서열번호: 2에 상보성인 올리고머성 화합물과 세포의 접촉은 신경퇴행성 질환의 하나 이상의 징후 또는 특징을 개선한다. 특정 구현예에서, 올리고머성 화합물은 변형된 올리고뉴클레오타이드로 이루어진다. 특정 구현예에서, 징후 또는 특징은 운동실조증, 신경병증, 및 응집체 형성이다. 특정 구현예에서, 서열번호: 1 또는 서열번호: 2에 상보성인 변형된 올리고뉴클레오타이드와 세포의 접촉은 개선된 운동 기능, 감소된 신경병증, 및 응집체의 수에서의 감소를 초래한다. 특정 구현예에서, 올리고머성 화합물은 변형된 올리고뉴클레오타이드로 이루어진다.
C.
특정 조직내 특정 표적 핵산
특정 구현예에서, 올리고머성 화합물은 표적 핵산에 상보성인 영역을 포함하는 올리고뉴클레오타이드를 포함하거나 상기로 이루어지고, 여기서 상기 표적 핵산은 약리학적으로 관련 조직에서 발현된다. 특정 구현예에서, 약리학적으로 관련 조직은 중추 신경계 (CNS)를 포함하는 조직 및 세포이다. 그와 같은 조직은 뇌조직, 예컨대, 대뇌피질, 흑질, 선조체, 중뇌, 및 뇌간 그리고 척수를 포함한다.
VI.
특정 약제학적 조성물
특정 구현예에서, 하나 이상의 올리고머성 화합물을 포함하는 약제학적 조성물은 본 명세서에 기재된다. 특정 구현예에서, 하나 이상의 올리고머성 화합물 각각은 변형된 올리고뉴클레오타이드로 이루어진다. 특정 구현예에서, 약제학적 조성물은 약제학적으로 허용가능한 희석제 또는 담체를 포함한다. 특정 구현예에서, 약제학적 조성물은 멸균 염수 용액 및 하나 이상의 올리고머성 화합물을 포함하거나 상기로 이루어진다. 특정 구현예에서, 멸균 염수는 약제학적 등급 염수이다. 특정 구현예에서, 약제학적 조성물은 하나 이상의 올리고머성 화합물 및 멸균수를 포함하거나 상기로 이루어진다. 특정 구현예에서, 멸균수는 약품 등급 물이다. 특정 구현예에서, 약제학적 조성물은 하나 이상의 올리고머성 화합물 및 포스페이트-완충 염수 (PBS)를 포함하거나 상기로 이루어진다. 특정 구현예에서, 멸균 PBS는 약품 등급 PBS이다. 특정 구현예에서, 약제학적 조성물은 하나 이상의 올리고머성 화합물 및 인공 뇌척수액을 포함하거나 상기로 이루어진다. 특정 구현예에서, 인공 뇌척수액은 약품 등급이다.
특정 구현예에서, 약제학적 조성물은 변형된 올리고뉴클레오타이드 및 인공 뇌척수액을 포함한다. 특정 구현예에서, 약제학적 조성물은 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 이루어진다. 특정 구현예에서, 약제학적 조성물은 본질적으로 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 이루어진다. 특정 구현예에서, 인공 뇌척수액은 약품 등급이다.
특정 구현예에서, 약제학적 조성물은 하나 이상의 올리고머성 화합물 및 하나 이상의 부형제를 포함한다. 특정 구현예에서, 부형제는 물, 염 용액, 알코올, 폴리에틸렌 글리콜, 젤라틴, 락토스, 아밀라제, 스테아르산마그네슘, 탈크, 규산, 점성 파라핀, 하이드록시메틸셀룰로스 및 폴리비닐피롤리돈으로부터 선택된다.
특정 구현예에서, 올리고머성 화합물은 약제학적 조성물 또는 제형의 제조를 위하여 약제학적으로 허용가능한 활성 및/또는 불활성 서브스턴스와 혼합될 수 있다. 조성물 및 약제학적 조성물의 제형화 방법은, 비제한적으로, 투여의 경로, 질환의 정도, 또는 투여되어야 하는 용량을 포함하여, 다수의 기준에 의존한다.
특정 구현예에서, 올리고머성 화합물을 포함하는 약제학적 조성물은 올리고머성 화합물의 임의의 약제학적으로 허용가능한 염, 올리고머성 화합물의 에스테르, 또는 상기 에스테르의 염을 포괄한다. 특정 구현예에서, 인간을 포함하는, 동물에 투여시, 하나 이상의 올리고뉴클레오타이드를 포함하는 올리고머성 화합물을 포함하는 약제학적 조성물은 생물학적으로 활성 대사물질 또는 이의 잔여물을 (직접적으로 또는 간접적으로) 제공할 수 있다. 따라서, 예를 들어, 본 개시내용은 또한 올리고머성 화합물의 약제학적으로 허용가능한 염, 전구약물, 상기 전구약물의 약제학적으로 허용가능한 염, 및 기타 생물동등물로 그려진다. 적당한 약제학적으로 허용가능한 염은, 비제한적으로, 나트륨 및 칼륨 염을 포함한다. 특정 구현예에서, 전구약물은 올리고뉴클레오타이드에 부착된 하나 이상의 컨쥬게이트 그룹을 포함하고, 여기서 상기 컨쥬게이트 그룹은 바디 내에서 내인성 뉴클레아제에 의해 절단된다.
지질 모이어티는 다양한 방법에서 핵산 요법에 사용되어 왔다. 특정 상기 방법에서, 핵산, 예컨대 올리고머성 화합물은 양이온성 지질 및 중성 지질의 혼합물로 만들어진 사전형성된 리포좀 또는 리포플렉스 속에 도입된다. 특정 방법에서, 모노- 또는 폴리-양이온성 지질을 가진 DNA 복합체는 중성 지질의 존재 없이 형성된다. 특정 구현예에서, 지질 모이어티는 특정 세포 또는 조직에 약제학적 제제의 분포를 증가시키도록 선택된다. 특정 구현예에서, 지질 모이어티는 지방 조직에 약제학적 제제의 분포를 증가시키도록 선택된다. 특정 구현예에서, 지질 모이어티는 근육 조직에 약제학적 제제의 분포를 증가시키도록 선택된다.
특정 구현예에서, 약제학적 조성물은 전달 시스템을 포함한다. 전달 시스템의 예는, 비제한적으로, 리포좀 또는 유탁액을 포함한다. 특정 전달 시스템은 소수성 화합물을 포함하는 것을 포함하는 특정 약제학적 조성물 제조에 유용하다. 특정 구현예에서, 특정 유기 용매 예컨대 디메틸설폭사이드는 사용된다.
특정 구현예에서, 약제학적 조성물은 특이적 조직 또는 세포 유형에 본 발명의 하나 이상의 약제학적 제제를 전달하도록 설계된 하나 이상의 조직-특이적 전달 분자를 포함한다. 예를 들어, 특정 구현예에서, 약제학적 조성물은 조직-특이적 항체로 코팅된 리포좀을 포함한다.
특정 구현예에서, 약제학적 조성물은 공-용매 시스템을 포함한다. 특정한 상기 공-용매 시스템은, 예를 들어, 벤질 알코올, 무극성 계면활성, 수혼화성 유기 폴리머, 및 수상을 포함한다. 특정 구현예에서, 상기 공-용매 시스템은 소수성 화합물에 사용된다. 상기 공-용매 시스템의 비-제한 예는 VPD 공-용매 시스템이고, 이는 3% w/v 벤질 알코올, 8% w/v의 무극성 계면활성제 Polysorbate 80™ 및 65% w/v 폴리에틸렌 글리콜 300을 포함하는 무수 에탄올의 용액이다. 상기 공-용매 시스템의 분율은 그들의 용해성 및 독성 특성의 유의미한 변경 없이 상당히 다양할 수 있다. 게다가, 공-용매 성분의 정체성은 다양할 수 있다: 예를 들어, 다른 계면활성제는 Polysorbate 80™ 대신 사용될 수 있고; 폴리에틸렌 글리콜의 분획 크기는 다양할 수 있고; 다른 생물적합성 폴리머는 폴리에틸렌 글리콜, 예를 들면, 폴리비닐 피롤리돈을 대체할 수 있고; 다른 당 또는 폴리사카라이드는 덱스트로스를 대신할 수 있다.
특정 구현예에서, 약제학적 조성물은 경구 투여를 위하여 제조된다. 특정 구현예에서, 약제학적 조성물은 구강 투여를 위하여 제조된다. 특정 구현예에서, 약제학적 조성물은 주사로 (예를 들면, 정맥내, 피하, 근육내, 척추강내 (IT), 뇌실내 (ICV), 등) 투여를 위하여 제조된다. 특정한 상기 구현예에서, 약제학적 조성물은 담체를 포함하고 수용액, 예컨대 물 또는 생리학적으로 상용성 완충액 예컨대 항크스액, 링거액, 또는 생리학적 염수 완충액에서 제형화된다. 특정 구현예에서, 다른 재료 (예를 들면, 용해성을 돕거나 보존제로서 작용하는 재료)는 포함된다. 특정 구현예에서, 주사가능한 현탁액은 적당한 액체 담체, 현탁제 및 기타 등등을 사용하여 제조된다. 주사용 특정 약제학적 조성물은 단위 투약량 형태, 예를 들면, 앰풀 또는 다-용량 컨테이너로 제시된다. 주사용 특정 약제학적 조성물은 유성 또는 수성 비히클에서 현탁액, 용액 또는 유탁액이고, 제형성 제제 예컨대 현탁제, 안정화제 및/또는 분산제를 함유할 수 있다. 주사용 약제학적 조성물에서 사용에 적당한 특정 용매는, 비제한적으로, 친유성 용매 및 지방 오일, 에컨대 참깨 오일, 합성 지방산 에스테르, 예컨대 에틸 올레에이트 또는 트리글리세라이드, 및 리포좀을 포함한다.
특정 조건 하에서, 본 명세서에 개시된 특정 화합물은 산으로서 작용한다. 그와 같은 화합물이 양성화된 (자유 산) 형태로, 이온화된 (음이온) 형태로, 또는 이온화되고 양이온 (염) 형태와 회합으로 그려질 수 있거나 기재될 수 있어도, 그와 같은 화합물의 수용액은 그와 같은 형태 중에서 평형상태로 실존한다. 예를 들어, 수용액내 올리고뉴클레오타이드의 포스페이트 연결기는 자유 산, 음이온, 및 염 형태 중에서 평형상태로 실존한다. 달리 나타내지 않는 한, 본 명세서에 기재된 화합물은 모든 그와 같은 형태를 포함하기 위한 것이다. 더욱이, 특정 올리고뉴클레오타이드는 몇몇 그와 같은 연결기를 가지고 있고, 이들 각각은 평형상태이다. 따라서, 용액내 올리고뉴클레오타이드는 평형상태로 다중 위치 모두에서 형태의 앙상블로 실존한다. 용어 "올리고뉴클레오타이드"는 모든 그와 같은 형태를 포함하기 위한 것이다. 작도된 구조는 반드시 단일 형태를 묘사한다. 그럼에도 불구하고, 달리 나타내지 않는 한, 그와 같은 도면은 마찬가지로 상응하는 형태를 포함하기 위한 것이다. 본 명세서에, 용어 "또는 이의 염"이 뒤따르는 화합물의 자유 산을 묘사하는 구조는 완전하게 또는 부분적으로 양성화/탈-양성화/양이온과 회합될 수 있는 모든 그와 같은 형태를 명백히 포함한다. 특정 사례에서, 하나 이상의 구체적 양이온은 확인된다.
특정 구현예에서, 본 명세서에 개시된 올리고머성 화합물은 나트륨을 가진 수용액에 있다. 특정 구현예에서, 올리고머성 화합물은 칼륨을 가진 수용액에 있다. 특정 구현예에서, 올리고머성 화합물은 인위적 CSF에 있다. 특정 구현예에서, 올리고머성 화합물은 PBS에 있다. 특정 구현예에서, 올리고머성 화합물은 물에 있다. 특정 상기 구현예에서, 용액의 pH는 원하는 pH를 달성하기 위해 NaOH 및/또는 HCl로 조정된다.
VII.
특정 조성물
1. 화합물 번호: 780241
화합물 번호: 780241은, (서열번호: 222로서 본 명세서에 편입된) (5'부터 3'까지) GCTCATATCTAAAGACCGCA의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3, 3 내지 4, 4 내지 5, 16 내지 17, 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 780241은 하기 화학 표기법으로 특성규명될 수 있다: Ges mCeo Teo mCeo Aes Tds Ads Tds mCds Tds Ads Ads Ads Gds Ads mCeo mCeo Ges mCes Ae; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 780241은 하기 화학 구조로 나타낼 수 있다:
구조 1. 화합물 번호: 780241
(서열번호: 222).
화합물 번호: 780241은 하기 화학 구조로 나타낼 수 있다:
구조 2. 화합물 번호: 780241의 나트륨 염
(서열번호: 222).
2. 화합물 번호: 802714
화합물 번호: 802714는, (서열번호: 888로서 본 명세서에 편입된) (5'부터 3'까지) TCACCACAAACTCATGGACT의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3, 3 내지 4, 4 내지 5, 16 내지 17, 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 802714는 하기 화학 표기법으로 특성규명될 수 있다: Tes mCeo Aeo mCeo mCes Ads mCds Ads Ads Ads mCds Tds mCds Ads Tds Geo Geo Aes mCes Te; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 802714는 하기 화학 구조로 나타낼 수 있다:
구조 3. 화합물 번호: 802714
(서열번호: 888).
화합물 번호: 802714는 하기 화학 구조로 나타낼 수 있다:
구조 4. 화합물 번호: 802714의 나트륨 염
(서열번호: 888).
3. 화합물 번호: 803268
화합물 번호: 803268은, (서열번호: 1431로서 본 명세서에 편입된) (5'부터 3'까지) ACCCTTTCCATGTGAACATT의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3, 3 내지 4, 4 내지 5, 16 내지 17, 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 803268은 하기 화학 표기법으로 특성규명될 수 있다: Aes mCeo mCeo mCeo Tes Tds Tds mCds mCds Ads Tds Gds Tds Gds Ads Aeo mCeo Aes Tes Te; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 803268은 하기 화학 구조로 나타낼 수 있다:
구조 5. 화합물 번호: 803268
(서열번호: 1431).
화합물 번호: 803268은 하기 화학 구조로 나타낼 수 있다:
구조 6. 화합물 번호: 803268의 나트륨 염
(서열번호: 1431).
4. 화합물 번호: 876031
화합물 번호: 876031은, (서열번호: 3590으로서 본 명세서에 편입된) (5'부터 3'까지) ACGCACTTAACAATATCATA의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3, 3 내지 4, 4 내지 5, 16 내지 17, 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 876031은 하기 화학 표기법으로 특성규명될 수 있다: Aes mCeo Geo mCeo Aes mCds Tds Tds Ads Ads mCds Ads Ads Tds Ads Teo mCeo Aes Tes Ae; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 876031은 하기 화학 구조로 나타낼 수 있다:
구조 7. 화합물 번호: 876031
(서열번호: 3590).
화합물 번호: 876031은 하기 화학 구조로 나타낼 수 있다:
구조 8. 화합물 번호: 876031의 나트륨 염
(서열번호: 3590).
5. 화합물 번호: 876604
화합물 번호: 876604는, (서열번호: 3385로서 본 명세서에 편입된) (5'부터 3'까지) AGCAATCATTGGTAGCATAC의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3, 3 내지 4, 4 내지 5, 16 내지 17, 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 876604는 하기 화학 표기법으로 특성규명될 수 있다: Aes Geo mCeo Aeo Aes Tds mCds Ads Tds Tds Gds Gds Tds Ads Gds mCeo Aeo Tes Aes mCe; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 876604는 하기 화학 구조로 나타낼 수 있다:
구조 8. 화합물 번호: 876604
(서열번호: 3385).
화합물 번호: 876604는 하기 화학 구조로 나타낼 수 있다:
구조 10. 화합물 번호: 876604의 나트륨 염
(서열번호: 3385).
6. 화합물 번호: 934556
화합물 번호: 934556은, (서열번호: 852로서 본 명세서에 편입된) (5'부터 3'까지) CGCACTTAACAATATCATAT의 서열을 가지고 있는, 5-10-5 MOE 갭머로서 특성규명될 수 있고, 여기서 각각의 뉴클레오사이드 1-5 및 16-20 (5'부터 3'까지)는 2'-MOE 변형을 포함하고 각각의 뉴클레오사이드 6-15는 2'-데옥시뉴클레오사이드이고, 여기서 뉴클레오사이드 2 내지 3 및 17 내지 18 사이 인터뉴클레오사이드 연결기는 포스포디에스테르 인터뉴클레오사이드 연결기이고 뉴클레오사이드 1 내지 2, 3 내지 4, 4 내지 5, 5 내지 6, 6 내지 7, 7 내지 8, 8 내지 9, 9 내지 10, 10 내지 11, 11 내지 12, 12 내지 13, 13 내지 14, 14 내지 15, 15 내지 16, 16 내지 17, 18 내지 19, 및 19 내지 20 사이 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고, 상기 각 시토신은 5-메틸 시토신이다.
화합물 번호: 934556은 하기 화학 표기법으로 특성규명될 수 있다: mCes Geo mCes Aes mCes Tds Tds Ads Ads mCds Ads Ads Tds Ads Tds mCes Aeo Tes Aes Te; 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
화합물 번호: 934556은 하기 화학 구조로 나타낼 수 있다:
구조 11. 화합물 번호: 934556
(서열번호: 852).
화합물 번호: 934556은 하기 화학 구조로 나타낼 수 있다:
구조 12. 화합물 번호: 934556의 나트륨 염
(서열번호: 852).
VIII. 특정 핫스팟 영역
1. 서열번호: 2의 핵염기 18,633-18,658
특정 구현예에서, 서열번호: 2의 핵염기 18,633-18,658은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 18,633-18,658에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 18,633-18,658에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 852, 1997, 2073, 2148, 3513, 및 3590의 핵염기 서열은 서열번호: 2의 핵염기 18,633-18,658에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 18,633-18,658에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 54% 감소를 달성한다.
2. 서열번호: 2의 핵염기 21,721-21,755
특정 구현예에서, 서열번호: 2의 핵염기 21,721-21,755는 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 21,721-21,755에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 21,721-21,755에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 291, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 및 880의 핵염기 서열은 서열번호: 2의 핵염기 21,721-21,755에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 21,721-21,755에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 52% 감소를 달성한다.
3. 서열번호: 2의 핵염기 27,963-28,016
특정 구현예에서, 서열번호: 2의 핵염기 27,963-28,016은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 27,963-28,016에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 27,963-28,016에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 293, 886, 887, 888, 889, 890, 891, 892, 893, 및 3745의 핵염기 서열은 서열번호: 2의 핵염기 27,963-28,016에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 27,963-28,016에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 39% 감소를 달성한다.
4. 서열번호: 2의 핵염기 35,415-35,446
특정 구현예에서, 서열번호: 2의 핵염기 35,415-35,446은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 35,415-35,446에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 35,415-35,446에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 920, 921, 2378, 2454, 2530, 2606, 2683, 2759, 2835, 3061, 3137, 3212, 및 3288의 핵염기 서열은 서열번호: 2의 핵염기 35,415-35,446에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 35,415-35,446에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 42% 감소를 달성한다.
5. 서열번호: 2의 핵염기 77,221-77,264
특정 구현예에서, 서열번호: 2의 핵염기 77,221-77,264는 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 77,221-77,264에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 77,221-77,264에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 131, 217, 1106, 1107, 및 1108의 핵염기 서열은 서열번호: 2의 핵염기 77,221-77,264에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 77,221-77,264에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 51% 감소를 달성한다.
6. 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869
특정 구현예에서, 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869는 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 667, 668, 669, 670, 671, 1785, 1786, 1787, 1788, 1789, 1790, 1791, 및 1792의 핵염기 서열은 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 81,581-81,612 및 87,838-87,869에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 38% 감소를 달성한다.
7. 서열번호: 2의 핵염기 81,627-81,651
특정 구현예에서, 서열번호: 2의 핵염기 81,627-81,651은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 81,627-81,651에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 81,627-81,651에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 674, 1799, 1800, 1801, 1802, 및 1803의 핵염기 서열은 서열번호: 2의 핵염기 81,627-81,651에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 81,627-81,651에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 66% 감소를 달성한다.
8. 서열번호: 2의 핵염기 82,058-82,081
특정 구현예에서, 서열번호: 2의 핵염기 82,058-82,081은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 82,058-82,081에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 82,058-82,081에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 222, 1130, 1131, 1132, 및 1133의 핵염기 서열은 서열번호: 2의 핵염기 82,058-82,081에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 82,058-82,081에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 53% 감소를 달성한다.
9. 서열번호: 2의 핵염기 82,180-82,220
특정 구현예에서, 서열번호: 2의 핵염기 82,180-82,220은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 82,180-82,220에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 82,180-82,220에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 225, 1145, 2005, 2840, 3369, 3446, 3521, 3598, 및 3674의 핵염기 서열은 서열번호: 2의 핵염기 82,180-82,220에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 82,180-82,220에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 64% 감소를 달성한다.
10. 서열번호: 2의 핵염기 82,500-82,525
특정 구현예에서, 서열번호: 2의 핵염기 82,500-82,525는 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 82,500-82,525에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 82,500-82,525에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 439, 1807, 1808, 1809, 1810, 1811, 및 1812의 핵염기 서열은 서열번호: 2의 핵염기 82,500-82,525에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 82,500-82,525에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 49% 감소를 달성한다.
11. 서열번호: 2의 핵염기 91,038-91,067
특정 구현예에서, 서열번호: 2의 핵염기 91,038-91,067은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 91,038-91,067에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 91,038-91,067에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 692, 1826, 1827, 1828, 1829, 1830, 1831, 1832, 1833, 1834, 및 1835의 핵염기 서열은 서열번호: 2의 핵염기 91,038-91,067에 상보성이다.
화합물 번호: 780642, 803664, 803665, 803666, 803667, 803668, 803669, 803670, 803671, 803672, 및 803673의 변형된 올리고뉴클레오타이드는 서열번호: 2의 뉴클레오타이드 91,038-91,067에 대해 상보적이다.
특정 구현예에서, 서열번호: 2의 핵염기 91,038-91,067에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 42% 감소를 달성한다.
12. 서열번호: 2의 핵염기 92,148-92,173
특정 구현예에서, 서열번호: 2의 핵염기 92,148-92,173은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 92,148-92,173에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 92,148-92,173에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 1213, 2613, 2690, 3143, 3219, 및 3295의 핵염기 서열은 서열번호: 2의 핵염기 92,148-92,173에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 92,148-92,173에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 59% 감소를 달성한다.
13. 서열번호: 2의 핵염기 98,186-98,220
특정 구현예에서, 서열번호: 2의 핵염기 98,186-98,220은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 98,186-98,220에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 98,186-98,220에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 1231, 1232, 2462, 2538, 2614, 2691, 2767, 3069, 3144, 3220, 3296의 핵염기 서열은 서열번호: 2의 핵염기 98,186-98,220에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 98,186-98,220에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 55% 감소를 달성한다.
14. 서열번호: 2의 핵염기 98,218-98,242
특정 구현예에서, 서열번호: 2의 핵염기 98,218-98,242는 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 98,218-98,242에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 98,218-98,242에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 150, 1233, 2008, 3372, 3449, 및 3524의 핵염기 서열은 서열번호: 2의 핵염기 98,218-98,242에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 98,218-98,242에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 38% 감소를 달성한다.
15. 서열번호: 2의 핵염기 99,199-99,223
특정 구현예에서, 서열번호: 2의 핵염기 99,199-99,223은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 99,199-99,223에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 99,199-99,223에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 1243, 2311, 2387, 2920, 2995, 및 3755의 핵염기 서열은 서열번호: 2의 핵염기 99,199-99,223에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 99,199-99,223에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 52% 감소를 달성한다.
16. 서열번호: 2의 핵염기 119,903-119,936
특정 구현예에서, 서열번호: 2의 핵염기 119,903-119,936은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 2의 핵염기 119,903-119,936에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 119,903-119,936에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 750, 1927, 1928, 1929, 1930, 1931, 1932, 1933, 1934, 1935, 2822, 2898, 3351, 및 3733의 핵염기 서열은 서열번호: 2의 핵염기 119,903-119,936에 상보성이다.
특정 구현예에서, 서열번호: 2의 핵염기 119,903-119,936에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 51% 감소를 달성한다.
17. 서열번호: 1의 핵염기 4,062-4,086
특정 구현예에서, 서열번호: 1의 핵염기 4,062-4,086은 핫스팟 영역을 포함한다. 특정 구현예에서, siRNAs는 서열번호: 1의 핵염기 4,062-4,086에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 서열번호: 1의 핵염기 4,062-4,086에 상보성이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 20개의 핵염기 길이이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머이다. 특정 구현예에서, 변형된 올리고뉴클레오타이드의 인터뉴클레오사이드 연결기는 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기이다. 특정 구현예에서, 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 인터뉴클레오사이드 연결기는 5'부터 3'까지의 순서로 배열된다: sooosssssssssssooss.
서열번호: 39, 231, 232, 233, 1161, 및 1162의 핵염기 서열은 서열번호: 1의 핵염기 4,062-4,086에 상보성이다.
특정 구현예에서, 서열번호: 1의 핵염기 4,062-4,086에 상보성인 변형된 올리고뉴클레오타이드는 적어도 하나의 단일 용량 검정에서 시험관내 LRRK2 RNA의 적어도 56% 감소를 달성한다.
비제한 개시내용 및 참고에 의한 편입
본 명세서에 열거된 각각의 문헌 및 특허 공보는 전체적으로 참고로 편입된다.
본 명세서에 기재된 특정 화합물, 조성물 및 방법이 특정 구현예에 따라 특이성으로 기재되어 오면서, 하기 실시예는 본 명세서에 기재된 화합물을 단지 설명하도록 작용하고 동일한 것을 제한하기 위한 것은 아니다. 본원에서 인용된 각각의 참고문헌, 유전자은행 기탁 번호, 및 기타 등등은 그 전체가 참고로 본 명세서에 편입된다.
본 출원에 첨부하는 서열 목록이 요구되는 바와 같이 어느 한쪽 "RNA" 또는 "DNA"로서 각 서열을 확인하여도, 실제로는, 그들 서열은 화학적 변형의 임의의 조합으로 변형될 수 있다. 당해 분야의 숙련가는 "RNA" 또는 "DNA"로서 그와 같은 지정이 임의의 특정 사례에서 변형된 올리고뉴클레오타이드를 기재한다는 것을 쉽게 인정할 것이다. 예를 들어, 2'-OH 당 모이어티 및 티민 염기를 포함하는 뉴클레오사이드를 포함하는 올리고뉴클레오타이드는 변형된 당 (DNA의 1개의 2'-H 대신 2'-OH)를 가지고 있는 DNA로서, 또는 변형된 염기 (RNA의 우라실 대신 티민 (메틸화된 우라실))을 가지고 있는 RNA로서 기재될 수 있다. 따라서, 비제한적으로 서열 목록에서의 것들을 포함하는, 본 명세서에 제공된 핵산 서열은, 비제한적으로 변형된 핵염기를 가지고 있는 그와 같은 핵산을 포함하는, 천연 또는 변형된 RNA 및/또는 DNA의 임의의 조합을 함유하는 핵산을 포괄하기 위한 것이다. 추가 예로서 및 제한 없이, 핵염기 서열 "ATCGATCG"를 가지고 있는 올리고머성 화합물은, 변형되든 또는 미변형되든, 비제한적으로, RNA 염기를 포함하는 그와 같은 화합물, 예컨대 서열 "AUCGAUCG"를 가지고 있는 것 및 일부 DNA 염기 및 일부 RNA 염기 예컨대 "AUCGATCG"를 가지고 있는 것을 포함하는, 그와 같은 핵염기 서열을 가지고 있는 임의의 올리고머성 화합물 그리고 다른 변형된 핵염기, 예컨대 "ATmCGAUCG" (여기서 mC는 5-위치에서 메틸 기를 포함하는 시토신 염기를 나타낸다)를 가지고 있는 올리고머성 화합물을 포괄한다.
본 명세서에 기재된 특정 화합물 (예를 들면, 변형된 올리고뉴클레오타이드)는 하나 이상의 비대칭 중심을 갖고 따라서, 절대적 입체화학 관점에서, (R) 또는 (S)로서, 예컨대 당 아노머에 대하여 α 또는 β로서, 또는 예컨대 아미노산에 대하여 (D) 또는 (L)로서, 정의될 수 있는 거울상이성질체, 부분입체이성질체, 및 다른 입체이성질체 배치형태, 등을 야기시킨다. 특정 입체이성질체 배치형태로 그려지는 또는 상기를 갖는 것으로서 기재되는 본 명세서에 제공된 화합물은 지시된 화합물만을 포함한다. 미정의된 입체화학으로 그려지는 또는 기재되는 본 명세서에 제공된 화합물은, 달리 특정되지 않는 한, 그것의 스테레오랜덤 및 광학적으로 순수한 형태를 포함하여, 모든 그와 같은 가능한 이성질체를 포함한다. 마찬가지로, 본 명세서에서 화합물의 호변이성질체 형태는 달리 나타내지 않는 한 또한 포함된다. 달리 나타내지 않는 한, 본 명세서에 기재된 화합물은 상응하는 염 형태를 포함하기 위한 것이다.
본 명세서에 기재된 화합물은 하나 이상의 원자가 지시된 원소의 비-방사성 동위원소 또는 방사성 동위원소로 대체되는 변동을 포함한다. 예를 들어, 수소 원자를 포함하는 본 명세서에서의 화합물은 각각의 1H 수소 원자에 대하여 모든 가능한 중수소 치환을 포괄한다. 본 명세서에서의 화합물에 의해 포괄된 동위원소 치환은 하기를 비제한적으로 포함한다: 1H 대신에 2H 또는 3H, 12C 대신에 13C 또는 14C, 14N 대신에 15N, 16O 대신에 17O 또는 18O, 및 32S 대신에 33S, 34S, 35S, 또는 36S. 특정 구현예에서, 비-방사성 동위원소 치환은 치료 또는 연구 도구로서 사용에 유익한 올리고머성 화합물에 신규한 특성을 부여할 수 있다. 특정 구현예에서, 방사성 동위원소 치환은 연구 또는 진단 목적 예컨대 이미지형성에 적당한 화합물을 만들 수 있다.
실시예
하기 실시예는 본 개시내용의 특정 구현예를 설명하고 비제한적이다. 더욱이, 특정 구현예가 제공되는 경우, 본 발명가는 그들 특정 구현예의 포괄적 적용을 고려하였다. 예를 들어, 특정 모티프를 가지고 있는 올리고뉴클레오타이드의 개시내용은 동일 또는 유사 모티프를 가지고 있는 추가의 올리고뉴클레오타이드를 지원한다. 그리고, 예를 들어, 특정 고-친화도 변형이 특정 위치에서 나타나는 경우, 동일 위치에서 다른 고-친화도 변형은, 달리 나타내지 않는 한, 적당히 고려된다.
실시예 1: 인간 LRRK2 RNA 발현
시험관내,
단일 용량에서 포스포로티오에이트 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
인간 LRRK2 핵산에 상보성인 변형된 올리고뉴클레오타이드는 시험관내 LRRK2 RNA에서 그것의 효과에 대하여 설계 및 시험되었다.
20,000 세포/웰의 밀도에서 배양된 SH-SY5Y 세포는 미처리된 대조군에 대하여 5,000 nM 농도의 변형된 올리고뉴클레오타이드로 또는 변형된 올리고뉴클레오타이드 없이 전기천공을 사용하여 형질감염되었다. 대략 24 시간 후, RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. 인간 프라이머 프로브 세트 RTS3133_MGB (정방향 서열 TTCCACACTTGCGGTCTTTAGA, 서열번호: 11로서 본 명세서에 지정됨; 역방향 서열 GCGGGACCTGGTAGGTACTG, 서열번호: 12로서 본 명세서에 지정됨; 프로브 서열 ATGAGCAGCAATGAT, 서열번호: 13으로서 본 명세서에 지정됨)은 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 별표 (*)로 표시된 퍼센트 대조군 값을 가진 변형된 올리고뉴클레오타이드는 프라이머 프로브 세트의 앰플리콘 영역을 표적화한다. 추가의 검정은 앰플리콘 영역을 표적화하는 올리고뉴클레오타이드의 효력 및 효능을 측정하는데 사용될 수 있다.
표 1에서 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 갭머는 20개의 핵염기 길이이고, 여기서 중심 갭 단편은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 5개의 2'-MOE 뉴클레오사이드를 포함하는 5' 말단 및 3' 말단 둘 모두에서 윙 단편에 의해 측접된다. 갭머용 당 모티프는 (5'부터 3'까지) 하기이고: eeeeeddddddddddeeeee; 여기서 'd'는 2'-데옥시리보오스 당을 나타내고 'e'는 2'-MOE 변형된 당을 나타낸다. 각 인터뉴클레오사이드 연결기는 포스포로티오에이트 인터뉴클레오사이드 연결기이고 각 시토신 잔기는 5-메틸 시토신이다. "개시 부위"는 갭머가 인간 핵산 서열에서 상보성인 5'-최말단 뉴클레오사이드를 나타낸다. "중단 부위"는 갭머가 인간 핵산 서열에서 상보성인 3'-최말단 뉴클레오사이드를 나타낸다.
표 1에서 열거된 각 변형된 올리고뉴클레오타이드는, 명시된 바와 같이, 인간 LRRK2 핵산 서열 서열번호: 1 또는 서열번호: 2에 상보성이다. 'N/A'는 변형된 올리고뉴클레오타이드가 100% 상보성을 가진 그 특정 핵산에 상보성이지 않다는 것을 나타낸다. 아래 나타난 바와 같이, 인간 LRRK2 RNA의 서열에 상보성인 변형된 올리고뉴클레오타이드는 인간 LRRK2 RNA의 양을 감소시켰다.
실시예 2: 인간 LRRK2 RNA 발현
시험관내
, 단일 용량에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
인간 LRRK2 핵산에 상보성인 변형된 올리고뉴클레오타이드는 시험관내 LRRK2 RNA에서 그것의 효과에 대하여 설계 및 시험되었다. 변형된 올리고뉴클레오타이드는 유사한 배양 조건을 가졌던 일련의 실험에서 시험되었다.
20,000 세포/웰의 밀도에서 배양된 SH-SY5Y 세포는 미처리된 대조군에 대하여 5,000 nM 농도의 변형된 올리고뉴클레오타이드로 또는 변형된 올리고뉴클레오타이드 없이 전기천공을 사용하여 형질감염되었다. 대략 24 시간 후, RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. 인간 프라이머 프로브 세트 RTS3132 (정방향 서열 CATCACTCAGGCTGTTAAGACAAGA, 서열번호: 14로서 본 명세서에 지정됨; 역방향 서열 CAGCTGCCAGCAAAGATATCAA, 서열번호: 15로서 본 명세서에 지정됨; 프로브 서열 CTTTGCCACCTCCACCACCCCA, 서열번호: 16으로서 본 명세서에 지정됨), RTS3133_MGB (정방향 서열 TTCCACACTTGCGGTCTTTAGA, 서열번호: 11로서 본 명세서에 지정됨; 역방향 서열 GCGGGACCTGGTAGGTACTG, 서열번호: 12로서 본 명세서에 지정됨; 프로브 서열 ATGAGCAGCAATGAT, 서열번호: 13으로서 본 명세서에 지정됨), 및 RTS3146_MGB (정방향 서열 GAGCTTCCTCACGCAGTTCAC, 서열번호: 17로서 본 명세서에 지정됨; 역방향 서열 TGCTGGGTCTTGAAAATGAAGA, 서열번호: 18로서 본 명세서에 지정됨; 프로브 서열 TTCTAAATGAATCAGGAGTCC, 서열번호: 19로서 본 명세서에 지정됨)은 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 대조군 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 별표 (*)로 표시된 퍼센트 대조군 값을 가진 변형된 올리고뉴클레오타이드는 프라이머 프로브 세트의 앰플리콘 영역을 표적화한다.
표 2에서 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 갭머는 20개의 핵염기 길이이고, 여기서 중심 갭 단편은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 5개의 2'-MOE 뉴클레오사이드를 포함하는 5' 말단 및 3' 말단 둘 모두에서 윙 단편에 의해 측접된다. 갭머용 당 모티프는 (5'부터 3'까지) 하기이고: eeeeeddddddddddeeeee; 여기서 'd'는 2'-데옥시리보오스 당을 나타내고 'e'는 2-MOE 변형된 당을 나타낸다. 각 갭머 전반에 걸쳐 모든 시토신 잔기는 5-메틸 시토신이다. 각 갭머용 인터뉴클레오사이드 연결기는 혼합된 포스포디에스테르 및 포스포로티오에이트 연결기이다. 갭머용 인터뉴클레오사이드 연결기 모티프는 (5'부터 3'까지) 하기이고: sooosssssssssssooss; 여기서 'o'는 포스포디에스테르 인터뉴클레오사이드 연결기를 나타내고 's'는 포스포로티오에이트 인터뉴클레오사이드 연결기를 나타낸다. "개시 부위"는 갭머가 인간 핵산 서열에서 상보성인 5'-최말단 뉴클레오사이드를 나타낸다. "중단 부위"는 갭머가 인간 핵산 서열에서 상보성인 3'-최말단 뉴클레오사이드를 나타낸다.
표 2에서 열거된 각 변형된 올리고뉴클레오타이드는, 명시된 바와 같이, 인간 LRRK2 핵산 서열 서열번호: 1 또는 서열번호: 2에 상보성이다. 'N/A'는 변형된 올리고뉴클레오타이드가 100% 상보성을 가진 그 특정 핵산 서열에 상보성이지 않다는 것을 나타낸다. 아래 나타난 바와 같이, 인간 LRRK2 RNA의 서열에 상보성인 변형된 올리고뉴클레오타이드는 인간 LRRK2 RNA의 양을 감소시켰다.
실시예 3: 인간 LRRK2 RNA 발현
시험관내
, 단일 용량에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
인간 LRRK2 핵산에 상보성인 변형된 올리고뉴클레오타이드는 시험관내 LRRK2 RNA에서 그것의 효과에 대하여 설계 및 시험되었다. 변형된 올리고뉴클레오타이드는 유사한 배양 조건을 가졌던 일련의 실험에서 시험되었다.
20,000 세포/웰의 밀도에서 배양된 SH-SY5Y 세포는 미처리된 대조군에 대하여 3,000 nM 농도의 변형된 올리고뉴클레오타이드로 또는 변형된 올리고뉴클레오타이드 없이 전기천공을 사용하여 형질감염되었다. 대략 24 시간 후, RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 실시예 2에서 기재된 바와 같이 인간 프라이머 프로브 세트 RTS3132를 사용하여 정량적 실시간 PCR에 의해 측정되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 별표 (*)로 표시된 퍼센트 대조군 값을 가진 변형된 올리고뉴클레오타이드는 프라이머 프로브 세트의 앰플리콘 영역을 표적화한다. 추가의 검정은 앰플리콘 영역을 표적화하는 올리고뉴클레오타이드의 효력 및 효능을 측정하는데 사용될 수 있다.
표 3-9에서 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 갭머는 20개의 핵염기 길이이고, 여기서 중심 갭 단편은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 5개의 2'-MOE 뉴클레오사이드를 포함하는 5' 말단 및 3' 말단 둘 모두에서 윙 단편에 의해 측접된다. 갭머용 당 모티프는 (5'부터 3'까지) 하기이고: eeeeeddddddddddeeeee; 여기서 'd'는 2'-데옥시리보오스 당을 나타내고 'e'는 2-MOE 변형된 당을 나타낸다. 각 갭머 전반에 걸쳐 모든 시토신 잔기는 5-메틸 시토신이다. 각 갭머용 인터뉴클레오사이드 연결기는 혼합된 포스포디에스테르 및 포스포로티오에이트 연결기이다. 갭머용 인터뉴클레오사이드 연결기 모티프는 (5'부터 3'까지) 하기이고: soooossssssssssooss; 여기서 'o'는 포스포디에스테르 인터뉴클레오사이드 연결기를 나타내고 's'는 포스포로티오에이트 인터뉴클레오사이드 연결기를 나타낸다. "개시 부위"는 갭머가 인간 핵산 서열에서 상보성인 5'-최말단 뉴클레오사이드를 나타낸다. "중단 부위"는 갭머가 인간 핵산 서열에서 상보성인 3'-최말단 뉴클레오사이드를 나타낸다.
표 3-9에서 열거된 각 변형된 올리고뉴클레오타이드는, 명시된 바와 같이, 인간 LRRK2 핵산 서열 서열번호: 1 또는 서열번호: 2에 상보성이다. 'N/A'는 변형된 올리고뉴클레오타이드가 100% 상보성을 가진 그 특정 핵산 서열에 상보성이지 않다는 것을 나타낸다. 아래 나타난 바와 같이, 인간 LRRK2 RNA의 서열에 상보성인 변형된 올리고뉴클레오타이드는 인간 LRRK2 RNA의 양을 감소시켰다.
실시예
4: 인간
LRRK2
RNA 발현
시험관내
, 단일 용량에서 혼합된
인터뉴클레오사이드
연결기가
있는 5-10-5
MOE
갭머의
효과
인간 LRRK2 핵산에 상보성인 변형된 올리고뉴클레오타이드는 시험관내 LRRK2 RNA에서 그것의 효과에 대하여 설계 및 시험되었다. 변형된 올리고뉴클레오타이드는 유사한 배양 조건을 가졌던 일련의 실험에서 시험되었다.
20,000 세포/웰의 밀도에서 배양된 SH-SY5Y 세포는 미처리된 대조군에 대하여 4,000 nM 농도의 변형된 올리고뉴클레오타이드로 또는 변형된 올리고뉴클레오타이드 없이 전기천공을 사용하여 형질감염되었다. 대략 24 시간 후, RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 실시예 2에서 기재된 바와 같이 인간 프라이머 프로브 세트 RTS3132를 사용하여 정량적 실시간 PCR에 의해 측정되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 별표 (*)로 표시된 퍼센트 대조군 값을 가진 변형된 올리고뉴클레오타이드는 프라이머 프로브 세트의 앰플리콘 영역을 표적화한다. 추가의 검정은 앰플리콘 영역을 표적화하는 올리고뉴클레오타이드의 효력 및 효능을 측정하는데 사용될 수 있다.
표 10-50에서 변형된 올리고뉴클레오타이드는 5-10-5 MOE 갭머이다. 갭머는 20개의 핵염기 길이이고, 여기서 중심 갭 단편은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 5개의 2'-MOE 뉴클레오사이드를 포함하는 5' 말단 및 3' 말단 둘 모두에서 윙 단편에 의해 측접된다. 갭머용 당 모티프는 (5'부터 3'까지) 하기이고: eeeeeddddddddddeeeee; 여기서 'd'는 2'-데옥시리보오스 당을 나타내고 'e'는 2-MOE 변형된 당을 나타낸다. 각 갭머 전반에 걸쳐 모든 시토신 잔기는 5-메틸 시토신이다. 각 갭머용 인터뉴클레오사이드 연결기는 혼합된 포스포디에스테르 및 포스포로티오에이트 연결기이다. 갭머용 인터뉴클레오사이드 연결기 모티프는 (5'부터 3'까지) 하기이고: soooossssssssssooss; 여기서 'o'는 포스포디에스테르 인터뉴클레오사이드 연결기를 나타내고 's'는 포스포로티오에이트 인터뉴클레오사이드 연결기를 나타낸다. "개시 부위"는 갭머가 인간 핵산 서열에서 상보성인 5'-최말단 뉴클레오사이드를 나타낸다. "중단 부위"는 갭머가 인간 핵산 서열에서 상보성인 3'-최말단 뉴클레오사이드를 나타낸다.
표 10-50에서 열거된 각 변형된 올리고뉴클레오타이드는, 명시된 바와 같이, 인간 LRRK2 핵산 서열 서열번호: 1 또는 서열번호: 2에 상보성이다. 'N/A'는 변형된 올리고뉴클레오타이드가 100% 상보성을 가진 그 특정 핵산 서열에 상보성이지 않다는 것을 나타낸다. 아래 나타난 바와 같이, 인간 LRRK2 RNA의 서열에 상보성인 변형된 올리고뉴클레오타이드는 인간 LRRK2 RNA의 양을 감소시켰다.
실시예 5: 인간 LRRK2 RNA 발현
시험관내
, 다중 용량에서 포스포로티오에이트 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
상기 실시예 1로부터 선택된 변형된 올리고뉴클레오타이드는 SH-SY5Y 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 1.125 μM, 2.250 μM, 4.500 μM, 9.000 μM, 및 18.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 1에서 본 명세서에 기재된) 인간 LRRK2 프라이머 프로브 세트 RTS3133_MGB는 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예 6: 인간 LRRK2 RNA 발현
시험관내
, 다중 용량에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
상기 실시예 2 및 3으로부터 선택된 변형된 올리고뉴클레오타이드는 SH-SY5Y 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 0.333 μM, 1.000 μM, 3.000 μM, 및 9.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 2에서 상기 기재된) 인간 LRRK2 프라이머 프로브 세트 RTS3132는 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예 7: 인간 LRRK2 RNA 발현
시험관내
, 다중 용량에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
상기 실시예 4로부터 선택된 변형된 올리고뉴클레오타이드는 SH-SY5Y 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 0.296, 0.888, 2.666, 및 8.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 2에서 본 명세서에 기재된) 인간 LRRK2 프라이머 프로브 세트 RTS3132는 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예 8: 인간 LRRK2 RNA 발현
시험관내
, 다중 용량에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
상기 실시예 4로부터 선택된 변형된 올리고뉴클레오타이드는 SH-SY5Y 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 0.444, 1.333, 4.000, 및 12.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 2에서 본 명세서에 기재된) 인간 LRRK2 프라이머 프로브 세트 RTS3132는 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예 9: 인간 LRRK2 RNA에 상보성인 혼합된 인터뉴클레오사이드 연결기가 있는 갭머의 설계
인간 LRRK2 핵산에 상보성인 변형된 올리고뉴클레오타이드는 설계되었다. 표 71에서 변형된 올리고뉴클레오타이드는 갭머이다. 갭머는 2'-데옥시뉴클레오사이드를 포함하는 그리고 및 cEt 뉴클레오사이드 및/또는 2'-MOE 뉴클레오사이드를 포함하는 5' 말단 및 3' 말단 둘 모두에서 윙 단편에 의해 측접되는 중심 갭 단편을 가지고 있다. 각 갭머 전반에 걸쳐 모든 시토신 잔기는 5'-메틸 시토신이다. 인터뉴클레오사이드 연결기는 혼합된 포스포디에스테르 인터뉴클레오사이드 연결기 및 포스포로티오에이트 인터뉴클레오사이드 연결기이다. 서열 및 화학 표기법 칼럼은, 5'-메틸 시토신, 당 화학, 및 인터뉴클레오사이드 연결기 화학을 포함하는, 서열을 특정하고, 여기서 첨자 'd'는 2'-데옥시리보오스 당을 나타내고; 첨자 'e'는 2'-MOE 변형된 당을 나타내고; 첨자 'k'는 cEt 변형된 당을 나타내고; 첨자 'o'는 포스포디에스테르 인터뉴클레오사이드 연결기를 나타내고; 첨자 's'는 포스포로티오에이트 인터뉴클레오사이드 연결기를 나타내고; 시토신 잔기 앞에 'm' 첨자는 5-메틸 시토신을 나타낸다. "개시 부위"는 갭머가 인간 핵산 서열에서 상보성인 5'-최말단 뉴클레오사이드를 나타낸다. "중단 부위"는 갭머가 인간 핵산 서열에서 상보성인 3'-최말단 뉴클레오사이드를 나타낸다.
아래 표에서 열거된 각 변형된 올리고뉴클레오타이드는, 명시된 바와 같이, 인간 LRRK2 핵산 서열 서열번호: 1 또는 서열번호: 2에 상보성이다. 'N/A'는 변형된 올리고뉴클레오타이드가 100% 상보성을 가진 그 특정 핵산 서열에 상보성이지 않다는 것을 나타낸다.
실시예 10: 자유 흡수를 통한
시험관내
인간 LRRK2 RNA 발현에서 혼합된 인터뉴클레오사이드 연결기가 있는 5-10-5 MOE 갭머의 효과
상기 실시예로부터 선택된 변형된 올리고뉴클레오타이드는 자유 흡수에 의해 A431 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 0.039, 0.156, 0.625, 2.500 및 10.000 μM 농도의 변형된 올리고뉴클레오타이드로 10,000 세포/웰의 밀도에서 플레이팅되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 2에서 본 명세서에 기재된) 인간 LRRK2 프라이머 프로브 세트 RTS3132는 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN®에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예
11:
붉은털 원숭이
LRRK2
RNA
시험관내
, 다중 용량에서 변형된
올리고뉴클레오타이드의
효과
붉은털 원숭이 LRRK2에 또한 상보성인, 상기 실시예로부터 선택된 변형된 올리고뉴클레오타이드는 LLC-MK2 원숭이 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 0.011, 0.034, 0.103, 0.309, 0.926, 2.778, 8.333, 및 25.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 공지된 표적 및 서열 CCTATAGGACTATCCAGGAA (서열번호: 3848)이 없는 혼합된 포스포디에스테르 및 포스포로티오에이트 백본이 있는 5-10-5 MOE 갭머인, 대조군 올리고뉴클레오타이드, 676630은 또한 시험되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. 인간 LRRK2 프라이머 프로브 세트 hLRRK2 LTS35700 (정방향 서열 CCAGGTACAATGCAAAGCTTAAT, 서열번호: 20으로서 본 명세서에 지정됨; 역방향 서열 TCAGTCCAATCACTGACAAGTT, 서열번호: 21로서 본 명세서에 지정됨; 프로브 서열 TTGGGAAGTCCTTGGTGTTCACCA, 서열번호: 22로서 본 명세서에 지정됨)은 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예
12: 인간
LRRK2
RNA 발현
시험관내
, 다중 용량에서 변형된
올리고뉴클레오타이드의
효과
상기 기재된 변형된 올리고뉴클레오타이드는 SH-SY5Y 세포내 다양한 용량에서 시험되었다. 세포는, 아래 표에서 특정된 바와 같이, 20,000 세포/웰의 밀도로 플레이팅되었고 0.011, 0.034, 0.103, 0.309, 0.926, 2.778, 8.333, 및 25.000 μM 농도의 변형된 올리고뉴클레오타이드로 전기천공을 사용하여 형질감염되었다. 공지된 표적이 없는 혼합된 포스포디에스테르 및 포스포로티오에이트 백본이 있는 5-10-5 MOE 갭머인, 대조군 올리고뉴클레오타이드, 676630은 또한 시험되었다. 대략 24 시간의 처리 기간 후, 총 RNA는 세포로부터 단리되었고 LRRK2 RNA 수준은 정량적 실시간 PCR에 의해 측정되었다. (실시예 11에서 본 명세서에 기재된) 인간 LRRK2 프라이머 프로브 세트 LTS35700은 RNA 수준을 측정하는데 사용되었다. LRRK2 RNA 수준은, RIBOGREEN에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다 결과는 미처리된 대조군 세포에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다. 아래 표에서 설명된 바와 같이, LRRK2 RNA 수준은 변형된 올리고뉴클레오타이드-처리된 세포에서 용량-의존적 방식으로 감소되었다. IC50은 Prism6 소프트웨어를 사용하는 "log(억제제) 대 반응 - 가변 경사 (4 파라미터)" 식을 사용하여 계산되었다.
실시예 13: 형질전환 마우스에서 인간 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 활성, 2주 평가
상기 기재된 변형된 올리고뉴클레오타이드는 2주 후 활성을 평가하기 위해 인간 BAC 야생형 LRRK2 형질전환 마우스 모델 B6;SJL-Tg(LRRK2)66Mjff/J; Stock No: 013725, The Jackson Laboratory)에서 시험되었다. BAC LRRK2-Wt 이식유전자에 대하여 반접합성인 마우스는 생존성 및 가임성이다. 이들 마우스는 BAC 이식유전자 상에서 인간 LRRK2 프로모터/인핸서 영역에 의해 유도된 야생형 인간 류신-풍부 반복 키나제 2 (LRRK2) 유전자를 발현시킨다 (Ouyang Y 등, 2011). 이 모델로부터 마우스는, 척수 및 뇌를 포함하는, 다양한 조직에서 인간 LRRK2를 발현시킨다.
처리
LRRK2 형질전환 마우스 각각은 아래 표에서 열거된 300μg의 변형된 올리고뉴클레오타이드의 단일 뇌혈관내 (ICV) 용량을 받았다. 각 처리 그룹은 4마리 마우스로 이루어졌다. 4마리 마우스의 그룹은 음성 대조군으로서 PBS를 받았다.
RNA 분석
2주 후, 마우스는 희생되었고, RNA는 (실시예 11에서 상기 본 명세서에 기재된) 프라이머 프로브 세트 hLRRK2 LTS35700을 사용하여 LRRK2의 RNA 발현의 측정의 실시간 PCR 분석을 위하여 피질 뇌 조직 및 척수로부터 추출되었다. 결과는, 사이클로필린 A로 정규화된, PBS 대조군에 비하여 에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다.
아래 표에서 나타난 바와 같이, 변형된 올리고뉴클레오타이드에 의한 처리는 PBS 대조군에 비교하여 인간 LRRK2 RNA의 감소를 초래하였다.
실시예 14: 형질전환 마우스에서 인간 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 활성, 8주 평가
상기 기재된 변형된 올리고뉴클레오타이드는 8주 후 활성을 평가하기 위해 인간 BAC 야생형 LRRK2 형질전환 마우스 모델에서 시험되었다. BAC LRRK2-Wt 이식유전자에 대하여 반접합성인 마우스는 생존성 및 가임성이다. 이들 마우스는 BAC 이식유전자 상에서 인간 LRRK2 프로모터/인핸서 영역에 의해 유도된 야생형 인간 류신-풍부 반복 키나제 2 (LRRK2) 유전자를 발현시킨다 (Ouyang Y 등, 2011). 이 모델로부터 마우스는, 척수 및 뇌를 포함하는, 다양한 조직에서 인간 LRRK2를 발현시킨다.
처리
LRRK2 형질전환 마우스 각각은 아래 표에서 열거된 300μg의 변형된 올리고뉴클레오타이드의 단일 ICV 용량을 받았다. 각 처리 그룹은 4마리 마우스로 이루어졌다. 4마리 마우스의 그룹은 음성 대조군으로서 PBS를 받았다.
RNA 분석
8주 후, 마우스는 희생되었고, RNA는 (실시예 11에서 상기 본 명세서에 기재된) 프라이머 프로브 세트 hLRRK2 LTS35700을 사용하여 LRRK2의 RNA 발현의 측정의 실시간 PCR 분석을 위하여 피질 뇌 조직 및 척수로부터 추출되었다. 결과는, 사이클로필린 A로 정규화된, PBS 대조군에 비하여 에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다.
아래 표에서 나타난 바와 같이, 변형된 올리고뉴클레오타이드에 의한 처리는 PBS 대조군에 비교하여 인간 LRRK2 RNA의 감소를 초래하였다.
실시예 15: 형질전환 랫트에서 인간 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 활성
상기 기재된 변형된 올리고뉴클레오타이드는 활성을 평가하기 위해 인간 BAC G2019S 돌연변이체 LRRK2 형질전환 랫트 (NTac:SD-Tg(LRRK*G2019S)571Cjli; Taconic) 모델에서 시험되었다. 모델은 NTac:SD 접합체속에 G2019S를 가진 전체 인간 LRRK2 유전자의 전핵 주사를 통해 창작되었다. 이 모델로부터 랫트는, 척수 및 뇌를 포함하는 다양한 조직에서 인간 LRRK2를 발현시킨다 (West AB 등, J. Comp. Neurology, 2014, 522(11):2465-2480).
처리
LRRK2 형질전환 랫트 각각은 아래 표에서 열거된 1,000μg의 변형된 올리고뉴클레오타이드의 단일 ICV 용량을 받았다. 각 처리 그룹은 4-5마리 랫트로 이루어졌다. 4마리 랫트의 그룹은 음성 대조군으로서 PBS를 받았다.
RNA 분석
2주 후, 랫트는 희생되었고, RNA는 (실시예 11에서 상기 본 명세서에 기재된) 프라이머 프로브 세트 hLRRK2 LTS35700을 사용하여 LRRK2의 RNA 발현의 측정의 실시간 PCR 분석을 위하여 뇌간, 피질 뇌 조직, 척수, 폐 및 신장으로부터 추출되었다. 결과는, 사이클로필린 A로 정규화된, PBS 대조군에 비하여 에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다.
아래 표에서 나타난 바와 같이, 변형된 올리고뉴클레오타이드에 의한 처리는 PBS 대조군에 비교하여 인간 LRRK2 RNA의 감소를 초래하였다.
실시예 16: 형질전환 랫트에서 인간 LRRK2에 상보성인 변형된 인터뉴클레오사이드의 효력
상기 기재된 변형된 올리고뉴클레오타이드는, 올리고뉴클레오타이드의 효력을 시험하기 위해, 상기 본 명세서에 기재된, 인간 BAC G2019S 돌연변이체 LRRK2 형질전환 랫트 (NTac:SD-Tg(LRRK*G2019S)571Cjli) 모델에서 시험되었다.
처리
LRRK2 형질전환 랫트 각각은 아래 표에서 열거된 10, 30, 100, 300, 700, 1,000, 또는 3,000 μg의 변형된 올리고뉴클레오타이드의 단일 뇌혈관내 (ICV) 용량을 받았다. 각 처리 그룹은 5마리 랫트로 이루어졌다. 5마리 랫트의 그룹은 각 투약 그룹에 대하여 음성 대조군으로서 PBS를 받았다.
RNA 분석
2주 후, 랫트는 희생되었고 RNA는 (실시예 11에서 상기 본 명세서에 기재된) 프라이머 프로브 세트 hLRRK2 LTS35700을 사용하여 LRRK2의 RNA 발현의 측정의 실시간 PCR 분석을 위하여 대뇌피질로부터 추출되었다. 결과는, 사이클로필린 A로 정규화된, PBS 대조군에 비하여 에 비하여 퍼센트 LRRK2 RNA 수준으로서 아래 표에서 제시된다.
아래 표에서 나타난 바와 같이, 변형된 올리고뉴클레오타이드에 의한 처리는 PBS 대조군에 비교하여 인간 LRRK2 RNA의 감소를 초래하였다. 용량 반응 데이터는 GraphPad Prism 6 소프트웨어 (San Diego, CA)를 사용하여 분석되었다. ED50 값은, 하기 제약조건: ED50에 대하여 최하부 > 0, 최상부 = 100, F = 50이 있는, GraphPad 식 "log(아고니스트) 대 반응 -- Find ECanything"에서 만들어진 것을 이용하여 log 전환된 용량 또는 농도 그리고 개별 동물 LRRK2 RNA 수준으로부터 계산되었다.
실시예 17: 야생형 마우스에서 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 내성, 3 시간 FOB 평가
상기 기재된 변형된 올리고뉴클레타이드는 올리고뉴클레오타이드의 내성을 평가하기 위해 야생형 암컷 C57/B16 마우스에서 시험되었다. 야생형 암컷 C57/B16 마우스 각각은 아래 표에서 열거된 700 μg의 변형된 올리고뉴클레오타이드의 단일 ICV 용량을 받았다. 각 처리 그룹은 4마리 마우스로 이루어졌다. 4마리 마우스의 그룹은 (아래 별도 표에서 확인된) 각 실험용 음성 대조군으로서 PBS를 받았다. 3 시간 후기-주사에서, 마우스는 7개의 상이한 기준에 따라 평가되었다. 기준은 (1) 마우스가 활발하고, 민첩하고 반응성이었음; (2) 마우스가 자극 없이 서있거나 움츠렸음; (3) 마우스가 자극 없이 어떤 움직임을 보여주었음; (4) 마우스가 들어올린 후 전방 움직임을 나타냈음; (5) 마우스가 들어올린 후 어떤 움직임을 보여주었음; (6) 마우스가 꼬리 핀칭에 반응하였음; (7) 정상 호흡이다. 7개의 기준 각각에 대하여, 마우스는 기준을 충족시켰다면 0 그리고 그렇지 않았다면 1의 서브스코어 (기능적 관찰 배터리 스코어 또는 FOB)가 제공되었다. 모두 7개의 기준이 평가된 후, 스코어는 각 마우스에 대하여 합계되었고 각 처리 그룹 내에서 평균되었다. 결과는 아래 표에서 제시된다.
실시예 18: 랫트에서 인간 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 내성, 3시간 FOB 평가
상기 기재된 변형된 올리고뉴클레오타이드는 올리고뉴클레오타이드의 내성을 평가하기 위해 스프라그 돌리 랫트에서 시험되었다. 스프라그 돌리 랫트 각각은 아래 표에서 열거된 3 mg의 올리고뉴클레오타이드의 단일 척수내 (IT) 용량을 받았다. 각 처리 그룹은 3-4마리 랫트로 이루어졌다. 4마리 랫트의 그룹은 (아래 별도 표에서 확인된) 각 실험용 음성 대조군으로서 PBS를 받았다. 3 시간 후기-주사에서, 바디의 7개 상이한 부위의 움직임은 각 랫트에 대하여 평가되었다. 7개의 바디 부위는 (1) 랫트의 꼬리; (2) 랫트의 뒷태; (3) 랫트의 뒷다리; (4) 랫트의 뒷발; (5) 랫트의 앞발; (6) 랫트의 앞태; (7) 랫트의 두부이다. 7개의 상이한 바디 부위의 각각에 대하여, 각 랫트는 바디 부위가 움직이고 있었다면 0 그리고 바디 부위가 움직이지 않았다면 1의 서브-스코어가 제공되었다. 7개 기준의 각각에 대하여, 렛트는 상기 기준을 충족시키면 0 또는 바디 부위가 그렇지 않으면 1의 서브스코어 (기능적 관찰 배터리 스코어 또는 FOB)가 제공되었다. 모두 7개의 기준이 평가된 후, 스코어는 각 랫트에 대하여 합계되었고 각 처리 그룹 내에서 평균되었다. 결과는 아래 표에서 제시된다.
실시예 19: PFF 모델에서 변형된 올리고뉴클레오타이드에 의한 LRRK2의 예방적 감소
야생형 마우스는 PBS 비히클 단독 또는 아래 표에서 열거된 700 μg의 올리고뉴클레오타이드의 단일 ICV 주사를 받았다. 각 처리 그룹은 11 또는 12마리 마우스로 이루어졌다. 올리고뉴클레오타이드 처리 2주 후, α-시누클레인의 사전형성된 피브릴 (PFFs)는, 기재된 바와 같이, 몇몇 뇌 영역에서 α-시누클레인 응집체의 형성 및 운동 장해를 초래하는, 선조체속에 주사되었다 (참고 Luk 등, Science, 2012, 338, 949-953). 하나의 대조군 그룹은 PFFs의 주사를 받지 않았다. 올리고뉴클레오타이드 처리 55일 후, 운동 기능은 와이어 행 시험에서 시험되었다. 결과는 각 처리 그룹의 마우스가 와이어상에 남아있었던 시간의 평균 기간으로서 아래 표에서 제시된다.
와이어 행 시험 1일 후, 각 처리 그룹에서 모든 마우스는 올리고뉴클레오타이드 및 PFF 주사를 받지 않았던 그룹을 제외하고 희생되었고; 그 그룹에서 단지 4마리 마우스는 희생되었다. 동물은 빙냉된 PBS로 관류되었다. 동측성 반구는 고정되었고 면역화학을 위하여 가공되었다. 대측성 중뇌 및 선조체는 RNA 분석때까지 절개 및 동결되었고, 반면 전체 대측성 대뇌피질은 단백질 분석때까지 절개 및 동결되었다. LRRK2 RNA 발현은 쥣과 프라이머 프로브 세트 RTS3043 (정향방 서열 GGCGAGTTATCCGCACCAT, 서열번호: 23으로서 본 명세서에 지정됨; 역방향 서열 CCAAAACCAGCATGACATTCTTAA, 서열번호:24로서 본 명세서에 지정됨; 프로브 서열 TGAGAGCCATGGCCACAGCACAA, 서열번호: 25로서 본 명세서에 지정됨)을 사용하여 정량적 실시간 PCR에 의해 분석되었다. LRRK2 RNA 수준은, RIBOGREEN에 의해 측정된 바와 같이, 총 RNA 함량에 따라 조정되었다. 결과는 올리고뉴클레오타이드 처리도 PFF 주사도 받지 않았던 야생형 대조군 그룹에 비하여 평균 퍼센트 억제로서 아래 표에서 나타난다.
대뇌피질에서 LRRK2, α-시누클레인, 및 과인산화된 α-시누클레인 (p-α-syn) 단백질 수준은 웨스턴 블랏에 의해 분석되었다. 대측성 대뇌피질 조직은 RIPA 완충액에서 먼저 균질화되었고 13,300x g에서 원심분리되었다. 상청액은 LRRK2 단백질 수준에 대하여 웨스턴 블랏 처리되었고, β-튜불린은 장입 대조군으로서 사용되었다. 결과는 대뇌피질에서 LRRK2 단백질 수준이 올리고뉴클레오타이드 처리를 받지 않았던 동물에서보다 올리고뉴클레오타이드 처리된 동물에서 상당히 더 낮았음을 나타냈다. 펠렛은 RIPA 완충액에서 재현탁되었고, 100,000x g에서 원심분리되었고, 생성된 불용성 물질은 2% SDS 완충액에서 추가로 현탁되었고, 이어서 추가로 100,000x g 회전되었다. 생성된 상청액은 α-시누클레인 및 p-α-syn에 대하여 웨스턴 블랏에 의해 분석되었다. 결과는 PFF 주사가, Luk 등에서 보고된 바와 같이, 불용성 응집체속에 내인성 마우스 α-시누클레인의 동원을 초래하였음을 보여주었다. 응집체는 또한 과인산화되었다. 올리고뉴클레오타이드 처리는, 웨스턴 블랏에서 불용성 마우스 α-시누클레인 및 p-α-syn의 감소에 의해 증명된 바와 같이, 응집체의 형성을 감소시켰다. 흑질에서 p-α-syn 응집체는 면역조직화학에 의해 가시화되었다. 각 처리 그룹으로부터 각 크기의 샘플에 대하여 관찰된 응집체의 평균 수는 아래 표에서 나타난다. 결과의 1원 ANOVA 시험은 PBS 처리된 동물과 올리고뉴클레오타이드 처리된 동물 사이 차이가 유의미하였음을 보여주었다.
실시예 20: PFF 모델에서 변형된 올리고뉴클레오타이드에 의한 LRRK2의 감소
PFFs의 주사후 야생형 마우스에서 올리고뉴클레오타이드 감소의 효과는 690093을 사용하여 평가되었다. 마우스는 올리고뉴클레오타이드 처리가 PFF 주사 2주 전 대신에 PFF 주사 2주 후 발생하였음을 제외하고 실시예 19에서 기재된 바와 같이 처리되었다. 각 처리 그룹은 10마리 동물로 이루어졌다. PFF 주사 55일 후, 마우스는, 실시예 19에서 기재된 바와 같이, 와이어 행 시험에서 평가되었다. 와이어 행 시험 1일 후, 마우스는 희생되었고, 중뇌, 선조체, 및 흑질은 수집되었고, 실시예 19에서 기재된 바와 같이, LRRK2 RNA 및 p-α-syn 응집체는 측정되었다. 결과는 각 처리 그룹에 대한 평균으로서 아래 표에서 나타난다. "nd"의 기재는 데이터가 그 처리 그룹에 대하여 수집되지 않았음을 나타낸다. 결과는 변형된 올리고뉴클레오타이드가 PFF 모델의 개시 후 투여된 경우 조차, 운동 기능이 개선되었고 병리적 응집체가 감소되었음을 보여준다.
실시예 21: 장기 연구에서 PFF 모델에서 변형된 올리고뉴클레오타이드에 의한 LRRK2의 예방적 감소
변형된 올리고뉴클레오타이드는 변형된 올리고뉴클레오타이드에 의한 장기 처리가 도파민작용성 뉴런을 보호하는지를 결정하기 위해 장기 연구에서 시험되었다. 흑질 치밀부에서 α-syn 응집체의 축적은 경시적으로 도파민작용성 뉴런의 생존을 손상시킨다 (Luk 2012, Tran 2014).
PFFs의 주사후 야생형 마우스에서 올리고뉴클레오타이드 감소의 효과는 공지된 표적이 없이 혼합된 포스포디에스테르 및 포스포로티오에이트 백본을 가진 5-10-5 MOE 갭머인, 대조군 올리고뉴클레오타이드 676630 또는 690093을 사용하여 평가되었다. 마우스는 90일에 690093의 제2 ICV 용량을 마우스가 받았던 것을 제외하고 실시예 19에서 기재된 바와 같이 처리되었고, 제1 ICV 처리 후 180일에 희생되었다. 각 처리 그룹은 12마리 동물로 이루어졌다. 희생에서, 중뇌, 선조체, 및 흑질은 수집되었고, LRRK2 RNA 및 p-α-syn 응집체는, 실시예 19에서 기재된 바와 같이, 측정되었고, 도파민작용성 세포는 항-티로신 수산화효소 (TH) 항체를 사용하여 면역조직화학에 의해 정량화되었다. 결과는 각 처리 그룹에 대하여 평균으로서 아래 표에서 나타난다. 결과는, LRRK2에 상보성인 변형된 올리고뉴클레오타이드로 처리된 그룹에서, 병리적 응집체의 수가 장기 처리 과정 동안 감소되었음을 보여준다. 추가적으로, TH-양성 뉴런의 정량화는 690093-매개된 LRRK2 억압이 대조군 처리된 세포에 비교된 경우 동측성 흑질 치밀부에서 TH-양성 세포를 구제하였음을 보여주었다.
실시예 22: 랫트에서 인간 LRRK2에 상보성인 변형된 올리고뉴클레오타이드의 내성, 장기 평가
동일 조건 하에서 실시된 별도 연구에서, 상기 기재된 변형된 올리고뉴클레오타이드는 올리고뉴클레오타이드의 장기 내성을 평가하기 위해 스프라그 돌리 랫트에서 시험되었다. 스프라그 돌리 랫트 각각은 3mg의 올리고뉴클레오타이드 또는 PBS의 단일 척수내 (IT) 전달된 용량을 받았다. 1주 후기-처리를 시작하는 6주 동안, 각 동물은 유해 효과에 대하여 훈련된 관찰자에 의해 매주 칭량되었고 평가되었다. 유해 효과는, 비제한적으로, 하기를 포함하는 PBS-처리된 대조군 동물에서 전형적이지 않은 신경학적 기능장애로서 정의되었다: 비정상 사지 벌어짐, 비정상 걸음걸이, 떨림, 비정상 호흡, 마비, 및 경직. 유해 효과의 개시는 기능장애가 먼저 기록된 경우 후기-투약하는 주로서 정의된다. 유해 효과가 달성되지 않았다면, 개시는 없다 (-). 유해 효과의 개시는 전형적으로 PBS-처리된 동물과 유사한 체중 증가/유지의 부족에 의해 정의된 바와 같이 번창하지 못함과 상관관계가 있다. 유사한 내성 평가는 하기에서 기재되었다: Ostergaard 등, Nucleic Acids Res. 2013 Nov; 41(21): 9634-9650 및 Southwell 등, Mol Ther. 2014 Dec; 22(12): 2093-2106. 아래 표에서 나타난 바와 같이, 876031, 780241, 802714, 803268, 876604, 및 934556은 장기 내성 평가에서 양호하게 용인되었다.
본 개시내용은 하기 비제한 번호로 매겨진 청구범위를 제공한다.
SEQUENCE LISTING
<110> Ionis Pharmaceuticals, Inc.
<120> COMPOUNDS AND METHODS FOR REDUCING LRRK2 EXPRESSION
<130> BIOL0324US.L
<150> 62/690,790
<151> 2018-06-27
<160> 3848
<170> KoPatentIn version 3.0
<210> 1
<211> 9239
<212> DNA
<213> Homo sapiens
<400> 1
gcgctggctg cgggcggtga gctgagctcg cccccgggga gctgtggccg gcgcccctgc 60
cggttccctg agcagcggac gttcatgctg ggagggcggc gggttggaag caggtgccac 120
catggctagt ggcagctgtc aggggtgcga agaggacgag gaaactctga agaagttgat 180
agtcaggctg aacaatgtcc aggaaggaaa acagatagaa acgctggtcc aaatcctgga 240
ggatctgctg gtgttcacgt actccgagca cgcctccaag ttatttcaag gcaaaaatat 300
ccatgtgcct ctgttgatcg tcttggactc ctatatgaga gtcgcgagtg tgcagcaggt 360
gggttggtca cttctgtgca aattaataga agtctgtcca ggtacaatgc aaagcttaat 420
gggaccccag gatgttggaa atgattggga agtccttggt gttcaccaat tgattcttaa 480
aatgctaaca gttcataatg ccagtgtaaa cttgtcagtg attggactga agaccttaga 540
tctcctccta acttcaggta aaatcacctt gctgatattg gatgaagaaa gtgatatttt 600
catgttaatt tttgatgcca tgcactcatt tccagccaat gatgaagtcc agaaacttgg 660
atgcaaagct ttacatgtgc tgtttgagag agtctcagag gagcaactga ctgaatttgt 720
tgagaacaaa gattatatga tattgttaag tgcgttaaca aattttaaag atgaagagga 780
aattgtgctt catgtgctgc attgtttaca ttccctagcg attccttgca ataatgtgga 840
agtcctcatg agtggcaatg tcaggtgtta taatattgtg gtggaagcta tgaaagcatt 900
ccctatgagt gaaagaattc aagaagtgag ttgctgtttg ctccataggc ttacattagg 960
taattttttc aatatcctgg tattaaacga agtccatgag tttgtggtga aagctgtgca 1020
gcagtaccca gagaatgcag cattgcagat ctcagcgctc agctgtttgg ccctcctcac 1080
tgagactatt ttcttaaatc aagatttaga ggaaaagaat gagaatcaag agaatgatga 1140
tgagggggaa gaagataaat tgttttggct ggaagcctgt tacaaagcat taacgtggca 1200
tagaaagaac aagcacgtgc aggaggccgc atgctgggca ctaaataatc tccttatgta 1260
ccaaaacagt ttacatgaga agattggaga tgaagatggc catttcccag ctcataggga 1320
agtgatgctc tccatgctga tgcattcttc atcaaaggaa gttttccagg catctgcgaa 1380
tgcattgtca actctcttag aacaaaatgt taatttcaga aaaatactgt tatcaaaagg 1440
aatacacctg aatgttttgg agttaatgca gaagcatata cattctcctg aagtggctga 1500
aagtggctgt aaaatgctaa atcatctttt tgaaggaagc aacacttccc tggatataat 1560
ggcagcagtg gtccccaaaa tactaacagt tatgaaacgt catgagacat cattaccagt 1620
gcagctggag gcgcttcgag ctattttaca ttttatagtg cctggcatgc cagaagaatc 1680
cagggaggat acagaatttc atcataagct aaatatggtt aaaaaacagt gtttcaagaa 1740
tgatattcac aaactggtcc tagcagcttt gaacaggttc attggaaatc ctgggattca 1800
gaaatgtgga ttaaaagtaa tttcttctat tgtacatttt cctgatgcat tagagatgtt 1860
atccctggaa ggtgctatgg attcagtgct tcacacactg cagatgtatc cagatgacca 1920
agaaattcag tgtctgggtt taagtcttat aggatacttg attacaaaga agaatgtgtt 1980
cataggaact ggacatctgc tggcaaaaat tctggtttcc agcttatacc gatttaagga 2040
tgttgctgaa atacagacta aaggatttca gacaatctta gcaatcctca aattgtcagc 2100
atctttttct aagctgctgg tgcatcattc atttgactta gtaatattcc atcaaatgtc 2160
ttccaatatc atggaacaaa aggatcaaca gtttctaaac ctctgttgca agtgttttgc 2220
aaaagtagct atggatgatt acttaaaaaa tgtgatgcta gagagagcgt gtgatcagaa 2280
taacagcatc atggttgaat gcttgcttct attgggagca gatgccaatc aagcaaagga 2340
gggatcttct ttaatttgtc aggtatgtga gaaagagagc agtcccaaat tggtggaact 2400
cttactgaat agtggatctc gtgaacaaga tgtacgaaaa gcgttgacga taagcattgg 2460
gaaaggtgac agccagatca tcagcttgct cttaaggagg ctggccctgg atgtggccaa 2520
caatagcatt tgccttggag gattttgtat aggaaaagtt gaaccttctt ggcttggtcc 2580
tttatttcca gataagactt ctaatttaag gaaacaaaca aatatagcat ctacactagc 2640
aagaatggtg atcagatatc agatgaaaag tgctgtggaa gaaggaacag cctcaggcag 2700
cgatggaaat ttttctgaag atgtgctgtc taaatttgat gaatggacct ttattcctga 2760
ctcttctatg gacagtgtgt ttgctcaaag tgatgacctg gatagtgaag gaagtgaagg 2820
ctcatttctt gtgaaaaaga aatctaattc aattagtgta ggagaatttt accgagatgc 2880
cgtattacag cgttgctcac caaatttgca aagacattcc aattccttgg ggcccatttt 2940
tgatcatgaa gatttactga agcgaaaaag aaaaatatta tcttcagatg attcactcag 3000
gtcatcaaaa cttcaatccc atatgaggca ttcagacagc atttcttctc tggcttctga 3060
gagagaatat attacatcac tagacctttc agcaaatgaa ctaagagata ttgatgccct 3120
aagccagaaa tgctgtataa gtgttcattt ggagcatctt gaaaagctgg agcttcacca 3180
gaatgcactc acgagctttc cacaacagct atgtgaaact ctgaagagtt tgacacattt 3240
ggacttgcac agtaataaat ttacatcatt tccttcttat ttgttgaaaa tgagttgtat 3300
tgctaatctt gatgtctctc gaaatgacat tggaccctca gtggttttag atcctacagt 3360
gaaatgtcca actctgaaac agtttaacct gtcatataac cagctgtctt ttgtacctga 3420
gaacctcact gatgtggtag agaaactgga gcagctcatt ttagaaggaa ataaaatatc 3480
agggatatgc tcccccttga gactgaagga actgaagatt ttaaacctta gtaagaacca 3540
catttcatcc ctatcagaga actttcttga ggcttgtcct aaagtggaga gtttcagtgc 3600
cagaatgaat tttcttgctg ctatgccttt cttgcctcct tctatgacaa tcctaaaatt 3660
atctcagaac aaattttcct gtattccaga agcaatttta aatcttccac acttgcggtc 3720
tttagatatg agcagcaatg atattcagta cctaccaggt cccgcacact ggaaatcttt 3780
gaacttaagg gaactcttat ttagccataa tcagatcagc atcttggact tgagtgaaaa 3840
agcatattta tggtctagag tagagaaact gcatctttct cacaataaac tgaaagagat 3900
tcctcctgag attggctgtc ttgaaaatct gacatctctg gatgtcagtt acaacttgga 3960
actaagatcc tttcccaatg aaatggggaa attaagcaaa atatgggatc ttcctttgga 4020
tgaactgcat cttaactttg attttaaaca tataggatgt aaagccaaag acatcataag 4080
gtttcttcaa cagcgattaa aaaaggctgt gccttataac cgaatgaaac ttatgattgt 4140
gggaaatact gggagtggta aaaccacctt attgcagcaa ttaatgaaaa ccaagaaatc 4200
agatcttgga atgcaaagtg ccacagttgg catagatgtg aaagactggc ctatccaaat 4260
aagagacaaa agaaagagag atctcgtcct aaatgtgtgg gattttgcag gtcgtgagga 4320
attctatagt actcatcccc attttatgac gcagcgagca ttgtaccttg ctgtctatga 4380
cctcagcaag ggacaggctg aagttgatgc catgaagcct tggctcttca atataaaggc 4440
tcgcgcttct tcttcccctg tgattctcgt tggcacacat ttggatgttt ctgatgagaa 4500
gcaacgcaaa gcctgcatga gtaaaatcac caaggaactc ctgaataagc gagggttccc 4560
tgccatacga gattaccact ttgtgaatgc caccgaggaa tctgatgctt tggcaaaact 4620
tcggaaaacc atcataaacg agagccttaa tttcaagatc cgagatcagc ttgttgttgg 4680
acagctgatt ccagactgct atgtagaact tgaaaaaatc attttatcgg agcgtaaaaa 4740
tgtgccaatt gaatttcccg taattgaccg gaaacgatta ttacaactag tgagagaaaa 4800
tcagctgcag ttagatgaaa atgagcttcc tcacgcagtt cactttctaa atgaatcagg 4860
agtccttctt cattttcaag acccagcact gcagttaagt gacttgtact ttgtggaacc 4920
caagtggctt tgtaaaatca tggcacagat tttgacagtg aaagtggaag gttgtccaaa 4980
acaccctaag ggcattattt cgcgtagaga tgtggaaaaa tttctttcaa aaaaaaggaa 5040
atttccaaag aactacatgt cacagtattt taagctccta gaaaaattcc agattgcttt 5100
gccaatagga gaagaatatt tgctggttcc aagcagtttg tctgaccaca ggcctgtgat 5160
agagcttccc cattgtgaga actctgaaat tatcatccga ctatatgaaa tgccttattt 5220
tccaatggga ttttggtcaa gattaatcaa tcgattactt gagatttcac cttacatgct 5280
ttcagggaga gaacgagcac ttcgcccaaa cagaatgtat tggcgacaag gcatttactt 5340
aaattggtct cctgaagctt attgtctggt aggatctgaa gtcttagaca atcatccaga 5400
gagtttctta aaaattacag ttccttcttg tagaaaaggc tgtattcttt tgggccaagt 5460
tgtggaccac attgattctc tcatggaaga atggtttcct gggttgctgg agattgatat 5520
ttgtggtgaa ggagaaactc tgttgaagaa atgggcatta tatagtttta atgatggtga 5580
agaacatcaa aaaatcttac ttgatgactt gatgaagaaa gcagaggaag gagatctctt 5640
agtaaatcca gatcaaccaa ggctcaccat tccaatatct cagattgccc ctgacttgat 5700
tttggctgac ctgcctagaa atattatgtt gaataatgat gagttggaat ttgaacaagc 5760
tccagagttt ctcctaggtg atggcagttt tggatcagtt taccgagcag cctatgaagg 5820
agaagaagtg gctgtgaaga tttttaataa acatacatca ctcaggctgt taagacaaga 5880
gcttgtggtg ctttgccacc tccaccaccc cagtttgata tctttgctgg cagctgggat 5940
tcgtccccgg atgttggtga tggagttagc ctccaagggt tccttggatc gcctgcttca 6000
gcaggacaaa gccagcctca ctagaaccct acagcacagg attgcactcc acgtagctga 6060
tggtttgaga tacctccact cagccatgat tatataccga gacctgaaac cccacaatgt 6120
gctgcttttc acactgtatc ccaatgctgc catcattgca aagattgctg actacggcat 6180
tgctcagtac tgctgtagaa tggggataaa aacatcagag ggcacaccag ggtttcgtgc 6240
acctgaagtt gccagaggaa atgtcattta taaccaacag gctgatgttt attcatttgg 6300
tttactactc tatgacattt tgacaactgg aggtagaata gtagagggtt tgaagtttcc 6360
aaatgagttt gatgaattag aaatacaagg aaaattacct gatccagtta aagaatatgg 6420
ttgtgcccca tggcctatgg ttgagaaatt aattaaacag tgtttgaaag aaaatcctca 6480
agaaaggcct acttctgccc aggtctttga cattttgaat tcagctgaat tagtctgtct 6540
gacgagacgc attttattac ctaaaaacgt aattgttgaa tgcatggttg ctacacatca 6600
caacagcagg aatgcaagca tttggctggg ctgtgggcac accgacagag gacagctctc 6660
atttcttgac ttaaatactg aaggatacac ttctgaggaa gttgctgata gtagaatatt 6720
gtgcttagcc ttggtgcatc ttcctgttga aaaggaaagc tggattgtgt ctgggacaca 6780
gtctggtact ctcctggtca tcaataccga agatgggaaa aagagacata ccctagaaaa 6840
gatgactgat tctgtcactt gtttgtattg caattccttt tccaagcaaa gcaaacaaaa 6900
aaattttctt ttggttggaa ccgctgatgg caagttagca atttttgaag ataagactgt 6960
taagcttaaa ggagctgctc ctttgaagat actaaatata ggaaatgtca gtactccatt 7020
gatgtgtttg agtgaatcca caaattcaac ggaaagaaat gtaatgtggg gaggatgtgg 7080
cacaaagatt ttctcctttt ctaatgattt caccattcag aaactcattg agacaagaac 7140
aagccaactg ttttcttatg cagctttcag tgattccaac atcataacag tggtggtaga 7200
cactgctctc tatattgcta agcaaaatag ccctgttgtg gaagtgtggg ataagaaaac 7260
tgaaaaactc tgtggactaa tagactgcgt gcacttttta agggaggtaa tggtaaaaga 7320
aaacaaggaa tcaaaacaca aaatgtctta ttctgggaga gtgaaaaccc tctgccttca 7380
gaagaacact gctctttgga taggaactgg aggaggccat attttactcc tggatctttc 7440
aactcgtcga cttatacgtg taatttacaa cttttgtaat tcggtcagag tcatgatgac 7500
agcacagcta ggaagcctta aaaatgtcat gctggtattg ggctacaacc ggaaaaatac 7560
tgaaggtaca caaaagcaga aagagataca atcttgcttg accgtttggg acatcaatct 7620
tccacatgaa gtgcaaaatt tagaaaaaca cattgaagtg agaaaagaat tagctgaaaa 7680
aatgagacga acatctgttg agtaagagag aaataggaat tgtctttgga taggaaaatt 7740
attctctcct cttgtaaata tttattttaa aaatgttcac atggaaaggg tactcacatt 7800
ttttgaaata gctcgtgtgt atgaaggaat gttattattt ttaatttaaa tatatgtaaa 7860
aatacttacc agtaaatgtg tattttaaag aactatttaa aacacaatgt tatatttctt 7920
ataaatacca gttactttcg ttcattaatt aatgaaaata aatctgtgaa gtacctaatt 7980
taagtactca tactaaaatt tataaggccg ataatttttt gttttcttgt ctgtaatgga 8040
ggtaaacttt attttaaatt ctgtgcttaa gacaggacta ttgcttgtcg atttttctag 8100
aaatctgcac ggtataatga aaatattaag acagtttccc atgtaatgta ttccttctta 8160
gattgcatcg aaatgcacta tcatatatgc ttgtaaatat tcaaatgaat ttgcactaat 8220
aaagtccttt gttggtatgt gaattctctt tgttgctgtt gcaaacagtg catcttacac 8280
aacttcactc aattcaaaag aaaactccat taaaagtact aatgaaaaaa catgacatac 8340
tgtcaaagtc ctcatatcta ggaaagacac agaaactctc tttgtcacag aaactctctg 8400
tgtctttcct agacataata gagttgtttt tcaactctat gtttgaatgt ggataccctg 8460
aattttgtat aattagtgta aatacagtgt tcagtccttc aagtgatatt tttatttttt 8520
tattcatacc actagctact tgttttctaa tctgcttcat tctaatgctt atattcatct 8580
tttccctaaa tttgtgatgc tgcagatcct acatcattca gatagaaacc tttttttttt 8640
tcagaattat agaattccac agctcctacc aagaccatga ggataaatat ctaacacttt 8700
tcagttgctg aaggagaaag gagctttagt tatgatggat aaaaatatct gccaccctag 8760
gcttccaaat tatacttaaa ttgtttacat agcttaccac aataggagta tcagggccaa 8820
atacctatgt aataatttga ggtcatttct gctttaggaa aagtactttc ggtaaattct 8880
ttggccctga ccagtattca ttatttcaga taattccctg tgataggaca actagtacat 8940
ttaatattct cagaacttat ggcattttac tatgtgaaaa ctttaaattt atttatatta 9000
agggtaatca aattcttaaa gatgaaagat tttctgtatt ttaaaggaag ctatgcttta 9060
acttgttatg taattaacaa aaaaatcata tataatagag ctctttgttc cagtgttatc 9120
tctttcattg ttactttgta tttgcaattt tttttaccaa agacaaatta aaaaaatgaa 9180
taccatattt aaatggaata ataaaggttt tttaaaaact ttaaaaaaaa aaaaaaaaa 9239
<210> 2
<211> 150001
<212> DNA
<213> Homo sapiens
<400> 2
gtactttttc cttcttcaga aattgataga gaaaggctac tacatactct gaatggatgt 60
caattggaca tccaaaagga caagatggca attctcccat cttgtccttc ttcaaaagtg 120
tctagtctat actaggcctt ttgatcttgc tgaaatctat gtaaatcttg ttgagaattt 180
cactaatctt gcattgtttt ttattacttt gtagagaatt gacatatttt tgaatttagt 240
tttcccatta attaatgtga tattaatatt tattcatgcc tttttaatgc cttttaacag 300
agttcaataa tttattcata aaggttttgt aaatatttgt taatttattt tcaaggtttc 360
cctttcattg tcatcataca cacacacaca cacaattgca ctttatgctt gtgcatcact 420
catgtttagg aacacatttt ttttataatg atgacattaa aaaatactta ttggtcattc 480
aaaatgaatt tccttttcaa aaccttagtt tattattttt tttcctggtc tatctgtggc 540
gtaataccct cctcccagtg atttgtaaga acttttgaaa gttgaaggca aattgtattt 600
catcatatgt atttcaaatt ttttcttcct gtttgccgtt tgacttctag tttcattatt 660
gggtattttt tctttgactg cagaaaattt aaatttgatg gagtcacata tactaccctt 720
atgtgatttc ttttttgttt ttatgtttcc tttttcaaga ttatataact attaatttat 780
attttatttt tgaagttatt tttatttaac tttttaatct atttgatgtt tgctgtaatt 840
agtaatgtca gttttatttt ttttcttttc aggaaattag ccaaatgttc tagcaccatt 900
ttattctcca ctgaaccctg cttccatcat aaattcatgc cttaatcttc attttcagtc 960
ttgttaacta cttgaagagt tgataaatct tggaatttca gtcaatcaat taaacatttt 1020
tgaaaactaa gagaatactt taccttaaca ctgcagtagt tcatgggaga atgctcccaa 1080
caaataattc atattttcac actgtctact cacagtctgg ccaatataga gtagataata 1140
aataggcaat agatggatga atgaattgtg gaaattagga gacatctttt aatttagatt 1200
tatttttctt tggaagggag gtaggtttta atttcttgca aggttgtaat tcagtagaac 1260
aggaagggag aaactaatgc agaggaacag aaggaatgca tgagatggag aatgcctaga 1320
aatgtttgag acattgatta agtcatcaga aatggaaaca agtttagaaa caacttagaa 1380
aataatacac tgtaggtctg ataaatattg taagattggg agttttttgt taaattatgg 1440
aaaattttat atagatacaa tagtagaaca gaccacatga acccatctca tattatcttc 1500
aacaattatc aattcaaaag ttgttatcgt tatctctatc tccacacatt tcatcttttc 1560
ctccaccact ggatgacttt gaaagaaatc ctaaccattt caactataaa tattttagca 1620
tgtctctgta aaagttaaag actctataac aacaagacat agacccaata tccaggttga 1680
gtaggagttt gctatcttac taatctaatg tattaacaaa gtctagagca ttcttattaa 1740
agtggtagag catgaagaac cttctacctg gagttaggag atttgctggg ttgaagtcct 1800
ggctctcaac ttcccacctg tgtgactcca gcaaagctct tcacttctca attccaaatc 1860
tcaatttcct cactagtgaa agaaggatac atagtagtag ttgtatccat ttcagaattg 1920
tcatcaggat tgaagtaaca gatgtgaaaa caaaactaaa attgtgaagt agtaacttcc 1980
agtccaatcc tcttctttgt aagtgatctt gaggacagac acatcacctg aaggatagat 2040
catctttgcc tagccttgtc tacaatgttc ttgctaggtt tcttttccta aaaacacatt 2100
acttaggtac ttaacagaac aaacaaacaa acaatcaaaa gacaaaacca aaaaactttg 2160
gggttataga cacccatact cataagtatt tctgaatacc aagagaagag tatttaggtt 2220
tgcttctctc aacttttcac ctttcatttc atgtaccctg tcctttgtct cagctctaat 2280
agctctgaga gctgattact tttcgggtgt cccaagtatc aggatcctgc ctagtgcaac 2340
tcaaatttcc aaaagttaat ttagtggcct tttggtgacc agagcttcag ataactcaca 2400
gggaaacaat gtttatttcc tctcccacta acagtcacaa aaaatcataa aaaagagtag 2460
cgggggcagt tttgatggct aacccctctt tccatccttt gggggaaaat tgctcatctc 2520
cctataggtg gaactctaaa gacaatgtat tcctaaaagg ggccatctgg gcggtgtcct 2580
cttttcccag cgccctgatt tctattctta gatctggaga taggcggctt tcatttttcc 2640
tgctcccagt tcccagacct tccgtggggc cgcaggatcc ccggctggcg ggtcgcggag 2700
ggtggccggc cgggctgcgc actgcgcgcc tccgctgcgg ggctccgggc ctgtggactc 2760
agcggagtcc gctgagtcag tttcttcccg cgcgactccc ggccgcgccg ccgctgcggt 2820
ggaatctggt cccaggaggc ggcgtccgcc cggggtccgg tctaggcgtg cgtgggggcc 2880
acggtcacgg tcatcccagc caggcccggc tccagcagcc ccacggccgc cgccagagtt 2940
ctgcgcggcc cgtcgcctcg gcggagcctc tggcaggccc ctgagctcgt ttttggggcc 3000
tgagtggggg aggaggaagc cgagcaggag ggctccggag agggagggca acgcggggcg 3060
gggagctgcc tccttcctca taaacaggcg ggcgtgggcg ccgatggggc ccgcggggag 3120
cgctggctgc gggcggtgag ctgagctcgc ccccggggag ctgtggccgg cgcccctgcc 3180
ggttccctga gcagcggacg ttcatgctgg gagggcggcg ggttggaagc aggtgccacc 3240
atggctagtg gcagctgtca ggggtgcgaa gaggacgagg aaactctgaa gaagttgata 3300
gtcaggctga acaatgtcca ggaaggaaaa cagatagaaa cgctggtcca aatcctggag 3360
gatctgctgg tgttcacgta ctccgagcgc ggtaatcact tgaaaataaa ctgtgctttt 3420
atttttgcaa actttctccc cctccttaca tttgcaaatt ttgtcctcct ccccttgacc 3480
ctgctcaaac ccggactctt aaggagccgc aaactcccat atcctttcct tagggcagaa 3540
agcagctgag aatttcagga aggtcttcac ctttttgact tttctccccg tttcagacta 3600
aaaaggagag ggggtgctgt ggattgtgac tttgcttctt ttccccaccc acttgttttc 3660
cagcctccaa gttatttcaa ggcaaaaata tccatgtgcc tctgttgatc gtcttggact 3720
cctatatgag agtcgcgagt gtgcagcagg taaaggcatt gttttcactt caactcattc 3780
tcccttctgt ttggaaggag acgttttact ggcaatgtta atatagccga gagttcttgg 3840
ttattcccaa aatttggctt gaggaacctc tgactgtgat tttaagatgg gaatattgtt 3900
aaatcattac gcaatgtaaa cgggatgaag agccccagta tgtgttccct gagtgtcttt 3960
aagaagtaac tttataaaac caacagtatg gatggtggta gaaggaggat aaaaatgggt 4020
tcggttttag tctcgttatt ggcaagatga attcattagt gtttagactt gactattcca 4080
agtatcttcc caatacagag catgtcctag atgagaagat tatgaatagt ttggaaaagg 4140
ggaataatta atagtgataa aatgcaactt tgtcactagc aaactcttgt agagttcagc 4200
actttttaaa attcaaagat ttctagcctt tagttgtagt ataccttgta gtatctaaag 4260
aaagtgatgt cttatgagac cctcatagtt tgcaactgtt gtcatataaa atgcatgtag 4320
aagtgaaact tttacaatct gtaccatagg aaacccagaa atttgctatg tatcttggat 4380
ttttttttaa agggggcctt aaaaatggta attaagaatg atttacagtc aaaacaaaat 4440
tataggccaa ggtgataact tccttcggag cacttagaga tttggggaac tgaaatcagt 4500
tttgtcatct gcatgttaac tcatgcagag aaagagaatt ggactttgaa ctccttggag 4560
gtgcagtcag aaagccaatg tttcttaatg gttgagaggc ttgacagaca tgaggcatct 4620
caatctttaa agtggtgtgg gtctatcttt atcttgatgt ttatctctgt atctagctgt 4680
atctagtctg ggtgaaccat ctagcttctt tgatatgagg acatttacat ctggaagaaa 4740
tattttaatt tgttttcaac tgtgaaatat tttccatctg actattatag attttcacgc 4800
tgctatcaaa ccaaaccaag aaaagatgga ggcataataa agatgctgtt cttttaagac 4860
tcaaagtcgg aattttgcct gtggaatatg agtcactttt tgggcactgg cctattgtgc 4920
ttcctgctct gcacccacgt catcccttct tacttgtctc tgctttggtg ttcagaagtg 4980
cctgattctg gccaccttca ttccctagac tctgtacttg atagagtcac tcctgcttga 5040
tactgctcag gacagtcaga tcctgggtag gcgttttggt ctgcagggtc tagataaggc 5100
agtgctatac ttgacaaccc aggggagcct ggaacatact tcctaattct taattttaga 5160
aattgcccaa gcctgagcat acttgtccgg agtagttatg agtgtcactt agtatttctg 5220
cctagagagt accagaggca aagtatgctg gaaaataagg aagagttttt ttaaaagtaa 5280
ttaattactt ttttggatat atcatagttg tatatatttt ggggatacat atgctatttg 5340
atacatgtat acaatgtgta atgttcaaat cagggtaact ggaatatccg tcacctcgaa 5400
catttttctt tgtgttggca acgttgcaat ttctttcttc tagctatttt aaaatatgca 5460
atgaattatt aaccataatt tccctgctat actattaaat attaacttaa ttgcttgtat 5520
ctaattatat ttttgtacac attaaccacc ttctctttat ccctccccat cctttcattt 5580
ccagtctctg gtaaccacca ttctactctc ttcctccatg agatccacct tttccgctcc 5640
tacatatgag tgagattatg caatatttta tttctgtacc tggcttattt aatttaacct 5700
aatgacctcc agtcccaccc atgctgttgc aaatgacagg atttcatttt ttatgactga 5760
ataatattcc attgtgtatg tataccacat tttcttttat ttttagttaa gtaattaatt 5820
tagagacagg gtctcactct gttgcccaga ctggagagca gtggtgtgat caaagctcac 5880
tgcaggcctg caatcctggg ctgaagtagt cctcctgcct cagcctccca ggtagctagg 5940
actataagca tgtgccacca tgctcagcta attttttttt ctttttttac tttttgtaga 6000
gatggagtct tgctatgttg cccaggttag tttcaaactc ctgacctcaa gtaatcctcc 6060
tgcctcggcc tccatatttt ctttgttaat ctgttgatag acatataagg tgattctgta 6120
ttttaactat tgtgaacagg gctgcaataa acatgggagt tcagatatat ctttgatata 6180
ctgatgttct ttttttggat atatacccag cgatgagatt actggatcat atgaaaattc 6240
tctttttagt tttttaagat acctccatac tgtgtttcat catggctgtg ctactttata 6300
ttcccatcag cagtgtacca ccattcccct ttttctgcat ccttaccagc atttgttatt 6360
ttttgtcttt ttgataatag ccattctgcc tgtggtgaga taatatctca ttatggtttt 6420
gatttgcctc tccctaatga ttagtgaagt ttaggatttt tttttcatgt acctgttagc 6480
catttgtctg tcttcttttg agaaatgtct atttggatct tttgtccatt taaaaataag 6540
actttttttt tttttttttt ttttgctaat tgagtttttt tagttcctta tgtattctgg 6600
ttgttaatct tttgttgaat ggatattttg caaatatttt ctccctttct ttatgttgtc 6660
tcttcacttt gttaattatt ttctttgttg tgcagaagct ttttagcttg atataatccc 6720
atttgcctat ttttgttgta attgcctgtg cttttgaggt cctaccccaa aaatcattgc 6780
acagaccaat gtcctgtagc atttccccag tgttttcttc tagtagttgc atattttcag 6840
gtctgagatg taagtcttta atccattttg aaatgatttg tgtatatggt gaaagctgtg 6900
gatctagttt ccttcttttg cacagccaat atttgattct cactgaaatc tcactgccct 6960
cctggaaata ttaccggatg ttttactgtc atagcgaagt gagagtaagc tgctcactga 7020
ggatcaaaga gcttgtgaca gacctaagac tcaagtcttc tcacaccttc aaaatctctt 7080
tccatcatac aatctactag ctgctgaatt cgcaagcttt ttgtgcaagc tagtaaaaag 7140
caaaatggtt tgatacaaat actgtggcca tgctaggtac aatgacatca atttaaatta 7200
tcattggtct taacaagggg atgtagaaag gggtctccta ctgacatttt aatactcact 7260
taaaagtagt atttttcctt cagatttctt tatattatta gtataattac tgtaagtatc 7320
ctttactgct ttatatgttg aattagctgg aagtgccaaa agaaaaactc ttaatgataa 7380
atttaaggta ttaaggtaaa tttctccttc atttaattta atagtaattc ttaattacta 7440
tttaaaataa agattaaggt ttgtttctag atgccattta acatgatatt ccagactgcc 7500
agttttattt tcaaagtttg tttcatattt tattaatgtt tcttcataaa tgacagtctt 7560
tagaaaattg acggttaagc taggtgcttt atatttttct tttcctgcct atcttttcac 7620
tgtgctccta aattttacat ctctttattc tcaagggttc aacctttgaa gaaggggagc 7680
aaaataaatg aaagtggcta aaattttttc tttaacccct agactctttc ctgttgtgca 7740
ttaattacat gcttgagttt ttagaataat tataataaag taaaactacc aatttaattg 7800
tattgtaact gtgcaagatg ggaaccttct ctcttagaga gataagcttt taattgaata 7860
gattaatgga tcaattgtta cctctgcttt gctgccagag attctattta atcacagaag 7920
ttccatgtag tgctggagag ctcagttgcc tgaatctttt tgcaaagcgt ttactgatac 7980
tgttgcttca ccaaccaaaa caaacaggtt ttttccttga gtcagctttg taggtacaga 8040
gatgagtttg gcatcctatg tgactttttt tttttttttt tttttttttt ttaccaccag 8100
aagctgttca gaatgttatt ttcttaaata gttcggaaaa aagtcttgat gtattctatg 8160
aaagcacaaa aatagtcagt ttctatgaca gctggattgt caacgtctgt tcagcttacg 8220
tggaggagga tgtcctactt gagtagtata ggtagaaata gctatcagaa attgccgcct 8280
ttgaaagcaa tttgaaatta tgtaaaagga agtaatgaca aaataaagca atttatgttt 8340
aatctggaaa agatccaaaa gtaatattgt aaagagatct tgagtaatca tttttatctt 8400
cctaaaatag ccgttgttta ctcccgtaag cgagtaagaa acttgtgcca ttattcctta 8460
ttgggtgcat atagatttct caccttgtca ttcaactcct tgcaatattc aactttactt 8520
atgcatccag ccttatccca aaatagcctc ttccctgtag cagcttcctt atcatgtagc 8580
agcctactct cctcaccgct catccgttct tatacaatct ggcttaagct ctacctcttc 8640
atattatatt cttctctgag taatttcaac tcacactgag tcttactttc agtatttcta 8700
ttatattggt atttattaca catcacactt agatactttt ccattagtct ctagagggta 8760
catatatgca ctttctcttt tttttttttt ttttgaccat gtcaagtata gttctatagt 8820
ataatagaat gaattggaga tcctttacat ttagagaggg aggagtctac agtaggaaga 8880
ataggttaat tttcatctcc ggtttgaaat caggactttc aatttttttt tcagaggtaa 8940
agagcaactt agtcaagttg gcatcttgta aacagactga gtgaagatat acttaaaatg 9000
catctataat ttcatatttt atttcgaaat gtgaaagagc ctactagggg tgtctgtgat 9060
ctctagacct tatcaattca ttctagagaa atctggaggg agccattgag gagttctacc 9120
tcctgtctat tttatagagc tctttctctt tttctcctat cagatgtaga ttcaattgct 9180
aaaaatgcca cgtttcttgc ctctattatt ctagcttcat tacttgggga gcagccattc 9240
tgataactta cattttgcta ctaaaatctc caacttcacc taatccttca ttataagcca 9300
cttcattttt tcctataatt aaaattttaa atatgtggag gaaattctgt caggtagata 9360
tgacttaaaa cctactaagg gccaggtgca gaggctcacg cctgtaatcc cagcactttg 9420
agaggccaag tcaggaggat tgcttgagcc caggagcttg agaccagcct gggcaacaga 9480
gcgagacccc tgtcttcaca aaaaaaaaaa aaaaaaaatt agctgggtgt ggtggcacat 9540
acctgtagtc ccagctactt gggaggctga agtgggtgga tcacctaagg acaggagttc 9600
taggctgcag tgatctatga ttgcaccatt gcactccagc ctgggtgaca gagtgagacc 9660
ctatctcaaa aacaaaaaca aaaccaaaaa aaaaaaaaaa acaagaaaaa aaaagtacta 9720
aggatctggt atagccattc ttgcacttaa taatcttggt acaacctcta aaactatttt 9780
ttatagttta ttttattttg ccttatttag acaattggca tgtctatgtt cttcataatt 9840
tagaaattat atgtatttat atatataaat tatatatatt atatattatg tataaattaa 9900
attatatata tatataatat atatatattt gaaatggatt cttgctctgt catccaggct 9960
agagtgcagt ggcacaatct tggctcactg caccctctgc ctcctgggtt caagcgattc 10020
tccttcctca gcctcccgag tagctgagat tacaggcgcc catcaccatg cctggctaat 10080
ttttgtattt ttagtagaga ctgggtttca ccatcttggc cacattggtc tcaaactgcc 10140
ggctgaaatg ttgtattttt tgtatgtctt tctggtatga tttttggaga aaggtgtatc 10200
ctaagaatac ggcttgcttt tgtttctggg taagcatttt agggtatcat tttgttgtat 10260
aaccattgtt tacaagtgag ataagcatct attccactaa gattgaagag attcatgttt 10320
gactgagtat gctctattaa cattctttaa aacatgtgaa tatatgtctt tcttgttttc 10380
aggtgggttg gtcacttctg tgcaaattaa tagaagtctg tccaggtaca atgcaaagct 10440
taatgggacc ccaggatgtt ggaaatgatt gggaagtcct tggtgttcac cagtaagtat 10500
gatagatatg taaaacaaat ggccttgagt atttatttgt acacatgaca accttccctt 10560
gatacactgt gtttgcaatc caaggctact cctgtggaat tctttaaaat acagatattt 10620
ttccttgagt caatgattta catttataga gagctttaaa ctcagaagtt tgatttagaa 10680
agcaaacatt taaggtaaca tgtcagaagt tattatttta ataatataat catataatta 10740
taaaactggt taagttgtag atttttgatg agtacttttg aattcaaacc atgaagagat 10800
tttggctttt aataatagaa tcgatacaaa ccactagttc ttaaaaaaat gggaactgag 10860
aaaagttagt tctgtaagta gtaatttgaa agttgatgtt ctactgtctt taaatagtac 10920
atttatatat atattcctat atatacagta agtttaaact atggctttca gaaagagtta 10980
agaaagagga aattaacttt cagcacatct gtagccaaat cttgatagta attttaccag 11040
ctatgttttt gcagtttgca gcataatggc ttcttagatg agactacttc cttagccatc 11100
attaattaag aaaatatttt ctcaagaaga atgtgtttcc aggaaaatac attttggata 11160
gctttgtttc ttgacagtta aaaaatatct tctaagctac tgaggaggct gaggaaggag 11220
aatcacttga acctgggagg cggaggttgc agtgagcgga ggttgcagtg agccgagatt 11280
gcaccactgc actccagcct gggtgacaga gcgacactct gtctcaaaaa caaacaaaca 11340
aacaaacctt ttgtcattaa ctttaaatct tttttatacc taatatgact tttctttatc 11400
acagaaaagg aaattgtgaa tattttttgg cttccaatgg tatatggttt atgaaaattt 11460
aatttatgaa aaattttcag gtgtttgtat tgctgatcag tgtcaagtag tgctataaat 11520
ttagacaaat tagagctatg tgtttgtcca taagtgaaca tgtctgtgct tatacatttt 11580
cccctctttg acaaatgtgt tgctcttctt gttttcagta cataaagggt gtgttttgga 11640
aagagcatat ttacaattaa ttggagttct cgtcttcaat ctaatctctg taattctatg 11700
tatcagttct aaagtataca gcatttgatg aggaattact caaaatatac cagtaattag 11760
gaattgtaac tttaaatgtc ccttggtttg ggtgataatt tccaggaagt ccaaagatga 11820
gccagtctat aacctcaggg agtgtttggg aaactcatct agtcatattc ctgtacaaac 11880
caactgttca aattaaatta cataaaagtt tatgtaggaa atttcattca ctcactcact 11940
tactcattca ctcactttgt tcatccagtc attcatcttc tattcattga atgtttttga 12000
agcctgtcct ctgggtcaga aaccatgcag ttgtgaagaa gatagacaca ctgctgtctc 12060
cagtggagtg tattagatca ctcccagcaa aaattgattg taaaacagat ttctcttttt 12120
tcaaggcctt ttccctccaa agacttacca gtactgaaga aaaatttctt ccgtggtaat 12180
aaagtcagga attgtgggaa tggtataggg agaggtaggg gcagggtgat taggaggaag 12240
gctggcagag aatcgaagac tggcttcatt caggtcctcc aattgccaaa tggagattat 12300
gcaacgtttc ttgaatacat acaaaactct agatgtggcc agctcagtct tcttccaata 12360
atgtaaagcc aaacaatgct ttgcaggaat agactagaga ttatattttg ggattaataa 12420
catagggatt aaaatcttat cttgaactaa ctaaacatta ttgatatgct aaattcactt 12480
tttttttttt tttttttttt tttttttaga cagagtcttt ctctgttgcc aggctggcgt 12540
gcagtggcgt gatctcggct cactgtaacc tctgtgtccc gggttcaagt gattctcctg 12600
cctcagcctc tcgagtagct gggactgcag gagtacgcca ccacgcccag ctaatttttg 12660
tatttttagt agagacaggg tttcatcatg ttggccagga tggtcttgat ctattgacct 12720
catgatcccc ccgcctcggc gtcccaaagt gctgagatta caggcgtgag caacggccac 12780
cggcccacta ctttttaata tatcattaat ttctctttta aaaacagtag caatcaataa 12840
tttaaatatt caaatgaatt cttaatttat atacacaaac taacatcttt attatatctc 12900
tatattttaa tatatcaaca tgtctaagat aatttataaa tttacatcat atataaaaat 12960
gggtttgctc tcgatgtata taaggcttca tgatattttg aatatggagt tgggtgaaaa 13020
tagtgaatct gaatatttga atttgaatat ttattggaaa ataagtagtg cttttaactt 13080
tttaaatgag acacataata gtcccctgtt gatttttttt tattttttta actttattaa 13140
agtatagttg acaattaaaa attgtttata tttaaggtat acaattgatg atttgacatg 13200
tgtacattgt gaattattca ccacaatcaa gctaattaac attccctgtt agtttttata 13260
agcctggttc aggtttgtag aaagaaacaa acacacatgg ccaggcacgg tggctcacac 13320
ctataatccc agactttggg aggccaaggc aggaggatca cttgaaccca gaagtttaga 13380
ccagcctagg caaaatagca aaccctgtct ctccaaaaaa gaatgaaaaa attagcctgg 13440
tgtggtggca tgtacctgta tccctagcaa ctcaggaggc tgaggcagga ggattgctca 13500
cttgagccca ggagtttgag gtttcagtga gctatgattg caccattgca ttccagcctg 13560
ggtgacacag caagaccctg tctctaaaag caggcaacaa aaacacatga gcttcactac 13620
agggaattaa atacaatgag agtaataaaa aataggtgag caaaaaaaat gcaaataagc 13680
aaacttttga gtatgatatt tcattcttat cttgatttct gtttttaact ccagattgat 13740
tcttaaaatg ctaacagttc ataatgccag tgtaaacttg tcagtgattg gactgaagac 13800
cttagatctc ctcctaactt caggtaatat gtgtatatgt tttttgtgtt gattcaaatt 13860
aaaaaaaaag ttgataccat taagtaaatg tgtgtgtgtg tgtttttttt tttttttttt 13920
tgaagatcag gattagggta gcttgattta aatgtcctaa aattgcatct gtttttagac 13980
ctagtgatgg gacagccata atataatcta aatatcagtt atttccaaaa ttctttctgt 14040
ttccatctct tctccttatc tcttttctct atactttgcc tctcaaaaat ctcattcaat 14100
acattggttt taaacattac cttatatatt atccccaaat ctctgttggt agtccgatgt 14160
ttgctcccaa aatctggacc tacatctcat attcccccag gttagtggtc attcctgccc 14220
ttgccattat tacttctttc tccctatata tctttaataa attttctata atatatgttc 14280
tggagtatgc cataatcgtt acattttgaa aacacatagt attacttctt gagtatttgc 14340
tagatgccag gcttcacaag taaaatgctt cacgtgcttt taaacacctg aatctgaaaa 14400
caccccttga gatagggatt ttatctcagt tttctaagtg acaaacactg aagtgcagag 14460
aagttgcttt ggccactaag aggtagaaac agggtctgat tctccatgtc aggttccttc 14520
cctgagaaaa ctttggcctg gtagataatg gacctgaaaa caaaaaatct tgaaatgatg 14580
caacagttgt gggcattgct gtgctggaca ctggctatta tataaggttc cgagaagaaa 14640
ggccgctcac agggagctaa tcttgaaggg ctgggaggag tttccttcca tgtaggggag 14700
ggctttttag gttgagagaa gtatgggtgc agaggcctgg gaggatagca tgagagaggc 14760
tggacgtgtg attgggaagg tttgaattgt cctcatcagt cctgctaaga gatgtaaaga 14820
ccatgctgga gaaagaggaa gatgagagta tgagggaaaa acaagaaggt actcaacatt 14880
tcactacagc tttttatgac catgttgtat ggcatgcact aagagtcttt aaccatgatt 14940
taatttaacc tcacccttgg gaggtatttt ttttttgacg gagattcatt ctccatttgg 15000
cgatggacag gaagatgagg gtttattaat atgaaaaatc taccaacact ggaatatatt 15060
gaagttagcc tcatacagta ctactactcc tattccagta ttattatttt tattgacaga 15120
atagatgctg tttgtgttaa gttttggatt atgataggaa atgtttggta tagtaaaagg 15180
caagagtgtg acatgcagtt agtccaagta cgaagagata ccaaaaaaaa aatgtttagt 15240
gaggagcaga gtttagcata tttggagtga agacaatgtg cggaaggaaa ggagctgatg 15300
agatacatgt actatagtcg gttgtgtgaa aggtcttgtt tttcatacta aggatcatga 15360
gaagatctta gtagattcca gcaagggatt tgcaagacca catttgtgtt ttagaaatat 15420
aatgcaggca ataaaccagt tggatagaaa ttggggactg tagagcaatt aagcaactgt 15480
ttttgcattc tagatgagaa tgcaaaacac aataggaatg aaggtgcctt gttcaaaagg 15540
agttttgttc aaaaggaatc ttcaagatgt gtaggagata ttcttaaagg acttggtaat 15600
gaattgattt gttgcttgga tagagaatga gaagagaaag gagggtggaa gaaggaagat 15660
gacttaggag tttctcttgg gtagctagtg gattatggta tcattgatga agacagggaa 15720
caggagtagg ccaggtttgg ggtaactgtg gaatattcag atgttgtcta agaggcataa 15780
gaatgtattt cagatgtttg gggcaagttg tctaggctag aagtactgat tgagactcat 15840
gaaattatag taaagtgaac tgggagttta tctcatttat aaagatctag agcttgataa 15900
gtctaacatc tagggcagtt aagtagttta tcaacaaaca aacaaacaaa caaacaagaa 15960
aaccatgggt ctacaaacca ttcacagtct tcatgtaaaa attaattcat gtaaaaatta 16020
acacattaaa tgttaaagca gctctttact cagagcatat tattctcttt aaaataggta 16080
aaatcacctt gctgatattg gatgaagaaa gtgatatttt catgttaatt tttgatgcca 16140
tgcactcatt tccagccaat gatgaagtcc agaaacttgg atgcaaagct ttacatgtgc 16200
tgtttgagag aggtatttta aaatgtcaaa ttccttaaag tatatataag aaaaaaaggc 16260
ttatactggg aaaagtagaa cacagttata ataagaagaa ggtttctaaa atcctactat 16320
ttattaagaa gtgggagttg tctgtcaagg gtgaggaatg gggttaattc agaagtattg 16380
cttgttttgg tggggtgaat ttcattcgtg ggttataaat catgcccctg gagtagactt 16440
tcttcaattg cttaacaagg cataaggttt actttgaaaa ctggatgtgt gggtgctatg 16500
aaagaaaaaa taaaactgtg aagccaagca taggttacac tgggattatg atgttgagtc 16560
atcaccagaa atcatagaaa ttgcataaag agcctgaagg tttacaaagt gtccttcagg 16620
aaaaagacta atatgcattt catagcctgg ccctgagatt gataactgag attattatgt 16680
aattttagag ttggttggag tccttgttta gtctttccat tgaccttagg aggaagtggg 16740
tcacagcagt gaagtgagca tcctgcctga ggacacagag cttgtgacag tacagttcaa 16800
ttagcaatta ttttaagagc cccttttgta tcattatgag agccaactgt gctaggggtt 16860
tagataagaa tgatttatgt gggccctgtg tcagttatca gtttaccagt ctaatttctt 16920
gcagttccca gaatgggata gatcacctga taactgttga attccctgtc tcctcccaga 16980
aggattttaa acagcttata gataattata atacacaaga gtaaacaaaa tggatgagaa 17040
aataggtgaa gggacaataa tataaagcta gattaagttt actgtgtttc taaggtcctg 17100
catatttaca aaggggtggg ccagaaattt gtctgtttgc ttcctatctg acaaagaaaa 17160
gaggtaaata tcagtggtta caaagttcct taagataaaa gtaaacctat tattcaggag 17220
aagcaattgg tctcatggga gatctgagaa acatcttccc atgggttttc ctggatgaga 17280
caataaagga catacatttt gcaaggaata caaagtgtat tgcagcgaga gtgactctgt 17340
caaaagtcag aatagcatgg gcctggtacc cagctctttg ataatcatac accgtgaagt 17400
agaagatagt ttacagcgag tacggaattc cttcaggctg tcatgtataa atgttctatc 17460
ttgcaactaa gctttcgatg acaattagga taaagtttga ggttctattg tcttgcaggg 17520
tctgtaatct tctgtgtgga aggttagggg cacattcttc ttcctggaag gagggctagc 17580
atcactttat caccatcgtt gtttagtcca tctaagacac tggaggtaga ccatagaatg 17640
ttacaaagaa gaatgttgct caatagaaaa accatcagtg ctgagagggt tatgactata 17700
aatgtagagt agaaaaattt ctgatttttc caggagtatc aggttctcca ggactcaggg 17760
gtgactataa agttaatttt caaaatttga aagtgtactg tggaaactag accataaagt 17820
gagaaagttc catgatattc ttcacttgtt aggaaaactt aactgatttc acattatatt 17880
atagggacac tctggcataa aattaaaaaa aatgaatgtt gatcacttag agtgctgtgt 17940
tttctaacat atttctggcg ccattctcaa gctagataaa ctataatttt atacatgttt 18000
ttcaggttgt tgcccaataa caatgactcc aaatggaact tactggcttg atcaaatgac 18060
tttaattgtg aaaattaatg atttatattt ttgctgtctg atggaaaacc actaagacag 18120
agtatttcaa agtctgatta cttgccattt gctcaagttg acaactcttg aactgaaaca 18180
tttagccgag ctgcccttca gcagcctacc attaatgcct cccttttaaa tattgcaata 18240
tgtccagttc cagttggcca tctttattag tcactgtcag ttttctctag aatttcccaa 18300
atgaaattgt aaataatttt gtttttctga gaactgcttg ctgactagca cttttacatt 18360
tcaaaacatg gagtacctaa cataggccga aacaaaatta tttgaatctc cgtagcttgt 18420
tttctcatta taacattctt aggaagggct gcttcacaga aatatatttt ttatttaagg 18480
agattacact tgatgtatct cacacaacta taatgaatat tgtaattttt gaataattaa 18540
actttcatat catctttaag cttattcagt attttgtctt tcatttttaa gtctcagagg 18600
agcaactgac tgaatttgtt gagaacaaag attatatgat attgttaagt gcgttaacaa 18660
attttaaaga tgaagaggaa attgtgcttc atgtgctgca ttgtttacat tccctagcga 18720
ttccttgtaa gtagcattta aatgttattt attttttgta tctgaaaaat tacaatatat 18780
ctcattctga gtatatttta acaatatttt tattatttag aaacttgtgg atgctcaacc 18840
cattcattca tttattcatt taattaattt acattcactg acattatact gaagttggct 18900
gtgggcttgg tgctggagaa acaatcgtgg aaaatacaga tgtgttcctt accttttcag 18960
agcttgtagt acaatggggg acacagataa gtacagaggt gattacagtg gcagaagtga 19020
tggcagatgg cagaagtacc tagagttagg agatcaaata ggaagtgagg cagtgtctct 19080
tagcaaagat ttaataagtg gagcttcctg tgcatgaagg tgtgacctga agtgagaatg 19140
caggcaaagt ggcccaggca gtgggcatgg ttaatgtaaa gatgctggag caagagagag 19200
cagactgcct tcaagaagac aaaagtagct cagtaaaggt gtggggttat gagtgtgcgt 19260
gcatgcatgc gtgtgtgccg ctgtgcatgc acatccccaa atatcctatc cgtttgtgtt 19320
tcattgacag aggcaaggga gagcttgata agaggcagta aatgaggcca gagacatgga 19380
gtggagagca tgaagggcct aaaaagccac atgaaggagt ttgaatttta ttgtgactct 19440
tgattagcat tttaatgagg ctttgaaatt tagccacatt tttcaccaaa aatattaatc 19500
agaagaaatt aatttgatgt gtatgctacc aatgattgct attaggctaa aataatggtt 19560
catattctgt tttgttttgt attaatggtt catattctgt tttgttttgt aagtgaccat 19620
taacactttg tattttatgt attacttgtg tgggtttcta caggatatac atatgcattt 19680
atctagtgat attttcatcc tcacacatgt gaagttttga ggattagagt taaacaatgt 19740
acctggtatg taataagtgt tctaaaatca ctgacaggat tattagacaa tatgtatttt 19800
atatgtgtgt tgtatactat atgtaattgc atttatggtt tcagatatgg aaatcactgt 19860
gtcaatctga aggtgtgagc cttcggtgta ggcagagtaa aacccaatgc ccttgtgaaa 19920
gaatgctttt ttttggtgat gtttataaaa tcacaatgtt ttcttatcca caggaaatta 19980
aacactggaa agtgggtggg gctgaacaat aatagagaaa ggccatggtt ttacatttct 20040
ctgagacatc actgccaaca aactgaatat gtttttcatt atactttttc cttggctata 20100
tttattcatt tatttattta ttttgggctg gaggtttttg gaatccattg ttttccaccc 20160
acattggaca taactccagt aaaaatgtgt tgattcataa tgcaaaagtc aagaaagtag 20220
cagctaaaaa ttaagaaatc aaaagttttt aaaacactga ttctaactga aaaacatttg 20280
cttttcagtc tttaagtcta ttgttctgag tcaaagcagt tcatttcctt acgttgttaa 20340
ttttttttct atgtttaagc attgtaatat actttttgtg aaaacagttg attagttttg 20400
gttgtgccaa aacaaatact aaaatgtttt gcaaacagcc tttttttaaa caaaaaaaga 20460
acagttaaca tttgatgcag agatatacat gttttctcca tgtaggttca cacctcactt 20520
cctttattga ttaattgctt tttctggtag agtctttctt tcctttctgt tttacctgtg 20580
tttgtcccta agacttatat tttaatatta tgcctcctct ctttcgttct cccatctttt 20640
cttccaccta ttttggagcc ttcaggaagc ttgattttgc tgccttgtac attggttgcc 20700
cttctggaat ggaggaaaca ggtcatagct gattttaact gttccatctg gtgacatatt 20760
cttgattttc tttcttttgg ttggggaaaa aaaaacaatg caaaagtcat tctccaatgg 20820
ggttgagcct cgttaagaaa tagaccctcc acaatggttg aactagttta cagtcccacc 20880
aacagtgtaa aagtgttcct atttctccac atcaaaaaaa aaaaaaggta agcaatataa 20940
catgagccat atctaatagg acttcagaaa ttatctatcc tatagttcca ggatgacgat 21000
gatgatggtt gtgataatga tgaagattgt gatgatagtt atatgggaga taaaacttta 21060
agcactttac atattaaatt ctataatatt caccacatct attaaaatat gttacattat 21120
tgtccctatt ttaccaacaa gaaaactgac caacaagatt aaacaacgtg actaagttca 21180
cacaacctgt aacagcagaa tctatgtcaa tcacaacaca attagcagct atttctgtgg 21240
caattttcaa taaagatgtg tctggaaaaa aaaaaaagaa atagaccctc caatttattt 21300
atctgaaaac ttatgaccaa tacattacat ttccagactt tcattttcag tacttttcct 21360
ttcattttca gtactaaaag tactctgaat ttttcctttt tttgatctta aggctttaag 21420
ccaagaaaca ggaataaagt aaattttcct taatgccaaa gattagtcct acaccccatt 21480
atgttattaa tgaacagcat agtatttttt acagctactt aaagaacatg atgtttaaat 21540
ttggaaatgc agtcattatg ctgccatcta tttacagtct atataagacg tctttgtatg 21600
catatttgaa aggagaacat ggttacctta ttgataatta tgatctcttt aaattcaggc 21660
aataatgtgg aagtcctcat gagtggcaat gtcaggtgtt ataatattgt ggtggaagct 21720
atgaaagcat tccctatgag tgaaagaatt caagaagtga gttgctgttt gctccatagg 21780
cttacattag gtgagtttct tagttaatat gtcatcacac actgtatgat atacatatac 21840
atataaaaca tatatatgtt gcataataat ggataagtag catattgaca tactttgaat 21900
gaaaatattg taaaatccca gaaaaaataa attaaaacaa aaagaaaata ctgtaaatta 21960
ccaaactgtt ctgctgtgct tagatggact tttaaaagga gtgtcaaaaa tagatgtgta 22020
gaatgtaaaa gaagtattat cttaatctta tttttataga tgtagttcta tagatgagtt 22080
tttttattgt tgaggctata tttaaaatat aattatgtaa gaattgatac atacaaaaat 22140
atgcataaca tatacaatat aaagcataat gcaaataact cactatccaa cttaaatgtt 22200
gtatattccc agtgggggaa gctaccctgg gcttcttcct gcccttgctt tctctataga 22260
ggttaacact atccagaatt ttgtgtttac aaatcttttg tttataaata tgatttacta 22320
cattttcatg tttctctaag caaaattgtt aatgtttgcc tgcttttgct tcatcaaaat 22380
gtaatcatac tgtatgttgt cttctgcaat tttcaaatat cagtgctatg attataagaa 22440
tcagaaatat ttttgcatgt ggttgcatgt agtattctat tatttggaaa taccacaatt 22500
tatttttcca tttttctatc catggacatt tggattcttt cttattttat gctactacta 22560
tctgtgttaa aacagataac tgaaaaagaa cagttaacat ttggtgcaga gatatacata 22620
ttttctccat atataaataa gggttaatat tttaaaaaat atttatttgc cattggtatg 22680
tccttctttg tgaaatatgc aatctgtcat ttatcaatat tgttcacagg atagtctgtc 22740
tttttaaaac cgattcatag attctggata ataatgtttt ggtggtaggt tatacgtatt 22800
gaaaatacct tcccttgaac atcacactct ggggactgtt gtggggtggg gggagggggg 22860
agggatagca ttgggagata tacctaatgc tagatgacga gttagtgggt gcagcgcacc 22920
aacatggcac atgtatacat atgtaactaa cctgaacatt gtacacatgt accctaaaac 22980
ttaaagtata ataataattt taaaaaaaag gagatgaaga ggtagctgca ggttgactga 23040
gcaagggtca ttgtctattt gaagtttcaa aggtatctct gaaaataaac acagtttttt 23100
gcaagagtga aaaaaaaaaa aaaaagaaaa taccttccct tgacttgtag catgtctttt 23160
caccgtcttt atggtggctt ttgtgatata gttaaattta ataatcagtt cctttgtgat 23220
ttactctttt ttatgtatct tgtttaagaa atcttaatct gtcctttccc taagataata 23280
aatatattgt atattttatt ccaaatctta ctcgtttgtt aaactgttgc agtttgtttt 23340
tgtaaagaac ccaattcccc ctcttttttt cagtgtggag agctagttac catcacagca 23400
caatttatta gaggttcacc tgtttcccag tcatgtggta tataaatatg taaacatata 23460
tgcttatgtt tctgtccttg gcgttctgtt gcattaatct gatttgtctg aatcagattt 23520
aaatctgatg ttaaatataa cactatttaa attaatagtt ctgtaagtcc tgatatctga 23580
aaagctaata ggtcaagtca ccatacattc ttttttaggc acagcttgcc ttttttcttg 23640
ggcctttact attccatgca aattacagga ttaacttgtc cagttccttg gaaaacactg 23700
ttgagatttt gactggaatt gcacaaaata tgtggatcat tttaagaaga actgacatct 23760
ttacattata atttcttcta tacatgtctt gcacatctta gtttttgcta cgtatcttat 23820
tttttattat tattgtaaat ggtatttctt tttaaatcat atttttgaac tgtgttttca 23880
taaagaaatg caaatgattt tttgtatatt gaactaacct acctttctaa actcttcgtt 23940
aattctgaca atttgtttct aaatgcactt aagttctcta cctagcaatt atataatttg 24000
taaataatga cagtctgagt tcttcctttc tgcttcttat attctttatt tcatttcctt 24060
gtcttcttac atgagtcaga attattaata tagtgttaaa tagagccatt gatactagac 24120
atccttgtct tgctcttttt cctgatttta aacagaatat ttttaatatt ctcccatcca 24180
aaataatgca tcttacaagg gtttaaactt ttaaaaaaaa ttttgttaag aaattttatt 24240
ttatttcttc tttgcttttg ttttttcaat gtgggctttt aaatgtttgc ttttattttt 24300
acaatgtggg cttaaaaata ttaaaatatt taattttatc aaatatactt aaaatgtagt 24360
aagtcttttt tttccttttc attatgttaa tatgaagaaa tacatctaca ggttttctaa 24420
tactaagcta ctgtgcactt cctgataaat ttaacttggt catttattag atttttaaaa 24480
acacttctaa aaaatcttct ctgtttattt tcacatatac caggtgagtt ttggcagcct 24540
cttgtttttt cttttttacc ctttcttttt tgttaaaaac atccttttat ttatttaatg 24600
attaatacat ggctattttg tgttttgtat ctgataacta tatataaagt tctggggagt 24660
ctaaaccaac tgcttctagg ctgactgcct gtcagttgcg gagccttgtt ttcttgtatg 24720
gttgtgagtt tctcttttat tgagcatcct gaggacttaa attaaagatg ctctttcaga 24780
ggtgtttgcc aggagtcaga gcacaggact gacctgggag cagtttagga tatgatccag 24840
gcttaatatg ggagactctg gttgagacct taccttgcag agagtctgaa actggtttgt 24900
tgaatgcagc gccaggattc atgctttccc acaagactac tctggcgttc aactcacagc 24960
tcttgtttca gcttcttttt gaactccctc tgcccctcaa cacacacctt ggaaatttcc 25020
ttgatatttt tgtgaggaca acaatgcatt taaaagtgag agtggttgct gaataataag 25080
gaatgatcgt taactgttgg acattgattc tgatgacatt ttctcaaaag gataaccagg 25140
aatattttgt acaaaattag gattattata ataggcattt agtttttcat tgttacaaat 25200
tttgaggaaa atcattaatc atttgaaaaa actaattgac atgtctccat tgtagcaact 25260
tgtattttca cttctagtat catgattata tcccctgtgt aatttggaaa ttgattttag 25320
cattaggaaa tttcctagtt tcagttaaaa tgaatttttt gtaagctgaa ttctatttta 25380
catgcacaac tttagtttgt tatttctttc cttgacaagc atttattgaa tgttgttata 25440
tgactaaaac tgtaagatga taatgtttta atattttcac atttctttca tagcttccaa 25500
agtgtatata tatactcaca tacttcatat atatgaatct acttatatac tgtatataaa 25560
aatatgtata taaatatata cacattgtat ataaatgtgt atatatattt acacatgtat 25620
ataaatatac atacaaatgt atataaatat acatatttat acacagatgt atataaatat 25680
acatatttat acacagatgt atataaatat acatatttat acacagatgt atataaatat 25740
acatatttat acacagatgt atataaatat acaaatataa atatatacat ttatatataa 25800
atatacatat ttatacacag atgtatataa atatacaaat ataaatatat acatttatat 25860
ataaatatac atatttatac acagatgtat ataaatatac aaatataaat atatacattt 25920
atatataaat atatatattt tttgatacgt acaactatct tgggagatgg gatattgtta 25980
ttatttccac atttacagat gaggtcctgt ggttcatcaa tctttgtgtt ttattcaaga 26040
ttatgtaagc agtaagggat gaaatcaggc tgagaaccca aatttcttca tccctaaaca 26100
aagtatttct tctaaacatg gtatccattt actagtttat ctctatcagg tgacccttta 26160
ttcattattt ttcatgagaa ggttgtagtt gtacaaagtg gctgatatct gataatgttt 26220
taatctaatt caaagtcgat ttcttaaatc caggtgtcag agtagcacac tactgtacaa 26280
ttctctgttt catgttttac aatttaccac agtcaagtta caacttgcac atgttacatt 26340
aaaatgtgaa ttcaccttaa tttcttgaaa tgagccagaa gaagaagtgg ttttgttttg 26400
tgatcaggga aatgctactt gactgccaaa ttgtctagaa cagcacatta aagttgcttg 26460
attttatact gttaaaatta aataaaacat ggcaactgtc atgtcatatg taacttttgt 26520
attattctgt aacttttttt gaaaataaaa agtgatcaaa ttgatcttca ggtaaagaat 26580
cttttttctc ttgattatct cttagtggat gatgatttgt tccatttaat gggtagagaa 26640
tttattgttg ctgttattgt ttcaaaagta gctgaatgaa actcttaact ttttcttcat 26700
agttaaaatt aaaacctcaa gtaaataaat atttaacgtt ttgccaaact atgtaatcta 26760
attatgggct taatgcattt aaaggctttg tataatttgc tacgtatttt cacacaagtt 26820
acctgaacat aagtccagtc ttcctgctgt tttctgagtc acacagtgat tcagtgaccg 26880
aacagctgtt ggcagtggtg tgggtataat agggaaaaga gactgatggg gacaacccaa 26940
gtttagacaa gctggtaaaa gtagaagaaa atcttcttga aaacactagt gatcactaag 27000
ggctgtggag aatttttgct tggtgggtga atgtggaaga ggcaacagca tgggaaggtg 27060
ttggtaaagg agctccatac ttgcttaaac tgccttttga ttgtgaggcc gttgatgaat 27120
atttagtttg ggctttaggt tttttatgat acaggatatt ttccatttct ggctttgtat 27180
ctcagagatc acttagttac acttatagat gaataggagt ttcaattcct tgttttagaa 27240
agaagcttgg taactgttag tgagttacaa ataagccaaa tagaagaagg tacatatttc 27300
tgcagtatca ggtaaagttt ttcctcataa ggatttagac tcttggatat catattaatt 27360
ctcagaagag tgggtataaa aaggtatggg acttcttcct ggggtgggtt ggaggtggtg 27420
aaataccttt tttttttttt ttctgagatc atcatagaca agatcaaata atggtaaaca 27480
tgccaatgaa ttttctaagc actattcctt taagtgaaag aagagtgttt cagtaaaatg 27540
atttaatatt gggtcttcca aaagatggat ttaagagttt caactttaaa agacagaaaa 27600
attaagttat tttacacaat gaatattgtc gtgccgtgtg tcacagacat gacatgagag 27660
ggaatcagag aacatacagt taatacaacg caaactagta tcattacttt tgctcaatca 27720
cttccattgt ctaagtaaga taattaaagg acagcataaa ataaaatttc aaaactttac 27780
tcaatcatat taagctattt taattaaagt aaatgtttta atgccattga atattcatca 27840
ccattcaaaa ttattgatgt aaatagtgtt atatgttaaa ggtaatttaa cttccatgga 27900
tgagaattca gctaatgttt cacttaactt ttaggtaatt ttttcaatat cctggtatta 27960
aacgaagtcc atgagtttgt ggtgaaagct gtgcagcagt acccagagaa tgcagcattg 28020
cagatctcag cgctcagctg tttggccctc ctcagtaagt aacttcacta aaaaggggat 28080
tcttacagag gcatttgaca tcaaatatga acattgtaac aagagaatca tatgtacaga 28140
tggaagcatt caatgccttt tctgtcctgt gtagctcatt ttccagtaga ggatactttc 28200
aaggaaacta acagttgtga caaatataca catctcaatg tagagttttg ctttacatca 28260
ttcttgattt agctttgtca ttaagcagct aatctgtttt aaaaaaattt ttatttgtgc 28320
ctgggcatgg tggctcacgc ctgtaatctc agaactttgg gaggccgagg cgggtggatc 28380
acaaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa 28440
atataaaaat tagtctggca tggtggcggg cacctataat cccagctgct cgggaggccg 28500
aggcaggagt atcgcttgga actggagggt aggagttgaa gtgagctgag attgtgccac 28560
tgcactccag cctgggcaac aagaatgaaa ctccatctca aaaaaaataa tttatttgtg 28620
ttttaagttc tggtgtacac gtgcaggatg tgcaggtttt tcacataggt agacgtgtgc 28680
catggtggtt tgctatacct attaacccat cacctaggta ttaagcccag catgcattag 28740
ctatttttcc taatgctctc ccttctccag tcccatcccc taacaggccc cagtgtgtat 28800
tgtccctctc cctgtgttca tgtgttctca ttgttcagct cccatttata agtgagaaca 28860
cgcagtgtgt ggttttctct tcatgtgtta gttatctgag gataatggtt tccagctcca 28920
tccgtgtccc tgcaaaggac atgagataat tcctttttat ggctgcatag tattccatgg 28980
tatatatgta ccacattttc tttatctagt ctatcattga tgggcatttg ggttgattcc 29040
atgtctttgc tcttgtgaat agtgctgtga tgaactaatc ttttcaaata atcctcctct 29100
cgtctattag gttttttttt tttttggtac cttcttcctc attttattat ttatctggat 29160
aggatggtag cattatgaga cgtataatat attaaaaatt atctttataa ttgaccaagg 29220
cttctcctaa agcacacctc attctgttgg taatatttca aaatatggac ttagagttgg 29280
tcaaactgtt aagtagataa tatatataat gtttttatat atttttcaat ttttttcaag 29340
ctgagactat tttcttaaat caagatttag aggaaaagaa tgagaatcaa gagaatgatg 29400
atgaggggga agaagataaa ttgttttggc tggaagcctg ttacaaagca ttaacgtggc 29460
atagaaagaa caagcacgtg caggtaggac tctcataaat attagagtta ttcaaaatta 29520
tgttttccag tcatttatat tttgacagat ttcttttttc tcccctaatc caggaggccg 29580
catgctgggc actaaataat ctccttatgt accaaaacag tttacatgag aagattggag 29640
atgaagatgg ccagttagta gttttgattt tatatgatag aaaatttcag ttatatttta 29700
aatcaatacc tataaaatac cttaaccgta acttttattg ttagaaatat ttttgatata 29760
ggcatttagt tttagatgtt gctgcaaaat agtagtaggt atgtagtatt ttgatctcat 29820
caccttcagg agttagaaaa ggtagaatga gagttattat tgagagattt ggaatcaagg 29880
gtcatttggt aattcatgaa tcatggagaa agaatctttc tattttctgg ctgatcgttt 29940
taaaatgcca tattaattca tcttgggtga tagaaattgc agagccatct gtgatctttt 30000
cttctatggt gactagccag caggttgtca atatcagaaa ttagatttgg ttagagagct 30060
tcctatgatg agttcccaac tgatgtgaca gagttgacct gtcttctttc gagagggtta 30120
tttgaagctg tcatctctgg ataactcttt caataggagt gccattcaaa catcataaga 30180
ccggcactct ctcccaaaga tacaagctgt agcaaggagt tttgtgcata tcaggtttgt 30240
ttcatatccg tgagcctttg tgttttatgg caactgattg attatacttg tgctatttgc 30300
aatgggtatc ctctgggttt taaatagtga atgacttatt ttggaaacaa atagtagtat 30360
tctatgtctg aaatcttgac cgtctatttg tttaattatc tattgctgat aagaagggaa 30420
ttaataacac agatgctact taattaaata ttttcatttt gacaagaaac agtaattctt 30480
ttgaaaacta tgctaaattg gcatcttaat aatctcatgt tgagcaaggc ttttggagat 30540
tagggtaagg gagattcatg tcgcagttta taaatttcag ttcataggat acctattttt 30600
caatatccat aagataactt taaaataaat atattattaa aacaaagaaa atatatttac 30660
gttatacatc tttaaaacct accttgcttc tttacaattt tcagtttttc ctctcttgtt 30720
tccattctct tctcctcact ttaccttttt cctcagcatc tctttacata tctgctgagc 30780
ttttttattt ctctctgctg catatgcttt tgaaaaagca taaaaatact aatttgttag 30840
gatttaatta attcgagtct taaaaaatga actataattc actcttgtaa gtggaggtgg 30900
catgaaatat tgtttatatg ctcttaattg ttgttagaga tatttgataa tggcaagtga 30960
gaatttgaga tagttattta aaagattact actaacattt tgtttgaatt tttgaaagtt 31020
tcccagctca tagggaagtg atgctctcca tgctgatgca ttcttcatca aaggaagttt 31080
tccaggcatc tgcgaatgca ttgtcaactc tcttagaaca aaatggtaag cagtgggcca 31140
tgttttcaaa taaagggaaa cacatttttg tggtattttt aattatagaa gctatatact 31200
gtgaaaaatt tacataattt ataaagctat atattgtgaa agatatctct atgtgtagag 31260
atgtattgac atatggatta tgaatatata ggtaaaagga tgaagaataa aataaacatt 31320
tgttgtatat ttttccggac ttctatgtgt aaactcacac atgacatata caaaatttta 31380
tgtattttgt agaaatggga tcatattata ctcttttata accaaatttt atttattctc 31440
ttttttatgt tgatacatgt gtattctcac attatcattt tatttttaat tttttaaatt 31500
aatttttgtt tttagatatg gtctcactct gtcacctagg ctggagtgca gtaccatgat 31560
catggctcac tacaacctca aacttttgga ctcaggtgat gctcccacct cagcttcctg 31620
agtatctggg actacaggca tgcactgcca tacctggcta attttttgca gagatggtgt 31680
tttgccatat tgcccaggct ggtctcgaat tcctgggctc aagcaatcca tctgccttgg 31740
cctcccaagt gctgggatta caggcatgaa ccactgtgcc cggcccaaat tataattttt 31800
aatagctttg tagtttttca gtgcttgcct gtattctgtt ttatgaacca atttcttact 31860
gatgaagttt tagtttgtgt ccagtgggat gtttctggaa cccatagtaa acaccagtga 31920
tcactttcct cctctgtttt cctttataca tggttcctat tattttcttg ggaaaatttc 31980
atagaaatgc aactgggtag agagctattc accattttaa aatctggtaa aattgtctat 32040
tataaatttc cacactatac ttttttaaaa aatcgttctt taatgtaatt cttataaatc 32100
ttatagcttt gtataattat gaagagaaaa atggcttgta tccctttaga aagacatgag 32160
ttttaagatt atggttcagg ctgctcaaat ttcttccccc ataaacagga atactgccag 32220
aaatccttag gtgaaaactc atcataaagg cattgggact tggcagcttt tgcaggacat 32280
ttttagaggg caaaaaatag agaaaaacac tgaaagtcag agacagagac cagtgtaagc 32340
atcagctttt aatagagaaa ctgggtaggg tggaaaaaaa ataaagcaac cacctcatgc 32400
atgtttcttt atattattat tgaagtcaaa taaagaggaa aatcatttct tcttcctctt 32460
cctccttttt catctcacct ctccaatggc actttaataa aacgcttgga gtggccaggg 32520
cactgacaga cagacagggg ctgctctcaa ggataatgag tcaaagggga aggagaggga 32580
atcgctgttc tcgaatctct cttattctac tgtgcagtta aagaggtctg gacagggatt 32640
tcactcctga aaatgaggac tggactttgt ggcttctgtt ggggcacctt tagagtggag 32700
gtagactttt actatgtaca gacaacattg tgttggtgac atcattcata accacctgga 32760
aatctccttt gatatgcaaa tcaaacaacc ataactttgt gaaatttcga ctgcttccta 32820
ttgtggtgtc tgaggactgg ttacattcag agtccaccct gatgtctttg ttcagttttc 32880
tgctctttct agttccttac ttctttgttc ctgatcacct gtcaagtaaa atgtcctcag 32940
atccttttgt attgtctttg gagttctgcc ttaataaagc atgaagaact tgagtagctc 33000
gttcatcaac tttcttgggc aatttctcat tgaaagacac ttgggtgtct ttgggtgtgc 33060
agagctgagc atggctttat gtttttagaa aaaatggcta cattggcagg cagaagaact 33120
gcgtccttgg aatcatggag gtcccaaggt tgcatacatt ttgtgtgaca tttttcctat 33180
tcaattaatt aactaatatt tattgagctc ccaagtgtgt agtgtctgta ggcacttggg 33240
atgcattcat taagtaaaaa tcccaggctc atggagttta aactgtagta gggaagataa 33300
taagattaac taaaatatgt aatatttgag gcagttaaga ataaaaaatg aagcaaggaa 33360
ggagaatatg atatgttaga catcagagga gatgaagttg tgaataggca gccaggaaag 33420
aaggtgacta ttgagtaaga cctgcagggc gtcgcatatt gttttttgcc tctgaaagca 33480
gttaatttcc tgttaaaatg gagtggatga gatcaagagt attacgtaga tagctggtaa 33540
atgcgatagt gtgtaaaatg ttctataaag tctaacgtga ctttatgatg aaatttcttc 33600
ttctaggttt attgcttgca attttcaaac cacacattgg gttactgtct aggatagtga 33660
ttcttaaagt gtggttcctg gaccagcagc atttgctggg ggaacttgat aaacagtgta 33720
aattcaagga ccccatacag accttctcaa tcacaaaccc tggagttgag acccagcaat 33780
ccatgtttta acaagctctc caggtgattc tgatgcacac taaagtttga gaaccactaa 33840
cccagtgtca tttttgtctt ttaaagtgtc ttcttggcta gaagctagcc actttgggaa 33900
aggttattac aacttctgat gtgatcaagc aaagtaacca actctttatt gtatcttaat 33960
atgtgatatt ctgaatgtgt ttaaaaggta tgagtttttc aggctctggc agtattttag 34020
aatgtgtatg tgatttctat ttatttccat gttttgtcct atcttcttaa gatagactac 34080
ttattttaaa agcagtactt aagttaaaac tttttatgtt tctttttctg ccactttcaa 34140
agtgttgaat cacagtgtgt aatgttggaa ctgatatttt tatagcggct tcaagacaat 34200
tgatatttat gtggaaactt gaagacagta ggtttatgtt tagtgaagga agtttattac 34260
aaagaggaaa attggccagt tgtggtggct cacgcctgta atcccagcac tttgggaggc 34320
caaggcagga ggattgcttg agctcaggag ttcaagacca ggctgggcaa catagtgaga 34380
tcccctctct acaaaatatt aacaaaaatt agccaggcat ggtggcacac ttgtagtccc 34440
tggtacttgg aggctgagac aggaggatca cttgaggcca ggaggttaag actgcagtga 34500
gctatgatca tgctactgca ctccagcctt ggcaacagag agagatgctg tcacaaaaag 34560
aaacaccaac aaaaaaagag gaaaattatt ccttaatcat tattgctgga atatagttac 34620
tttccacaaa tagtgaagtg ccagttgtaa agcatatcta tatgtttcct agactttggc 34680
attactttgt gaaaataact gtaattactt atgttctatg taaatgcttt ccattcattt 34740
gtatatgatg gcatatatag aaattataat gtttgtaaag tccactggga taaatggaca 34800
aagcagctga aggctgaaag caaccaagcc ttttacagcc ccttcattcc ccacactccc 34860
aaaaagctga gtgaatggtc gatacctcca catgcttata actcattccc agcccaccag 34920
tgtctagcat atctggttag tcttagcttt atataagtgc agttatttgt gaacttgttt 34980
taagtattgg aatacaattt aactttcatt cttattttgg agaccattat ttaaacagat 35040
ttcttttttc ctgcaaaaac actcttttca caatggacag agacacggtg attacattaa 35100
aaccatctac tctatgaata aaaatgttaa aaccaaaatc ccaacaaagg gttaataaag 35160
gcaaaaaaaa ttggaaatga catgtgtttt aaagaaataa acatgaatta tctttaagct 35220
gtcaatgaac tataaattat gtgtgctctt gtatatgctt tcctgtaaat ttggactata 35280
ttaatattct aaagcttatg gtaaaattat gaaaatatgc tttcatatct ataagtaaca 35340
ttttaaaaaa tctcagttaa tttcagaaaa atactgttat caaaaggaat acacctgaat 35400
gttttggagt taatgcagaa gcatatacat tctcctgaag tggctgaaag tggctgtaaa 35460
atgctaaatc atctttttga aggaaggtaa tatagattca ttaacttgta cagaatatat 35520
catattgggc caggtagaat atcaatattt caagcatatt tctaacaatg aaaagaaaaa 35580
gaaaaacata agacacttga aaactgaagc attttgcaat gtaatctcgt gtcactagta 35640
ccatagactt actttatctg aacactgaaa ggaatggcaa gattgtggaa acatgttgaa 35700
ggtttgcttt tgaacctgat gcttgatgtt gactatattt tgaaaagtgg taattgtata 35760
gcacatagca tacagcagtt tttctaatta ttgtgtgtgt gaaagttata aaagataaaa 35820
tcagtttatg gctaaatttt gctctttcac aacgaatata ttattccttc atctgaatga 35880
actttgtctt ctcttcctgc tctcaatcct tagttaggga aaattttaac tacatctagt 35940
ccaagtgcag agatgctaag attatatagc tggcggttag tggcacaaca gagaccatat 36000
cctttgatct atgtgtggat ggtggtgggg cagggtggga tgaggtgggg gtgaggggtg 36060
gtaggtgtgg gcagaactct catgtgtaaa aaaaataatt ggcacagaag ttgcagtgaa 36120
aactaatttt gttcctggtt ttgccactaa tttgagccaa ctgtttcatc tctaaaactt 36180
cacgttcctc attgataaag aggaatgata ataacaactt tgaaagttgt aagcttagaa 36240
tgtaaggatt aaataaatta atttttacaa agggattagg ataatgcctg ctgcatttta 36300
agcactcaac aaattgtgtc tattgttgtt atactgttac taagtgtgaa taaatgaagt 36360
gcatatagca tgaaatgtag cgtaactgca gacttgtaag aagtagggtt acactgtttt 36420
taacatcagt ctaactaatc tatgtttata tatctttcta agctgtattt ctcttattta 36480
agtgttgttt ttgaacactg agatgaaaag tttatcttaa atgttgattt taatggggcc 36540
ggaagtgtgc aaacctttac aaatgaggca aaaacacagc ggaataaact ccagtctagg 36600
attctgtaga ttctgggcaa ggcatttaat gtttctcgct gcatgctctt acgtaaaatg 36660
tgtacagttg cagccctgga gattccgcat tggctctgac agtgtgtctg cccctacaga 36720
actcatgtga gtcgagagac tgataagtaa acagattatt ataatacagt ctcagaatgc 36780
agtggcagta gtgtgtaaaa gacgcaatgg taagagtaga gtggactcag ctggggttac 36840
ccaaggaggg gaggctccaa tggagggatg tgtttaaact gggactttaa gttggaaaag 36900
aaggaatgta tctcagtgtc cacagaacca tgcaaagtga gaacatggtt ctgatatgca 36960
caagtttcag ttaacaagca aagcaaggat tgactgtatt aaagttcata gtacctactg 37020
cattctagtc aagtgacatt tgctcatatg taaaagaaag aatagcttaa atacctgaga 37080
gaaaccaaga ctgtaaaaca aattaaaaat aattaaaaat accttataag aagtccagtg 37140
atgttaatct ggaagaggaa ggttcgtgtg atgtaaagag gccttgtctt ggggtcagac 37200
aagtttgggt accagccttg tctctgtcac tttctagtga taagacctga atatttaacc 37260
tctatctgtc taagttcttc atgtagaaaa tggggataat aacacctacc tgctgggatt 37320
gttgttattg acccatcgta ggtcagaagg atgttgttag ttttatgaag tgaaataatt 37380
cccggattac tatgaattct atcttatgag ttcaaagttt agacaattaa aattatgtat 37440
gctcatacta ctgatttcaa atgcattttc atatagtctt tcctgataaa atatattggt 37500
tctgccctcc tgtacttatt tcaatttggt gtttatacca ttgaatcaga tcagtctttc 37560
aataagcatg ccaattttat atccccagca acacttccct ggatataatg gcagcagtgg 37620
tccccaaaat actaacagtt atgaaacgtc atgagacatc attaccagtg cagctggagg 37680
cgcttcgagc tattttacat tttatagtgc ctggtaagtt acatagttga ttgtgggaag 37740
agataacaat ttaaatggat ttttgatttt tcatgaaata gcaatattct aggcaaatat 37800
taaaagacta gtttctgtcg actaaatgta aatctttctg ttaaaccaaa aagaggttaa 37860
atatgatgca gaagagtcac ttagattaat ttttataaga aagcaatatg aattcagtaa 37920
tttatttata caaagtaact acaatgtaaa atgtggagct tttattttta aggagggtgt 37980
tcatctctga taattctttt ctatttttgt tgccatgacc tgagttcaag ctttttttct 38040
cttgtttgaa ttgtactatt agctaatttt catacctgtt ctcttccttc atttctatcc 38100
ttttcttact ctatgattga attaatcttt ctccaatgtg gcttgtactc atttacctca 38160
atggcttcca ccctccaccc acctttaatt gttactgaca tctgttatca ccttatttgt 38220
tctccaaagc ccctttaaaa cacctatgtc tgtattcatc caacacattt attaagtgct 38280
tcttatgttc taagcactgt gatgctgtta aactttaaaa gatgaattgg aaaaaaagca 38340
caactgtact attataggag cttagaggta gatggaagtg taaatagata attaacaggc 38400
agcgtgagag aggcgatgat agatgcatat ataaaaggct ttgagaatat cgatggaggc 38460
acaaataatt tcttcaaagg agtaggacag agattgtaat atttgaggtg gaagggtaga 38520
tagagctggc ctggtagaaa ggccaaggaa gacatttcaa gcagaagaaa gtgcacatgg 38580
tcgggggtga gtgaggcatg gaggataagg agaggagtgc ttggggatga gtgtggaagg 38640
aaaggctgag gcccaaagaa aagggccttg aatgcagtgc taaaaatttt ttgcctttta 38700
aaaatggaag ccaacccaag tttattaaaa ttgtttgcag attgtagtgt cacaccgaaa 38760
tttgcaacta aagacaatag cattgtggtg cagaggatga tagacaggga gagagactag 38820
atacaaggag attgggttgg aggtccatgg tagtcaagtg agacccagtg aagggaccca 38880
gcaatggaaa cacagatgag agggcagatt ggacagatgg ttgggagatc tgtttgatgt 38940
gacatcgtga tccctaagta tgagggatga tactttgttc tgtgaagttc ccaatctttt 39000
gaagtcattt ttgctttgtt cttttaaaat gaaatcttcc taaatctatc attttctcta 39060
gttatatagg tattttgttt ctctgtataa gagtattact caatataaaa gttttttcaa 39120
ggacagagct ttcttcagtc atttttttct gggcccccca gtcctctggt ggctattcaa 39180
tcagtatttt aaaaattgaa tcatggtgtc ctattcatag tttcagctta gttttgagac 39240
gtaatgtaac agatgtaatt ttacttgaaa atattattgc atgttttatt gaattttatt 39300
tttagattgt aattaaaaac aataaaaatg ccttttgatt atccttaaag ttgacagcct 39360
tattcttttg agggaggttt tgggttttaa agataaccaa aggacactca aaaaccgttt 39420
ctgttagtta ataaaataat actcttttag tccaaaagca agttttgaat acagtatttc 39480
ttttctttta ttgttcttaa actgatcctg aaggaaaatt gttagttaac aatcaatcag 39540
atgtattatg ggtgcccttg aaaataatca cttgaggact gtacttaatg taaaaaaata 39600
cattttataa gcatatcagt atgtaagtac attcttctag taggtaaagg cttaatcatt 39660
tactgtatgc taacatatta tactaccaca gtacaccata ctgtactgta cccaacgtaa 39720
tgtaccatgc cgtgcagtac cgtatcattc taggtatcaa caagtaacta tggtagcaat 39780
actccagtag ttttgaggtt gaatatgatt ctggtttgaa catgttaagt tgaggttctt 39840
atgagatacc taggtgtaca tgtattcatt tattagctag attatattca ggttttttag 39900
tggcaaagat gtacattatg gcaaatgtgt ataatttagg gtccaattaa ggatagcata 39960
ttgcatctag tgcatatatc ttaagtttct ttcaatctat tactgtactt tttctcttct 40020
actttataat aacttgttat atagacattg agctggttgc tttaagaaaa taataatgaa 40080
gacccagtta ctttaataaa atatcatttg acttgtttct tgagttactg ctagttttag 40140
aggaaataat gtgaaattct ttaagaaggg atataggcaa attgggaagt atatagagga 40200
gagtgattag ggagataaaa gcacatcaaa aagagcaata agaggaactg agattgtttt 40260
atttgaagaa gagatgactc aaagggatat gaaactctat tcaaatctac ttacttataa 40320
ccagtaacag taataatacc aaacaatatg gaggacttaa aaagtattag gcattgtttg 40380
aagtatttta agtatattat ctcttctgat tctaacagca ctccatgagg cagatattat 40440
tattattatt attttggtat tgtatggact acaaaactga ggcatagaat tgtagagatt 40500
tttaaggtca ggcctgatat aacagcacca gattttcagc ttatgcaggc tgactccaga 40560
gtaggcattt taaaataaat atttgtgcaa caatcttgtc ctgaacaact gttgtattta 40620
aagcactatg tctagaatcc ttaaggtatc gggagatgat gagattatgg atactgctct 40680
caaaaaaatt tacagtccac acgacctaaa ggactgttat gtagaaagga aattatatcc 40740
atttgaatag taggacctca agtgatagaa caaagactgg agaagaaatt tacaggaatg 40800
ttcatttggt cttaatttaa ggaagatgtt aaataagacc cattacatgt agcatgatgt 40860
ttttactact caggccagtt ttagtggtca catcttctta aggtgtaata ggcagcctca 40920
gaagttactg tggtcttgct cactggaaat gatacacaga cagtttaagg gacttgcccc 40980
agaccacacg gcaagaggtg aatgtcagaa cctctttgag tacattttaa aataaggact 41040
gaaagttgga ggagggtggt tatcaaggct gccttcctta ccatagtatt cccagcatta 41100
acaaaatcct tggcatgtaa ttggaattca gatgcttctt aaataaatga aaagcctgtt 41160
gtagccagct tacagtttgc attaatgcag attattaaag tggaagatca taaatgattt 41220
tttattaata tttatgtcta taatcttagg tttggaaaac attattcatt cataataatt 41280
ttaattatat gttacattac cacatttttg acttgtagtg tttttagcat agttcagcta 41340
cagtgtagct taataaagaa tatgattttt taaaatagca atgctattat atagccttta 41400
cagaacttct aaaaaatgac atgttctcta ccaccttaat actgaaactc aaatcttatt 41460
ttttgctacg attattccag ctactctttt ttgtctatat ttcatttctg cctttttatg 41520
ttgtggtcca agtaactctg agcttttctc atgttgtcca ttgttgcata aaaatcttcc 41580
agcatcttaa agcacagcct actcacacaa aaaagtgatt gtttgctaca gaaaatttct 41640
tcaccatcgt aattttttgc tacttcaaat tcagtaagca ttcttacaca ttatatttat 41700
tttatattca gtgatgaact atttttatag attccttaaa atttctggtt atttatttga 41760
taaggaaaca tgtactagaa aaaagtacaa cacatatatt gtgagattaa ttatgacaat 41820
ttctagaaag taacagtctg ttcaactcaa atgtttataa gaaaattctt tctttattta 41880
tttatctgtg catttaggca tgccagaaga atccagggag gatacagaat ttcatcataa 41940
gctaaatatg gttaaaaaac agtgtttcaa gaatgatatt cacaaactgg tcctagcagc 42000
tttgaacagg gtatgttgaa tataagtttt ctgtatttat actattaact aaaatattaa 42060
atttggagaa ctaggggcgc tttttcagtc taagttttct gttctccgtt tgctatgata 42120
ggaggaagtc atgtggttag agacataaga tgacagtggg gatgtgggaa gtgaaaagat 42180
atgtactaag ctaagtccag ctaagtgtat tatcaattat agatgtaggc aagattcttt 42240
tgattgccag taacataaat ccactctagt ttgctcaacc agaaagagaa ccaaagagcc 42300
atatatgcag ctagaccttg tgagtcatgc tgggtactat ggctgctgtt ttctctttct 42360
gtcctctggc tacttgtctt tcttttctgg tctcatagta tatggtttag cccatgaaga 42420
cataccagtg ttaacagtaa agtcttcggc tgggcacagt ggcccacacc tgtaatccca 42480
gcactttggg aggctgaggt gggtggatca cgaggtcagg agttcgagag caacctggcc 42540
aacatggtga aaccctgtct ctactaaaaa tacaaaaatt aactgggcat ggtggcacgt 42600
gcctgtaatc ccagctactc aggaggctga ggcaggagaa tcgcttgaac ccaggaggca 42660
gaggttgcag tgagctgaga tcacaccact gcactccagc ttgggcgaca agagtgagac 42720
ttcgtctcaa aacaaaaaca aaaacagaca aacaaaaaca gtaaagtctt ctttgattcc 42780
ctacgctcct tttcattgtt ctccggagaa ataacctctg aaatgatttg gtatacattg 42840
tttccatttt ttagcattta catatccatg ttcctacatt ataattaaag tatccataaa 42900
tcatactgag tatgaaaaag agaagaaggg aattacattt aaattgtgta atgcaaaaag 42960
tattggtgga attaagaagt tttggaaatt ttgcataaga tgaattggtt ctttattaaa 43020
gatgttaaga ataaagacat aattagtgtg aacattttta taaaaggagg agcctattta 43080
aaataattaa tggaaatgat tccatgtgat ttgatatact ttgatgaatg tcataaatta 43140
attaaagtgg cttccagaga gatctccctt aaaaattcat tttaaattga actttatact 43200
gtcactcact gcctataata tgtttgagtc atttatactc aaactttaat acaatccttg 43260
agtatggcaa gaatttatgt tgtaatgggt taaatttatc ttgagaaata tttgttgaaa 43320
ataagtatat ggaaggaagg ggttaggcat ttagaagata aataaatatg ctttgtactc 43380
ttctctcctg aatctcataa gccggttgtt gatggctgtt gtgaaacctt ggttcttttc 43440
tttaaacaag agacacacag cagaggagat gcagcatcga gtaatttatt gcaaaagaaa 43500
aagaatattt tgcaagttaa gtgaggaata gacacttata ccctgacaga attcagggtg 43560
ggcttactag taaggatgag acagcgtaaa ttggcactag gaagactccc tttgtgggag 43620
ttgtacatga tttttcataa gtgggtggga agaagtgtta ctagtaagca tattctaggt 43680
tgtcctctga gtgaacatgt gcagtagctg tacatgcttg ttcatatatc gcatgtctca 43740
taagtatctg aaatctccac ccaggggtgt gtgttttact attataatga gcaaagggtc 43800
agtctgagga caaggaaaat caaaatgtgc atgctcccca cgctacctga cttcaaacta 43860
tactacaaag ctacagtaac caaaacagca tggtactggt accaaaaaag agatataggc 43920
caatggaaca gaacagagcc ctcagaaata atgccgcata tctacaacca tctgatcttt 43980
gacaaacctg acaaaaacaa gaaatgggga aacgattccc tatttaataa atggtgctgg 44040
gaaaactggc tagccatatg tagaaagctg aaactggatc ccttccttac accttataca 44100
aaaataaatt caagatggtt taaagactta aatgttagac ctaaaaccat aaaaacccta 44160
gaagaaaacc taagcaatac tattcaggac ataggcatag gcaaggcctt catgtctaaa 44220
acaccaaaag cagtggcaac aaaagccaaa attgacaaat gggatctaat taaactaaag 44280
agcttctgca cagcaaaaga aactaccatc agagtgaaca ggcaacctac agaatgggag 44340
aaaatttttg caatctactc atctgacaaa gggctaatat ctagaatcta caatgaactc 44400
caacaaattt acaagaaaga aaaaacaacc ccatcaaaaa gtgggcaaag gatatgagca 44460
gacacttctc aaaagaagac atttatgcag ccaacaggca catgaaaaaa tcctcatcat 44520
cattggccat cagagaaatg caaatcaaaa ccacaatgat ataccatctc acaccagtta 44580
gaatggcgat cattaaaaag tcaggaaaca acagatgctg gagaggatgt ggagaaatag 44640
gaacactttt acactgttgg tgggactgta aactagttca accattgtgg aagacagtgt 44700
ggcgattcct cagggatcta gaactagaaa taccatttga cccagccatc ctgttagtgg 44760
gtatataccc aaaggattat aaatcatgct gctataaaga cacttgcaca cctatgttta 44820
ttgtggcact attcacaata gcaaagactt ggaaccaacc caaatgtcca acaatgatag 44880
actggattaa gaaaatgtgg cacatataca ccatggaata ctaagcagcc ataaaaaatg 44940
atgagttcat gtcctttgta gggacatgga tggtactcag caaagtatgc caaggacaaa 45000
aaaccaaaca ccatatgttc tcactcataa gtgggaattg aacaatgaga acacatggac 45060
acaggaaggg gaacatcaca ctctggggcc tgttgtgggg tggggggagg ggggatagca 45120
tttggagata tacctaatgt taaatgacaa gttactgggt gtagcacacc aacatggcac 45180
atgtatacat atgtaactaa cctgcacgtt gtgcacatct accctaaaac ttaaagtata 45240
attaaaaaaa aatgtgcatg ctccatacag gggcaattcc ctactggaga tagctttgct 45300
taaatgagct ggactacaat gcaaatgctg aaacttacta tattgacagt aagattgcca 45360
cagttgccgc gtcctgagga catggttact tccttttaat acctatcctg tctcattgtg 45420
agaggattaa caactgtgca taaaaccagt tgttctacat gagcacttag gagggatacc 45480
agcattgtga acatagttta agtacgtaga ggagggaaca gttaagttta ttcatggtga 45540
gtgttggtga aaagtggaag aggtaccaaa acagccgtat agataactgg ttccagttag 45600
ccaacattct ctaaagttat tagagaagcc taagtgaggt gtaacctcag cagtcgggag 45660
ccaagagagc aagtaagtgc tgtgatgtgg agaaaatcac tttgttccaa ctgagaagaa 45720
atggttgagc actgcttttc ccccatgcca gtactgacgc acagcctttc acttagcact 45780
gattatcgat aggggtgggg agttaaggta tggggaaaca caagtaacaa tattttattt 45840
caaaaacctc tccactgtaa ttcccctaat ccttcatcat ggttgaggaa aatggctcta 45900
aaaaatgaga gcaattactg tagctccaaa attctgtgat tgcatgtctt actctgaata 45960
gcaattacaa agcatcagag gatttaggtc caaatattgc agacacaaga aaatgaatta 46020
cattttaata catctaaact tggagagcag agttccaaat aaggtagaac ttgagattca 46080
actctgattt ataaagcaga gactaagaag agtatttata aagcgaatcc atgtttggat 46140
acataaaagt gcaataaaat tcaagctgaa gttaaaatct ctgtctagaa cagcgatgtt 46200
ccatttatgc ctgatccttt tagcttttcc acagatgaag actttgtcac ctgttccaga 46260
gagatatatt tgttcattat tgtttccaga gagcaaaatg gaaaataaac tctgcacatt 46320
ttggccgcat ctgtgtttta tatgcggtga cactcctgtt ctcttcagtg aggaaatcca 46380
gtaaagtaaa accagtcttc tgatgaaatg ggcacaaatc aaagaacttg tgagcttcac 46440
aaaaaccttg aagcaaaata taccaagctt aaatattgaa tgtattgatt tcagtagtca 46500
aaaacagagc tcatctgcaa aagcaacaac aacaatgaca acaacaaatt acatataagt 46560
aaaatttaaa aaaggtttac aggatgaata tacagaaaac tatgaagctt aggggtagag 46620
aggagtagtt gaatatatga aaagatacat cttttttgat gaaggactaa atttttaaaa 46680
atgaaaattg atctatgttt atgaaccatt agtaaaaata acaatagtat tttctggaac 46740
taagtaagct agtgtaaaat ttgtatgaaa aaattaatac atatgagtaa tcaggagaat 46800
tttaaaaaag agtgttgatt catatggcct aactccaaaa gataatcaaa tgtattatac 46860
aattttagta attataatgg tgtgatactg gcactagggg agagagatca gtgccacaga 46920
agggtggctc aggaaataga ctcaaataaa aatttgtaat gttatgatat tcctcgactg 46980
cgggaggaaa atagattact cagttacttg tgttggaaca actaactctt cagccatttg 47040
ggaaaagcaa agaaagctga atatttatct tactcctttt gccaaaacaa attacagatg 47100
gatgagattt aaagtctata atgaaattgg tatatgtaca tattaaaagt ttcaactata 47160
attgttatta acgtaaatga caacggaaca ccttgttgga gggaaatttg gtaatatcta 47220
tcaaaattaa aatgccatgt tttctgatca gcaatttcat tctaagaatt tttaatgtag 47280
atatacttgc tcatgtacat aaagattatt agacatgaat gttcactgtg gcatgattcg 47340
taattaaaaa tgtggcaaca aactaaatgc ttacatggta atcattcatg ctgtttgcca 47400
gatattttta tttctccacc ttgtggtgat tctggcatag tatttagtag ttaggttgaa 47460
gcatgtgact aattttggtc agggagttgt aaatggaggg aatagctggt gagacatctt 47520
gcggaatact gtctcaggta ccatcgtacc tgcagtgttt gagatagtag ttgctccatc 47580
agtagaggtc cctgagggac tacaacaagc agagtcccct cctgacctgc aacacatatg 47640
tagcatgagc aataatggaa cttattattt ttgcacccta taaaattttg agaattgtta 47700
ctgcagctta atttaatctt tcctgacaat acaataccta tcaatagaga ctaatcagat 47760
aaattatacc atttccaaat tgtatcatcc tgcataaata ttaaaaaaca atgaggtgag 47820
attcctaatg tgctgctatg gaaaaatctt caattttcta tgtgtacgaa tgtatttccc 47880
aggtattcgt tttttccttc ctgtatgttg acacattatg cacacttttg gatgaaatta 47940
atatatttcc accgctttat gtcctctccc tcacttttat cacccaattg tagcaaagta 48000
tatgtttgct tttatagctt tagctatata aaattttcta atagctaagt ttgtggttcc 48060
tggaattaag atatctgaat ttaaatctaa cactactacc tacagactat gcaccctgga 48120
caagtactta atgtcttggt tttgttatgt ataaaatgga gataataact gatttttcac 48180
ttagagttgt tgaatatttt ataagataat tcatgaaaaa gtgtcagtat aatgcttggc 48240
acatagtatg cgctcaataa atgttaatgt tattactatt agatttaaaa gtatcttttg 48300
acccctggct atagaagatg aggaaatcag agtatttgca cttctaatat ctcctgtttt 48360
cccacctact tttgttcaat aaattaactc cacattggca gggtagataa tatttatatt 48420
cagctttcta attatgcttt ctaagtttgt gtttatctta ctcctaccgt tatttggaag 48480
cagtcttcat ctcaagtcct tttgttactg ttttttcact catcttttag ttgtctgaat 48540
ttctttagaa aagtttaatt ccctgaatat ttaatgttta tattttgttg ttgtttttgc 48600
ctttatattt ggactcctaa aaaaagtttt gttggttgta aaatattgtt tttttttcct 48660
tgaagtgttt gtaggcattt cactgtgttc tagtactgaa tgttttagtg gagaagtctg 48720
aggccagctt catttgtttc ttggatattt ttgcccagtg ctgaaaggat tttttctctt 48780
gaaatccatc cactttatta gggtatatct caatgttagt cctgggatat ggtatcctca 48840
ttctagctat acattcaact tttttcctgg aaagttttct tgagttgcat ctttatatac 48900
atatacatac acgaatacat atacatggta aagatattaa ggataaagat aggtgcttta 48960
taaataccaa tttgatataa ttttggcatg aaaaaaagcc tgtggtgcat tctgagtttg 49020
gaagtagaac tggatatact tacttattac tattgttttt aatacaaaaa tggagacagg 49080
gtctcactat gttgcccagg ctggtctcaa actccttgac tcaagcaatc ctgcctcgac 49140
ctcccaaagt gctgagatta caaatgtgag ccaccgtgac cagcctaaat atctaaattt 49200
ttctctttca ttattttagc tctcttcttt ggggctatca gtcatatgat gttggatctc 49260
ttttgcctta atcttctaat ttttcaaaga ctaatccaga gaccactatc tatcaccatg 49320
ccattactca tagacaaggg acatcattcc acacatttag cttatttgtc aaaatcagag 49380
atgggattta taaaagaaaa agaataaagg gagaaaacaa aacacaaatt atctgggaat 49440
gcgagtctgt tttcctttct ttggctaatc tacttaccta gtagctagga aagaggccag 49500
catgagtatt tttccattga gctggctagc tcagtcattg gagaaaccat ttcaatattt 49560
atggattctc tgaaaaaaac ttggagagta aaaaagcata ggtggtagga tgctgccatc 49620
cttctgttgg catctccaga gtttcacttg aaaaacacct cctaagtaga cactgataaa 49680
ttgattttaa tccctatttg agcaccaatg caatacatta ctatttcaag atggagcatt 49740
agataactaa aggaaattct attgtgggct tgtaaatatc atgatagtca tacctatgta 49800
atacatatat gtatatataa atattaattt ttaaacattt acttagctat taaaaatcaa 49860
atgctcatat ttaaaattat tggtttatta atgcaccatc acatgttatc atgtgatact 49920
ctgaattctc tttttgcata gacaaatcag agattacctg ctgcaagtca ttagtcatca 49980
ttaacctgta ctgaaatggt tagagcctag gggagttcca ggtaaaagga ccagtaatga 50040
gtagaagctt gttagatgta gagatattga ggacagagat aggtgcttta taaatatcaa 50100
tttgatataa ttttagcata aaaataagcc tatgatgctc tttgagcttg ggagtagaag 50160
tggatatgta attttcaggg cgtagtataa aatggaaatg cacactcctt gtttgaaaat 50220
tattaacgat tttacaaggg tgacaacaga gcattgaagc aagtgctctg tgagcatgaa 50280
gccctgtgtg aaatacacac ctgtgaagct ggccttgcct gccaaacagg aatgctggta 50340
ctgttaatca aacagaaagt tcagaatgac aatctgactt ttttttgtag aagatactaa 50400
acttttggcc ttgaatatct gaatttaaga tactggtatc aagccaaaag aaatttgggc 50460
ttagaacttg aaagatttaa acttgtgctt tgacttgtgt gctcacagct ctctgtgtca 50520
caattttttt catctgtact tcgggacaac aatagtgtgt cgacatcaca aaggttttgg 50580
gaggattaag taggtgaata catatgaagt tcttaaaaga atgtctggca ctgagtgagt 50640
gctacctcgg ttttggcatc gttattgtgg tcattgctat tgttattatg acttgaagtc 50700
atattagtgt atgaaatccc atccatgaat agaagacaga aagaactttg ggcagggttt 50760
ggaggtaaaa gaagacattg taaaggagat gggtaaagga atgattttaa agactgagaa 50820
taattagggg agtacgatgt catggaaatt aagggatgat aagcaccaat taagttgtta 50880
ttggactttt ttctttgaat ggttcaaatt cagaataata aggaaagaag tctgattata 50940
cgaaattaaa gggtagggtg actgtggagg tagtgggagt tgacttttct gctaataagt 51000
ttagaaataa aggaaaaatg gtagcttgag gaaagagagg agcgattaag ggaaagtctc 51060
tcgttaactc ttgtttttca tctctgagga cagcgcttag cccaaggcct gacctgtgat 51120
cattactctc tcaaggttta ttccatggac agagctatct catttcatgc ttataacaac 51180
cctacattat tagaattgtt ttagagatga ggaagctgag acacacacca aaccagcctt 51240
ccaatttcac tttgcacaac tttgaatttc tttatatttc ttgaataaaa gttccacttt 51300
ttaacttacc acttcttagc agtcattgtc taactgagta attgttactt cattcattta 51360
atggttctca gattcgcata atttgaacct aaatttaatt ggcctccaag ctgatgtgct 51420
tacagaaaca gtgacaggaa acaaaaatgt caagggagac tatgtattat taagatgata 51480
aatgaaatga tgtccaagct gagcaattaa agtgtgaagt agaaggacac agggtgagaa 51540
actgatgctt ctcctcagcc tctataaaaa agatactgaa taaagataat tgagaggcat 51600
taggggacta gactgagaaa ggattggaaa tctgttcact gagagtacag aaatgaggaa 51660
gcttggaagg cagaagattt tggtcaaaga cgtctggctt gaagctattt cagctctttg 51720
gattatctgt ggtggaggcc atcacgtctt tggagtggag gtaccatgaa actagtgtct 51780
gcaaaacatc atctaaatga aagcaaaatt cctgagaagg atggcactat aatttttaaa 51840
agaaaagcta tgagttaagc attcatatca aggtagatgt ttggagtgta ttgcttgtgt 51900
gtgaaaaggc agagatgacc agaataagag ttagaggtat gctgcgtttt cttcttggtt 51960
gatgagtagg atggcctgga caaagaagtg acctctagta aaataccttc atagtgtcaa 52020
atcatctgga ggaaattcag attaaagagg ttggatgatg tcgtaattaa gatcctgggc 52080
ttttaaggtg gacacattta tattcaagtc ccaggcccaa tgcatattag ctctgttact 52140
tgagctttta tttctgcatc tttaaagttt ggcaaaccta ttacatgaag ctgttgaggg 52200
gataaatgaa ataacgcatg caaagcactt gcagtaaaga ctaattatca atattttatt 52260
tgttaagagg cagcattgcg ttttactggt caagtatgta gactctgggg tgaaacatat 52320
ttggtttggt ttcatctctg caatttatag tttgtgtaga ctttgagaat agttctcaat 52380
cattctaacc ctcagtgaat tcatcttcta atgggagtga tatcagtatg gatttcatga 52440
gattatgaaa agaaaatgcc tacaaagtat ttattacaat gcctggcaca gaacaagctc 52500
tccttaattg taaaaatgct aactcttatt cttcataata aataaaagta attaatgtta 52560
tagaaaacaa aatcaaggat actgatttat atttggatta cttgatttat attttgtcag 52620
tctataactg gtcttaacta aggtaagtat taagatctca tttttaacag cgagtattct 52680
tttgatttta gttcattgga aatcctggga ttcagaaatg tggattaaaa gtaatttctt 52740
ctattgtaca ttttcctgat gcattagaga tgttatccct ggaaggtgct atggattcag 52800
tgcttcacac actgcagatg tatccagatg accaaggtca gtacaatttg aattcaggat 52860
ttagaataga tttttgtagg gcattagctg gtgactggat gtctttaaat atttttcttc 52920
agttttgaga tttaaaacaa ttcttttttt ttattttcct agaaattcag tgtctgggtt 52980
taagtcttat aggatacttg attacaaaga agaatgtgtt cataggaact ggacatctgc 53040
tggcaaaaat tctggtttcc agcttatacc gatttaagga tgttgctgaa atacagacta 53100
aagtatgtgc attatcttgg aaagaatttg ggaacttgtg cgaatttcac ttttggagca 53160
gtttgtgtaa ttcccacttt gcatgaatgg ggtattctag ttaatggaaa accatttatc 53220
cttttgtagt attttaatta tacaagcaaa gaaaattgga ttgaatctct aaagatccag 53280
tgtttcatta tgaaatctct aaagtcagca tggttattca ccatttatct tgcccataaa 53340
agttcagaga atgtgctaag aaatcccagc tagctgagtt tattcgctta gattttagat 53400
aaatagaatt tataaatatt ccaaagtttg tcactctctg ggttttattg caggttgctt 53460
acctttagta attttgcttg ttgatttttt tccttgcagt gaaaaaatgt ttttaacatt 53520
tttcatcaag caaaatttaa aacatgatat ataataactg tctttgtaag gaattcaaga 53580
tactggccta gagttagttc acgggagatt aagaataaat ttgttttgtt ttgtttttta 53640
attgtagcaa aacaaatagt ttttcttcaa gagtttctgc cttggttgtg gagtttgcaa 53700
ctttcataaa ctacaaagga attttttttt tttttttgga gacagggtct cactctgtca 53760
cccaggctgg agtgtagtgg cagatttcag ctcactacaa cagctgcttc ccgagctcaa 53820
gtgattctct tgcctcagcc tcctgagtag ctcagactac aggcatgcac tcccatgcct 53880
ggctaatttt tgtatttttt gtagagatga ggtttcacca tatttcccag gctggtctca 53940
aactccctgg tctcaagcaa tctgtcctgc tcagcctccc aaagtgctgg gattacaggt 54000
gtgagccaag gtgcccagct gactcaggaa atattttttg taactggcag cattgaccag 54060
gaataaaaat acctggtctc taatctttgc acagacatta tcagtaaatg agagaatatg 54120
tgtaaagttt tttaaaaaat tataaagtta tgaacataca aaattcttag attaataaca 54180
acaatgtgtt ttataactgc ttttcataat gtgcctcagg ctaggctgat taaaccaaga 54240
taggattgat taaaagtaat cttagggaaa gggaaggatt ttgtgccggt atggaactct 54300
cagttactct ggattaattc atctaggcat aaattttaga atctctatag tagagtttat 54360
gaactaaatc tggcctgcca acatatttta tttgtccagt tcagggtttt gctttgtttt 54420
ttgagacaga gtctcactct gttgcccagg ctgtagtgca gtggcgcagt ctcagctcac 54480
atcaccctcc gcctcctggg ttcaagcaat tctcctgcct cagcctccct agtagctagg 54540
actacaagta tgcaccacca tgctcagcta atgtttgtat ttttagctga gatggggttt 54600
cgccgtgttg gccaggctgg tctcaaactc ctgacctcaa gtgattcact cacctcggac 54660
tcccaaagtg ttgggattac aggcatgagc cactgcaccc ggccttcagt tcagtgttta 54720
aaagttttta attcgaatga cgtactttct gcacatttgc atggcctgct ctgctgtagc 54780
attcacttgt tttcagagac ctctgctcta gaggcaggtg gatcacctgt ccctcagaca 54840
tacataaatt aaggctactt tgcttatcaa atattagtat tcgtagatac tcagcatcat 54900
aagagttcga agtaataatt ttaatattta gatgacgtaa gttaatttaa aatttttttg 54960
agatggggtc tcactctatg gcccaggcta gagtgcagtg gcacaatctc ggttcactgc 55020
aacctctgcc tcctgggccc atcctcctgg gtgggctcaa gtgatccacc tcagcctcct 55080
gagtagctgg gactacaggt gcatgcacgg gtaattttaa aatatttttt ataggcacaa 55140
gattttgcca tattgtgcag gctggtcttg aattcctggg ctcaagcaat cccacagtgc 55200
tgagattaca ggtgtgagcc atggtgtcta gccaatttta ttaatatgta atattagagg 55260
taataaaaca ttaaaaagtt aagatgatcc ttggtggctt tacccaacct aaataatact 55320
aaagtcaaaa gcccaatctt tcattaaaac atcacatgag tgaagaggac agactctggg 55380
gatgtgctta aggtggttct aaaaaagtaa cggtgttctt tataaataac ttattattag 55440
aatgtaatcc tcagagtgcc ctcagcgctt ctcaactaca ctcaacataa atgaaatcta 55500
ggagtccaca ctagcctttc tgagataaac atttcggaag acagcgcaaa aagctggggg 55560
atatgctagg ctctctagag aacctactgt tcaatattat aatacaaatt tttactctat 55620
tgacctgttt ggatgtgtag ttctgctgat ccaaccgctt taatcctgtt taatatctgg 55680
gtttcatcct ataactatgg ctttagacaa gcatctttga aaaccaaatt tgagggtatt 55740
agttcttttt cctgctttgc tactgaatgg tttgttaact agcattttat tctctgtgcc 55800
tgctatattt cttagtcatg agagagagag ggagtattta tttacaggat aaatacttta 55860
aagcaccaac ccaatatatc tatagttaaa tgaacatcct aggtattgtt tcatatacaa 55920
actctctctg ctttatactg tttattcatt ttgcctgtaa ttgcttattt tattattttt 55980
tttcttatac ttttagggat ttcagacaat cttagcaatc ctcaaattgt cagcatcttt 56040
ttctaagctg ctggtgcatc attcatttga cttagtaata ttccatcaaa tgtcttccaa 56100
tatcatggaa caaaaggatc aacaggtaca gtgtttttca cttgcatcct aaatgttatg 56160
tatttatctg actctaattc tcatttccac tctttttagt ttctaaacct ctgttgcaag 56220
tgttttgcaa aagtagctat ggatgattac ttaaaaaatg tgatgctaga gagagcgtgt 56280
gatcagaata acagcatcat ggttgaatgc ttgcttctat tgggagcaga tgccaatcaa 56340
gcaaaggagg gatcttcttt aatttgtcag gtaaatattc aaggcctcac ttttgtcttt 56400
gctcagtatt cttatagaat gtaagagccc tgccattgtg tatctcttac ttatatcata 56460
ttattcttca ctacagaaat ttaccagttt attgcaattg tttgtgtctt gtagtagatt 56520
tatagaattc cagaagtaat agggtccttt aggtgttatc cagtctaatc tttcatttca 56580
tctgtttact tatcttgtta agttgataaa taacttttca aatgtgtccc ttagtaggca 56640
tctctacaac ttagtctcca gatacactcc acataacaca tagttctaat gttttgataa 56700
ttttttaacc atttttttcc atggttttag tttctttgcc tagaaagttc tcccctgagg 56760
gctaccacac atggctatgc aggctgtgga tggcacactt ttgtcggtgc cattcacagt 56820
gacatgagtt gctgttggcc aaagttgtgt aacactggtc tttctttcct tctctcttcc 56880
ctcctgaacc atgtaaacat atatctatct gattgttctg ctctcccttc aaaatataat 56940
tcaaattatc tttctttaaa gccctcccca tacctccaaa cctccaaaca aaattaagat 57000
ttacttcttt tgtcagtcta tgaaaatata tacatatctc ttgtatactt ggtgagttgt 57060
gtgaaaataa cagtgtacag tgttcatctt tgtatcattc agaatatcga gctcattgct 57120
ttacatatgg tgtgtattca ataaatacta ggttcattgc ttatatttca gatttgtatt 57180
atttgtataa gtgttagagt ttatactagc attcaggtag cactatgtct attttctaga 57240
aatttaatat ttctaacaaa gcaattatgt agtgatttaa tacacattat taaataatca 57300
ataaagtact atgtttgcca atagtttact ttttaaacct tactgtattt aatatcccta 57360
ctgtatttaa tatcccactt gcctatggat tgaaatcaat ttgttgactg ttaagattaa 57420
gttaatacta attagtaatc aacataaaaa gaaaaagaat ttgtaaccca ttttcatgca 57480
ttacgtttat gaattaaaat cacataaaca atctaattat ttaaatttag tcaaatttct 57540
tttaagcaag caacaattaa aatagttgct ccgctttact aaagataatt aaatttttcc 57600
atcaataatt taatacattt ttactgtgca tcttttgcat gcagattatt gcattaattt 57660
taattgaaaa taccgaagaa ctaaaaagaa acttcccctt ctaagtccac attaaggaaa 57720
caacatacct aaaagcacct gatacaactg tactacattc cccacaggaa atcatttcta 57780
ctattctttc aatttatcca aatctttcta cccaacagga tttttacttt attcctcttt 57840
ccatattctt ttggacttca tatgcttagt tttatctttt ctttttaaaa cgaaatctta 57900
aatccaagga ttatgtatta ggtttaaaga atttatccca gttgtcagag gttatttata 57960
tctagcaaac aataactgct gattaaatct tgtggatgag tttgtcgtat gtaccttatt 58020
tgtgccagag caaaataagg taatcaggac tatttattca tttaccaaga ggttacatat 58080
tgaaggacta tctagagcaa gggtggagtt gtgttagact ttctgcagag aatttgataa 58140
tggaatgtac atgattggta gagaagaata tggaagttta atactgggta tgcaaatgca 58200
tggataaaaa cctcaaggta aaactcatca aatcacagtg gaaaaagtat agtgaagtct 58260
gaataaaaat aataagaggc tgggcatggt ggctcacatc tgtaatccca acactttggg 58320
atgttgaggt gggaggatca cttgagccag gagttcgaga ccaacttgag aaacatagtg 58380
agactccatt tctacaaaac aaaccaacaa gcaaaaaacc atgtatgatg gcacacacat 58440
gtagtcctag cttcatgcag ggtggctcat gcctgtaatc ccagggcttt gggaagtcaa 58500
ggcgggagga tcatttgagc ccaggagttc aagaccagcc tgggcaacat agttagaccc 58560
ccatgtctac aaaaagtcaa aaaattagct gggtatggtg gtacctgctt atagtcccag 58620
ctacttggga gtctgaggtg ggaggatgac ttgagcctgg gaggttgagg ctgcagttag 58680
ctgagattgc accattgcac tccagcctag gcaacagagc cagaccctgt taaaataaaa 58740
taaaataaaa taaaataaaa taaaataaaa taatataata aggctgaggt gggaggatca 58800
cttgagccta ggaggtcaag gctgcaggag ctaagattgt gccactgtac agcagccttg 58860
gtgacagagg gagactctgt ctcaaaacca accggtcggg tgcggtggct cacgcctgta 58920
atcccagcac tttgggaggc cgaggtgggt ggatcatgag gtcaggagat cgagaccatc 58980
ctggctaacc cggtgaaacc ttgtttctac taaaaaaata caaaaaatta gccaggcgtg 59040
gtggcaggtg cctgtagtcc cagctacttg ggaggctgag gcaggagaat ggcgtgaacc 59100
tggaaggcgg agcttgcagt gagcctagat cgcgccactg cactgcagcc tgggcgacag 59160
agtgagactc cgtctcaaaa aaaaaaaaaa caaaaaacga accaaccaac caaccaacaa 59220
aacaaacaaa caaaaaacca acaaaaccaa acacttctat catgctcatt accacctggg 59280
cactgctcca aatactttac acaatttaat ccttacgaca acctacgaaa aggtccagta 59340
ggttctaatg ttattcccat tgtgcaagtg agaagctgag gcactgaggg tttaaataac 59400
ttgcctaaga acaagctcct ggtaacagtg tgaaatctgc ctccacagtg cctgctttaa 59460
tttcttggct acacagcaga ttcatggtag tggtggtagt ggtgttcatt ttctctaaaa 59520
taacagtttg aataatttgg ttttgataat gcactgcatt tattataaat tagatgatca 59580
gagaaagatt gcagggataa gaaattatgc ttttgataat ctttagttat attcttaatt 59640
ttcttcatta ttatttaaat gtaaaaataa atatctgtga gcagtagtat tttcctgtca 59700
tgaagctgaa attactttca taaatatgtg tgaatattct aaagagaatg actctgtagg 59760
atttaaagaa attaattctt atttttgctg gcatttattt attttatcag attcactttc 59820
tcatatatgt ctctcttcat ggcaccatat gcctaaagtc agcttggata gtttggatcc 59880
tccaaggaaa attccttcca caaacatgtg cagcacacag tgctagataa ttaatagaga 59940
atataaaatg ggtttcctgt ttcaagatgg tttgtaggtc tgtatgtgta gggcattgac 60000
aagagagtaa aacataaatc accttagtac aaagtaagga gtgaatggca tatcttagag 60060
aaaaaaaagt tactgggcta taagagaagg catttgtgag tttttccctc cctccccgct 60120
tcccttccct tcccttccct tcccttccct tcccttccct tcccttccct tcccttccct 60180
tcccttccct tcccttctct tccctcccct ccccttctct tccctcccct cccctcccct 60240
cccctcccct cccttctcct ttctcttccc cttccccttc ctcttcccct tccccttctc 60300
cttccttcct tccttccttc ctcttccacc tgccttcctt ttaattttgc tatgagccct 60360
taaagaggat tttagtaatt tgctacttaa attaaatata tttgctagat gttgtgctag 60420
gcttcaggaa tacaagttgg attgcagtaa tgtaaagccc tttgcattct agcaagaaaa 60480
cagatgggta tgtatgtttg ctcagtgcta cattaaatga aatggatggg agccgggagg 60540
agaaatggtg tgtttggcct gagaggttag tagcaaggac ttctctgcaa gaaagtttga 60600
agccaattct tcaagaatga acaccttttt gctgggtgaa aagtagagga aggcatttgg 60660
ggtaatagaa atagcataaa aggtaatgag gtttgaaaaa ttacatgctg tgtttggaag 60720
aatgtcctgg agcagcagcg ttttagaagg tttttaaaga cgatggtgac ttgatcagag 60780
ctctgtagtg ctttgaggat gggttgaagg tgggcgtact tggagactgg tgggcattta 60840
attggtgcct tccaaccaca taaatgaatg tcccctcaaa tcccttggaa acactttaat 60900
tctagaaaat tcaaaaattg tccccaacat ctttttcctc tgagttggta ccctggatct 60960
ttgggtcttc ttttctttcc ttttttgatg ttttattttg ggtaatgaaa gtcacacagg 61020
ttttgaagcc agcagatttg gcttcaaatc caagtctcag ttgcttgcta gctgtaaggg 61080
acaaattata tatcttttct aaatactcat ctataaaatg ggagtaataa ttgctatggc 61140
ataggatttt tttaaaaaaa agattagaaa tcatgtgtgt acagaattta gcacagtaac 61200
tgatggatat tatttctatt acctgttatc ttggtcttct agttgatagc tccttgctag 61260
cgtctagctc ctttccatag ctcttcctga gtagggccag catgcagtgc cacagcttgc 61320
taaggcttct cctggattgc tgagttgttc tagtttttgt ggcacctcac atgctaaccc 61380
accctgaaca catgctctga aaacataaca tttagaggaa ggttgaagac tgagagacaa 61440
ggtatatctt tgaggaaatt cagatgcttg tcttgaggag ctcaggaaag ctagacacga 61500
gtaatgactg tcgtttgtgt gtggcattaa taaattttac aatagctatg tccccattta 61560
gttattctat gtcacaaata aaggcaggac agtagtattt actgtgttaa ggtactggtt 61620
tcccaggtat cttacagtga gaagacagaa gctcagaaag tgtaagcaat gtgcatattt 61680
ggtggagtct ggatgtaaac agagatcttg atgccaagcc tgtggagctt tgtctccata 61740
taatgttgtc tctttcataa taactgactg tcatgtggca gattattcat gctattctga 61800
cattgatggc attaatatca tcttattttc ccaatctatt caaggatcag ttttgcctta 61860
ttttattttg tttcattcca aattggagat gtagagaaaa atcacatgaa gtttgatttg 61920
ccagtctcct aaaaggaaga aaaatgtaga tttttaatat acttaatttt ttttctttaa 61980
taggtatgtg agaaagagag cagtcccaaa ttggtggaac tcttactgaa tagtggatct 62040
cgtgaacaag atgtacgaaa agcgttgacg ataagcattg ggaaaggtga cagccagatc 62100
atcagcttgc tcttaaggag gctggccctg gatgtggcca acaatagcat ttgccttgga 62160
ggattttgta taggaaaagt tgaaccttct tggcttggtc ctttatttcc agataagact 62220
tctaatttaa ggaaacaaac aagtaagtaa caaggagaat attttttaca attcttattt 62280
ttaatagtat ttttttaagt cactagtctt ttagtggtta ttcatgccag tttgagggac 62340
cttaagccaa agatattgca aaggtttgga tttttttttt ttttggctat gaaatacttc 62400
aaaatgacat ttaagttctt tatgagatag caaatagtta tttataaaaa tagagcaaaa 62460
tagtggaagc tttttgaagg ggtacttttt aatatatatt ttttattatt aaagtaagat 62520
atccctgttt ttaaaggaaa tataaaatta taaaaaagaa aataaaaata acttatttta 62580
tctcttataa gtaattaata tggatatttt tcctaacttt ttatatgctt acatgtacct 62640
atgcattcaa atgtatgtaa aagcatacac acatatttat ttggcatttt taacttagaa 62700
tatactttat atttcaattg ataatgcatt ttctttatac tttcaagctc atgtgtattt 62760
tgtacatatt atgtgtattg atggtaagtt accatcttct gacactattt ttatcttttg 62820
agctctctca tttgttcaca ctaaatgtgt ttttagcgtg aaagctccca gctttccctg 62880
tgttaactta gtcccatgcc catctccttc cccatggtca tcaaactcca tgaatcaaca 62940
ccttaaggac catcttgcaa gtaacatgtt tgcttctctc atttttatga tgcactcact 63000
agcaaaacac cagttttggt cagtctacca gtctactttt tccctcagtt tcaccaagaa 63060
aactgagtgc tgctagagaa aagtacccat ccatgcaatt tggtgccttt atacatcaag 63120
gtttccaacc gctcagtagg ctccaaaagt tccaatcagg ctgaattttc ctcggtttct 63180
caaacacttc gtgtaccctt acttccagtc tttttccagt gttactctct ctctacctag 63240
ctctaaattc tctcttcacc tggctgtctc ttcattcttc ctgtctcagt gctatcacca 63300
gtctggaagg ttctcttaca tgaccctata gcactttatt tctcacatat actaccattc 63360
accacattat ataatttaat ttttcatttt tataatctac tttttggtaa attgttagta 63420
ccatgaagtc aatgtcaatt ttgttcatgg ttgtaacctt accattgata ctagtgtttt 63480
gcacatagta gattatcatt tagaattaag tattcaatat tggcaaaaaa taaaaattgt 63540
gtaatacatt atgttgataa gcatgtgtgg aaacatgctt catatattga tatgaattta 63600
aattgtcctc ttttgaggac aatttggcaa tatctactaa tatttttaat atatgtacat 63660
acttttttga cctcacaatg tactgttagg aatctatgat acagacattc tcaatgtgca 63720
caaaaattat gtacaaaaat gcacattaaa acattgttta taatagcaaa agagtaggaa 63780
aaaaacctaa gtattcccca aaaggaacta ttcaaataaa taatggtaca tacatgttgt 63840
ggaatgcttt gcaatcattg aggaaaaaaa aacgtggagc aaatttaatg tcctgataaa 63900
gattacatta ctccgtggca aaaaaaaggg cacagacagt gtttttacta tgctaatgtt 63960
gatgaaaatg caactggaat atgatagtta taaaagtttg aatatgaaat aaaaccctcc 64020
agaaatgggt tccctggttg tctctgggtc tttggaaatt actgagacat ggttagatcc 64080
catgtttcat tacttaaact agtcttatgc caaaaacctg cttactttaa tcttcaatat 64140
ccgatggaga ggaattgtgg gcccattgga gagggacaga gggagattta tcattcacta 64200
tattctcttt gttctgtctg gagtttttac cattgacaca tcttacccag ttaaaaaaac 64260
atagaattgt catttgatta attggagggt ataaccatga tttcactggc agctggtctg 64320
agtaaagaac actttgggtc atagctttca aacatttttc aggtagtatt tgcctaagtg 64380
acatatttgt gtgtgagctc atcctaccgg gcttcgggat aatttcccat atcataacat 64440
attactctgg aaaaaggaac catttgggta tatgggtata gtgtaagcca tagtatcagt 64500
tgccttcttg gggtttatca tatgggtcca ccacatattt acagtaggaa tagatgtaga 64560
tacatgagca tacttcactc tgctactata attattgcta ttcctactgt tgtcaaagtc 64620
ttttagctga ttatctacac ttcacagggg taatatcaaa tgatccccca ccatgctctg 64680
agccccaggg tttattttcc tttttacagt aggaggccta accagcattg tattagccaa 64740
ctcatcactg gatattgtac tacatgatac agcagtatca tgtagtaata tttgaagtca 64800
ttacagtagt aatatttgaa gaaatcttcc tggctgtatg tagaacaatg aggactcagc 64860
caacttattc ttcatagtag agctaataca taatgtaatg aagttgtgag aagaatgtta 64920
actttgaaat tccatcaggt ttcccaatag tcataatgaa tcactcagca aactttataa 64980
aaataacaag atcctttatt tagcagttta tgtgttctat gcattgtgct aaacatttta 65040
tatgcatcat ttcaattact ctttttcatc accatatact gtatttatta tcatcttcat 65100
tttccaggtg aggacactga tacccaggga gctcatataa ctcacaaatg gcatttctat 65160
gacttgaaca caggcctgtc tggcttcaaa gcctaggcct tttcctgaat aaagttagtt 65220
ccatagagat tcagttttgc tgtctacatg aaagcattgt gtacatggtt atgttttttt 65280
aaaaaatata tgatctgcca cctgttaatt attcaggatc actagtgtaa ggtgactttg 65340
aaaggaaaaa tagaaatatt ctccagaagc atagcaatac gtaagaactt tggtcctatg 65400
tatgtttatt tttgcataat tgttgatttc taagttgctg gtgtatctct tattttcaga 65460
tatagcatct acactagcaa gaatggtgat cagatatcag atgaaaagtg ctgtggaaga 65520
aggaacagcc tcaggcagcg atggaaattt ttctgaagat gtgctgtcta aatttgatga 65580
atggaccttt attcctgact cttctatgga cagtgtgttt gctcaaagtg atgacctgga 65640
tagtgaaggt atttattata aaaaaaaacc ctttatgctt tatatttaca cactgacatt 65700
gaacaatagg acccaagaca aaaacctgac ctaaatcatc tggaaaaact tgagtagaaa 65760
tgtgtttatt atcgcaaaca gttaagttta ctaattttgg ttaaagtgat gggtcaagga 65820
agtgtgtctc tgtgcttcta aatgttatac taattggtta atggttaata ttccaggaaa 65880
caaactctga ctagactgga acgagattcc acgctctgtc attgactaga tcctttcgtg 65940
gcttgtgtaa gccccttaac cttgttaaag gtagtaatgt cgactttgca gggttataca 66000
taataattag aaaaaatgta tgtaaaatgt ctgcaacaat gcttggcaaa caggaagcgc 66060
ttaataaaaa aggtttttat ctttactata gcttaaaaca atattaatat tttaatagct 66120
cacttgagat aactttttaa aaaattaata tggtgaaata tataatgaca atgattaggg 66180
ctgatgtatt tagcattagc agtttggtaa aaatggagtg aggggctttc ttattaatat 66240
agtatgattg aaaacactgg gtgatagaat aaggatattt gagagggcaa aaaatgagag 66300
ttgttccaaa atattgtgtc tcaagtcaaa ccatttttaa aaatcaagtg tagtgattta 66360
tatacatata taatttatat aaaataaaat gcattcactt taagtatata ttttcatgcg 66420
ctttgaaaat taacatattc atgtggtcat tgtcgctatt aagttatgca atattttcat 66480
tatccaaaaa agtttcttca tgcctcttca ctgaaaacat ccccttcccc tggcccccct 66540
gacccttagc aatcatttgc ttcctgacaa tgtagattaa tgttttctct agttttatat 66600
acataggatc atacagtgag tactcttttg tgtctgtttt ccaaaatgat tgtactatgt 66660
tctaccccca ccagcagtac atgagcattc tggttgctct acatccttgt cagtacttgg 66720
tattttcaag ttacttttag ctgttctagt ggaggtttaa ttcatttaga tgtaattttc 66780
atttccctga tgactaatta tgtagaggat gttttcatgt tcttattggc cattcttatt 66840
tttgtgtgaa gtgttgaagt attttgcttt taattgggtt gtcttattat ataagagttc 66900
tttgtatatt ctagatagaa gttgtgacag gtatatgtat tgcatatttt tttcccagtc 66960
atagcttgtc ttttcatttt actaattcta tttttaacaa aacagaggtt ttaaatcttg 67020
gtgaaatgca gttttccagt ttttttcttt tatggtttgt gctttttgta tcccacttaa 67080
gaaacctttt cttagcctaa atttgtgaat attttctccc atattttctc ttagaagtgt 67140
taaaatctca gctttggcat ttaggtctaa aacattttaa gttgattttt gtgtgtggtg 67200
tgtcaatgaa gagttgacat ttatttcttt ctgtatggat atccagttgt tccaacatta 67260
cttgttgaaa atattatata attcctcatt gaattaatgg aagctttgtt ctctttaatt 67320
gactatttag gtatggttct attttagcat tatttattct gtgccactga tttatacctt 67380
attcttatgc caataccaca ctgtcttgat tactctagct taatagcagt tcttgaaatc 67440
agatagtgta agtcctctgg tgttctttta aaaaaaattg ttcttattat tctaggttct 67500
ttgcatttcc atataaattt ttaatcaact aactttatgc tgggattttt attgtaatta 67560
agtccatatt tagattttat atagaattta tttataaatt aaatcatatt acctatgatt 67620
ttaatgtaat ctataatata taattaatac ataaataata atttatatag attatatcta 67680
taaattaatt tgagggaact aatatattaa taatgagtct tttgacatat taatgtgata 67740
tatagttcaa ttagtctttt aaaatttcta acagtgtgtt gtattggatg ttttctgata 67800
ctattataga tggtattgta tttgaattct aatttccagt agttcactgt tgatatatag 67860
aaacataatt catttatttg tacatgaatt ttgtatcctg taaacttact aagctcactt 67920
acgtgttcca gtaccttatt atagattcta caggattttc tttgttcaca attataccat 67980
ttggtaataa agacagattt gctttttctt ttctaatatt tatgtcttct ttttttttct 68040
tgtcctattg cactggctag gacctccagt actatgttga atagaattgg tcagactggg 68100
catcattccc tggtttccaa acttagagga aaaacataca gtctctaatc actaattatg 68160
acattatctg tagtttttca tagatgccct tcatcaaatt gaagaagctt cttcctagtc 68220
atttttggag agcctttttt tatcattaat aggtgttgaa aaatgctctt cagcatctgc 68280
tgaggtattc atatttttca cctttatttt gttaatatgg tcaaatacac tgactgattt 68340
tctaatgtta aaccaacttg cattcctgga gtaaatctca cttggttatg gtacattatc 68400
ctttttatat agtattaaat tttgttttct aaattttgtt aagaattttg catctgtgag 68460
agatattagt ctgtagtttt atacttcctt gtaattatgg gagtaatgct ggcctcttga 68520
aatgaattgg gaagtgtttc ccattccaca attttctgga agaatttgtg taaaggtatt 68580
ttcttcttaa atgtctgata gacttcacca gcaaaggcca tctaggtttt aaatttttgt 68640
gaggaggaga tttagaatta tgaatttaat aactttgata gatgtatgat tattttaatt 68700
ttcttttact tcttaagtca gttttagtaa tgtgtaactt tcaaggaata tgcccatttc 68760
atataagttg ccaaatttat ttgtttaatg ttacttatag caattattta attatcctgt 68820
tagtgattta attatcctgt taatctcttc aaagaatcag atttttgtta tattgatttt 68880
ctctattgtt tgtgttactt tctcacggac ttttgttctt atctttattg ttcccttttc 68940
cttacttatt tttattttaa ttgactcttt ttatagattc ttaatttgga agcttagaac 69000
actggttttt agaaccttct tattttgtaa cagaaacatt tatttaaggc tgtatatgtc 69060
cttataaata tcactttcac tgcatcccaa tattttgatg tgtcctcttt ctattcattt 69120
aaaaaaattt aatttcccaa atgtccaaca atgatagact ggattaagaa aatgtggcac 69180
atgtacacca tggaatacta tgcagccata aaaaatgatg agttcatgtc ctttgtaggg 69240
acatggatga agctggaaac catcgttctc agcaaactat tgcaaggaca aaaaaccaaa 69300
caccgcatgt tctcactcat aggtgggaat tgaacaatga gaacacttgg acacaggaag 69360
gggaacatca cacaccaggg cctgttgtgg ggtgggggga agggggaggg atagcattag 69420
gagatacacc taatgtaaat gaggagttaa tgggtgcagc acaccagcat ggcacatgta 69480
tacatatgta acaaacctgc atgttgtgca tgtgtaccct agaacttaaa gtataataaa 69540
atatatatat atatatataa atttaatttc ctttgtgact tctttgattc acgagttatt 69600
tagaaggctg tcatttattt tccaaatatt tggagatttt ctggataact ttctggttat 69660
tggtttcagt ttgacttttt tgtgctcaga taacctactc tgatgatttc tatcctttta 69720
tatttattga aacatgcttt atggattatc atatggtctg tcttggtgat gtgccatgtg 69780
caactgaaaa gaaagtatat tcagctgtta ttgggtcaaa tcaataggcc aaattgtttg 69840
gtaggatttc tcaagttttc tgtgacttca ctgacttttc tttctattta ttgtatttga 69900
tagagaaata ttgaagttgt aattgaggat ttgttggttg ccttttcagt tttatctgtt 69960
tatgctttgt atattttgaa gctctgttgt ttgttgtgca aacattaagg actatataac 70020
aaaggactat atataaaaat aattttttaa ataaagtaac cactttatat taatctaagt 70080
ttgcagttag tatcattttc ttcctctgga agaattccct tttacatttc tagcgcagat 70140
cttccagaaa cccatatgca gattactgga gcactttttc cataactgcc ccagaactcc 70200
cagctatctc agtctccata aatgttgatc tctatctcct catctcagga aagccatgag 70260
actgtttaaa tttcttctta tgtatatggc ccttaatttg tctctaagca gaaggccaga 70320
gtgatcatag ggctcacata atttgtttcc cttctttcgg gtattacata gtcctatgct 70380
gtctgttgcc cagtgtctgt atccagtcat ttaatatatt tatccagttt tcttgttgtt 70440
tatgtgagta ggttaagttc acatttgtta ctctatcatg cctgaaagaa ctctcttcaa 70500
gtatttttca agaaaacatt agaaatttta acataaaata attataaaat gcactatgct 70560
gcttgtacaa ataatgtgct aatagacatt tcacacacat ataaagtggg ataattatga 70620
taatttaata atctttataa ttatgtaatt gttactaaat tataaattat attttattaa 70680
aattcttaag cattaaaata atttaaacta tagaattaat taaactttag caatgaacca 70740
ggcaggaact gtttatatca ggatttatac tgaatattat aagggtggta tttggatata 70800
cagattttat aatttggttt tgacataaaa tgaattcttt ctttttctaa gataaagagt 70860
aggggaattt aaaatcataa ttaatttttc acaaatgcat tcacattatt tatctttaat 70920
atgatttttt tattgatctt tgttttcttg taaatttatt attttgaaag tactgccttt 70980
tccttatttt ataaaacaat tattgccagc caaatttatt gtgtttattt taataccatt 71040
ccataaaaga aaccatgaaa catgaaattc aaatagaaat ttattaaaaa ttgctgactg 71100
ttaaataatt tgtgtgatta caacatttaa agcaagattt gaaaaattta taagaaaaat 71160
tcagggagtt aatccactct ctttcctatg ctgctagacc ctattccagc ggtctccata 71220
aaaaaaattc agagaaacag aaagcagtaa cagtgatcag attgcataca aactttctgc 71280
acacacatat atttgttata acttatgtaa ccgttgattg atttggcttt ttcctgctgg 71340
actatgagct cctctgagga atagatttat tttttttctg catatcagta tcccgtgctt 71400
acccagtgtc tagtctgtaa cagccattct ataaatattt atgggtgaag aaaaatgttg 71460
ttgaattttt aaagtgaaaa accaacatgg cttatcatct ctattttaaa gattttacaa 71520
agggaatgga ctgtgaaatt tccattaata aaaataggtc taatcttcca tgattgaact 71580
atgatagaag gatcttatga ttgagtaagc tttttgtatt caccttcatg ttattttatc 71640
attttcaaaa taggaagtga aggctcattt cttgtgaaaa agaaatctaa ttcaattagt 71700
gtaggagaat tttaccgaga tgccgtatta cagcgttgct caccaaattt gcaaagacat 71760
tccaattcct tggtaagtta aattgtgcaa ttgtgattat gttgtgtttt gctgctgaca 71820
ttctcttgat aactaaaatt tatgccaaag ctaggaacaa ttggtaggga tttccctgat 71880
gtatgaaaac tataattttg agatttttat atatgtaata gatatgaaaa catattagat 71940
gtaaattatg ctcaattcac atttgtagtc ttttgagtat gcagggtatg aattttttgg 72000
ggcacatata tatatatata tatacttaca gtacacttca agatggtttt cttctttctt 72060
ttcagaactc catgtctgaa aagagcccag gctagacctc tacctaatgg tgtgggttgg 72120
tcccatgaac actttagcta gaaatctgat agtgatttct aagaaaccag acagaagtct 72180
gaaggacact gaacaagatg gagtagcata atataattca ttgttcatct atctatctat 72240
catctatcta tctatctatc tatctatcta tctatctatc tatctatcat ctatctatca 72300
atcatctatc tattttggtg tattgaaagt catttaattt tttagatacc tttattatta 72360
tttcaacctc ttgtctgttt tggaactatg gaaggactat ggcatatttg catgaggagt 72420
ctgataattc tagttgagga aattgggagc caccttattc tcaggttcac tttgaaagac 72480
ctgttctaac ctattctcca attttgatta tagctgagta ctaaaaatat gagggttgtt 72540
ttgtgttaat tctagatctt aagatgggtg aaatgaatga ctgtagttga atcggttaaa 72600
ttagctgtca gtctttatat gctctttcga atttatatat aaatttagtt ataaaaagta 72660
gtttggttaa tgagaaatta tatggatata gctttttcac tcaacctttc tgtttttcag 72720
tttccttata tttaaaacaa aggagaaaga gtagatgctt tctaaggtca tttgagcact 72780
gaactggagt tttcttttat cctcataatt gggttcttag tttttacttg cctatttttt 72840
cccataatta taaataccat taaccctatt aaaatttcat ggttccttcc ttataaaaat 72900
gtcctcttct ccaataaatg acagcaattt tattataaat tattttttaa taggggccca 72960
tttttgatca tgaagattta ctgaagcgaa aaagaaaaat attatcttca gatgattcac 73020
tcagtaagta tttggatgta atcataagta aatagatatt ttgggcagaa tgcagtgttt 73080
ggttgaattt cctccaatta ttcaaatatt cttggtgcca gtttcatctt acataatctt 73140
catatatatt tacctaatga ttccttccat aagctataga aaaatgaaac atacatttaa 73200
aaatttacct ttcttgaata ttatagaaca cattagtctt tttttttaca agttttctga 73260
aatgtaaata acacctccac caaggccact cttcatcctc tcctccagtt ttctttcttt 73320
cttttttttt tcacaccact tacaccacct gattaaatgc tttttattta ctgttcatct 73380
ctgccactgg aatgtaaact ccatagtttg gttttctact gaatcttcag tgccttgaag 73440
aaagcctgat tgctaggagg tgctcactaa acttttacta catgaattta aattatttgc 73500
ttatatttcc attgtttgtt tgtttttgac aaaagggtca tcaaaacttc aatcccatat 73560
gaggcattca gacagcattt cttctctggc ttctgagaga gaatatatta catcactaga 73620
cctttcagca aatgaactaa gagatattga tgccctaagc cagaaatgct gtataagtgt 73680
tcatttggag catcttgaaa agctggagct tcaccagaat gcactcacga gctttccaca 73740
acagctatgt gaagtaaatt taatttatcc ttgtaacttt caagacattt gaagagcttt 73800
tgtatttata tctaatttgc ataattaagt cgtttaaaag aacattctac ttttgtgtca 73860
ctgggtgata agtcccccgt gcctctggtt tttgcacaca tatcttagtc tgtgtgatgt 73920
tcaggagcat ctttgagggc aggcaatgga aacagatctg attagaaagg aattccaggt 73980
tctgtacgga gtacatgtta aagtctgtca agtgtatatt gattatactt taatcattta 74040
attcaagtaa gacaacttca acaatttaaa ttagattagg taaactagaa ttagacctgg 74100
tttggtagta ctggctctga ctcagctacc aactgtgtga caatatgaac atgtcactcc 74160
gcctgctcta atccttcatt ttctcatctg tgaaatagag attcaactaa atgattactg 74220
aaagtttttt tttcagttta aaataatgtg taacttaaag atttttttct ttttggtcaa 74280
agttcctgtc ttgtaagaat taaagtataa catagtttgt tgataggata gctctctgaa 74340
aattgacttt gctcaccatt tgtatgtact acagatcaaa atagttttga aagccaaaga 74400
agatatcata aaagttaaaa ttattttaat gcaaatgttt aaattgttaa attctcaagg 74460
ctgggcatgg tgactcatgc ctataatccc agcactttgg gaggctgagg cgggtggatc 74520
tttttgagtt caggagttca agaccagctt aagcatcagc aaaatcctgt ctctaccaaa 74580
aatatgaaaa attagccagg tgtggtgggg tgcacctgtg gtcccagcta cttgggatgc 74640
tgaggtggga ggattgcctg atcctgggag gcagaggttg cagtgagcca agatcgcacc 74700
actgtactct agcctgggca acagagtgag accctgtctc aaaaaaaaaa aagtcttgtt 74760
gcaaatgcat ttcccccttt ttaagcctaa aaaattaatc ataattttga gatgttttaa 74820
aggcaacatt acataaattt taagtatatt taagggatgt tttttctcta aagtttttat 74880
atctggagac agagagaaga aagaaaggtg acccactcct ccagccatgc cctaatgtct 74940
aaaatgtgtc tttctctctt ctccacttct ttgccttgct aaatacttca agccacccag 75000
ggctcaattt aactgtcact tcatcactct ctgcttctct tcctttttcc ttctaccctc 75060
cagccaacct acccacctag cctccatgtc cataacacct gatgctttcc acctaattct 75120
cattcggtca tccaatttga tttaaaatac ctttgccccc actagactgt gaactctttg 75180
aggacaggac ttgtttcagg cttgtttctg tctattccca gtgcctagtg agatctgaca 75240
tatggtagaa gtttagtact tactgaattg atttgtggag gaataaatgt ctgaaacttg 75300
gtaatccttc aattaatatt tgttaaatga gcaagcaaaa taattttggg atttagtcta 75360
gttaaaacaa agagaattgg aagagactgt gacaaggtga gacatgccgg cattcaatga 75420
ctggacaagc tcagaacctt ctcttaggga aatttcaaaa tgacaccatt agatggcact 75480
ttgtttgttt gtttgttatt gtcaaagggt ctcatctatg ttccttttat aggaacattt 75540
cctgattaaa ccttgggaat aattttaaaa tctttacttc agaataagtt aatgagggtc 75600
tgaaacaaaa gcaggaattt tgaaacaact tctggggcta agagtggtta ataagcctct 75660
ataatgatat caaactctag agtttctcgt gtggataaat atattgataa ataaagaaga 75720
ccatagagaa gtgattgatt ttggtatttt agctctttga gagtattacg tacctaagtt 75780
ttaaaaaatt gacataatgt gtaagtaggg gtttgctatt atcattataa aattagaaat 75840
tgcttaaaaa tagaaagtag aaatttgaaa caaaaagttt cgtaaaaaac aggaggttct 75900
aaaatgaaac acattataag taactatttt tatagttaaa tcttaaatat atcaaaatat 75960
gtaaaatttc tgacagcatt taaaacatat tcccaggatt atattgtact ttttgttaaa 76020
tcattaattc aaatatttgt tgaggcgtat tctgcttcca ttttgctctt tctggaaata 76080
atttacaaaa aagctgaagg aagctttcaa ctctattttt gtgaacctgc tttttacaat 76140
ctacctgttg taattttcct ggttttaccc atgctacaag cagagacgat tgggccaatt 76200
agtatactga aattctgttg tggattgtgt tttcaacttt ttgaaaattc ttgatggttc 76260
tagttaccag aggtgtgtaa ggcagaaata ttagctagac ttaagttcct cagatggttc 76320
actttagaat tttaaactat tgtcttttca gactctgaag agtttgacac atttggactt 76380
gcacagtaat aaatttacat catttccttc ttatttgttg aaaatgagtt gtattgctaa 76440
tcttgatgtc tctcgaaatg acattggacc ctcagtggtt ttagatccta cagtgaaatg 76500
tccaactctg aaacagttta acctgtcata taaccagctg tcttttgtac ctgagaacct 76560
cactgatgtg gtagagaaac tggagcagct cattttagaa gggtaagaaa gagctcatta 76620
aaaataaaag ggttgcctaa atatgctgat gttaacaaaa tatgctgaca tttttatagc 76680
aatgagtttt aacaacatgg tgaaactcca tctctactaa aaatacaaaa attagcccag 76740
cgtggtggtg cgcaccttat aatcccagct actcagaggc tgaggcatga gaatcgcttg 76800
aacccaggag gcggaggtcg cagtgagccg agatcgtgcc attgcactcc agcctgggtg 76860
acagaggcga gactctgtct caaagaaata tatatatata tatatataat atatgtatta 76920
taatatataa tacatatatt atatatattt attatatata atacctatat attatatata 76980
tactatatat aatacttatt atatatatac tatatataat acttattata tatataataa 77040
aagaccgagg caatgaatat tacaactttt atcaactgac ttacattttt acaactaatt 77100
tttaaattaa tgagtcctct ttgatgctgt tctttgaaag caaattgttt ttgatatttt 77160
ttctttaaag catatgaatt tatgcaattt aatcattatc ttgtctcttg tgactagaaa 77220
taaaatatca gggatatgct cccccttgag actgaaggaa ctgaagattt taaaccttag 77280
taagaaccac atttcatccc tatcagagaa ctttcttgag gcttgtccta aagtggagag 77340
tttcagtgcc agaatgaatt ttcttggtaa gtgttctgtg tgggtctcct ccttaccagg 77400
ccctctaagt tgtacaagat gagtcatata tggacccttt agttgtggat ttaaaagtgg 77460
catttcagtt taaatattat gctggattta aaaaataaaa ttagcaggtt ggcaataaaa 77520
caaaatgcta taaaactatg aaaagacatg aaagaaacat aaatgcatat tggtaagtga 77580
aagaagccaa tctgaaaagg ctacatacta ttcgttccca actataagac attctggaag 77640
agacaaaatt atgaggacat taaaaagatc aatggttgtc aggggttagg ggagggagag 77700
atgaatagat aaaggacaga ggatttttag ggcagtgaaa ctgttttgta tactatagag 77760
ggggatatgt gccatggtac acttgtcaaa acccatagaa tgtgcagtat aaagaatgaa 77820
ccctgatgta aactatggac tttgagtgat aatggtgtgt caaatattgg ctcattgatt 77880
ggaacaactg tgccaaacta atgcaaattg ttaataatag gggaaaatgt gtgtggggtg 77940
gtggtggtgg tgagggaaga agggatttat tgaaagtctc tggactgtgt gctcaatttt 78000
cctgtgtatc taaagctgcc ctaaaaatag tctataattt aaaaaaatta tcacattttt 78060
attgtcagag gttaaaatga tagttacttg gcctactgtg tagtaccctg tggttccctt 78120
tagtcttaaa ctaaacatgc acatggctgc ctgagctggg taaggcatcc tgatactgag 78180
atattgtttt tcatactgaa gtttcttcag caactttttg tatgataaat atgattactc 78240
tttgctgttg ttagaaataa aattaatcat ttaatggttt tcaaattagt gaagttaatg 78300
tatattcatt cagctcttgt gctttgcaag acattataat aatgcaaatt attatcatca 78360
cttttattaa aagttgtaga atcccctgcc ttctcttagc atatgaaata atagaggaaa 78420
ttatgttcat ttgtatccta aatgaacatt ttaattttaa ggaacaaaat acttttatga 78480
caataaacag gaattcccca tattttatct tccttcatag agaatactca catcttgcca 78540
cccatgtgtt tattctatac ctgactcagt aaaataattt ttaattctat ttaatagcag 78600
aatatggctt aactacttat taatagtatt ttaatttgtc agagctttca gaaactaata 78660
atgatcaaag ccatcttaat ttggatagta ttttcctcct tttccgcgcc ctcccttcct 78720
cctaccctcc tgaatattgg ccactttcca accatgatct tgaaactggg gatagagttg 78780
ttgactcact cactagtaag caaagcaaac tcggtctctg tccttaagga acttgtgatt 78840
aagttcagag cacagacaaa cattaagtaa tgatggcata aataaatgta attttatatt 78900
gtggtgcctt ctgtggaaaa gtttcaggat gctctgtggt acctcagggg aatctgattc 78960
agactgtgga gtcaggaaag catttctgtg cctgtgacat ttaagttggg tctggaaaga 79020
ggagcatcca aaaggacctt gaagcttgtg tatggtcagt gtgtcatctc agctgaatct 79080
cacaatgatc ctaatggtca tacctaggac aggtatgacc tctgcccaat tgaggaaatt 79140
gaagccgtga gattttttgt gtgatgctta caggtgcata caattaatta tcttgttgtg 79200
aaagtttgaa tggaccccag ttcaaaatct gtttgctttg cactacacaa tcttaatagt 79260
ttgagaagtg gtcttacatt tgagaagatg ccccatggag gtgacatctg agcaggacca 79320
ctaaccatta aaaaataatc ccatgtaaat ggtgaaaccc tgtctctact aaaaatacaa 79380
aaattagctg ggtgtggtgg cgtgtgacta taatcccagc tactcgggag gctgaggcag 79440
aagaatcgct tgaaccaggg agtcagaggt tgcagtgagt ggagatcagg ccacagcact 79500
ccagcctggc gacagagcaa gactccgtca atcaatcaat caaacaatca ataaatccca 79560
tgtaaaataa agttttagtt ctgtggcctt atgagtgttt tccatacagc atatgaaact 79620
caagactctg aagtcttaag tggagaatca tttcgattca tttattttgc gaataggtga 79680
ggtataatag ctatctttct gcttctcagg aagacagctt ctaggagtgt cctggaacat 79740
tttgaccctt gaagattgtc tagataaaga ataacccata tttttaacct tgaaaatgct 79800
aataactaat tcctcaatcc gttttcctag aaacggtaga tttgtagatc tctcaagtgt 79860
cttagtgttc atctgatcta gctacactct tttacagata agaaaagaga ctgtgtgatt 79920
ttctgtttcc caaattgtgt ttcacagaat tttatttctt ggaggtacct catactgcat 79980
ttccttctta acaattcata aagtaggcca ggcacggtgg ctcatgcctg taatcccagc 80040
actttgggag gccggggcgg gcagatcaca aggtcaggag atggagacca tcctggctaa 80100
catggtgaaa ccccatctct actaaaaata cagaaaatta gctggacatg atggcacctg 80160
cctgtaatcc cagctactca ggaggctgag gcaggagaat ctcttgaacc tgggaggcgg 80220
agattgcatt gagctgagat cacgctactg cactccagcc tgggcaacag agcgagactc 80280
tgtctcaaat aacaataata ataataaaat aataaaaaat aaaaaaatca taaaatatac 80340
cagagtattg agaactcaga tattttactt tattttactg aatgtttccc aatctcttaa 80400
gattatatga tcgaagaata cttttattaa ataacaccca ttattattcc atagaacact 80460
ctttatgagc tagtaccata aagaattttt gtccttataa tatactgtat tttagtaaag 80520
tgttcatagt tgttttgcta tagttattta agagtaattc tagttaatct atatggtata 80580
taataacatc acacataatt tgaaatgaat attctaggaa tttttacttt gtacaaatgt 80640
tgggtagaca aatttatatt taaatagctg tttagcttcc aggttaaaag gttctggtaa 80700
gtatagcata ttattttatt gtttagtgga agtattaagg ctattacctt atttttaaaa 80760
gtggattttt aaaaattgtc agtgtgagaa tggaaatcaa attaagtgac acactattgg 80820
tagctgttct tatttttgaa tttaatggaa atctggttaa aatgattaaa atgtttatct 80880
catttttttt cttttagctg ctatgccttt cttgcctcct tctatgacaa tcctaaaatt 80940
atctcagaac aaattttcct gtattccaga agcaatttta aatcttccac agtaagttta 81000
ttgttatttt aattttaaaa gcacattagc tggaacagaa cctttagaaa catgatttcg 81060
atttagtcat atagaggtaa ttgatttcta aacctactca acttgatgtt tttgtatgta 81120
tgaatgattt tcactagata aaagacccaa ctcattactt aaaatggaaa cttttatatt 81180
tatttagtgg atcattgtgt aaaaacaact taagattgtt taattaattg ctgtattagt 81240
ataatgaaat gagattatac tggctatcac tttaactttt aaaattttaa ttgtttgtgg 81300
aacttgatat gttgccaaaa tacccttaac tttcacatta tgcttaagtt atgtttgagt 81360
gaaattttgg gggaagatta ggcaagttta tgtagttcca ggtttttgag atattttggt 81420
taattcatga aaccagaagc ttcctgttaa ctttaaattc aggcattaat tggatcttga 81480
gtgtgttgta atcttaaatg ctattctaat tatatcatac atgataaacc aaattcataa 81540
aaatatatgt gtaaatttat cttttccttt gttttcttgc tgtcagctat tccttcaaac 81600
actatggctt tttagaattg acactaaaat gctgcttgca tgatgctgca atgagctctt 81660
ctgtgagctt atatttaggc aaataataat tagaatttag ccatagagag tgttacacaa 81720
acctataata gctaaattac gtctagcttt agaatgtgtt taactgttct aactactcta 81780
cagcggttca tctctttaat cttcctaata atgccctacg atagccactg ttattatctc 81840
cacttcataa gagatgaagt aacttgccca gagtcatagt tcttaaacac tggtggttca 81900
acttcaggct ctcaaatcac atgcatactc atatgtcaat aatgctagtt ttgacgttac 81960
actttattct caccctgggg aaaattattt gtgatgttat ttcatgtatt ttggaaatac 82020
tcatttggtt tatgtctttt ctgtgtattg ttttagcttg cggtctttag atatgagcag 82080
caatgatatt cagtacctac caggtcccgc acactggaaa tctttgaact taagggaact 82140
cttatttagc cataatcaga tcagcatctt ggacttgagt gaaaaagcat atttatggtc 82200
tagagtagag aaactgcatc tttctcacaa taaactgaaa gaggtaagac gattattgcc 82260
acttaaaaaa tatactttat gatttgcatc attacaaatt atcattttaa gtgatattta 82320
gcttctaaat accaatttca tgaaactaga agcttcctgt taactataaa ttcctgtcaa 82380
ctataaatcc agatttccat taaatttaaa aataagaaca gctactaatg atgtgtcact 82440
taatttaatt tccattctca caccgacaat ttaaaaaaat ctacttttaa aaataaggta 82500
gtagccttaa tacttccact aaacaataaa acaatatgct atacttatca gaacctttta 82560
atctgaaagc taaacagcta gatataaatt tgtctaccca acatttgtac aaagtaaaaa 82620
ttattagaat attcatttca aattatgtgt gatgttatca tataacatat tatagattaa 82680
ctcaaattat tcttaactgt tacttaacta tgacaaaaca acttagaacg ctttgctaat 82740
acacaagata gtataaggat aaaaattctt tatagtacta gctcataaag agtgttctat 82800
ggaatagtag tggatgtcat ttaataacta taaattcaaa ataagcattg taaatatcaa 82860
taccattcaa tttttttttg ttttttaaac aagttgtaag cctaccctat ggtaaatgga 82920
tatggtaaca cagcataatt tcctcaaaaa attacttttg tgatatactt ttaaaggatt 82980
atatgaatat atacataatt atagatgaat gtgatgctgt gtgtcattgt atcaccaaat 83040
ctctgtccaa tctgttaaca gactcttaaa taaaccattt ttctcaagtt gttactggcc 83100
tgtatactgt attacttgtt tttcagcttt ccttggtaca ttcttaaatt tctgcattcc 83160
gccaccatgc tatcacccta atggatcaac cttttttgtt ttgctccatt ctctctgttg 83220
taaatctgaa attgataatt tgtttgtctc agaaaatatt atttttcaag ttctagcgta 83280
ttgcctacaa aaaccaaaag aattaagtgt ctgacactgt gaggttcagc aaaactgtgc 83340
atatattttg ctacctgatt ttttgccagc aaatgagtgt tttctattat aaatatagta 83400
tatattgctt aaaaatttgg aacagaaaag aaattactcc aattaggatg ccacctaaag 83460
tataagcatg tagctgtact ttgagaacac taaattgcat gcaggtttgt agtgactagg 83520
tcttcttgcc tttactgaag gagcagaatg aagtcacaga taatggataa ccaaatccat 83580
tttgtggtaa gaacttcctt actttcaatg tcttgaagag atgaagtatg ttaccaaagg 83640
agattgggtt ttttaatatt acagatgagt gacatagatt gtttgggagt aagtttttat 83700
atgtaagttt ttatgttttt aaacacatac tgacaactta tgacaaacct ttggaaagtt 83760
ttaaaactct gttgaaaggt tgtgcaagct gctgatggaa tctgtgagcc tttcttgttt 83820
cttatcacgt tttttggcag agcacatttc ttccttccca ccaacaggtt ttgccctttt 83880
ttttcccatt aagattcctc ctgagattgg ctgtcttgaa aatctgacat ctctggatgt 83940
cagttacaac ttggaactaa gatcctttcc caatgaaatg gggaaattaa gcaaaatatg 84000
ggatcttcct ttggatgaac tgcatcttaa ctttgatttt aaacatatag gatgtaaagc 84060
caaagacatc ataaggttag ataatttttt tctatttggt tttactaaat ttatttcaga 84120
ttttctactc tctgtgactt tgatggacat atattgttac tatttaggga aaaataaata 84180
gtaatatttg gcattaatat gctgtgtgtc atttgccttt catttaatga atgtgtttct 84240
gtggtgccac tgtagagatt tctcattctt cttagccaga ctaatgttga gagcggcttc 84300
tcctccttct gtttcttttc agtggagtag actctaaaag aaaataagta ttgctatttg 84360
gtctctggtt accaattaca caatctaaag aaatacagca cagtataata acttctcaca 84420
ctgtatttca tatagcaact agttaacata tgcctcttac atcttaaagc attatagcta 84480
ctgacatcat gtgaaattac taacttctat tttgcccatt aggatgagta atctactcac 84540
cttgatcagt tttgaaagca ccaaaacttc tcaagtatca ctgtttctgg tctttacact 84600
ttaagcactt taaatatctt tggtaatgga ttttatcctc ctttttgttc cctttcagca 84660
catcggtctt attactttct cataaaatcc tttgctccct tttccacagt tactgtatta 84720
acgttgcaga cctcagctct gtcatcacct ctcaacttga ctgtaatatc caccaaggca 84780
gagaccatgg ctgtgttcac tcactattca aatcttggca cccaacacag tgcctggcat 84840
acaattaata gttgtttaat taccagtgat ttatacttac tcattctctt ctgcctaaaa 84900
tctcttaaat ttatatttaa cttcatctgt ttttatgagg aaggattttg ttttctgaac 84960
tcctgagctt gatttcattt taaaggagtt tgttatcttt tgtgctaatt gtggctaccc 85020
ttcatcctac ccaattattt ttctctcttg aaactggaaa agatggtcat ataaaaattg 85080
gttcagttct tactaaacat ttagtagaac tagctttcag tgtattatac tgtattatct 85140
aactaaatat ttttaatatt taatatttaa tttaatatat aactaaatat ttttaaacat 85200
gtttaacatt ttcagaaaag acagaaagac ctagagcaga ttagaaattg taggcatcat 85260
ttgctttttg aagaaagaca ttttttcaaa tagtggtgca ttcttaagaa ataaatcaag 85320
aaaggtaatg ttgctttttg gtcatatcat caggaatgtt ggtcagattc ttattagtta 85380
caggaatgaa ttgatcacta ctctgatgta aaattcactt atgatttagt ctttttctct 85440
aatttgaaac tgtggcaaca ttttaacata tttcaaaata tatctttctc tatccattat 85500
atttttgata acactttgac tctactatta gtttaaaggt ggttttttag ctacctaaac 85560
acttctattt cattcaggtt ttacattaag atcattagga atgaaagcta acatctgctg 85620
atagtataat agtttatatt tatttatgat gttatgtgat ctcactatcc atatatacta 85680
ttatatgcat atgtgatata catgaatata tagctataca tcatatatac catatatgaa 85740
tatatacaca cacatatata atgtaactaa tatgacccta ttatcaagct ttaacagtat 85800
acatatatct ctaccttgtt tctatgtcat atggactttg tgaaattttg aactttataa 85860
tttatagggt ttttcttttc ttttcttttc tttttttttt tttttttgag actgagtttc 85920
actcttgtca cccaggctgg agtgcagtgg cctgatcttg gctcactgca acctctgcct 85980
cttggcttca ggcgattctc ctgcctcaac ctcccaagta gctggaatta caggcacctg 86040
ccactgttcc cggctacttt ttggattttt aatagagacg gggtttcact atattggcca 86100
ggctggtctc aaactcctga cctcatgatc cgcccacctc ggcctcccaa aatgcaggga 86160
ttacaggtgc gagccaccgc acctggcgta taatttgtag ggtttttcat actatttaaa 86220
gacattagaa tatgtataca tgtatgtata tgtgtgtata tatagaggta tatatatatt 86280
gcatatcgta ttctaattag tattgcaaac atattttggc cttttgatta tttctggtga 86340
tagtgtaaca tgttttcttt ggtgatttta ccaaacatta tcaactaccc taaaatctct 86400
agcaaaatat atgcattaac agtactctga aagacatgta cattattagt tatatgagat 86460
atgcactctt ctggatacta tattttagaa tagtgtgaca tgtaaaagaa ctcacctaaa 86520
tctcaagtat acttttaagc agtttattat tttattttta tctttcaaat actaggtttc 86580
ttcaacagcg attaaaaaag gctgtgcctt ataaccgaat gaaacttatg attgtgggaa 86640
atactgggag tggtaaaacc accttattgc agcaattaat gaaaaccaag aaatcagatc 86700
ttggaatgca aagtgccaca gttggcatag atgtgaaaga ctggcctatc caaataagag 86760
acaaaagaaa gagagatctc gtcctaaatg tgtgggattt tgcaggtatt tctttctata 86820
gaattttaaa attcactttt accatttgtt tggaacaggg attcaaaaac tgagctttct 86880
gttctaatat ccagaaacct ggtagactgt atggaattat tccaaagccc ttcatttctc 86940
ctaattttac ccttgcctcc agaatggaga agaacatgga gggatatgtt aggaacaatt 87000
tggtgctagg tactttgatc ggttgctgac aaatatgcta aaagtggtca atcctagtaa 87060
aaacccagaa tagttctcta aacatggtct gttgtttttc tcttattagt atgctaaata 87120
ataaatagta ttattctccc agattttttt ttaaaaaagg attcttgcct gtcgtttgaa 87180
agattaaaaa aatttgtctc taatctttat ttaggtcgtg aggaattcta tagtactcat 87240
ccccatttta tgacgcagcg agcattgtac cttgctgtct atgacctcag caagggacag 87300
gctgaagttg atgccatgaa gccttggctc ttcaatataa aggtgatttg ttctgatcat 87360
ttgaaaatag aaaataattc atgtgtctgt gtgcgtgtgt gtgtgtgtgt gtaagttaat 87420
ttattttggg caaacaattg cttcagtctc tttaaatact ttcttaaaag aagcactaaa 87480
attttgaatt gggaaacttt ccgagtaatg aagtcataac atgaaaattg tatgttccat 87540
gttggtgaat gttattggta acctgaaact cttttatgct gtaaaacttg aaaatatata 87600
tgttcaactg ttttttaatt atattatttc ttaaatgaaa tctaaatttt tctaatttaa 87660
aataagctat attaaagaaa agcaatctat atatatatat ctcatcaact ttgtactcag 87720
gggccattta gtgtgaaatt cttcagattg tatcctttaa gtggtcccag attattatgc 87780
tgttacatct ggaatctccc ttttgttgct tttctatctt ttcctttgtt gtcttgttgt 87840
cagctattcc ttcaaacact atggcttttt agaatggaga ctaaactgct gcttgcatga 87900
tgctgcaatg aactcttctg tgcataaagt ccttaaaaag cttgtgtcag gacatttaac 87960
catgtaattg gctgcataca tgcttgtttt gtaatttggg tattttttaa tgtttctttt 88020
attaactttt ttacagctag ccaacgtgag caaatagtac agtggcagtc atatttgctt 88080
gagtggcttt tattctttca ttgtagactc caaattggtt gactttaaaa cgaatttaga 88140
agattaaatt cacagataag gaagagaaaa tataaactat atgacgttaa tttgatataa 88200
tttgtgggtt tatgaaatgc ttattttatt taggagtgaa taactcatct taaggcatga 88260
agatgggaaa ggaaaactat accactaccg ttatatatgc cacctaaaag ggtgaagaat 88320
tgggttaaga aaggccaaaa atgacttttt aaaatgtcgt aaggttacat ttttttctta 88380
ggtttaagga aaaaaggaca gttgttcttt tcttcttctg aagtctgcta gtttctcttt 88440
tccattcaag tgaatgtcac ggaaagcaaa tatcaacagg aatgtgagca ggcccagttt 88500
gaaagcaaac acaagagggt tttgtgtctt tccctccagg ctcgcgcttc ttcttcccct 88560
gtgattctcg ttggcacaca tttggatgtt tctgatgaga agcaacgcaa agcctgcatg 88620
agtaaaatca ccaaggaact cctgaataag cgagggttcc ctgccatacg agattaccac 88680
tttgtgaatg ccaccgagga atctgatgct ttggcaaaac ttcggaaaac catcataaac 88740
gagagcctta atttcaaggt aacatggtag gctggtagag aaatgtaatt tattgattct 88800
caactgccta gaaatgtcag aaattttgag aagtgagcaa ctcacttaaa attgtgggtt 88860
ttctttcctt gttgctgtta gcattattaa agtcctttcc attttaaaat tatttatgcc 88920
agacttcatt tctaattcat agaaatggga acaaaaaata attagaggaa cctgagagaa 88980
actaagagac cgtttctggg atactgagaa aatgtttctg agagagaatc tgagaaaatg 89040
tttttgatgc cttttctgat tcaacttctt atagtggtga ttcaatcaca agggtaaagg 89100
tgaatactga ggtcttggga tcatctttct tctattattc tttaactgtt atttttccat 89160
ttcctctttt cttttggaat tcctgtttta tggacatctt gatcttttgt gccactcatt 89220
catgaatttt gtcactgtga ttcccattcc aatttttttc cctccgtatt gtgaggcagc 89280
tgttttattt agtcatgaag accactaact tggttttcag cagtgtctca ctaattactt 89340
agttcataca aaatgggctt tttattttag gaattatgtt ttaaatgttt aaagttatct 89400
tctcgtaagc caaattttta taaaatgtaa ataaatcagt tatcagagag aacacttttt 89460
tttttaaata cttggcagaa aaaagaaatc ttcactgggt actacaggga gtgtggtgta 89520
aactgtactg aaaaataccc ttgatagttc catatgacaa acataatgat gaatttcact 89580
tagtctgtct tggcttagct caatagcact aatgatcaag atactggctg ataaatagag 89640
tcctatttgg cctgggcagt cccagcataa ttatgtaata gtgtcccact atattctcaa 89700
aagcattcca atttggatga taaattatat agtcaccttg gttataactc catgctggcc 89760
agttagctta gttctgttcc atttatatag attatgtgtg cttcactcca aaacctaatg 89820
agccatttgt aaaagtgatg gcttttgcgg tgcccaggga gagaatttgt atgtttgtat 89880
ccttcaacac acatttatta cagttattaa aaggttttat tgatgataga tggtaatgtc 89940
atgtaaaaat gacatattat ttatttgtag actttcctat tctcttgttg gacatgtaat 90000
tagaaactaa tatgacttaa agaaaaacaa atacacaaaa tttattcatc caattaatct 90060
cttaatccag gtgttttttt tttctgagac tatacccata cttcaataac tttgttgtta 90120
ctgagaatat tttgagtttc cctttttgtc attgttgtca gagaatgtat catatcttta 90180
aaaagacttg ttggaggatg agtttgtttt gaaaaggcct gaatttagtt gatgcaaagt 90240
cacagataag atggttcatt aagctgtatt aatactgctt ttgtctaata gatatcatta 90300
ccaataagtc agactagttt ttcttttggc acttataaat cacctttgaa gacaactttt 90360
tacaaggaaa taaaacaaat gctttgagaa ataccagtat tattgaaaga aaagtatata 90420
ttgctaatgg atgcagcatt ctggcataat ggtttgaaaa ctcatttgat tgctttgtag 90480
aagaatgact ctttcagatg acccagggcc tgtgagcctg ccagaacttg aaaattcttt 90540
cttccctgag gtgcttcaac ctgaattcaa agagcagctt ttaatctatt agagatcatt 90600
ttttgtcctc tcatttattt ttcatatttg cctttgatct tagctcttct ctaatctttt 90660
tctgtctcaa ccttattaac aggtgtctgt gcagacactt ttaagttttg ttttttggct 90720
cagcctgtca gttaactgat aatcatgctg aaaggagaag caggacaaaa cagagttcaa 90780
tgctgacaat actcctttta atcttgtcca gcccattagc agagcaggca tctctgtggg 90840
ccttgagacg tagtcccgta aaactcatcc cgtttctact tgatttgctt tctttgagaa 90900
ctcttgttta tttttatatg gaggtttcct gccttggatt aaaacataaa cctcaatctg 90960
aagttcaatt tcatcttaat ttatgaacga ctaagagagg gaacatgaaa agtggaggtt 91020
agtgaaatta tctctaattc tctgggttaa gagatacatg aaaacagtct cttgagtaac 91080
catttgcagg taaatatgga agtaatggtt atggttgtct ctttaagttt ttagtcacaa 91140
gtagaaaaag accaagttaa tttttttctg tgtgtgctga atttctattt gtagtaagtg 91200
taagaattta agcagaaatt ctgattcgta ttttcagata aaaagaatat gtaatttcca 91260
taggtccaga aatagggaga gtttgccatc tggtggttct taacggcact ctggatatta 91320
ttaagagttg catttctatt taaaattata ttttaaaaaa cgtttggaag atacttttat 91380
tgtagaaact atcctcttag ggccattctt taaaaaaatc ttattttata tatttctcat 91440
tttgttgata gtgattagat tctaagagca acagaacaat gatcatcctc tcctatcaga 91500
atcactgatg tttagatgat ttctcatttt cccaagttca aggttccatg aaaaacatag 91560
cttgagtggg attttatgtc tctgcgtttc actgttgata tatatgtcct cccaatataa 91620
cattttacaa ataaccaagc acaaaattta atattttacc ttgaatattt aaaatataat 91680
aatatccaaa agctcttgta atttgtactg atatcttata ctagcgtgtc tgtttcacat 91740
taagtttaat gtcttaggat ataaaaaatc ttttttatgg ttagtgattt atcttgtttt 91800
tttttccatg gaatttctgg atagcgagat aaatatttcc atactatttt atttgatatt 91860
tccaaatttg cctctgaatc aacaattttc ctattttaat ttcattgtac ttgttcctta 91920
caacctaaat agctttttat tatattttga ttttatttaa aaatgtactt ctgaataata 91980
tatctgtttc tgtaaaaact gttagcactg aatttgccaa ccatttgaca aatacacaaa 92040
taaaatagat ttttacggct tgtcatttgt aatttcatag atccgagatc agcttgttgt 92100
tggacagctg attccagact gctatgtaga acttgaaaaa atcattttat cggagcgtaa 92160
aaatgtgcca attgaatttc ccgtaattga ccggaaacga ttattacaac tagtgagaga 92220
aaatcagctg cagttagatg aaaatgagct tcctcacgca gttcactttc taaatgaatc 92280
aggtttgtgt ttttcgttcc ttattttcaa agctcagctg tagtaactta taaaagtgtt 92340
tctgaatctt ttatagaatt tacattcaaa gttgagagaa tatccatacg gttctttaat 92400
aggccactga tttttttctt tttggaagat catcatgtgt gttcatgaca aatcatgtat 92460
catgtcataa gaaaacaaat ttagaaatca cctaggagta aagcagtgga aagagtccct 92520
gagtgggagt taaaatattt gggttctaga acttgtcttt actattcagg agctgtggaa 92580
ccctgaatag tcaaatgaca ttcataatgt caaatgagtt tagtgcatgt gaaagttatt 92640
tttatattgc aaaggggaat tattgttggc atggtctaac tgggacgctt ggagagtcaa 92700
tggctccctg agatgatgca gcttctgagt ggaagatcta gctctcttgc atcaaatatt 92760
gatctcaaag atgaaaattc tcaaagcaac ttcagtgcta attgtgtact tgatcatatt 92820
accttgctag aaatgtgtga gttgtttgat agtactagag taagtgactg ggaagctgct 92880
tttgatccct agattctgtt gtataaaaaa tagcttcccg tggtttatga tctgttcctt 92940
ttccccatcg ttcttaaggt atgctgagat atgctgtgtt tcttatctgt atttgaaaat 93000
aaaacatgtc tttgtagtgt gtattcagca agcgaaacag aaaattatga atttctactt 93060
atgtgtgaaa tatgctctgt aatgcatgtc agtgtctcaa atatgcttaa atatgatcat 93120
tttatgtagt ttaaaaatac tccattataa tattggaact ttagaccata ggatgcacag 93180
cttctagtcc cagctctgtc actagctatg ctgaaatttc ttcacctgca aaatgaggaa 93240
gttggactag attttttcta aagccccttg atatttgttc tagattccat gtttcactgt 93300
ttgatgactt tttactacag gagtccttct tcattttcaa gacccagcac tgcagttaag 93360
tgacttgtac tttgtggaac ccaagtggct ttgtaaaatc atggcacagg ttggtgtctt 93420
ttatttttgt ggcacggggg ttatggtcaa agcatagaac agatggcgcc cagagcattg 93480
agcattttag aatttgggtt tagttaaggc agaaactttt gtgaatttgg aaaactgtgg 93540
aacatttcac atagaagact acttgaagag cttcatggaa gaaggaaaga tgtcttgagt 93600
tcacttccat gacttggttt tcaagccaca tacagatgtt tgtatcactc tgccccatgc 93660
tgctttacta gatcctgatg atgtcattgg tttggttact gaattagtca attgaatgat 93720
ggctttgtgg aaatccttgg ggtaaacaca tataagaaaa ttaggttgct gagcctgtga 93780
aacctctatc tagataacat ggaggtgagt tttgacttaa gtgaaatgat ctgagcttta 93840
aatgcttacg attttgaaaa ctttggatgg ccttggttat agctattttt ttcttatatt 93900
tcacatggaa aatgattttt ttctccaaat gataatccat taccaatgag tttaattagt 93960
tataataatc catctctgta gctttgacat aaaagaccat ttgagcaaaa catactacct 94020
cagggctttt caaccccagc atgatgacat tttgggccag ataattcttt gttgcacatt 94080
gtaggatgtt agcagcattt ttggccttta tattcgagac gtaagtagta tcctctagct 94140
gtgacaagca aaaatgtatc cagacattgc taaatattgc ttggagaatg tgaaaaatta 94200
ccctagttga gaaacattaa gctactgatt tgttgatgag taaaatttat agttttgcat 94260
gtggctgccc gagttcctaa aattattata tatttttatg ttagaaatat ctcttccaat 94320
taaaccataa aggtaattaa attcactcag gcagccttga ataattgttc ctaaattcca 94380
tctaaggaaa aaaaggaagc tattgtgaag agagaactca gttgaggcta aatcctgtac 94440
catggaactc aagagcatat tgaaacattg caatcagcaa ttatttgcag tgtgtcagtt 94500
attactattt tggtaggtat ttttaaatta gattttcagc cttctgcaca tatgtcatgg 94560
ataatgtgat tttactcaat tattaaatga taatggagac agtagtgtga cccagagcac 94620
ttacttgagc atcagcttga cctacgtttc agtctcttta attacttatt agctctgtga 94680
aatttcttaa tgcattaagc ctttgtttac ttacttttta aataaggaaa ataacaatta 94740
tcttctatat tgcctccctg gttcagtgta agtgaggggt aaatgttagc taattttata 94800
ttggatctat ttggcaattt aaagaatgtt aatcaggaaa ttttaaaaaa ttcagaacta 94860
taaagaggta cttacgtagt tttggaaagt gtgtcatgta tggggacaaa taaaaaagat 94920
gtgtaggtag ctgcatcctg tacagcaaag gaagttttaa atatatccag caattttgtt 94980
gtcctagctg gcgcacaata gttatcagga ggtaactcaa ctccacatag tcaaggaaaa 95040
gctaaagttg ctctctaaag tggtgtgttt ccatgtcact atggaacact tgaagttgca 95100
cacatgtgaa cattaggatg ggtatatctt atacagtaga ataaggaaga ggtttgcatc 95160
agaactcccc ttttaaaaaa atgcagattt tcactatgac tgcaataaaa ttcctgaaga 95220
ttctgtggag taattaagtt gaaactccat gaaagttctt ctcattagca tagttataaa 95280
tatgataatt taagtaaaaa ttaagttaat ttgagccact caaagttact tttaaagaca 95340
gatttaaaat gtcaataaaa tgataattta aatttccgat taacctaaaa aagaagtgcc 95400
atcattttta tttatgccaa taaattgaaa tataatgtca ttttatcact aaggtttaaa 95460
ggaaatgaaa tctctaaata atcaagtgaa accaagagca acttgtctga cagctattag 95520
caaaaataaa taggagtatt caccttcatg aatcaaggca agggccggaa taatttcatg 95580
gtgcagaagc tctaatgagc ccacccactc tatgcgcccc gagctgttag gtcactaaac 95640
ttattaaaaa aaggtaccat taaggcaggg agaagtttac aagactcatt taactgtatg 95700
ataaaagaga tatgaaagag acctattcaa ttaatcaggt ggaacattaa aaagcttaca 95760
tggcaattta accttgataa aaatacatgg gagaaataca aaggaatttg gaaaattctc 95820
tttccttgaa taaggcatca gttagctatt caggttatga ggttgaagga atgttaggag 95880
ctcttttaaa ggtgataaag tcaagataat gttgcagatt ttattcttat gtaacaaacc 95940
ccctcgaaac ttggaggctt aaaatgtgaa caatttatca tttctcgttc ttctgtggct 96000
tgactgggct cagctgcgtg gttctgctcc acatggtatt ggcaagggtt attcacttgg 96060
cttcattcat taaactgagc tggaaagtgc aagaaaggta catgcatgtt tttggagtat 96120
tggtgcttct ccatgtggcc tatcatatgg ctaagttggg cttcctcgtg gcacggtgat 96180
cacagaataa ttagacatct ttcatggtgg ctggttacca agagaaatga agcagatttt 96240
ttctgtcctc ttaaaggcta ggccaaggac tggcaaaaat attaattctg ctacattcta 96300
gtaaccagag caaccacaaa cctagctcag attaaagggg aaggaaaaga gactctatat 96360
gaatagcacc tatgtatagg gatggaaatg atgtgtccat ctttggaaac ttccactata 96420
aatagtggta gcacgctata gatccactag gaaaatcaag cacaaactct ttaaaaaata 96480
agtgtatctt agtaaaatag attagaataa ctagataata atggctaaca tacatgaggt 96540
taatatgtgc ttttcaaaga ttagctcatg taattctcac agcaaccttt ccaaatggta 96600
ctttattagc ccctatgata cagatgaaga aattgattga cagagaggtt gaataattta 96660
tccaacggta cacattcagg aagaggtaga gttagaattt caaaccaagt agtttgactc 96720
cagggcctat gagtttatac attcataggg ctgatattca aatgagagaa gagaagtaat 96780
aaataaacat ataatatgtt gagtggtaca gagtgctaca aagaaaatat gaagtgcagt 96840
tggagatgaa ttgtcaaaaa aggtcttagc acttaaaaaa cactaaaaca gcaaacaatt 96900
ctctttacca cctaaactgt aagagcgatc tggaattgct ataaagtaca caacatggga 96960
gaagtcttaa acaacagttt ttattattta taggcccatt gcacactgtc attaaatacc 97020
aatatgttca atcaaccatg cattcattga ttcaataaat actgtacata caaaatagaa 97080
atacagaaat gggtaagaca agtccttggg cctaaggact ttataacctg gtatttcact 97140
caactacatg atagcataaa taatgtttgc ttctgtttaa gtattcctta aacattatag 97200
atctcccaaa gaaaattaaa tacaaacctc tttttaaagt gaatttgaca aagcaaaata 97260
aattggaata tatagataaa tatgctaaaa tttgtcatat gtactttgcg tactttacat 97320
gtgttatttc attctcaggg caatctaaga cagtcacttt tattatctca ttttatagag 97380
aagaaagctg tgcagtaaag aaatcaaata cctttcccaa ggttacagag ctagtagtag 97440
agcctggatt tgaatctggg ttctgactga tttttaactg ccatgacaag gatcaaagct 97500
caaagtgtga tctctgtgtt agaaacatcg gggttgctct ttaaaaaagc cgattctcag 97560
gcctcaaccc agacctactg acccagacac tgcaagtaga atccatcaaa atgcagtagt 97620
tactttgaga atcatgaaac tctgctacac agtctgtctt cctattcatg gaagtcctct 97680
cctagtatat aaatgtgaag taatatttct atttcaaacc tgtattgata actgtctgga 97740
agataatttt cctgggaata tattattgat gagactgcaa aacagatgtg aggtattgga 97800
ttgatctttc cattgtagct agggaaatac tgatgttcat tgtttcagtg aagttcaatg 97860
atttcctatc cgaattaact cccttaattt aacaattttt tttttttttt tgagagtgaa 97920
tgcccctctg ggcttctagg ccacatggtt gctagagaaa ttaggtactg tgttgcactt 97980
gaaaacacta aaatctttct gactactttc actgagcaaa gagacataaa atgctttaaa 98040
tttgcaacat ttcagaaaat aaattttagt gattatttat gactcgaatc tttcagattt 98100
tgacagtgaa agtggaaggt tgtccaaaac accctaaggg cattatttcg cgtagagatg 98160
tggaaaaatt tctttcaaaa aaaaggaaat ttccaaagaa ctacatgtca cagtatttta 98220
agctcctaga aaaattccag attgctttgc caataggaga agaatatttg ctggttccaa 98280
gcaggtaaag aaaaccttaa aaaattaatt gctacatgga aattcactat ctattctttt 98340
aattgtcaaa ctaactgtag tctataatag atgtattaaa taaataaata tattttgctt 98400
ctagtgtaaa cctcctactg acatgtatca tttattttgg aataaaacat tgcatctgac 98460
actttaacaa tatagtaaat cacttacttt atgtgtatag ttactagttg gcttatcact 98520
gttgaaatta tttaagaaag gtaaatagtg gagattaatg tgtgtgtgtg tctgtgtttg 98580
tgtatgtgtg tgttcttaaa caacactgag agagtttatt aagcaagttc tgagaagata 98640
gtgagttttc aacagaattt taaaagcatt tatggcatca caatggatgc ctatgtttta 98700
gcctatacta tggaaatttt tcctactgct ctaagcaact gggaaattta taaagtaata 98760
tgatgttgaa atgtgcaaat tacattgatt gatggatgca gccaatttta aaaataaata 98820
tacacttttt ttctaggaca tgtatttttc aggatttata taagattaca tttgtctatg 98880
cataactaat tgtaataatt tatgtattag tgcacaggga ttaccgaaaa tatttcatgc 98940
atctacatct gagcatgcat ttgaattggt tattgaccac tgaatttttg gtgtaggaaa 99000
aatatgtagt gaaacaatgt tacaaaaaga ttacaattgt ttggaatgat taccttcatt 99060
gactttaagc agtaaaatca tttgctcaac aaggttgggt gttttgtgag gctgtataac 99120
catagtgtcc ttttgccttt agtttgtctg accacaggcc tgtgatagag cttccccatt 99180
gtgagaactc tgaaattatc atccgactat atgaaatgcc ttattttcca atgggatttt 99240
ggtcaagatt aatcaatcga ttacttgaga tttcacctta catgctttca gggagaggta 99300
agtatctaat gaagacttat tagattttta gagactatta atttagactt attaattttt 99360
agagaaatta gggagatggc atatgaaaag taatatgcca ttttctcaga gtttacttgt 99420
ttggaaggca gctgaagaat tagaaaataa gctcataaaa ccttggagta ggcaatctaa 99480
agacacacaa gcacatataa cctcatctaa tttgtcagga agaaaattcc ttaggtgctc 99540
actcagatct tgactgtgat tacattgtag ggactgtaat tatctctttt ctgttgcaca 99600
gccactaaga catttacaaa aaaagagcaa atccggtgtt tataatgcta actctttctt 99660
ctaaaataaa tagagacatt ttggtactcc aaagggaaaa tatcattttg gggattaaaa 99720
ttagctttac acaggtgtta ctggtttcca aaataaacct taccttgatt ggaattaatc 99780
aacatatagg tagttacatt gcattaaaaa gttcagaaag ttttgcgttt agcatgatca 99840
aaaacttctt tttaaaaatt atgaggattt atttatgatt ttctttcttc atctgtcgag 99900
catattaaac tgcttaacag catcaacctg aaatggatct taatgtgcag gggatttaac 99960
tctttttatt gtaaagttgt ggataaaata tttaatagat atggatgagg actcatatca 100020
gtaacaaccc aatactttat ttcaaaatga atagatctgt attacaatca cttgtgttgt 100080
gtgcagtaga ttttttccct ttaacttagg aagcagttaa taattaatgg ctccattttt 100140
tagaacgagc acttcgccca aacagaatgt attggcgaca aggcatttac ttaaattggt 100200
ctcctgaagc ttattgtctg gtaggatctg aagtcttaga caatcatcca gagagtttct 100260
taaaaattac agttccttct tgtagaaaag gtaaggaaat caatttgaat gttttcaatt 100320
gcaacactaa agaaatttaa acttaaaaaa aaaaaaaact ttaccttaaa gctttgcgac 100380
agtatgaggt ttagacaagg tgttgagctc tgttttgaat catgtaggct gtattctttt 100440
gggccaagtt gtggaccaca ttgattctct catggaagaa tggtttcctg ggttgctgga 100500
gattgatatt tgtggtgaag gagaaactct gttgaagaaa tgggcattat atagttttaa 100560
tgatggtgaa gaacatcaaa aaatcttact tgatgacttg atgaagaaag cagaggaagg 100620
tatgttttga tacaacttac aaatgctttt aagtgatcct tcaatactta tgaagtgact 100680
tttaataaat gtaaatattc ttatccataa gggatgagtt gaaaaatagt atattcaatt 100740
atagggacag ttcagaaaac tgaattatat ttattaccaa taaaatcttg tattctagat 100800
tcagaaaatg ttgatttgag ggtttgaatg ctggcttatt gagcaacata acctcatctg 100860
tgaaaccgga ataccaacca catctatctc atagaactgt tataaagatt caaatagaca 100920
atacatggac ctaatttacc aacatgtctg ccatataata acagctgcag cttcatgaat 100980
gtggcaaaag cagagagtag ataactttct agtcagatgt ctggtagtct gcagcagttc 101040
agaattctac aagtgaacgt aggaataagt ttttaaaatt ccaagtagat agatactaag 101100
tgaatcttta aaatgttctc aaatttccta gagaaatata ggattggtta gaaagggagg 101160
gattagaaat tatagaaaat attccattat tttttcacat caaaaccaca aatttatgta 101220
tctccttaaa tgttgttttt atttaaaaaa tgttttatta cttctcagga gatctcttag 101280
taaatccaga tcaaccaagg ctcaccattc caatatctca gattgcccct gacttgattt 101340
tggctgacct gcctagaaat attatgttga ataatgatga gttggaattt gaacaagctc 101400
cagagtttct cctaggtaat tctttttgtt aatttgagaa taaaaattag gatgtaattt 101460
tctccttata atttagaaaa tagatttcat aattatattg tcatagattt tactgtcttc 101520
atatatttgt tataattttt gtatttggaa tgatatattt taaaggaata taatattaca 101580
gatctggaat ttgttttgca cataatcatg tagactagga tcaagatgag gatgagatta 101640
tcatggaagc agaaatattt atgaaatata tctttgtatt tgccttaatt gccagggata 101700
tgggaggcaa ataagacagt tttcaggtga gttaagtgaa gcagccatat tttataaaat 101760
gacagaatag gtaaaggaag cacacctcag tgtagccata gcaggggttt tatgactcag 101820
tgtgacaatg ctgaattctc atagaaatat tcattaaaag ccttgaaatt aaagtcaaaa 101880
gtgttacatg gtgacatact caaatacttt tttttttttt tttgatatgc tgaacaattt 101940
acatttcttg gttccgtgaa ttcaatcagt gattttcagt agagtatgat ggaaatcatt 102000
gaattcatgt agcatgttta ggtgctcatt gagaaaaggt gaagtcatgg taaccatgtt 102060
tcaatattct catttgtatc ttgacttcct gcacatggat ttttgggcct aaaagatgtt 102120
tttaaaacat gctcatacac ttcagaagat gaaaagtgta tgcattataa ctactttggg 102180
aaagaaacag tcaacatatg ttactgtatg tcattctgta gattacatgt gtggtttctc 102240
atgtctctca gaataaaagc taatgtcttt acaagacctg cgatgctgtg atctgtctgg 102300
ctcctcggtt atcattttta aaaaaagata tactttgtac aaattttttt aattgacaag 102360
taaaaattgt atatatttat ggtgtacaac atgatgtttt gatatatgta tatgttgtgg 102420
aatggagaag tttagctatt taacatatac attatctcaa atatttatgt ggtgagaact 102480
attaaaatct actctcatag caatttacaa gtatacagta tgttattatt aactgtaggc 102540
tgacatactc aagttttaaa cattcctgag agtcattggg acaactatga aatgcattag 102600
attgatttaa tataaagcat ttgaagacaa ttttgacctt actttgttta gtttttgttg 102660
ttgttgtgtg tatacattta attttaatca aattacccca gaaataatgc ctaagatctg 102720
tcagtcagga cataatatta ttagcaaaaa gttgtccaaa atttgagaca tgatatttaa 102780
agctaaataa actcctttat acccctctta ttggcattga ttgggaagtt taggttgaat 102840
ttaaatgctt tggaactcag gaagttaatg tattagtaat agtgggttaa cataaaatgc 102900
tgaattgtcc ttgctgaatc ctacatctta accccagact tcaaggtata caggaaagta 102960
ccagacatgg tgcatccttc ctctgaagaa atcccaaact gtcagacaca gatccctaaa 103020
atatttcttt ttcctgcatt aaaatgtgtt tcagatgaat ggacacgttt tgagtagtgt 103080
atgtggaaac gtcatttaca aagtctgttt agttggccag gtgtagtagc tcactcctgt 103140
aatcccagca ctttgggagg ccgaggtggg tgtatcacga ggtcaggagt tgaagaccag 103200
cctgaccaag atggtgaaac ctcatctcta ctaaaaatac aaaaaaatta actgggtgtg 103260
gtggtgggca tctgtaatct cagctactcg ggaggctgag gcagagaatt gcttgaacct 103320
gggaggcgga ggttgcagtg agccgaggtt gtgccactgc actccagcct aggcgacaga 103380
gcgtctcaaa acaaaacaaa acaaaaaaca aaaaagcaaa gtctgtttag ctacccatat 103440
aggaaaatgt ttgtgattac tctcccttct ctagacccat gtcccataaa tccataaatc 103500
ccatgttcat ttacagaaag cagtctagat aggagtttct cagtctttga gctgttgcca 103560
ttttggcttg gataactaac tctttcttat cgagggtcat cctgtgcact gcagaatgtt 103620
tggcagcatc tctgtctatc cactagatgt cagtagtatc tccccttccc tcagatgtga 103680
caatcaaaaa tgtctccgga tgttgccaaa gataaggggt ggggttgaat accagtgatt 103740
taaacaaatt aggtgtatcc ttctaaaaac attttacagg tagcgactcc agcatcttta 103800
tattagagta atctggagaa ggttatgcct ctctcaattt tccctctttc catttttatt 103860
tgtagggcag caatgcattc aggcttttgg taactctttt tcccaagata gcagtaacta 103920
ttatgcagtg agtaatacga cccaccttaa tagatatgaa tagacttgtt ttgtgaatat 103980
attttaaaat ataaatgtat gggattctgt tcatgcgtct gagaagccac agggtacatt 104040
tcctctttgt ggagctattt atttttctgg agagccaaga caggtatttc cacttcagtg 104100
gtgtgatttg aggggttagg aaaatttcct tgccttcaat tttctttcca acctagatgt 104160
cacaaataca taatagtagt ccttaacttt atttttgttt tcagtcacct gaaagacatg 104220
acaatccata ctccatatta atgcagcggc gattctcaaa tagagaaggg ctttaaaaaa 104280
ttagaaatct ctgccgggcg cagtggctca tgcctgtaat ctcaacactt tgggaggccg 104340
agatgggcgg atcatgaggt caggagatcg agaccatcct ggctaacacg gtgaaacccc 104400
atctctacta aaaatacaaa aaattagcca ggcgtggtgg tgtgggcggc tgtagtccca 104460
gctactcggg aggctgagtc aggaaaatgg catgaacctg ggaggcggag cttgcagtga 104520
gccgagatcg cgccactgca ctccagcccg ggcgacagag cgagactctg tctcaaaaaa 104580
aaaaagaaaa aaaaaaagaa aaaaaaaaca actagaagtc cctactccaa cttgaaattt 104640
ggatgtatct ccctagagta tgtttcttct ctatgctgca ttgcaatttt tctttgttgt 104700
tgatagttgt ccagattgag gggaggcaga acaagatgca tctatatgtt tccatctctc 104760
cgaccgattc tctcccttcc ccctctactt gctttctttc tcttttccct cttctgttta 104820
cccgattcta tttctgattc cagtatgtaa cagttccctc tgaagctctc tcaataccaa 104880
caatcctaac taatggtttt taaaagtcaa atattaagta ctggagggat agaatgagag 104940
aataccaaga ctgataagat gcaaataata cttttaacat atttacaatc taatagaaat 105000
acaagacatg ctcaaataag ttaattattt taatatactc tctctgagca taaaatataa 105060
ttatatatgc tcattataga catataaaaa ataaataggt agaggctttc catagatgtg 105120
taatttcacc acttgaaaat tactatattt ccttatagac tgttttgtgt gtattcactt 105180
atatccatca agtgactaca tttcaaggca ctatatgaga accataaata ttgtacaaac 105240
aggatttgct aaatgtcggt ggagagtaac agtccacggg gctgatcatg gtcagtttgt 105300
gaggcaggcc tccaaactcc ttggggattg agatgatgga gtagcagagc tcttcaaggg 105360
tatggaggcc tgaaggtaca aagcatgctc aggaaatttt ggctattgcg gtttgtctag 105420
agcacttgtt ctcaacctta cctgctcatt actaattcta ctaagtacag aattaaaaga 105480
agaaaaaaat ctaatgacca tttcctcctg ggactaatta gatcaaaatc tttgaaccca 105540
gacattagcg ttttaaaaag ctcctcagat gtactattca gccaggactg gggcagggaa 105600
agctactgaa ctccagcctt gagaatgaga agtagaacaa gaggagaact ttaaaaggat 105660
ttaggggcca ctatatgact atggagctga atttagattt gatttagtag gcaacgcgga 105720
ataatttgtt tctgaacagg agagtgacac aatcaaagtg gaatgatagg aaaattaatt 105780
ttgcaagaga gagagaatga gttggaagta aggaactcag aaggcctcct gggactcagc 105840
agaaagctct gaggccacca aatgggtgtg gtggtagtgg aaatggagaa gaagggaatg 105900
taaatgaggc tacacagtgg actgccactg ttagccgtgg ggttagacca cagcaagagt 105960
taaaataatt cttcaatttt aactccagaa gggcctcaaa aagacttttt gtcttgttat 106020
catcagctat atggaaggta gaataaaaac tagttaggag aaaaggtaat aaatgtggct 106080
tttgataggc tgtgattgag ttggaagggc ataccagtga aatcaccaac acaaagttgg 106140
aagtgtagga aagcacttag gaggtggcta taagtgaaaa tgtgaaaatt ctctacatta 106200
aagggataga tgaagtcaca gaagtggatg acataattga gcagggtatg tgtagaggga 106260
agacgggaag gttaaggaca aaatctttac atatatcttt cttggagtag aaggaagagg 106320
aaatgttaaa ggagatttga ttcaatgaaa caagtaggtc aggtttctat tcaaatttac 106380
aacagatata attacaacag atataattta tttagttttt ttcgcttgga cagcttaatt 106440
taagtgcttt gtattttctt ttcaaaaggt gatggcagtt ttggatcagt ttaccgagca 106500
gcctatgaag gagaagaagt ggctgtgaag atttttaata aacatacatc actcaggctg 106560
ttaagacaag taagaaattc aataatataa ttatattaaa ttgcacatta ttaatctact 106620
ggaactctta ttttgcatac agttgtgaaa atgcaaaata atgaccacat ttctacttaa 106680
gtttaattat gcaatcctag tttgtctttt cgttgtggag tagaaagttt tgtgttattt 106740
ctcctgttga gaaacaaaac actgtatctg agaatcctta taatcgtgat acatagtgtg 106800
ttgtaaaact ttttgtaaga ctcacttaca ctcctctttt tactttagaa ccttgctgtt 106860
caaaatgtgc tccatggaca agcagccagg cattacctag gagattgtta gaaatgtaga 106920
aacttgggac ttttcagtgc catattattg ttcctgatac tccacagtag tcagactcct 106980
agctgcctcc acctgcttcc agaccttgaa gcctagcaag ctcctgactt cgccttctgt 107040
tttcttcaga gtatttatct tttacttttc tggtctaggg agagaatgat ttttattttt 107100
attgaacatg acttctgtgt gttcagggtg aaagaagaag tttaatgcat gatctcacat 107160
tgctaatttg attgaaggtt agaaatctta aactaaaact ctcactgata agcttgcacc 107220
tctcttttct ggatttatcc actttaataa gaactgctat tgattacttg ctacaaagat 107280
ggagaaagtt agcatgctta tcctatttcc tactccctgt ccctgtccac ttcctaaaac 107340
ttaaaattgg ttgcattaat tttcctgata tagtaacaat tataacttgg aatgattttc 107400
aaaacttttg tttttttagt ataccaactc tagacagcat ggactgactc cttgctatgt 107460
gagatgagga aaattaacgc tattctttct ccttttccca tcaccttctc aagttcttta 107520
atttattcta ttatttttat gtagtgaaag tttataacat ttatattctg gtctgtactc 107580
ataattaaat tgttcacatt ttgtctatag tttggttctg agaacaaaac caataaatgc 107640
catttatata tttttttatt tgtacagaac caaaatattt ctacttctag ataaagaaat 107700
gcaaccttct gtcactaact tcttttacta atagaatagt aacattccaa atatcaaagt 107760
caaatggatt ctctattgtt atgtatttat catcaattta taaaaataaa ggcatatttt 107820
aatttggtca catttttacc ctgatttaaa aaaaaatttg tttttagaga tggagtctca 107880
ttaggttgac caggctggtc tggaactcct ggcctcaagt gatcctctca ccttaacctt 107940
ctgagtacca gtggtgattt attttatgta gctttttgag gttttctgat tatatacata 108000
tatttttaaa aaacgtactt caggaaaaga tatatatttt catcatgact tcaagtgttt 108060
ctaagttctt aatcatacag tttgtataac agaatctact ttcttcttga agacattcct 108120
cattcagcac atgacttact gctctaaaca ggagagatgg atttctaggc tgcttgtgca 108180
gtgattaatc tatgagttag tttcctcgcc ctctttgatt actctcaata tttcttggat 108240
tccatccatt ctcttggttg gattgtcctt agtttttgtt gaagaatatc ttcgagtaat 108300
ttttttaaga aaaggtgttt gtgaggtaaa tgttttcagt ccttacatgt taaaaatatc 108360
ttagttttgc cctcccatgt ggtggatatg tcatcacact ttatttttta ggaatctagg 108420
cttgaaacaa ttttcttcaa aatttgaaga aaattccatt gatttttagt gcccactgtt 108480
gctaatgaaa agtctgcagt cagtcagatg tttgctccta tctaggatac ctttaatttc 108540
attttgaaaa ctgaaaattt gaccttttga atttcatttg ttttcagtgt tctgaacctt 108600
tacaagtatg tgtttgtgtg taggttgttt ttcattccat ctaattcatt attttgtgaa 108660
aaattgtctt ctgtgtattc tcttctatta tttattattt cctccctaac atttattaat 108720
catttttatt gacaactact atgtaccagg ttaggtgatg ggacatatga tatatatata 108780
gtagtaagct aaacccagtc aaggctctgc ttctctggag cctatatcta gttacttatg 108840
attcattatt gcttatcatt gctccaagag tatatgttag atgacaagcc ttttgggtct 108900
atcatccatg tttgagttcc ctcttcaagt tttatctata atttgtgtta cttacttgac 108960
tgtctcttac aggtttctaa tattttttag aattgcatca tctattattt agctttctgg 109020
tgaattttgt tttgataatc atattttcca tttccagcaa ttctttccat cccctctggt 109080
tgttcctttg tagccatgtt tttggataaa atgtccatag gtgtttctgt tcatgtcaat 109140
tagaattttt ttttgtatta cttgcattat tgcttttttc tctgaggtta tttgctctgt 109200
gggttcatct tgatctttct cttttatctt gtcagttttc caaattgagt agttttgggt 109260
gacttcgtat gaagtaagta ctctattgat tgttaaagaa ggactgtatt gattattaaa 109320
ggtaactaga atgggcattc ttcacattca tgtaggtttg cttgttcaag ttaccacttt 109380
ctgaacaaga aggttagacc atagactttt aagggctgca tactgcaaag ggatactctg 109440
ttctttaggt tacatgggca gggatcactg ctgagaccat acctgccaaa ggaaggcagg 109500
ctttgctctc tagatgctgg acttgaaatt gtttcccctc tgcttagtgc tgcattattt 109560
tttttgcttc ttaatctgct gcagagtatc tagatcaggg tgtccaatct tttggcttcc 109620
ctgggccgta ttggaagaag aattgccttg ggccatatat aaaatacact aacactaatg 109680
atagctgatg agcttaaaaa aattacaaaa aaaaaatctc ataatgtttt aagaaagttt 109740
atgaatttgg gttgggccac attcaaagcc atcctgggcc acatgcgacc tgtgggccac 109800
aagttggaca agcttgttct agatacttca gactctgttc tacatctctt catagatcaa 109860
taacttgcag caatgagttt atcagataaa ttatgttcac ttttcatcca taaaaaaagt 109920
catgggaggt actcaccata ggattggttt aatccagtca ctctggccaa ttttctttaa 109980
aattccttta accttggtat attggtttaa ttccttcaga atggcttttc ccattgtgat 110040
aaactggttc caggcttcac gagtacttat tccaagtaca gaaggaaaga gggtacctct 110100
tttgagtact tgtatttcaa aggaatcaaa tggcctacat aataacccat taaataaata 110160
gatgtctctc agccccagtg agtcatctgt gcttttctca acaagcacta tgttcagggc 110220
aatgctttgt gctaattggc tttaggcctt tgttaccaaa ctgatcactg tggccctgag 110280
ggtgctgtta cttagaatat tcccaccttt tctgagaggc tgatgttggg gtcacttccc 110340
cctgaactaa agtccagggg ctgcatgggt gagggttgag taactcagta ctctaaggag 110400
gaaaggaagg ggaatataca ctgttagtta acagtggtta ttcctgtatt ctctcttgtt 110460
tggattctac tggggatttc tttctttttt tgagtcttta ttgacattag gaatgagaga 110520
tagaaacagg gtgagagagg aagtaaaatt aaatgtgaat tcttccatct tataccagaa 110580
ctcaactgta tttttggaat ctatatatcc ttacttttcc cttgatttat tacaaaaaat 110640
tcttagtggc tacactaagt aaattttgta acctttaaaa aatacatagt tataatattt 110700
taagtactct gagtaataga agatttcatg tgagtacaaa atatcctggg ggcattttaa 110760
ttattagtaa caacagtcac actgtagttc tagaaccaaa ttgaacattt tatatataga 110820
agcttatctg tgaatcaaat ctgacataat ctcttttaat gtgtaggtaa tttcttatat 110880
aaattgattt tttggccttg ctgtcagcat gcatttcaaa ttttacacca tgtgtttggg 110940
gagctatggt ggaaattagt acattaaaaa tgtctacaga gccaattagt gtataagcag 111000
ggaggcaaac taagggaatg gtggaagaaa ttaaaaaaaa aggggtgtgc ataatgtgct 111060
tcttctctta aaaaaaaaaa aagaaaaaga caacaacaaa aagaaagaaa aatgacattt 111120
gacggtcatt ctaccagtag tcatggggca gatctatatt atactgtact attacgctgt 111180
tttttctttg caattagtga gttgcttttc caggatagaa aatttggatt agacctctgt 111240
ctgtgcctat gaaaacaagc agagctaact taactccttc tcatcagttc taaccaactg 111300
acatgggcat taaaaaaaag attttatcta ctaagcaaat atgatcacag tctgaagctt 111360
tgttcttgga aaatcccctc tcagggtgtt cagcctttct tcttcagctt gcagaattct 111420
ccatgtttca gtttcctgat aaatcagtgg gcgccgctac tccacatctt tgaagctggt 111480
tgttaagaag cagtgcttct gcagcaatca cagtttaaag catgaatcaa tttaacatca 111540
cacaagctat acatttcaac agagttacag tttcagagta aagtgcaata tacagtataa 111600
agcgaatctg gaattcaagc ccaacaatgt cataaaagag gctgtgaagt ctcacatgat 111660
gtgggccaca gagagggttg ttgccattgg atcttagctc aaatactacc acatcttcgg 111720
agtggcctgc catgggccac ccttactaag gcaatccctc tgtccaagcc aaaatgatat 111780
ctcggacttt ttttgaattg cagagagatt gttgcagcca gggattgcct tagtaagggt 111840
ggcccatggc gggcctctct gaggatgtgg taatatttga gataagatct gaatggcaag 111900
acttcagcca tgtgaagggt ggagggattt ctagggaaag gggtcagcac aggcaaagac 111960
cctatgatgg gaagaagctg ggcacagctt gggattgaat gaatgccaat gtggctgaag 112020
ggtggtgatt gaagaggagg gggagacgag aaggtctgga aggcctgggg catgatcaga 112080
tcaggtgctg aggccgtgga agtagatggg attttcatct aagggaaatg ggaagtcatt 112140
agagagtttt caggagggga tgatatgtat ttttttaaaa ttgagcatta tcctcggtaa 112200
acttttgtag tcgttaaacc agagattata agcaggtttt acctcatatg ccagttgcag 112260
ctgattagta gtggctatag agaatcctgg gctgagaagg atactgtggc taaccagaat 112320
tcagtagatg agtttgacgt ggcctgttag tatgactaca ctgtgtgcac tgtttctgca 112380
ttaaatgtct gataaaaaca gagccaaagg aaaaatagaa cttaaaaatt taattctgac 112440
agtacagttg acccttgaaa aacataaagg ttggggtgct gaccccttgt gcagtcacaa 112500
atttgcatat aacttttgac ctccccaaaa aactgaacca ctgatagccc actgttgact 112560
ggaagcttta ctgataacat aaacacttga ttaacacatg ttttatatgt tatctgtatt 112620
atatactcca ttcttaccat aaagcaagct agagaaaaga gtattttatt taaaaaatca 112680
taatgaagag aaatatattt aatcttcgtt aagtagaagt ggatcattat aaaggtcttc 112740
accctcatca tcttcacatt gagtgggctg aggaggggga ggtagaggaa aggttggtct 112800
tgctgtctca agagtggcag aggtggaaga aaatttatgt atatgtggac tcatgcactt 112860
caatcccatg ttgtccatag gtcaactgta gtttcaaaac cagcttttta ttactgaaaa 112920
tacgggaaaa aaaactcaga gaagaaatgg aaagtttgct atgatccagt catacagaga 112980
aatccatgtt cagcctgttg atgcacttta aagaaggaga tacgtgggta aaacctgatg 113040
ttgaattact cttacatgat tttggacttt tgcaggagct tgtggtgctt tgccacctcc 113100
accaccccag tttgatatct ttgctggcag ctgggattcg tccccggatg ttggtgatgg 113160
agttagcctc caagggttcc ttggatcgcc tgcttcagca ggacaaagcc agcctcacta 113220
gaaccctaca gcacaggatt gcactccacg tagctgatgg tttgaggtaa gtaggtcatg 113280
ttgttttcta ttcagtgcat gacaagtgtg atccagactt gctctcaggt tctgagaaca 113340
cttcccagta acactgtgcc ccagtaacaa tttataaaca atttggatga aaactaccat 113400
ttccctgatc aaattttgta atttcagaaa ataagagtat ggaaaccatg cagaacctca 113460
tagcaagtag taatagactt tgaacccaca agttctgctc tagaacccat catcttaacc 113520
ctgtactgat ctgccttcta taaaaatgta taagttaggc ttcacagtat caaagtaagt 113580
gtcaattaca tgattccaat gaggaaagat gagtccatac ttctcaaggg gactagagtg 113640
attcatgttg gattcttcgg catgaccatc tcacatgtct cagaggcaca cctaaccctg 113700
catccagagc aagctttgga gagggagcac actggagtgg aaaggctgtg gtctttgaag 113760
acaaaaggcc tgggattcat cactattcca cacatttagt aactgtgatt ttatatctct 113820
gattcccatt ttttaaatag tctgtgaacc atgactaata tttaatgcat aaaattatga 113880
tgacttctgt aataattgga gacattccag atgaaactct tgatgtcccc tctgccattg 113940
ctccccaacc ccagtcaccc tgttacacct gagagtcacc ttacattcct ttcttcctct 114000
ctcatttcac agctaatcct tcagcaaatc ttttcagctc tgccaccaaa atatatctta 114060
atgcttctaa caatttctct cactaacgtc taaatctgag ccagtatcat ctctcattgc 114120
ctactggtcc cctgcttcta cctctgtctc atgatagtcc cattcctcac ccagcctctg 114180
gagtgatttt tctaacatga aagttggatc aggacttgtt cctgttatta cccctcccct 114240
gccttatttc ttgggtacag tgctcagcca ctcccatccc tgaggttcct tgcagatacc 114300
agaggcttta tatctgctgt tgatttcact caggaatgtc tgactcccag atgtgctctc 114360
tacttattat aaaggattat ctgaatcttt ctgaatcctt tcatttagga ctctcagcag 114420
agaggatgtc cgcaacgacc ctttgtctct ccagccccta taggactatt gctgcctagg 114480
attctttatg ttttcatttt ttaaaaactt atttattgtc tgtcttgcca tcagaatcta 114540
agtaccatga aagaagggac ttttcgtctt gtttgccatt gtatctctag ctcctaaaat 114600
agtaagcctt cagaattact gtgttgacag taggggaagg gggagaaagg aggaaagaag 114660
gaaaacagtg cctggggcat agaagccaag cagtgtatgc aactttcctt ctcttctttc 114720
tcttctgaaa tgctatgaat atgcctttta ggtagtatcc agaaatgttc cttcctgaaa 114780
gggtccagaa actactgaaa actgtacaga ttatgaaatg aaacagggtg cagggatttg 114840
gatttgagtt gatgtttctg cttttgaaca ccagggggaa tcttgggtta cattaatcta 114900
ggtaaagtgc agaatagtct cctgtatttc agtgccctct ttccttcatt taactaactc 114960
taggttctag tttttcccta attcttccac aaatccccaa agtgtttatt tataaagtga 115020
agaattgcta ttttttaaca ctgttcgaaa caccttatct ctaaaatgac ttattctagt 115080
tctctgaaac cttactttaa ataacaaatc cagcagtttc tgatgaagta aatgaaatgt 115140
cagcatattt taaaataatt tgcctaattt gttcttagca taatgccaga aaagctttct 115200
ggattttgta tcacaaaagg ctagtagatt tcagtagcta tcaatcttct accagcacta 115260
agtatatttt aaaaactcag cattaaggtt tatttttcca agtatgtttc agcacaggaa 115320
ataaaatcat gctcctttgg agtcccttaa atgctggagc tgtttagagt gacatacaag 115380
aactttcttc acgttacatg ctctctcttc ctccatcttg cttttaactg ttagcttact 115440
tctccaattc aatccacttc gtttgaactc tttatcataa ttctataaaa cttatgaaaa 115500
tacagtcaac tgcattttct gtatgtttct gtgtttcaat atcttcaaaa tggaatgtac 115560
tgccttggta catcacccac tatgaatctg ttatttctgt tatatcccac agttgccagg 115620
ccaggatact tgtcccatcc aggccaaaca ccttcccccg aaagcaagta tgcatttgtc 115680
caccaggtcc ttgactctat tttacattat ctttttagtc aattcattta tttttatgcc 115740
actcctgctg tcttggttca gtatgtccag ggaattatca gaatttcttt tctaaaataa 115800
aaatctgttt atgcttgcaa ttccttgaca gttctcaatt atctgcaaag tgcatccaaa 115860
cttcttggca tagcatcaaa gatctttctg tatgcctctt gcttcccttt gcggcccctg 115920
ccaccccact gcccacactg cattctagcc gtgatgacag gcttgaattt tcagttatgc 115980
tcatgtctgt ccatcattgt atttgttatt cctctctttc caccaagttg tctgcctaga 116040
gagctcattt tccttaagaa tttcttcaca aaccatctct actatgaagc tcaagtgtgt 116100
catgaagtgt tagcttctcc aacttgtgtt tcttgcagac actctgtgca agacattgac 116160
ttaggtgcta aagagggaaa gctagatatt atattgttct tgaggttgaa agcttacagt 116220
ctagtaggag agtcaacttt gctgtcttta cctcagtgtt tttctccctc tgtgcttccc 116280
tagcacgtgg tacttacata tttctggaat cttgattaaa cacctgtttg aggactgtct 116340
gagcacaatc cttctggatt gtgacaccct caagggagca gagatacaaa gatggctttg 116400
tatactaaat gactggccct catagatacc tagtacatat ttgtcaaata aatgaatgca 116460
ttctattttt ggaataattc tattcagaat cagataaagt ttactttaag ctatgaagaa 116520
agaagtctct tagcaactct tacaataatc acaatcaaag aatgactgtt taacttaata 116580
taaaccagtt tgttttaata aaatatttga caatagtcat ggttacacaa tgcataaatt 116640
atggctaaat tattatcagg aaggaaaaat ctttacttat tatttcaaaa gctattttgc 116700
tagtctatta aaagctatta gaactgcact tcttaagatt aaattctata attgaacatt 116760
ttaactaacc aagatattat ctctttgcca ctgacattat ttcaaattaa gcttaactat 116820
ttctttttag cctttggaaa gtattctgaa agagtctgtg ttctataaat atacttaaag 116880
aggcatgtct tataaaggat ttggatacta ttcaatgatg tatgacttgg ctttagcttt 116940
tttattctta atctctcagc ttttctcttc agcaggggaa gagtacctaa tggcctttca 117000
gtaatccctt ggtaaatttt tctttcaagc ccattactta ctgtgaaggt caacttcatt 117060
agtgtattta tcttattttt ttcagcccaa aataggtata ttgaaatgaa tgggcctaat 117120
gtcaaatgtc ccgactacat cctggaagag agagaatctt cagctgtatt agttgatgca 117180
gttaaataat atgtactctc caggccctca tacaattgaa agttcagggt atcgttgctg 117240
ctctgcttct aatccttcca gaagtgattg gtgctaggtg atggagtaac tattaattga 117300
tataatgtga gccaaaacca acagtcacga ataagcaaag gatttaaatt taactccatt 117360
aagtcttgtg agaaattatt ttcaacatag gttataacat acctgtgaca tcacatgaaa 117420
tgctgtagtc aatttgacat catggggcag agaagacaga gttggaaatc agaattttat 117480
agacatctaa tgtgataata acattagtag ctgagatgcg gtaagctctt tgaccatgtt 117540
tccagaatgg ataagacctg gttgagatga aaactttaca ctgttttttt atattaacta 117600
tcttttactc tttgcctgaa atgtccaact ctagttgctc gtgattgcgt gggtcagtct 117660
ccagaaggtt ggactttaat attacccgtc atcttttcca agacaaaatt gtattcattc 117720
taactcttag ccccaaattt tcttttttaa ccttaatatc taacatgatt aggtttatgg 117780
taaattatat actcaaacag aagaagagac taatagcaag caaaagtctt atattttcat 117840
ttgttttcat ccaaaaagta gaaaatattt tccaaacatt gggaaacatt ttagtcagaa 117900
aaataaatat caatgataaa tagaatagag aaaaatttta aagctgagct aaacctctat 117960
gtggttttag gaaaatcaaa actattaaat aaatggcaag tacaacaaaa tcccatcaat 118020
tcttatttaa catacttaca ttttgaaata gttaaaatat tcatatgatc attgagagaa 118080
ttcagaattg cctttaagta attgttcaca tatacaaaag aaaagtctcc aaaaattggg 118140
tctttgcctg agatagattt gtcttaaaat tgaaatcatt cacttatcag atttgaccct 118200
tttttaaagc ataactttgc tgtgtaatat tagacttata tgttttgatt tccttctaca 118260
atatctctta actttaaggg acaaagtgag cacagaattt ttgatgcttg acatagtgga 118320
catttatatt taaggaaatt aggacaaaaa ttattataat gtaatcacat ttgaataaga 118380
tttcctgtgc attttctggc agatacctcc actcagccat gattatatac cgagacctga 118440
aaccccacaa tgtgctgctt ttcacactgt atcccaatgc tgccatcatt gcaaagattg 118500
ctgactacgg cattgctcag tactgctgta gaatggggat aaaaacatca gagggcacac 118560
caggtaggtg atcaggtctg tctcataatt ctatcttcag gatggataac cactgacctc 118620
agatgtgagt tcagaagagt caaaaggaaa acagagtcta tcacattgtg aacagaggtt 118680
tattttgtga aaaaatgcaa gcatcacatt gtgattttta tcattgtatt ttgtaggaaa 118740
aaaacaattg atgtaatttt tcagggcaaa aactgaataa aaagaagaga atgtttgata 118800
tcaagttata tgttttaaag ttagatttgt agattcttta gatactctag aggtcataaa 118860
aagtaacagc aaaaacttta gtctaggtat tgttggcact tgtgaggcaa atcaaattca 118920
ggtccacaaa ttctttttca taattctgaa acccaaagaa ctctgaaaat cccaagattt 118980
tttaaaaaat gactaatttg gtgtcaaaac ctaagcaagc tgacttgttg cttattacaa 119040
tctttatttc tcatgctcag tgtgaatatg catacatttt gctgcagaaa tatatacatg 119100
tttgagtaca gggggctggc cgtgacccta ctgagggttt ctgtacacat cactgtctac 119160
cctgtggaat cttacctccc tttcttagtt cccaatcctg aaaagcagtt atggggccag 119220
tgctctgtac agacatgttg tctcagacat cagtttgagc aggaagtaaa tcatttaggg 119280
gttggcattt gtttggagtg tggggaacac tctatcttta gggaaacttt atatagttag 119340
ttatttgtaa gtaaaattac aggtggctat acatcatctt gctgattgca actcaattaa 119400
atcaccgtgc ctggcacaga agaaaatatg ctacaggata tctcactagg gaaaaggttc 119460
tagttcgttt cctgcgcact caacttttgt acttagataa gcaaatggcc ccagattcca 119520
atgcctggtt ttatttttgc tccaaataca tatatactct tttgttttgg atagttacat 119580
tttagaagta gactgtgtat tctcataaac acttcaaagt gtatgttctg gctgagagtg 119640
tctctgtgtt gttcaataat aataagacta attatcattt tttgagtacc tgctgtgcgt 119700
caggcccagt gccacgtata ttagagacaa gatctcttat cctcatgcca gggctggaag 119760
ttagctatta gtttctcatt tgccaaatga gaaaactgag gctcagggag attatgtaac 119820
ttgcagaata tcactcagta attggccaag ataagaattc agtctaaatg agaaccagat 119880
ccagagatat ttggctttaa attctatagt ctctcctaaa ccatatgcaa ctctaacatg 119940
aagaagctta tttaatcttc actattaaaa aagtcaaaac aaaacaacag agccatgaat 120000
agcaaatatt gtcaatgaga ggtttggaaa aacagtctta aaggatgaaa ttccatagac 120060
ctgatatatt tccacctgga aaaagtgggc atgggacagt gattttctct tgaaagatct 120120
gctcattttt gtcatgggac atgaaggtgg actggaccac tcagtttctt ctttctgcat 120180
ctcccaaccc agtctttctg ttcatggggt gaaaatctgt tgttgaagcc ttgtctgctt 120240
aattggacag tggatctctc gggtccctgt gggctgtgcg cttgtacttg agctctgctt 120300
cttcactctg tggtctaggc cagctagcag ccagctgagt tcaccttggt tcagactcat 120360
ggcctttcat tttcagtatc tgacttcctg gttttgctga aaacctgtct aaaatgtaat 120420
atccatctga ttcttcatac caagccacac aattcttcct gatccctttt aatctccaat 120480
attgaatggt ggtaacataa atatggagac agatcatgtc agaaacccag ggcctaatct 120540
tttcttttct gcctactctt ctcacaggct gcttagtact ttgtaagctt tttttttttt 120600
tctggctgta acctagattt tctctttatc attactctat ttattattgt tagagcactt 120660
ctgattatct cagccctaaa ctctgcctcc aattttaaat aacaataact cccactcctg 120720
ctaatactgc tactactact accatcacca aactttttct tccccaaagc agttctgttt 120780
gggaaggaaa cagttccctc tcatacaatt tcagttatct tcttgtcttt tccgtttaat 120840
gaatcttcct gttaatgtta catcttttaa catggaaact tctagagaaa caaaagacga 120900
tggatttgtt aaaccttttg ggtgtatttt tatactaact cttactgcag cgtgtgcatt 120960
atgagtgtag gtccattacg gctgtattag gagcagaacc ttccagagca tgagcgatgt 121020
gctgggcttg tgcttagctc tatccatgag ttaagtatct caatccttag gaccctctga 121080
catatgtgct attattattt ctagtctata gatacagaga ctaaagttta gagaatataa 121140
aaaaacattt acaaggtcct atgggacaaa aactgtagga caaaatgcaa acccaagcag 121200
cctgagagca gagctcctgg tccagcactg tgatagctgg ggacgcagag acagaaacaa 121260
tgcaattatt gacagggacc atggtgctgt gtctgtccac attttgaaga taattatggt 121320
ttggatattt tcacctttaa ataacttgga gagtttcaac attaactcag tcagatggat 121380
acatttatat catatcctgc tgggagtgac agttaattct gggtcctatg gcaattgcac 121440
ttttgactga gatgaatgct gactgatggc tttaacattt aactaatgcg atagtattta 121500
acacacccat ataaatacta tagtcttcgg gtaaataaaa tgttaccggc tggacataca 121560
tgaatatctg atggagatta tggaacatac tctactcata cttctctgaa agtaaaaaat 121620
aaaagatatg tttcagtaca caatgtgata tgtactcaga cttaattcat aaatttctct 121680
tatccttcat ccgtggatct tttctttatt tacttattgc gtttgttaaa atgcaggctt 121740
ctctgaaaaa ttatttttaa aaatagtttt tagacaatga atcatatttt ctcaagtatt 121800
ttaacattgt aatcattatg ataattatcc aaggggaaat tatacttatt ttttattcat 121860
ttattcattc atttggcaac aatacattga acatttacta agcatcaaac tggctctacc 121920
acttaatagt ggcatgatgt tcatcaagaa attgttagtg caatcaagaa cactagaaat 121980
tcattggatg aatttaaaga agcttttaga agggtattat attataattg aggcacttta 122040
tgaatatata aataatatta tgttttcatg ctagagatca tgccaatgaa gatatttact 122100
ttgaaaagga gaagattaga agtttaaaag catttccata ttgaagtaaa tattcatttc 122160
catatcttca cagttatctt tctctgagtt ctctgactca ttgtgaaaaa aaatcccaac 122220
cttcttcaca gctctaccat cttcggattg ttgcctagag gggtaaaaac tattgtaaaa 122280
ggatgtgtgc actggatgag aatttagaat tagacgaaat gacccctaga gtcttttcct 122340
gctttaagag cctgtgattc caaattctaa cagtacattt atcaagaaaa aatatgctga 122400
acatttaaat agtttttgaa tagtacctag atataataga tacctaataa atgtgctcaa 122460
tgaataataa ataactggtt aagatttaaa taagcctcca aaatctcttc cacattctaa 122520
gaagggaagc ataaaggttg ttaatgaact agtgactgtg tgggtagctc attattttta 122580
agtactcttg actttgctgt tcattatctg tgtggcctta ggaaaataca cacatttctg 122640
aaaggattat gtcgtttgta aaatagaaag tccttatctg tctaccacag atgattctta 122700
tgcaaatcaa atgaaatgtt caataaggtg tctgtaaaat agtagagaga gatgaattag 122760
gagctattgt gatttgttta cattatgtca caggtgcact ttattaggga tatgttttat 122820
cttaattaca caattcttta acttagattt tgagaattat attatggtta tataggaaaa 122880
tgcccttatt ctaaggaaat gtataatata tttaggtctg aaacattgta tctgtaacaa 122940
tatagtatgt aaattatgct aattcacatg ataattatat gtaattatat taatatatta 123000
ctatgtatac aatatattta catgcatata tgtggggaaa tgttatcagt tagtgtagta 123060
ggggttatca tactcaaatt cgatgtctcc atccttccaa ctcttcatgc ttttccagca 123120
tggtgaggac tgctgagctc catcttttgc tggtagtctc tctgtcaaat agaactgttt 123180
ccaaattcag tcatttgctc cttgaaggct atgaattcat acttcgttat atttttctgg 123240
ctgcatattt aaattacttt aacaatcata taagttcatt gtaaaaattt tggaaataaa 123300
aaggaagata aaatgcacag ataattttag caaatgaaat aataattata ttgggatgta 123360
tttcttccta gattttaatt atgtacattc ccatcaactt tttattttga aaatgtttaa 123420
gcctaaagaa cagttgaaag agtagtacag gctgggtgca gtggctcctg cctgtaatcc 123480
caacactttg ggaggccgag gtgggtggat cacttgaggt caggagttca agaccagcct 123540
gaccaacatg gtgaaaccct gtcactacta aaaatacaaa aatcagctgg gcacggtggt 123600
gggcacctgt aatcccagct actcgggagg ctgaggcagg agaatcgctt gaacccagga 123660
ggcagaggtt gcagtaagcc aagatcacac ccctgcactc cagcctgggc aagagagtga 123720
gactccatct caaaaaaaaa aaaaaaaaaa aaaagaaaga aagagtagta caatatacat 123780
tcatactcat atacccgacg cataaattca ttgattattt actttttgcc ctacttgttc 123840
tttcttgctc tctttgcgta tgaatgaatc attgaaatta agttgtagac atcatgccat 123900
atcacctctg aacagtgtgt atatttcttt agaataagga tgtttactta cataatcata 123960
ataccattat cacagctaag aaaattaatt cagttgattt tttccacata tttgataact 124020
ttctgtctat ccacgattat gtcttacata ttcttttaat ttatgtcata gcatatcatc 124080
ttagaaagtg atccctaagt tactgcatgg tatacattgt ttaaccattt ccctttgtga 124140
ttggatgtct ttaggttgat tatattttta ttattatcac aaatgttgaa atcactcttt 124200
ttttctgaag aatttaaaag taatttatct gtcttatgga ataaaatatt tatttcccct 124260
taaaagaatt tcaggcatga acccaagaga gaaggctttt ttttttgttt tagttgttgt 124320
ttttattttt attttttatt ttttgggtag aaggagcaga gagacaagtt caggaaataa 124380
tgagagtgtt agaattttgt tcaggttaaa gtgagttgga gtgaagttta gaaatctcct 124440
ttctactcat ctctcctgtt tttaaaacac tgtcctggaa atagttaata ttaggaacga 124500
gaaaaatggt ataggttttc ctagtacact ttatttctta attatgaaat tctacttaat 124560
aacttaccat tgaatgttta tccttattat cattcaaggt aattttattg aagattgaag 124620
atatttataa taaagattga aggattttat tgtcctgtgt ggtcaacctt ggggggtgag 124680
atgttatgag acaggacaat taattgactt gatcaaggta ccttgttata aaaataacac 124740
agcctggttt agaacatctc ttcctgactc tcttatttgg catatagcct aagtgtatgc 124800
ctccttggat gtatgagccc tgatgttggt catatttatt attttatctg cttactttca 124860
gggtttcgtg cacctgaagt tgccagagga aatgtcattt ataaccaaca ggctgatgtt 124920
tattcatttg gtttactact ctatgacatt ttgacaactg gaggtagaat agtagagggt 124980
ttgaagtttc caaatgagtt tgatgaatta gaaatacaag gaaaattacc tggtaagttc 125040
tgttttctct acaatgaaga ttttttttct taatatcagc agcttcattt ttatttaatt 125100
gtagttgtat gcttaattcc ttaaacagat gatcattttt tttgtttagt gcataaatat 125160
tcttaaatct tgtgatatat taataaaaat cacctgaaaa aggtagcagt tttaggcttt 125220
ttaaaaaatc cgcaattaat attggtgtag ttaatattat atttagaaac atagagaagg 125280
aaattgctgt tagaactcca catttggtga tttttaattt tcataaagaa ttactgtgta 125340
ctcattatcc tggaatgttt tcgttttctt ggagtgaaat aatttacatg caggaatgga 125400
agactgaatg atctataata ataatttttc ataagaatcg gtaaatgtgt atttaatgtt 125460
atcaaagctc atttggaatg gttgtctcat gctttcaaga aattagagga ctttgtaatt 125520
cattccttaa ccattacttt agttctcacc acaaaataac attttaagtt tatttagctc 125580
tttctcatat tttctgcttt ccctttcatt taaaaaatac ttttgagtgt acacaatgtg 125640
ccatgtacag gaaatagagc tttatctttt ttgggtataa cttcaagatc atggcaaaag 125700
aaaacttatt attaattgga taaaccttag atataatcta ggttatttcc cttattttac 125760
tagttttcta gtgaaaatat tcaggtctct gctgggtaca gtggcttacg cctgtaatcc 125820
cagcactttg ggaggcccag gcaggcagat cacttgaggc caggagctgg agaccagcct 125880
ggccaacatg gtgaaaccct gtctctacta aaaatacaaa aagtagctgg gcatggtggc 125940
atgtgcgtgt agtcccagct accaaggagg ctgaggcacg agaatagctt gaacctggga 126000
ggttgcagtg agccgagatt gcgccactgc actccagcct aagcaacaaa gtgagactcc 126060
atcttaaaaa aaaaaattca gttctgtgtt ctgcatcaac cagaataagc tacgcctctt 126120
ataaaaaaca aatgtgcaca aaccatctgt gaggacataa ggattaaatg cttgcttact 126180
ttgagtatta aaataaaaag tagaagcttt attatatgag taaaagtgtt tccaaagtct 126240
atttgaaatg caggtacaga atgaaaatct gttattttat taaatcgtta tttgggtctc 126300
tttttattcc ataaaaaaaa aatcttttcc acatctctta gtggagatca agttaacaaa 126360
attagcttta attttgtgac aagtaaattt acataaatat aggattatgg agataatatt 126420
tttctttgca atgtctggac cttttataaa cattgagagg aaatataacc attcttactt 126480
atttagtatg ctagcatgat gttttttaat gttttagatc cagttaaaga atatggttgt 126540
gccccatggc ctatggttga gaaattaatt aaacagtgtt tgaaagaaaa tcctcaagaa 126600
aggcctactt ctgcccaggt attcttaaag ttttgttaat attttgtaca gaacatcatt 126660
tgcatatatg catatatata taatcttcaa atatatatac ttaaacacat aaacacacag 126720
agacagaatt aaaaatagtt ataaggcaaa cctcctataa ttttcaccat cccaggcaca 126780
aaaaaaggac attgccaaaa cctcacatgc tcccatatgc ctgtctcctc ttctcttctt 126840
tgaaatgcct gcccattatt ttgcccattt ttctgttgac tcttttgcct acaaatcaaa 126900
tcagaaaaaa atttttatat ataacatact aatcctttct tggttttata tgttgcaatt 126960
tctttttcga gctggtggct tgctttttaa atttcttgta gggtgcccgt taatgaatgg 127020
aatttcttaa ttttaatata tataaattta acaattcttc tttttccttc ttttcctggt 127080
tattcctatt tggtcctgtt gtagagccca tctttctttt agagctacaa aaatatttac 127140
ctgcaatttc ttcaaacatt ttaaaagttt gcttttgaca agattttaat ccattggaat 127200
tgacattttt atctgtatcc cattcctttt tttaatgtgg aagactaatt ttttcaggtt 127260
gatttactaa atggcttctc cccttttgtc ccatagatct gatgtgtcca ttttgtaatt 127320
tattaaagat aatgtgcata tccacgtgta cactgtcttc cactgatcaa ctcatttatt 127380
tttcctccag tattaccctg tcttaattcc tgtagcttta taatgatctc ctctccctat 127440
ttatttttct catccaggaa tattttaacc agtcttaggc ttagcttttc tatataaaat 127500
ttagaatcat gctgtcaaat cttatgaaaa accacattgt cgtttggatt ggtcttggat 127560
tgaatatgtt gacaatctgg agatgatatc cttatgatat taagtctttg tattcttttt 127620
cttatttatt tatttattta gaggcagggt ctcactctgt cacccaggct ggagtgctgg 127680
agtgcagtgg caggatcaca gctcaatgca gctttgacct cctgggctca agtgatcctg 127740
tcgcctcagt ctccatcagc caattgtgtg ccaccagacc tggttaactt ttcctttaat 127800
ttttttgtag agaaagggtc tcactctgtt gcccaggctg gtcttgaact cctggcctca 127860
agcaatcctc ccgcctaggc ctcccaaagt gcatgagcaa ctgcacctgg ccaagtcttc 127920
ctattctgga atggcatgaa ttctctctgt ttacttaggt cttctcaagc gtctttcaat 127980
aaagttttgt aatgctacat acaggtcttg catatctttt gctggatttt cttgctgcaa 128040
attgctttaa atgcagttca tggcttgaga tttgtttttt aactgcccag ttaacgtaaa 128100
tctggtctat gaattgtatt gacaacaagc ttgtgagtag caatttttca gcaacctttt 128160
gctccctctc cccgctccct gcacagtccc agaacaactt tccttatata ccaatgaagg 128220
tggaaatgtg gacaggttga tttctccttc ttgtttatgc tgaatatgca gtcctttggg 128280
gtcccagctt tataggtaca gtccctttac taagactgtc tatcttggga aggccctaga 128340
ctccaacttc tctcccatgg gccccacaaa gcatccaaga gtatacattt atattatctc 128400
actttgtctt ggcagacaaa tgtcttcagg gcaagtctgg ctttaggggt ccactgacct 128460
ctctggtttc tgtctctcac tgtgatttcg gcctgataat tccttatggt gtcagatctt 128520
caatgttttt aatacattgt ttttaaaaaa atcatttagc attttaaatt gtttttagtt 128580
ggaagatttg cccaagtaac cttgtccacc atattatctg aaagagaact cttgtcatgt 128640
tttacactga tacacatttt aataaatgtg ggttatcttt atgttgtgag ctcttgattt 128700
ggtattataa ttaattggaa aagttttaac tttaagtatt ctgatcaaaa tagtcaagta 128760
caactataat gactttatca aatattacat aatttttctt ctacttggtt tacttgtttt 128820
ttaatttagg ttaccatcaa tgttagtcac atgaactttt atatttatgt ccacagtaaa 128880
aatttttcat agcttgttgt ttttctttct tgttttttca ttttcaatta tacttcacct 128940
atacttaaca gaatacttaa caaatatgta tatatatgac aatattaaaa agcttagaca 129000
tacttatttt atgtttaaaa tataacatat actaggcaag acaggaaaac tcatcacttt 129060
tatgaaatga ggcacagaca gagtaatggg ctttcttggt gtctcctgag tggcgggcag 129120
gtggccatgt cacagctcta atcccagttt cctgacttct ggttctgttt tcttacggtg 129180
ccttcacact gtctctccag atcaaaaaca gaatctagag atgacttcta aattttgtta 129240
ccaaagactg aaattcctgt tcctttcaac tactagaagc tcaactaaat tgttggccca 129300
agggtttttc tctcactggc ggtggctctg caatatagaa ttgcatgcag agtacctcct 129360
gactccgcta aaatcctgtt taattgaccc ttgagatttt cttttcaagt taaaaaaaat 129420
actacacata ccaaagagta tcaagcacag tttaaaaata catatttgtc ttttcatgta 129480
attttatttg tagtttagat tactaatctt ggtgatctag ttgggttcca gtttaacagt 129540
tttaggtttt gcttgacaga gctataacac ttcagtctat atttgatttt tcaagggaaa 129600
tgagttaact cgataagtac tgttttgtta tctttaaact ttctcaggtc tttgacattt 129660
tgaattcagc tgaattagtc tgtctgacga gacgcatttt attacctaaa aacgtaattg 129720
ttgaatgcat ggttgctaca catcacaaca gcaggaatgc aagcatttgg ctgggctgtg 129780
ggcacaccga cagaggacag ctctcatttc ttgacttaaa tactgaagga tacacttctg 129840
aggtaaatcc aaatgctctt taaatctttc ataatttaaa gcatatacca tttggaaagt 129900
tacttaggaa taaattaaat aagagccaat gtaggattat tattcaatta gccttctgtt 129960
agaacaagag tattcaagag caaatgtgtt ttgctttaga atcacagcat atgtcttagc 130020
tcagggtccc tagaaacaga gcctgagatg ggttatcttg cacaagtgat ttaaggaaag 130080
agaatcttag agagaagtag aggaagccag aaagggcaga ggaaaaagct cagcagaaat 130140
gtggtttctg aagaggtcca gcctcagtct ctgcccacaa ggagctctgg aatatgaata 130200
ggagcacaga attttcccac tgccaggcaa gggagccagt ctttcattct cacatattgt 130260
tcagtcattg gctgcaatct gctgggaggt gggggtagtg taactttcaa ggcatttctg 130320
ggcaagctgc ctcctgtcat ctgagggtat tctgtgataa atagcacatc tctgaactat 130380
agtagccaac actcagggta gctggggatg gcgtacctga tggataaagg agatctggac 130440
atggctccta aaagtggatc aatacattgt gttggcaaat ataagataag tttctagact 130500
tcaaagacaa cctagtattt tgactgctgc ctgaagataa atattgtgcc tcaacattag 130560
ttctgaggtt aaacaatctt ttttttttaa ttgatcattc ttgggtgttt ctcgcagagg 130620
gggatttggc agggtcatag gacaataatg gagggaaggt cagcagataa acaagtgaac 130680
aaaggtctct ggttttccta ggcagaggac cctgcggcct tccgtagtgt ttgtgtccct 130740
gggtacttga gattagggag tagtgatgac tcttaacgag catgctgcct tcaagcatct 130800
gtttaacaaa gcacatcttg caccgccctt aatccattta accctgagtg gacacagcac 130860
atgtttcaga gagcaccggg ttgggggcaa ggtcatagat caacagcatc ccaaggcaga 130920
agaatttttc ttagtacaga acaaaatgga gtctcctatg tctacttctt tctacacaga 130980
cacagcaaca atctgatttc tgtatctttt ccccacattt cccccttttc tactcgacaa 131040
aaccgccaac gtcatcatgg cctgttctca atgagctgct gggtacacct cccagacggg 131100
gtggcagccg ggcagagggg ctcctcactt cccagaaggg gcggccgggc agaggcgccc 131160
cccacctccc agacggggcg gcggccgggc gggggctgcc ccccacctcc cggatggggt 131220
ggctgcccag cggagacgct cctcacttcc cagacggggc ggctgctggg cggaggggct 131280
cctcacttct ccgacggggc ggctgctggg cggaggggct cctcacttct cagacggggc 131340
agctgccagg caaaggggct cctcacttct cagacggggc ggctgccggg cagagggact 131400
cctcacttct cagacagggc ggccaggcag agatgctcct cacctcccag acagggttgc 131460
ggccgggcat aggctctcct cacatcccag acggggcggc agggcagagg cgctccccac 131520
atctcagaca atgggcggcc gggcagagcc gctcatcact tcctagacgg gatggcggcc 131580
gggaagaggc gctcctcatt tcccagactg ggcagccggg cagagggggc tcctcacatc 131640
ccagacgatg ggcggccagg cagagacgct cctcacttcc cagacggggt ggcggccggg 131700
cagaggctgc aatctcggca ctttgggagg ccaaggcagg cggctgggag gtggaggttg 131760
taggtagcca agatcacgcc actgcactcc agcctgggca actttgagca ctgagtgaac 131820
gagactccgt ctgcaatccc ggcacctcgg gaggccgagg ctggcagatc actcgcggtt 131880
aggagctgga gaccagcccg gccaacacag cgaaaccccg tctccaccaa aaaaatatga 131940
aaaccagtca ggcgtggcgg cgcacgcctg caatggcagg cactctgcag gctgaggcag 132000
gagaatcagg cagggaggtt gcagtgagcc gagatggcag cagtacagcc cagcttcggc 132060
tcggcatcag agggagacgg tggaaagaga gggagaggga gaccatgggg agagggagac 132120
ggagagggag agggagagga acaatcttct tatatggttt gaaggaatga gaattcacac 132180
tgaaaaataa tttttaattt tagtttcaga tgtcatcttg ataggcaaaa cttgtctgcc 132240
aattaactca tttattgctg aaaattaaat aaaattggca ttgtttttaa aagtaatgca 132300
agaaagcaaa aagagttatg ttgataacag aatcctttat tctgtacaag ttctagttgc 132360
ttaagcttaa atcaaatcct gctaagtata ttttcttttc ttaacaggaa gttgctgata 132420
gtagaatatt gtgcttagcc ttggtgcatc ttcctgttga aaaggaaagc tggattgtgt 132480
ctgggacaca gtctggtact ctcctggtca tcaataccga agatgggaaa aagagacata 132540
ccctagaaaa gatgactgat tctgtcactt gtttgtattg caattccttt tccaagcaaa 132600
ggtatggtag tgaatttgat caatggggaa attacagatc ttttaaacga ctgaattgtg 132660
tgcataattg ttattgcatc agcaaagatt gttcattttt agcctatttt cattggtttg 132720
catatattaa agggaattgt ggaaggtcac agagatattt gttgtttttc tgaatacaga 132780
tctagctgag acatttataa aataagtcaa ccatttattc aggcctacca gccctgctcc 132840
tggtattacc tcaactgtgg ctctatctct ttacttctcc tcagatcaat gaatctttgt 132900
agggcctctt caaggataaa ttctcattca ttcattcttt gaaaaaaaaa aaatatatat 132960
atatatatat atgaaaccca ttgtgtgcca ggcttaaaca taccagttat ctaactacca 133020
aattaagaaa aaaattaaat aaatgaatta ataaattctt aataggtgaa aatgacttag 133080
ctcttatcaa ttgcagggtt cttgtcccaa agaaatatat ctacatagca aaatttcagg 133140
tgtgagttgt aggttggtga ctgtaatatt tggggcagga tgatttccag gaggcattaa 133200
gattataccc tatatatttc tctggtttaa gttagtattg gaaaaaaagt actagaaaaa 133260
tgtgaagcct gttttttgta cctgaaatat caactccact ggcagtttcg gagttgaaat 133320
tatttgaata tggtcaaaga aaaatttcaa tggatggaat tgggcaagga cgactttatt 133380
caagcctatc acagcagggg agagagatca gactgaacta aactccactg aaacaaaagg 133440
tgggagagtt ttaagcgcag gggtgagcta atggaaacgt actggagcac cttgttggaa 133500
ggaagtggga gcagttgtca atgtgattag gccatctgtg tttgctaatt gtcccttatt 133560
gaaggtaggc tcctactctc ccacagacac tggggaattc cttccttcct tccatccctc 133620
cctccctccc tccctccctt ccttccttcc ttcttctttt tttttttttt gaaggagttt 133680
tgctcttgtt gcccaagctg gagtgcaatg gcatgatctt ggctcactgc aacttccacc 133740
tcctaagttc aagcgattct ctagcctcag cctcctgagt agctgggatt acaggcgtgc 133800
accaccaaac ctggctaatt ttttacattt ttagtagaaa cgggatttca ccatgttagc 133860
cagactgatc tcaatctcct gacctcaggt gatctgccca ccgcagcctc ccaaagtgct 133920
gggattacaa gtgtgagcca ccacgccagg cctctgtctt gataattaca tttcaaagga 133980
atggctccca ggtccttgga aaagacattc ttggggtata aaactgggaa gagtctggga 134040
aaaggggcag agaaagaatt tataattcca agtcttctaa agtaaatact ctaagaaaag 134100
ggaggttagg aatttatagt tgagaagtct atctaaagtt taataaagtg gaggagaaca 134160
ttaaggccat tttagtcaac atacatgttc tttttgtaac aatttcaaca tttttccttt 134220
tagcaaacaa aaaaattttc ttttggttgg aaccgctgat ggcaagttag caatttttga 134280
agataagact gttaaggtaa atgttgaatg cattctacat ctaaatttat tttaagtctt 134340
ttgttttata tatatctcac acccctctta tgggattata aactccctga gagcaagaat 134400
cataaattat gctgtatttg tattgcttca taaaatcttg aacacagtag atcctctgaa 134460
aatacttgct gattgactgt atattttata tgaatgaact aagaataaaa tgataaatga 134520
catctgattg ataatattgg gaatggaaat aattcaattt gtacataact gaggcagata 134580
attccttata aatatattgt ggaaaaaaaa caaaaatata cttaagtttt aaatatggct 134640
tgccattaac tttttcttaa gcattgaaga aatcatttaa ttttcttttc ttcagattcc 134700
tatttagtca ttaaagcatt catttctcta tccatctatt catctttggt tccatctatt 134760
cactcaactt cctacccgtt cattctccta ttgccaaaaa gcttattatc tgatgagaga 134820
cagggaagta gagtataacc cttaggttat ttcttttgta atttttacat gggaaaaaga 134880
atagattgaa tgtaacaata atatttcgaa tatgacctaa atttttttat gtataatatt 134940
tgtacatatt tatggggtac atgtgatatg ttgttacatg catagaatgt gtaatgatca 135000
agtcagggta tttaggatat ccatcaccat gagcatttat ttctctgtgc tgagaacatt 135060
tcaagtctcc tagttatttt gaaatgtttt taactgtagt cactttattg tactattgaa 135120
cattagaact tattcctcct atctaactgt atgtttgtac ccgttaacca gcctcccttc 135180
atcctcccct tctcccacac acccatatcc tcccaagcct ctggtaacta tcattctact 135240
ctctacctcc atgagatcaa cttttttagc tcccacatat gagtgagtac atgtgatatt 135300
tgtctttctg tgcttggctt atttcactta acataatgac ctccagttcc atccatgttg 135360
ctgtatatga catgatttca ttccttttta tggtcaaata gtattccgtt atgtaaatac 135420
acacattttc tttatgcatt cattcattca tgggtgctta ggttgattcc actttttttt 135480
ttagctattg tgaatagtgc tgcgataaac atggggatat aggaatccct ttgatatact 135540
gattcccttt cctttagatt agtatcagta gtaacattgt tggattgtat ggtagttcta 135600
tttttaattt ttttgagaaa tcaccatttt gttttccgta gtggctatag caatttacat 135660
acacaccaat agcatatggg cattcgtttt tttccgcatc cttgccagca tgttattttt 135720
tgtctttttt ataatagcca ttctaattgg gtgaagaaga tttcattgtg gttttcattt 135780
gcatttttac tgatgattag ttaatgttga gcattttttt tcatatatcc attggccatt 135840
actatgtctt cttttgcaaa tgtctattta gatcctttgc caactttttg ttttgtttta 135900
agacagggtc ttgctttctt acccaggctg gctcacagtg gcatgatcat agcttgttgc 135960
agccttgacc ttctgcactc aagtgatcct ccaacatcag cttcacgagt agctgggact 136020
acaggcgtgt gctaccatac ctggctgttt attttttgta gagatgcggc tccactatgt 136080
tgtccagact gatctcaaac tcctgggctc aagcaatcct cctgcctcat cttctcaaag 136140
tgctgggatt acaggcatga gccaccatac ccagcccttt gcctactttt aaatggagtt 136200
cttttttttt tttcctgttg aattgctttt tcgagtttct tgtgtattct ggatgaatag 136260
tttgcaaata tttcctcaca tttaatggat cctctctata ttgttgatag tttcctttgc 136320
tgtgcagaag ctttttagtt tattatagtc ccatttgtct aattttgttt ttgttgcctg 136380
tgcttttggg atcttaacca taaactcttt gtctagacca atgttctgaa atgtttcccc 136440
tgtttccttt taatagtttc atagcttctg gtcttacatt taagtcttta atccatcttg 136500
agttgaattt tgtaaatggt gagagagtgg ggcctacttt catccttctg catactgata 136560
tccagctttt ccagcacaat ttattgaagg tggtattctt tctcccatgt atgcttttgg 136620
tgcctttgtt gaaaattagt tggctttaaa tatgtgggtt tatttctggg tcctctacat 136680
tggtctacct acctgtgttt ttgccaatac tgtgctgttt tggttactct agccttgtaa 136740
tatattttca agtcaggtag tgtgatgcct ccagctttgt tctttttgct caggattgtt 136800
ttggctattt tggctctttt tcggttccac tcaagtttta gaaatttttt tttctatttc 136860
tgtgagaaat atcattggag ctttcatggg aatttcattg aatctgtaga ttgctttggg 136920
tagtatggtc attttaacaa tattaattct tccagtctgt gagcatgaat atctttccat 136980
ttgtttgtgt cctcttcaat ttctttcatg tttttcaggt ttccttatag agatcgttca 137040
tcatctttgt taaatttact cctaggtatt ttattaattt tttgtagcta cttcaaatgg 137100
gattgctttc ttgatttttc agctactttg ttgttgttgt tgtatagata tgctactgat 137160
ttctgtatgt tgattttgaa tcctttacta tactcattta tcagaactaa gagttttttt 137220
taatggaatc tttaggtttt tgagttttaa ttttaatatc tctaatcatt taagatggaa 137280
agtagttttt tgaaagcaca gattttatgg agttttgttc tgtggatact caatttgctg 137340
agtgtgtttt cttttttttt tggcaaagct taaaggagct gctcctttga agatactaaa 137400
tataggaaat gtcagtactc cattgatgtg tttgagtgaa tccacaaatt caacggaaag 137460
aaatgtaatg tggggaggat gtggcacaaa gattttctcc ttttctaatg atttcaccat 137520
tcagaaactc attgagacaa gaacaagcca actgtaagtt attttttatc tgtacaagta 137580
atttatcatt atacttttgt tttttcctta taatcattaa taatactgtt gataattcat 137640
aaggaagatc ttttaaaatg cataatttat tttctatcat aaaattaaac tttcattata 137700
aaaaattttg aaaattccag aaagcagaag ggtattttta agaagtcact caacctaatc 137760
acttttaggg ataaaatatg taaactcatt gtaatcttag tagtatttat caatctaaat 137820
tttttaacaa tttttattat ctgtgtttca aattagacat gaaattggaa gacaatcaac 137880
tttgtatttc accaaattca cggactatac atatgcaatt tgggtaactt ccattaagta 137940
ttgattgtag gaaagataga cagcaagtat tcttgcttgt ccaaagttgt ttctagattt 138000
gataattata cagatgtcta ctcacagcca agttagtgat accagtttca aacaagaata 138060
aaataaaata ttaatataaa cctctttcaa gtttgctttt tttcagtggt attttaatca 138120
aatctttgca gttggttctt atttatcaca ttcctcagtg ataagcagta taggattgtg 138180
gataagagca taaatcatag ttcagatatt gctttgccat ctattggttt tgtgaacttg 138240
ggcaataacc tttcacatct tcagtcatct cttacctgag gattgtaata ttctctatct 138300
caaagagata tttggaggag taaataagaa tgttaatata tggatcttaa ttaacataat 138360
gaccagcacc tggtaagctg tcaataaaca ttagctatta ttattattat tagctttgag 138420
tcacaaatcc ctaccttagg gaatatcctg gtttcccatt atccatcaaa tttcccaaga 138480
ttggcacttg ggagtaatct ttgactcctt tgttttttgc tccctttatc cacttgaccc 138540
tcctaattgt catttgaatc tttgtacttc tcactgttct cagtgctggt accatgggcc 138600
agactgccat ccattatctg tggccacatt aacaagagca tccagttctc accctctgat 138660
tatactctct tcaacatatt ttcagcattg cagacagagg gacctttcta aaatgtacat 138720
caatctgatg caattttcct gcttaaaacc cttcagtggt atcccattgt cctttatatg 138780
aagtccaaat tccttaagac agcctactgg gcccttcata attcagtgct tgcttacctg 138840
tctagattca tattttgcaa gctttttgcc atctgtgctt tacccaaact gaaattgact 138900
cagatctcta agacaacctg ttattacctt tcacccccaa cctttgaatg tggtcttctc 138960
cttacctgga tgactattat gccccctgcc tatttcagtc caagcaccac ttgctctgag 139020
tggcaggtta ggtgactttg tgcttccatt gcatctaatg ttttccttca cagtagctat 139080
aattgtattt gttaaagtag tttctcaata ccactaaatc tactggcttt caacattggc 139140
tgtgcattta gaaaccacta ggtagctgaa aataatatga tacctgggcc ctacctcaga 139200
ccaattaaat cagaccagtt aagcctggga tggggatcag attttttttt tcaggttctc 139260
aagtgattct aaagtatatt tgaggttaag atatactgcg gagtgcagtg tattataagt 139320
tcccatgaat gaggattttt atttctgtct ttacatattt atttactagt atgtggttaa 139380
catttggatc aactcattct cattctgtaa tacccacatt ttaaaaaatg aatgtaaaaa 139440
tgtcttttat tatttttatt tttcaaattt aattttagat tccaggaata catgtgcagg 139500
tttgttacaa aagtatagtg cgtgatgctg aggtttggaa tacaactgaa ctcacaaccc 139560
agaaagtggg catagtgctt gataggtagt ttttcatctt tgctcccctt cctgtaattt 139620
ccacttttaa cccaattata caagcctgaa aacctttaaa aagaaagggc ctccagttta 139680
tttttttatt tcatagcaca ttttatggga ttatggatat cagttaactc tttaaagttc 139740
catataagat ttggagcata gatgctttac tagagagcat ccataaagat caagctctca 139800
aagatgctca tctcccaaaa gagattggga cctagatgca taaacactta aatataaata 139860
tttgctctct tctgaacaag tatctcctgt ggccttggtc tctaccccac aaaacagaca 139920
tcacatcact aatcaggggt tgcctcatca tcagtaccct catcatcatc agtacacacc 139980
gactgagagg catgttgggt aatgaaagat gactgccttt gaagccggaa gactccatag 140040
gacttttgga gttctaggtc tgcaacatgt ttttagtcct aggtcggcaa gcatgatgtt 140100
agtcatagga ccttgagcaa attatttagc atttgtacat gtttctttct actattaaaa 140160
acattgagat ttatcatatt ttatgttttt ttattaagga tcaagcaaga taacacacaa 140220
aagtatttta taaaatacgg aaattccatg caaaactttg tcctaattgg aactattttc 140280
tattaaatac agcaaatatc caagaaggaa ttacctaaag cgtagtggct ctctgacaac 140340
acatcatatt tttacctcct tttccagaat agaaagaaaa gggggaggaa aaaaaatctt 140400
cctactctag gatatactaa tgattgttaa atctttatgg tattttcatg ttatctatct 140460
gatttaaatg caattttgac tatttttaca tattcctcgt tgttcattca tactgtagtg 140520
ccttcttcta ttcccccact taacagactg cttgattata tcagaggtgc ttatctgtgc 140580
aactgtttac tggacgaggg gtatgtagaa aatacattgt cctcatcctt atgaaattac 140640
actcataatc tagtgtgagg gatgcactaa taaagacaat tttatattta ataaggtcta 140700
taatatgaca gtgacaccag tggggaaaag ggactggttg gtctattttg ataggtcagg 140760
gaagaaatcc agaggagccg acatttaagt tcatcctcaa aggccaagta ggagtttgcc 140820
atgctgatgt ggcccaaggt agccaatctg tttgtgaaat atgtacaatg ccagatgtct 140880
taggttgaaa gggaaatatt ttaaggtgtt cgtaattttt ctttatgttt aaaaggggaa 140940
aatggcaaat attttacttt ctgtttatgt ttggatgatg tggatttttg ttttctataa 141000
tttgactggc ttaactgcaa agatatccct tgctttaaaa tttgaagaca ctgcaactaa 141060
attttatttc agcattttat attttataac tctaggtata aaaggctaac acttaatttt 141120
ctgagcattc atgaaacaaa gttttgcaag aacattcaaa agttacagat ataatatttc 141180
cttcagaaat ttagatatag tacaaaattc tacaaagagc cacatagaat tgaaactaaa 141240
agtaagacca aagtaaacat tggacataat ctttatttta ttatcacaag aaattaatat 141300
aaagtaacca aaagtaagta aagtaccaaa gcatgttata tattcaattc agaatggtta 141360
gggaagaata tgaaataatt gcaatagtct agcttgttta gttttcaaaa tagtgttttt 141420
acattaagaa ctaatataag gttgtattac acgtagaaat tttaagaaga aaacaaatag 141480
tgatgacttt ctattttttt ttctctgtag gttttcttat gcagctttca gtgattccaa 141540
catcataaca gtggtggtag acactgctct ctatattgct aagcaaaata gccctgttgt 141600
ggaagtgtgg gataagaaaa ctgaaaaact ctgtggacta atagactgcg tgcacttttt 141660
aaggtaaatt ctgtggtttt taattttatt cccaaaagaa ttatctttgc acttcatgtg 141720
tcacagagga aggatttttc ttcctttctg cctctgaata gagaattttt ttaaaatgca 141780
gaaaaaaatt tgtaatgctt ctcagcacca tcttttcaga tcaagaaaat tttgtcttca 141840
gaacataaaa gaataggcac ataatgtgca tagttttctc atggtattac aaagaatgtt 141900
ctcgaatgaa aatactacat tattgaaaat gagcatattg gagtctctgc tagctttgac 141960
atagttctgt cacagtgtca aatatactat ttataattaa attatgggcc ccaggattat 142020
ctgctctaaa gaaaaagagt cacaaaataa tagacaaata tggggggaaa tgcaatggac 142080
tgaccgaggc gctaaggagt ggggatcaag accccagaat gagagcatag tgcttagtct 142140
gatgcagcct gtgagtgaca aatccatagc aagcacattc tttctgtgct ggtgctgaga 142200
aacaggacca ttttcaagct tatttgctag ccactttata tttttatttt gttttgattt 142260
taccatatag atctatgata ctcttgagaa cattttagat tacacactat atctgtaaaa 142320
ggatacttca aagtttcctg tcttagattc atctgacagt ttttctatgg attgtgagaa 142380
gggctcacag tttatgttca gaagggccaa caggtctcct tgataaaggg ttccttactt 142440
cctgaagtac caaaacgatt aggattcttt tatttctgga cacttcattt ttgtcatgaa 142500
ttagactatt cactggttct gggaaaaaat tcagtggttt gtatcgatat cttttacatg 142560
tgaatgacta taattttatg ttcctttgta acattgagac ttcatgtaaa acttttgact 142620
ctaacttttt tttttcttta tcctgggcac atgtatgcta tttttactga attagatagc 142680
tttggtattt ataaaaattg tatccctctt attcataatt tcctgaaaat gaagggctat 142740
tgttatcttt gataatttat gcttcaagta aagaagtgtg gctctttggc atctgtattt 142800
agcaaaattt gctttgtata attttaatga tgcataatgg tggtggtgtc atgttttaat 142860
aatttaaaat gttgtttatg ttatcatatg taaatagcat ttatctctta attggtggta 142920
aaattattaa tgtatacttt atggttctag ggaggtaatg gtaaaagaaa acaaggaatc 142980
aaaacacaaa atgtcttatt ctgggagagt gaaaaccctc tgccttcaga agaacactgc 143040
tctttggata ggaactggag gaggccatat tttactcctg gatctttcaa ctcgtcgact 143100
tatacgtgta atttacaact tttgtaattc ggtcagagtc atgatgacag cacagctagg 143160
caagtttctt tcctttagat atttttcata ttctctaagt cttataaaat atgcctttat 143220
tttacgttta cattttctct gaactttcca gtgtcatatg gatggtcttg gagggtcaca 143280
cagtgaaaca taagactggt ataaattgtg aatagggtca ttacagaagt ggagggagta 143340
aatgctctca gtcccacaag agaagcagat tactgcagct gaacactcag tttgggtctt 143400
acttgctttt ttccttttta cctaaggcaa aaatgggaaa tacatggtat tgaatatatt 143460
ttactttttg agcaaagaaa ataaagaaaa tgtttgtttt aatcatagtc tagcctccca 143520
gcttgttaaa gaatctcatt tggtttttca ttctataaca aatctttttt cttgcagcaa 143580
tacatgctga actgcacaac ctacaaatat tgacaaatca tattttactc aaactttgtc 143640
tttttttgct tctattttta tatttaaata tgataaaatt gtgatagcac ataaaatata 143700
ttttctgcat aaatatattt gcgtcttcct ttgataataa tttgttttag aaaataacaa 143760
taatagcata tatacaaaag tttacaaaaa cgacactatg gggtttaatt ctgaaaaaaa 143820
ctagaattta tgtaacttta gcaaataatg aatgttttga acatggtgaa gaaaatatat 143880
tcattgcaag tatatgtgaa agaggaacat gtgtttttct agcaccttca cctatttttc 143940
atttatagac tttagagttg cacaggagtt acaattagat gctcttaatg actgtaaact 144000
attaagatac atgtccacac aagcagagca gtaggtctct caataggttg tctcagtagt 144060
cttattctac caaagttgtt gcattctcta gttgaattgt atgtactttg ggacccaaat 144120
agcttgctta taactgaagt tatagtggaa tgtctatggg ttatagtttg attttaaaat 144180
aaagatcaat tggaggatag cctacaaggt gctgcatgag ctggcttcac tgtacctctc 144240
ctgcctccat catctaccac attcctacca gatcttgctt gtctagatga acatccagtt 144300
cttctcaatt actatgctat attttgcctc agggatttgc acatgctgtt tatttctttg 144360
cttagttaac atagcttttt ttcatgctta tttaactcat atgctttgaa atgttagctc 144420
ctgtgtcaaa acctctgaga agccaacact gattaggtca aagttcccgc tttgggttcc 144480
cataacagct ttcttgcata gttttgatca tggtcatatt tttttttcat taatgctagt 144540
ctcttcacta gaatataaac tccaagacgg ttgggttagt gtgtttttgt ttaccccttt 144600
tttcccagga tctagcctag ggcctacata gaagactttt gatgcaaatt tgttgaataa 144660
attagtgaat gatttgaaaa gaaaatatga tattttgaca tagtatcagt atatccatcc 144720
atctaagtgt ccatctaaat actcatattt gtactaaata ctcatatttg taccttacca 144780
tatccaaaga acttttcaca cacattacct cgtttaacat tgtaactttg ggaagggtaa 144840
tgtataaata ctgagcctat tttatagaaa ggttaagctg ttttctcaga ctcacataat 144900
taagaattgc agcaaggagt ggatcacaga ttttgttatt ttttaaaaaa atgctggtct 144960
ttattcaata taattgaagg gtcacctaga aaatagaatt gtgaattcag ttccaaggta 145020
tttgtgtctt aaactatgaa caactttact tttttttcag gccagtttaa tatatagttt 145080
taacagaaaa cttacatatt ttgtttttgt aaaggaagcc ttaaaaatgt catgctggta 145140
ttgggctaca accggaaaaa tactgaaggt acacaaaagc agaaaggtaa catttagaag 145200
gatactgttt tccaaacagg gcaatgatgt gaatgatggt aacatattat gtgtttcata 145260
aatttgtaga aaatattaca tatggtataa tcaggaattt taattggtag tttatagtgt 145320
aaagaactta gacataaatt ttcaaaatta caagtgatat gaagtgttaa atatttatat 145380
tttcagctga agtagaggtg tcaatcacta gctcaacctt aaacgaaatg tgaatatttt 145440
ttacaactta tctatatcta cataatgtct aattttgaac agtgtttgaa aaagctttta 145500
tttcttttag aatatgaaat gttaatttat taaatgttga tactctattt gaaatttaat 145560
agtttctata atgtattata aaacttttcc aagtatagtt ttttataaat aataatttag 145620
tacattagtt atagctgtgt ttatatttac atttatctaa gtcaactaaa aatacatgag 145680
ccaaactgaa ataaaataag aatgttttat gatggatctt tgaaacatga tttcattttt 145740
ttctttttct agagatacaa tcttgcttga ccgtttggga catcaatctt ccacatgaag 145800
tgcaaaattt agaaaaacac attgaagtga gaaaagaatt agctgaaaaa atgagacgaa 145860
catctgttga gtaagagaga aataggaatt gtctttggat aggaaaatta ttctctcctc 145920
ttgtaaatat ttattttaaa aatgttcaca tggaaagggt actcacattt tttgaaatag 145980
ctcgtgtgta tgaaggaatg ttattatttt taatttaaat atatgtaaaa atacttacca 146040
gtaaatgtgt attttaaaga actatttaaa acacaatgtt atatttctta taaataccag 146100
ttactttcgt tcattaatta atgaaaataa atctgtgaag tacctaattt aagtactcat 146160
actaaaattt ataaggccga taattttttg ttttcttgtc tgtaatggag gtaaacttta 146220
ttttaaattc tgtgcttaag acaggactat tgcttgtcga tttttctaga aatctgcacg 146280
gtataatgaa aatattaaga cagtttccca tgtaatgtat tccttcttag attgcatcga 146340
aatgcactat catatatgct tgtaaatatt caaatgaatt tgcactaata aagtcctttg 146400
ttggtatgtg aattctcttt gttgctgttg caaacagtgc atcttacaca acttcactca 146460
attcaaaaga aaactccatt aaaagtacta atgaaaaaac atgacatact gtcaaagtcc 146520
tcatatctag gaaagacaca gaaactctct ttgtcacaga aactctctgt gtctttccta 146580
gacataatag agttgttttt caactctatg tttgaatgtg gataccctga attttgtata 146640
attagtgtaa atacagtgtt cagtccttca agtgatattt ttattttttt attcatacca 146700
ctagctactt gttttctaat ctgcttcatt ctaatgctta tattcatctt ttccctaaat 146760
ttgtgatgct gcagatccta catcattcag atagaaacct tttttttttt cagaattata 146820
gaattccaca gctcctacca agaccatgag gataaatatc taacactttt cagttgctga 146880
aggagaaagg agctttagtt atgatggata aaaatatctg ccaccctagg cttccaaatt 146940
atacttaaat tgtttacata gcttaccaca ataggagtat cagggccaaa tacctatgta 147000
ataatttgag gtcatttctg ctttaggaaa agtactttcg gtaaattctt tggccctgac 147060
cagtattcat tatttcagat aattccctgt gataggacaa ctagtacatt taatattctc 147120
agaacttatg gcattttact atgtgaaaac tttaaattta tttatattaa gggtaatcaa 147180
attcttaaag atgaaagatt ttctgtattt taaaggaagc tatgctttaa cttgttatgt 147240
aattaacaaa aaaatcatat ataatagagc tctttgttcc agtgttatct ctttcattgt 147300
tactttgtat ttgcaatttt ttttaccaaa gacaaattaa aaaaatgaat accatattta 147360
aatggaataa taaaggtttt ttaaaaactt taaatgcttt taagcatgtt tatgaatttt 147420
taaactttgt gatagtgttt tgcttttcac atataggtct gttatccatc tcataggaaa 147480
ctttgtatta atttgtatat gggacattcc acaataagaa agtgcaacta aagttttttc 147540
cttgataact tatggaatat ttaaatttaa ttttctataa tacatatagt tgccaggatc 147600
ccaggacaaa atctgatggg catgatacat tctattttca agttctctta aaaagttttt 147660
gtaagtaaac ttgtttgctc ttgagtactg aaacaaaata taagacttta gagcaaatga 147720
catatacaaa aaaaaggcac agtcacttca actgttttct gattagaagc ctaaaataac 147780
ttgctaatta tgatcaaaat acaagcatat tatcgtaaca aaatattctt ttgggaaaat 147840
tttgaattaa gaaaagggag cctctttgac tctaattctg gtaggtactc tatcgattat 147900
gtgtgaacta tttcaactaa aacgcaactt atttttcatc aaggcagtga aatatattga 147960
tgaaacatag cagaattacc aaaaaaagat tgtcaatttt cctaagttaa atgtaaggat 148020
gcaaatgttc taatattgag gggagataaa attcaaaacc attgggactt tgcttcttta 148080
tccatcactt tgggtagctg aacacctaac ctggtaaatt gaatgttttt catggaggct 148140
tatcagcaat tcagtaaaat agtaaactat gtcaactcgg gagaaactga catcctcatt 148200
ctccatgcta gccagtttct catccagggt gtcattgttt ctaataacaa ttcagaatct 148260
ggctgcttaa aggcacctac gtacgtggtt ctttctaatt tgtcaaggca tttggagtga 148320
tcctatcacc ctgatttcaa gcaaaagaca gggaggcacc tgacccaaag gcctgctgtc 148380
tgaacacact ctgaatgggt gagcagagat gtgctttaag atagaaccta aggtggttct 148440
ctctatgtgc tgccctcaca ctgctcttga tttctaccct tacctgggaa gtctctactt 148500
gatgtctgtc ttaggctaag aaaaagagaa gagaaaggga atgagtatta gcatctggat 148560
tctggggctg cttcttggcc tctgtgagaa tccactgttt cacagcaatc acagcctaga 148620
aaactagact ttatggagta aacaataggt atcattctga cctgggcttc accacaatca 148680
cccactgaac actcccaaga gaaggttgtt accatttatt tatgaaaata ccaaactatg 148740
tgatacatac tctattagaa gtattatgga aaaatagaga atatgtctac ctggccagag 148800
aatagaggat ctggatcaca aaaaaagtac aaatatttaa gcagagactt aggacaaatg 148860
ggcattcaac aatttaggac acatgggcat tctacaattt ccagagtgaa gtaaacattc 148920
taggcagata aatcacacat gtgctgtctt aggaatgtga gcttattttg aaagcatccc 148980
tatcaaatac gtgctaaaac ttgtgacaag ttcccattcc tagagtactt acaggataca 149040
cttaagtgac tgaagatgca agagaaatat atatttgtgt atggatatag cattttatca 149100
ttaattgaga gattataaag ctaatgagct tttctttgca gagggagtat ttgttaggat 149160
gaaatgggga gagatgtttc aaacaccaag tttatcttat aggttaagaa atcctagaag 149220
gaatccatga ctttatgtat atatacaata tatgacaaga gatttcccca tctcattaca 149280
aaatgagcac aaagtaacta actcaaagct tttgctatta tgataaaagt ttaaaaggct 149340
agtacatagc agaaatgtga tttactataa cgggggtcca ggggataaaa tatttgcaag 149400
ctgattgtct catgttggca atgttttcat ttcctactac gttaggtaac acagatgaga 149460
ttgtacatca gagtaagaag gcaaccacta atagaagctg catgcgggca aaagactatt 149520
ctctgaccat aagcttagtt tagatggatc cttgctgcaa tcactaaatt cataaatctg 149580
tgctagtatt ggatcaggaa atctctgcac aagcagataa ataaaaactt tctgctttgg 149640
ctgaaataac tgcttttagg aaaagaaaga gtatatgctt attaatatag cttgggatgt 149700
ggacctcttt gacgagacta tacaattcaa ggtagacaaa gtatgcctaa aaataaatct 149760
aaaataaact tgtatattca aatggaacat attctttaat aatgtcattt ttaagggctc 149820
tgcatttatt ccataaatgc tgccattatt gttcagtttt tcttaattac ctgcattcac 149880
tttagaaaac agaaaaaaaa aaaaaaaaaa aaaaaacaga aacagttgca aaagaaagca 149940
gccagaaaga acatacattt agaattgaaa aagaccttgg tctaaattct agatttggca 150000
t 150001
<210> 3
<211> 149001
<212> DNA
<213> Macaca mulatta
<220>
<221> misc_feature
<222> (13141)..(13231)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (32848)..(32867)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (76156)..(76175)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (90592)..(90814)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (120751)..(125689)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (127650)..(133006)
<223> n is a, c, g, or t
<400> 3
tcttgttttt atgttttctt attcaagatt atataactat taatttatat tttatttttg 60
aagttatttt tatttaactt tttaatctat ctggagtttg ttttgatgtt tgctgtaatt 120
agaaatgcca gtattatttt tttcttttca ggaagttagc caaatgttct agcaccattt 180
tattctccac tgagcactgc ttccatcata aatttgtgcc tgtaatcttc attttcagtc 240
ttgttaacta cctgaagagt tgataaatct tggaatttta gtcagtcaat taaacatttt 300
tgaaacctaa gagaatactt taccttaaca ctgcagtagt tcatgggaga atgctcccaa 360
cagataattc atattttcat actgcctact cacagtctgg ccaatataga gtagataata 420
aataggcaat agatggatga atgaattgtg gaaattggag acatcttttt tttttttttt 480
ttttgagacg gagtctcgct ctgccgccca ggctggagtg cagtggccgg atctcagctc 540
actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc cgagtagtta 600
ggactatagg cgcccgccac cgcgcccggc tagttttttg tattttttag tagagacggg 660
gtttcaccgt gttagccagg atggtctgga tctcctgacc tggtgatccg cccgtctcgg 720
cctcccaaag tgctgggatt acaggcttga gtcaccgcgc ccggccggag acatctttta 780
atttagattt attttgcttt ggaagggagg taggttttaa tttcttgcaa ggttgtaatt 840
cagtagaata ggaagggaga aactaatgca gaggaacaga aggaatgcat gagatcgaga 900
atgcctagaa atatttgaga cattgattaa gtcatcagaa atggaaacaa gtttagaaac 960
aacttagaaa agaatacact gtaggtctga taaatattgt taagattagg attttttttt 1020
ttaaattatg gaaaatgtta tacagacaga atagtagaac agaccacatg aacccatctc 1080
ttattatctt caacaattac cagttcaaaa attgttattg ttatctctgc ctccacacat 1140
ttcatctttt cctccaccac tggatgactt tgaaacacat cctaaccctg ctaccatttc 1200
aactgtaaat atttcagcat gtctctgtaa aaactgaaga ctctacaaca acaagacata 1260
gacctaatat ccaggttaag taggaatttg ttatcttact aatctgatga aaaaacaaag 1320
tctagagcat ttttattaaa gtggtagagc atgaagaacc atctaccggg tgttaggaga 1380
tttgcctgag ttgaagtcct ggctctcaac ttcccacctg tgtgactcca gcaaagctct 1440
tcacttctct actccaaatc tcaatttcct cattagtgaa agaaggatac atagtagtag 1500
ttttatccat ttcagacttg tcatcaggat tgaagtaaca gatgtgaaaa caaatctaaa 1560
attgtgaagt agtaacttcc agtccaatcc tcttcttttt aaataacctt gaggacagac 1620
acatcaactg aaggatagat catctttgcc tagccttgtt tacaatgttc ttgctaggtt 1680
tctcttccta aaaacacatt acttaggtac ttaacagaac aaacaatcaa aaaacgaaac 1740
caaaaaactt tggggttata gacacccata ctcataagta attctgaatg ccaagagaag 1800
agtatttcgg tttgcttctc tcaccttttc acctttcatt tcatgtaccc tgtcctttgt 1860
ctcagttcta atagctctga gagctgatta cttttccggt gtcccacgta tcaggatcct 1920
gcctagtgca actcaattcc aaaagttaat ttagtggcct tttggtgacc agagcttcag 1980
ataactcaca gggaaacaat gtttatttcc tctcccacta acagtcacaa caataataaa 2040
aaagacagta gcggggcaag ttttgatggc taacctctct ctccatcctt taaggggaga 2100
actctataaa gagaatgttt tcctaaaggg gccatctggg cggtgtcctc tttttcccag 2160
cgccctgatt tctattctta gatctggaga taggcggctt tcatttttcc tgctgccagt 2220
tcccagacct tccctggggc cgcaggatcc ccggctggcg ggtcgaggag ggtggccggc 2280
cgggctgcgc actgcgcgcc tccgctgcgg ggctccgggc cttgggactc ggcggagtcc 2340
gctgagtcag tttcttcctg cgcgactccc cgccgcgccg ccgctgtggt ggaatctggt 2400
cccaggaggc ggcgtccgcc cgggtccagt ctaggcgtgc gtgggggcca cgggcacggt 2460
catcccggcc aggcccggct ccagcagccc cacggccgcc gccgaagttc tgcgcggccc 2520
gtcgccccgg cggagcctct ggcaggcccc tgagctggtt ttttggggcc tggctggggg 2580
aggaggaagc cgagcaggag ggctctggag agggagggca acgcggggcg gggagccacc 2640
gccttcctca taaacaggcg ggcgtgggcg ccgacggggc ccccggggag ccctggctga 2700
gggcggtgag ctgagctaga tcccggggag ctgtggccgg cgcccctgcc ggttccctga 2760
gcagcggacg ttcgtgctgg gagggcggcg ggttggaagc aggggccacc atggctagtg 2820
gcagctgtca ggggtgcgag gaggacgagg aaactctgaa gaagttgata gtcaggctga 2880
acaatgtcca ggaaggtaaa cagatagaaa cgctggtcca aatcctggag gatctgctgg 2940
tgttcacgta ctccgagcac ggtaatcact tgcgaagaaa ctgtgctttt gtttttgcaa 3000
actttcgccc cctcctcaca tttgcaaact ttgtcctcct ccgctgacgc tgctcaaacc 3060
cggactctta aagagccgta aactcccatc tcctttcctt agggcggaaa ggagctgaga 3120
attccaggaa ggtcttcacc tttttgactt ttctcccctt ttcagactta aaaggaaagg 3180
gggtgctgtg gattgtgact ttgcttcttt tccccaccca cttgttttcc agcctccaag 3240
ttatttcaag gcaaaaatat ccatgtgcct ctgttgatcg tcttggactc gtatatgaga 3300
gtcgcgagtg tgcagcaggt aaaggcattg ttttcacttc aactcattcg cccttctgtt 3360
tggaaggaga cgttttactg gcagtgttat atagccggga gttcttggtt attctggaaa 3420
tttggcttga ggaacctccg actgtgattt tcagatgggg acattgttaa atattttgat 3480
catgtaaaaa gggatgaagg gccccagtat gtgttccctg agtgtcttta agtagtaact 3540
ttataaaacc gacagtatgg gtggtggtag aagggggata aaaatgggtt cgggtttagt 3600
cccgttattg gcaagatgaa ttaattactg tttagacctg actattccag gaatcttccc 3660
aatgtagaac atgtcctaga tgagaggatt atgagtagtt tggaaaaggg gaataactaa 3720
tagtgataaa atgccacttt gtcactggca aactcttgta gagttcagca tttcttaaaa 3780
ttcaaagaca gatttctagc ctttagtttt agtatacctt gtagtatcta aagaaagtca 3840
tgtcttttga gaccctcata atttacaact gttgtcgtat aaaatgcatg taaaactgaa 3900
acttttacaa tctgtaccac aggaaaccca gaaatttgct aaataccttg gatatatatt 3960
tttttaaggg gggctttaaa atggtaatta agaatgattt acagtcaaaa caaaattata 4020
ggccaaagtg ataacttcct ttggagtact tagagatttg gggaactgaa atcagttttg 4080
tcatctgcat gttaactcat gcaaagaaag agaactggac tttgaactcc atggaggtgc 4140
agtcagaaag ccaatgtttc ttaatacttg agaggcttga cagaggtaag gcatctcaat 4200
ctttaaattg gtgtgggtct atctttatct ttatgcttat ctctgtatct agctctatct 4260
gtctgggtga accatctagc ttctttcata tgaggacatt tatatctgga agaaatattt 4320
taatttgttt tcaactgtga aatattttcc atctgactgt tacagatttt cacaccacta 4380
tcaaaccaaa ccaagaaaag atggaggcat aataaagatg ctgttctttt aagactcaaa 4440
gtcggaattt tgcctgtgga atatgagtca ctctttgggc aatggcctat tgtgcttcct 4500
gctctgcacc cacgtcatcc cttcttgcct ctgctttggt gttcggaagt gcctggttct 4560
ggccactttc attccctaga ctctgtactt catagagtca cttctgcttg ataccgctca 4620
ggacagtcag accctaggta ggctttggtc tgcaaggtct agataaggga gtgctagact 4680
tgagaaccca agggactctg gaacatacca cctaattctt aattttagaa attgcacaag 4740
cctgagcata cttgtctgga gtagttatga gtgtgtcact cagtatttct gcccagagga 4800
tactggaggc aaagtatgct ggaaaataag gaagagtctt tttataagta attaattact 4860
tttttggatg tatcatagtt gtatatgttt ttggggtaca tgtgatatta gatacatgta 4920
tacaatgtgt aatgttcaaa tcagggtaac tggactatcc atcaccttga acatttttct 4980
ttgtgttggc aacattacaa ttcctttctt ctagttattt tgaaatatgc aataaattca 5040
taatttccct actgtactat taaatacgaa cttaattgct tctatctaat tatatttttg 5100
tacccattaa ctaccttctc tttatccctc cccatccttt cattcccagt ctctggtaac 5160
caccattcta ctctctccct ccatgagatc caccttttgg ctcctacgta taagtgagaa 5220
tatgcaatat tttatttctg tgcctggctt attaaattta acataatgac ctctatttcc 5280
acccaggctg ttgcaaatga caggatttca ttttttatga ctgaataata ttccattgtg 5340
tatgtatgcc acattttctt ttatttttag ttaagtaatt aatttagaga cagggtctca 5400
ctctgttgcc caggctggag aacagtggtg tgatcaaatc tcactgcagg cctgaaatct 5460
tgggctcaag tagtcttctt tcctcagctt cccaggtagc taggagtata agcatgtgcc 5520
accatgctca gctaattttt ttttttcttt ttttactttt tgtagagatg gagtcttgct 5580
atgttgccca ggttagtttc aaactcctga cctcaagcaa tcttcctgcc ttagcctcca 5640
tattttcttt attaatctgt tgatagacat ataaggtgat tctgtatctt aactattgtg 5700
aacagtgctg caataaacat gggagttgag acatgtgttt gatatactga tgttctttct 5760
tttggatata tacccagcaa tgagattgct ggatcatatg aaagttctat ttttagtttt 5820
ttaagggacc tccatattgt ttttcataat ggctgtacta ctttatgttc ccatcaacag 5880
tgtaccacca ttcccctttt tctacatcct caccggcatt tgttattttt tctctgtttg 5940
ataatatagc cattctgtct gtggtgagat aatatctcat tgtggttttg atttgccttt 6000
ccctaaagat tagtgatact taggattctt ttttttcatg tatctgttag ccatttgtct 6060
gtcttttgag aaatgtctat ttggatcttt tgtccattta aaaataagat tttttttttt 6120
ccactaattg agatttttga gttccttatg tattctggtt gttaatcttt tgttgagtgg 6180
ttattttgca aatattttct cccgttcttt atgttgtctt ttcactttgt tgattatttt 6240
ctttgttgtg cagaagcttt tagcttgata cagtcccatt tgtctatttt tttttgttgt 6300
tgcctgtgct tttgaggtcc taccccaaaa gtcattgcac agaccaatgt cctgtagtat 6360
ttccccaatg ttttcttcta gtagttgcac agtttcaggt ctgagatgta agtctttaat 6420
ccattttgag ttgatttgtg tatatggtga aagctgtgca tctagtttcc ttctctggca 6480
tagccaatat ccagttttcc cagcactatt tattaaagaa actgtccttt ctccattgta 6540
ggtctttggc acctttggaa ataggttgcc tataaatgca tggattttta tctaggttct 6600
ctattctgtt ctattgatct atgtgaggaa tagtcttttg atttggtaat ttaatgcaat 6660
agaattatta atttcagtac catatgtgta taagtctata aagggcattg catatgacat 6720
gatttgattc ttactgaaat ctcactgccc tctcagaaat cttaccggat ggtttactct 6780
catagctcag tgagagtaag ctactaactg aggatcaaag agcttgtgac aaacctgaga 6840
cccaagtctt ctcacacctt caaaatctct ttccatcata caatctacta gctgctgaat 6900
tcacaagctt tttgtgcaag ctcataaaaa gcaaaatggt ttggtttttg ctttggccat 6960
gctaggtaca atgacatcaa tttaaattag cattggtctt accaagggga tgtagaaagg 7020
ggtctcctac tgacatttta atactcactt gaaagtagtg tttttccttc agatttcttt 7080
atataattag tataattact gtaagtatcc tttaatgttt tatatgttga gttagctgga 7140
agtgccaaat taaaaactct taatgatgaa tttaaggtat taaggtaaat tactccttca 7200
tttaatttaa ttgtaattgt taattactat ttaaaataaa gattaaggtt tgtttctaga 7260
tgccatttaa catgatattc cgggctgtca gttttatttt cgaagtttat ttcatatttt 7320
attaatgctt ctacataaat gacagtcttt agaaaattgg tagttaagct gctttatatt 7380
tttcttttcc tgcccatcgt ttcactgtgc tcctaaattt tacatctctt tattctcacg 7440
gtttcaacct tgaagaaggg gagcaaaata aatgaaagtg gctaaaaatt tttctttaac 7500
ccctagactc tttcctgttg tgccttaatt acatgcttga gtttttagaa taattataat 7560
aaagtaaaac taccaattta attgtattgt aaccgtgcag gatgggaaat ttctctcttt 7620
gaaagataag cttttaattg aatagattaa tggatcaatt gttacctctg ctttgctgcc 7680
agagattctg tttcatcaca gaagttccat gtagtactgg agagctcagt tgcctgaatc 7740
tttttgcaaa gcacttactt atgctgttgc ttcaccaacc agaacaaaac aggttttttc 7800
cttgagtcag ctttgtaggt atagggatga gtttggcatc ctatgtgatt tttttcacca 7860
ccagaagctg ttcagaatgt tattttctta aatacttcgg aaaaaagtct tgatgtattt 7920
tatgaaagca caaaaatagt tggtttctat gacagctgga ttgtcaatgt ctgttcagct 7980
tacgtggagg aggatgtcct acttaagtag tataggtaga aatagctgtc agaaattgct 8040
gcctttgaaa gcaatttgaa attatgtaaa aggaagtaat gacgaaataa agcaatttct 8100
gtttaatctg gaaaagatcc aaaagtaata ttgtaaagag atcttgagta atcattttta 8160
tcttcctaaa ataacccttg tttactcctg caaacaggta agaaacttgt gccattattc 8220
cttattggat gcatatagat ttctcacctt gtcattcaac tccttgcaat gttcaacttt 8280
acttatgcat ccagccttat cccaaaatag cctctttcct gtagcggctt ccttattatg 8340
tagcagccta ctctcctcac cactcaacag ttcttataca atctgactca agctctccct 8400
cttcatatta tattctctga gtaatttcaa ctcacactga atcttacttt cagtatttct 8460
attgtattgg tatttattac acatcacact taggtacttt tccataagtc tctagagggt 8520
ggtgtgtgag tgtgtgtgtg tgtgtgtgtg tataaatgca ctttcttttt ttttttttga 8580
ccatgtcaag tatagttcta tagtataata gaattggaga tcctttacat ttagagagga 8640
gtctacaata ggaggagtag gttaatttta atctgtggtt tgaaatcagg actttcaatt 8700
tttttttcag aggtaaagag caacttaggc aagttggcat cttgtaaaca gactgagtga 8760
agatatactt aaaatgcatc cataatttca tattttattt cgaaatgtga aagagcctac 8820
taggggtgtc tgtatctcta gaccttatca attcattcta gagaaatcta gagggagcca 8880
ttgaggagtt ctacctcctg tctatgttat agagcccttt cttttttttc tcctatcaga 8940
tgtagagtca attgctaaaa atgccacgtt tcttgcctct attattctag cttcattaat 9000
tggggagcag ccattctgat aacttacatt ttgctactaa aattttcaac ttgccctaat 9060
ccttcatttt aagccacttc attttttcct ataattaaaa atttaaatat gtggaggaaa 9120
ttctgtcagg tagctattac ttaaaaccta ctaagggcca ggtgcggagg ctcacgcctg 9180
taatcccagc actttgagag gccacgtcag aaggcttgag ccaaggagct tgagaccagc 9240
ctgagcaata tagagagaga cctgtcttca caaaaatgtt ttaaaaatta gctgggtgtg 9300
gtggcacata cctgtagtcc cagctacttg ggaggctgaa gtgggtggat cacctgatgc 9360
cgtgagttct aggctgcagt gatcggtgat tgtgccgttg cactccagcc tgggtgacag 9420
agtgagaccc tatctcaaaa acaaatcaaa accaaaaaaa aaaaaaaaaa aacaaaaaaa 9480
gaaacgtact aaggatccag tatagccgtt cttgcactta ataatcttgg tacaacctct 9540
aaaactattt tttgtagttt attttatttt gccttagaca ataggcgtgt ctatgttctt 9600
caaaatttag aaattatata tatttatgtg tgtgtgtgtg tgtgtatata tatatatata 9660
tttttttttt tttttggaaa tggagtcttg ctctgtcctc cagggtagag tgcagtggcg 9720
caatctcggc tcactgcaac ctctgcctcc tgggttcaag tgattctcct gcctcagcct 9780
cccgagtagc tgaggttaca gatgcctgta accttaccac catgcctggc taatttttgt 9840
gtttttagta gagacgggat ttcaccctct gccatgctgg tctctaacta ctgacctcgt 9900
gatccacccg cctccgcctc tcaaagtgct gggattacgg gcgtgagcca ctatgcccag 9960
ccgaaatgtt atattttttg tatgtctttc tggtctgatt tttggagaaa ggtgtatcct 10020
aaggatatgg cttgcttttg tttcttggta agcattttag ggtatcattt tgttttataa 10080
caattattta caagtgagat aagcatatat tccactaaga ctgaagagat tcatgtttga 10140
ctcagtatgt tctattaaca ttctttaaaa cacgtgaata tatgtctttc ttgttttcag 10200
gtgggttggt cacttctgtg caaattaata gaaatctgcc cgggtacaat gcaaagctta 10260
atgggacccc aggatgttgg aaatgattgg gaagtccttg gtgttcacca gtaagtatga 10320
tagatatgta aaaacaaact gccttgagta tttatctata cacataaaaa ccttcccttg 10380
atacactgaa tttgcaatcc aaggctactc ttgtgaaatt ctttgaaata cagatatttt 10440
tccttgagtc aattatttac atttatagag agctttaaac tcagaagttt gatttagaaa 10500
gcaaacattt aaggtaacat gtcaggagtt attttaataa tataatcata taattataaa 10560
actggttaac ttgtagattt ttgatgagta cttttgcatt caaaccatga agatattttg 10620
ccctttaata atagaactga tacaaaccac tagttcctaa aaaaatggga actgagaaaa 10680
gttagttctg tacgtagtaa tttgaaagtt gatgttctgt ctttaaatgg tacatttata 10740
tatattcata tatatacaca gtaagtttaa actacggctt tcaaaaagag taagaaagag 10800
gaaattacct ttcagcacat ctgcagccaa atcttgatga caattttacc agctatgttt 10860
ttgcagtttg cagcataatg acttcttaaa tgagactact tccttagcca caattaatta 10920
agaaaacctt ttctgaagaa gaatgtgttt tcaggaaaat acattatttc ttgacagtta 10980
aaaaatatct tctcagctac tcgggaggct gaggcaggag aatcacttga acctgggaag 11040
cggaggttgc agtgagccga gattgcagca ctgctgtcca gcctgggtga cagagtgaga 11100
ctctattaaa aaacaaacaa acaaacaaac aaacaaacct tctgtcatta actttaaatc 11160
ttttttatac gtaatgtgac ttttctttac cacagaaaag gaaattgtga atatatctgg 11220
cttacaatgg tatgcagttt atgaaaattt aatttatgaa aaatttttag gtgtttatat 11280
tggtgatcag tatcaagtag tgctacaaat ttagacaaat tagagctata tgtttggcca 11340
taagtgaaca tatctgtgct tatacatttt cccctctttg acaaatgtgt tgctcttctt 11400
gttttcagta cataaagggt gtgtttggaa agagcatatt tacaattaat tggagttctc 11460
atcttcaatc taatctttgt aattctatgt ttcagttcta aagtatacag cttttgatga 11520
ggaattactc agaatatacc agtaattagc aattgtaact tttaagtgtc ccttggtttg 11580
gttgagaatt tccaagatgt ccaaagatga gccagtctat aacctcaggg agtgtttggg 11640
aaactcatct agtcatattc ctgttcaaac cagctgttca aattaaatta cataaatatt 11700
tatataggaa atttgttcac tcactcactt actcattcac tcactttgtt catccagtca 11760
ttcatcttcc attcatcaaa tgttttttaa gcccctcctc taggccagaa acaatgcagt 11820
tgtaaagaag atagacacac tgctctctcc agtggagtgt attaggtcac tcccggcaaa 11880
aattgattgc aaaacagatt tctgtttttt caaggccttt tctctccaaa gacttaccag 11940
ttctgaagaa aaatttcttc cgtggtggta aagtcaggaa gagtgggaat ggtacaggga 12000
gaggtagggg cagggtgatt aggaggaaga ctggcagaga attgaagact ggcttcattc 12060
agttcctcca actgccaaat ggagattatg caacgtatct tgaatacgta caaagctcta 12120
gatgtggtca gctcagtctt ttcccaacaa ttcgccaaac aatgctgtgc aggaatagac 12180
tagagattat attttgggat taataatata gggattaaaa tctcatgaat ttgaactaaa 12240
cattattgat atgttaagtt cacttttttt tttttttttt tgagacagag tcttgctcta 12300
ttgccaggct ggagtgcagt ggcctgatct cggcttactg taacctctgc ctcccaggtt 12360
caagtgattc tcctgcctca gtctcccgag tagctgggac tacaggagtg caccaccata 12420
cccagctaat ttttgtattt ttagtagaga cagggcttca tcatgttggc caggatggtc 12480
tcgatctatt gacctcatga tccccccacc ttggcctccc aaagtgctga aattacaggt 12540
gtgagccagt gctaccggcc cactttttaa tatattatta atttctcttt taaaaacagt 12600
agcaatcaat aatttaaata ttgaaatgaa ttcttaattt atatacacaa actaacatct 12660
ttatatctct ctatatttta atatatcaac atgtctaaga taaattataa atttatatca 12720
catgtaaaaa tgggtttgct ctcgatgtat ataagacttc atgatatttt gaacatggag 12780
ttgggtgaaa atagtgaatc tgaatttttg aatttgaata tttattggaa aataagtagc 12840
gcttttacct ttttaaatga gacacataat agttccctgt tgattttttg tttgtttttt 12900
taactttatt agagttgaca attagaaatt gtttatattt aaggtatata gttgatttga 12960
tatatgtgta tattgtgaaa tattaccaca atcaagctaa ttagcattcc ctgttagttt 13020
ttataagcct gattcaggtt tgtagaaaga aacaaacaca catggccagg cacggtggct 13080
catacctata atcccagact ttgggaggcc gagacaggag gatcacttga gcccagaggt 13140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nttcactata gggaattaaa tacaatgaga 13260
gtaataaaaa ataggtgagc aaaaaaatct aaataagcaa atttctgagt atgatatttc 13320
attcttatct tgatttctgt ttttaactcc agattgattc ttaaaatgct aacagttcat 13380
aatgccagtg taaacttgtc aatgattgga ctgaagacct tagatctcct cctaacttca 13440
ggtaatacat gtatatgttt ttcgtgttga ttcagtttaa aaaaaattga tgccattaac 13500
ttaaattttt tttttttttt taaagatcag gattagggta gcttgattta aatgtcgtaa 13560
aattgcatct ttttttagac cttgtgatgt gacagccaca atgtaatcca aatatcagtt 13620
atttccaaaa ttctttctgt ttccatcttt tctccttatc tcttttctct atacgttgcc 13680
tctcaaaaaa tctcattcaa taccttggtt ttaaacatta ccttatatat tgtccccaaa 13740
tctctgtttg tagcctgatg tttgctccca aaatctggac ccacatctca tattctccct 13800
aggttagtgg tcattcatgc ccttgcatta ttacttcttt ctccatatat atcttgaata 13860
tattttctat aatgtatgtt ctggagtatg ccataatagt tacattttga aaatacataa 13920
cattacttct tgagtatttg ctagatgcca ggcttcacaa gtaaaatgct tcacattctt 13980
ttaaacacct aaacctgaaa acacccctcg tgatagggat tttatctcag ttttctaagt 14040
gagaaacact gaaatgcaga gaagttgctt cggccactaa gtggtagaaa cagggtctga 14100
ttctccatgt caggttcctt ccctgagaaa actttggcct ggaaaataac ggacctgaaa 14160
acaaaaaatc ttgaaatgat gcaacagttg tgggcattgc tgtgctggac actggctatt 14220
atataagttt cttagaagaa aggctgctca cagggagcta atcttgtagg gctgggagga 14280
gtttccttcc ctgtagggga gggcttttta ggttgagaga agtatgggtg cacaggcctg 14340
ggagaatagc ataagagagg ctggacatgt gattgggaag gtttgaaatg tcctcatcag 14400
tccccatcag tcctgctaag agatgaagac cttgctggag aaagaggaag atgagagtat 14460
gagggaaaaa caagaaagta ctcagcattt caccaccgct ttttatgacc atattgtatg 14520
gaatgcacta acagtcttaa ccatgattta atttaacctc atacttggga ggtatttttt 14580
ttttttttga ggggtattca ttcttcattt ggcaatggac aggaagatga gggtttatta 14640
atctgaaaaa tctctccaca ctggaatata ttaaagttag cctcatacag tactaccatt 14700
cctattccag tattattatt tttattgaca gaatagatgc tgtttgtgtt atgttttgga 14760
ttatgatagg agatgtttga tatagtaaaa gacaagagta tgacaagcag ttagtccaag 14820
tacaaagagg taacaaaata tttagtgagg aacagtgttt agcatatttg gagtgaagac 14880
aatgtgcaga gggataaggg gctgatgaga tacatgtact atagtcagtt gtgtgatggg 14940
tcttgttttt tcatactaag gagtatgaga agatcttaga agattccagc aagggatttg 15000
caagaccaca attgtgtttt agaaatataa tgcaggcaat aaactagttg ggtagaaatt 15060
ggggcctgta gagcaattaa gcatctgttt ttgcattcta gatgagaatg caaaacacaa 15120
taggaatgaa ggtgccttgt tcaaaaggca ttttgttcag aaggaatctt caagatgtgt 15180
aggagatata cttaaaggac ttggtaacga attgatgtgt tgtttggata gagaatgaga 15240
agagaaagga tggtggaaaa agaagatgac tcaggagttt ctcttgggta gctattggat 15300
tatggtatca ttgatgaaga cagggaacag gagtagacca ggtttggggt acctgtagaa 15360
tattcagatg atgtctaaga ggcataagaa tgtatttcag gtgtttgggg caagttatct 15420
agggtagaag tactgattgg gactcatgaa attgtaataa agtgaactga gaatttatct 15480
catttataaa gatctagagc ttgataagtc taacatctag ggcagttaag tggtttgtca 15540
ataaacaaac aaaaaaatcg tgagtctaca aaccattcac agtcttcatg taaaaattaa 15600
cacattaaat gttaaagcag atctttactc agagcatatt attctcttca aaataggtaa 15660
aatcacctta ctgatattgg atgaagaaag tgatattttc atgttaattt ttgatgccat 15720
gcactcattt ccagccaatg atgaaatcca gaaacttgga tgcaaagctt tacatgtgct 15780
gtttgaaaga ggtattttaa aatgtcaaat tccttaaagt atatataaga aaaaaaggct 15840
tatactggga aaagtagaac acaattataa gaagaagaag gtttctaaaa tcctactatt 15900
aagaaggggg agttgtctgt caagggtgag gaatggggtt aattcagcag tattgcttgt 15960
tttggtggag tgaattgcat tcatgggtta taaatcatgc cagtggagta gactttcttc 16020
agttgcataa caaggcataa ggtttacttt gaaaactgga tgtgtgggtg ttatgaaaga 16080
aaaaatacaa ctgaagccaa gcataggtta catcgggatt atgatgttga gtcatcatca 16140
gaagtcttag aaattgataa aggctctgca taaagagcca ggaggtttac aaagtgtccc 16200
tcaggaaaaa gactaatatg catttcatag cctggccctg agattggtaa ctgagattgt 16260
catgtaattt tagagttggt tggagtcctt gtttagtctt tccattgacc tgaggaggaa 16320
atgggtcaca gcagtgaagt gagcatcctg cctcagggca cagagcttgt gacagtacag 16380
ttcaattagc aattattttg agagcccctt ttgtatcatt atgggagcca accgtgctag 16440
gggtttagat aagaatgatt tttgcgggcc ctgtgtcagt tatcagttta ccagtctaat 16500
ttctcgcagt tcccagaatg ggatagatca cctaataact gagacagttt catgatgttc 16560
ttcacttgtt agaaaaactt aactgatttc gcattatatt atagggacac tggcataaaa 16620
ttaaaaaaaa attaatgttg atcacttaga gtgccgtatt ttctaacata tttctggcac 16680
cattctcaaa ctagataaac tagaatttta tacatgtttt tgaggttgtt gcccaataac 16740
agtgactcca aatggaactt actggcttga tcaaatgact ttaattgtga aaattaatga 16800
tctatatttt tgctgtctga tggaaaatca ctaagacaga gtatttcaaa gtctgattac 16860
ttgccatttg ctcaagttga caactcttga actgaaacat ttagccgagc tacccttcag 16920
cagcctacca ttaatgcctc cctttcaaat attgtaatat gtccaattct agttgaccat 16980
ctttattagt cactgtcagt tttctctaga atttcccaaa tgaaattgta aataattttg 17040
tttttctgag aatgactagc acttttacat ttcaaaacat tgagtaccga acatagactg 17100
aaacaaaatt attttaatct ctgtagcttg ctttcccatt ataacattct taggaagggc 17160
tgttttcaca gaaatatatt ttttatttaa ggagattaca tttttttaca caactatcat 17220
gaatgttgta atttttgaat aattaaactt ctgtatcatc tttaggctta ttcagtattt 17280
tgtctttcat tttttagtct cagaggagca actaactgaa tttgttgaga acaaagatta 17340
tatgatattg ttaagtgcgt taacaaattt taaagatgaa gaggaaattg tgcttcatgt 17400
actgcattgt ttacattccc tagcaattcc ttgtaagtag catttatatg tgatttcttt 17460
ttcgtatctg aaaaatcaca atatatctct ttctgagtat attttaacaa tatttttatt 17520
atttagaaac ttgtggatgc taaacccatt cattcattta tccatttaat taatttacat 17580
taattgacac tatactgaag ttggctgtgg gcttggtgct ggagaaacaa tagtggaaaa 17640
tacaaatgtg ttccttacct tttcagagct tgtagtacaa tgggggacac agataagtat 17700
agaggtgatt acaatggcag aagtgatggc agaagtaccc agagttagga gaacaaatag 17760
gaagtgaggc aatgtctctt agccaagatt gaataagtag agcttcctgt gcacagaggt 17820
gtgagctgaa gtgagagtgc aggcaaagtg gcccaggcag tgggaatggt tagtgtaaag 17880
atgctgtagc aagagagagc agactgcctt caagaagaca aaagtagctc agtaaaggtg 17940
tggggttatg agtgtgcatg cgtgcatgcg tgtgtgccac tgtgcatgcg catccccaaa 18000
tatcctgtcc gtttgtgttt cattgacaga ggcaagggag accttgataa gaggcagtgg 18060
gtgaggccag agacatggag tggagagcat gaagggccta aaaagctgca tgaaggagtt 18120
tgaattttat tgtgattctt gattagcatt ttaatgatgc tttgaaattt agccaccttt 18180
ttcaccaaaa aatattaatc agaagaaatt aatttgatgt gtatgttacc aatgattact 18240
aataagctaa aataatggct catattctgt tttgttttgt aaatgcccat taacactttg 18300
tatttcatgt attacttgtg tgggtttcta caggatatac atatgcattt atctagtgat 18360
attttcatcc tcacacatgt gaagttttga ggattcaacg agttaaaaat gtagagtagt 18420
acctggcatg taataagtgt tctaaaatca ctgacaggat tattacacaa tatgtatttt 18480
atatgtatgt tgtatactat atgtaattgc atttatggtt tcagatatgg aaatcactgt 18540
gtcagtctgc aggtgtgagc cttcagtgta ggcagagtaa aaacccaatg cccttgtgaa 18600
agaatgcctt ttttttggtg atgtttataa aatcacaacg ttttcttatc cacaggaaat 18660
taaacactag aaagtgggtg ggactgaaca ataatagaga aaggccatgc ttttacattt 18720
ctctgagtca tcattgccaa caaactgaat atatttttca ttatactttt ccttggctat 18780
atttattcat ttatttattt attttgggct ggcagttttt ggaatccatt gttttccacc 18840
cacatctgac ataactccag taaaaatgtg ttgattcata atacaaaagt caaagaaagt 18900
ggcagctaaa aattaagact caagagtttt taaagcactg attctaactg aaaaacattt 18960
gcttttcagt ctttaagtct attgttttga atcaaagcag gtaactcctt taacagacca 19020
tttccataca ttattaactt tttttctatg tttaagcatt ataagacact ttttgtgaaa 19080
acagttgatt agttttggct gtgccaaaac agatactaaa atgttttgca aacagccctt 19140
tttaaaaaaa aaaaaataaa agaacagtta acatttgatg cagaaataga catattttct 19200
ccatgtaggt tcgcacttca ctccctttat tgattcattg ctttttctgg tagagtcttt 19260
ccttcctttc tgtttcacct gtgtttgtcc cttagactta tattttaata ttgtgcctcc 19320
cctttttcct tctcccatct tttcttccac ctattttgga gccttcagga agctttattt 19380
tgctgccttg tacactggtt gctctcctgg aatggaggag gaaacaggtc ataactgatt 19440
ttaactcttc tatctggtga catattcttg attttctttc ttttggttgg gggaaaaaaa 19500
atgcaaaagt tattatccag tgaggttgag cctcgttaag aaagagaccc tccaatttat 19560
tttttgaaaa cttagaccaa tacattacat ttctagactt tcattttcag tacttttcat 19620
ttcgttttca gtactaaaag tactctgaat ttttcctttt ttttgatctt aaggctttaa 19680
gccaagaaac aggaaagaag taaatttttc ttaatgctaa agatgagtcc tacattccat 19740
tatgttatca atgaacagcc tagaattttt tacagctgct taacggaaca tgatgtttaa 19800
atttggaaat gcagtcatta tgctgccatc tatttacaat ctatataaga catctttgta 19860
tgcatatttc aaaggggaaa atggttacct tattgataat tatgatctct ttaaattcag 19920
gcaataatgt ggaagtcctc atgagtggca atgtcaggtg ttataatatt gtggtggaag 19980
ctatgaaagc attccctatc agtgaaaaaa ttcaagaagt gagttgctgt ttgctccata 20040
ggcttacatt aggtgagttt cttagttaat atatcatcac aatctgtatg atatacatat 20100
atataatata tatgttgcat aatgatggat aagtagcata ttgacatact ttgaatgaaa 20160
atattgtaaa gtcccagaaa aaaataaatt aaaaaaaaga aaatactgta aactaccaaa 20220
ccgttttgct atgtttagat ggacttttaa aaggagtgtc aaaaataggt gtgtagaatg 20280
tgaaagaagt attatcttaa tcttattttt atagagatag ttctatagat gagttttttt 20340
attgttgagg ctatatttaa aatgtaatta tgtaagaatt gatatataca aaaaatatgc 20400
ataacatata caatgtaaag cataatgcaa agaactcacc atccaactta aatatcgtat 20460
attcccagtg ggggaagcta ccctgggctg cttcttgccc ttgctttctc tatagaggtt 20520
aacactatcc agaattttgt gtttacaaat cttttgcttt ataaatatga tttactacat 20580
tttcatgttt ctttaagtaa attgttaaca cttgcctcct tttgcttcat cacaatgtaa 20640
ttatattgta tgttgtcttc tgcaattttc aaatatcaat atgattataa gaatcagaaa 20700
tatttttgca tgtggttgct agtagtagtc tattatttgg aaataccaca atttattttt 20760
ccatttttct atcaatggac atttgggttc tttcttgttt tatgctacta ctatctgtgt 20820
tgttaggaaa atataaataa gggttaatat ttttaaaaat atttacttgc cattggtagg 20880
tccttctttg tgaaatacac aatctgtcat ttatcaatat ttttcatagg atagtctgtc 20940
tttttaaaac tgattcatag attctggaca ataatatttt gatggtaggt tatatgtatt 21000
gaaaatacct tcccttgact tgtagcacgt cttttcacca tctttatagt ggcttttgtg 21060
atatagttaa atttaataat cagttccttt gtgatttact ctatgtatct tgtttaagaa 21120
atctttcctt tccgagataa taaatatatt gtatatttta ttccaaatct ttctcattta 21180
ttaaactgtt gcagtttgtt tttgtaaaga acccgattct ccctcttttt ttcagtgtgg 21240
agagctagtt accatcatag cacaatttat tagaggttca cctgtttccc agttgtgtgg 21300
tacaccgact atatatattt atgtttctgt ccctgctgtt ctgttgcatt aatctgattt 21360
gtctgaatca atttaacgct atttaaatta atagttctgc aagtcctgat atctgaaaag 21420
ctagtaggtc aagtcactat acattctttt ttaggcacag cttgcctttt ttcttgggcc 21480
tttactattc catacttatt ttagaattaa cttgtccagt tccttggaaa acactgttga 21540
gattttgact ggaattgcac aaaatatgtg atcattttaa gaagaactgg tgtctttaca 21600
ttataatttc ttctatacgt gtcttgcaca tctttgttag ttattgctac atatcttatt 21660
tttattatta ttgtaaatgg tatttctttt tacatcgtat ttttgaactg tgttttcata 21720
aagaaatgca aatgattttt ttgtatattg agctaaccta cctttctaaa ctctattaat 21780
tctgacaatt tgtttccaaa tgctcttaaa ttctctacat agcaattata taatttgtaa 21840
ataatgacag tctgagttct tcctttctgc ttcttatatt ctttatttca tttccttgtc 21900
tttttacatg acccagaatt attaatacag tgttaaatag aatcagtgat agtagacatc 21960
cttgtcttgc tctttttcct gattttaaac agaatatttt taatattctc ccatccaaaa 22020
taatgcatct tacaaggttc tacattttaa aaaaaatttt aagaaatttt attttatttc 22080
ttctttgctt ttatttttac aatgtgggct ttaaaaaatc acgggtgaat atttaatttt 22140
atcaaatata cttaaaatgt aagtcttttt tttcttttca ttttgttaat atgaagaaat 22200
acatctacag gttttctaat actaagctac tttgcacttc ctgataaatt taacttggtc 22260
atttattaga tttttaaaaa cacttataaa aaaatcttgt ctgtttattt tcgcatatac 22320
caggtgagtt ttggcagcct cttgtttttt tcttttttac gctttctttt ttttaaaaaa 22380
atccttctat ttctttaatg attaatacat ggctattttg tgttttgtat ctgataacta 22440
tatgtaaagt tctggggagt ctaaaccaac tgcttctagg ctgactgccc atcagtagcc 22500
ttgttttctt gtatgcttgt gagtttctct ttgattgagt ttaatatttg aacatcctga 22560
ggacttaaat taaagatgct ctttcagagg tgtttgccag aagtcagagc acaggactga 22620
cgtgggagca gtttaggatc ttaagatcta ggcttaatat gggagactct ggttgaatta 22680
ccttaccttg cagagagtct gaaactcgat tgttgaatgc agcgccgaaa ttcatgcttt 22740
ccctcgagac tactctggcg ttcaactcac agctcttgtt tcagcttctt tttgaactcc 22800
ctgtgcccct caacacacac cttggaaact tccttgatat ttttgtgagg acaacaatgc 22860
gtgtaaaagg gagtggctgg tgactaataa ggaatgatgg ctaactgttg gaaattgatt 22920
ctgatgacac tttcccaaaa ggataaccag gaatattttg tgcaaaatta ggattattat 22980
aataggcatt tagtttttca tcattacaaa tttttgggaa aatcattaat catttgaaaa 23040
aactaattga cacatctccg ttgtagcaac tcgtattttc acttctagta tcatgattat 23100
atcccctgta taatttggaa attgatttta gcattaggaa agttcctagt ttcagttaaa 23160
atgaattttt tgtaagttga attctatttt aaatgcacaa ctttagtttg ttatttcttt 23220
ccttgataag catttattga atgttgttat atgactaaga ctgtaagatg atcatgttta 23280
atattttcac atttctttca tagtttccaa agtgtatata tacacttata tatttgatat 23340
gtatgaatct acttatgtac tgtatatata aatataataa cattgtatat aaatgtatat 23400
aaatatatat acatgtatag aaatatacaa atgtatatac atatatttat atacaaatat 23460
acaaatgtct ataaatataa atacatttat atatacaaat ataaatactg tgcatatata 23520
tatgcacaca gtatatattt gtatatataa atgtgtatac acacacacac acacacacac 23580
acacagtatt ttttgatcca tgcaacaatc ttgggagatg ggatattgtt attatttgta 23640
catttacaga tgaggtcctg tggttcacca atctttgtgt tttattcaag attatgtaag 23700
cagtaagggg tgaaatcagg ctgagaaccc agatttcttc atccctaaac aaagtatttc 23760
ttctaaaatt tggtagccat ttactagttt atctctatca ggttaccctt tattcattat 23820
ttttcgtgag aaggttgtag ttgtacaaac tggctgatat ctgataatgt tttaatctaa 23880
ttcaaagttg atttcttaaa tccaggtgtt agagtagcac actactgtac aactctctgt 23940
ttcatgtttt acacagtcaa gttacaactt gcacatgtta cattaaaatg tgagttcgcc 24000
ttcatttctt gaaatgagcc agaggaagaa gtgattttgt ttttgtgatg agggaaatgc 24060
tacttgactg ccaaattggt ctagaagagc acattaaagg tgcttgattt tatactgtta 24120
aaattaaata aaccatggca actgtcatgt cgtatgcaac ttttgtatta ttctgtaaga 24180
ttttttaaaa ataaaaagag atcaaactga tcttcaggta aagatgcttt tttctcttgt 24240
ttatctctta gtgaatgatt attagttcca tttaatgggt agataattta ttgttgctgt 24300
tattgtttca aaagtagctg aataaaatgc ttaacttttt cttcatagtt aaaattaaaa 24360
cctcaagtaa gtaaatattt aacgttttgc caaattatgt aatctaatta tgggcttaat 24420
gcatttaagg actctgtaca gtttgctatg tattttcaca caagttgtct gaacataggt 24480
ctagtcttcc tgctgttttc tgagtcacac agtgagtcag tgacggaaca gctgtaggca 24540
gtggtgtggg tataataggg aaaagagagt gatggggacc acccaagttt agacaagctg 24600
gtaaaagtag aagaaaatct ttttgaaaac actagtgatc tttaagggct gtggagaatg 24660
tttgcttggt gggtgaatgt gaaagaggca acagcatggg aaggtgttgg taaaggagct 24720
ccatagttgc ttaaactgcc ttttgattgt gaggccgttg atgaatattt gggctttagg 24780
ttttttatga tacaggatct tttccatttc tggctttgta tctcagagat cacttagtta 24840
cacttataga tgaacaggag ttttaattct ttgttttaga aagaagcttg gcaattgtta 24900
gtgagttaca aataagccaa atggaaaaag gtacatattt ctggaatatc acgtaaagtt 24960
tttcctcata aggatttaga ctcttgggtg tcatattaat tctcagaaga atgggtataa 25020
aaagatatgg aacttcttcc cagggtgggt tggaggtggt gaaatatctc atttatttta 25080
gtttttattt ttttttctga gatcatcata gacaagatca agtaatggta agcatgccaa 25140
tgaattttct gaacactatt cctttaagtg aaagaagagg gtttcagcaa aactatttaa 25200
tattggatct tctaaaagac agatttaaga gtttcatctt taaaagtcag aaaaattaag 25260
ttattttata caatgaatat tgccgtgcca tgtgtaacag acgtgacatg agagggaatc 25320
agagaacatg cagttaatac aacccaaact agtatcatta tttttgctca gtcacttcca 25380
ttgtctaagt aagataaata aatgacagca taaaataaaa tttcaaaact actcaatcat 25440
attaagctat tttaattaca gtaaatgttt taatgccatt aaatattcat caccatccaa 25500
aattactgat gtaaatagtg ttatatgtta aaggtaattt aacttccatg gatgagaatt 25560
cagctaatgt ttcacttaac ttttaggtaa tttttttaat atcctggtat taaacgaagt 25620
ccatgaattt gtggtggaag ctgtgcagcg gtacccagag aacgcagcat tacagatctc 25680
agcgctcagc tgtttggccc tcctcagtaa gtaacttcac taaaaaggag attcttccag 25740
aggcatttga catcaaatat gaacattgta acaagagaat catatgtaca gatgggagtt 25800
ctgtcctgtg tagctcattt tctagtagag aatactttca aggaaactaa cagttatgac 25860
aagtatacac atctccatgt agagttttgc tttacatcat tcttgattta gctttgtcat 25920
taagcagcta atctttttta aaagaatttt tacttgtggc caggcatggt ggctcacgct 25980
tgtaatctca gcactttggg aggccaaggc gggtagatca caaggtcagg agttcgagac 26040
cagcctggcc aacatggtga aacctcgtct ctactaaaaa tataaaaatt agccaggcgt 26100
ggtggcgggc gcctgtaatc ccagctactc gggaggctga ggcaggagaa ccgcttgaaa 26160
ccagagggta gaggttgcag tgagctgaga tcgtgccact gcactccagc ctgggcaaca 26220
agaatgaaac tcagtctcaa aaaaaaaaaa aaatttttat tttaaattct ggtgtacacg 26280
tgcaggatgt gcagattttt tacataggta aacgtgtgcc ttggtggttt gctataccta 26340
ttaacccatc acctaggtat taagcccagc atggtttagc tatttttcct aatgctctcc 26400
ctcccccagt cccatccccc aatgggcccc agtatgtatt gttcctctcc ctgtgttcat 26460
gtgttctcat tgttcagctc ccacttataa gtgagaacat gcggtgtttg gttttctctt 26520
catgtgttag tttatttgag gataatggtt tccagctcca tctgtgtccc tgcaaaggac 26580
atgatatcat tgctttctat ggctgcatgg tatttcatgg tgtatatgta ccacattttc 26640
tttatctagt ctatgactga tgggcatttg ggttgattcc atgtctttgc tattgtgaat 26700
agtgctgtga tgaactaatc ttttcaaata atccttctct agtctattag gttttttttt 26760
ttttttggta ccctcttcct gattttatta tttatctgta taggatggta gtattatgag 26820
gtgtgtaata tatcaaaaat tatctttata attgaccaag gcttctacta aagcacacct 26880
cattctgttg gtaatatttc aaaatattga attagagttg gtcaaactgt taagtaaatc 26940
atatatataa tgcttttatt tattttttaa tttttttcaa gctgagacca ttttcttaaa 27000
tcaagattta gaggaaaaga atgagaatca agagaatgat gatgaggggg aagaagttaa 27060
attgttttgg ctggaagcct gttacaaagc gttaacgtgg catagaaaga acaagcacgt 27120
gcaggttgga ctctcataaa tattagagtt actcaaaatt gtgttttcta atcatttata 27180
ttttgacaga tttctttttt ctcccctaat ccaggaggct gcatgctggg cactaaataa 27240
tctccttatg taccaaaaca gtttacatga gaagattgga gatgaagatg gccagtcagt 27300
agttttgatt ttatatgata gaaaatttca gttatatttt aaatcaatac ctacaaaata 27360
ctttaaccat aacttttatt gttagaaata tttttgatac agccttttag ttttagatgt 27420
tgctgccaaa tagtagtatg tatgtagcat tttgatctta ttacctccag gagttagaaa 27480
aggtagcatg tttgagagtt attattgaga gatttggaat caagaatcat ttggtaattc 27540
acaaatcatg gagaaagaat ctgtttcctg gctgttcgtt ttaaaatgcc atattaattc 27600
atcttgggtg atagaaattg cagagccatc tgtgatcttt tcttctgtgg tgactagcca 27660
gcaggttgtc aatatcagga attagatttg gttagagagc tccctatgat gagttcccat 27720
ctgatgtgac agagttgacc tgtcttcttt tgagagggtt atttgaagct gtcatctcca 27780
gataactctt tcactaggag tgccattcaa acatcataag actggcactc tctcccaaag 27840
atacaaactg tagcaaggag ttttgtgcat atcaggtttg tttcatatcc gtgagccttt 27900
gtgttttatg gcaactgatt atgcttgtgc tatttgcaat ggatatcctc tgggttttaa 27960
attgtgaatg acttattttg gaaacaaata gtagtattct acatctgaaa tcttgacagt 28020
ctatttgttt aattatctat tgctgataag aggggaatta ataacacaga tgctacttaa 28080
ttaaacattt tcattttgac aagaaacagt agttcttttg aaaactatgc taaattggca 28140
tcttaataat ctcatgttga gcaaggcttt tggagattag ggtaagggag attcatgttg 28200
cagtttataa attttagttc ataggatacc tgtttctcaa tatccataag agaactttaa 28260
aataaatata ttattaaaac aaagaaaata aatttatgtt gtgcatcttt aaaacttatc 28320
ttgcttcttg acagtttttt tattgttctt ttctttttac cattatcttc ttttcctcac 28380
tttatgtttt tcctcagcat ctctttacat atctgctaag cttctttatt tctctctgct 28440
gcttattggt ttttgaaaaa gcataaaaat actaatttat tagtatttaa ttaatttgag 28500
tcttaaaaat gaactataat taactcttgt aaggggaggt ggcataaaat attgtttaca 28560
tgctcttaat tgttgttaga gatatttgat aatggtaagt gagaatttga ggtaattatt 28620
taaaagatta ctactaacat tttcgttgaa tttttgaaag tttcccagct catagggaag 28680
tgatgctgtc catgctgatg cattcatcat caaaggaagt tttccaggca tctgctaatg 28740
cattgtcaac tcttttagaa caaaatggta agcagtgtgc catattttca aataaaggga 28800
aacacatttt tgtggtagtt ttaattataa aagctatata ttgtgagaaa cttacataat 28860
ttataaagct atatattgtg aaagatctct ctgtgtgtag agatatattg gcatgtggat 28920
tatgaacata taggtacaag gatgaagaat aaaataaaca tttattgtat atttttctgg 28980
acttctatgt gtaaactcac acatgacata tacaaaattt tacatatttt gtagaaatat 29040
tatactcttt cataaccaaa ttttattttc ttttttatgt tgatacatgt gtattctcac 29100
attatcattt tttattttta atttttaaaa ttaatttttg tttttagata tggtctcact 29160
ctgtcaccta ggctggagtg cagtggcatg atcatggctc actacaacct caaacttttg 29220
gactcaggtg atcctcccac ctcagcctct tgagtagctg ggactacagg tgtgcactgc 29280
catgcctggc taattttttg cagagatggt gttttgccat gttgcccagg ctggtctcga 29340
attcctgggc tcaagcaatc gatctgcctt ggcctcccaa gtgctgggat tacaggcatg 29400
agccactgtg cccagcccaa attatcattt ttaaaagcta tgtagttttt cattgcatgc 29460
ctgtattcta ttttatgaac caatttctta ttaatgaagt ttcagtttgt gtctagtggg 29520
atgtttctga aacccataat acataccaat gatcactttc ctcctctgtt ttcctttata 29580
catggttcct attattttct tgggaaaatt tcatagaaat gcaactgggc agaaagctat 29640
tcaccatttt aaaatctggt aaaattgtct attataaatt ttcacactat actttttaaa 29700
aaaatggttc tttacatata attcttataa gtcttatagc tttgtataat taagaagaga 29760
aaatggcttg tataccttca gaaagacatg agttttaagc ttatggttca ggctgctcaa 29820
atttcttccc ccgtaaacag gaatactgac agaaatcctt aggtgaaaac tcatcataaa 29880
ggcattggga cttggcagct tttgtaggat atttttatag ggcgaaaaat agagaaaagc 29940
actgaaagcc agagacagag accagtgtaa gcaccagctt ttaatagaga acctgggtag 30000
ggtgggaaaa aaaaaataaa gccaccacct catgcatgtt tctttatatc attattgaag 30060
ctaaataaag aggaaaatca tttcttcttc ctcttcctcc ttttccatct cacctctctg 30120
atggcacttt aataaaacgc ttggagtggc aagggcactg acagacagac aggggctgct 30180
ctcaaggata atgagtccga gtaacagggg aaggagagga aatcactgtt ctcgaatctc 30240
tcatattcta ctgtgcagtt aaagaggtct ggacagggat ttcactccca aaaatgagga 30300
ctggactttg tggcttctgt tgaggcacct tagagtggag gtagactttt actatgtaca 30360
gacaacattg tgttggtgac gtcattcata accacctgga aatctccttt gatatgcaaa 30420
ttaaacaacc aaaactttgt gaaatttcga ctgcttccta ttatgatgtc tgaggactgg 30480
ttacattcag agtacaccct gatgtcttcg ttcagttctc tgctctttct agttccctac 30540
ttctttgttc ctgaccacct gtcaggtaaa atgtcctcag atccttttgt attgtctttg 30600
gagttctgcc ttaataaagc atgaagaact tgagtagctc attcatcacc tttcttgggc 30660
aatttctcat tgaaagacac ttgagaacct ttgggtgtac agagctgggc atggcttttt 30720
tagaaaaatg gctacactgg caggcagaag aactgggtcc ttggaaccat ggaggtccca 30780
aagttgcaca catcttgtgt gacattttcc attcaattaa ttaactaata ttcattgagc 30840
tcccaagtgt ctagtgtctg taggcacttg ggatacattc attaagtaaa aatcccaggc 30900
tcatggaatt taaactgtag tagggaagat aataagacta actaaaatat gtaatatttg 30960
aggcagttaa gaataaaaaa tgaagcaagg aaggagaata tgatacgtta gaaatcagag 31020
gagatgaagt tgtgaatagg cagccaggaa agaaggtgtc tattgagtaa gacctgcagg 31080
gcgttgcata ttgttttttg cctcttaaag cagttaattt cctgttaaaa tggagtggat 31140
gagatcagga gtattatgta gatagctggt agatgcgata gcatgtaaaa tgttctataa 31200
agtctgacgt gactttatga tgaaatttct tctcctaggt ttattgcttg caattttcaa 31260
gtcacacatt gggttactgt ctaggatagt gattcttaaa gtgtggttcc tggaccagca 31320
gcatttgctg gggaaacttg ataaacaatg taaattcaag ggccccatac agaccttctg 31380
aatcataaac cctggagttg agacccagca atccatgttt taacaagctc tctaggtgat 31440
tctgttgcac gctacagttt gagaaccact gatctagtgt tgtttttgtc ttttaaagcg 31500
tcgtcttggc tagaagctag ccactttggg aaaggttgtt acaacttctg atgtgatcga 31560
gcaaagtaac caactgtttg ttgtatatta acgtgtgcta ttctgaatgt gtttaaaaga 31620
tacgagtttt tcaggttctg gcagtattgt agaatgtgta tgtgatttct gtttgtttcc 31680
atgttttgtc ctatcttctt gagatagact acttatttta tttatttttt atttatttat 31740
tgttattttt tttattatta tactttaagt tctggggtac atgtgcataa tgtgcaggtt 31800
tgtcacatat gtatacttgt gccatcttgg cgtgctgcac ccatcaactc gtcagcaccc 31860
atcaactcgt catttacatc aggtataact cccgatgcaa tgcctccccc atccctcctc 31920
ccccctcccc atgataggcc ctggtgtatg atgttcccct tcccgagtcc aagtgatctc 31980
attgttcagt tcccacctat gagtgagaac atgcggtgtt tggttttctg ttctcgcgat 32040
agtttgctga gaatgatgat ttccagctgc atccatgtcc ctacaaagga cacaaactca 32100
tcctttttta tggctgcata gtattccatg gtgtatatgt gccacatttt cttaatccag 32160
tctgtcactg atggacattt gggttgattc caagtctttg ctattgtgaa tagtgccgca 32220
ataaacatac gtgtgtatgt gtctttatag cagcatgatt tataatcctt tgggtatata 32280
cccagtaatg ggatggctgg gtcatatact tattttaaaa gcagtactta agttaaaact 32340
ttttatgttt ctttttctgc cactttcaaa gtgttgaatc acagtgtgta atgttggaat 32400
tgatactttt atagaggctt caagacaatt gatgtttatg tggaaacttg aagacaacag 32460
atttatgttt agtgaaggaa gtttattgca aagaggaaaa ttggcctgtt gtgatggctc 32520
atgcctgtaa tcccagcact ttgggaggcc aaggcaggag gattgcctga gctcaggagt 32580
tcaagaccag gctgggcaac atagtgagat cccctctcta caaaatatta acaaaaatta 32640
gccaggcatg gtggcacact tgtagttcct gctacttgga agctgagata ggaggatcac 32700
ttgaggccag gaagttaagg ctgcagtaag ctatgatctt gctactgcac cccagccttg 32760
gcaacagcga gagatgctgt tacaaaaagc aacaacagca aaaaaagagg aaaattattc 32820
cttaatcatt attgctggaa tatagttnnn nnnnnnnnnn nnnnnnnata ccagttgtaa 32880
agcatatctc tatgtttcct agagtttggc attactttgt gaaaataacc ataattactt 32940
atattcttat attaaatgct tatattaaat gctttccatt cctttgtata tgatggacta 33000
tattctaaat cttatggtaa aattatgaaa atatgctttc atatccataa gtgacacttt 33060
aaaaaatctc agttaatttc agaaaaatcc tgttatcaaa aggaatatac ctgaatgttt 33120
tggagttaat gcagaagcat atacattctc ctgaagtggc tgaaagtggc tgtaaaatgc 33180
taaatcatct ttttgaagga aggtaatata gattcattaa cttgtacaga atatatcata 33240
ttgggccagg tagaatatca atatttcaag catatttcta acaatgaaaa gaaaaagaaa 33300
aacgtaagac acttgaaaat tgaagcattt tgcaatgtaa tctcgtgtca ctagtaccat 33360
agacttactt tatctgaaca ctgaaaggaa tggcaagatt gtggaaacat gttgaaggtc 33420
tggttttgaa cctgatgctt gatgttgact gtattttgaa aagtggtaat tgtatagcac 33480
atagcataca gcagtttttc taatattgtg tgtgtgaaag ttataaaaga taaaatcagg 33540
atatagcttc ctaattgttg ttctttcaca acgaatatat tattccttca tttgaatgaa 33600
ctttggcttc tcttcctgct ctcaatcttt agttagggaa aattttaact acatctagtc 33660
caagtgcaga gatgttaaga ttatacagct gctggttagt ggcacaacag agaccagatc 33720
ctttgatcta tgtatggatg gtggtgggat agagtgggat gaggtggggg tgaggggtgg 33780
taggtgtggg cagaacttgt ggcttaaaaa aaaaaaaacc tgtttaaaag acgaaaaatg 33840
aataatatgc agaaggtacc tactgtagaa taggctcagt gcctttttgc attttgttaa 33900
gccaaaaaat atgatgtaaa tttggcattg tctgagtaaa tttcaaacaa aaagaggcta 33960
tatagaaaac tctcatgtgt agacaaaata attggcacag aagttgcagt aaaaactaat 34020
tttgttcctg gctttgccac taatttgagc caactgtttc atctctaaaa cttcatgttc 34080
ctcattggta aagaagaatg ttaataacaa ctttgaaagt tgtaagctta gaatgtaagg 34140
attaaataaa ttaattttta caaagggatt aggataatgc ctgctacatt ttaagcactc 34200
aacaaattat atctattgtt atactgttat taagtgtgaa tagatgaagt gcatgtagca 34260
tgaaatgtaa cataactgca gacttgtaag aagtagggtt acactgtttt taacatcagt 34320
ctagctaatc tatgtttata tatctcttta agttgtattt ctcttattta aatgttgttt 34380
ttgaacactg agatgaaaag tttatcttaa atgttgattt taatggcgcc gaaagtgtgc 34440
aaacctttat aaatgaggca caaaaacagt ggaataaact ccagtctagg attctgtaga 34500
ttctgggcaa gcgatttgat gtttctggct gcatgctctt aagtaaaatg tgtacagttg 34560
cagtcctgga gattccacat tggctctggc aatgtgtctg cccctagaga actcatgtta 34620
gttgagagac tgatatgtaa acaggttatt ataatacagt ctcagaatgc agtaacagta 34680
gtgtgtaaaa tacacaatgg taagagtaga gtggacccag ctggggttac ctaaggaggg 34740
caggctccaa cagagggatg tgtttaaact gggactttaa gttggaaaag aaggagtgta 34800
tctcagtgtc cacagaacca tgcaaagtga gaacatggtt ctgatatgca caagtttcag 34860
ttagcaagta aagcaaggat tgactgtatt aaagttcata gtacctaccg cattctagtc 34920
aagtgacatt tgctcatatg taaaagaaag aatagcttaa ataccttaga gaaaacaaga 34980
ctgtaaaaca aattaaaagt aattaaggat actatataag aagtccagtg atgttaatct 35040
ggaagaggaa ggttcatgtg ctgtaaagag gccttatctt ggggtcagac aagtttgggt 35100
accagccttg tctctgtcac tttctagtga caaaacctga atatttaacc tctatctgcc 35160
taagttcttc atgtagaaaa tggggataat aacacctacc tcctgggatt gttgtcattg 35220
acccacccta ggtcagaagg atgttgttag ttttatgaaa tgaaataatt cccaggttac 35280
tatgaattct atcttatgag ttcaaagttt agacaattaa aattatgtat gcttatactg 35340
ctgatttcaa atgcattttc atatagtctt tcctgataaa atatattggt tctgtcctcc 35400
tgtacttact tcaatttggt gtttatacca ttgaatcaga tcggtcttcc aataaacatg 35460
ccaattttat atccccagca acacttccct ggatacaatg gcagcagtgc tccccaaaat 35520
aataacagtt atgaaaagtc atgagacatc attaccagtg cagctggagg cgcttcgagc 35580
tattttacat tttatagtgc caggtaagtt acatagttga ttgtgagaag agataacaat 35640
ttaaagggat ttttgacttt tcatgaaata gcaattttct aggcaaatat taaaagacta 35700
gtttctgttg actaaatgta aatctttctg ttacaccaaa aacaaaaata ggggttaaat 35760
atgatgcaga attggcattt agattaattt ttataaaaaa tatgaaattc agtaatttat 35820
ttattttaaa taactacaat gtaagatgtg gagattttat ttttaaggag agtgttcatc 35880
tctgataatt gttttctatt tttgttgctg tgacctgagt tcaagctttt tttcacttgt 35940
ttgaattgta ctattagcta attttcatac ctattctctt ccttcatttc catccttttc 36000
ttactctgtg attgaattaa tctttctcca atatggcgtg tactcattta cctcaatggc 36060
ttccaccctc cacccacctt taattcctac ttacatctgt tatcacctta tttgttctca 36120
aaagcccctt taaaataccc atgtctctat tcattcagca catttattag gtgcttctta 36180
tggtctaagc actgtgatgc tgttaagctt tgaaagatga attggaaaaa aagcacaact 36240
gtactattat aggagcttag aggtagatgg acgtgtaaat agttaattaa caggcagtgt 36300
gagaggggcc atgatagatg catgtataaa aggctttgag aatattgatt gaggcacaaa 36360
taatttcttc agaggagtag gacagagatt ataatatttg aggtggaagg gtaaatagag 36420
ctggcctggc agaaagacga aggaggacat ttcaagcaca agaacatgca catggtcagg 36480
ggtgagtgag gcatagagga tgaggagagt agtgcatggg gatgagtgtg gaaggacagg 36540
ctgaggccca aagaaaaggg gcttgaatgc agtgttgaaa aatctatgcc ttgtaacaat 36600
ggaagttaat ccaagtttat gaaaagtgtt tacagattgt agtgtcacac cgaattttgc 36660
aactaaagac aatagcattg tggtgtagag gatgatagac agggagagag actatataaa 36720
aggagattgg gttggaggtc tgtggtagtc aagtgagacc cggtgaagga accctgcagt 36780
ggaaacacag atgagagggc agattggaca gatggttggg agatctgttt gatgtgacat 36840
cgtgatccct aagtatgagg gatgatgctt tgttctgtga agttcccaat cttttgcagt 36900
catttttgct ttgttctttt aaaatgaaat cttcctaaat ctatcatttt ctctagttat 36960
atagacattt tatgtttctg cgtataagag tattattcga tatacaagtt ttttaaggac 37020
agagctttct tcagtcatgt ttttccagtc ctctggtagc tattcagtgt tttaaaaatt 37080
gagtcatggt gtcctattca tagtttcagc ttaattttga gacataattt aacagatgta 37140
attttgcttg caaatattat tgcgggtttt attgaatttt atttttagat tgtaattaaa 37200
aacaataaaa atgccttttg attatcctta aagttgacag ccttattctt ttgagagagg 37260
ttttgagttt taaagataac cagaggacac tcaaaaaccg tatctgttaa tgaaataata 37320
ttcttttagt ccaaaagtaa gtttggaata cagtgtttct tttcttttat tgttcttaaa 37380
ctgaccctga agcaaaattg ttagtcagca atcaatcaga tgtattatgg gtgcccttga 37440
aaataatcac ttgaggactg tacttcatgt aaaaaaatac attttataaa catatcagta 37500
tgtaagtaca ttcttctggt aggtaaaggc ttaatcattt actctatgct aacatattat 37560
actaccacat tacaccatac tgtattgtac cctaccatca tgtaccatgc cgtgcagtac 37620
catatcattc taggtatcaa caaggaacta tggtagcaat actccggtag tttctaggtt 37680
gaatatgatt ctgttttgaa catgctaagt tgaggttctt ataagatacc taggtgtaca 37740
tgtattcatt tattaactag attatattca ggttttttag tggcaaagat gtacgttatg 37800
gcaaatgtgt ataatttagt gtccaattaa ggatagcata ttgcatctag tgtatgtatc 37860
ttaagtttct tccaatttat tactgtacat tttctctttt actttgtaac aacttgttga 37920
agacgttgaa ctggttgctt taagaaaata ataataaaga cccagttact tcaataaaat 37980
atcatttgac ttgttgtttc ttgagttact gctagtttta gaggaaataa tgtgaagttc 38040
tttaagaagg gatataggcg aatagggaag tatacagagg agagtgatta gggagataaa 38100
agcacatcaa aaagagcgat aaaaggaact gagattgttt tatttgaaga agagatgact 38160
caaggggata tgaaactctg ttaaaatcta ctcacttaca accagtaaca gtaataatac 38220
taaacgaaca tggagaactt aaaaagtatt agtcattgtt tgaagtgttt taagtatatt 38280
aactctttca attctcacaa tactccatga ggcagatatt attattatta ttattatttt 38340
ggtattgtat ggacaacaaa actgaggcat agaattgtag aggtttttaa ggtcaggcct 38400
gatataacag caccagattt tcagcgtatg caggctgact ccagagtagg cattttaaaa 38460
taaatgtttg tgcaacaaat ttgtcctgaa caactgttgt atttaaagca ctatgtctag 38520
aatccttaag gtctggggag atgatgaggt tatggacact gctctcaaaa aaatgtacca 38580
tctgcacaac ttaaaggact gttatgtaga aaggagatta tatccatttg aatagtagga 38640
cctcaagtga tagaacaaag actggagaag aaatttacag gaatgttcat ttggtcttaa 38700
tataaggaag atgtttagta agacccatta catgtagcat gatgttttta ctactcaaac 38760
aggccagttt tagtgatcac attttcttaa ggcataatag gcagcctcag aagttagtgt 38820
ggtcttggtc actggaaatg atacacagag agtttaaggg acttgcccca gaccacacga 38880
ctgcagtgaa tgtcagaacc tctttgaata cattttaaaa taaggactga aagttggagt 38940
agggtggtta tcaaggctgc cttctttacc atagtattcc cagcatttaa caaaatcctt 39000
ggcatgtaat tggaattcaa attcttctta aataaatgaa aaacctgctg tagccagctt 39060
atagtttgta ttaatgtaga ttattaaagt ggaagatttt aaatgattgt ttgttaacaa 39120
ttatgtctat aatcttaggt ttggaaaaca ttattcattc ataatatttt tacttacatg 39180
ttatattaca tttttgactt gtagtgtttt tagcatagtt caactatagt gtagcttaat 39240
aaggaatatg attttttaaa aataacaatg ctattctata gcctttacag gacttctaaa 39300
aaacgacatg ttctctacca ctttaatact gaaactcaaa tcttattttt tgccacgatt 39360
attccagcta ctcttttttg actacttttc atttctgacc tttttatgtt gtagtccaaa 39420
taactttgaa cttttctcaa gttgtccatt gttgcataca aatcttccag catcttaaag 39480
cacagcctac tcacacaaaa aagtgattgc ttgccgcaga aaattgcttc accatcataa 39540
ttttttgcta cttcaaattc agtaagcatt cttacacatt atatttattt tatattcagt 39600
gatgaactat ctttatagat tccttaaaat ttcgggttat ttctttgata aggaaatatg 39660
tagtagaaaa aagtacaaca catatattgt aagattaatt atgacaattt ctagaaagta 39720
acagtctgtt caactcaaat gtttataaga aaagtctttc tttatttatt tatctgtgca 39780
tttaggcatg ccagaagaat ccagagagga tgcagaatct catcgtaagc taaatatggt 39840
taaaaaacag tgtttcaaga atgatattca caaactggtc ctagcagctt tgaacagggt 39900
atgttgaata tgagttttct gtctttacac tgttaactaa agtattaaat ttggagaact 39960
agggggcttt ttcagtcgaa gttttctatt ctccatttac tatgatagca ggaagtcatg 40020
tggttagaga cataagatgt gggaagtgaa aagatacgta ctaagctaag tccagctaag 40080
tgtattatca attgcaaatg taggcaagat tcttttgatt gccagtaata taaatccact 40140
ctagtttgct caaccaaaaa gagaaccaaa gagccagata tgcagctaga ccttatgagt 40200
catgctgggt gctatggctg ctgttttctc tgtctgtcct ctccggctac ttatctttct 40260
tttctggtct catggtatat gatttagccc atgaagacat accagggtta aaagtaaagt 40320
cttcgctggg cacggtggct caggtctgta atgctagcac tatggcgagg ctgaggcggg 40380
tggatcacga ggtcaggagt tcgagaccta cctggccaac atggtgaaac cctgtctcta 40440
ctaaaaatac agaaattaac tgggcatggt gatgcacgcc tgtaatccca gctactcggg 40500
aggctgaagc aggagaatcg cttgaaccca ggaggcagag gttgctgtga gctgagatgg 40560
tgccactgca ctccagcttg ggcgacagag tgagactttg tctcaaaacc aaaacaaaaa 40620
cagaaacaaa aacaaacaaa caaaaacagt aaagtcttct ttgattccct gtgctccttt 40680
tcattgctct cctaagagat aacctctgaa atgatttggt atacattgtt tccatttatt 40740
agcatttata tatctatgtt cctacgttat aattaaagta tcaataaatc atactgaata 40800
tgaaaaagag aaaaagggaa ttaaatttaa attgtgtaat gcaaaaagtt ttggtggaat 40860
taagttttgg aaattttgca taaaatgcat tggttcttta ttaaagatgt taagaataaa 40920
gacatgatta gtgtgaacgt ttttataaaa ggaggagcca atttaaagta attaatggaa 40980
atgattccat gtgtttgata tactttgata aatgtcataa attaattaaa gtagcttcca 41040
aagagatctc ccttaaaaat tcattttaaa gtgaacttta taatgtcact cactgcctat 41100
aatatgtttg agtcatttat actcaaactt taatacagtc cttgagtatg gcaagaattt 41160
atgttgtaat gggttaaatt taacttgaga aatatttgtt gaaaataagt atatggaagg 41220
aagcggttag gcatttagaa gataaataaa aatgctttgt acccttctct cctgaatctc 41280
ataatctggt tattgatgtc tgttgtgaaa ccttggttct tttctgtaaa caagagacac 41340
acagcagagg agatgcagca tcgagtaatt tattgcaaaa gaaagaatat tttgcaggtt 41400
aagtgaggaa tagacactta ccctgacaga attcagggcg ggcttgctag taaggaggag 41460
actgcataga ctggcactag gaagactcca tttgtgggag tcatacatga cttttcataa 41520
gcaggtggga agacgtgtta ctagtaagca tattctaggt tgtcctctgg gtgcacatgt 41580
gcagtagctg tacatgtttg ttcatatatc ccatgtctca taactctctg aaatctccac 41640
ccagcggtgt gtgttttact attataatga gcaaagggtc agtctgagga caggaaaatc 41700
aaaatgtgca tgctccctac aggggcaatt ccctactgga gatagctttg cttgaatgag 41760
ctggactaca atgcgaatgc tgaaacttat tatgttgaca gtaagattgc cacagttgcc 41820
gcgtcctgaa gacatggtta cttcctttta atacctatcc tgcctcattg ttagaggaat 41880
aacaactgtg cataaaatca gttgttctac acgagcactt aggagggata ccagcattgt 41940
gaacatagtc taagtacata gaggagggaa cagttaattt tattcatggt gagtgttggt 42000
gaaaagtgga agaggtacca aaaaagccat atatataact ggttccagtt agccaatatt 42060
ctctaaagtt attagagaag cctaagtgag atgtaacctc agcagtcggg agccaagaga 42120
gcaggtaagt gctgtgatgt ggagaaaatc gctttgttcc atctgagaag aaatggttga 42180
acactgcttt tccccccacg ccagtacttc agtaatgacg cacagccttt cactcagcac 42240
tgattatcgt tagaggtggc gagttaaggt catggagaaa cacaagtaac aatattttat 42300
ttcaaagacc tctccagtgt aattccccta atccttcacc atggttgaga aaaatggctc 42360
taagagatga gagtgattac tgtagctcca aaattctgtg attgcatgtc ttactctgaa 42420
tagtaattac aaagcatcag aggttttagg tccaaatatt gcagacacga taaaatgaat 42480
tacattttaa tacatctaaa cttggagagc agagttccaa ataaggtaga acttgagatt 42540
caactctgat ttataaagca gactaagaag agtatttatg aaagtgaatc catgtttgga 42600
tacataaaaa tgcaataaaa ttcaagctga agttaaaatc tctgtctaga acagcgatgt 42660
tccatttatg cctgatcctt ttagcttttc cacagatgaa gactttgtca cctgttccag 42720
agagatatat ttgtccatta ttgtttccag agagcaaagc agaaaataga ctctacacat 42780
tttggctgca tctgtgtttt atatgtggtg acattcctgt gttcttcagt gaggaaatcc 42840
agtaaagtaa aacaaatctt cagatgaaat gggcacaaat cagagaactt gtgagcttca 42900
caaaaacctt gaagcaaaat atactcagct taaatattga atatatttat ttcagtagtc 42960
aaaaaaagag cttatctgca aaagcaacac caataacaat aacaacaaat tgcatataag 43020
taaaatttat aaaaggttta caggatggat atacagaaaa ctacgaagct taggggtaga 43080
gaggagtagc tgaatgtatg agaagataca tcttctattt tgataaaagg actaaatttt 43140
taaaaatgaa aattgatcta tgtttatgga cccttagtaa aaataacaat agtattttct 43200
ggaactaagt aagctagtgt aaaatttgca tgaaaaaatt aatacatatg agcaatcagg 43260
agaattttaa acaagagtgt taattcatat ggcctaactc caaaagataa tcaaatgtat 43320
tatacaattt tagtaactat aatggtgtga tactggcact agaggagaca gatcagtgcc 43380
acataagggt ggctcaggaa atagacttaa ataaaaattt gtaatgttat gatattcctc 43440
gactgctggg aggaaaatag attactcagt tacttgtgtt ggaacaacta actcttcagc 43500
catttgggaa aagcaaagga agctgaatat cttactcctt ttgccaaaac aaattacaga 43560
tggatgagat tatggtctaa atgaagttgg tatatgtaca cattaaaagt ttcaactata 43620
attgttatta acgtaaatga taacgaaata gcttgttgga gagaaatttg gtaatattta 43680
tcaaaattaa aatgccatat tttctgatca gcaatttcat tctaagaatt tttaatgtag 43740
atatacttgc tcatgtacag aaatattatt agacatgaat gttcactgtg gcatgatttg 43800
taattaaaaa tgtggcaaca aactaaaagc ttacatgata atcattcatg ctgttcgcca 43860
aatattttta gttctccacc ttccggtgat tctggcatag gatttagtag ttaggttgaa 43920
gcatgtgact aagtttggtc agggagttgt aaatggaggg agcactgtct caggtatgtt 43980
gacctgcagt gtttaagata gtagttgctc tgtcagtgga ggtccctgag ggactacaac 44040
aagcagagtc ccctcctgac ctgcaacaca tatgtagcat gagcaataat ggagcttatt 44100
atttttgcac cccataaaat tttgagaatt gttactgcag cttaatttaa tctttcctga 44160
caatgcagta ctcatcaata gagactaatc agataaatta taccatttcc aaattatatc 44220
atcctacata aatattaaaa aacaatgagg tgagattcct aatgtgctgc tttggaaaaa 44280
tcttcaattt tctatgtgta tgaatgtatt ccccaggtat tcgttttttc cttcctgtgt 44340
gttgacacct tatgcacact tttggctgaa attaatatat ttccactgct ttatgtcctc 44400
tccctcgctt ttatcaccca attgtagcaa attatatgtt cgcttttata gctttagcta 44460
tgtaaaattt tctaatagct aagtttgtgg tttctggaat taagacatct gaatttaagt 44520
ctgacaccac tacctacaga ctctgcaccc tggacaagta cttaatgtct tggttttatt 44580
atgtataaaa tggagataat aactgatttt tcagttagag ttgttgaaga ttttataaga 44640
taattcatgc ggaagtgtca gtataatgat tggcacatag tacgcactca ataaatgtta 44700
atgttattgc tattagattt aaaagtatgt tttgactcct ggctatataa gatgagagta 44760
tttgcacttc tgatatctcc tgttttccca cctacttttt ttcaataaac taactccaca 44820
ttggcagagt agataatatt tatattcagc tttctaatta tgctttctaa gtttgtgttt 44880
accttattcc tacagttatt tggaagcagt cttcatctca agtccttttg ttattgtttt 44940
tccattcatc ttttagttgt ctgaatttct ttagaaaagt ttaattcctt gaatatctaa 45000
tgtttatatt tcattgttgc tgtttttgcc tttataaatt ttgcactctt aaaaaaagtt 45060
atgttggttg taaaatattg tttttttttt ttttccctga agtgtttgta ggcatttcac 45120
tgtgttctag tactgaatgt tttagtggag aagtctgaga ccagcttcat ttgtttctta 45180
ctgttaagtg cttggattct ttgcctggcg ctgaaagaat tttttctctt gaaatctatc 45240
cactttagta ggatatatct caatgttagt cctgggatat ggtattctca ttctagctat 45300
acattcaact ttttttcctg ggaagtttta ttgaattgca tctttatata catgtatatt 45360
acatatacat atacatatac atggtaaaga tattaaggat aaagatagat gctttataaa 45420
tatcaattcg atataatttt ggcgtgaaaa taagcctgtg gtgcattttg agtttggaag 45480
tagaactgga tatacttact tattattatt tttaatacaa aagtggagac agggtctcac 45540
tatgttgccc aggctggtct caaactcctt gactcaagca atcctgcctc gacctcccaa 45600
agtgctgaga ttacaagtgt gagccaccgt gaccagccta aatatctgta tttttctctt 45660
tcattatttt agctctcttc tttgaggcta tcagtcatat gatgttggat ctcttttgcc 45720
ttaatctttt aatttttcaa agactaatcc agcgacacta tcaccatgcc acttacttgt 45780
agacaaggga gatgattcca aacatttagc ttatttatca aaatcagaga tgggatttat 45840
aagaaaaaaa ggataaaggg agaaaacaaa acacaaatta tctgggaacg tgagtctgtt 45900
ttcctttctt tggctaatct acttacctag tagctaggaa agaggccagc gtgagtattt 45960
ttccattgag ctggcaagct cactcattag agaaaccatt tcaatattta tggattctct 46020
gaaaaaaact tggagagtag taaagcatag gtggtaggat gctgccatcc ttctgttggc 46080
atctccagag tttcacttga aaaacacctc ctaagtagac actagtaaat tgattttaat 46140
ccctatttga gcaccagtgc aatacgttac tattgcaaga tggagcatta gataactgaa 46200
ggaaattctt ttgtgggttt gtaaatatca cgatagtcat acctacataa tacatatatg 46260
tatatataaa tattaatttt taaacattta cttagctatt aaaaatcaaa tgctcatatt 46320
taaaattatg agtttatact ctgaattctc tttttgcata gacaaatcag agattatctg 46380
ttacaagtca ttagtcatca ttgacctgga ctgaaatggt tagagcctag gggagttcca 46440
ggtaaaagga ccagtaaatg agtagaaact cgttagatgt agagctatta aggacaaagg 46500
gaggtgcttt ataaatatca atttgatata attttaacat aaaaagaagc ttatgatgca 46560
ctttgagctt gggagcagaa gtggatatgt aattgtgtaa taaaatggaa atgcactctc 46620
cttgtttgaa aattattaag gattttacaa gggtgatgac agagcattga agcaagtgct 46680
ctctgagcat gaagccgtat atgattgtac aaatacacac ctgtgaagct ggccttgcct 46740
gtcaaacagg aatgttggtc ctattaatcg aacagaaagt tcagaatgac aatctgactt 46800
tgttttgtag aagatactaa gttttggcct tgaatatttg agttaagata ctggtatcaa 46860
gcaaaaataa atttgggctt agaactttag agagtttaaa cttgtgcttt gacttgtgtg 46920
ctcacatgtc tctgtgtcac aatttttttc atccgtacat caggacaaca atagtgtgtc 46980
tacatcacaa aggttttggg aggattaaga aggtgaatac atatgaagta cttaaaagaa 47040
tgtctggcac agagcgagtg ctacataggt tttggcattg ttattgtggt cattgctatt 47100
gttattacga cctgaagtca tcttagtgta tgaaatccca catatgaata gaaaatagaa 47160
agaactttgg gcaaggtttg gaggtgaaag aagagatcgt aaagaagatg ggtaaaggaa 47220
tggttttaaa gattgagaat aattaggggg gtactgtgtc atggaaatta aggggtgaaa 47280
agcaccaatt aagttgttat tagacttttt tctttggttt atgttcagaa tggctaggaa 47340
agaagtctga ttataggaaa ttaaagggta aggcgaatgt ggaggtagtg ggagtcgact 47400
tttctattga taagtttaga aataaagaaa aagtggtaac ttgaggaaag agaggaccaa 47460
ttaagggaaa gtctctcatt aactctgaag tttttcatct ctgaggacag cgcttagccc 47520
caggcctgac ctgtgatgat tgctctctcc aggtctgttc catggacaga gccatctcat 47580
ctcctcccca tcacagcctg cattaggaga attgttttaa ggatgaggga gctgagacac 47640
agcaaaccag ccttccaatt tcacttcgca cgactctgaa tttctttata tttcttgaat 47700
agaagtttca ctttttactt accacttctt agtagtcatt gtctgagtaa ttgttacttc 47760
attcatttaa tggttctcag atttatttaa tggttctcag attcacagaa tttaaaccca 47820
aatttaattg gcctccaagc tgatgtgctt atggaaacag tgacaggaaa caaaaacgtc 47880
acgggagaca atgtcttatt aagatgatac atgaaatgat gtccaagctg agcaattaaa 47940
gtgtgaagtg gaaggacaca gggtgagaaa ctgatacttc tcagcctctg taaagaagat 48000
aatgagtaaa gataattgag aggcattagg ggagtagact gagaaaggga tagaaatctg 48060
ttcactgaga gtacagaaat gaggaagctt ggaaggcaga agatttcggt caaagacatc 48120
cggcttgaag ctatttcagc tctttggatt atctgtggtg gaggccatca cgtctttgga 48180
gtggaggtac catgaaacga gtgtctgcaa aacatcatct aaatgaaagc aaaattcctg 48240
ggaaggatgg cattataatt tttgaaagaa aagctatgag ttgagcattc acaccaaggt 48300
agatgtttgg agcgtattgc ttgtgtgtga aaaggcagag atgaccagaa taagagttag 48360
atgtatgttg cattttcttc ttggttgatg agtaggatgg tctggacaaa gaagtgacct 48420
gtattaaaat acctttataa tgtcaaagca tctggaggaa attcagatta aagaggttgg 48480
atgatgttgt aattaagatc ctgggctttt aaggtggaaa catttatatt caagtcccag 48540
gcccagtgcg tattagttct gtgacttgag ctcttacttc tgcatcttca aagtttggca 48600
aacctattac atgaagctgt cgaggagata aatgaaataa ggcatgcaaa gaacttgcag 48660
tgaagagtaa ttatcaatat tttctttgtt gagaggcagc attgcgtttt actggtcatt 48720
acattttact aactattaag ttagtgtgga ctttgagaat agttctcaac cattctaacc 48780
ctcagtgaat tcttcttcta atgggaatga tatcagtatg gatttcatga gattatgaaa 48840
agaaaatgcc tacaaagtat ttattacaat gcctggcaca gagcaagctc tcattaattg 48900
taaaaatgct aactcttatt cttcataatg cataaacata attaatatta tagaaaacaa 48960
aatcaaggat actaatttgt gtttggatta attgatttat atttcatcag tctataactg 49020
gtcttaacta aggtaagtat taagatctca tttttaagag caagtattct tttgatttca 49080
gttcattgga aatcctggga ttcagaaatg tggattaaaa gtaatttctt ttattgcaca 49140
ttttactgat gcattagggg tgttatccct ggaaggtgct gtggattcag tgcttcacac 49200
actgcagatg tatccagatg accaaggtca gtacaatttg aattctggat ttagaataga 49260
tttttgtagg ccattagctg gcgactggat gtctgtaaat atttttcttc agttttgaga 49320
tttaaaacaa ttcttttttt tttttcttct agaaattcag tgtctgggtt taagtcttat 49380
aggatgcttg attacaaaga agaatttatg cataggaact ggacatctgc tggcaaaaat 49440
tctggcttcc agcttatacc gatttaagga tgttgctgaa gtacagactg aagtatgtgc 49500
attatcttgg aaagaacttg ggaacttgtg caaatttcac ttttggagca gttcgtgtaa 49560
ttcccacttt gcatgaatgg ggtattctag ttaatggaaa accatttatc attttgtagt 49620
tattttaatt atacaagcaa agaaaattgg attgaatctc taaagatcca gtgtttcatt 49680
attaaatctc taaagtcagc atgtttattc accatttatc ttgcccataa aagttcagag 49740
actgtgctta gaaatctcag ctagagctga atttattcac ttagatttta gataaataga 49800
atttataaat attccaaagt ttgtcactct ctggttttat tgtaggttgc ttacctctaa 49860
taatttgact tgttaatttt tttccttgca gtgaaaaaaa tgtttttaac atttttcatc 49920
aagcaaaatt taaaacatga tatataataa ctatctttat aaggaattca agatattggc 49980
ctagagtgag ttcaggggag attaagaaat aatttttttt ttaattgtag caaaacaaat 50040
agcttttctt caagagtttc tgtcttagtt gtggagtttg caactttcat aaactacact 50100
aaggaatttt tttttttttt tttttttttt tggagacagg atctcactct gtcacccagg 50160
ctggagtgca gtggcagatt tcagctcact acaacctctg cctcctgagc tcaagtgatt 50220
cttgtgcttc agcctcctga gtagcttgga ctacaggcat gcactcccat tcctggctaa 50280
cttttgtatt ttttgtagag atggggtttc accatatttc ccaggctggt ctcaaactcc 50340
ccagtctcaa gcaatctgtc ctgctcagcc tcccaaagtg ctgggattat aggtgtgagc 50400
caaggtgcct agccgactca ggaaatattt tttgtaactg gcagcattga ccaggaataa 50460
aaatacttgg tctctaatct ttgcacagac accatcagta aatgagagaa tgtgtataaa 50520
gtgttttaaa aaattatgaa gttaagaaca tacaaaattc ttacattaat aacaacaatg 50580
tgttttataa ctgcttttca taatgtgcct caggataggc tgattagagc aagataggat 50640
tgattaaaag taatcttaag gaaaggaaag gattttatgc gggtatggaa ctctcagtca 50700
ctctggatta attcatctag gcattaattt tagaatctct acagtagagg ttatgaacta 50760
aatctgtcct gccaacatat tttatttgtc cagttcagtg ttttatttta ttttttgaga 50820
cagggtctca ctctgttgcc caggctgtag tgcagtggta caatctcagt gcacagcgcc 50880
atccgcctcc tgggttcaag caattctcct gcctcagcct ctctagtagc taggactaca 50940
agtatgcacc aacatgctcg gctgatgctt gtatttttag ctgagagggg ttttgccgtg 51000
ctgaccaggc tggtctcaaa ctcctgacct caagtggttc gcccacctcg gcctcccaaa 51060
gtgttgggat tacaggcatg agccactgca cccagccttc agttcagtgt ttaaaagttt 51120
ttaattcgat tgatgtactt tctgcacatt tgcatgacct gctctgctgc agcattcact 51180
agttttcagg gacctctggc tctagaggca ggtagaccac ctgtccctca gacatacata 51240
aattaaggct actttgctta tcaaatatta gtatttgtag aaactcagta tcataagagt 51300
ttgaagtaat aattttaata tttagatgat ttaacttaat ttaaattttt tttgagatgg 51360
ggtctctgtg gcccaggcta gagtgcagtg gcacaatctc ggttcactgc aacctctgcc 51420
tcctgggccc accctcctgg gtgggctcaa gtgatccatc tcattctcct gagtagctgg 51480
gactacaggt gcacgcacgg ctaattttta aatatttttc atagagacaa gattttgcca 51540
tgttgtgcag gctggtctca aattcctggg ctcaagcaat cccagagcgc tgggattata 51600
ggtgttagcc acggtgcctg gccaatttta ttaatatgta attttagagg taataaaatg 51660
ttaaaaagtt aagatgatct ttgggtttac ccaagctaaa taatactaaa gtcaaatccc 51720
agtctttcat taaaacatca catgggtgaa gaggacagac tctggggatg tgcttaaggt 51780
ggttctaaaa aagtaatggt gttctttata aataacttat tattataatg taatcctcag 51840
agtgccctca gtgcttctct attacactca acataaatga aacctaagag tccacgctag 51900
cctttttgag gtaaacattt cagaagacag cacagaaagt tgggggatat gctaggctct 51960
ctagagaacc tactattcat attataataa aaatttttac tctgttttcc tatttggatg 52020
tgtagctctg ctgatccaac tgttttaatg ctgtttaata tctgggtttc atcctacaac 52080
tatggcttta gacaagcatc tttgaaaacc aaatttgagg ggattagttc ttttttctgc 52140
tttgctactg gatggttaac tagcatttta ttctttgtac ctgctatatt tcttagtcat 52200
gagagagaga gggagtattt atttacagga taaatacttt caagcaccaa cccagtatat 52260
ctatagttaa atgaacatcc taggtattgt ttcatataca aactctctgc tttatactgt 52320
ttattctttt tgcctataat tgcttagttt attatttttt tcttatactt ttagggattt 52380
cagacaatct tagcaatcct caaattgtca gcatcttttt ctaagctgct ggtgcatcat 52440
tcgtttgact tagtaatatt ccatcaaatg tcttccagta tcatggaaca aaaggatcaa 52500
caggtacagt gttttccact tgcatcctaa atgttatgta tttatctgac tctaattctc 52560
atttccactc tttttagttt ctaaacctct gttgcaagtg ttttgcaaaa gtagctatgg 52620
atgatgactt aaaaaatatg atgctagaga gagcgtgtga tcagaataac agcatcatgg 52680
ttgaatgctt gcttctatta ggagcagatg ccaatcaagc aaaggaggga acttctttaa 52740
tttgtcaggt aaatattaaa ggcctcactt gtgtctttgc tcattattct tatcaaatgt 52800
aagagccctg ccgctgtgta tctcttactt acatcatatt attcttcact acggaaattt 52860
accagtttat tgtaattgct tgtatcttgt agtagggatt tagatttata gaattccaga 52920
agtaataggg tcctttaggt gttatccagt ctaatctttc atttcatctg ttggcttatc 52980
ttgttaagtt gataaataac ttttcaaatg tgtcccttag taggcatctc tacaacttgt 53040
tctccagata cactccacat aacacatagt tctaatattt tgataatttt ttaaccattt 53100
ttttccatgg ttttagtttc tttgcctaca aagttctcct ctgagggcta ccacacatga 53160
ctatgcaggc tgtgaatgtc acacttttgt gggtgccatt cacactgaca tgagttgcta 53220
ttggccaaag ttgtgtagta gtgtggtctt tctttccttc tctcttccct cctgaaccat 53280
gcaaacatat atctgtctga ttgttttgct cttccttcaa aatataattc aaattgcctt 53340
tctttaataa agccctcccc atacctccaa acaaaattaa gatttacttc ttctgtcagt 53400
tcatgaaaat atatacatat ctcttgtgta cttggtgagt tgtgtgaaaa taaccatgta 53460
tagtgttcgt ctttgtatga ttcagaatat ctagctcatt gctttacata tagtgtatat 53520
tctaataaat actaagttca ttgcttgtat ttcagatttg tattatttgt ataagtgtta 53580
gagtttatac tagcattcag gtagcactat gtctattttc tagaaattta acatttctaa 53640
caaatattaa atttcagtat ttaataatca gtattattat cagtaaataa tcagtaaagt 53700
actacgtttg ccaataattt actttttaag ctttactgta tttaatatcc cacttgccta 53760
tgaattgaag ttaatttgtt gactgttaag attaagttaa tactaattag taatcaacat 53820
aaaaagaaac agaacgtgga acccattttc atgcaccatt atgtttatgc attaaaatca 53880
cataaacaat ctaattattt aaatttagtc aaatttcttt taagcaagca aaaattaaaa 53940
tagtagttct actttattaa agataattaa atttttccat caataattta atacattttt 54000
atggtgcatc ttttgcatgc agattattgc attaatgtta attgaaaata ccaaagaact 54060
aaaaagaaac ttccccttct aagtccacat taaggaaaca acatacctaa aagctcctga 54120
tacaacttta ctgcattccc cacaggaaat catttctgct cttctttcca tttatccaaa 54180
tcttcctata caacaggatt tttactttat ttctctttcc atattctttt ggccttcata 54240
tgcttatttt tatcttttct tttcaaaaca aaatcttaaa tccaaggatt atgtatcaga 54300
cttaaagaat ttatcccagt tgtcagaagt tatttatacc tagcaaataa taactgctga 54360
ttaaatcttg tggatgaatt tattgtatgt accttatttg tgccagagca aaataaggta 54420
atgaagacta ttcatttaac aagaggttgc atgtagaagg agtatctagt gcacgggtgg 54480
agttgtgtta ggctttctgc agaaaattta ataatggaat gtacatgact ggtggagaat 54540
aatatgaaag gttaatactg gatatgcaaa tgcatggata aaaacctcaa ggtaaaactc 54600
atcaaatcac agtggaaaaa gtatagtgaa gtctgaatga aaataataag aggctgggca 54660
tggtggctca catctgtaat cccaacactt tgggatgttg aggtgggagg atcacttgag 54720
ccaggagtta gagaccagct tgggaaacat agtgagactc catttctaca aaacaaaaca 54780
acaagcaaaa acccatgtat gatggcacac acatgtagtc ctagcttcag gcagagtggc 54840
tcatgcctgt aatcccagtg ctttgggaag tcaaggtggg aggatcattt gagcccagga 54900
gtttaagacc agcctgggca acatagttac actcccatgt ctacaaaaag tcaaaaaatt 54960
atctgggtat ggtggtacct gcctattgtc ccagctactt gggagtctga ggtgggagga 55020
tgacttgagc ctgggaggtt gaggttacag ttagctgaga ttgcaccact gcactccagc 55080
ctaggcaaca gagtcagacc ctgtctcaac ataacataac gtaatataac ataacataac 55140
ataacataac ataacataac atagcataac ataagaatgc tgaggcggga ggatcacttg 55200
agcctaggag gtcaaggctg cagtgagcta tgattgcact gcggtactcc aaccttgatg 55260
acaaaagcaa ccaactaacc aacaaacaaa aaaacaataa aaccaaacac ctccatcata 55320
tgcattacca gctaggcact gctccaaata ctttacacaa tttaatccta acgacaacct 55380
atgaataggt ccagtagatt ctaatgttat tcccattgta caagtgagaa gttgaggcac 55440
tgagggatta aataacttgc ctaagaacaa gctcctggta aatagtgcaa aatctgcctc 55500
cacagtgcct gctttgattt cttggctaca cagcagattc atggtagtgg tggtagtggt 55560
gttcatttac tctaaaataa cagtttaaat aatttgattt tgataatgtg ctgcatttat 55620
tataaattag atgatcagag aaagattgca gggataagaa attatgcttt tgataatctt 55680
tagttattat attctgaatt ttcttcatta tttaaatgtg aaaataaata tctgtaagca 55740
gtagtatttt cctgtcatga agttgaaatt actttcataa atatgtgtga atattctaaa 55800
gagaatgact ctgtaggatt taaagaaatt aattcttatt tttgctgaca tttatttctt 55860
ttctcagatt ccctttctta tatctctctc tcttcatggc acccatatgc ctaaagtcag 55920
cttggatagt ttggatcctc caaggaaaat tccttccaca aacatgtgca gagcacagtg 55980
ctagataatt aatagagaat atataagggg tttcctgttt caagaagttt ataggtctgt 56040
atgtgttggg acattgacaa gagaataaaa cataaatcac cttagtacaa agtaaggagt 56100
gagtggctta tcctagagaa aaaaagttac tgggctacag gagaaggcat ttgtgagttt 56160
ttcccttccc tcccctcccc accctccttc cttctttcct tccttccttc cttctttcct 56220
tccttccttc cttccttcct tccttccttc cttccttcct tccttccttc cttccttccc 56280
tccctccctc cctccctcct tccttccctc cttcatcttt cacctccctt ccttttaatt 56340
ttgctgtgag cccttaaaga ggattttagt aatttactac ttaaattaaa tatacgtcct 56400
aggtgttgtg ctaggcttca ggaatacaag ttgaattgca gtaatgtaca ggcctttgca 56460
ttctagcaag aaaacagatg ggtgtgtacg tttgtttcct cagtgctaca ttaaatgaaa 56520
tggatgggag ccaggagggg aaatagtgtg tttggcctga gaggttagta gcaaggactt 56580
ctccacaaga aattttgaac ccaattcttc aagaatgaac acctttttgc tgggtgaaga 56640
gtagaggaag gcatttgggg taatagaaat agcacaaaag ataatgaggt ttgaaaaatt 56700
acatgctgtg tttggaagaa tgtccggagc agtggcattt taggttttta aagaggacag 56760
tgacttgatc agagctctgt agtgctttga gtatgggttg aaggtgagtg tacttggaga 56820
ctggtgggca tttaattggt gccttccaac cacatgaatg aatgtcccct taaatccctt 56880
ggaagcactt tgatcctaga aaattcaaga attgtcccca acatcttttt cctctgagtt 56940
ggtaccctgg atctttgggt cttcttttct ttcctttttt aatgtttaat tttgggtaat 57000
gaaagtcgca caggttttga agccagcaga tttggcttca aatccaagtt tcagttgctt 57060
gccagcttta cgggacaaat tatatatctt ttctaaatac tcatctatta ggtgggagaa 57120
ataattgcta tggcataaga tttttttttt taaagattag aaatcacatg tgtacagaat 57180
ttagcacagt aactgatgga tattatttct attacctgtt atttttgtct tctagttgat 57240
agctccttgc taacgtctag ctcctttcca aagctcttcc tgagtagggc cagtgtgtag 57300
tgctgcaggt tgctaaggct tctcctggct tgctgagttg ttctagtttt tgtagcacct 57360
tgcgtgctaa cccaccccga gcacatgctc tgaaaacata acattcagag gaaggttgag 57420
gactgagaga caaggtatat ctttgaggaa attcagatgc ttgtactgag gagatcagga 57480
aaaccagaca cgagtaatga ttgtcgtttg tgtgtggcat taataaattt tacaatagct 57540
aagtcctcat ttagttattc tatgtcacag ataaagacag gacagtagta tttactgtgt 57600
taaggtactg gtttcccaga tatcttacag tgagaagaca gaagctcaga aagtgtaagc 57660
aatgtgcata cttgttggag tctggatgta aacagagatc ttgatgccaa gcctatggaa 57720
ctttgtctcc atataatatt gtctctttca tggataactg actgccatgt ggcagattat 57780
tcacgctatt ctgacagtta tggctttaat atcatcttat tttcccaatc tattcaagga 57840
tcagttttgt cttattttat tttgtttaat tccaaattgg agatgtagag aaaaatcaca 57900
tgacgtttga tttgccagtc tcctaaaaag aagaaaacta tagattttta atatacttaa 57960
tttttttttc tttaacaggt atgtgagaaa gagagcagtc ccaaattggt ggaactctta 58020
ttgaatagtg gatctcgtga acaagatgta cgaaaagcgc tgacaataag cattgggaaa 58080
ggcgacagcc agatcatcag cttgctctta aggaggctgg ccctggacat ggccaacaat 58140
agcatttgcc ttggagggtt ttgtatagga aaagttgaac cttcttggct tggtccttta 58200
tttccagata agacttctaa tttaaggaaa caaacaagta agtaacaagg agaatatttt 58260
tgacagttct tatttttaat agtatttttt taagtcacta gtcttttagt ggttattcat 58320
gccagtttga aggaccttaa gccaaaaata ttgcaaaggt ttggattttt ttggctatga 58380
aatacttcaa aatgatgtat ttaagttctt tatgagatag caaataggta cttataaaat 58440
tagagcaaaa tagcggaagc tttttgaaga gctacttttt aatatagtcc ttttttattt 58500
ttaaagtaaa gcatccttgt ttttttaaaa aaatataaaa ttataaaaaa gaaaataaaa 58560
ataacttatt ttttcccttt taagtaatta aaacggatat ttttcctaac tttttgtatg 58620
cttacatgta cctatgcatt caaatgtatg taaaagcata cacacatatt cacttggcat 58680
ttttaactta gcatatatat atttcaattg ataatgcatt ttctttatac attcaagctc 58740
atatgtattt tgtacatatt atgtgtattg atggtaagtt gccatcctct gacactgttt 58800
ttgtcttttg agctctttca tttgttcaca ctaaatgtgt ttttagcgtg tgagctccca 58860
gctttttcta tgttaattta gtctcatgcc catctccttc cccatggtca tgatactcca 58920
tgactcaaca cctttaggac cattttgcaa atagcatgtt tgcttctctc atttttatga 58980
tgcactcaat agcaaaacac cagttttggt cagtctacta gtctactttt tccctcactt 59040
tcaccaagat aactgagtgc tgctagagaa aagtacccgt ccatgcaatt tggtgccttt 59100
atacatcaag gtttccaacc tctcagtagg ctccaaaagt tccagtcagg ctgaattttc 59160
ctcggtttct caaacacttc atgtaccctt acttccagtc tttttccatt gttactctct 59220
ctacctaact ctaaattctc tcttcacctg gctgtctctt cattcttcct gtctcagcac 59280
catcatcagt ctggaaggtc ctcttacatg accctatagc accttatttc tcacctatac 59340
taccattcac cacattatat aatttaattt ttcattttta ttatctactt tttggtagat 59400
tgttagtacc atgaagtcaa tgtcagtttt gttcatggtt gtaaccttac cattgatacg 59460
agtgctttgc acatagtaga ttgtcattta gaattaaaca tttaatattg gcaaaaataa 59520
aaattatgta atacattatg ttgctaagca tatgtggaaa catgcttcat acattgatat 59580
gaatttaaat tgtcctcttt tgaggacaat ttggcaatat ccactaatat tttttaatat 59640
acaaacatac ttttttgacc tagcagtgta ctgttaggaa tctatgatac agacattctc 59700
aatgtgcaca aaaaattatg tacaaaaatg cacattaaaa cattgtttat aatagcaaaa 59760
gagtagggaa aaacctaagt attccccaaa aggaactatt caaataaata atggtacatt 59820
catgcagtgg aatgctttgc aatcattgag gaaaaaaaaa acatatagca aatttaatgt 59880
cttgataaag attacattac tccatggcaa aaaacaggca cagaacagtg tttttactgt 59940
gctaatgttg atggaaatgc aattggaata tgatagttac aaaagtttga atatgaaata 60000
aaaccctcca gaaatggggt ccctgattgt ctctggggtc tttggaaatt actgagacat 60060
ggttagatcc catgtttcat tacttaaact agtctcatgc caaaaatctg cttactttaa 60120
tcttcgctgt ctgatagaga ggaattgtgg gcccattgga gaaggatgga ggagatttat 60180
cattcactat attccctttg ctgtgtatga agtttttacc attgacacat cttacccaat 60240
taaaagagca cagcaatgtc atttgattaa ttggagggta taaccatgat ttcattggca 60300
gctggtctga gtaaagaaca ctttgggtca tagctttcaa acatttttca ggtagtattt 60360
gcctgagtga catatatgtg tgtgaactca tcctgctggg cttcgggata atttcccata 60420
tcgtaacata ttactctgga aaaaaagaac tatttgggta tatgggtata gtgtaagcca 60480
cagtatcaaa tgtcttcttg gggtttatca tatgggctca ccacatattt acagtaggaa 60540
tagatgtaga tacatgagca tacttcacct ctgctactat aatgattgct attcctactg 60600
gcgtcaatgt cttttagctg atgagctaca cttcacggcg gtaatatcaa atgatccccc 60660
accacgctct gagccccagg gtttattttc ctttttacag taggaggcct aaccagcatt 60720
gcattaacca actcatcact ggatattgta ctacatgata cagtggtatc cttaactttg 60780
ttaaaggtag taatgttaat aagatatttg gtaaaaatgg agtgagggac ttttttgtta 60840
atatagtatg attgaaaaca ttggttgata gaataaggat atttgagagg gcaaaaaatg 60900
agagttgttc caagatattg tgtctcaagt caaaccattt ttaaaaatca agtgtagtga 60960
cttatataca tatataattt atataaaata aaatgcatat atataaattt tatatataat 61020
ttatataaaa ttaagtgtat attttcatgt gctttgaaaa ttaccactgt atcatgtagt 61080
aatatttgaa gtaattacag tagtaatatt tgaagaaatc ttcctggctg tatgtagaac 61140
aatgaggact ctgtcaactt attcttcata gtagagctga tatataatgt aatgaagttg 61200
tgagaagaat gttaattttg aaattccatc aaatttccca atagtcataa tgaatcactc 61260
agcaaacttt ataaaaataa caacatcctt tatttagtat tttttgtgtt ctatgcattg 61320
tgctaaacat tttatataca tggtttcatt tactcttttc cattaccata tgctgtgtat 61380
gttatcatct tcattttcca ggtgaggaca ctgacaccca tggagcttat ataactcaca 61440
aatggcattt ctatgacttg aacacaggcc tgtctggctt caaagcctag gccttttcct 61500
gaataaagtt ccatagagat tcaattttgc tatctacacc aaagcattgt atacatggtt 61560
atgttttttt ttaaaaaata tgatctgcca cctgctaatt atttaggatc actaatgtaa 61620
ggtgactttg gaaggaaaaa tagaaatttt ctctagaagc ataggaatac ataagaattt 61680
tggtcctata tatgtttatt tttgcataat tgttgatttc taagttcctg gtgcatctct 61740
ttattttcag atatagcatc tacactagca agaatggtga tcagatatca gatgaaaagt 61800
gccatggaag aaggagcagc ctcaggcagt gatggaaatt tttctgaaga tgtgctgtct 61860
aaatttgatg aatggacctt tattcctgac tcttctatgg acagtgtctt tgctcaaagt 61920
gatgatctag atagtgaagg tatttattat aaaaagaaat ccctttatgt tttacattta 61980
cacactgaca ttgaacaata ggacccgaga caaaaacctg acttaaatca tttggaaaaa 62040
cttaagtaga aatgtgttta ttatcacaaa cggttaggtt tactaatttt ggtcaaagtg 62100
atgtttcaag gaagtgtgtc tctgtgcttc taaatgttat tctgactaat tggttaatgg 62160
ttaatattcc aggaaataaa ctctgactag actggaacga gattccacac tctgacactg 62220
actaaatcct tttgtggctt gtgtaagctc cttaactttg ttaaaggtag taatgttaat 62280
aagatgtttg gtaaaaatgg agtgagggac tttttagtta atatagtata attgaaaaca 62340
ttggttgata gaataaggat atttgagagg gcaaaaaatg agagttgttc caagatattg 62400
tgtctcaagt caaaccattt ttaaaaatca agtgtagtga tttatataca tatataattt 62460
atataaaata aaatgcattc actttaagtg tatattttca tgtgctttga aaattaacat 62520
attcatgtag tcatcatcgc tattaagtta tgcaatattt tcatcatcca aaaaagtttc 62580
ttcatgcctc ttcactggaa ccgtcccctt cccctgcccc tgtcccttag caatcatttg 62640
cttcctgaca ctgtagatta atgttttctc tagttttatg tacatagaat catacagtaa 62700
gtactctttt gtgtctgttt tccaaagtgg ttgtactatg ttctccctcc accagcgata 62760
catgagcatt ctggttcctc tacatccttg tcagtacttg gtattttcaa gttaatttta 62820
gctcttctag tggagattta attcatttgg atgtaatttt catttcccta atgacatttt 62880
catgttctta ttggccattc ttatttttgt gtgaagtgtt gaagtatttt gcttttaatt 62940
gggttgtcct acaattacat aaaagttctt tgtatattct agatagaagt tgtgacaggt 63000
gtatatattg catatatttt tttcccagtc atagcttgtc ttctcatttt actaattcta 63060
ttatttttaa aaaacagaag ttttaaattt tggtgaaatg cagttttcca gtttttttct 63120
tttatggttt gtcctttttc tataccactt aagaaacctt ttcttagcct aaatttgtga 63180
atattttctc ctatattttc tcttagaagt gttaaaatct cagctttaac atttaggtct 63240
aaaacatttt aagctgattt ttgcatgtga tgtgtcaatg aagggttgac acttatttct 63300
ttctgtgtgg atatccagtt gttccaacat tacttgttga aaatactata taattcctca 63360
ttgaattaat ggaagctttg ttctctttaa ttgactattt aggtatggtt ctactttagc 63420
attatttatt ctgtgccact gatttatacc ttattcttat gccaaaacca cactgtcttg 63480
attactctgg cttactagca ggtcttgaaa tcaggtagtc caagtcctct ggtgttcttt 63540
taaaaaaatt gttcttatta atctagatta tttgcatttc catataaatt ttgaatcaac 63600
taactttatg ctgggatttt tattgtaatt aagtccatat ttggatttta tattgaatta 63660
atttataaat taaatcatat tacctgtaat gttaatataa tctataccat ataattaata 63720
cataaataat ttctatagat tatatctgta aatcaatttg agggaactaa tacattaata 63780
atgagtcttt tgacatatta atgtgatata tagttcaatt agtcttttaa aatttctaac 63840
agtgtgttgt attggatgtt ttctgatgct gttatagatg gtattgtatt tgaattctaa 63900
tttccaggag ttcactgctg atatatagaa atacaattca tttattagta catgaatttt 63960
ttatccggta aacttgctaa gctcacttat gagttttcca gtaccttatt atagattcca 64020
caggattttc tttgttcgta attataccat ttagtaataa agacagattt gctttttctt 64080
ttctaatatt tatggctcct tttttttttc ttgtcatatt gcactggcta ggacctccag 64140
tactatgttg aatagaatca gtcagactgg gcaccattcc ttggtttcca aacttagagg 64200
aaaaacattc agtctctaat cactaattat gacattattt gttatttttc atagaagccc 64260
tttatcaaat tgaaggagct tcttcctagt catttttgga gagccttttt ttttttttta 64320
atcattaata ggtgttgaaa aatgctgttc agcatctgct gaggtattca tatttttcac 64380
ctatattttg ttaatatagt caaatacacc gactgatttt ctaatgttaa accaatttgc 64440
attcctggag taaatctcac ttggttatgg tacattatcc tttttatata gtattaaatt 64500
ttattttcta aaattttgtt aagaattttg catctggctg ggcacagtga ctcacgtctg 64560
taatcccagc actttgggcg gccgaggcag gcagatcatg aggtcaggag atcaagacca 64620
tcctggctaa cagtgaaacc ccatctctac taaaaataca aaaaattagc tgggcatggt 64680
ggcgggcgcc tgtagacgca gctactctgg aggctgagtc aggggaatgg cgtgaacccg 64740
gaggtggagc ttgcagtgag ccgaggtcat gctactgcac tccagcctgg gccacagtgc 64800
gagtgcaaaa aaaaaaaaaa aaaggaattt tgcatctgtg agagatatta gtctgtagtt 64860
ttatacttcc ttgtaattat gggagtaatg ctggcctctt gaaatgaatt gggaagtgtt 64920
tcccattcca caattttcta gaagagtttg tgtaaaggtg ttttcttctt aaatgtatga 64980
tagacttcac cagcaaaggc catctaggtt ttaaattttt gtggggagga gatttaaact 65040
tatgaattta ataactttga tagatgtatg attattttaa ttttctttta cttcttaagt 65100
cagttttagt aatttgtaac tttcaaggaa tatgtccatt tcatataagt tgccaaattt 65160
atttgtttaa tgttacttat agtaattatt taattatcct gttagtgatt tagttatcct 65220
attaataatc tcttcaaaga atcagatttt tgttttattg attttctcta ttgtttgtgt 65280
tactttctca ctgacttttg ttcttatctt tattgttccc tttccttact tattttcatt 65340
ttaattgact ttttttaaat agattcttaa tttggaagct tagaactctg gtttttagaa 65400
ccttcttatt ttgtaacaga aacatttatt taaggctata tatgtcctta taaatatcac 65460
tttcactgca tcccagtatt ttgatgtgtc atctttccat tcatttaaaa aaattttaat 65520
ttcctttgtg acttctttga ttcatgagtt atttagaagg ctgtcgttta ttttccaaat 65580
atttggagat ttttctggat aactttttgg ttattggttt caatttaatt ttgttgtggt 65640
cagacaacct actctgatga tttctatcct tttatattta ttgaaacatg ctttatggat 65700
tattatatga tctgtcttgg tggtgtgcca tgtgcaactg aaaagaaagt atattcatct 65760
gttattgggt caaatcaata ggccaaattg tttggtaaaa tttctcaagt tttctgtgac 65820
tttactgatt tttctttcta tttattgtat ttgaaagaga actattgaag ttgtaattga 65880
ggatttgttg gtcgtctttt cagttttatc tgtttatgct ttgtatattt tgaagctctg 65940
ctgtttgttg tgcaaacgtt aaggattata tataaaaaat aattttttaa gtgaaataac 66000
cactttatgt taatctaagt ttgcagttag tatcattttc ttcttctgga agaattccct 66060
tttacatttc tagtgcagat cttccagaaa cccatgtgca gattactgga gctatttttc 66120
tgtaactgcc ccagaactcc cagctattgt agtctccata aatgttgatg tctatctcct 66180
catctcagga aagccgtgag actgtttaaa tttcttctta tgtgtatgcc ccttaatttg 66240
tctccaagca gaagaccaga gtgatcatag ggctcacata atttgttacc cttctttcag 66300
gtattacata gtcctgtgct gtctgtcgcc cagtgtctat atccagtcat ttaatgtatt 66360
tgtccagttt tcttgttgtt tatgtaagta ggttaagttc attcacattt gttgctctat 66420
catgcctgaa agaactctct tcaagtattt ttaaagaaaa cattagaaat tttaacataa 66480
aataattata aaatgcacta tgctgcttgt acaaataatg tgctaataga catttcacaa 66540
acatataaag tgggataatt atgataattt aataatcttt ataattatgt aattgttact 66600
aaattataaa ttctatttta ttaaaattct taagcattaa aataatttaa attatagaat 66660
taattgaact tcagtaatga accaggtagg aactgtttat atcaggattt atactgaata 66720
ttataaaggg gatatttgga tatacagatt ttataatttg gttttgaagt aaaatgaatt 66780
ctttgttttt ctaagataaa gagtagggga atttaaaatc ataattttca caaatgcatt 66840
cacattattt atctttaata tgatttattt attgatcttt tttgtaaatt tattattttg 66900
aaagtactgc cttttcctta ttttataaaa taattattgc cagccaaatt tattgtgttt 66960
attttaatac cattccataa aagaaaccat gaaacatgaa attcagatag gaatatattc 67020
aaaattgctg ttaaataatt tgtgtgatta caacatttaa agcaagattt gaaaaattta 67080
taagaaaaat tcagggagtt aatccactct ctttcctttg ctgctagatc ctattccagt 67140
ggtctctata aaaaaaattc agagaaacag aaagcagtaa cattgatcag attgcataca 67200
aactttctgc acacacacgt atttgttata gcttatgtaa ccattgattg attttgcttt 67260
tttctgctgg actatgagct cctctgaggg atagatttat ttttttcctg catatcatta 67320
tccagtgctt acccagtgtc tagtctgtaa cagccattcc ataaatattt atggatgaag 67380
aaaaatgttg ttgaattttt aaagtgaaaa accaacatgg cttatcattt ctattttaaa 67440
gattttacaa aggaaatgga ctgtgaaatt tccattaata aaaataggtt taatcttcca 67500
tgactgaaca aggaccttat gattgagtaa gcttttcata ctcactttca tgttacttta 67560
tcattttcaa aataggaagt gaaggctcat ttcttgtgaa aaagaaatca aattcaatta 67620
gtgtaggaga attttaccga gatgccgtat tacaacgttg ctcaccaaat ttgcaaaggc 67680
attccagttc cttggtaagt tgaattgtga ttatgttgtg ttttgctact gacattctct 67740
tgataactaa aatttatgcc aaagctagga acaattggta gggatttccc tgatgtatga 67800
aaactataat tttgagatgt tttctatatg tatatatatg aaaacacagt agatgtaaat 67860
tatgctaaat tcacatttgt agtcttttga gtatgcaggg tatgaatttg tttggggcat 67920
atatatgtat acttgcagta cacttcaaga tggttttctt cttctttctt ttcagaactt 67980
catgtctgaa aagagcccag gctagacctg tacctaatgg tcccatgaac actttagcta 68040
gaaaccttac agtgatttct aagaaaccag acagaagtct gaaggacact gaacaagatg 68100
gagtagcata atataattca ttgcttatct ttgtctatgt ctatatctat atctataagt 68160
gtattgaaag ttatttaatt ttttagacac cattattatt atttcaacct cctatctgtt 68220
ttggaactat agaaggacta ttgcatattt gcatgaggag tttgatcatt ctagttgagg 68280
aaattgggag ccaccttatt ctcaggttca ctttgaagga tctattctaa cctatgctct 68340
aattttgatt atagctgaat actaaaaata tcagtgtttt tatatgttaa ttctagacct 68400
taagatgggt gaaatgaatg actatagttg aatcggttaa attagctctc agctttatat 68460
atgctctttc gaatttatat ataaatttag ttataaaaag tagtttggtt aatgagagaa 68520
attatataga tatagctttt tgactcaacc tttctgtttt tcagtttcct tatatttaaa 68580
acaaaagaga aagagtagat actaaggtca tttgagcaca aaactgaatt gttttctttt 68640
atcttcataa ttgggttctt agtttttact tgcctatttt ttcccataat tataaatacc 68700
atttaaccct attaaaattt catggttctt tccttataaa aatgtcctct tgtccaacaa 68760
gtgacagcaa ttttattata aatatcattt tttttaatag gggcccattt ttgatcatga 68820
agatttactg agaagaaaaa gaaaaatatt atcttcagat gattcactca gtaagtattt 68880
ggatgtaatc ataagtaaat agatactttg ggcagaatac agtgtttggt tgaatttcct 68940
ccaattattc aaatattctt ggggccagtt tcatcttaca taatttccca taagctatag 69000
aaaaatgaag tatacattta aaatttacct ttcttgaata ttatagaaca cgttagtctt 69060
tatttttaca agttttctga agtgtaaata acacctccca ccagtgccac tcttcatcct 69120
ctcttccagt tttctttttc tttttcccac accatttata ccacctgatt aaacgctttt 69180
tatctactgt tcatctctgc cactggaatg taaactccat agtttggttt tctactgaat 69240
cttcagtgcc ctgaagaaag cctgattgct aggaggtgct cagtaaactt tcactacatg 69300
aatttaaatt atttgcttat atttccattg tctgtctgtt tttgacaaaa gggtcatcaa 69360
aacttcaatc ccatatgagg cattcagaca gcatttcttc tctggcttct gagagagaat 69420
atattacatc actagacctt tcagcaaatg aactaagaga tattgatgcc ctaagccaga 69480
aatcctgtat aagtggtcat ttggagcatc ttgaaaagct ggagcttcac cagaatgcac 69540
tcacgagctt tccacaacag ctatgtgaag taaatttaat ttatccttgt aacttttaag 69600
acgtttgaag agcttttgta tttatatcta gtttgcctga ttaagtcttt taaaagaaca 69660
ttctgctttt gtgtcactgg gcaataagtc ccccgttctt ctggtttttg cacacatatc 69720
ttagtctgtg tgatgttcag gagcatcttt gagggcaggc cgtggaaaca gatctgatta 69780
aaaagaaatt ctaggttttg tacagagtac atgttaaagt ctatcaagtg tatattgatt 69840
aaactttaat catttaattc aagtaagaca acgtcaacta tttaaattag attaggtaaa 69900
ctagaattag acctggtttg gtagtactgg ctctgactca gctacaactg tgtgacaata 69960
cgaacatgtc actcctcctg ctctaatctt tcattttctc atctgtaaaa tagagattca 70020
actaaatgat tattgtggct tatttttttt ttccagttta aaataatgtg taacttaaaa 70080
gattttcatt tttggtcaaa gttcctgtct tataagaatt aaactataat atagtttgtt 70140
gataggatag ctctctgaaa attgactttg ctcaacattt gtatgtacta cagatcaaaa 70200
tagttttgaa agccaaagaa gatatgaaaa ttaaaattat tttaatgcaa atgtttaaat 70260
tgttaaatta aattctcaag gctgggcgtg gtgactcatg cctataatcc cagcactttg 70320
gaggctgagg caggcggatt tgtctgagtt caagagttca agaccagcgt aaacaacagc 70380
aaaatcttgt ctctaccaaa aatacaaaaa attagccatg tgtggtgggg tgcacctgtg 70440
gtcccagcta ctgggtgctg aggtaggaga attgcctgat cctgggaggc agaggttgca 70500
gtgagccaag attgcaccac tgtactccag cctgggcaac acagtgagac cctatctcaa 70560
aaaaaaaaaa aaaagtcttg ttgcaaatgc atttccccct ttttaagtct aaaaaattat 70620
cataattttg agatgtttta aaggcaatat tacataaatt ttaagtatat ttaaggggtg 70680
tttttctctg taaagttttt atatctggag acagagagaa gaaagaaagg tgacccactc 70740
ctccagccat gctgtaatgt ctaaaatgtg tctttctctc ttcacctctt tgccttgcta 70800
aatacttcaa gtcacccagg gctcaattta aatgtcactt catcactctc tgcttctctt 70860
cctttttcct tctaccctcc agccaacctg gccacctaac ctccatttcc ataacacatg 70920
atgctttccc tctaattctc attcagtcat ccaatttgat ttaaagtacc tttgccttca 70980
ctaaactgtg aactccttga ggacaggact tgtttcaggc ttgtttctgt ctattcccag 71040
tgcctagtga gacctgacat atggtagaag tttagtagat acttactgaa ttgatttgtg 71100
gaggcattaa tgcctgaaac ttggtaatac ttcaattaat atttgttaaa tgagcaagtg 71160
aaataattca gagatttagt ctagttaaaa caaagagaat tggaaggctg ggcacggtgg 71220
cgcaagcctg taatcccagc actttgggag gccgagacgg gcggatcaca aggtcaggag 71280
atcgagacca tcctggctaa cacggtgaaa ccccgtctct actaaaaaat acaaaaaact 71340
agccgggcga ggtggtgggc gcctgtagac ccagcaactc gggaggctga ggcaggagaa 71400
tggcgtgaac ccgggaggca gagcttgcaa tgagctgaga tcacgccact gcactccagc 71460
ctgggcgaca gagcgagact ccgtctaaaa aaaaaaaaaa aaaaaaaaaa aagagaattg 71520
gaagagatgg tgataaggtg agacatgctg gcattcaatg actggacaag ctcagaacct 71580
tctcttaggg aaatttcaaa atgacaccat tagatggtac tttgtttgtt tgtttgttat 71640
tgtcaaagag tctcaactat gttccttttt ataagaaaat tttctgatta aaccctggga 71700
ataattttaa aatctttact ttggaataag ttaataaggg tctgaaacaa aggcaggaat 71760
tttgaaacaa cttctgaggc aaagagtcat taataagcct ctataatcat atcaaagtct 71820
agaatttctt gtgtggataa atatactgat atataaagaa gaacatagag aagtgattgt 71880
ttttggcatt tgagctcttt aagagtatta catacaaagt tgtaaaaagt cgacataata 71940
tgtaagtagg ggtttgctgt tatcattgta aaattataaa ctgcttaaaa atggaaagta 72000
gaaatttgaa acaaaaagtt tcataaaaaa gaggaggttc taaaatgaaa cacatattgt 72060
atgtaactat ttttatggtt aaatcttata tatatcaaaa tatgtaacaa tttctgacag 72120
catttaaaac atattcccag gattatgttg tgctttttct taaatcatta attcaaatat 72180
ttgctgaggc ctattctgct tccattttgc tctttctgga aataatttac aaaaaagctg 72240
aaggaagctt tcaactctat tttcatgaac ctgcttttta cagtctaccg ttgtaatttt 72300
gctggtttta cccatgctat aagcagaggt gattgggcta atcagtatac tgaaattctg 72360
ttgtggattg tgttttcaac tttttgaaaa ttcttgatgg ttctagttat cagaggtgtg 72420
taaggcagaa atattagcta gacttaagtt cctcagatgg tccactttag aattttaaac 72480
tcttgtcttt tcagactctg aagagtttga cacatttgga cttgcacagt aataaattta 72540
catcatttcc ttcttacttg ttgaaaatga gttgtgttgc taaccttgat gtctctcgaa 72600
atgacattgg accctcagtg gttttagatc ctgcagtgaa atgtccaact ctgaaacagt 72660
ttaacctgtc atataaccag ctgtcttctg ttcctgagaa ccttgctgat gtgatagaga 72720
aactggagca gctcatttta gaagggtaag aaagagctca ttaaaaataa aaggactgcc 72780
taaatatgct gatgttaaca aaatacgctg acatttgtat agtcatgagt tttgacaaca 72840
tggtgaaact ccatctctac taaaaataca aaaattatcc ggggttgttg gtgcgcgcct 72900
gtaatcccac ctactcagag gctgaggcat gagaatcgct tgaacccaag aggcggaggt 72960
cgcagtgagc caagatcgcg ccattgcact ccagcctggg tgacagaggc gagactctgt 73020
ctcaaaaaat atatatatat atatatataa tatatttatt ataatgtata agtattatta 73080
tatataataa aaaactgaga caatgaatat tacaactttt atcaatgact tacattttca 73140
caactaattt ttaaattaat gagtcctctt cgatgctatt cttcgaaaac aaattgtttt 73200
tggtattttt tctttaaagc atatgaattt atgcagttta atcattatct tgtctcttgt 73260
gactagaaat aaaatatcag ggatatgctc ccccttgaga ctgaaggaac tgaagatttt 73320
aaaccttagt aaaaaccaca tttcatccct atcagagaac tttcttgagg cttgtcctaa 73380
agtggagagt ttcagtgcca gaatgaattt tcttggtaag tgttctgtgt gggtctcctc 73440
cttaccaggc cctctaagtt gtacaagatg agtcacatat ggacccttta ggtggggatt 73500
gaaaggtggc atttcagttt aaatattatg ctggatttaa aaaataaagt cagcaggttg 73560
gcaataaaag aaaatgctat caaactatga aaataaatga aagaaatgta aatgcatatt 73620
gctaagtgaa agaagccaat ctgaaaaggc tacatactat tcgttccaaa ctataagaca 73680
ttctggaaga gacacaatta tgaggacatt aaaaagatca atggttgtca ggggttaggg 73740
gagggagaga tgaataggta aagcacagag gatttttagg gcggtgaaac tgttttgtat 73800
actacagtgg gggatacgtg ccattgtaca cttgtcaaaa cccatagaat gtacagtaca 73860
aagaatgaac cctgatgtaa actatggact ttgagtgata atgaagtgtc aaatattggc 73920
tcatcgattg gaacaactgt gccaaactaa tgcaaattgt taataacagg ggaaaatata 73980
tgtggggtag tggtggtgag agaagggata tattgaaagt ctttggactg tctgctcaat 74040
ttttctgtgt atctaaagct gctctaaaaa tagtctataa tttaaacaaa gttatcacat 74100
ttttattgtc agaggttaaa atgatagtta cttggcctac tgtgtagtgc actgtggttc 74160
cttttagtct tcaactaaac atgactgcct gagctgggta aggcatcctt atactgaaat 74220
actgtttttc atactgaagt ttcttcagca attttttgta tgataaatat gattactctt 74280
attgctgttg ttagaaacaa aattaatcat ttaatagttt tcaatttagt gaagttaatg 74340
tatattcaat cagcccttgt gctttgtaag acattacaat aatgcaaatt attatcatca 74400
cttttattaa aagttgtaga atcccctgca ttctcttagc ttatgaaata atagaggaaa 74460
ttatgttcat ttgtatccta aatgaacatt ttaatattaa ggaacaaaat acttttatga 74520
taataaacag gaattcccca tattttatct tccttcatag agaatactca cttcttgcca 74580
cccatgtgat tattctatac ctgactcagt aaaataattt ttaattctat ttaatagcag 74640
aatatggctt gactgcttat taatggtatt ttaatttgtc agagctttca gaaactaata 74700
atgatcaaag ccatcttaat ttggatagta ttttcctcat ttatccctcc ctcccttcct 74760
cctactctca tgaatattgg ccacattcta actatgatcc tgaaactgga gatagagtga 74820
ttcactcact cactagtaag caaagcaaac ttggtctctg tccttaagga acttgtgatt 74880
aagttcagag gacagacaaa cattaagtaa tgatggcaca aataaatgta attttatatt 74940
gtggtacctt ctgtggaaaa gtttcaggat gctctgtggt acctcagggg aatctgattc 75000
agactgtgga gtcagggaag cctttctgtt cctgtgacat ttaagttggg tctggaaaga 75060
ggagcatcca aaatgaccct gaagcttgtg tatggtcagt gtgtcatctc agctgaatct 75120
cacaatgatc ctaatggtcg tcgtacctag gacaggtatg acctctgccc agttgaggaa 75180
attgaagcag cgagattttt ttgtgtgatg tttacaggtg catgtaatta attatcttgt 75240
gaaagtttga atgggcccca gttcaaaatc tgtttgcttt gcactacaca agcttaatag 75300
tttgaaaagt ggtcttacat ttgagaagat gccccacgga ggtgacatct gagcaagacc 75360
actaaccatt aaaaaataat cccatgtaaa tggtgaaacc tcgtctctac taaaaacaca 75420
aaaattttta gtttttttta gtaagcgtgg tggcatgtga ctctaatccc agctactaga 75480
gaggctgagg caggagaatc gcttgaacca gggagtcgga agttgcagtg agtggagatc 75540
atgccactgc actccagcct ggtgacagag caagactctg taaaaaataa ataaataaat 75600
aaataaataa ataaatccca tgtaaaatat agttttagtt ttgtggcctt atgaatgttt 75660
tccatacaac atatgaaact caagactctg aagtcttaag tggagaatca tttctactca 75720
tttattttgc caataggtga ggtataatat gtatcattct gcttctcagg aagacagctt 75780
ctgggagtgt cctggaacat tttgaccctt gaagattgtc tagataaatc ataacccgta 75840
ttttttaacc ttgaaaatgc taataactaa ttcctcaagc cattttcaca gaaccgtaga 75900
tttgtagata tttcacgtat ctcagcgttc atctgatcta gctgcactct tttacagata 75960
agaaaacagg ctgtgtgatt ttctgtttcc caaattgtgt ttcacagaat tttattcctt 76020
ggaggtacct catactgcat ttccttctta agaattcaca aaataggccg ggcgcagtgg 76080
ctcacgcctg taatcctagc actttgggag gccgaggcgg gcggttcacg aggtcagaag 76140
atcgagacca tcctgnnnnn nnnnnnnnnn nnnnncgcac ctgtaatccc agctactcag 76200
gatgctgagg caggagaatc tcttgaacct gggaggcaga gattgcatta agctgagatt 76260
gtgccactgc actccagcct gggcaacaga gagagactct gtctcaaata ataataataa 76320
taataataat aataataatg taaaaaataa aaaagtaaaa aataaaaaaa atcataaaat 76380
acaccagagt tttgagaact cagatatttt actttatttt accgaatgtt tcccaatctc 76440
ttaagattat atggtcaaag aatactttca ttaaataaca cccattatta ttccatagaa 76500
cactctttat gagctagtac tataaataat ttttgtcctt ataatatgct gtatattagt 76560
aaagtgttca aagttgtttt gctatagtta tttaagagta attttagtta atctatatga 76620
tatataataa catcacacat aatttgaaat gaatattcta ataattttta ctttgtacaa 76680
atgttgggta gttaaattta tatttaaata gctgtttagc ttccaggtta aaagattctg 76740
gtaagtatgg cattttgttt tattgtttag tggaagtatt aaggctatta ctttattttt 76800
aaaagtggat ttttaaaaat tgtcagtgtg agaatggaaa ttaaattaaa ttaaacacca 76860
ttggtagctg ttcttatttt tgaatttaat ggaaatctgg ttaaaatgat taaaatgttt 76920
atctcatttt ttttctttta gctgctatgc ctttcttgcc tccttccatg acaagcctaa 76980
aattatctca aaacaaattt acatgtattc cagaagcaat tttaaatctt ccacagtaag 77040
tttattgttt ttttaatttt aaaagcacat cagctggaac agaaccttta gaaacatgat 77100
ttcgattcag tcatatggag gtaattgctt tctaaaccta cttagcttaa tgtttttgtg 77160
tgtatgaatg attttcactt gataaaagac ccaactcatt acttaaaatg gaaactttta 77220
tattaattta gtggatcatt gtgtaaaaac aacttaggat tgtttaatta attgctgtat 77280
tagtataatg aaatgagagt atactggcta tcactttaac ttttaaaatg ttagtggaac 77340
ttgatatgtt gccagaatac ccttaacttt gacattatgc ttaagttgtg tttgagtgaa 77400
attttgggtg aagattaggc aagtttatgt agttccaggt ttttgaggta ttttggttaa 77460
tttcatgaaa ccagaagttt cctgttaact ttaaattgag gcattaattt gatcttgatt 77520
gtgttgtaat cttaaattct attctaatta tatcatacat gataaaccaa attcataaaa 77580
tatatgtgta aatctatctt ttcctttgtt ttcttgctgt cagctattcc ttcaaacact 77640
gtggcttttt agaattaaga ctaaaatgct acttgcatga tgctgcaatg aactcttctg 77700
tgagctcata tttagggaaa taataattat aatttagcca tagagagtgt tacacaaacc 77760
tataatagct aacttacatc tagctttaga atgtgtcgaa ctattctaac tactctacag 77820
cggttcgcct ctttaatctt cctaataatc ccctacaata gccactgtta ttatctccac 77880
ttcataagag atgaagtaac ttgcccagct catggttctt aaactctggt ggttcaactt 77940
caggctctca aatcacatgc atactcatat gtcaataatg ctagttttga cattacacct 78000
tattctcacc ctgaggaaaa ttatttgtga tgttatttca tgtattttgg aaatactcat 78060
atgatttaca tctttccatt gtattgtttt agcttgcggt ctttagatat gagcagcaat 78120
gatattcaat atctaccagg tcctgcacac tggaaatctt tgaacttaag ggaactctta 78180
tttagccata atcagatcag catcttggac ttgagtgaaa aagcgtattt atggtctaga 78240
gtagagaaac tgcatctttc tcacaataaa ctgaaagagg taagatgtca cttttaaaat 78300
tattgccact taaaaaatat actttatgat ttgcatcatc acaaattatc attttaagtg 78360
atatttagct tctaaatacc agtttcatga aactagaagc ttcctgttaa ctataaattc 78420
ctgtcaacta taaattcaga tttccattaa attcaaaaat aagaacaact actaatggtg 78480
tgtcacttaa tttaatttct attctcacac tgacaattta aaaaaatctg cttttgaaaa 78540
tatttaaaag tagtagctgt aatatttcca ctaaacaata aaacaatata caatacttat 78600
cagaaccttt caatctgaaa gctaaacagc tagatataaa tttgtctacc caacatttgt 78660
acaaagtaaa aattattaga atattcattt caaattacgt gtgatgttat catataacat 78720
attatagatt aactcaagtt actcttaact gttacttaac tatgacaaaa aaacttagaa 78780
tgctttacta atacacagtt ctgtatagta ctagctcata aagagtgttc tatggaatag 78840
tagttgatgt catttaataa ttataaattc aaaataagca ttgtaaatat caatactatt 78900
caattttttt ggtttttaaa taagttctaa gcctacccaa tggtaaatgg atatggtaac 78960
acagcgtaat ttccttaaaa aatacttttg tgctatattt tttaaggatt atatgaatta 79020
tacataatta tagattaatg ttatgctgtg tgtcattgta tcactaaatc tctgtccaat 79080
ctgttaacag actcttagat gctccatttt tctcaagttg ttgctggcct gtgtactata 79140
ttacttgttt ttcagctttc tttggtacat tcttaaattt ctgcattcct gcaccatgct 79200
acctatcacc ctaatggatc aatctttttg ttttgctcca ttctctctgt tataaatctg 79260
aaattgataa tctatttgtc tcagaaaata tatttttttc aagttctagc gtgttgccta 79320
caaaaccaaa agaagtaagt gtctgacact gaggttcaga aaaactgtgc atatattttg 79380
ctacctgatt ttttgccagc aaatgagtgt tttctattat aaatacagta tatattactt 79440
aaaaatttgg aacagaagag aaatcactcc aattaggatg ccgcctaaaa tataagcatg 79500
ttgctttact ttgagaatac taaattgcgt gcaggtttgt agtgactcta ggtcttcttt 79560
gctttactga aggagcagaa tgaagccaca gataatggat ttggataacc aaatccattt 79620
tgtggtaaga acttccttac tttcaatgtc ttgaagagat gaagtatgtt accaaaggag 79680
atggggtttt ttaagattac agatgagtga catagattgt ttgggagtaa gtttttatat 79740
gtaagttttc atgtttttaa acacatactg acaacttatg acaaaccttt ggaaagtttt 79800
agaactctgt tgaaagattg tgcaagctgc tgatggaatc tgtgagcctt tcttgtttct 79860
tatcatcttg ttttttggca gaatacattt cttccttccc accaacagct tttgcccatt 79920
tttttccatt aagattcctc ctgagattgg ctgtcttgaa aatctgacat ctctggatgt 79980
cagttacaac ttggaactaa gatcctttcc caatgaaatg gggaaattaa gcaaaatatg 80040
ggatcttcct ttggatgaac tgcgtcttaa ctttgatttt aaacatatag gatgtaaagc 80100
caaagacatc ataaggttag attttttttt tctatttgtt tttattaaat ttatttcaga 80160
ttttctactt tctgtgactt tgatggacgt acattgttac aatttaggga aaaatgaata 80220
gtaatatttg gcattaatat gctgtgtcat ttgcctttca tttaatgaat gcgtttctgt 80280
ggtgccactg tagagatttt tcattcttct tagccaggct aatgttgaga gcagcttctc 80340
ctccttctgt ttcttttcac tggagtagac tctaaaagaa aataagtatt gtgatttggt 80400
ctcttgatta cacaatctaa agaaatatag cacagtttaa taacttctca cactgaattt 80460
catatagcaa ctaggtaaca tatgcctctt acatcttaaa gtattatcat tactgacatc 80520
atatgaaatt actaacttct attttgccca ttaggatgag taatctactc accttgatca 80580
gttttgaaag caccaaaact tctcaagtat cactgtttct ggtctttaca ctctaagcac 80640
tttaagtgtc tttgataatg gattttatcc ccctttttat tccctttcag cacattggtc 80700
ttattacttt ctcataaaat cctttgctcc cttttccaca gttactgtat gaacattgca 80760
gacctcattt ctgtcatcac ctctcaactt gaccgtaata tcccccaagg cagagactat 80820
agctgtgttc agtcactatt caaatcttgg cacccaacac agtgcctggc atacaattag 80880
taattgttta attaccagtg atttatactt actcattctc ttctgcctaa aatctcttaa 80940
atttgtattt aacttcatct ctttttatga ggaaggattt tgttttctga actcctcctg 81000
agcttgattt cattttaaag gaaagaattt gttaactttt gtgctaattg tgactaccct 81060
tcatcctaca caattatttt tctctcttga aactggaaaa gatggttata taaaaattgg 81120
ttcaattctt actaaacatt tagtagaact agctttcagt gtattatact gtattatcaa 81180
aatatatatc taaatatttt taaacatgtt taacattttc agagaagaca gaaagacctg 81240
gagcaagtta gaaattgtaa gcatcatttg ctttttgaag aaagccattt ttcgaatagt 81300
ggtgcattct taagaaataa ataaatcaag aaaagtaatc ttttttggtc atatcatcag 81360
gaatgttggt gagattctta ttagtaatag gaatgaattg gtcactactc cgatgtagtg 81420
acttatgatt tagtcttttt ctctaatttg agactgtggc aacattttaa catatttcaa 81480
aatgtatctt tatctatcca ttatattttt gataacactt taaatctatt agtttaaagg 81540
tagtttttaa gctacctaaa cacttctatt tagttcagtt tttgcattaa gatcattagg 81600
gatgaaagct tgttaacagt tgctgatagt ataatagttt atatttattt atttatgaag 81660
taaggtgatc tcactataca tatatactat tatatgcata tgtgatatat atgaatacat 81720
atctatacat catatatacc atatatgtgt atatatacac acatatataa tgtaactaat 81780
atgaccttgt tatcaagctt tattataaca gtatacatat atgtatacct tgtttctatg 81840
tcatatggac tttgtgaaat tttatacttt ataatttata gggtttttct tttcttcttt 81900
acttttcttt ttgagattga gtttcactgt tattgcccag gctggaatgc aatggactga 81960
tctcggctca ctgcaacctc cgcctcttgg cttcaagcga ttctcctgcc tcagtatccc 82020
aagttgctgg aattataggc gcctgtcacc atgccctgct aattttgtgt atttttaata 82080
gagatggggt ttcactatat tggccaggct ggtcttgagc tactgacctc gtgatccacc 82140
cgcctcagcc tcccaaagtg ctgggatgac agacatgagc taccacacct ggcctgtaat 82200
ttacagggct tttcatacta tttaaagaaa ttcaaatatg tatacatgta tgtatgtata 82260
tgtgtgtata tttagatgta tatatattgc atatcgtatt ctaattagta ttgcaaatgt 82320
attttggcct tttgattatt tctggcgata gtgtaacatt ttttctttgg tgattttacc 82380
aaatattatc aaccacacta aaatctctag caaaatatat gcattaacag tactctgaaa 82440
gacatgtaca ttattagtta tatgagctat acagtctttt ggatattata ttttagacta 82500
gtgtgacatg caaaagaact cacctaaatc ttaagtgtac ttttcaacag tttattattt 82560
tatttttata tttcaaatac taggtttctt cagcagcggt taaaaaaggc tgtgccctat 82620
aaccgaatga aacttatggt tgttggaaat actgggagtg gtaaaaccac cttgttgcag 82680
caattaatga aaaccaagaa atcagatctt ggaatgcaaa gtgccacagt tggcatagat 82740
gtgaaagact ggcctatcca aataagaggc aaaagaaaga gagatcttgt tctgaatgtg 82800
tgggattttg caggtatttc tttctataga attttaaaat tcacttttac catttgtttt 82860
gaacagggat tcaaaaactg aactttctgt tctaatatcc agaaacctgg tatactgtat 82920
agaattattc caaagccctt tacttctcct aattttaccc ttgcctccag aatggaggag 82980
aacatggagg gatatgttgg taacaatacg gtgctaggta ttttgatcgg ttggtgccat 83040
atatgctaaa agtggtcaat cccttgtaaa aacccagaat agttctctaa acattatctg 83100
ttgtttttct cttattagta tgctaaataa aaaatagtat tattccccca gatatttttt 83160
taaaaagagt tcttgcctgt tgtttgaaag atttaaaaaa tttgtctcta atctttattt 83220
aggtcgtgag gaattctata gcactcatcc tcattttatg acgcagcgag cattgtacct 83280
tgctgtctat gaccttagca aaggacaggc tgaagttgat gccatgaagc cttggctctt 83340
caatataaag gtgatttatt ctgatctttt gaaaatagaa aattgtgtgt gtgtgtgtgt 83400
gtgtgtgtgt gtgtgtgtgt gtacacgtta atttattttg ggcaaacagt tgcttcagtc 83460
tctttaaata cttccttaaa agaagcacta aagttttgag ttgggaaact ttcagagtaa 83520
ttaaatcata acatgaaaat ggtatgttcc atattggtga atgttattga taacccgaaa 83580
ttcttttatg ctgtgaaact tgaaaatata tatgttcaac tgttttttta atcatattat 83640
ttcttaaatg aaatctaaat ttttctaatt taaaataagc tatattaaag aaaagcaatc 83700
tatatatatc atcaacttcg tactcagggg ccatttagtg tgaaatcctt cagattgtat 83760
cctttaagtg gtcccagatt attatgctgt tatgtctgga atctcccttt tgttgctttt 83820
gtatcttttc ctttgttgtc ttgttgtcag ctatgccttc aaacactgtg gcttttaaga 83880
attgagacta aaatgctgct tgcatgatgc tgcaatgagc tcttctgtga gcaaagtcct 83940
taaaaaggct tgtgtcagga tatttaacca tgtcatttgg ctgcatacat gcttgttttg 84000
taatttgggt gttttttaat gtttctttta ttaacttttt tacagctagc caacatgagc 84060
aaatattaca gtggcagtca tacttgcttg aatggctttt attctttcat tgtagactcc 84120
aaattgaatg actttaaaat gaatttagaa gattaaattc actgataagg aagagaaaat 84180
atacatgata tgacgttaat ttgatataat ttgtgggttt atgaaatgct tgttttattt 84240
aggagtggat aactcatctt aaggcatgaa gatgagaaag gaaaactatg ctactaccat 84300
tatataggct acctaaaagg gataaaaatt ggattaagga aagcctaaaa atgatttttt 84360
aaaatgtcga ggttacgttg ttttcttagg tttaaggaaa aaaggacagt tgttcttctc 84420
ttcttctgaa gtctgttagt ttctcttttc cactcaagtg aatgtcacgg aaagcaaata 84480
tcaacaggaa tgtgagcagg cccaatttga aagcaaacac aagagggttt tgtgtctttc 84540
cctccaggct cgcgcttctt cttcccctgt gattctcgtt ggcacacatt tggatgtttc 84600
tgatgagagg cagcgcaaag cctgcatagg taaaatcacc aaggaactcc tgaataagcg 84660
agggttccct gctatacgag attaccactt tgtgaatgcc accgaggaat ctgatgcttt 84720
ggcaaaactt cggaaaacca tcataaacga gagccttaat ttcaaggtaa catggtaggc 84780
tggtagagaa acgtaattta ttaattctca tgttatacaa ctgcctagaa atgtcagaaa 84840
ttttgagaag tgagcaactc acttaaaatt gtggggtttc tttccccatt gctgttagca 84900
ttgttaaagt cttttccatt ttaaaattat ttataccaga cttcatttct aattcataga 84960
aatgggaata aaaaaataat tagaggaccc tgagagaaac taagagaaca tttctgggat 85020
actgagaaaa tgtttctgag agagaatctg agaaaatgtt tttgatgtct tttctcatcc 85080
aacttcttgt agtggtggtt cagtccaagg gtaaaggtga atactgaggt cttgggatca 85140
tctttcttct attattcttt gactgttatt tttccatttg ctcctttcat ttggaattcc 85200
tattttatgg acatcttgat cctttgtgcc actccttcat gtattttgtc acggtgattc 85260
ccattccaat tttttttccc ctctgtattg tgaggcagct gttttattta gtcatgaaga 85320
ccactgactt ggttttcggt agtatctcac taattactta gttcatacaa aatggacttt 85380
ttattttagg aattatgttt taaatgttta aaattctctt ctggtaagcc aaatctttat 85440
aaagcataaa taaatcagtt atcagagaca accctctttt tttaatactt gcaggaaaaa 85500
gaaatattca ctgggatcta caggagtgtg gtgtaaactg tactgaaaaa tacccttgat 85560
agttccatat gacaaatata atgatgaatt tcacttagtc cctcttggct tagctcatta 85620
gcattaatga tcaagatcct ggctgataaa tagagtccta tttcgcctgg gcagtaccag 85680
cgtaattatt aatagtgtcc cactatattc tcaaaagcat tccaatttgg atgataaatt 85740
atatagtcac cttggttata actccgcgtt ggccagttag cttacataat ccatttatat 85800
agattatgtg tgcttctctg caaaacctaa tgagccattt gtaaaagtga tggattttgc 85860
ggtgtccggg gagagaattt gtatgtttgt gtccttcagc acacatttat tatagttatt 85920
aaaaggtttt attgatgata gacagtaatg tcatgtaaaa atgacattat ttatttgtag 85980
attttcctat tctcttgttg gacatgtaat tagaaagtaa tatgacttaa agaaaaacaa 86040
atacacaaaa tttattcatc cagttaatct cttaatcgag gttttttttt ttctgagact 86100
atacccatac ttcaaaaact ttgttgttac tgagaatatt ttgataattt cccttttcgt 86160
cattgctgtc agataatgta tcatatcttt aaaaagactt gttggaggac gagtttgttt 86220
tgaaaaggcc tgaatttagt tgatgcaaag tcacagataa gatggctcat taagctgtat 86280
taatactgct tttgtctaat agatatcatt accaataaat cagaccagat ttccttttgg 86340
cacttgtaaa tcaactttga agacaacttt ttacaaggaa gtaaaacaaa tgctttgaga 86400
aataccagta ttagtgaaag aaaagtatat attgctaatg gatgcagcat tctggcataa 86460
tggtttgaaa actcatttga ttgctttgta gaagagtgac tctttcggag gacccagggc 86520
ctgtgggcct gccagaactt gaaaattctt tcttccctga ggtgcttcaa cctgaattca 86580
aagagcagct tttaatctat tagagatctt tttttgtcct ctcatttatt tttcatcttt 86640
ccctttgatc ttagctcttc tctaatcttt ttctgtctca accttattaa catgtgtctg 86700
tgcagacact ttaagtttta tttttttgac tcagcctgtc agtgaactga ttatcatgct 86760
gaaaggagaa gcaggacaat acagagttga atgccgacaa tactcctttt aatcttgttc 86820
agcccattag cagagcaggc atccctttag gctttgagac ctagtcccct aaaactcatc 86880
ccgtttctac ttgatttgct ttctttgaga actcttgttt acttttatat ggaggtttcc 86940
ctccttggat taaaacataa acctcaatct gaagttccat ttcatcttaa tttatgaaca 87000
actctgagag ggaacatgaa aagtggagat tagtgaaatt atctccaatt ctctgggtca 87060
aaagatacac gaaaacagtc tcttgagtaa ccatttacag gtaaatacag aagtaatggt 87120
tattgttgtc tccttaaggt tttagtcaca aatgaaaaag accaagttaa ttttttgtct 87180
ctgtgtgctg aatttctgtt tgtagtaagt gtaagaattt aagcagaaat gctgtttctt 87240
attttcaggt gaaaagaata tgtaatttcc ataggtccag aaatagggag agtttgccat 87300
ctggtggttc ttacaggcat tgcggatgtt attaagagtt gcttttctat ttaaaattat 87360
attttaaaaa atgtttggaa gatactttta ttatagaaac tatcctctta agcccattct 87420
ttaaaaaatc ttcttttatg catttctcat tttgtagaca gtgattagat tctaaaagca 87480
acagaacaat gatcatcctc tcctagcaga atcactggtg tttagatgat ttctcatttt 87540
cccaaattca aggttccatg aacaacatag cttgagtggg atcttatgtc tccagatttc 87600
actgttgata tatgcatccc atcaatataa cattttacaa ataacaagca caaaatttaa 87660
tgttttacct tgaatattta aaatataata tccaaaagct cttgtaattt gtactgatat 87720
cttatgctag cgtgtctgtt tcacattaag tttaatgtct taagatataa aaaatctttc 87780
ttatggttag tgatttatct tgatttttgc catggaattt ctgtgtagca agataaacat 87840
ttccatacca ttttatttga tatttcctaa tttgcctctg gatcaacagt tttcctattt 87900
taatttcatt gtacttattc cttacaatct aaatagcttt ttattatatt ttgattttat 87960
ttaaaaatgt acttctgaat aacatatctg tttctgtaaa aactgttagc actgaatttg 88020
ccaaccattt gacacataca cgaataaaat agatttttac ggcttgtcat ttgtaatttc 88080
atagatccga gatcagcctg ttgttggaca gctgattcca gactgctatg tagaacttga 88140
gaaaatcatt ttatcggagc gtaaaaatgt gccaattgaa tttcctgtaa ttgaccagaa 88200
acgattatta caactagtga gagaaaatca gttgcagtta gatgaaaatg agcttcctca 88260
cgcagttcac tttctaaatg aatcaggttt gtgtgtttct ttccttactt tcaaagctca 88320
gctgtaataa cttataaaag tgtttctgaa tcttgtatag aatttacatt caaagctgag 88380
agaatatcca tacagttctt taatagggca ctgatttttt tctttttgga ggatcatcat 88440
gtgtgtggat gataaatcat gtatcatgtt gtaagaaaac aaatttagaa atcacctagg 88500
agtaaagtag tggaaagatt ccctgagtgg gagttaaaat atttgggttc tagaacttac 88560
ttgtactatt caggagctgt ggaaccccaa gcacaaccat atccttccat aatgtcaaat 88620
gagtttagtg catgtgaaac ttatttttat attgcaaagg ggaattattg ttggaatggt 88680
ctaactggga cgctttgaga atcaatggct ccctgagatg atgcagctgc tgagtggaag 88740
atctagctct ctttcatcaa atattggtct caacgatgaa aattctcaaa ccaacttcag 88800
tgctaattgt gtacttgatc atattacttt gccagaaatg tgtgagttgt ttgatagtac 88860
tagagtaagt gactgggaag ctgcttttga tccctagatt ctgttgtgtg aaaaatagct 88920
tcctgtggtt tatgatctgt tccttttccc cattgttctt aaggtatgct gaaatatgcc 88980
gtgtttctta tctgtatttg aaaataaaac atgtctttgt agtgtttatt cagcaagcaa 89040
aacagaaaat tatgaatttc tatgtatgca tgaaatatgc tttgtaatgc atgtcagtgt 89100
ctcaaatatg tttatatatg attgttttat gtagtttaaa aatactccat tataatattg 89160
ggactttaga ccataggatg cacagcttct agtcccagct ctgccactcg gtatgctgaa 89220
atttctttac ctgtaaaatg aggaagttgg actagattct ttctaaagcc ccttgatatt 89280
tgttctacat tccatgtttc actgtttgat gaatttttac tacaggagtc cttcttcatt 89340
ttcaagaccc agcactgcag ttaagtgact tgtattttgt ggaacccaag tggctttgta 89400
aaatcatggc acaggttggt gtcttttatt tttgtggcac ggggttatgg tcaaagcata 89460
gaacagatgg cgcccagagc attgagcatt ttagagtttg ggtttagtta aggcagaaac 89520
ttttgtgaat ttagaagact gtggaacatt tcacatagaa gactacttga agaacttcat 89580
ggaagaagga aagatgtctt gagttcactt ccatgacttg gttttccagc cacatacaga 89640
tgtttgtaac actctgtccc atgctgcttt actagatcct gatgatgtca tcgatttggt 89700
tactgaatta gtcaattgaa cgaaggcttt gtggaaatcc ttggggtaaa cacatagaag 89760
aaaattgggt tgctgagcct gtgaaacctc tatctagata acatggaggg gagttttgac 89820
ttaagtgaaa tgatctgaac tttaaatgct tatgattttg aaaactttgg atggcgttgg 89880
ttatagctgt ttttttctta tatttcacat ggaaaatgtt tttctctccg aatgataatc 89940
cattaccagt gagtttaatt agttacaata aaccatctct gtagctttga cataaaagac 90000
catttgagca aagcatacta cctcagggct tttcaacccc agcatgatga cattttgggc 90060
cagataattc tttgttgcac attgtagcat gttggcagca tttttggcct ttatattcta 90120
gatgtaagta atatccttta gctgtgacaa gcaaaaatgt atccagacat tgctaaatat 90180
cgcttggaga atgtgaaaat gaccctagtt gagaaacatt aagcttctga tttgctgatg 90240
agtaaaattt atagttttgc atgtggctgc ccgagtccct aaaattatta tatattttta 90300
tattagagat atctcttcca attaaaccat aaaggtaatt aaattcactc agacagtctt 90360
gaataattgt tcctaatttc gatctgagga aaaaaaggaa ggtattgtga agagagaact 90420
tagtcgaggc taaatccagt accatggaac tcgagagcat attgaaacat tgcagtcagt 90480
gattatttgc agtatgctag ttattgctat tttgggaggt atttttacat tagactttca 90540
acctttctac acatattgtc atggatcgtg tgattttact caattattaa annnnnnnnn 90600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 90660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 90720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 90780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntttata ttggatctac ttggcaattt 90840
aaagaatgtt aattaggaaa tttaaaaaaa ttcagaacta taaagaggta ctcacgtagt 90900
tttggaaagt gtgtcattta tgggcacaaa taaaaaagat gtgtaggtag ctgcatcctg 90960
tacagcaaag gaagttttaa atatatccag caattttgtt gtcctagttg gcgcatggta 91020
gctatcagga ggtaactcaa ctccatatag tcaaggaaac gctatagttg ctccctaaag 91080
tgatgtgttt ccatgtcact atggaacact tgaaaccgca cacatatgaa cattagggtg 91140
ggcatatctt gtacagtaga ataaggaaga ggtttgcatc agaatccccc ttttaaaaaa 91200
atgcagattt tcactatgac tgcaataaaa ttcctaaaga ttttgtggag taattaagtt 91260
gaaaatccat gaaagttctt ctcattaaca tagttataaa tatgataacg taagtaaaaa 91320
ttaagttaat ttgagccact cagagttact ttgaaagaca gatttaaagt gtcaataaaa 91380
tgataattta aatttcttgt taacctaaaa aagaagtacc atcattttta tttatgccaa 91440
taaattgaaa tataatgtca ttttctcact aacgtttaaa ggaaatgaaa gctctaaata 91500
atcaagtgaa accaagagca acttgtctga cagctattag caaaaataaa taagagtatt 91560
caccttcatg aatcaaggca agggcacgaa taatttcatg gtgcagaagc tctaatgagc 91620
ccacccactc tatgtgcccc gagctgtaag gtcactaaac taattttaaa aaggtaccat 91680
taaggcaggt agaagcttac aagactcatt taactgtatg ataaaagaga tatgaaaggg 91740
acctattgaa ttaatcaggt ggaacattaa aaagcttata tggtaattta accttgataa 91800
aaatacatgg gagaaataca aaggaatttg gaaaattctc tttccttgaa taaggcatca 91860
gttagctatt caggttatta ggttgaagga atgttaggag ctcttttaaa ggtgataaag 91920
tcaagataat gttgcagatt ttattcttac gtaacaaacc ccctcaaaac ttggaggctt 91980
aaaatgtgaa caatttatca tttctcattg ttctgtggct tgactgggct cagctgcgtg 92040
gttctgctcc acatggtatt cgcaagggtc attcacttgg cttcattcag taaactgagc 92100
tggaaagtgc aagaaaggta cgtgcacgtt tttggagtat tggtgcttct ccatgtggcc 92160
tatcgtatgg ctaggttggg cttcctcgtg gcgtggtgat tacagagtaa ttggacatct 92220
ttcatggtgg ctggttacca agagaaatga agcagaattt ttctgtcctc ttaaaggcta 92280
ggccgaggac tggcaaaagt attaattctg ctacattcta gtaaccagag taaccacaaa 92340
cctacctcag aataaagggg aagggaaata gactccatat gaatagcacc tgtgtatagc 92400
gatagaaatg atgtgtccat ctttggaaac ttctgctgca agtagtggta gcatgctata 92460
gatccactag gaaaatcaag cacaaactct ttaaaaaata aatgtatctt agtaaaataa 92520
attagaataa ctagataata atggctaaca cacatgaggt taatatgtgc ttttcaaaga 92580
ttatctcatg taattctcac agcaacactt ccaaatggta ttttattaac ccctgtgata 92640
cagatgaaga aactgattga cagagaggtt gaataattta cccaatggta cacattcagg 92700
aagaggtaga gttagaattt caaaccaagt cgtttgactc cagggcctat gagttacgtt 92760
catagggcta atattcaaat gagagaaaag aagtaataaa taaacatata atatgttgag 92820
tgggtgctac gaagaaaata tgaagtgtag ttggagatga gttgtcaaaa aaaggtctta 92880
gcacttaaaa aacactgaaa gcaaacaatt ctctttacca cctgaattgt aacagcaatc 92940
tggaattgct ataaagtaca caacatggga gaagtcttaa acaacagttt ttattattta 93000
taggcccatt gcacgctgtc attaaatacc aatatgtaca atcaatcatg cattcattga 93060
tttaataaat actgtgcaaa caaaatagaa atacagagat gggtaagaca agtccttggg 93120
cctaaggact ttataacctg gtatttcacc caactacatg atagcataaa taatgtttgc 93180
ttctgtttaa gtattccttg aacattatag atctaccaaa gaaaattaaa tacaaacctc 93240
tttttaaagt gaatttgaaa agcaaaataa attggaatat atacataaat atgctaaaat 93300
ttgtcatatg tactttgtgg gctttgcatg tgttatttca ttctcagggc aatctaagac 93360
gattactttt actgtctcat tttacagaga agaaagctgt gcattaaaga aatcaaatac 93420
ctttcccagg gtcacacagc tagtagcaga gcctggattt gaatctgggt tctgattttt 93480
aactgccatg acaatgatca aagctcaaag tatgatctct gtgttagagt tatcagggtt 93540
gctcgctaaa aaagccgatt ctcaaacctc atcccagacc tactgaccca gacactgcaa 93600
gtagaatcca tcaaaatgca gtagttactc tgagaatcat gaaactctac tacaccgtct 93660
gtcttcctat tcatggaaac cctctcctag tatataaatg tgaagaatat ttctatttca 93720
aacctgtatt gataattctc tggaagatca ttttcctggg aacatattat tgatgagact 93780
gcaaaacaga agtaaggtat tggattgatt ttttcactga agctagggaa atattgatgt 93840
tcattggttc cagagaagtt caatgatttc caatctgaat taactccttt aacaaatttt 93900
tttttttttt tttttttttt tttttttttt tttgagagtg aatgtccctc tgggcttcta 93960
ggccacatag ttgcttagag aaattaggta ctttgttgca cttgaaaaca ttaaaatctt 94020
tctgactact ttcactgagc aaagagacct aaaatgcttt aaatttgcaa cctttcagaa 94080
aataaattct agtgattatt tatgactcaa tctttcagat tttgacagtg aaagtggaag 94140
gttgtccaaa acaccctaag ggaattattt cacgtagaga tgtggaaaaa tttctttcga 94200
agaaaaggag atttccaaag aactacatgt cacagtattt taagctccta gaaaaattcc 94260
agattgcttt gccaatagga gaagaatatt tgctggttcc aagcaggtaa aaaaaacctt 94320
aaaaaataat tactacatgg aaattcacta tctattcttt taattgtcaa agtaactgta 94380
gtctataata gatgtattaa ataaataaat aaatatattt tgcttccagt gtaaacttcc 94440
tgctgacata tttattttgg aatgaaacat tgcatctgac actttaaaga tatagtaaaa 94500
cttattttat atatatagtt actagttgac ttatcactgt ttaaattatt taagaaaggt 94560
aaatattaga gataagtgtg tgtgtgtgta tgtgtgggtg tgtgcatccc tgtttatgta 94620
cgtgtgtgtt cttagacaac actgagagag tttattaagc aagttctgag aagatagtga 94680
gttttcaaca gaattttaaa agcatttatg acatcatagt ggatgcctaa gttttagcct 94740
atactttggc tgtcctactg ctttataagc aagtgggaaa tgttataaag taatatgatg 94800
ttgaaatgtg caaattacat tgatggatgc agccaattgt aaaaataaat atacactttt 94860
tttctaggac atgtattttt caggatttat gtaagattac atttgtctat tcataactaa 94920
ttataataat ttatgtatta gtgcacaggg attaccaaaa atatttcatg catctatatc 94980
tgagcatgca tttgaattga ttaatgacct ctgaattttt ggggtaggaa aaacatgtga 95040
aacaatgtta caaaaagact acagttgctt ggagtggtta ccttcattga ttttaagcag 95100
taaaatcatt tgctcaacat ttttgggtat gctgtgaggc tgtataacca tagtgtcctt 95160
ttgcctttag tttgtctgac cacaggcctg tgatagagct tccccattgt gagaactctg 95220
aaattatcat ccgactatat gaaatgcctt attttccaat gggattttgg tcgaggttaa 95280
tcaatcgatt acttgagatt tcaccttaca tgctttcagg gagaggtgag tgtttaatga 95340
agacttaata tttagagaaa ttagggagat ggcatatgaa aagtaatatg ccattttctc 95400
agagtttact tgtttggaag gcagctgaag aattagaaaa taagctcata aaaccttgga 95460
gtaggcaatg taaagataca caagcacata taacctcatc caatttgtca ggaagaaaac 95520
tccttaggtg ctcactcagc tcttggccgt gattacattg tagggagtgt gattatctct 95580
tttctgttgc acagccacta agccatttac aaagaaaaga gcaaatccag tgtttataat 95640
gctaactctt tcttctaaaa taaatagaga cattttggta ctgcaaaggg aaaataccat 95700
tttggggatt aaaattagct ttacacaggt gttacaggtt tccaaaataa accttatctt 95760
gattggaatt aatcaacata taggtagtta cattgcatta aaaagttcag aaagttttgg 95820
gtttagcaca atcaatttct ttttgaaaat tatgaggatt gatttgtgat tctctttcgt 95880
catcggttga gcctatttaa actgcttaac agcatcaacc tgaaatggat cttaatctac 95940
aggggattta actggtttta ttataaagtt atggataaaa tatttaatag atatggatga 96000
ggactcatat cgttaacaac ccaatacttt ctttcaaaat gagtagatct gtattacaat 96060
cccttgtggt gtgtgcagta gattttttcc ctttaattta ggaagcagtt aataaacagc 96120
tccatttgga tccatttaaa tttcttttag aacgagcact tcgcccaaac agaatgtatt 96180
ggcgacaagg catctactta aattggtctc ctgaagctta ttgtctggta ggatctgaag 96240
tcttagacaa tcacccagag agtttcttaa aaattacagt tccttcttgt agaaaaggta 96300
aggaaatcaa tttaaatgct tcaattgtaa cactaaagaa atctaaactt aaaaacatat 96360
atgtatataa acaaaaaacc tttactttaa agctttgtga cagtatgagg tttagacaag 96420
acgttgagct ctgttttcaa tcatgtaggc tgtattcttt tgggccaagt tgtggaccac 96480
attgattctc tcatggagga atggtttcct gggttgctgg agattgatat ttgtggtgaa 96540
ggagaaactc tgttgaagaa atgggcatta tatagtttta atgatggtga agagcatcaa 96600
aaaatcttac ttgatgactt gatgaagaaa gcagaggaag gtgtgttttg aaacaactta 96660
caaatgcgtt taagtgatcc ttcaatactt acaaaatgac ttttattaaa tgtaaatatt 96720
cttattcata acggatgagt tgaaaaatag tatattcaat tatagggact gttcagaaaa 96780
ctggattata tttattatca ataaaatctt gtattctaga ttcagaaaat gtttttgagg 96840
gtttgaatgc tggctcattg aacaacatat cctcatctgt gaaacaggaa taccaaccac 96900
atctatctca tagaattgtt ataaagattc aaatggacaa tacatggatg taatttacta 96960
acaggtctgc catataataa cagcttcagc ttcatgaatg tggcaaaagc agagaataaa 97020
taactttcta gtcagatgtc tggtagtctg cagcagttca gaattctaca agtgaacgta 97080
ggaataaatt tttgaaattc caagtagata gatattaagt gaatctttaa aatgttctca 97140
aattttctag agaaatctag gattggttag aaagggaggg gttagaaatt atagaaaata 97200
ttccattatt ttttcatatc aaaaccacag atttatgtat ctccttaaat gttgttttta 97260
tttaaaaaat gttttattac ttttcaggag atctcttagt aaatccagat caaccaaggc 97320
tcaccattcc aatatctcag attgcccctg acttgatttt ggctgacctg cctagaaata 97380
ttatgttgaa taatgatgag ctggaatttg aacaagctcc agagtttctc ctaggtaatt 97440
ctttttgtta atttgagaat aaaaattagg atgtattttt ctccttataa tttagaaaat 97500
agatctcata attatattgt catagatttt tactgtcttc atatatttgt tataatgttt 97560
tttatttgga atgatatatt ttaaaggaat atcatgttac acatctggaa tttgctttgc 97620
atataatcat gtagactagg atcaagatga ggatgagatt atcatggaag cacaaatatt 97680
tatgaaatat atctttgtat ttgccttaat tgccagggat gtgggaggca aataagaagg 97740
ttttcaggtg agttaagtga agcagccata ttttatattt aaaatgacag aataggtaaa 97800
ggaagcacac ctcagtgtag tcatagcagg ggttttatga ctgagtgtga caatgctgaa 97860
ttctcataga aatattcata aaaagccttg aaattaagaa gtcagaagtg tcacatggtg 97920
atatactcaa attctttttt tttttttttt tttggtatgc tgaacaattt acatttgttg 97980
gttccatgaa ttcaatcagt tattttcaat agaggatgat ggaaatcatt gaattcatgt 98040
agcatgttta ggtgttcatt gagaaaaggt gaagtcatgg taaccatgtt ccaatattct 98100
cgtttgtatc ttgacttcct ggacctgtcc tatcattgta catggatttt taggcctaaa 98160
agatgttttt aaaaaatgct catacacttc agaagatgaa aaatgtatgc attataacta 98220
ctttgggaaa gaagcagtca acataagata tgtcactgta tgtcattcag tagattacat 98280
gtgtggcttc tcatgtctct cagaataaaa gctaatgtct ttacaaggcc tgtgatgcca 98340
tgatctatct gactcctcgg ttattgtttg tttgtttgtt tttaatatat tttatacaaa 98400
tttatttttt taattgacaa gtaaaaattg tatatattta tggtgtacaa catgatgttt 98460
tgatatatgt atatgttgtg gaatggagaa gtttagctat ttaacatata cattatctca 98520
aatacatatt tttgtggtga gaagttttaa aatctactct aatagcaatt tacaagtata 98580
cagtatgtta ttattaacag taggctgatg tactcaagtt ttaaacattc cagagagtca 98640
ttgaggcaac tacgaaatgc attagactga tttaatgtaa agcatttaaa gacaattttg 98700
accttacttt gtttagtttt tgttgttgtt tagtttaatt ttaatcaaat taccccagag 98760
ataatgccta aaatctatca gtcaggacat aatattctta gcaaaaaact gtccaaaatt 98820
tgggacatga tatttaaagc taaataaaca cctttatact tttcatactg gcattcattg 98880
ggaagtttag gatgaattta aatgctttgg aactgaggaa gttaatgtat tagtaataga 98940
ggattaacac aaaatgctga atcgtcaatg ctgaatccta cattttaatc aaccccaaac 99000
ttcaaggtat acaggaaagt accagacata gtgcatcctt cctctgaaga aatcccaaac 99060
tgtcagacac agattcctaa aatatttctt tgtcctgcat taaaatgtgt ttcagatgaa 99120
tggacacgtt ttgagtagtg tatgtggaaa cgtcatttac aaagtccgtt tagttggccg 99180
ggcttagtag cttactcctg taatcccagc actttgggag accaaggcag gtggatcatg 99240
aagtcaggag ttcaagacca acctgaccaa gatggtgaaa cctcgtctct actaaaaata 99300
caaaaaaaaa ttaggcgggt gtggtggcgg gtgcctgtac tctcagctgc ttgggaggct 99360
gaggcagata attgcttgaa cctgggaggt gaaggttgcg gtgagccgag attgtgccac 99420
tgcactccag cctaggcgac agagtgagac tccgtctcaa aaaacaaaaa caaaaacaaa 99480
acagaaacaa ataaacaaag tctgtttagt tacacagata agaaaatgtt tgtgattact 99540
ctcccttctc tagacctatg tcccataaat ccataaatcc catgttcact tacagaaagc 99600
agtctagata ggagtttctc agtctttgag ctgttgccat tttggctggg atgactgtta 99660
tcgaggtgca tcgtaggatg tttggcagca tctctggcct ctacccacta gatgtcagta 99720
gtatctcccc ttcttccctc aggtgtgaca atcaaaatgt ctccggatgt tgccaaagat 99780
aaggggcggg gttgagtatc cgtgatttaa caaattaggt gtatccttct aaaaacattt 99840
tacaggtaga gactccagca tctttatatt agggtaatct ggagaaggtc ttgcctctct 99900
ccgttttccc tcttcccatt tttattgtag ggcagcagtg cattcaggct ttttgaaaac 99960
tctctttttc ccagatagca gtaactatta tgcagtgact aatacgaccc accttaatag 100020
atatgaatag acttgttttg tgaatatatt ttaaaatata aatgtatggg attttgttca 100080
tgcatctaag aagctacaag gtacatttcc tcttggtgga gctatttatt tttctggaga 100140
gccaagacag gtacttctac ttctgtggtg taatttgagg ggttaggaaa atttccttgc 100200
cttcaatttt ccttccaacc tggatatcac aaatacacaa tagtagtcct caactttatt 100260
tttgttctca gtcacctgaa agacatgaca atccatactc tatattaatg cagcagtgat 100320
tctcaaatag agaagggctt taaaaattag aaatccctac tccatcttga aattttgatg 100380
tatctcccta gagtatgtta cttctctatg ctccattaca atttctcttt attgttgata 100440
gctgtccaga ttgaggggaa gcagagcaag atgcatctat tatatgtttc catctctccg 100500
acccattctc tccctttccc ctctacttgc tttctttctc ttttccctct tctgtttacc 100560
cgattctatt tctgattcca atatataaca gtttcccctg aaactctctc aataccaaca 100620
atcctaacta atggttttta aaagtcaaat acttattaag tactggaggg atagaatgag 100680
agaataccaa gactgataag atgcaaataa tacttttaac atatttacaa tctagtagaa 100740
agacatgctc aaatgagtta attattttaa tatactctgt ctctgagcat aaaatataat 100800
tatatatgct cattatagat gtataaaaaa taaacaaata ggtagaagct ttccatagat 100860
gtgtaatttc accacttgga aattacaagt tgttatagac tgttttgcgt gtattcactt 100920
atatccatca agtgactaca tttcaaggca ctacatgaga accataaata ttgtacaaac 100980
aggatttgct gaatgtcgtt ggagagtaac agtccatggg gctgattgtg atcagtttct 101040
gaggcaggcc tctatttctg ggtatgtatt ggtccctgta ggcttgataa actccctgga 101100
ggtggagatg atggagtagc agagctcatc aagggtatgg aggcttgaag gtacaaagca 101160
tgctcaggaa attttggcta ttccggtttg tctagagcac ttgttctcaa ccttacctgc 101220
tcgttactaa ttctactaaa tatagaatta aaagaagaaa aaatctgata actattttct 101280
cctgggacta attagatcaa aatctttgaa cccagacatt agtgttttaa aaagctcctc 101340
agatgtattg ttcagccagg actggggcag ggaaagctac tgaactcatc aagccttgag 101400
aatgagaaga acaagaagag aactttaaaa ggatttaggg gccacaatat gactatggag 101460
ctgaatttag atttggtttc gtaggcaaca tggaataatt tgtgtgtgag caggagaatg 101520
acacaatcaa agtggaatga taggaaaagt aattttacga gagagagaga atgagttgga 101580
agtaaggaac tcaggaggcc tcttgggact cagcagaagg ctctgaggcc accaaatggg 101640
tgtggtggta gtggaaatgg agaggaagag aatgtgaatg aggctgcaca gtgaactgcc 101700
agtgttagcc gtggggttag accggagcaa gacttaaaat ggttcgtcag ttttaactcc 101760
agaaagacct caaaaagagc ttttgtcttg ttatcatcag ctatatggaa ggtagaataa 101820
aaacttgtta ggagaaaaga taataaatgt ggcttttgat aggctgtgat tgagttggaa 101880
gggcatacca gtgaaatatc caacacaaag ttagaagtgt agaagagcac ttaggaggtg 101940
gctataagtg aaaatgtgaa aattatctac gttagaggga tagatgaagt cacagaagtg 102000
gatgacataa ttgagcaggt tatatgtaga ggaaagatgg gaaggttgag gacaaaatct 102060
ttagatggat ctttctcgga gtagaaggaa gaggaaatgt taaaggagat ttgattcaat 102120
gaaacaagta gatcagattt ctattcaaat atacaacaga tataattaaa acagatataa 102180
tttatttagt tttttttttt tttttttgct tggacagatt aatttaagtg ctttgtattt 102240
tattttcaac aggtgatggc agttttggat cagtttatcg agcagcctat gaaggagaag 102300
aagtggctgt gaagattttt aataaacaca catcacttag gctgttaaga caagtaagaa 102360
attcagtaat ataattatat taaattacac attattaatc tgctggaatt cttattttgc 102420
atacagttgt gaaaatgcaa aataatgacc acatttctac ttgagtttaa ttatgcaatt 102480
ctagtttgtc ttttctttgt agaatagaaa gttttgtgtt atttctcctg ttgagaaaca 102540
aagcactatg ttctgagaat ccttataatt gtgatgcata gtatgttgta aaaacttttg 102600
taagactcac ttaccctcct ctttttactt tagaacctta ctgttcaaaa tgtgttccat 102660
ggataagtag ccaggcatta tccaggagat tgttagaaat gtagaaactt gggatttttc 102720
agcgccatgt ttttgtcccc ggtgctccac agtagtcaga ctcctagctg cctccacttg 102780
cttccagacc ttgaagccta gcaagctcct gacttcacct tctattttct tcagagtgtt 102840
tatcttttac atttctggtc tagggagagt atgattttta tttttattga acatgacttc 102900
cgtgtgttca gagtgaaaga agaagtttaa tgcatgacct cacattgcta atttgattga 102960
aggtgagaaa tcttaaacca aaactctcac tgataagctt gcacctttct tttctggatt 103020
tatccacttc aataagaacc gctattgatt acttgctaca aagatggaaa agtcagcacg 103080
cttatcctat ttcctacttc ctgtccctgc ccacttccta aaatttaaaa ttggttaaat 103140
tagttttcct catgtataac aattataact tggaatgatt tacaacactt ttgatttttt 103200
agtacaccaa ttctagacag catggactga ctccttgcta tgtgagatga ggaaaattac 103260
tgccattctt tctcctcttc ccatcacctt ctcacgttcc ctaatttgtt ctattatttt 103320
tatgtagtga aagtttatca cgtctatatt ctgttctgtg ctcataatta aattgttcac 103380
attttgtcta tagtttggtt ctgaggacaa aaccaataaa tgccatttat atatattttt 103440
atttgtacag aaccaaaata tttctacttt tagacaaaga aatgcaacct tctgtcacta 103500
acttcttttc ctaatagaat agtaacagtc caaataacaa agtcaaacgg atcctctatt 103560
gttatgtatt tatcatcagt ctataaaaat aagggcatat tttaattcag gccacatttt 103620
taccctgatt taaaaaaaat tgtttttaga gatgcagtct cactaggttg accaggctgg 103680
tctggaactc ctggcctcaa gtgatcctcc caccttaacc ttctgagtac cagtggtgat 103740
ttattttatg tagctttttg aggttttctg attttatata tatatatatt ttaaaaaaca 103800
tacttcagga aaagatattt tcatcatgtc ttcaagtgtt tctaagttct taatcataca 103860
gtttgtataa cagaatctac tttcttcttg aagacattca tcattcagca catgacttac 103920
tgctctaaac aggagagatg gatttctagg ctgcttgcgc actgattaat ctatgagtta 103980
gtttccttgc cctctttgat tattctcaat gtttcttgga ttccatgcct tctcttggtt 104040
gaattgtcct tagtttttgt tgaagaatat ctttgaataa ttttttttaa gaaaaggtgt 104100
ttgtaaggta aatgttttca gtccttacat gttaaaaata tcttaatttt gcctcccatg 104160
tggtggatat gttatcacac tttatatttt aggaatctag gtttgaaata atttttcttc 104220
aaaatttgaa gaaaattccg ctgattttta gtgcccactg ttgctaatga gaagtctgca 104280
gtcagtcatg tttgctccta tctaagctac ctttaatttc attttaaaaa ctgaaaattt 104340
gatcttttga atttcatttg ttttcattgt tctgaacctt cacaagtata tgtttgtgtg 104400
taggttgttt ttcattccat ctaattcatt tttttgtgaa aaattatctt ctgtgtattc 104460
tcttctatta tttattattt cctccctaac ctttattaat catttttatt gacagctact 104520
atgtaccagg ttaggtgata ggatacataa tatacatata gtactaagct aaacccagtc 104580
aagcctctcc ttctctggag cctatatcta gttacttatg attcattatt gcttgccatt 104640
gctccaagag tatgtattag atgacaagcc ttctgggtct atctcatcca tgtttgagtt 104700
ccctcttcaa gttttatcta taatttgtgt tacttacttg actatctctt gcaggtttct 104760
agtttgtttt tcagaattgc ctcatctatt atttagtttt ctgctgaatt ttgttttgat 104820
aatcatatct ttcacttcca gcaattcttt ccatcgcctc tccttgttct tttgtagcca 104880
tatttttgga tgaaataccc tcaagtgttt ctgttcacat caattggaat ttaatttttt 104940
gtattacttg cattattgct gttttctctg aggtcatttg ctctatgggt tcaccttgat 105000
ttttctcttt tatattgttg gttttccaaa ttgagtagtt ttggatgact tcatatctat 105060
gaagtgagta ctatattgat tatcaaagat aactagaatg ggcattcttc acatttatgt 105120
aggtttgctt gttcaagtta ccactttctg aacaagaagg tagaccatag acttttaagg 105180
gctgtgtact gcttagggat actctgtttt taggttacat gggcagggat caccaggact 105240
gctgagacca tacctagcaa aggaaggcag gctaacgata gttgatgagc taaaaaaaaa 105300
aaaaaagaaa aaaagtaaac aaaaaaatct cataatgttt taagaaagtt tatgaatttg 105360
tgttgggcca cattcaaagg catcctgggc cacatgtggc ctgcgggcca cgagttggac 105420
aagcttgttg tagatacttc agactctgtt ctacatctct tcatagatcg ataacttgct 105480
gcaatgagct tatcagagaa attatcttct tttcatccat aaaaaaagtc atgggaggta 105540
ctcactatag gattggttta ttccagtgac tctggccaat tttctttaaa attcctttaa 105600
ccttgttata ttggtttaat ttcttcagaa tgacttttcc cattgtggta aactggttct 105660
aggcttcaca attacttatt ccaagtacag gagaaaagag ggcacctctt ttgaggactt 105720
gcatttcaaa ggaatcaaat ggcctacata acaacccatt aaataaataa atgtctctca 105780
gcaccagttg agtcacctgt gcttttctca acaagcacta tgttcagggc aatgctctgt 105840
gctaattggc tttaggtctc tgttaccgaa ctgatcactg tggccctgag ggtgctatta 105900
cttagaatat tctcaccttt tctgagaggc tgatgttggg gtcagttcca cctgaactaa 105960
agtccatggg ctgcatgggt aaaggttgag tacctcagca aatatcatgg aaaggaaggg 106020
gaatatacac tgttagttaa cagtggttac tcctgtactc tctcttgttt ggatactact 106080
gggtatttat ttctttttct gagtctttat tgacattagg aatgagagat agaaataggg 106140
tgagagagga agtaaaatca atgctaattt ttccatctta taccagaact caactgtatt 106200
tctggaatct atgtatcctt acttttcctt tgatttatta caaaaaaatt cttagtggct 106260
acactaaaaa ttttgtaacc tttaaaaaat acatagttac actacttcag ttactctgag 106320
taatagaaaa tttcatgtgt gtacaaaata tcctgggggc attttaatta ttagtaacta 106380
cagtcacagt gtagttctag aaccaaatta aacattttgc atatagaagc ttatctgtga 106440
aacaaatctg gcacaatctc ttttaatgtg taggtaattt gttatataaa ttgatttttt 106500
agctttgttt gttacttgtc agcatgcatt tcaaatttta cacaatgtgt ttggggaact 106560
ctgatggaag tcagtgcatt aaaaatgtct acagggccaa ttagtgtata ggcagggagg 106620
caaactaagg gaatggtgga agaaattgga aaaaaaaaaa aataaccgat gtgcataatg 106680
tactacttct cgtaaaaaaa aagaaaaaaa gacaacaaca taaagaaata aaaatgacat 106740
ttgatggtca ttctgccagt agtcatgggg cagatctatg ttacactgta ctattatgct 106800
cttttttcct tgcaatcagt gagttgcttt tccaggatag aaaatttgga ttaggcctct 106860
gtctgtgcct gtgaaaataa gtagagctaa cttaactcgt tctcatcagt tttaaccaac 106920
tgagctaatc agacatgggc attaaaaaaa gattttatct actaagcaaa tatgatcaca 106980
gtctgaaact ttgttcttgg aaaatcccct ctcagggtgt tcagcctttc ttcttcagtt 107040
tgcagaattc tccacgtttc agtttcctga taaatcagtg ggtgctgcta ctccacgtct 107100
ttgaagctgg ttgttaagaa gcagcacttc tacagcgatc acagtttaaa gcatgaatca 107160
atttaacatc acataagcta taaatttcaa cggagttaca gtttcagagt aaagtgcaat 107220
atacagtata aagtgaatct ggaattcaag cccaacaatg tcataaaaga ggctgtgaag 107280
tctcacatga tgtgggccac agagaggatt gttgccattc agatcttagc tcaaatacta 107340
ccacatctct tggagtggcc cgccaggggc cacccttact aagccaatcc ctctgttcaa 107400
gccaaaatga tatctcagac tttttttgaa ttgcagagag attgttgcag ccagggattg 107460
cattagtaag ggtggcccat ggtgggccac tccgaaggat gtagtaatat ttgagctaag 107520
atctgaatgc caagaagact tcagccatgt gaagggtgga gggatttctg gggagagggg 107580
tcagcacagg cgaagaccct ctgacgggaa gaagctgagc acagcttggg attgaatgaa 107640
tgccagtgtg gctgaagggt ggtgaatgaa ggggagggga aaaggagaag gtctgggagg 107700
cctgggcatg atcagatcag gcggtgaggc catggaggta gatgggattt tcatctaaga 107760
aaaataagaa gtcttcagag agttttcagg aggggatgat atatatttct ttgaagttga 107820
gcgttatcct cggtaaattt tgtagtcatt aaaccagaga ttatagacag attttccctc 107880
atatgccagt tgcagctgat tagtagtggc tatagagaat actgggctga gaaggattct 107940
gtggctaacc agaattcagt agacgagttt gacatggccc attagtatga ctgtactgtg 108000
tgcactgttt ctgcattaaa tgtctgacaa aagcagagcc aaaggaaaaa tagaacttaa 108060
caatttaatt ctgacaatac agttgaccct tgaaatacat aaaggttggg gtgctgaccc 108120
cttgtgcagt caaaaatttg catataactt ttgacctccc caaaatctga accactgata 108180
gcccgctgtt gactggaagc tttgctgata acacaaacac ttgattaaca catgttttgg 108240
atgttatctg tattatatac tccattctta ccataaagca agctagagaa aagaatattt 108300
tatttaaaaa atcataagga agagaaatat atttactctt cattaagtag aagtgtgtta 108360
ttataaaggt cttcatcctc atcatcttca cattgagtgg gctgaggcgg gggacataga 108420
ggaaaggtgg gtcttggtgt ctcaagagtg gcagaggtgg aagaaaattt atgtatatgt 108480
ggactcagac acttcaaacc tatgttgtcc aagggtcaac tgtagtttca aaaccagctt 108540
tttatttctg aaaatatgtt taaaaaactc agagaagaaa tggaaagttt gctatgatcc 108600
agtcatccag agaaatccat ggtcaccctg ttgatgcact ttaaagaagg agaaacgtgg 108660
gtaagacctg atggtgaatt actcttatat gattttggac ttttgcagga gctggtggtg 108720
ctttgccacc tccaccaccc cagtttgata tctttgctgg cagctggtat tcgtccccgg 108780
atgttggtga tggagttagc ctccaagggt tccttggatc gcctgcttca gcaggacaaa 108840
gccagcctca ctagaaccct acagcacagg attgcactcc atgtggctga tggtttgagg 108900
taagcaggtc ttgttgttta atattcagtg catgacaagt gtgaccccag acttactctc 108960
aggttccgag aacacttccc agtaacaccg tgccccagta acaatttaca aacaatttgg 109020
atgaaaacta ccatttccct gatcaaattt ggttaatttc agaaaataag agtatgaaaa 109080
ccatgtagaa cctcatagca agtagtaata gactttgaac ccacaagttc agctgtggaa 109140
cccataattt taaccctgta ctgatctgcc ttctgtacaa atgtataagt taggcttcac 109200
agtatcaaat tgagtgtcaa ttacatgatt ccagtgagga aagatgagtc catacttctc 109260
aaggggacta gagtgattca cgttggattc ttcggtatga ccatctcaca tgtctcagag 109320
gtacacctat ccacgcagcc agagcaagct ttggagaggg agcacactgg agtggaaagc 109380
ctgttgtctt tgaaggcaaa acgcctggga ttaatcactg ttccacacac ttagtaactg 109440
tgattttata tctctgattc ccatttttta aatagtgtgt gaaccatgac ttatatttaa 109500
tgcataaaat tgtgatgacc tctgtaataa tggaagacat tccagatgaa actcttgatg 109560
tccgctctgc cattgctccc caaccccagt cacctcttta cacctgagag tcacctttca 109620
ttcttttctt tctctctcat ctcatagcta atcctttagc aaatctttca gctctgccag 109680
caaaatatat cttaatgctt ctaacaattt ctctcactaa tgtctgagcc agtatcatct 109740
ctcattgcct ttcggtcccc tgcttctatc tctgtctcat gatacatccc gttcttcaca 109800
cagctactgg ggtgattttt ctaacatgaa agttggatca ggccttgttc ctgttatcaa 109860
ccctcccctg ccttatttct tgggcagggt gctcagccac tcctatccct gaggttcctt 109920
gcagatacca gaggctttat attggctatt gatttcactc aggagtgtct gactcccaga 109980
tatgttctct acttattata aaggattatt tgaatccttt cattcaggac tctcagcaca 110040
gaggatgtcc ccgacgaccc tttgtctctc cagcctctat aggagtattc ctgcctagga 110100
ttttttatgt tttcattttt taaaaattta tttattgtct gtcttgccat cagaatctaa 110160
gtaccattaa aggagggact tttcatccta ttcaccattg tatctctagc tcctaaaata 110220
gtaagccttc agaattattg tgttgacagt aggggaagag ggagaaagga ggaaagaagg 110280
aaaacagtgc ctggtgcata gtagcaaagc agtgtatgta actttccttc tcttctgaaa 110340
tgctatgaat atgcctttta ggtagtatcc agaaatgtcc cttcctgaaa gggtccagaa 110400
actactgaaa actgtccaga ttatgaaatg aaacagggtg cagggatttg catttgagtt 110460
gatatttctg cttttgaaca ccagggggaa ccttgggtta aattaatgta ggtaaagtgc 110520
agcttagtct cctgtatttc aatgccctct ttccttcatt taactaactc taggttcagt 110580
ttttccctaa ttcttccaca aatccgcaaa gtgtttattt ataaagtgaa gaattgctat 110640
tttttttttt tttttttgct taacactgtt cgaaacacct tgtctctaaa atgacttatt 110700
ctagttctgt gaaaccttac tttaaacaac aaatccagca gtttctgatg aagtaaatga 110760
aatgtcagca tatttaaaat aatttgccta atttgttctt agcttaatgc cagaaaagat 110820
ttctggattt tgtatcacaa aaggctagta gatttcagta tctatcaatc ttctaccagc 110880
actaagtaat ttttaaaact cagcattaag gtttattttc ccaagtatgt tttagcacag 110940
aaaataaaat catgctcctt tggagtccct tgaacgctgg agctgtttag agtgacatac 111000
aagaactttc ttcactttac atgctctccc tccatcttgc ttttacctgt tagcttacct 111060
ctccaatcca atccacttcc tttgaacgct ttatcataat tctataaaac ttaagaaaat 111120
ataatcacct gcattttcta tatgtttctg tgtttcagta tcttcaaaat ggaatgtact 111180
gccttggtac atcacccact ataaatctat tatttctgct atatcccaca cttgccaggc 111240
caggatactt gttgcctcat ccaggccaaa caccattccc aaaaagcaac tatgcatttg 111300
tccaccaggt ccttgactct attttacatt atctttttag tcaattcatt tacttttatg 111360
ctgcttactg ctgccttggt tcagcatgtc cagggaatta tcagaatttc ttttctaaaa 111420
taaaaatcaa tttatgcttg caattccgtg gcagttctca attatctgca aagtgcatcc 111480
aaactcttgg catagcatca aagctctttc tgtatgcctc ttgcttccct ttacagcccc 111540
tgccacccta ctgcccacac tgcattctag ccatgatgac agtcttgaat tttcagttat 111600
gctcatgtct ctccgtcatt gtatttgtta ttcctctctt tccaccaagt tgtctgccta 111660
gaaaactcat ttttcttaag aatttcctca catatcatct ctactgtgaa gctcaaatgt 111720
gtcatgaagt gttagcttct ccaacttgtg tttcttgcac atgctctgtg taagacattg 111780
tcttaggtgc taaagagaga aagctagata ttatattgtt cttgaggttg aaagcttaca 111840
gtctagtggg agactcaact ttgctgtctt tacctcaatg tttttcttcc tctgtgcttc 111900
cctagcatgt ggtagttaca tatttctgga accttgtttg aacacctgtt tgaggactgt 111960
ttgagcacaa tccttctgga ttgtgacacc ctcaagagag cagatataca aagatggctt 112020
tgtatactaa atgactggcc ctcatagata cctagtacat atttgtcaaa tgaatgaatg 112080
cattctattt ttggaataat tctattcaga atgagataaa gtttacttta agctatgaag 112140
aaagaagttt cttagcaact cttaaaataa tcacaaagaa tgactgttta acttaatata 112200
aaccagtttg ttttaataaa atatttgaca atagtcatgg ttacacaatg cataaattat 112260
gactaaatta ttgtcaggaa ggaaagatct ttacttatta tttcaaaagc tattttgcta 112320
gtctattaaa agctattaaa actgcacttc ttaagattaa attctataat tgaacatttt 112380
aactaaccaa gatattatct ctttcccact gacattattt caaattaagc ttaactattc 112440
ctttttagcc tttggaaagt attctgagtc tgtgttctat aaatatactt agagaggcat 112500
gtcttataaa ggatttggat actgttcagt gatgtatgac ttggctttag tttttctatt 112560
cttaatctct cagcttttct cttcagcatg gcaagagtac ctaatggcct ttcagtaagc 112620
ccttagtaaa tttttctttc aagcccatta cttactgtga aggtcaactt cattagtgta 112680
tttatcttat ttttttcagc ccaaaatagg tatattgaaa tgaatgggcc taatgtcaaa 112740
tgtcccaact acatcctgga agagagagaa tcttctgctg tattagttga tgcaattaaa 112800
taatatgtac tctccaggcc atcatacaat tcaaagttca gggtatcatt gccgttctct 112860
tctaatcctt ccagaagtga ttggtactag gtaatggagt aactattaat tgatataatg 112920
tgagccaaaa ctaacagtca cgaataagca aagaatttaa atttaactcc attaagtctt 112980
gtgaaaaatt attttcaacc taggttgtca catagctgtg acatcacatc aaatgctgta 113040
gtcaatttga catcatgggg cagagaagac agagttggaa atcagaattt tatagacata 113100
taatgtgata atagcattag tagctgagac acggtaagct cactgaccat gtttccagaa 113160
tggataagac ctggttgaga tgaaaacttt atgttttttt tttatattaa ctagctttta 113220
ctctttgcct gaaatgttca actctagttg ctcatgattg cgtgggttag tctccaaaag 113280
gatggaattt aatgttaccc atcatctttt ccaagacaat gttttattca ttctaactca 113340
gcccaaaata ctctttttta accttaatat ctaacatgat taggtttatg gtaaattata 113400
tactcaaaca gaagaagaga ctaatagcaa gcaaaagtct tatattttca tttgttttca 113460
tccaaaaagt agaaaatatt ttccaaacat tgggaaacat tttagtcaga aaaataaata 113520
tcaatggtaa ataggataga gaaaaatttt aaatctgagc taaacctcta tatggtttta 113580
agaaaatcaa aactattaaa taaatggcaa gtacaacaaa atcccatcaa ttcttattta 113640
acttatttga aatagctaaa atattcacat gatcattgag ggtattcaga attgccttta 113700
agtaattgtt catatatact aaagaaaagt ctccaaaaat tcggtctttg cctgagatag 113760
atttgtctta aaattgaaat cattcgctta tcagatttga ccgtttttta aagcgtaact 113820
ttactttgta atattagact tgtatgtttt gattttcttc tataatacca cttaacttta 113880
agggtcaaag tgagcacaga atttttgatg cttggcataa tggacatgta tatttaagga 113940
aattaggaga gaaattatta taatgtaatc acatttgaat aagatttcct gtgcattttc 114000
tggcagatac ctccattcag ccatgattat ataccgagac ttgaagcccc acaatgtgct 114060
gcttttcaca ctgtatccca atgctgccat cattgcaaag attgctgact acggcattgc 114120
tcagtactgc tgtagaatgg ggataaaaac gtcagagggc acaccaggta ggtgatcagg 114180
tttgtctcat aattctgtct tcaggatgga taaccactga cctcagatgt gagttcagaa 114240
gagtcaaaag gaaaccagag tctatcacat tgcgaacaga ggtttactgt gtgaaaaatt 114300
gcaagcatta cattgtgatt tttatcattg tattttgtag gaaaaaagac aattgaggta 114360
atttttcagg gcaaaaactg aataaaaaag aagagaacat ttgatatcaa gttatatttt 114420
tataagttag atttttagat tctttagata ctctagaggt tgtaaaaagt aacagcaaaa 114480
acttcagtct aggtactgtt gacacttgtg aggcaaatca aattcaggtc cacagattct 114540
ttttcataac tctgaaatcc acaaattctt tttcataact ctgaaaaccc caagtttttt 114600
ttttttaata actaatttgg tgtcaaaacc taagcaaact gacttgatgc ttattacagt 114660
ctttatttct catgcccagt gtgaatatgc gtacattttg ctgcagaaat atatacatgt 114720
ttgagtacag ggggccggcc ctgacccttg aaagggtttc tgtgcacatc actaactacc 114780
ccatggaata ttccctccct ttctcagttc ccactccact tcttcaactc aaattcatca 114840
gaatttcaag ctcagattcc taaaaagcag ttatggggcc agtgatctgt acagacatgt 114900
tgtctcagac atcagtttga gcaggaaata caacatttag gggttggcat ttgtttggag 114960
ggggggatca ctctatcttt agggaaactt tatatagtta gttatttgta agtaaaatta 115020
caggtggcta tacgtcatct tgatgattgc aactcaatta aatcaccatg cctgacacag 115080
aagaaaatat gctagaggat atctcactag ggaaaaggtt ccagttcaat tcttgcccac 115140
tcaacttttg tatttagata aacaaatggc tccagattcc aatgcctggt tttatttttg 115200
ctccaaatac atatatactc ttttgttttg cataggtaca ttttagaagt agactgtgta 115260
ttctcataaa cacttcaaag tgtatgttct ggctgagagt gtctttgtgt agttcaatga 115320
aattaattat aatttttttc agtaccgtgc tgtgcgtcag gcccagtgcc aggtatatta 115380
gagacaagat ctcttatcct catgccaggg ctgaaagtta gctattattt tctcatttgc 115440
caaatgagaa aactgaggct cagggagatt atataacttg cagaatatca ctcagtaatt 115500
ggccgagata agaattcggt ctgaatgaga accagatcca gagatatttg gctttaaatt 115560
ctatagtctc ttctaaacca tatgtgactc taacatgaag aagcttattt aattttccct 115620
attaaaaaag tcaaaacaaa acaatagagc catgaatagc aaatattgtc aatgagaggt 115680
ttggaaaaac aatcttaaaa gatgaaattc catagacctc atatattcct acctgaaaaa 115740
agtgggcaca ggacaatgat tttcttttgg aagatctgct catttttgtc atgggacatg 115800
aaggtggact ggaccactca gtttcttctt tctgcatctc ccaacccagt ctttctgttc 115860
atggggtgaa aatctgttgt tgaagccttg tctacttaat tggacagtgg aactctcggg 115920
tctctatggg ctgtgttctt gtacttgggc tctgcttctc tgctctgtgg tctgggtcag 115980
ctagcagcca ctcagttcac cttggttcag actcatggcc tttcattttc agtatctgat 116040
ttctggtttt gctcaatacc tgtctaaaat gtaataccca tctgattctt cataccaagc 116100
gacacaattg ctcctgatcc cttttaatct ccaatattga atggtggtaa cataaatatg 116160
gagacagatc atgacagaaa cccagggcct aatcttttgt gcccactctt ctcacaggct 116220
tcttaatact ttggaagctt tttttttttt tttttttttt tttttttttt ttttttcggg 116280
ctgtaaccta gattttccct ttatcattac tctattattg ttagagcact tctaattatc 116340
ttagccctaa actctgcctc caattttaaa taacaataat tctcactcct actaatactg 116400
ctactagtac tactgtcacc aaactttttc ttccccaaag cagttctgtt tgggaagaaa 116460
acagttccct ctcatacaat ttcagttatc ttcttgtctt ttctgtttca tgaatcttcc 116520
tgttaatgtt acatctttta acatggaaac ttctagagaa acaaaagacg atggatttgt 116580
taaacttttt gggtgcagtt ttatacgaac tcttaccgaa gtgtgtgcat tatgagtgtg 116640
ggtccattac agctgtaata ggagcagaac cttccagagc atgagcgatg tgctgggctt 116700
gtgcttagct ctgtccatga gttgagcatc tcaatcctta ggaccctctg atatatgtgc 116760
tattactatt tctagtctat agatgcagag actaaagttt agagagtatc aaaaacattt 116820
acaaggtcct ataggacaaa actgtaagac aaaatgcata cccaagcagc ttgagagcag 116880
agctcctgtc cagcactgtg atagctgggg acgcagaaac ggaaacaatg caattattga 116940
caagggccgt ggtgccatgt ctgtccatat tttgaaaata attatggtat ggatattttc 117000
acctttaaat aacttggaga gtttcaacat taactcagtc aaatggatat atttatatca 117060
tatctggttg ggagtgacag ttaattctgg gtcctgtggc aattgcactt ttaactgaga 117120
tgaatgctga ctgatggctt taacatttaa ctaatgtgat attatttaac acacccacat 117180
aaatactaca gtctttgggt aaataaaatg ttactggctg gacatacacg aatatctgat 117240
ggagattatg gaacatactc tactcatatt tctctgaaag taaaaaataa agtatatgtt 117300
tcagtacaca atgtgatata tactcagact taattcataa atttctctta ttcttcatct 117360
atggatcctt tatttattta cttattgcat ttgttaaaat acaagcttct ctgaaaaatt 117420
atttctaaaa atagttttta gacaatcata ttttctcaag tattttaaca ttatgatcat 117480
tatgataatt ctccaagggg aaattatact tattttttat tcatttattc attcatttgg 117540
caacaatata ttgaacattt accaagcacc aaactggctc taccgcttaa tagtggcatg 117600
acgttcatca ggaaattgtt agtgcaatca agaacactag agattcactg ggagaattta 117660
aattagcttt tagaaggata ttatattaga attgaggcac ttgatgaatc tataaataat 117720
actatgtttt catgctagag atcgtgccaa tgaagatatt tactttgaaa aggggaagat 117780
gagaagttta aaagcatttc catattgaag taaatattca tttccatatc ttcacagtta 117840
tcttctcaga gttctctgac tcattgtgaa aaaaaattcc aaccttctgc acagctctac 117900
gatcttcaga ttgttgccta gaggggtaaa atctattcta aaaggaggtg tgcactggat 117960
gagaatttag aattagatga aataacccct agagtctttt cctgctttaa gagcctgtga 118020
ttccaaattc taacagtgca tttatcaaga aaaaaatatg ctgaacattt tagtagtttt 118080
tgaatagtac ctggataaaa tagataccta ataaatgtgc tcaatgaata ataaataact 118140
gattaagatt taaataaacc tcccaaatct ctttcacatt ctaagatggg aagcataaag 118200
gttgttaatg aactagtgac tgcgtgggta gctcattatt tttaagtact cttgactttg 118260
ctgttcatta tctgtgtggc cttaggaaaa tacatatatt tctgaaagga ttatgtcatt 118320
tgtaaaatag aaagtcctta tctgtctacc acagatgatt cttgtgcata tcaaaagaaa 118380
tattcaataa ggcatctgta aaatagtaga gagagatgaa ttaggggcta ttgtgattcg 118440
tttacattat gtcacaggtg cactttatta gggatatgtt ttagagctgt cttaattacg 118500
taattcttta acttagattg tgagaatgat attatggtta tataggaaaa tacccttatt 118560
ctaaggaaat gtatatttat gtctgaaaca ttgtatctgt aacttaatat agtatataaa 118620
ttatgctaat ttacatgata attatatgta attatattac tatgttacta tgtatacaat 118680
ctatttacat gcatgtatgt gggggaatgt tatcctcggt tagtgtagta ggagttatca 118740
tgctcaaatt caatatctcc acccttccaa ctcttcatgc ttttctagca tggtgaggac 118800
tgctgaactc catcttttgc tggtagtctc tctgtcaaat agaactgttt ccaaattcag 118860
tcatttactc cttgaaggct atgaattcat actttgttat atttttctgg ctgcatattt 118920
aaattactct tacaatcata taagttcatt gtaaaaattt tcgaaataaa aaggaagata 118980
aaatgtacag ataattttag caaatgaaat aataattcta ttgggatgtt ttcttcttag 119040
attttaatta tgtacattcc catcaacttt ttattttgaa aatgtttaag cctacagaac 119100
agttgaaaga acagtacagg ccaagtgcag tggctcctgc ctgtaatccc agcactttgg 119160
gaggctgagg tgggtggatc acttgaggtc aggagttcaa gaccagcctg gccaacatgg 119220
tgaaactccg tgtctactaa aaatacaaaa attagctggg catggtggtg ggcacctgta 119280
atccctgcta ctcgggaggc tgaggcaggt gaatcgcttg aaaccaggag gcggaggttg 119340
cagagagccg agatcacacc actgcactcc agcctgggca agagaatgag atctccatct 119400
caaaaaaaaa aaaaaaaaaa aaaaagaaag aatagtgcag tatacactca tataccctac 119460
acataaattc attgattatt tactttttgc cctacttgtt ctttcttgct ctgtttgcat 119520
atgaatgaat cgctgaaatt aagttgtaga catcatgcca tgtaatctct gaacagtgtg 119580
tgtgtatttc tttagaataa ggatgtttaa tccagtctgt cactgaggga catttggatt 119640
gattccaagt ctttgctatt gtgaatagtg ccgcaataaa catacgtgtg catatgtctt 119700
tatagcagca tgatttataa tcctttgtgt atatacccat acaccatgga atactatgca 119760
gccataaaaa gggatgagtt tgtgtccttt gtagggacat ggatgcagct ggaaaccatc 119820
attctcagca aactatcgca agaacagaaa accaaacact gcatgttctc actcataggt 119880
gggaactgaa caatgagatc acttggactc gggaagggga acatcacaca ccggggccta 119940
tcacggggag tggggcggag ggagggatag cattgagagt tatacctgat gtaaatgacg 120000
aattgatggg tgctgacgag ttgatgggtg cagcacgcca acatggcaca ggtatacata 120060
tgtaacaaac ctgcacgtta tccacatgta ccctagaact taaagtataa taataataaa 120120
aaaaaagaat aaggatgttt acttacatga tcataatacc attatcacag ctaagaaaat 120180
aattcagttg attttttcca catatttgat aactttctgt ctatccagga ttctatccta 120240
cattttcttt taatttatgt catagcatat catcttagaa agtgatcctt aagttactgc 120300
atggtataca ttgtttaatt gtttaaccat ttccctttgt gattggattt ctttaggttg 120360
tttatatttt tattattatc acaaatgttg aaatcactct ttttttctga agaatttaaa 120420
agtaatttat ctctcttgtg gaataaaaga tttatttccc cttaaaagaa tttcaggcat 120480
gaacccaaga gagaaggcat tttttgtttt agttgttgtt gttattttta ttttttattt 120540
tttgggtaga aggagcaaag tgacaagttc aggaaataat gagagtgtta gaattttggt 120600
caggttaaag tgagttggag tgaagtttag aaatctttct gctcatctct cctgttttta 120660
aaacactgtc ctggaaatag ttaatattag gaatgagaaa aatgatatag gttttcctag 120720
taagctttat ttcttaatta tgaaatacta nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 121980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 122940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 123960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 124980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 125640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng ctgaattagt 125700
ctgtctgacg agacacattt tattacctaa aaacgtaatt gttgactgca tggttgctac 125760
acatcacaac agcaggaatg caagcatttg gctgggctgt gggcacacca acagaggaca 125820
gctctcattt cttgacttaa atactgaagg atacacttct gaggtaaatc caatgctctt 125880
taaatctttt gtaatttaaa gcatatacca gttagaaagt tacttaggga taatttttta 125940
aatttatttt gtacaaagta aaaatttaca aattttactt ttacaaagta aaaacaaaag 126000
tataaatgtt ttacaaagaa aataagagcc aatgtaggaa tattattcaa ttagccttct 126060
gttagaacaa gagtattcag ggggacggag caagatggcc gaataggaac agttccagtg 126120
tccagctccc agcgcgagtg acacagaaga ccggtgattt ctgcattttc aacggaggta 126180
ctgggttcat ctcactaggg agtgccggac aatcggtgct ggtcagctgc tgcagcccga 126240
ccagcgagtg ctgaagcagg gcgaggcatc gcctcacctg ggaagctcaa gggggaaggg 126300
aatccctttt cctagtcagg ggaactgaga cacacaacac ctggaaaatc gggtaactcc 126360
caccccaata ctgcgcttta ccaagggtct tagcaaacgg gcacaccagg agattatatc 126420
ccatacctgg acgggagggt cccatgctca cggagcctcc ctcattgcta gcacagcagt 126480
ctgcaatcta acggcggctg ggggaggggc acctgccatt gctgaggctt aagtacgtaa 126540
acaaagccgc tgggaagctc gaactggcta gagctcacag cagctcaggg agggctgcct 126600
gtctctgtag actccacctc tggggacagg gtacagcaaa acaacaacaa caacaacaac 126660
aaagcagcag aaacctctgc agacacaaac gactctgtct gacagctttg aagagagcag 126720
tggatctccc aacacggagg atgagatctg agaacggaca gactgcctgc tcaagtgggt 126780
ccctgacccc tgagtagcct aactgggaga catccccact aggggcagac cgacacccta 126840
cacctcacac ggtggagtac acccctgaga ggaagcttcc aaagcaagaa tcagatgggt 126900
acacacactg ttcagcaata ttctatcttc tgcagcctct gctgctgata cccgggcaaa 126960
cagggtctgg agtggacctc aagcaatctc cagcagacct acagctaagg gtcctgactg 127020
ttagaaggaa aactaacaaa caggaaggac acccacacca aaacccaatc agtacgtcac 127080
catcatcaaa gaccagaggc agataaaacc acatggatgg ggaaaaagca gggcagaaaa 127140
gctggaaatt caaaaaataa gagcgcatct cccccggcaa aggaacgcag ctcgtcacca 127200
gcaacagatc aaagctggat ggagaatgac tttgacgagt tgagagaaga aggcttcagt 127260
cgatcaaact tctcagagct aaaggaagaa ctacgtaccc agcgcaaaga aactaaaaat 127320
cttgaaaaaa gagtggaaga actgataact agaatgatta atgcagagaa ggccataaac 127380
gaactgacag agatgaaaac catgacacga gaaatacgtg acaaatgcac aagcttcagt 127440
aaccaattca accaactgga agaaagagta tcagcgattg aggatcaaat gaatgaaatg 127500
aagtgagaag agaaatctaa agaaaaaaga agaaaaagaa atgaacaaag cctgcaagaa 127560
gtatgggatt atgtaaaaag accaagtcta cgtctgattg gggtgcctga aagtgagggg 127620
gaaaatggaa ccaagttgga aaacactctn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 128940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 129960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 130980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 131940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 132960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntgag ttgtaggttg 133020
gtgtctgtaa tggggcagga tgatttccag gaggcattaa gattatatac cccatatatt 133080
tctctggttt aagttagtat tggaaaaaaa gtattagaaa aatgtgaagc ctgtttttgg 133140
aacctgaaat atcagctcca ctggcagttt cggagttgaa attatttgaa tatggtcaaa 133200
gaaaaatttc aatggatggg attgggccag gaagacttta ttcaagcctg tcacaacagg 133260
ggagagagat ctgattgaac taaactccac tgaaataaaa ggtgggagaa ttttaagtgc 133320
aggggtgagc taatggaaaa gtacctgagg atgtgttgtg gggaagtggg agcagttgtc 133380
aatgtgatta ggccatctgt gcttgctaat tgtcccttct tgaaggtagg ctcctattct 133440
cctacagaca ctagagaata gtcgtccttc cttccttcct tccttccttc cttccttctt 133500
tccttccttc cttttttttt gaatgagttt tgctcttgtt gcccaagttg tagtgcaatg 133560
gcaggatctc ggctcactgc aacttccacc tcctgagttc aagcgattct gtagcctcag 133620
cctcccgagt agatgggatt acaggcatac aacaccaaac ccagcaaatt ttttgtgttt 133680
ttagtagaaa tggggtttca ccgtgtcagc cagactggtc tcgaactcct gacctcaggg 133740
gatctgccca cctcggcctc ccaaactgct gggattacag gtgtgagcca ccgcaccagg 133800
cctctttctt gataattaca tttcaaagga atggctccca agtccttgga aaagacattc 133860
ctggggtata aaactggaaa gagtctggga aaaggggcag agaaagaatt tataattgca 133920
agtcttctaa agtaaatact ctaagaaaag ggaggttagg agtttatagt tgagaagtct 133980
atctaaagtt taataaagcg gaggagaaca ttaaggccat tttagccaat gtacatgttc 134040
tttttgtaac aatttcaaca tttttccttt tagcaaacaa aaaaattttc ttttggttgg 134100
aaccgctgat ggcaatttag caatttttga agataaaact gttaaggtaa atgttgaatg 134160
cattctacat ctaaatttat tttaagtctt ttgttttata tatatctcac tgccctctta 134220
tgggattata aactccctga gagcaagaat cataaattat gcttatattt gtattgcttc 134280
ataaagtctt gcacacagta gatcctctga aaatacttgc tgattgactg tatattttat 134340
atgaatgaac taagaataag atgataaatg acatctgatt gataatgtta ggaatggaaa 134400
taattcaatt tgtacagatt tgtatctgag gcagataaga taattcctta taaatatatt 134460
gtgggaaaaa aaaccaaaaa gatacttaag ttttaaatat gacttgccat taactttttc 134520
ttaagcattg aagaaatcat ttaattttgt gttcttcaga ttcttattta gtcattaaag 134580
catttattcc tctatccatc tattcatctt tggttccatc tattcactct acttcctacc 134640
cgttcattct cctattacca aaaagcttat tatctgagga gagacatgga agtagactat 134700
aataaccctt aggttatttc ttatgtaatt tttacatggg gaaaaagaat agattgaatg 134760
taacaataat attttgaata tgacttaaat tttttaatat atagtatttg tacatattta 134820
tggggtacat gtgatatgct gttacatgca tagaatgtct aatggtcaac tcagggtgtt 134880
taggatatcc atcaccatga gcatttattt ctatgtgttg agaacatttc aagtcttctc 134940
ttctagttat tttgaaatgt ttttaactgt agtcacttta ttgtactatt gaacattaga 135000
acttattcct cctatctaac tctgtgtttg tacccattaa ccagcctctc ttcatcctcc 135060
ccttctccca cacacccata tccttccaag cctctgataa ctatcattct actctctacc 135120
tccatgagat caactttttt agctcccaca tatgagtgag tacacgtgat atttgtcttt 135180
ctgtgcttgg cttatttcac ttaacataat gacctccagt tccatccatg ttgctgtata 135240
tgacatgatt tctttccttt ttatggtcaa atggtattcc attatgtaaa cacacacatt 135300
ttctttatgc attcattcat tcatgggcac ttaggttgat tccatttttt agctattgtg 135360
aatagtgctg caataaacat gggtatatag gaatctcttt gatatactgg ttccctttcc 135420
tttagattag tatcagtagt gacattgttg gattgtatgg tagttctatt tgtagttttt 135480
tggagaaatc accgttctgt tttccgtagt ggctatagta atttacatac ccaccaacag 135540
catatgggca ttccgttttt tccacatcct tgccagcatg ttattttttg tcttttttac 135600
aatagtcatt ctaaccgggt gaagaagatc tcagtgtggt tttcatttgc atttttactg 135660
atgattagtt aatgttgagc attttttttc atatatccat tggccattac tatgtcttct 135720
tttggaaatg tttatttaga tcctttgcaa acgttttgtt ttgttttaag acagggtctc 135780
gctctctcac ccaggctgga gcacagtggc atgatcatag ctcactgcag ccttgacctt 135840
ctgcactcaa gtgatcctct aacatcagct tcacgagtag ctggcactac aggcatgtgc 135900
caccatacct ggctatttat ttttattttt tgtggagatg ggaccccact atgttgtcca 135960
gactgatctc aaactcctgg gctcaagcaa tcctcctgcc tcatcttctc aaagtgctgg 136020
gattacaggc atgagccacc gcaccctgct ctttgtctac ttttcaatgg ggttcttttt 136080
tttttttttt ttttctgttg agttgctttt tcgagtttct tgtgtatcct ggatgaatag 136140
tttgcaaata tttcctccca ttcaacagat cgtctctata ttgttgatag tttcctttgc 136200
tgtgcagaag ctttttagtt tattattgtc ccatttgtct atttttgttt ttgttgcctg 136260
tgcttttggg atcttaacca taaactcttt gtctagatca acgttctgaa atgtttcccc 136320
tgtttccttc taacagtttc atagcttctg gtcttacatt taagtcttta atccatcttg 136380
agttgatttt tgtaaatagt gagagagtgg ggtctagttt catccttctg cagactgata 136440
tccagctttt ccagcacaat tttttgaagg tagttttctt tctctcatgt atgcttttgg 136500
tgcctttgtt gaaaatcagt tggctctaaa tatgtgggtt tatttctggg tcctctacat 136560
tggtctatgt atctgtgttt ttgccaacac tgtgctgttt tggttactct agccttgtaa 136620
tatattttca agtcaggtag tgtgatgcct ccagctttgt tctttttgct caggattgtt 136680
ttggctattt tggctctttt ttggttttat aatttttttt tctatttctg tgagaaatat 136740
ctttggagct ttcatgggaa tttcattgag tctgtagatt gctttgggta gtatggtcat 136800
tttaacaata ttaattcttc cagtctgtga gcatgaatat ctttccatgt gtttgtgtcc 136860
tcttcaattt ctttcatgtt tttcaggttt ccttatagag attgttcatc atcttggtta 136920
aatttattcc taggtgtttt attaattttt tgtagctact ttaaatggga ttgctttctt 136980
gatttttcag ccactttgtt cttgtgtaga tatgctacta atttctgtat gttggttttg 137040
aatcctttat tgtccttatt tatcagaact aagggttttt tttttgatgg aatctttagg 137100
tttttgagtt ttaattttaa tatctctaat catttaagat ggaaagtcgt tttttgaaag 137160
cacagatttt tagtgtttta ttctgtggat actcaatttg ctgagtgtgt tttatttttt 137220
tttttttgac aaagcttgaa ggagctgctc ctttgaagat actaaatata ggaaatgtca 137280
gtactccatt gatgtgtttg agtgaatcca caaattcaac agaaagaaat gtaatgtggg 137340
gaggatgtgg cacaaagatt ttctcctttt ctaatgattt caccattcag aaactcattg 137400
agacaagaac aagccaactg taagttattt tttatctgta caagtaattt gtcattatct 137460
ttatgtttat tccttataat cattaataat actgttgata attcataagg aagatctttt 137520
aaagtgcata atttatttct atcataaaat taaacattca ttataaaaaa ttttaaaaat 137580
ttcaaaaagc agaagggtat ttttaaaaag tcactcagcc taatatatag taatatatag 137640
cctaatatat agcctaaaca tacttttagg gataaaatat gtaaacccat tgtaatctta 137700
gtagtattta tcaatctaaa tttttaaata atttttatta tctgtgtttc aaattagaca 137760
tgaaattgga agacaatcaa ctctgcattt taccaaattc atagacttta catatgcaat 137820
ttgggtaatt tccattaagt attgattgta ggaaagatag acagcaagta ttcttgcttg 137880
tctcaagttg tttctagatt tgataattat acagatgtct actaacaacc aagttagtga 137940
taccagtttc aaacaagagt aaaataaaat attaatataa acctctttca agtttgtttt 138000
tttcagttgt attttaatca aatctttgcc attggtcctt atttatcaca ttcctcagtg 138060
ataagcagtg taggattgtg gataagagca taaaccatag ttcacgtatc gctttgccat 138120
ctattggttt tgtgaacttg ggcaataacc tttcacatct tcagtcatct cttacctgag 138180
gattgtaata ttctctatct caaagggata tttggaggag taaataagaa cattaatata 138240
tggaacttaa ttaacataac gaccagcacc tggtaagctg tcaataaaca ttagctattg 138300
ttgttattat tattattagc tttgagtcac aaatccctac cttagagaat atcctagttt 138360
cccaatatcc atctaattgc ccaagattgg cacttgggag taatctttga ctcctttgtt 138420
tttgctccct ttatccactt gaccctccta attgtcattc gaatctttgt acttctcact 138480
gttctcagtg ctgctaccat aggccagact gccatccatc atctgtggcc acattaacaa 138540
gagcatccag ttctcatcct ctgattacac tctcttccac ctattttcag cgttgcagac 138600
agagggacct ttctaaaatg tacatcaatc tgatgcaatt ctcctgctta aaacccttcg 138660
gtggcatccc attgtccttt atatgaagtc cagattcctt aagatagcct actgggccct 138720
tcataattca gtgcttgctt agctgtctag attcatattt tgcaaccttc ttgtcatctg 138780
tgctttaccc aaactgaaat tgactcagat ctctaagata acctgttacc tttcaccccc 138840
agcctttgaa tgtagtattc tctttacctg gataactatt atgcaccctg cctatttcag 138900
tccaaatgcc acttgctctg agtggcaggt taggtaactt tgtgcttcca ttgcatctat 138960
tgttttccat cacaatagcc attttatttt tataattgta ttttttaaag tagtttctta 139020
ataccactaa atctactagt tttcaacatt ggctgtgcaa ttagaaacca ctaggtagct 139080
gaaaataatg atacctgggc cctacctcag accaattaaa ttagatcagt taagcctggg 139140
atggggatca gacttgtttt tttttcaggt tctcaagtga ttctaaagta tattcgaggt 139200
taagatatac tgcagactgc aatgtattgt aagttcccat gaatgaggat ttttatttct 139260
gtgtgtacat atttgtttac tagtatgtgg ttaacattta gatcaactca ttttcattct 139320
gtaacaccca ctttttaaaa aatgaacgta aaaatgtatt ttattatttt tatctttcaa 139380
attttatttt agactccaag ggtacatgtg caggtttgtt aacaaaggta tagtgagtga 139440
tgctgaagtt tggaatacaa ctcaactcac aacccagcaa gtgagcatag tactcgatag 139500
gtagtttttc atcctttttc cccttcctgt aatttccact tttaacctaa ttatacaagc 139560
ctgaaaacct ttaaaaagaa agggcctcca gtttattttt ttatttcgta agacatttta 139620
tgggctcatg gatatcaatt aagtccttaa agttccatat aagatttgga gcacagatgc 139680
tttactagag agcatccata aagatcaagc tctcaaagat gttcatctcc caaaagagat 139740
tgggacttag ttgcataaac acttagagag aaatatttgc tctcttctga acaagtatct 139800
cctgtggcct tgatctctac cccacgaaac agacatcaca tcacgaatca gaggttgcct 139860
cattatcagt accctcatca tcatcaatac acaccgactg agaggcatat tgagtaatga 139920
aagatgactg cctttgaagc cagaagactg cacaacttgt ggagttctag gtctgcaaca 139980
tgtttttagt cctaggtcag caagcatgac gtcagtagtc atggaaccct gagcaaatta 140040
tttagcattt gtacatgttt ctttctacaa ttaaaaacat tgagatttgt catattttat 140100
gtttttttaa ttaagggtca aacaagatag cacacaaaag tattttataa aatacgaaaa 140160
ttccctgcaa aactttatcc taattggaac tattttctat taaatacagc aaacatccag 140220
gaaggcgtta cctaaaacat agtggctctc tgacaacaca tcatattttt atctcctttt 140280
ccagaataga aagaaaaggg ggagaaaaaa aaatcttcct gctctaggat gtactaatga 140340
ttgttgaatc attatggtat tttcatgtta tctatctgat ttaaatgcaa ttttgactat 140400
ttttacttat tcctggttgt tcattcatac tggagtgccg tctatccccc acttcataga 140460
ctgcttggta tatcagaggt gcttatctgt gcaactcttt actggacgag ggttatgtag 140520
aaaatacatc gtcctcatcc ttacgaaatt acactcataa tctagtgtga gggatgccct 140580
aataaagaca attttatatt taataaggtc tataatatga cagtgacacc agtggggaaa 140640
agggactggt tagtctattt tgataggtca gggaagaaat ccagaggagc tgacatttaa 140700
gttaatcctc aaaggccgag taggagtttg ccgtgttgat gtggcccatg gtagccaatc 140760
tgtttgtgaa atatgtacaa tgtcagatgc cttaggttga aagggaaata ttttaaggtg 140820
tttgtaattt ttctttatgt ttaaaagggg aaaatggcaa atattttact ttctgtttat 140880
gtttgaatga tgtggatttt tgtttcctat aatttgactg gctcaactgc aaagatatac 140940
cttgctttaa aatttgaaga cactgcaact aaattttttt tcaacatttt atattttata 141000
actctagatg taaaaggcta atgcttagtt ttctgagcat tcatgaaaca aagttttgca 141060
acgacattca aaagttacag atattataat atttccttca gaaatttaga tatagtataa 141120
aattctacaa agagctacat agaattgaaa ctaaaagtaa gtccaaagtc aacattggac 141180
ataatcttta ttttattatc aagagaaatt agtataaagt aaccaaaagt atgtaaaata 141240
ccaaagcatg ttatatattc aattcagaat tgttagggaa gaatatgaaa taattgcaat 141300
agtctagctt gtttagtttt caaaatagtg tttttacatg cattaagaac taaggttgta 141360
ttacacgtag aaattttaag aagaaaacaa atagtgatga ctttctattt ttttttctct 141420
gtaggttttc ttacgcagct ttcagtgatt ccaacatcgt aacagtggtg gtagacactg 141480
ttctctatat tgctaagaaa aatagccctg ttgtggaagt gtgggataag aaaactgaaa 141540
aactctgcga actaatagac tgtgtgcact ttttaaggtt aattcattgg cttttaagtt 141600
tatttccaaa agaattatct ttgcacttca tgtgtcgcag aggaaggatt tgtcttcctt 141660
tctgcctctg aatagagaat tttttaaaaa agcagaaaaa aaattgtaat gcttctcagc 141720
accagctctt caaatcagga acattttgtc ttgggaaaat aaaaaaatag gagcataata 141780
tgcatagttt tttcacggta ttataaagaa tgctctcgaa tgaaaatagt atattattga 141840
aaatgagcat actggagtct ctgctagctt tgatgtagtt gtgtcacagt gtcaaatata 141900
ctatttataa ttaaattgtg ggccccaaga ttatctgctc aaagaaaaag agtcacaaaa 141960
taatagacga atatgggggg aaacacaatg gactcagcaa ggcactaact aaggagttgg 142020
gatcaagacc tcagaatgag agcatagtgc ttagtctgat gcagccagtg agtgacaaat 142080
ccatagcaag cacattcttt ctgtgctggt gctaagaaac aggaccattt tcaagcttat 142140
ttgctagcta ctttatattt ttattttatt ttggttttac cttatagatc tatgatactc 142200
ttaagaacat ttgagattac acactgtatc tgtaaaagga gacttcaaag tttcctttct 142260
tagattcatc tgacagtttt tctctcgatt gtgagaaggg ctcacagttt atgttcagaa 142320
gaaccaacag gtctccttga taaaggattc cttacttcct ggagtaccaa aacgattagg 142380
attcttttat ttctggacac ttcattttgg tcgtgaatta gactattcac tggttctggg 142440
aaaaaatcca gtggtttgta tggatatctc ttacatgtga atgactataa ttttacgttc 142500
ctttgtaaca ctgagacatc atgtaaagct tttgagtcta actttttttt ctttatcctg 142560
ggcacatgca tgctattttt actgaattag atagctttgg tatttataaa aattgtatcc 142620
ctcttattca taatttcctg aaaatgaagg gctattgttg tctttgataa tttatgcttc 142680
aagtaaagaa atgtggctct ttggcattct gtgtttagca aaatttgctt tgtataattt 142740
taatgatgca taatgtgtgg tgtcatgttt tcataattta aaatgttatt tatgttttca 142800
tatataaata gcatttatgt cttagctggt ggtaaaatta ttaatgtata ctttatggtt 142860
ctagggaggt aatggtaaaa gtaaacaagg aatcaaaaca caaaatgtct tattctggga 142920
gagtgaaagc tctctgcctt cagaagaaca ctgctctttg gataggaact ggaggaggcc 142980
atattttact cctggatctt tcaactcgtc gagttatacg tataatttac aacttttgtg 143040
attcggtcag agtcatgatg acagcacagc taggcaagtt tctttccttt agatattttt 143100
catattctct aagtcttata aaatatgcct ttattttaca tttacttttt ctctgcactt 143160
tccagtgtca tttggatggt cttggaggtt cacacaatga aacataagac tggtgtaaat 143220
tgtgaatagg gtcattacag aaatggtggg agtaaatgct ctcagtccca taagagaagc 143280
agattactgc agctgaacac tcagtttggg tcttacttgc ttttttcctt tttacctaag 143340
gcaaaaatgg gaaatacata gtgttgaata tatttcactt tttgagcaaa gaaaataaag 143400
aaaatgttta ttttaatcat agtatagcct cccacgcttg ttaaagaatc tcatttagtt 143460
tttcattcta taacaaatct ttattcttgc agcaatacat gccgaaccac acaacctaca 143520
aatattgaca aatcatgttt tactgaaact ttgtcttttt ttgcttctat ttttctattt 143580
aaatatgatg aaatcgtgat agcacataaa atatattttc tgcataaata tatttgtgtc 143640
ttcctttgat aataatttga tttagaaaat aacaataaaa gcacatatac aaaagtttac 143700
aaaaacaaca ctatggggtt taattccgaa aaaaactaga atttatgtaa ctttagcaaa 143760
taattaatga atgttttgaa cgtggtgaag aaaatagatt cattacaagt atgtgtgaaa 143820
gaggaacatg tgtttctcta acaccttcac ctatttttca tttatagacg ttagagttgc 143880
acagaaggag ttagaattag atgctcttaa tgactgtgaa ctattaagat acatgtccac 143940
acaagcagaa cagtaggtat ctcaatgggt tgtctccgta gtcttattct accaaagttg 144000
ttgcattctc tagttgaatt gtatgtactt tgggacccgg atagcttgct tataactgaa 144060
gttatagtgg aatttcaatg ggttacagtt tgattttaaa ataaagatca atttgaacat 144120
agcctacaag gtgctgcgtg agctggcttc actgtacctc tcctgcctcc atcatctacc 144180
acattcctac cagatcttcc tcgtctagat gaacatccag ttcttcttaa ttactgtgct 144240
atattttgcc tcagagattt gcacatgctg tttatttctt tgcttaaagt aggtttttta 144300
tgcttagtta actcatacgc tttgaaatgt tagctcctgt gtcaaaacct ctgagaagca 144360
aacactgatt aggtcaaagt tcccactttg ggttcccata acagctttct tgcatagttg 144420
tgatcatagt catatatatt ttttttcatt aatactagtc tcttcactag aatataaaca 144480
ccaagcaggt tgggttagtg tgttttggtt taccccttta ttcccaggat ctagcctagg 144540
acttacatag aagacttttg atgcaaattt gttgaataaa ttagtgaatg atttgagaag 144600
aaaatatgat attttgacat cagtatatcc atccatctaa gtgtccatct aaatactcat 144660
atttgtacct taccatatcc aaagaacttt tcacacacat tacctcattt aacattgtaa 144720
ctttggggag ggtaatgtat aaatactaag cctattttat agaaaggtta agctgttttc 144780
tcagactcac ataattaaga gttgcagcaa ggagtggatc acagattctg ttactttttt 144840
ttaatgctgg cctttattca atataattta agggtcacct agaaaataga actgtgaatt 144900
cagttccaag gtatttgtgt cttagactat gaacaacttt aatttttttc agaccagctt 144960
aatatatagt tttaacggaa aacttccata ttttgttttt gtaaagggag ccttaaaaat 145020
gtcatgctgg tattgggcta taaccggaaa agtactgaag gtacacaaca gcagaaaggt 145080
aacatttaaa aggatactgt attccaaaca gtgcaatgac atgaatgata gtaacatatt 145140
atgtgtttta taaatttgta gaaaatatta catatggtat aatcaggaat tttaattggt 145200
agtttatagt ataaagaact taggcataaa ctttcaaaat tacaagtgat atgaagtgtt 145260
aaatatttat attttcagat gaagtagagg tgtcaatcac tagctcaacc ttaaactaaa 145320
tgtgaatatt ttttacaact tacctgtatc tacataatgt ttaattttca acagtgtttg 145380
aaaagcttta tttcttttag attatgaaat gttaatttat taaatgtcca cactcttctt 145440
gaaatttagt agtttctata atgtattata aaaattgtcc aagtacagtt ttttataaat 145500
aattatttag tgcattagtt atagctgtgt ttatatatac atttatctaa gtcaactaaa 145560
aatacataag ccaaactgaa ataaaataag aatgttttat ggtggatctt tgaaacttga 145620
tttcattttt ttctttttct agagatacaa tcttgcttga ctgtttggga catcaatctt 145680
ccacatgaag tgcaaaattt agaaaaacac attgaagtga gaaaagaatt agctgaaaaa 145740
atgagaggaa catctattga ataagagaga aacaggaatt gtctttggat aggaaaatta 145800
ttctcttgta aatatttatt taaaaatgtt cacatgaaaa gggtactcac attttttgaa 145860
atagctcatg tgtatatgaa ggaatgttat atttttaatt taaatatatg taaaaatact 145920
taccagtaaa catatatttt aaagaactat ttaaaacaca atgttgtatt tcttatgaat 145980
accagttact tttgtgcatt aattaatgaa aataaatctg tgaaatacct aatttaagta 146040
ctcatactaa aatttataag gccgataatt ttttgttttc ttgtctgtaa tgaagataaa 146100
ctttatttta aattctatgc ttaagacaag actattgctt gttgattttt ctagaaatcc 146160
gcaaggtaga atgaaaatat taagacagtt tcccgtgtaa tgtattccct cttagattgc 146220
tttgaaatgc actatcatat atgcttgcaa atattcaaat gaatttgcac taataaattc 146280
ctttgttggt atgtgaattc tctttgttgc tgttgcagac agtgcatgtt acacaacttc 146340
actcaatcca aaagaaaact ccattaaaag tactaatgaa aaaacatgac atactgtcaa 146400
agtcctcata tctaggatat gaggagagtt tctgtgtctt tctgtgtctt tcctagacat 146460
gatagagttg tctctatctt ttcaactcta tctttgagta tggataccct gaattttgta 146520
taattagtgt aaatacagtg ttcagtcctt caagtgatat ttttattttt ttattcatac 146580
cattagctac ttgttttcta atctgcttca tcctaatgct tatattcatc ttttccctaa 146640
atttgtgatg ctgcagatcc tacatcattc agatagaaac tttttttttt cagaattata 146700
gaattccaca gctcctacca agaccatgag gacaaatatc taacactttt cagttgctga 146760
aggagaaaag agctttagtt atgatggata aaaatatctg ccaccctagg cttccaaatt 146820
atacttaaat tgtttacata gcttaccaca gtaggagtat cagggccaaa tacctatgta 146880
ataatttgag gtcatttctg ctttaggaaa agtacttttg gtaaattctt tggccctgac 146940
cagtattcat tatttcagac aattccctgt gataggacaa ctagtctatt taatattctc 147000
agaacttaat ggcatttgac tatatgaaaa ctttaaattt atttatattc agggtgatca 147060
aattcttaaa catgaaagat tttctgtatt ttaacttgct acgtaattaa cgacaacaaa 147120
aaaaaataca gtagagctct ttgttccagt gttatctctt tcattgtcac tttgtatgta 147180
tttgcaaatt tttttaccaa agacaaacac aaaaatagaa tactgtattt acatggaata 147240
ataaaatttt taaaagcatg tttatgaatt tttaaacttt gtgatagtgt tttgcttttc 147300
acatacaggt ctgttatcca cctcaaagga aactttgtat attaatttgt atatggaaca 147360
ttccacgata agaaagtgca actaaagttt tttcttgaga acttacagaa tatttaaatt 147420
tacttttcta taatacgtat ggttgccagg atcccaggac aaaatctgat gggtatgaaa 147480
cattctattt tcaagttctc ttaaaaatgt tttgtgagta aatttgtttg ctcttgagta 147540
ctgaaacaaa atataagact ttagagcaaa tgatatatac aaaaaatagg cacagtcact 147600
tcaagtgttt tctgattaga agcctaaaat aacctgctaa ttatgatcaa aatacaaaca 147660
ttatcataac agaaaatatt cttttgggaa aattttgaat tcaaaaaagg gcgcctctct 147720
gactctaatt cactctatcg attatgtgtg aactatttta actaaaatgc aacttatttt 147780
tcatcaaggc agtgaaatat attgatgaaa catagcagaa atgttctaat attgagggga 147840
gataaaattc aaaaccgttg ggactttgct tctttatcca tcactttgag tagcttaaca 147900
cctaacctgg taaattgaat gtttttcatg gaggctcatc agcaattcag taaaatagta 147960
aactatgtca actcgggaga aactgacatc ctcgttctcc atgctagcca gttgctgatc 148020
cagggtatca ttgtttctaa taacaattca gaatctggct gcttaaaggc acctaggtac 148080
ttggttcttt ctaatttgtc aaggaatttg gagtgatcct atcaccctga tttcaagcaa 148140
gagacagtca cctgacccaa aggcctgctg tctgaacaca ctctgagtga gtgagcagag 148200
atgtggtggt tctctctatg tgctgccgcc acactgctct tgatttctac ccttacctgg 148260
gaagtctcta cttgatgtct gtctcaggct aagaaaaaga gaagagaaag ggaatgagta 148320
ttagcatctg gatcatgggg ctgcttcttg gcctctatga gaatccactg tttcacagca 148380
atcacggcct acaaaactgg atgttataga gtaaacaaga ggtatcattc tgacctgggc 148440
ttcgccacat ttacccactg aacactccca agagaaggtt gttaccattt atttatgaaa 148500
ataccaaact ccgatacata ctctattaga agtattatgg aaaagtagag catatgtcta 148560
cctggccaga gaatagagga tcctgatcac aaaaaaagta caaatattta aacagggact 148620
taggacaaac gggcattcaa caatttccag agtgaaataa cattctaggc agatgatgac 148680
acatgtgctg tcttaggaac ttgagcttat tttgaaagca tccctatcaa atacatgctg 148740
aaatttgtga caagttccca ttccttacag tacttacggg atacacttaa gtgactgaag 148800
atgcaagaga agtatatatt tgtgtatgga tatagcactt ttatcattaa ttgggagatt 148860
ataaagttaa tgagctgttc tttgcagagg gagtatttgt taggatgaaa tggggagaga 148920
tgtttcaaac accaagttta ttttataggt taagaaatcc tagaaggaat ccatgacttt 148980
atgtatatgt acaatatatg a 149001
<210> 4
<400> 4
000
<210> 5
<400> 5
000
<210> 6
<400> 6
000
<210> 7
<400> 7
000
<210> 8
<400> 8
000
<210> 9
<400> 9
000
<210> 10
<400> 10
000
<210> 11
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 11
ttccacactt gcggtcttta ga 22
<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 12
gcgggacctg gtaggtactg 20
<210> 13
<211> 15
<212> DNA
<213> Artificial Sequence
<220>
<223> Probe
<400> 13
atgagcagca atgat 15
<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 14
catcactcag gctgttaaga caaga 25
<210> 15
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 15
cagctgccag caaagatatc aa 22
<210> 16
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> Probe
<400> 16
ctttgccacc tccaccaccc ca 22
<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 17
gagcttcctc acgcagttca c 21
<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 18
tgctgggtct tgaaaatgaa ga 22
<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Probe
<400> 19
ttctaaatga atcaggagtc c 21
<210> 20
<211> 23
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 20
ccaggtacaa tgcaaagctt aat 23
<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 21
tcagtccaat cactgacaag tt 22
<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> Probe
<400> 22
ttgggaagtc cttggtgttc acca 24
<210> 23
<211> 19
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 23
ggcgagttat ccgcaccat 19
<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 24
ccaaaaccag catgacattc ttaa 24
<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence
<220>
<223> Probe
<400> 25
tgagagccat ggccacagca caa 23
<210> 26
<400> 26
000
<210> 27
<400> 27
000
<210> 28
<400> 28
000
<210> 29
<400> 29
000
<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 30
attaatttgc acagaagtga 20
<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 31
gacttctatt aatttgcaca 20
<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 32
accaaggact tcccaatcat 20
<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 33
gtgcatggca tcaaaaatta 20
<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 34
tccacatttc tgaatcccag 20
<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 35
tcttggtcat ctggatacat 20
<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 36
cactgaattt cttggtcatc 20
<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 37
cccagacact gaatttcttg 20
<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 38
gaggaatctc tttcagttta 20
<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 39
aaccttatga tgtctttggc 20
<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 40
gaaacatcca aatgtgtgcc 20
<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 41
tgcttctcat cagaaacatc 20
<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 42
tcctcggtgg cattcacaaa 20
<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 43
ccacttgggt tccacaaagt 20
<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 44
tacaaagcca cttgggttcc 20
<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 45
ggaaaccatt cttccatgag 20
<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 46
tttctaggca ggtcagccaa 20
<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 47
agcaggcgat ccaaggaacc 20
<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 48
caatgatggc agcattggga 20
<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 49
tgttggttat aaatgacatt 20
<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 50
tgaggatttt ctttcaaaca 20
<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 51
ttcaaaatgt caaagacctg 20
<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 52
aagtgacaga atcagtcatc 20
<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 53
tgagtttctg aatggtgaaa 20
<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 54
gctgccacta gccatggtgg 20
<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 55
tcctggacat tgttcagcct 20
<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 56
tggacagact tctattaatt 20
<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 57
agttccaagt tgtaactgac 20
<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 58
agagccaagg cttcatggca 20
<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 59
tttatgatgg ttttccgaag 20
<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 60
tgatctcgga tcttgaaatt 20
<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 61
atgaatactg gtcagggcca 20
<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 62
aaactgattt cagttcccca 20
<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 63
accttggtca tctggataca 20
<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 64
tgatctcgga tctatgaaat 20
<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 65
cccctggtgt tcaaaagcag 20
<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 66
tgtcaaagac ctgagaaagt 20
<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 67
cagcctgact atcaacttct 20
<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 68
ggacttccca atcatttcca 20
<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 69
gaaaatagtc tcagtgagga 20
<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 70
ttaagaaaat agtctcagtg 20
<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 71
ccatgatgct gttattctga 20
<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 72
cattcaacca tgatgctgtt 20
<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 73
gctctctttc tcacatacct 20
<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 74
ggactgctct ctttctcaca 20
<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 75
aatcctccaa ggcaaatgct 20
<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 76
aaaggaccaa gccaagaagg 20
<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 77
tggaaataaa ggaccaagcc 20
<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 78
acactgtcca tagaagagtc 20
<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 79
caaacacact gtccatagaa 20
<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 80
aaaatcttca gttccttcag 20
<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 81
agatgcagtt tctctactct 20
<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 82
cctcacgacc tgcaaaatcc 20
<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 83
gaattcctca cgacctgcaa 20
<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 84
tctcatcaga aacatccaaa 20
<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 85
ggtggcattc acaaagtggt 20
<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 86
gatcttgaaa ttaaggctct 20
<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 87
aatcttgacc aaaatcccat 20
<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 88
tcttcaacag agtttctcct 20
<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 89
gcccatttct tcaacagagt 20
<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 90
atgttcttca ccatcattaa 20
<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 91
tcaaattcca actcatcatt 20
<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 92
aaaatcttca cagccacttc 20
<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 93
attaaaaatc ttcacagcca 20
<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 94
gaggctggct ttgtcctgct 20
<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 95
ataatcatgg ctgagtggag 20
<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 96
gatggcagca ttgggataca 20
<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 97
ccatattctt taactggatc 20
<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 98
tctcaaccat aggccatggg 20
<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 99
ttcttgagga ttttctttca 20
<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 100
atgtcaaaga cctgggcaga 20
<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 101
gcaaccatgc attcaacaat 20
<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 102
tctactatca gcaacttcct 20
<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 103
aaacaagtga cagaatcagt 20
<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 104
gtgtttttct aaattttgca 20
<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 105
acttcaatgt gtttttctaa 20
<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 106
aaataacttg gaggctggaa 20
<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 107
gacaaaactg atttcagttc 20
<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 108
cacttaccaa gaaaattcat 20
<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 109
attatagaat ttaatcttaa 20
<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 110
acctccctag aaccataaag 20
<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 111
tccgctgctc agggaaccgg 20
<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 112
tggtgaacac caaggacttc 20
<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 113
gaatcaattg gtgaacacca 20
<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 114
ggaggagatc taaggtcttc 20
<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 115
aggtgatttt acctgaagtt 20
<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 116
atcattggct ggaaatgagt 20
<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 117
ggaatgcttt catagcttcc 20
<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 118
ttgtaacagg cttccagcca 20
<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 119
ccctatgagc tgggaaatgg 20
<210> 120
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 120
ccagggaagt gttgcttcct 20
<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 121
tccagctgca ctggtaatga 20
<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 122
caggatttcc aatgaacctg 20
<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 123
tctgcagtgt gtgaagcact 20
<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 124
tgatgcacca gcagcttaga 20
<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 125
tttgcttgat tggcatctgc 20
<210> 126
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 126
gttccaccaa tttgggactg 20
<210> 127
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 127
atcttgttca cgagatccac 20
<210> 128
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 128
ggcaaatgct attgttggcc 20
<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 129
gagtgcattc tggtgaagct 20
<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 130
aactcttcag agtttcacat 20
<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 131
gggagcatat ccctgatatt 20
<210> 132
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 132
ctttaggaca agcctcaaga 20
<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 133
agaccgcaag tgtggaagat 20
<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 134
tctaaagacc gcaagtgtgg 20
<210> 135
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 135
actgacatcc agagatgtca 20
<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 136
aggatcttag ttccaagttg 20
<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 137
gggaaaggat cttagttcca 20
<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 138
ccccatttca ttgggaaagg 20
<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 139
ccaagatctg atttcttggt 20
<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 140
agcaaggtac aatgctcgct 20
<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 141
catggcatca acttcagcct 20
<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 142
attgaagagc caaggcttca 20
<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 143
agcctttata ttgaagagcc 20
<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 144
agcgcgagcc tttatattga 20
<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 145
gaagaagcgc gagcctttat 20
<210> 146
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 146
gcagggaacc ctcgcttatt 20
<210> 147
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 147
tagcagtctg gaatcagctg 20
<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 148
cgtgaggaag ctcattttca 20
<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 149
gttttggaca accttccact 20
<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 150
tctggaattt ttctaggagc 20
<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 151
tgcttggaac cagcaaatat 20
<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 152
gtggtccaca acttggccca 20
<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 153
tggagcttgt tcaaattcca 20
<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 154
ggtggaggtg gcaaagcacc 20
<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 155
ccaaggaacc cttggaggct 20
<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 156
cctgctgaag caggcgatcc 20
<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 157
tttgtcctgc tgaagcaggc 20
<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 158
ggaggtatct caaaccatca 20
<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 159
gcaatctttg caatgatggc 20
<210> 160
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 160
cgtagtcagc aatctttgca 20
<210> 161
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 161
tgatgtgtag caaccatgca 20
<210> 162
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 162
tgttgtgatg tgtagcaacc 20
<210> 163
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 163
agcccagcca aatgcttgca 20
<210> 164
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 164
ggtgtgccca cagcccagcc 20
<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 165
tcagaagtgt atccttcagt 20
<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 166
gcagtgttct tctgaaggca 20
<210> 167
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 167
tgtcatcatg actctgaccg 20
<210> 168
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 168
aggactttga cagtatgtca 20
<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 169
tccttcagca actgaaaagt 20
<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 170
tggaagccta gggtggcaga 20
<210> 171
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 171
agttgtccta tcacagggaa 20
<210> 172
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 172
atcagattcc cctgaggtac 20
<210> 173
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 173
cagtctgaat cagattcccc 20
<210> 174
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 174
gttcagctgc agtaatctgc 20
<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 175
actgagtgtt cagctgcagt 20
<210> 176
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 176
cccaaactga gtgttcagct 20
<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 177
acttactggt gaacaccaag 20
<210> 178
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 178
atgagctggg aaactttcaa 20
<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 179
tctggcatgc ctaaatgcac 20
<210> 180
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 180
ttgtactgac cttggtcatc 20
<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 181
tcttcagagt ctgaaaagac 20
<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 182
aagcgcgagc ctggagggaa 20
<210> 183
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 183
tggaggtatc tgccagaaaa 20
<210> 184
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 184
atcacctacc tggtgtgccc 20
<210> 185
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 185
tgggactgct ctctttctca 20
<210> 186
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 186
atttgggact gctctctttc 20
<210> 187
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 187
ttcacgagat ccactattca 20
<210> 188
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 188
gtcacctttc ccaatgctta 20
<210> 189
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 189
ggccacatcc agggccagcc 20
<210> 190
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 190
tcaacttttc ctatacaaaa 20
<210> 191
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 191
ataaaggacc aagccaagaa 20
<210> 192
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 192
gaaataaagg accaagccaa 20
<210> 193
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 193
tctggaaata aaggaccaag 20
<210> 194
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 194
ttatctggaa ataaaggacc 20
<210> 195
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 195
aattagaagt cttatctgga 20
<210> 196
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 196
tcaccattct tgctagtgta 20
<210> 197
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 197
cctgaggctg ttccttcttc 20
<210> 198
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 198
catcaaattt agacagcaca 20
<210> 199
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 199
aacacactgt ccatagaaga 20
<210> 200
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 200
agcaaacaca ctgtccatag 20
<210> 201
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 201
ttgagcaaac acactgtcca 20
<210> 202
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 202
agaaatgagc cttcacttcc 20
<210> 203
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 203
ggtaaaattc tcctacacta 20
<210> 204
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 204
atgtctttgc aaatttggtg 20
<210> 205
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 205
ttcagtaaat cttcatgatc 20
<210> 206
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 206
atgacctgag tgaatcatct 20
<210> 207
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 207
gagaagaaat gctgtctgaa 20
<210> 208
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 208
tgctgaaagg tctagtgatg 20
<210> 209
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 209
tatacagcat ttctggctta 20
<210> 210
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 210
ttctggtgaa gctccagctt 20
<210> 211
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 211
tcttcagagt ttcacatagc 20
<210> 212
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 212
aaggaaatga tgtaaattta 20
<210> 213
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 213
agagacatca agattagcaa 20
<210> 214
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 214
ttcactgtag gatctaaaac 20
<210> 215
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 215
gacagctggt tatatgacag 20
<210> 216
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 216
gctccagttt ctctaccaca 20
<210> 217
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 217
agttccttca gtctcaaggg 20
<210> 218
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 218
ctgataggga tgaaatgtgg 20
<210> 219
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 219
ggcactgaaa ctctccactt 20
<210> 220
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 220
atagaaggag gcaagaaagg 20
<210> 221
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 221
ctggaataca ggaaaatttg 20
<210> 222
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 222
gctcatatct aaagaccgca 20
<210> 223
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 223
gatttccagt gtgcgggacc 20
<210> 224
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 224
tgctgatctg attatggcta 20
<210> 225
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 225
ctctactcta gaccataaat 20
<210> 226
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 226
ctcaggagga atctctttca 20
<210> 227
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 227
ttgtaactga catccagaga 20
<210> 228
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 228
tgcttaattt ccccatttca 20
<210> 229
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 229
atcaaagtta agatgcagtt 20
<210> 230
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 230
tatgatgtct ttggctttac 20
<210> 231
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 231
ccttatgatg tctttggctt 20
<210> 232
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 232
gaaaccttat gatgtctttg 20
<210> 233
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 233
agaaacctta tgatgtcttt 20
<210> 234
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 234
gaagaaacct tatgatgtct 20
<210> 235
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 235
gtttcattcg gttataaggc 20
<210> 236
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 236
caataaggtg gttttaccac 20
<210> 237
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 237
ctttgcattc caagatctga 20
<210> 238
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 238
ttatttggat aggccagtct 20
<210> 239
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 239
aaaatcccac acatttagga 20
<210> 240
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 240
aaggtacaat gctcgctgcg 20
<210> 241
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 241
atggcatcaa cttcagcctg 20
<210> 242
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 242
gggaagaaga agcgcgagcc 20
<210> 243
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 243
gcttctcatc agaaacatcc 20
<210> 244
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 244
attcaggagt tccttggtga 20
<210> 245
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 245
gcattcacaa agtggtaatc 20
<210> 246
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 246
tgatggtttt ccgaagtttt 20
<210> 247
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 247
aacaacaagc tgatctcgga 20
<210> 248
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 248
atgatttttt caagttctac 20
<210> 249
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 249
caattacggg aaattcaatt 20
<210> 250
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 250
ctgcagctga ttttctctca 20
<210> 251
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 251
tcatttagaa agtgaactgc 20
<210> 252
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 252
tcacttaact gcagtgctgg 20
<210> 253
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 253
tgggttccac aaagtacaag 20
<210> 254
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 254
acttgggttc cacaaagtac 20
<210> 255
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 255
agccacttgg gttccacaaa 20
<210> 256
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 256
caaagccact tgggttccac 20
<210> 257
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 257
tgctctcttt ctcacatacc 20
<210> 258
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 258
ctgctctctt tctcacatac 20
<210> 259
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 259
actgctctct ttctcacata 20
<210> 260
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 260
tcaccgcccg cagccagcgc 20
<210> 261
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 261
ctgctcaggg aaccggcagg 20
<210> 262
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 262
tggcacctgc ttccaacccg 20
<210> 263
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 263
acttcttcag agtttcctcg 20
<210> 264
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 264
tgactatcaa cttcttcaga 20
<210> 265
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 265
gcctgactat caacttcttc 20
<210> 266
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 266
ttcagcctga ctatcaactt 20
<210> 267
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 267
ttgttcagcc tgactatcaa 20
<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 268
gtttctatct gttttccttc 20
<210> 269
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 269
cttgaaataa cttggaggcg 20
<210> 270
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 270
ataggagtcc aagacgatca 20
<210> 271
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 271
ttgcacagaa gtgaccaacc 20
<210> 272
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 272
gtcccattaa gctttgcatt 20
<210> 273
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 273
attggtgaac accaaggact 20
<210> 274
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 274
caagtttaca ctggcattat 20
<210> 275
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 275
cctgaagtta ggaggagatc 20
<210> 276
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 276
catgaaaata tcactttctt 20
<210> 277
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 277
tggcatcaaa aattaacatg 20
<210> 278
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 278
gcatggcatc aaaaattaac 20
<210> 279
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 279
gagtgcatgg catcaaaaat 20
<210> 280
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 280
aatgagtgca tggcatcaaa 20
<210> 281
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 281
acttcatcat tggctggaaa 20
<210> 282
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 282
ctctctcaaa cagcacatgt 20
<210> 283
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 283
ataatctttg ttctcaacaa 20
<210> 284
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 284
atttcctctt catctttaaa 20
<210> 285
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 285
aaggaatcgc tagggaatgt 20
<210> 286
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 286
ataacacctg acattgccac 20
<210> 287
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 287
gctttcatag cttccaccac 20
<210> 288
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 288
aatgctttca tagcttccac 20
<210> 289
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 289
agggaatgct ttcatagctt 20
<210> 290
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 290
catagggaat gctttcatag 20
<210> 291
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 291
ctttcactca tagggaatgc 20
<210> 292
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 292
ctaatgtaag cctatggagc 20
<210> 293
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 293
ccacaaactc atggacttcg 20
<210> 294
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 294
gatctgcaat gctgcattct 20
<210> 295
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 295
catcatcatt ctcttgattc 20
<210> 296
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 296
tttgtaacag gcttccagcc 20
<210> 297
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 297
agcatgcggc ctcctgcacg 20
<210> 298
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 298
ctcatgtaaa ctgttttggt 20
<210> 299
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 299
acttccctat gagctgggaa 20
<210> 300
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 300
ggaaaacttc ctttgatgaa 20
<210> 301
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 301
ttgataacag tatttttctg 20
<210> 302
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 302
tatatgcttc tgcattaact 20
<210> 303
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 303
tgatttagca ttttacagcc 20
<210> 304
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 304
ctgctgccat tatatccagg 20
<210> 305
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 305
ggtaatgatg tctcatgacg 20
<210> 306
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 306
caggcactat aaaatgtaaa 20
<210> 307
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 307
cttatgatga aattctgtat 20
<210> 308
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 308
tttgtgaata tcattcttga 20
<210> 309
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 309
aatcccagga tttccaatga 20
<210> 310
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 310
atttctgaat cccaggattt 20
<210> 311
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 311
cacatttctg aatcccagga 20
<210> 312
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 312
aatccacatt tctgaatccc 20
<210> 313
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 313
tttaatccac atttctgaat 20
<210> 314
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 314
tcaggaaaat gtacaataga 20
<210> 315
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 315
gaagcactga atccatagca 20
<210> 316
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 316
tgaacacatt cttctttgta 20
<210> 317
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 317
tataagctgg aaaccagaat 20
<210> 318
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 318
tctgaaatcc tttagtctgt 20
<210> 319
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 319
cagcttagaa aaagatgctg 20
<210> 320
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 320
gacatttgat ggaatattac 20
<210> 321
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 321
agaggtttag aaactgttga 20
<210> 322
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 322
ttttaagtaa tcatccatag 20
<210> 323
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 323
atgatgctgt tattctgatc 20
<210> 324
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 324
ttgcttgatt ggcatctgct 20
<210> 325
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 325
ctttctcaca tacctgacaa 20
<210> 326
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 326
tctctttctc acatacctga 20
<210> 327
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 327
ctgtgccatg attttacaaa 20
<210> 328
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 328
cccttagggt gttttggaca 20
<210> 329
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 329
cctttttttt gaaagaaatt 20
<210> 330
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 330
tctaggagct taaaatactg 20
<210> 331
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 331
aaccagcaaa tattcttctc 20
<210> 332
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 332
ttcagagttc tcacaatggg 20
<210> 333
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 333
ccaaaatccc attggaaaat 20
<210> 334
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 334
agcatgtaag gtgaaatctc 20
<210> 335
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 335
gccaatacat tctgtttggg 20
<210> 336
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 336
cagacaataa gcttcaggag 20
<210> 337
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 337
atttttaaga aactctctgg 20
<210> 338
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 338
cttggcccaa aagaatacag 20
<210> 339
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 339
gcaacccagg aaaccattct 20
<210> 340
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 340
tttcttcaac agagtttctc 20
<210> 341
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 341
ccatttcttc aacagagttt 20
<210> 342
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 342
atgcccattt cttcaacaga 20
<210> 343
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 343
ataatgccca tttcttcaac 20
<210> 344
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 344
gattttttga tgttcttcac 20
<210> 345
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 345
taagagatct ccttcctctg 20
<210> 346
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 346
atctgagata ttggaatggt 20
<210> 347
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 347
acataatatt tctaggcagg 20
<210> 348
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 348
gagaaactct ggagcttgtt 20
<210> 349
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 349
tcataggctg ctcggtaaac 20
<210> 350
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 350
gtgatgtatg tttattaaaa 20
<210> 351
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 351
gtggaggtgg caaagcacca 20
<210> 352
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 352
ctccatcacc aacatccggg 20
<210> 353
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 353
ttgtcctgct gaagcaggcg 20
<210> 354
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 354
cgtggagtgc aatcctgtgc 20
<210> 355
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 355
gtatataatc atggctgagt 20
<210> 356
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 356
ggatacagtg tgaaaagcag 20
<210> 357
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 357
gagcaatgcc gtagtcagca 20
<210> 358
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 358
tactgagcaa tgccgtagtc 20
<210> 359
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 359
cagtactgag caatgccgta 20
<210> 360
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 360
agcagtactg agcaatgccg 20
<210> 361
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 361
acagcagtac tgagcaatgc 20
<210> 362
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 362
tctacagcag tactgagcaa 20
<210> 363
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 363
ctggtgtgcc ctctgatgtt 20
<210> 364
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 364
gttataaatg acatttcctc 20
<210> 365
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 365
atgtcataga gtagtaaacc 20
<210> 366
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 366
atttggaaac ttcaaaccct 20
<210> 367
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 367
actggatcag gtaattttcc 20
<210> 368
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 368
ttaatttctc aaccataggc 20
<210> 369
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 369
agaagtaggc ctttcttgag 20
<210> 370
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 370
agacagacta attcagctga 20
<210> 371
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 371
ccatgcattc aacaattacg 20
<210> 372
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 372
gcccagccaa atgcttgcat 20
<210> 373
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 373
tttaagtcaa gaaatgagag 20
<210> 374
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 374
atattctact atcagcaact 20
<210> 375
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 375
ccagctttcc ttttcaacag 20
<210> 376
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 376
gtattgatga ccaggagagt 20
<210> 377
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 377
aatcagtcat cttttctagg 20
<210> 378
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 378
tttgctttgc ttggaaaagg 20
<210> 379
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 379
gctaacttgc catcagcggt 20
<210> 380
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 380
aaggagcagc tcctttaagc 20
<210> 381
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 381
acacatcaat ggagtactga 20
<210> 382
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 382
ccccacatta catttctttc 20
<210> 383
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 383
tggtgaaatc attagaaaag 20
<210> 384
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 384
cataagaaaa cagttggctt 20
<210> 385
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 385
agtgtctacc accactgtta 20
<210> 386
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 386
cacacttcca caacagggct 20
<210> 387
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 387
gcacgcagtc tattagtcca 20
<210> 388
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 388
gttttgattc cttgttttct 20
<210> 389
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 389
ctgaaggcag agggttttca 20
<210> 390
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 390
aaaatatggc ctcctccagt 20
<210> 391
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 391
caaaagttgt aaattacacg 20
<210> 392
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 392
taaggcttcc tagctgtgct 20
<210> 393
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 393
ttcagtattt ttccggttgt 20
<210> 394
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 394
caaacggtca agcaagattg 20
<210> 395
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 395
caatgtgttt ttctaaattt 20
<210> 396
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 396
tcttactcaa cagatgttcg 20
<210> 397
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 397
gaggagagaa taattttcct 20
<210> 398
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 398
gagtaccctt tccatgtgaa 20
<210> 399
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 399
aaaataataa cattccttca 20
<210> 400
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 400
aaaatacaca tttactggta 20
<210> 401
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 401
ctggtattta taagaaatat 20
<210> 402
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 402
attaggtact tcacagattt 20
<210> 403
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 403
aacaaaaaat tatcggcctt 20
<210> 404
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 404
cttaagcaca gaatttaaaa 20
<210> 405
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 405
ataccgtgca gatttctaga 20
<210> 406
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 406
aagaaggaat acattacatg 20
<210> 407
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 407
tttgaatatt tacaagcata 20
<210> 408
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 408
attagtgcaa attcatttga 20
<210> 409
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 409
actttattag tgcaaattca 20
<210> 410
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 410
aaaggacttt attagtgcaa 20
<210> 411
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 411
ccaacaaagg actttattag 20
<210> 412
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 412
acataccaac aaaggacttt 20
<210> 413
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 413
aagagaattc acataccaac 20
<210> 414
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 414
aattgagtga agttgtgtaa 20
<210> 415
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 415
atgtcatgtt ttttcattag 20
<210> 416
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 416
aaagagagtt tctgtgtctt 20
<210> 417
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 417
acaactctat tatgtctagg 20
<210> 418
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 418
tatacaaaat tcagggtatc 20
<210> 419
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 419
tagtggtatg aataaaaaaa 20
<210> 420
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 420
agatgaatat aagcattaga 20
<210> 421
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 421
tatctgaatg atgtaggatc 20
<210> 422
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 422
gtaggagctg tggaattcta 20
<210> 423
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 423
cttcagcaac tgaaaagtgt 20
<210> 424
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 424
ctagggtggc agatattttt 20
<210> 425
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 425
tattgtggta agctatgtaa 20
<210> 426
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 426
aaatgacctc aaattattac 20
<210> 427
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 427
ggtcagggcc aaagaattta 20
<210> 428
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 428
actagttgtc ctatcacagg 20
<210> 429
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 429
gttttcacat agtaaaatgc 20
<210> 430
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 430
tcatctttaa gaatttgatt 20
<210> 431
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 431
ataacaagtt aaagcatagc 20
<210> 432
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 432
ctggaacaaa gagctctatt 20
<210> 433
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 433
ctttggtaaa aaaaattgca 20
<210> 434
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 434
attattccat ttaaatatgg 20
<210> 435
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 435
cctttattat tccatttaaa 20
<210> 436
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 436
aaaaaccttt attattccat 20
<210> 437
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 437
cctctttcag tttattgtga 20
<210> 438
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 438
atagttgaca ggaatttata 20
<210> 439
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 439
gtttagtgga agtattaagg 20
<210> 440
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 440
tatatgataa catcacacat 20
<210> 441
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 441
ttccatagaa cactctttat 20
<210> 442
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 442
aggaaattat gctgtgttac 20
<210> 443
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 443
agaaaaatgg tttatttaag 20
<210> 444
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 444
acactgacca tacacaagct 20
<210> 445
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 445
gcctagctgt gctgtcatca 20
<210> 446
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 446
taccagtctt atgtttcact 20
<210> 447
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 447
atttcccatt tttgccttag 20
<210> 448
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 448
tgtattgctg caagaaaaaa 20
<210> 449
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 449
acgcaaatat atttatgcag 20
<210> 450
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 450
atgttcaaaa cattcattat 20
<210> 451
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 451
taatagttta cagtcattaa 20
<210> 452
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 452
tataacttca gttataagca 20
<210> 453
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 453
agacaagcaa gatctggtag 20
<210> 454
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 454
acaggagcta acatttcaaa 20
<210> 455
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 455
aaccgtcttg gagtttatat 20
<210> 456
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 456
tatactgata ctatgtcaaa 20
<210> 457
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 457
cagtatttat acattaccct 20
<210> 458
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 458
ttttctaggt gacccttcaa 20
<210> 459
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 459
cctttctgct tttgtgtacc 20
<210> 460
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 460
aagttcttta cactataaac 20
<210> 461
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 461
gacattatgt agatatagat 20
<210> 462
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 462
attattattt ataaaaaact 20
<210> 463
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 463
tgtatctcta gaaaaagaaa 20
<210> 464
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 464
aatcacagtc agaggttcct 20
<210> 465
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 465
cccttttcca aactattcat 20
<210> 466
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 466
gtgacaaagt tgcattttat 20
<210> 467
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 467
tctacaagag tttgctagtg 20
<210> 468
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 468
aagtgctgaa ctctacaaga 20
<210> 469
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 469
ctctcacttc gctatgacag 20
<210> 470
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 470
aaccgtcaat tttctaaaga 20
<210> 471
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 471
ctattcaatt aaaagcttat 20
<210> 472
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 472
ctcaaggaaa aaacctgttt 20
<210> 473
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 473
aaaggcggca atttctgata 20
<210> 474
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 474
tatacttgac atggtcaaaa 20
<210> 475
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 475
ctccaattca ttctattata 20
<210> 476
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 476
aacatagctg gtaaaattac 20
<210> 477
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 477
aaacattcaa tgaatagaag 20
<210> 478
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 478
acggaagaaa tttttcttca 20
<210> 479
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 479
ccagtcttcg attctctgcc 20
<210> 480
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 480
ttggctttac attattggaa 20
<210> 481
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 481
gtggccgttg ctcacgcctg 20
<210> 482
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 482
tcttagacat gttgatatat 20
<210> 483
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 483
tcttagcagg actgatgagg 20
<210> 484
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 484
caaatcaatt cattaccaag 20
<210> 485
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 485
gctctagatc tttataaatg 20
<210> 486
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 486
tacttttccc agtataagcc 20
<210> 487
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 487
ccttatgcct tgttaagcaa 20
<210> 488
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 488
gaaattagac tggtaaactg 20
<210> 489
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 489
atcccattct gggaactgca 20
<210> 490
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 490
ttgtattcct tgcaaaatgt 20
<210> 491
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 491
ttagttgcaa gatagaacat 20
<210> 492
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 492
atggtctagt ttccacagta 20
<210> 493
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 493
agtaagttcc atttggagtc 20
<210> 494
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 494
gggaaattct agagaaaact 20
<210> 495
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 495
tgtgaagcag cccttcctaa 20
<210> 496
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 496
acttcaggtc acaccttcat 20
<210> 497
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 497
cacatcaaat taatttcttc 20
<210> 498
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 498
aaacagaata tgaaccatta 20
<210> 499
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 499
acaaaacaga atatgaacca 20
<210> 500
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 500
aaaacaaaac agaatatgaa 20
<210> 501
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 501
tacaaaacaa aacagaatat 20
<210> 502
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 502
tgtggataag aaaacattgt 20
<210> 503
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 503
tcttgacttt tgcattatga 20
<210> 504
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 504
aaatgttaac tgttcttttt 20
<210> 505
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 505
tcagctatga cctgtttcct 20
<210> 506
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 506
aaatcagcta tgacctgttt 20
<210> 507
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 507
gtaaaaaata ctatgctgtt 20
<210> 508
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 508
caaacattaa caattttgct 20
<210> 509
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 509
acctctaata aattgtgctg 20
<210> 510
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 510
gcatggaata gtaaaggccc 20
<210> 511
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 511
attgctaggt agagaactta 20
<210> 512
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 512
tctaataaat gaccaagtta 20
<210> 513
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 513
gaactttata tatagttatc 20
<210> 514
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 514
cttgtgggaa agcatgaatc 20
<210> 515
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 515
tccaacagtt aacgatcatt 20
<210> 516
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 516
gatataatca tgatactaga 20
<210> 517
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 517
cagttttagt catataacaa 20
<210> 518
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 518
tacagtttta gtcatataac 20
<210> 519
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 519
atatgtatat ttatatacat 20
<210> 520
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 520
taaatatgta tatttatata 20
<210> 521
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 521
gtataaatat gtatatttat 20
<210> 522
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 522
tgtgtataaa tatgtatatt 20
<210> 523
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 523
atctgtgtat aaatatgtat 20
<210> 524
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 524
tacatctgtg tataaatatg 20
<210> 525
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 525
atatacatct gtgtataaat 20
<210> 526
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 526
tttatataca tctgtgtata 20
<210> 527
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 527
atatttatat acatctgtgt 20
<210> 528
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 528
tgtatattta tatacatctg 20
<210> 529
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 529
ttgtatattt atatacatct 20
<210> 530
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 530
tatttgtata tttatataca 20
<210> 531
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 531
ttatatttgt atatttatat 20
<210> 532
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 532
tatttatatt tgtatattta 20
<210> 533
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 533
atatatttat atttgtatat 20
<210> 534
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 534
tgtatatatt tatatttgta 20
<210> 535
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 535
aaatgtatat atttatattt 20
<210> 536
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 536
tataaatgta tatatttata 20
<210> 537
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 537
atatataaat gtatatattt 20
<210> 538
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 538
tttatatata aatgtatata 20
<210> 539
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 539
atatttatat ataaatgtat 20
<210> 540
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 540
tgtatattta tatataaatg 20
<210> 541
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 541
atatgtatat ttatatataa 20
<210> 542
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 542
ccatgtttag aagaaatact 20
<210> 543
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 543
attacatagt ttggcaaaac 20
<210> 544
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 544
actgcagaaa tatgtacctt 20
<210> 545
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 545
caccccagga agaagtccca 20
<210> 546
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 546
gttaaattac ctttaacata 20
<210> 547
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 547
tccttgaaag tatcctctac 20
<210> 548
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 548
ccatcctatc cagataaata 20
<210> 549
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 549
aggtgtgctt taggagaagc 20
<210> 550
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 550
ttattaaggc agaactccaa 20
<210> 551
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 551
catcccaagt gcctacagac 20
<210> 552
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 552
actttgaaag tggcagaaaa 20
<210> 553
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 553
ttacagttat tttcacaaag 20
<210> 554
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 554
caaacattat aatttctata 20
<210> 555
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 555
tataagcatg tggaggtatc 20
<210> 556
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 556
tgctatgtgc tatacaatta 20
<210> 557
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 557
cttacaagtc tgcagttacg 20
<210> 558
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 558
tgcccagaat ctacagaatc 20
<210> 559
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 559
tccagggctg caactgtaca 20
<210> 560
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 560
gttctgtgga cactgagata 20
<210> 561
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 561
gctttgcttg ttaactgaaa 20
<210> 562
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 562
tttctctcag gtatttaagc 20
<210> 563
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 563
gacttcttat aaggtatttt 20
<210> 564
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 564
ggctggtacc caaacttgtc 20
<210> 565
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 565
caaggctggt acccaaactt 20
<210> 566
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 566
acaatcccag caggtaggtg 20
<210> 567
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 567
atccttctga cctacgatgg 20
<210> 568
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 568
ctttgaactc ataagataga 20
<210> 569
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 569
gcttattgaa agactgatct 20
<210> 570
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 570
gaaggaagag aacaggtatg 20
<210> 571
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 571
cgcctctctc acgctgcctg 20
<210> 572
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 572
tgcaaacaat tttaataaac 20
<210> 573
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 573
tgactaccat ggacctccaa 20
<210> 574
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 574
ccttcactgg gtctcacttg 20
<210> 575
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 575
actaagctga aactatgaat 20
<210> 576
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 576
ctgattgatt gttaactaac 20
<210> 577
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 577
ttataagtaa gtagatttga 20
<210> 578
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 578
agattgttgc acaaatattt 20
<210> 579
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 579
tactattcaa atggatataa 20
<210> 580
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 580
gaactatgct aaaaacacta 20
<210> 581
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 581
ttttgtgtga gtaggctgtg 20
<210> 582
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 582
tatattcaac ataccctgtt 20
<210> 583
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 583
tacaacataa attcttgcca 20
<210> 584
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 584
aatcttactg tcaatatagt 20
<210> 585
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 585
ttaaaaggaa gtaaccatgt 20
<210> 586
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 586
tggtatccct cctaagtgct 20
<210> 587
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 587
ctctcttggc tcccgactgc 20
<210> 588
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 588
taccttattt ggaactctgc 20
<210> 589
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 589
ttacttatat gtaatttgtt 20
<210> 590
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 590
catcctgtaa acctttttta 20
<210> 591
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 591
aaagattaaa ttaagctgca 20
<210> 592
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 592
acattaggaa tctcacctca 20
<210> 593
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 593
ctgaatataa atattatcta 20
<210> 594
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 594
atgtatagct agaatgagga 20
<210> 595
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 595
agatgcaact caagaaaact 20
<210> 596
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 596
tatttataaa gcacctatct 20
<210> 597
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 597
aaattatatc aaattgatat 20
<210> 598
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 598
ttttatagag gctgaggaga 20
<210> 599
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 599
gccaaacttt aaagatgcag 20
<210> 600
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 600
cgaataaact cagctagctg 20
<210> 601
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 601
gacagttatt atatatcatg 20
<210> 602
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 602
aaatttattc ttaatctccc 20
<210> 603
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 603
aaaacaagtg aatgctacag 20
<210> 604
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 604
ctcttatgat gctgagtatc 20
<210> 605
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 605
atgttttaat gaaagattgg 20
<210> 606
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 606
ttaactatag atatattggg 20
<210> 607
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 607
ggcaaaatga ataaacagta 20
<210> 608
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 608
ttgaatattt acctgacaaa 20
<210> 609
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 609
agtgttacac aactttggcc 20
<210> 610
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 610
gagggcttta aagaaagata 20
<210> 611
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 611
tgtagtacag ttgtatcagg 20
<210> 612
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 612
taaacctaat acataatcct 20
<210> 613
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 613
tctttaaacc taatacataa 20
<210> 614
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 614
attagaacct actggacctt 20
<210> 615
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 615
ttttctctaa gatatgccat 20
<210> 616
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 616
gctcatagca aaattaaaag 20
<210> 617
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 617
tttcatttaa tgtagcactg 20
<210> 618
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 618
agcaactgag acttggattt 20
<210> 619
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 619
acatttagtg tgaacaaatg 20
<210> 620
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 620
tgctagtgag tgcatcataa 20
<210> 621
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 621
tggatgggta cttttctcta 20
<210> 622
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 622
aggtagagag agagtaacac 20
<210> 623
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 623
atttagagct aggtagagag 20
<210> 624
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 624
tgagaaataa agtgctatag 20
<210> 625
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 625
tgaatggtag tatatgtgag 20
<210> 626
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 626
acattgtgag gtcaaaaaag 20
<210> 627
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 627
tccctctcca atgggcccac 20
<210> 628
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 628
ttccagagta atatgttatg 20
<210> 629
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 629
gataaacccc aagaaggcaa 20
<210> 630
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 630
tacattatgt attagctcta 20
<210> 631
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 631
gtgttcaagt catagaaatg 20
<210> 632
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 632
aaccaattag tataacattt 20
<210> 633
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 633
ctcatttttt gccctctcaa 20
<210> 634
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 634
taattttcaa agcgcatgaa 20
<210> 635
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 635
atgttaattt tcaaagcgca 20
<210> 636
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 636
gaagaaactt ttttggataa 20
<210> 637
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 637
aataaatttg gcaacttata 20
<210> 638
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 638
gagaaagtaa cacaaacaat 20
<210> 639
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 639
caaatcctca attacaactt 20
<210> 640
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 640
accaacaaat cctcaattac 20
<210> 641
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 641
ggagatagag atcaacattt 20
<210> 642
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 642
aattaagggc catatacata 20
<210> 643
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 643
acccaattat gaggataaaa 20
<210> 644
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 644
tcatttattg gagaagagga 20
<210> 645
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 645
aaaccaaact atggagttta 20
<210> 646
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 646
aagtcctgtc ctcaaagagt 20
<210> 647
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 647
aacaagtcct gtcctcaaag 20
<210> 648
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 648
aacaaacaaa gtgccatcta 20
<210> 649
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 649
attatagagg cttattaacc 20
<210> 650
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 650
tagagttgaa agcttccttc 20
<210> 651
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 651
ccatctgagg aacttaagtc 20
<210> 652
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 652
gtcaaactct tcagagtctg 20
<210> 653
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 653
tatatagtat atatataata 20
<210> 654
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 654
ttatatatag tatatatata 20
<210> 655
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 655
gtattatata tagtatatat 20
<210> 656
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 656
taagtattat atatagtata 20
<210> 657
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 657
taataagtat tatatatagt 20
<210> 658
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 658
atataataag tattatatat 20
<210> 659
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 659
tatatataat aagtattata 20
<210> 660
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 660
tttcatagtt ttatagcatt 20
<210> 661
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 661
gtcttatagt tgggaacgaa 20
<210> 662
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 662
actatcattt taacctctga 20
<210> 663
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 663
acagtaggcc aagtaactat 20
<210> 664
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 664
aagtgatgat aataatttgc 20
<210> 665
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 665
tggccaatat tcaggagggt 20
<210> 666
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 666
gctttgctta ctagtgagtg 20
<210> 667
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 667
gtttgaagga atagctgaca 20
<210> 668
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 668
agtgtttgaa ggaatagctg 20
<210> 669
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 669
catagtgttt gaaggaatag 20
<210> 670
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 670
agccatagtg tttgaaggaa 20
<210> 671
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 671
aaaagccata gtgtttgaag 20
<210> 672
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 672
ctaaaaagcc atagtgtttg 20
<210> 673
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 673
attctaaaaa gccatagtgt 20
<210> 674
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 674
gcagcatcat gcaagcagca 20
<210> 675
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 675
attgcagcat catgcaagca 20
<210> 676
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 676
tggcggaatg cagaaattta 20
<210> 677
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 677
gtgggaagga agaaatgtgc 20
<210> 678
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 678
agcatattaa tgccaaatat 20
<210> 679
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 679
aaaggcaaat gacacacagc 20
<210> 680
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 680
attagtctgg ctaagaagaa 20
<210> 681
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 681
acagagctga ggtctgcaac 20
<210> 682
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 682
aagctcagga gttcagaaaa 20
<210> 683
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 683
ggtttctgga tattagaaca 20
<210> 684
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 684
ttgtcagcaa ccgatcaaag 20
<210> 685
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 685
caatttggag tctacaatga 20
<210> 686
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 686
aaatgtaacc ttacgacatt 20
<210> 687
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 687
taatgctaac agcaacaagg 20
<210> 688
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 688
tcacctttac ccttgtgatt 20
<210> 689
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 689
caggccaaat aggactctat 20
<210> 690
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 690
agtcatatta gtttctaatt 20
<210> 691
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 691
ctgctctgct aatgggctgg 20
<210> 692
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 692
ttcatgtatc tcttaaccca 20
<210> 693
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 693
acttccatat ttacctgcaa 20
<210> 694
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 694
tgcactaaac tcatttgaca 20
<210> 695
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 695
gcatcatctc agggagccat 20
<210> 696
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 696
cagcatatct cagcatacct 20
<210> 697
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 697
caaacagtga aacatggaat 20
<210> 698
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 698
ttcaattgac taattcagta 20
<210> 699
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 699
gctgattgca atgtttcaat 20
<210> 700
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 700
aaatcacatt atccatgaca 20
<210> 701
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 701
aatagctgtc agacaagttg 20
<210> 702
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 702
ttagagcttc tgcaccatga 20
<210> 703
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 703
ttccacctga ttaattgaat 20
<210> 704
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 704
attttttaaa gagtttgtgc 20
<210> 705
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 705
tataaactca taggccctgg 20
<210> 706
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 706
gtttaaggaa tacttaaaca 20
<210> 707
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 707
tgccctgaga atgaaataac 20
<210> 708
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 708
tttgatggat tctacttgca 20
<210> 709
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 709
ctcaaagtaa ctactgcatt 20
<210> 710
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 710
tctaaaaatc taataagtct 20
<210> 711
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 711
tactccaagg ttttatgagc 20
<210> 712
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 712
aagagataat tacagtccct 20
<210> 713
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 713
ctaaacgcaa aactttctga 20
<210> 714
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 714
tagaatacaa gattttattg 20
<210> 715
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 715
tgagcaccta aacatgctac 20
<210> 716
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 716
acagcatcgc aggtcttgta 20
<210> 717
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 717
aatgcatttc atagttgtcc 20
<210> 718
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 718
ttctctattt gagaatcgcc 20
<210> 719
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 719
aaatttcaag ttggagtagg 20
<210> 720
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 720
gtcatatagt ggcccctaaa 20
<210> 721
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 721
cactggtatg cccttccaac 20
<210> 722
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 722
gaatttctta cttgtcttaa 20
<210> 723
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 723
gctacataaa ataaatcacc 20
<210> 724
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 724
agagtctgaa gtatctagaa 20
<210> 725
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 725
tgaagcctgg aaccagttta 20
<210> 726
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 726
cctaaagcca attagcacaa 20
<210> 727
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 727
agtgtagcca ctaagaattt 20
<210> 728
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 728
cttatacact aattggctct 20
<210> 729
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 729
tttcttccac cattccctta 20
<210> 730
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 730
ctcactaatt gcaaagaaaa 20
<210> 731
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 731
caaagcttca gactgtgatc 20
<210> 732
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 732
tcagagaggc ccgccatggg 20
<210> 733
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 733
ttcacatggc tgaagtcttg 20
<210> 734
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 734
atctactgaa ttctggttag 20
<210> 735
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 735
gcacacagtg tagtcatact 20
<210> 736
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 736
aacccaagat tccccctggt 20
<210> 737
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 737
tggagaagta agctaacagt 20
<210> 738
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 738
taactgaaaa ttcaagcctg 20
<210> 739
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 739
cttaaggaaa atgagctctc 20
<210> 740
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 740
tataatatct agctttccct 20
<210> 741
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 741
cagagggaga aaaacactga 20
<210> 742
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 742
cccttgaggg tgtcacaatc 20
<210> 743
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 743
atctttgtat ctctgctccc 20
<210> 744
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 744
ttgaaataat aagtaaagat 20
<210> 745
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 745
ataagacatg cctctttaag 20
<210> 746
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 746
agtacatatt atttaactgc 20
<210> 747
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 747
actgttggtt ttggctcaca 20
<210> 748
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 748
tctggagact gacccacgca 20
<210> 749
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 749
gctgagtgga ggtatctgcc 20
<210> 750
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 750
atatggttta ggagagacta 20
<210> 751
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 751
atacttaact catggataga 20
<210> 752
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 752
aaaagtgcaa ttgccatagg 20
<210> 753
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 753
ccggtaacat tttatttacc 20
<210> 754
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 754
tcaatgtatt gttgccaaat 20
<210> 755
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 755
atgagctacc cacacagtca 20
<210> 756
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 756
ttggaaggat ggagacatcg 20
<210> 757
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 757
tgatatggca tgatgtctac 20
<210> 758
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 758
agatgatatg ctatgacata 20
<210> 759
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 759
tgtcctgtct cataacatct 20
<210> 760
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 760
agaatattta tgcactaaac 20
<210> 761
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 761
gttctaacag caatttcctt 20
<210> 762
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 762
atccttatgt cctcacagat 20
<210> 763
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 763
tatttcctct caatgtttat 20
<210> 764
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 764
ttaaaaaaag gaatgggata 20
<210> 765
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 765
caacctgaaa aaattagtct 20
<210> 766
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 766
ataaatgagt tgatcagtgg 20
<210> 767
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 767
tattcctgga tgagaaaaat 20
<210> 768
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 768
cctaagactg gttaaaatat 20
<210> 769
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 769
ataaggaaag ttgttctggg 20
<210> 770
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 770
atgcaataac aattatgcac 20
<210> 771
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 771
ggagttgata tttcaggtac 20
<210> 772
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 772
ttttcagagg atctactgtg 20
<210> 773
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 773
taaatgtgag gaaatatttg 20
<210> 774
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 774
catatgtata gtccgtgaat 20
<210> 775
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 775
tcactgagga atgtgataaa 20
<210> 776
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 776
tttattgaca gcttaccagg 20
<210> 777
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 777
agcaaaaaac aaaggagtca 20
<210> 778
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 778
gagaacagtg agaagtacaa 20
<210> 779
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 779
tagagatctg agtcaatttc 20
<210> 780
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 780
gctactgtga aggaaaacat 20
<210> 781
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 781
atccaaatgt taaccacata 20
<210> 782
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 782
acaggagata cttgttcaga 20
<210> 783
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 783
tagaaaatag ttccaattag 20
<210> 784
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 784
ccttaaaata tttccctttc 20
<210> 785
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 785
aaagataatt cttttgggaa 20
<210> 786
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 786
gtacaaatat gagtatttag 20
<210> 787
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 787
gagctcagct caccgcccgc 20
<210> 788
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 788
gccggccaca gctccccggg 20
<210> 789
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 789
ccgccctccc agcatgaacg 20
<210> 790
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 790
tccaacccgc cgccctccca 20
<210> 791
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 791
tagccatggt ggcacctgct 20
<210> 792
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 792
agctgccact agccatggtg 20
<210> 793
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 793
acccctgaca gctgccacta 20
<210> 794
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 794
cctcttcgca cccctgacag 20
<210> 795
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 795
tatctgtttt ccttcctgga 20
<210> 796
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 796
ctatctgttt tccttcctgg 20
<210> 797
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 797
tctatctgtt ttccttcctg 20
<210> 798
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 798
ttctatctgt tttccttcct 20
<210> 799
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 799
tttctatctg ttttccttcc 20
<210> 800
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 800
cgtttctatc tgttttcctt 20
<210> 801
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 801
ctccaggatt tggaccagcg 20
<210> 802
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 802
cagcagatcc tccaggattt 20
<210> 803
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 803
cgtgaacacc agcagatcct 20
<210> 804
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 804
tatttttgcc ttgaaataac 20
<210> 805
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 805
gcacatggat atttttgcct 20
<210> 806
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 806
tcaacagagg cacatggata 20
<210> 807
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 807
gactctcata taggagtcca 20
<210> 808
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 808
cacactcgcg actctcatat 20
<210> 809
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 809
cacctgctgc acactcgcga 20
<210> 810
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 810
tgaccaaccc acctgctgca 20
<210> 811
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 811
tctattaatt tgcacagaag 20
<210> 812
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 812
ggacagactt ctattaattt 20
<210> 813
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 813
attgtacctg gacagacttc 20
<210> 814
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 814
atcatttcca acatcctggg 20
<210> 815
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 815
gacttcccaa tcatttccaa 20
<210> 816
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 816
taagaatcaa ttggtgaaca 20
<210> 817
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 817
ttagcatttt aagaatcaat 20
<210> 818
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 818
attatgaact gttagcattt 20
<210> 819
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 819
aatcactgac aagtttacac 20
<210> 820
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 820
cttcagtcca atcactgaca 20
<210> 821
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 821
atctaaggtc ttcagtccaa 20
<210> 822
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 822
agttaggagg agatctaagg 20
<210> 823
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 823
aagttaggag gagatctaag 20
<210> 824
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 824
gaagttagga ggagatctaa 20
<210> 825
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 825
tgaagttagg aggagatcta 20
<210> 826
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 826
ctgaagttag gaggagatct 20
<210> 827
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 827
acctgaagtt aggaggagat 20
<210> 828
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 828
tacctgaagt taggaggaga 20
<210> 829
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 829
ttacctgaag ttaggaggag 20
<210> 830
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 830
tttacctgaa gttaggagga 20
<210> 831
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 831
ttttacctga agttaggagg 20
<210> 832
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 832
gtgattttac ctgaagttag 20
<210> 833
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 833
atcagcaagg tgattttacc 20
<210> 834
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 834
tcatccaata tcagcaaggt 20
<210> 835
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 835
tcactttctt catccaatat 20
<210> 836
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 836
atggcatcaa aaattaacat 20
<210> 837
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 837
catggcatca aaaattaaca 20
<210> 838
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 838
tgcatggcat caaaaattaa 20
<210> 839
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 839
agtgcatggc atcaaaaatt 20
<210> 840
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 840
tgagtgcatg gcatcaaaaa 20
<210> 841
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 841
atgagtgcat ggcatcaaaa 20
<210> 842
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 842
aaatgagtgc atggcatcaa 20
<210> 843
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 843
gaaatgagtg catggcatca 20
<210> 844
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 844
ttggctggaa atgagtgcat 20
<210> 845
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 845
agtttctgga cttcatcatt 20
<210> 846
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 846
ttgcatccaa gtttctggac 20
<210> 847
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 847
tgtaaagctt tgcatccaag 20
<210> 848
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 848
cctctgagac tctctcaaac 20
<210> 849
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 849
tcagttgctc ctctgagact 20
<210> 850
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 850
caaattcagt cagttgctcc 20
<210> 851
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 851
caatatcata taatctttgt 20
<210> 852
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 852
cgcacttaac aatatcatat 20
<210> 853
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 853
atttgttaac gcacttaaca 20
<210> 854
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 854
atctttaaaa tttgttaacg 20
<210> 855
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 855
tgaagcacaa tttcctcttc 20
<210> 856
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 856
tgcagcacat gaagcacaat 20
<210> 857
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 857
tgtaaacaat gcagcacatg 20
<210> 858
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 858
cattattgca aggaatcgct 20
<210> 859
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 859
ggacttccac attattgcaa 20
<210> 860
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 860
cactcatgag gacttccaca 20
<210> 861
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 861
cacaatatta taacacctga 20
<210> 862
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 862
tgctttcata gcttccacca 20
<210> 863
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 863
atgctttcat agcttccacc 20
<210> 864
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 864
gaatgctttc atagcttcca 20
<210> 865
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 865
gggaatgctt tcatagcttc 20
<210> 866
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 866
tagggaatgc tttcatagct 20
<210> 867
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 867
atagggaatg ctttcatagc 20
<210> 868
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 868
tcatagggaa tgctttcata 20
<210> 869
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 869
ctcataggga atgctttcat 20
<210> 870
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 870
actcataggg aatgctttca 20
<210> 871
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 871
cactcatagg gaatgctttc 20
<210> 872
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 872
tcactcatag ggaatgcttt 20
<210> 873
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 873
ttcactcata gggaatgctt 20
<210> 874
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 874
tttcactcat agggaatgct 20
<210> 875
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 875
tctttcactc atagggaatg 20
<210> 876
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 876
ttctttcact catagggaat 20
<210> 877
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 877
attctttcac tcatagggaa 20
<210> 878
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 878
aattctttca ctcataggga 20
<210> 879
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 879
gaattctttc actcataggg 20
<210> 880
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 880
tcttgaattc tttcactcat 20
<210> 881
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 881
gcaactcact tcttgaattc 20
<210> 882
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 882
gagcaaacag caactcactt 20
<210> 883
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 883
aaaaattacc taatgtaagc 20
<210> 884
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 884
ggatattgaa aaaattacct 20
<210> 885
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 885
ttaataccag gatattgaaa 20
<210> 886
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 886
accacaaact catggacttc 20
<210> 887
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 887
caccacaaac tcatggactt 20
<210> 888
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 888
tcaccacaaa ctcatggact 20
<210> 889
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 889
ttcaccacaa actcatggac 20
<210> 890
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 890
tttcaccaca aactcatgga 20
<210> 891
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 891
acagctttca ccacaaactc 20
<210> 892
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 892
tactgctgca cagctttcac 20
<210> 893
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 893
ttctctgggt actgctgcac 20
<210> 894
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 894
agggccaaac agctgagcgc 20
<210> 895
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 895
tcagtgagga gggccaaaca 20
<210> 896
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 896
ctaaatcttg atttaagaaa 20
<210> 897
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 897
tcttttcctc taaatcttga 20
<210> 898
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 898
cttgattctc attcttttcc 20
<210> 899
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 899
cttccccctc atcatcattc 20
<210> 900
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 900
atttatcttc ttccccctca 20
<210> 901
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 901
gccaaaacaa tttatcttct 20
<210> 902
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 902
cgttaatgct ttgtaacagg 20
<210> 903
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 903
cttgttcttt ctatgccacg 20
<210> 904
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 904
ttagtgccca gcatgcggcc 20
<210> 905
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 905
ggagattatt tagtgcccag 20
<210> 906
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 906
ggtacataag gagattattt 20
<210> 907
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 907
tccaatcttc tcatgtaaac 20
<210> 908
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 908
atcttcatct ccaatcttct 20
<210> 909
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 909
gaaatggcca tcttcatctc 20
<210> 910
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 910
gagagcatca cttccctatg 20
<210> 911
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 911
atcagcatgg agagcatcac 20
<210> 912
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 912
gaagaatgca tcagcatgga 20
<210> 913
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 913
cagatgcctg gaaaacttcc 20
<210> 914
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 914
atgcattcgc agatgcctgg 20
<210> 915
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 915
gagttgacaa tgcattcgca 20
<210> 916
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 916
tgttctaaga gagttgacaa 20
<210> 917
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 917
gtattccttt tgataacagt 20
<210> 918
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 918
cattcaggtg tattcctttt 20
<210> 919
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 919
actccaaaac attcaggtgt 20
<210> 920
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 920
aggagaatgt atatgcttct 20
<210> 921
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 921
agccacttca ggagaatgta 20
<210> 922
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 922
gccactttca gccacttcag 20
<210> 923
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 923
tcaaaaagat gatttagcat 20
<210> 924
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 924
ttgcttcctt caaaaagatg 20
<210> 925
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 925
cagggaagtg ttgcttcctt 20
<210> 926
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 926
ataactgtta gtattttggg 20
<210> 927
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 927
agctgcactg gtaatgatgt 20
<210> 928
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 928
tgtaaaatag ctcgaagcgc 20
<210> 929
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 929
ctggcatgcc aggcactata 20
<210> 930
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 930
tggattcttc tggcatgcca 20
<210> 931
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 931
tatcctccct ggattcttct 20
<210> 932
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 932
ccatatttag cttatgatga 20
<210> 933
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 933
gttttttaac catatttagc 20
<210> 934
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 934
tgaaacactg ttttttaacc 20
<210> 935
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 935
taggaccagt ttgtgaatat 20
<210> 936
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 936
caaagctgct aggaccagtt 20
<210> 937
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 937
gaacctgttc aaagctgcta 20
<210> 938
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 938
atttccaatg aacctgttca 20
<210> 939
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 939
ttctgaatcc caggatttcc 20
<210> 940
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 940
tttctgaatc ccaggatttc 20
<210> 941
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 941
catttctgaa tcccaggatt 20
<210> 942
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 942
acatttctga atcccaggat 20
<210> 943
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 943
ccacatttct gaatcccagg 20
<210> 944
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 944
atccacattt ctgaatccca 20
<210> 945
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 945
taatccacat ttctgaatcc 20
<210> 946
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 946
agaaattact tttaatccac 20
<210> 947
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 947
tacaatagaa gaaattactt 20
<210> 948
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 948
tctaatgcat caggaaaatg 20
<210> 949
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 949
gataacatct ctaatgcatc 20
<210> 950
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 950
ccttccaggg ataacatctc 20
<210> 951
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 951
tccatagcac cttccaggga 20
<210> 952
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 952
actgaatcca tagcaccttc 20
<210> 953
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 953
cactgaatcc atagcacctt 20
<210> 954
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 954
gcactgaatc catagcacct 20
<210> 955
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 955
agcactgaat ccatagcacc 20
<210> 956
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 956
aagcactgaa tccatagcac 20
<210> 957
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 957
tgaagcactg aatccatagc 20
<210> 958
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 958
gtgaagcact gaatccatag 20
<210> 959
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 959
tgtgaagcac tgaatccata 20
<210> 960
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 960
gtgtgaagca ctgaatccat 20
<210> 961
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 961
tgtgtgaagc actgaatcca 20
<210> 962
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 962
gcagtgtgtg aagcactgaa 20
<210> 963
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 963
gatacatctg cagtgtgtga 20
<210> 964
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 964
ggtcatctgg atacatctgc 20
<210> 965
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 965
gaatttcttg gtcatctgga 20
<210> 966
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 966
agacttaaac ccagacactg 20
<210> 967
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 967
tatcctataa gacttaaacc 20
<210> 968
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 968
gtaatcaagt atcctataag 20
<210> 969
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 969
cagttcctat gaacacattc 20
<210> 970
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 970
gcagatgtcc agttcctatg 20
<210> 971
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 971
tttttgccag cagatgtcca 20
<210> 972
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 972
aaaccagaat ttttgccagc 20
<210> 973
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 973
ttaaatcggt ataagctgga 20
<210> 974
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 974
gcaacatcct taaatcggta 20
<210> 975
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 975
tgtatttcag caacatcctt 20
<210> 976
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 976
ctaagattgt ctgaaatcct 20
<210> 977
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 977
tgaggattgc taagattgtc 20
<210> 978
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 978
ctgacaattt gaggattgct 20
<210> 979
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 979
atgcaccagc agcttagaaa 20
<210> 980
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 980
aaatgaatga tgcaccagca 20
<210> 981
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 981
tactaagtca aatgaatgat 20
<210> 982
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 982
gatattggaa gacatttgat 20
<210> 983
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 983
ttgttccatg atattggaag 20
<210> 984
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 984
tttagaaact gttgatcctt 20
<210> 985
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 985
gtttagaaac tgttgatcct 20
<210> 986
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 986
ggtttagaaa ctgttgatcc 20
<210> 987
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 987
aggtttagaa actgttgatc 20
<210> 988
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 988
gaggtttaga aactgttgat 20
<210> 989
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 989
cagaggttta gaaactgttg 20
<210> 990
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 990
acagaggttt agaaactgtt 20
<210> 991
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 991
aacagaggtt tagaaactgt 20
<210> 992
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 992
caacagaggt ttagaaactg 20
<210> 993
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 993
gcaacagagg tttagaaact 20
<210> 994
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 994
acttgcaaca gaggtttaga 20
<210> 995
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 995
ttgcaaaaca cttgcaacag 20
<210> 996
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 996
tagctacttt tgcaaaacac 20
<210> 997
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 997
catcacattt tttaagtaat 20
<210> 998
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 998
tctctctagc atcacatttt 20
<210> 999
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 999
atcacacgct ctctctagca 20
<210> 1000
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1000
agaagcaagc attcaaccat 20
<210> 1001
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1001
gctcccaata gaagcaagca 20
<210> 1002
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1002
tgattggcat ctgctcccaa 20
<210> 1003
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1003
ttgattggca tctgctccca 20
<210> 1004
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1004
cttgattggc atctgctccc 20
<210> 1005
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1005
gcttgattgg catctgctcc 20
<210> 1006
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1006
tgcttgattg gcatctgctc 20
<210> 1007
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1007
ctttgcttga ttggcatctg 20
<210> 1008
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1008
cctttgcttg attggcatct 20
<210> 1009
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1009
tcctttgctt gattggcatc 20
<210> 1010
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1010
ctcctttgct tgattggcat 20
<210> 1011
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1011
atccctcctt tgcttgattg 20
<210> 1012
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1012
ttaaagaaga tccctccttt 20
<210> 1013
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1013
cctgacaaat taaagaagat 20
<210> 1014
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1014
tctttctcac atacctgaca 20
<210> 1015
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1015
ctctttctca catacctgac 20
<210> 1016
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1016
ctctctttct cacatacctg 20
<210> 1017
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1017
gactgctctc tttctcacat 20
<210> 1018
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1018
gggactgctc tctttctcac 20
<210> 1019
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1019
ttgggactgc tctctttctc 20
<210> 1020
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1020
tttgggactg ctctctttct 20
<210> 1021
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1021
aatttgggac tgctctcttt 20
<210> 1022
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1022
caatttggga ctgctctctt 20
<210> 1023
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1023
tcagtaagag ttccaccaat 20
<210> 1024
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1024
tacatcttgt tcacgagatc 20
<210> 1025
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1025
gatctggctg tcacctttcc 20
<210> 1026
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1026
caagctgatg atctggctgt 20
<210> 1027
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1027
ccttaagagc aagctgatga 20
<210> 1028
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1028
ggccagcctc cttaagagca 20
<210> 1029
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1029
gctattgttg gccacatcca 20
<210> 1030
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1030
aaggcaaatg ctattgttgg 20
<210> 1031
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1031
aaatcctcca aggcaaatgc 20
<210> 1032
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1032
caagaaggtt caacttttcc 20
<210> 1033
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1033
gtttccttaa attagaagtc 20
<210> 1034
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1034
atatttgttt gtttccttaa 20
<210> 1035
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1035
gtagatgcta tatttgtttg 20
<210> 1036
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1036
gatatctgat caccattctt 20
<210> 1037
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1037
ttttcatctg atatctgatc 20
<210> 1038
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1038
ccacagcact tttcatctga 20
<210> 1039
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1039
ttccttcttc cacagcactt 20
<210> 1040
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1040
ccatcgctgc ctgaggctgt 20
<210> 1041
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1041
gaaaaatttc catcgctgcc 20
<210> 1042
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1042
acatcttcag aaaaatttcc 20
<210> 1043
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1043
aggtccattc atcaaattta 20
<210> 1044
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1044
caggaataaa ggtccattca 20
<210> 1045
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1045
tagaagagtc aggaataaag 20
<210> 1046
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1046
acacactgtc catagaagag 20
<210> 1047
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1047
aaacacactg tccatagaag 20
<210> 1048
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1048
gcaaacacac tgtccataga 20
<210> 1049
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1049
gagcaaacac actgtccata 20
<210> 1050
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1050
tgagcaaaca cactgtccat 20
<210> 1051
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1051
tttgagcaaa cacactgtcc 20
<210> 1052
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1052
ctttgagcaa acacactgtc 20
<210> 1053
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1053
gtcatcactt tgagcaaaca 20
<210> 1054
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1054
actatccagg tcatcacttt 20
<210> 1055
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1055
acttccttca ctatccaggt 20
<210> 1056
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1056
tttttcacaa gaaatgagcc 20
<210> 1057
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1057
ttagatttct ttttcacaag 20
<210> 1058
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1058
ctaattgaat tagatttctt 20
<210> 1059
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1059
cggcatctcg gtaaaattct 20
<210> 1060
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1060
gctgtaatac ggcatctcgg 20
<210> 1061
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1061
ggaattggaa tgtctttgca 20
<210> 1062
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1062
gggccccaag gaattggaat 20
<210> 1063
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1063
atcaaaaatg ggccccaagg 20
<210> 1064
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1064
ctttttcgct tcagtaaatc 20
<210> 1065
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1065
ataatatttt tctttttcgc 20
<210> 1066
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1066
catctgaaga taatattttt 20
<210> 1067
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1067
gaagttttga tgacctgagt 20
<210> 1068
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1068
tatgggattg aagttttgat 20
<210> 1069
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1069
aatgcctcat atgggattga 20
<210> 1070
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1070
tgctgtctga atgcctcata 20
<210> 1071
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1071
cagaagccag agaagaaatg 20
<210> 1072
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1072
attctctctc agaagccaga 20
<210> 1073
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1073
atgtaatata ttctctctca 20
<210> 1074
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1074
tagttcattt gctgaaaggt 20
<210> 1075
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1075
aatatctctt agttcatttg 20
<210> 1076
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1076
tagggcatca atatctctta 20
<210> 1077
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1077
tttctggctt agggcatcaa 20
<210> 1078
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1078
atgaacactt atacagcatt 20
<210> 1079
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1079
atgctccaaa tgaacactta 20
<210> 1080
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1080
cttttcaaga tgctccaaat 20
<210> 1081
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1081
gtgagtgcat tctggtgaag 20
<210> 1082
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1082
tagctgttgt ggaaagctcg 20
<210> 1083
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1083
gtgtcaaact cttcagagtt 20
<210> 1084
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1084
tgtgtcaaac tcttcagagt 20
<210> 1085
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1085
atgtgtcaaa ctcttcagag 20
<210> 1086
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1086
aatgtgtcaa actcttcaga 20
<210> 1087
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1087
agtccaaatg tgtcaaactc 20
<210> 1088
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1088
tactgtgcaa gtccaaatgt 20
<210> 1089
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1089
taaatttatt actgtgcaag 20
<210> 1090
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1090
acaaataaga aggaaatgat 20
<210> 1091
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1091
tcattttcaa caaataagaa 20
<210> 1092
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1092
caatacaact cattttcaac 20
<210> 1093
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1093
gtcatttcga gagacatcaa 20
<210> 1094
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1094
gggtccaatg tcatttcgag 20
<210> 1095
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1095
aaccactgag ggtccaatgt 20
<210> 1096
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1096
gttggacatt tcactgtagg 20
<210> 1097
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1097
tgtttcagag ttggacattt 20
<210> 1098
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1098
aggttaaact gtttcagagt 20
<210> 1099
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1099
ttatatgaca ggttaaactg 20
<210> 1100
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1100
ggtacaaaag acagctggtt 20
<210> 1101
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1101
aggttctcag gtacaaaaga 20
<210> 1102
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1102
acatcagtga ggttctcagg 20
<210> 1103
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1103
aaatgagctg ctccagtttc 20
<210> 1104
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1104
ttccttctaa aatgagctgc 20
<210> 1105
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1105
ctgatatttt atttccttct 20
<210> 1106
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1106
agcatatccc tgatatttta 20
<210> 1107
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1107
cagttccttc agtctcaagg 20
<210> 1108
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1108
tcagttcctt cagtctcaag 20
<210> 1109
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1109
ttcagttcct tcagtctcaa 20
<210> 1110
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1110
cttcagttcc ttcagtctca 20
<210> 1111
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1111
tcttcagttc cttcagtctc 20
<210> 1112
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1112
ttaaaatctt cagttccttc 20
<210> 1113
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1113
tactaaggtt taaaatcttc 20
<210> 1114
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1114
tgtggttctt actaaggttt 20
<210> 1115
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1115
gaaagttctc tgatagggat 20
<210> 1116
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1116
aagcctcaag aaagttctct 20
<210> 1117
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1117
attcattctg gcactgaaac 20
<210> 1118
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1118
agcaagaaaa ttcattctgg 20
<210> 1119
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1119
aggcatagca gcaagaaaat 20
<210> 1120
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1120
aggattgtca tagaaggagg 20
<210> 1121
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1121
gataatttta ggattgtcat 20
<210> 1122
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1122
tttgttctga gataatttta 20
<210> 1123
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1123
aaattgcttc tggaatacag 20
<210> 1124
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1124
gaagatttaa aattgcttct 20
<210> 1125
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1125
gcaagtgtgg aagatttaaa 20
<210> 1126
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1126
tatctaaaga ccgcaagtgt 20
<210> 1127
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1127
atatctaaag accgcaagtg 20
<210> 1128
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1128
catatctaaa gaccgcaagt 20
<210> 1129
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1129
tcatatctaa agaccgcaag 20
<210> 1130
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1130
ctcatatcta aagaccgcaa 20
<210> 1131
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1131
tgctcatatc taaagaccgc 20
<210> 1132
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1132
ctgctcatat ctaaagaccg 20
<210> 1133
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1133
gctgctcata tctaaagacc 20
<210> 1134
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1134
tgctgctcat atctaaagac 20
<210> 1135
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1135
ttgctgctca tatctaaaga 20
<210> 1136
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1136
atcattgctg ctcatatcta 20
<210> 1137
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1137
gtactgaata tcattgctgc 20
<210> 1138
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1138
acctggtagg tactgaatat 20
<210> 1139
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1139
aagttcaaag atttccagtg 20
<210> 1140
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1140
agttccctta agttcaaaga 20
<210> 1141
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1141
ctaaataaga gttcccttaa 20
<210> 1142
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1142
agtccaagat gctgatctga 20
<210> 1143
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1143
tttcactcaa gtccaagatg 20
<210> 1144
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1144
aatatgcttt ttcactcaag 20
<210> 1145
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1145
atgcagtttc tctactctag 20
<210> 1146
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1146
gtgagaaaga tgcagtttct 20
<210> 1147
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1147
cagtttattg tgagaaagat 20
<210> 1148
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1148
aatctctttc agtttattgt 20
<210> 1149
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1149
acagccaatc tcaggaggaa 20
<210> 1150
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1150
attttcaaga cagccaatct 20
<210> 1151
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1151
agatgtcaga ttttcaagac 20
<210> 1152
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1152
aaggatctta gttccaagtt 20
<210> 1153
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1153
tcattgggaa aggatcttag 20
<210> 1154
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1154
cccatatttt gcttaatttc 20
<210> 1155
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1155
aaggaagatc ccatattttg 20
<210> 1156
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1156
gttcatccaa aggaagatcc 20
<210> 1157
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1157
tatgtttaaa atcaaagtta 20
<210> 1158
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1158
tacatcctat atgtttaaaa 20
<210> 1159
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1159
ttatgatgtc tttggcttta 20
<210> 1160
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1160
cttatgatgt ctttggcttt 20
<210> 1161
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1161
accttatgat gtctttggct 20
<210> 1162
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1162
aaaccttatg atgtctttgg 20
<210> 1163
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1163
aagaaacctt atgatgtctt 20
<210> 1164
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1164
atcgctgttg aagaaacctt 20
<210> 1165
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1165
ccttttttaa tcgctgttga 20
<210> 1166
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1166
aaggcacagc cttttttaat 20
<210> 1167
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1167
attcggttat aaggcacagc 20
<210> 1168
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1168
cattcggtta taaggcacag 20
<210> 1169
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1169
tcattcggtt ataaggcaca 20
<210> 1170
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1170
ttcattcggt tataaggcac 20
<210> 1171
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1171
tttcattcgg ttataaggca 20
<210> 1172
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1172
agtttcattc ggttataagg 20
<210> 1173
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1173
aagtttcatt cggttataag 20
<210> 1174
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1174
taagtttcat tcggttataa 20
<210> 1175
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1175
ataagtttca ttcggttata 20
<210> 1176
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1176
cataagtttc attcggttat 20
<210> 1177
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1177
caatcataag tttcattcgg 20
<210> 1178
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1178
tatttcccac aatcataagt 20
<210> 1179
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1179
cactcccagt atttcccaca 20
<210> 1180
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1180
taattgctgc aataaggtgg 20
<210> 1181
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1181
ggttttcatt aattgctgca 20
<210> 1182
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1182
tctgatttct tggttttcat 20
<210> 1183
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1183
actgtggcac tttgcattcc 20
<210> 1184
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1184
tctatgccaa ctgtggcact 20
<210> 1185
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1185
tctttcacat ctatgccaac 20
<210> 1186
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1186
ttttgtctct tatttggata 20
<210> 1187
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1187
cgagatctct ctttcttttg 20
<210> 1188
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1188
catttaggac gagatctctc 20
<210> 1189
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1189
acgacctgca aaatcccaca 20
<210> 1190
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1190
agtactatag aattcctcac 20
<210> 1191
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1191
atagacagca aggtacaatg 20
<210> 1192
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1192
gctgaggtca tagacagcaa 20
<210> 1193
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1193
ctgtcccttg ctgaggtcat 20
<210> 1194
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1194
caaggcttca tggcatcaac 20
<210> 1195
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1195
ttgaagagcc aaggcttcat 20
<210> 1196
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1196
gcctttatat tgaagagcca 20
<210> 1197
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1197
tgccaacgag aatcacaggg 20
<210> 1198
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1198
ccaaatgtgt gccaacgaga 20
<210> 1199
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1199
cagaaacatc caaatgtgtg 20
<210> 1200
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1200
ttactcatgc aggctttgcg 20
<210> 1201
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1201
ttggtgattt tactcatgca 20
<210> 1202
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1202
ccctcgctta ttcaggagtt 20
<210> 1203
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1203
ggcagggaac cctcgcttat 20
<210> 1204
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1204
gcatcagatt cctcggtggc 20
<210> 1205
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1205
tttgccaaag catcagattc 20
<210> 1206
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1206
tcttgaaatt aaggctctcg 20
<210> 1207
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1207
gatctcggat cttgaaatta 20
<210> 1208
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1208
cagctgtcca acaacaagct 20
<210> 1209
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1209
gtctggaatc agctgtccaa 20
<210> 1210
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1210
tacatagcag tctggaatca 20
<210> 1211
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1211
tccgataaaa tgattttttc 20
<210> 1212
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1212
tttttacgct ccgataaaat 20
<210> 1213
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1213
attggcacat ttttacgctc 20
<210> 1214
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1214
gtttccggtc aattacggga 20
<210> 1215
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1215
ctcactagtt gtaataatcg 20
<210> 1216
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1216
ttcatctaac tgcagctgat 20
<210> 1217
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1217
gaagctcatt ttcatctaac 20
<210> 1218
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1218
actcctgatt catttagaaa 20
<210> 1219
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1219
tgaagaagga ctcctgattc 20
<210> 1220
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1220
tcttgaaaat gaagaaggac 20
<210> 1221
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1221
agtgctgggt cttgaaaatg 20
<210> 1222
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1222
aagtacaagt cacttaactg 20
<210> 1223
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1223
tgtcaaaatc tgtgccatga 20
<210> 1224
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1224
cactttcact gtcaaaatct 20
<210> 1225
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1225
acaaccttcc actttcactg 20
<210> 1226
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1226
gaaataatgc ccttagggtg 20
<210> 1227
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1227
tctctacgcg aaataatgcc 20
<210> 1228
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1228
ttttccacat ctctacgcga 20
<210> 1229
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1229
gaaagaaatt tttccacatc 20
<210> 1230
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1230
tggaaatttc cttttttttg 20
<210> 1231
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1231
tgtagttctt tggaaatttc 20
<210> 1232
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1232
actgtgacat gtagttcttt 20
<210> 1233
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1233
tggaattttt ctaggagctt 20
<210> 1234
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1234
caaagcaatc tggaattttt 20
<210> 1235
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1235
tcctattggc aaagcaatct 20
<210> 1236
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1236
atattcttct cctattggca 20
<210> 1237
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1237
actgcttgga accagcaaat 20
<210> 1238
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1238
gtcagacaaa ctgcttggaa 20
<210> 1239
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1239
aggcctgtgg tcagacaaac 20
<210> 1240
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1240
ctctatcaca ggcctgtggt 20
<210> 1241
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1241
gatgataatt tcagagttct 20
<210> 1242
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1242
atatagtcgg atgataattt 20
<210> 1243
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1243
aggcatttca tatagtcgga 20
<210> 1244
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1244
ttggaaaata aggcatttca 20
<210> 1245
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1245
ttaatcttga ccaaaatccc 20
<210> 1246
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1246
atcgattgat taatcttgac 20
<210> 1247
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1247
tctcaagtaa tcgattgatt 20
<210> 1248
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1248
ctccctgaaa gcatgtaagg 20
<210> 1249
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1249
ctgtttgggc gaagtgctcg 20
<210> 1250
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1250
tacattctgt ttgggcgaag 20
<210> 1251
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1251
atacattctg tttgggcgaa 20
<210> 1252
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1252
aatacattct gtttgggcga 20
<210> 1253
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1253
caatacattc tgtttgggcg 20
<210> 1254
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1254
ccaatacatt ctgtttgggc 20
<210> 1255
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1255
cgccaataca ttctgtttgg 20
<210> 1256
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1256
tcgccaatac attctgtttg 20
<210> 1257
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1257
gtcgccaata cattctgttt 20
<210> 1258
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1258
tgtcgccaat acattctgtt 20
<210> 1259
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1259
ttgtcgccaa tacattctgt 20
<210> 1260
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1260
tgccttgtcg ccaatacatt 20
<210> 1261
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1261
ttaagtaaat gccttgtcgc 20
<210> 1262
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1262
gagaccaatt taagtaaatg 20
<210> 1263
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1263
agatcctacc agacaataag 20
<210> 1264
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1264
taagacttca gatcctacca 20
<210> 1265
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1265
atgattgtct aagacttcag 20
<210> 1266
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1266
actctctgga tgattgtcta 20
<210> 1267
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1267
ggaactgtaa tttttaagaa 20
<210> 1268
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1268
ctacaagaag gaactgtaat 20
<210> 1269
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1269
cagccttttc tacaagaagg 20
<210> 1270
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1270
ggtccacaac ttggcccaaa 20
<210> 1271
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1271
aatcaatgtg gtccacaact 20
<210> 1272
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1272
ccatgagaga atcaatgtgg 20
<210> 1273
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1273
accattcttc catgagagaa 20
<210> 1274
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1274
caatctccag caacccagga 20
<210> 1275
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1275
ccacaaatat caatctccag 20
<210> 1276
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1276
tctccttcac cacaaatatc 20
<210> 1277
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1277
atttcttcaa cagagtttct 20
<210> 1278
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1278
catttcttca acagagtttc 20
<210> 1279
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1279
cccatttctt caacagagtt 20
<210> 1280
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1280
tgcccatttc ttcaacagag 20
<210> 1281
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1281
aatgcccatt tcttcaacag 20
<210> 1282
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1282
taatgcccat ttcttcaaca 20
<210> 1283
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1283
taaaactata taatgcccat 20
<210> 1284
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1284
caccatcatt aaaactatat 20
<210> 1285
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1285
atcaagtaag attttttgat 20
<210> 1286
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1286
catcaagtca tcaagtaaga 20
<210> 1287
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1287
tgctttcttc atcaagtcat 20
<210> 1288
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1288
tggatttact aagagatctc 20
<210> 1289
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1289
tggttgatct ggatttacta 20
<210> 1290
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1290
ggtgagcctt ggttgatctg 20
<210> 1291
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1291
cagccaaaat caagtcaggg 20
<210> 1292
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1292
taggcaggtc agccaaaatc 20
<210> 1293
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1293
atcattattc aacataatat 20
<210> 1294
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1294
ttccaactca tcattattca 20
<210> 1295
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1295
ttgttcaaat tccaactcat 20
<210> 1296
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1296
atcacctagg agaaactctg 20
<210> 1297
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1297
aaaactgcca tcacctagga 20
<210> 1298
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1298
aactgatcca aaactgccat 20
<210> 1299
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1299
tcttctcctt cataggctgc 20
<210> 1300
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1300
acagccactt cttctccttc 20
<210> 1301
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1301
acagcctgag tgatgtatgt 20
<210> 1302
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1302
cttgtcttaa cagcctgagt 20
<210> 1303
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1303
ccacaagctc ttgtcttaac 20
<210> 1304
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1304
agcaaagata tcaaactggg 20
<210> 1305
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1305
ccagctgcca gcaaagatat 20
<210> 1306
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1306
ggacgaatcc cagctgccag 20
<210> 1307
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1307
ggaggctaac tccatcacca 20
<210> 1308
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1308
ggaacccttg gaggctaact 20
<210> 1309
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1309
gcgatccaag gaacccttgg 20
<210> 1310
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1310
aggctggctt tgtcctgctg 20
<210> 1311
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1311
gttctagtga ggctggcttt 20
<210> 1312
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1312
tgctgtaggg ttctagtgag 20
<210> 1313
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1313
atctcaaacc atcagctacg 20
<210> 1314
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1314
agtggaggta tctcaaacca 20
<210> 1315
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1315
caggtctcgg tatataatca 20
<210> 1316
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1316
gaaaagcagc acattgtggg 20
<210> 1317
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1317
gcagcattgg gatacagtgt 20
<210> 1318
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1318
gcaatgatgg cagcattggg 20
<210> 1319
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1319
tatccccatt ctacagcagt 20
<210> 1320
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1320
tgatgttttt atccccattc 20
<210> 1321
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1321
cacgaaaccc tggtgtgccc 20
<210> 1322
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1322
cttcaggtgc acgaaaccct 20
<210> 1323
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1323
ctctggcaac ttcaggtgca 20
<210> 1324
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1324
agcctgttgg ttataaatga 20
<210> 1325
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1325
ataaacatca gcctgttggt 20
<210> 1326
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1326
accaaatgaa taaacatcag 20
<210> 1327
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1327
gttgtcaaaa tgtcatagag 20
<210> 1328
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1328
ctacctccag ttgtcaaaat 20
<210> 1329
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1329
tctactattc tacctccagt 20
<210> 1330
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1330
ttcaaaccct ctactattct 20
<210> 1331
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1331
atcaaactca tttggaaact 20
<210> 1332
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1332
ttctaattca tcaaactcat 20
<210> 1333
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1333
tccttgtatt tctaattcat 20
<210> 1334
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1334
tattctttaa ctggatcagg 20
<210> 1335
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1335
gcacaaccat attctttaac 20
<210> 1336
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1336
actgtttaat taatttctca 20
<210> 1337
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1337
ctttcaaaca ctgtttaatt 20
<210> 1338
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1338
gaggattttc tttcaaacac 20
<210> 1339
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1339
gacctgggca gaagtaggcc 20
<210> 1340
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1340
aatgtcaaag acctgggcag 20
<210> 1341
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1341
tgaattcaaa atgtcaaaga 20
<210> 1342
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1342
tttttaggta ataaaatgcg 20
<210> 1343
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1343
gtgtagcaac catgcattca 20
<210> 1344
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1344
cattcctgct gttgtgatgt 20
<210> 1345
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1345
gccaaatgct tgcattcctg 20
<210> 1346
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1346
agccaaatgc ttgcattcct 20
<210> 1347
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1347
cagccaaatg cttgcattcc 20
<210> 1348
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1348
ccagccaaat gcttgcattc 20
<210> 1349
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1349
cccagccaaa tgcttgcatt 20
<210> 1350
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1350
cagcccagcc aaatgcttgc 20
<210> 1351
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1351
acagcccagc caaatgcttg 20
<210> 1352
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1352
cacagcccag ccaaatgctt 20
<210> 1353
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1353
ccacagccca gccaaatgct 20
<210> 1354
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1354
gtgcccacag cccagccaaa 20
<210> 1355
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1355
tctgtcggtg tgcccacagc 20
<210> 1356
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1356
gagctgtcct ctgtcggtgt 20
<210> 1357
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1357
ccttcagtat ttaagtcaag 20
<210> 1358
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1358
gaagtgtatc cttcagtatt 20
<210> 1359
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1359
acttcctcag aagtgtatcc 20
<210> 1360
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1360
ctaagcacaa tattctacta 20
<210> 1361
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1361
gcaccaaggc taagcacaat 20
<210> 1362
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1362
caggaagatg caccaaggct 20
<210> 1363
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1363
agacacaatc cagctttcct 20
<210> 1364
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1364
ctgtgtccca gacacaatcc 20
<210> 1365
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1365
agtaccagac tgtgtcccag 20
<210> 1366
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1366
ccatcttcgg tattgatgac 20
<210> 1367
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1367
ctctttttcc catcttcggt 20
<210> 1368
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1368
agggtatgtc tctttttccc 20
<210> 1369
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1369
aatacaaaca agtgacagaa 20
<210> 1370
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1370
ggaaaaggaa ttgcaataca 20
<210> 1371
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1371
gttccaacca aaagaaaatt 20
<210> 1372
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1372
ccatcagcgg ttccaaccaa 20
<210> 1373
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1373
tcaaaaattg ctaacttgcc 20
<210> 1374
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1374
gtcttatctt caaaaattgc 20
<210> 1375
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1375
agcttaacag tcttatcttc 20
<210> 1376
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1376
gtatcttcaa aggagcagct 20
<210> 1377
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1377
cctatattta gtatcttcaa 20
<210> 1378
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1378
ctgacatttc ctatatttag 20
<210> 1379
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1379
ttcactcaaa cacatcaatg 20
<210> 1380
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1380
atttgtggat tcactcaaac 20
<210> 1381
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1381
ttccgttgaa tttgtggatt 20
<210> 1382
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1382
ccacatcctc cccacattac 20
<210> 1383
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1383
atctttgtgc cacatcctcc 20
<210> 1384
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1384
cattagaaaa ggagaaaatc 20
<210> 1385
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1385
gtttctgaat ggtgaaatca 20
<210> 1386
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1386
tctcaatgag tttctgaatg 20
<210> 1387
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1387
ttgttcttgt ctcaatgagt 20
<210> 1388
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1388
acagttggct tgttcttgtc 20
<210> 1389
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1389
tgaaagctgc ataagaaaac 20
<210> 1390
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1390
tggaatcact gaaagctgca 20
<210> 1391
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1391
ttatgatgtt ggaatcactg 20
<210> 1392
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1392
atagagagca gtgtctacca 20
<210> 1393
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1393
cttagcaata tagagagcag 20
<210> 1394
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1394
gctattttgc ttagcaatat 20
<210> 1395
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1395
ttcttatccc acacttccac 20
<210> 1396
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1396
tttttcagtt ttcttatccc 20
<210> 1397
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1397
tccacagagt ttttcagttt 20
<210> 1398
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1398
ttaaaaagtg cacgcagtct 20
<210> 1399
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1399
ttacctccct taaaaagtgc 20
<210> 1400
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1400
cttttaccat tacctccctt 20
<210> 1401
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1401
ccttgttttc ttttaccatt 20
<210> 1402
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1402
tcccagaata agacattttg 20
<210> 1403
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1403
ttttcactct cccagaataa 20
<210> 1404
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1404
agtgttcttc tgaaggcaga 20
<210> 1405
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1405
ccaaagagca gtgttcttct 20
<210> 1406
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1406
agttcctatc caaagagcag 20
<210> 1407
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1407
tccaggagta aaatatggcc 20
<210> 1408
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1408
gttgaaagat ccaggagtaa 20
<210> 1409
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1409
agtcgacgag ttgaaagatc 20
<210> 1410
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1410
accgaattac aaaagttgta 20
<210> 1411
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1411
atgactctga ccgaattaca 20
<210> 1412
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1412
gctgtcatca tgactctgac 20
<210> 1413
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1413
tgacattttt aaggcttcct 20
<210> 1414
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1414
ccaataccag catgacattt 20
<210> 1415
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1415
ggttgtagcc caataccagc 20
<210> 1416
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1416
ttgtgtacct tcagtatttt 20
<210> 1417
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1417
ctttctgctt ttgtgtacct 20
<210> 1418
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1418
attgtatctc tttctgcttt 20
<210> 1419
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1419
ttgatgtccc aaacggtcaa 20
<210> 1420
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1420
tgtggaagat tgatgtccca 20
<210> 1421
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1421
tgcacttcat gtggaagatt 20
<210> 1422
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1422
tctaaatttt gcacttcatg 20
<210> 1423
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1423
ttctcacttc aatgtgtttt 20
<210> 1424
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1424
ctaattcttt tctcacttca 20
<210> 1425
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1425
tcattttttc agctaattct 20
<210> 1426
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1426
ctatttctct cttactcaac 20
<210> 1427
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1427
agacaattcc tatttctctc 20
<210> 1428
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1428
ttcctatcca aagacaattc 20
<210> 1429
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1429
tatttacaag aggagagaat 20
<210> 1430
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1430
ccctttccat gtgaacattt 20
<210> 1431
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1431
accctttcca tgtgaacatt 20
<210> 1432
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1432
taccctttcc atgtgaacat 20
<210> 1433
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1433
gtaccctttc catgtgaaca 20
<210> 1434
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1434
agtacccttt ccatgtgaac 20
<210> 1435
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1435
tgagtaccct ttccatgtga 20
<210> 1436
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1436
gtgagtaccc tttccatgtg 20
<210> 1437
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1437
tgtgagtacc ctttccatgt 20
<210> 1438
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1438
atgtgagtac cctttccatg 20
<210> 1439
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1439
aatgtgagta ccctttccat 20
<210> 1440
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1440
aaaaaatgtg agtacccttt 20
<210> 1441
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1441
agctatttca aaaaatgtga 20
<210> 1442
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1442
atacacacga gctatttcaa 20
<210> 1443
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1443
cattccttca tacacacgag 20
<210> 1444
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1444
gtaagtattt ttacatatat 20
<210> 1445
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1445
tagttcttta aaatacacat 20
<210> 1446
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1446
ttgtgtttta aatagttctt 20
<210> 1447
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1447
aatataacat tgtgttttaa 20
<210> 1448
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1448
cgaaagtaac tggtatttat 20
<210> 1449
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1449
attaatgaac gaaagtaact 20
<210> 1450
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1450
ttttcattaa ttaatgaacg 20
<210> 1451
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1451
acagatttat tttcattaat 20
<210> 1452
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1452
agtacttaaa ttaggtactt 20
<210> 1453
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1453
tttagtatga gtacttaaat 20
<210> 1454
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1454
cttataaatt ttagtatgag 20
<210> 1455
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1455
cattacagac aagaaaacaa 20
<210> 1456
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1456
gtttacctcc attacagaca 20
<210> 1457
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1457
taaaataaag tttacctcca 20
<210> 1458
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1458
tagtcctgtc ttaagcacag 20
<210> 1459
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1459
gacaagcaat agtcctgtct 20
<210> 1460
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1460
agaaaaatcg acaagcaata 20
<210> 1461
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1461
attttcatta taccgtgcag 20
<210> 1462
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1462
actgtcttaa tattttcatt 20
<210> 1463
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1463
acatgggaaa ctgtcttaat 20
<210> 1464
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1464
atgcaatcta agaaggaata 20
<210> 1465
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1465
tgcatttcga tgcaatctaa 20
<210> 1466
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1466
atatgatagt gcatttcgat 20
<210> 1467
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1467
tacaagcata tatgatagtg 20
<210> 1468
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1468
gactttatta gtgcaaattc 20
<210> 1469
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1469
ggactttatt agtgcaaatt 20
<210> 1470
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1470
aggactttat tagtgcaaat 20
<210> 1471
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1471
aaggacttta ttagtgcaaa 20
<210> 1472
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1472
caaaggactt tattagtgca 20
<210> 1473
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1473
acaaaggact ttattagtgc 20
<210> 1474
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1474
aacaaaggac tttattagtg 20
<210> 1475
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1475
caacaaagga ctttattagt 20
<210> 1476
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1476
acagcaacaa agagaattca 20
<210> 1477
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1477
gcactgtttg caacagcaac 20
<210> 1478
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1478
gtgtaagatg cactgtttgc 20
<210> 1479
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1479
tttcttttga attgagtgaa 20
<210> 1480
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1480
taatggagtt ttcttttgaa 20
<210> 1481
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1481
tagtactttt aatggagttt 20
<210> 1482
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1482
tttgacagta tgtcatgttt 20
<210> 1483
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1483
tatgaggact ttgacagtat 20
<210> 1484
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1484
tttcctagat atgaggactt 20
<210> 1485
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1485
ttctgtgtct ttcctagata 20
<210> 1486
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1486
ttctgtgaca aagagagttt 20
<210> 1487
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1487
acagagagtt tctgtgacaa 20
<210> 1488
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1488
aggaaagaca cagagagttt 20
<210> 1489
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1489
gagttgaaaa acaactctat 20
<210> 1490
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1490
tcaaacatag agttgaaaaa 20
<210> 1491
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1491
tatccacatt caaacataga 20
<210> 1492
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1492
tacactaatt atacaaaatt 20
<210> 1493
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1493
cactgtattt acactaatta 20
<210> 1494
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1494
aggactgaac actgtattta 20
<210> 1495
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1495
atcacttgaa ggactgaaca 20
<210> 1496
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1496
acaagtagct agtggtatga 20
<210> 1497
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1497
gattagaaaa caagtagcta 20
<210> 1498
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1498
tagaatgaag cagattagaa 20
<210> 1499
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1499
ttagggaaaa gatgaatata 20
<210> 1500
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1500
atcacaaatt tagggaaaag 20
<210> 1501
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1501
atctgcagca tcacaaattt 20
<210> 1502
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1502
aaaggtttct atctgaatga 20
<210> 1503
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1503
ggaattctat aattctgaaa 20
<210> 1504
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1504
atggtcttgg taggagctgt 20
<210> 1505
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1505
tttatcctca tggtcttggt 20
<210> 1506
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1506
tgttagatat ttatcctcat 20
<210> 1507
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1507
gctcctttct ccttcagcaa 20
<210> 1508
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1508
ataactaaag ctcctttctc 20
<210> 1509
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1509
ttatccatca taactaaagc 20
<210> 1510
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1510
cagatatttt tatccatcat 20
<210> 1511
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1511
tttggaagcc tagggtggca 20
<210> 1512
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1512
taagtataat ttggaagcct 20
<210> 1513
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1513
taaacaattt aagtataatt 20
<210> 1514
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1514
tgatactcct attgtggtaa 20
<210> 1515
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1515
atttggccct gatactccta 20
<210> 1516
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1516
tacataggta tttggccctg 20
<210> 1517
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1517
ctaaagcaga aatgacctca 20
<210> 1518
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1518
gtacttttcc taaagcagaa 20
<210> 1519
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1519
ttaccgaaag tacttttcct 20
<210> 1520
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1520
tctgaaataa tgaatactgg 20
<210> 1521
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1521
agggaattat ctgaaataat 20
<210> 1522
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1522
attaaatgta ctagttgtcc 20
<210> 1523
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1523
tctgagaata ttaaatgtac 20
<210> 1524
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1524
gccataagtt ctgagaatat 20
<210> 1525
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1525
tagtaaaatg ccataagttc 20
<210> 1526
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1526
cacatagtaa aatgccataa 20
<210> 1527
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1527
tcacatagta aaatgccata 20
<210> 1528
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1528
ttcacatagt aaaatgccat 20
<210> 1529
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1529
tttcacatag taaaatgcca 20
<210> 1530
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1530
ttttcacata gtaaaatgcc 20
<210> 1531
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1531
agttttcaca tagtaaaatg 20
<210> 1532
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1532
aagttttcac atagtaaaat 20
<210> 1533
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1533
aaagttttca catagtaaaa 20
<210> 1534
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1534
taaagttttc acatagtaaa 20
<210> 1535
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1535
ttaaagtttt cacatagtaa 20
<210> 1536
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1536
taaatttaaa gttttcacat 20
<210> 1537
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1537
ttacccttaa tataaataaa 20
<210> 1538
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1538
agaatttgat tacccttaat 20
<210> 1539
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1539
gaaaatcttt catctttaag 20
<210> 1540
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1540
cctttaaaat acagaaaatc 20
<210> 1541
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1541
gcatagcttc ctttaaaata 20
<210> 1542
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1542
gttaattaca taacaagtta 20
<210> 1543
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1543
tattatatat gatttttttg 20
<210> 1544
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1544
gagataacac tggaacaaag 20
<210> 1545
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1545
acaatgaaag agataacact 20
<210> 1546
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1546
caaatacaaa gtaacaatga 20
<210> 1547
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1547
gtattcattt ttttaatttg 20
<210> 1548
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1548
tacctgctgc acactcgcga 20
<210> 1549
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1549
atccaagata catagcaaat 20
<210> 1550
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1550
taatagtcag atggaaaata 20
<210> 1551
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1551
tatcaagcag gagtgactct 20
<210> 1552
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1552
ctctctaggc agaaatacta 20
<210> 1553
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1553
atactttgcc tctggtactc 20
<210> 1554
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1554
caactatgat atatccaaaa 20
<210> 1555
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1555
aaaagatagg caggaaaaga 20
<210> 1556
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1556
tgccaaactc atctctgtac 20
<210> 1557
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1557
gtaaacaacg gctattttag 20
<210> 1558
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1558
cccagaaaca aaagcaagcc 20
<210> 1559
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1559
gtactgaaaa caagaagagc 20
<210> 1560
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1560
ggacatttaa agttacaatt 20
<210> 1561
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1561
tcttcttcac aactgcatgg 20
<210> 1562
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1562
tttacattat tggaagaaga 20
<210> 1563
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1563
ctttacatta ttggaagaag 20
<210> 1564
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1564
gctttacatt attggaagaa 20
<210> 1565
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1565
ggctttacat tattggaaga 20
<210> 1566
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1566
tggctttaca ttattggaag 20
<210> 1567
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1567
tttggcttta cattattgga 20
<210> 1568
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1568
gtttggcttt acattattgg 20
<210> 1569
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1569
tgtttggctt tacattattg 20
<210> 1570
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1570
ttgtttggct ttacattatt 20
<210> 1571
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1571
attgtttggc tttacattat 20
<210> 1572
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1572
gaataattca caatgtacac 20
<210> 1573
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1573
catgtgtgtt tgtttctttc 20
<210> 1574
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1574
attcaaacct tcccaatcac 20
<210> 1575
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1575
tccatcgcca aatggagaat 20
<210> 1576
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1576
aatactggaa taggagtagt 20
<210> 1577
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1577
tctcatgatc cttagtatga 20
<210> 1578
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1578
acctggccta ctcctgttcc 20
<210> 1579
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1579
atgcatatta gtctttttcc 20
<210> 1580
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1580
ctgccactgt aatcacctct 20
<210> 1581
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1581
tacatattgt ctaataatcc 20
<210> 1582
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1582
tttgttggca gtgatgtctc 20
<210> 1583
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1583
ttaaaaactt ttgatttctt 20
<210> 1584
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1584
aagggcaacc aatgtacaag 20
<210> 1585
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1585
tatgacctgt ttcctccatt 20
<210> 1586
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1586
ctatgacctg tttcctccat 20
<210> 1587
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1587
gctatgacct gtttcctcca 20
<210> 1588
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1588
agctatgacc tgtttcctcc 20
<210> 1589
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1589
cagctatgac ctgtttcctc 20
<210> 1590
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1590
atcagctatg acctgtttcc 20
<210> 1591
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1591
aatcagctat gacctgtttc 20
<210> 1592
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1592
aaaatcagct atgacctgtt 20
<210> 1593
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1593
taaaatcagc tatgacctgt 20
<210> 1594
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1594
atgtggtgaa tattatagaa 20
<210> 1595
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1595
ctttattgaa aattgccaca 20
<210> 1596
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1596
catttaagtt ggatagtgag 20
<210> 1597
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1597
ggaataaaat atacaatata 20
<210> 1598
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1598
agttcttctt aaaatgatcc 20
<210> 1599
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1599
aagcccacat tgaaaaaaca 20
<210> 1600
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1600
tgaaaataaa cagagaagat 20
<210> 1601
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1601
atgtgaaaat aaacagagaa 20
<210> 1602
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1602
agcctagaag cagttggttt 20
<210> 1603
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1603
aataataaca atatcccatc 20
<210> 1604
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1604
aagattgatg aaccacagga 20
<210> 1605
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1605
atttcatccc ttactgctta 20
<210> 1606
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1606
agagataatc aagagaaaaa 20
<210> 1607
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1607
agtatggagc tcctttacca 20
<210> 1608
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1608
tacattgaga tgtgtatatt 20
<210> 1609
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1609
tgctttagga gaagccttgg 20
<210> 1610
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1610
gtgctttagg agaagccttg 20
<210> 1611
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1611
tgtgctttag gagaagcctt 20
<210> 1612
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1612
gtgtgcttta ggagaagcct 20
<210> 1613
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1613
ggtgtgcttt aggagaagcc 20
<210> 1614
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1614
gaggtgtgct ttaggagaag 20
<210> 1615
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1615
tgaggtgtgc tttaggagaa 20
<210> 1616
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1616
atgaggtgtg ctttaggaga 20
<210> 1617
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1617
aatgaggtgt gctttaggag 20
<210> 1618
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1618
gaatgaggtg tgctttagga 20
<210> 1619
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1619
attttaaaac gatcagccag 20
<210> 1620
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1620
agttgggaac tcatcatagg 20
<210> 1621
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1621
aggctcacgg atatgaaaca 20
<210> 1622
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1622
aagagaggaa aaactgaaaa 20
<210> 1623
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1623
gtttacacat agaagtccgg 20
<210> 1624
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1624
taaagggata caagccattt 20
<210> 1625
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1625
tccttgagag cagcccctgt 20
<210> 1626
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1626
attcgagaac agcgattccc 20
<210> 1627
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1627
actgaacaaa gacatcaggg 20
<210> 1628
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1628
atgaacgagc tactcaagtt 20
<210> 1629
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1629
aagaaagttg atgaacgagc 20
<210> 1630
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1630
cctgccaatg tagccatttt 20
<210> 1631
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1631
gaataggaaa aatgtcacac 20
<210> 1632
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1632
gtcttactca atagtcacct 20
<210> 1633
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1633
tcttgatctc atccactcca 20
<210> 1634
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1634
caagtgtctt atgtttttct 20
<210> 1635
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1635
gattttatct tttataactt 20
<210> 1636
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1636
tctgtttact tatcagtctc 20
<210> 1637
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1637
gcagtaggta ctatgaactt 20
<210> 1638
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1638
cttgaactca ggtcatggca 20
<210> 1639
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1639
ctcacccccg accatgtgca 20
<210> 1640
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1640
cacaatgcta ttgtctttag 20
<210> 1641
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1641
cataatgtac atctttgcca 20
<210> 1642
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1642
aatgtctata taacaagtta 20
<210> 1643
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1643
tatatccctt cttaaagaat 20
<210> 1644
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1644
cgtgtggact gtaaattttt 20
<210> 1645
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1645
catcatgcta catgtaatgg 20
<210> 1646
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1646
tgctgggaat actatggtaa 20
<210> 1647
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1647
attccaatta catgccaagg 20
<210> 1648
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1648
atctgcatta atgcaaactg 20
<210> 1649
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1649
attcttctgg catgcctaaa 20
<210> 1650
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1650
tcatcttatg tctctaacca 20
<210> 1651
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1651
tactttgctg agtaccatcc 20
<210> 1652
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1652
aggaagtaac catgtcctca 20
<210> 1653
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1653
aaggaagtaa ccatgtcctc 20
<210> 1654
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1654
aaaggaagta accatgtcct 20
<210> 1655
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1655
aaaaggaagt aaccatgtcc 20
<210> 1656
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1656
taaaaggaag taaccatgtc 20
<210> 1657
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1657
attaaaagga agtaaccatg 20
<210> 1658
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1658
tattaaaagg aagtaaccat 20
<210> 1659
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1659
gtattaaaag gaagtaacca 20
<210> 1660
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1660
ggtattaaaa ggaagtaacc 20
<210> 1661
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1661
aggtattaaa aggaagtaac 20
<210> 1662
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1662
tatgtatcca aacatggatt 20
<210> 1663
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1663
ggtgacaaag tcttcatctg 20
<210> 1664
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1664
tttatttgag tctatttcct 20
<210> 1665
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1665
gggtgcatag tctgtaggta 20
<210> 1666
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1666
ggatttcaag agaaaaaatc 20
<210> 1667
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1667
atatctttac catgtatatg 20
<210> 1668
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1668
tccaaactca gaatgcacca 20
<210> 1669
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1669
gtctatgagt aatggcatgg 20
<210> 1670
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1670
ggattaaaat caatttatca 20
<210> 1671
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1671
aatttctttt ggcttgatac 20
<210> 1672
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1672
ttcaaattat gcgaatctga 20
<210> 1673
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1673
ttggacatca tttcatttat 20
<210> 1674
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1674
accttaaaag cccaggatct 20
<210> 1675
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1675
actttaaaga tgcagaaata 20
<210> 1676
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1676
aactttaaag atgcagaaat 20
<210> 1677
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1677
aaactttaaa gatgcagaaa 20
<210> 1678
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1678
caaactttaa agatgcagaa 20
<210> 1679
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1679
ccaaacttta aagatgcaga 20
<210> 1680
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1680
tgccaaactt taaagatgca 20
<210> 1681
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1681
ttgccaaact ttaaagatgc 20
<210> 1682
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1682
tttgccaaac tttaaagatg 20
<210> 1683
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1683
gtttgccaaa ctttaaagat 20
<210> 1684
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1684
ggtttgccaa actttaaaga 20
<210> 1685
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1685
ccaaatatgt ttcaccccag 20
<210> 1686
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1686
agcattttta caattaagga 20
<210> 1687
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1687
catactttag tctgtatttc 20
<210> 1688
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1688
ttattatata tcatgtttta 20
<210> 1689
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1689
gttattatat atcatgtttt 20
<210> 1690
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1690
agttattata tatcatgttt 20
<210> 1691
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1691
cagttattat atatcatgtt 20
<210> 1692
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1692
acagttatta tatatcatgt 20
<210> 1693
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1693
agacagttat tatatatcat 20
<210> 1694
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1694
aagacagtta ttatatatca 20
<210> 1695
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1695
aaagacagtt attatatatc 20
<210> 1696
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1696
caaagacagt tattatatat 20
<210> 1697
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1697
acaaagacag ttattatata 20
<210> 1698
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1698
ttcctgagtc agctgggcac 20
<210> 1699
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1699
gttgagtgta gttgagaagc 20
<210> 1700
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1700
aaagatgctt gtctaaagcc 20
<210> 1701
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1701
aataaatact ccctctctct 20
<210> 1702
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1702
actaaaaaga gtggaaatga 20
<210> 1703
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1703
ggcaaacata gtactttatt 20
<210> 1704
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1704
tgttgcttgc ttaaaagaaa 20
<210> 1705
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1705
tactgctcac agatatttat 20
<210> 1706
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1706
ctcttgtcaa tgccctacac 20
<210> 1707
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1707
gcaaaaaggt gttcattctt 20
<210> 1708
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1708
acttttcacc cagcaaaaag 20
<210> 1709
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1709
atgctatttc tattacccca 20
<210> 1710
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1710
accttcctct aaatgttatg 20
<210> 1711
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1711
ctgtcctgcc tttatttgtg 20
<210> 1712
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1712
tgttacttac ttgtttgttt 20
<210> 1713
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1713
ttgacttcat ggtactaaca 20
<210> 1714
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1714
caaagcattc cacaacatgt 20
<210> 1715
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1715
tgcattttca tcaacattag 20
<210> 1716
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1716
tttttggcat aagactagtt 20
<210> 1717
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1717
tctatgtttt tttaactggg 20
<210> 1718
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1718
caacagtagg aatagcaata 20
<210> 1719
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1719
gtttgctgag tgattcatta 20
<210> 1720
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1720
aatggtttga cttgagacac 20
<210> 1721
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1721
aattttcaaa gcgcatgaaa 20
<210> 1722
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1722
ttaattttca aagcgcatga 20
<210> 1723
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1723
gttaattttc aaagcgcatg 20
<210> 1724
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1724
tgttaatttt caaagcgcat 20
<210> 1725
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1725
tatgttaatt ttcaaagcgc 20
<210> 1726
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1726
atatgttaat tttcaaagcg 20
<210> 1727
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1727
aatatgttaa ttttcaaagc 20
<210> 1728
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1728
gaatatgtta attttcaaag 20
<210> 1729
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1729
tgaatatgtt aattttcaaa 20
<210> 1730
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1730
agaatgctca tgtactgctg 20
<210> 1731
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1731
cagaatgctc atgtactgct 20
<210> 1732
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1732
ctgtcacaac ttctatctag 20
<210> 1733
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1733
gtttcttaag tgggatacaa 20
<210> 1734
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1734
acttaaaatg ttttagacct 20
<210> 1735
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1735
aatacctcag cagatgctga 20
<210> 1736
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1736
cacattacta aaactgactt 20
<210> 1737
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1737
aaaccagtgt tctaagcttc 20
<210> 1738
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1738
aaatgatact aactgcaaac 20
<210> 1739
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1739
aagaaaatga tactaactgc 20
<210> 1740
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1740
taatctgcat atgggtttct 20
<210> 1741
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1741
agattattaa attatcataa 20
<210> 1742
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1742
tatttgaatt tcatgtttca 20
<210> 1743
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1743
tttttatgga gaccgctgga 20
<210> 1744
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1744
gtccattccc tttgtaaaat 20
<210> 1745
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1745
tggaaatttc acagtccatt 20
<210> 1746
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1746
tcattaacca aactactttt 20
<210> 1747
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1747
attatgagga taaaagaaaa 20
<210> 1748
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1748
aattatgagg ataaaagaaa 20
<210> 1749
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1749
caattatgag gataaaagaa 20
<210> 1750
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1750
ccaattatga ggataaaaga 20
<210> 1751
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1751
cccaattatg aggataaaag 20
<210> 1752
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1752
aacccaatta tgaggataaa 20
<210> 1753
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1753
gaacccaatt atgaggataa 20
<210> 1754
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1754
agaacccaat tatgaggata 20
<210> 1755
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1755
aagaacccaa ttatgaggat 20
<210> 1756
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1756
taagaaccca attatgagga 20
<210> 1757
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1757
agatctgttt ccattgcctg 20
<210> 1758
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1758
ctttaagtta cacattattt 20
<210> 1759
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1759
caaactatgt tatactttaa 20
<210> 1760
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1760
actcttcaga gtctgaaaag 20
<210> 1761
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1761
aactcttcag agtctgaaaa 20
<210> 1762
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1762
aaactcttca gagtctgaaa 20
<210> 1763
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1763
caaactcttc agagtctgaa 20
<210> 1764
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1764
tcaaactctt cagagtctga 20
<210> 1765
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1765
tgtcaaactc ttcagagtct 20
<210> 1766
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1766
gtgtcaaact cttcagagtc 20
<210> 1767
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1767
atagttggga acgaatagta 20
<210> 1768
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1768
tatagttggg aacgaatagt 20
<210> 1769
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1769
ttatagttgg gaacgaatag 20
<210> 1770
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1770
cttatagttg ggaacgaata 20
<210> 1771
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1771
tcttatagtt gggaacgaat 20
<210> 1772
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1772
tgtcttatag ttgggaacga 20
<210> 1773
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1773
atgtcttata gttgggaacg 20
<210> 1774
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1774
aatgtcttat agttgggaac 20
<210> 1775
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1775
gaatgtctta tagttgggaa 20
<210> 1776
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1776
agaatgtctt atagttggga 20
<210> 1777
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1777
taaggacaga gaccgagttt 20
<210> 1778
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1778
catttacatg ggattatttt 20
<210> 1779
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1779
atagctatta tacctcacct 20
<210> 1780
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1780
attgttaaga aggaaatgca 20
<210> 1781
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1781
actctggtat attttatgat 20
<210> 1782
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1782
agagattggg aaacattcag 20
<210> 1783
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1783
tatagcaaaa caactatgaa 20
<210> 1784
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1784
ccccaaaatt tcactcaaac 20
<210> 1785
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1785
tgtttgaagg aatagctgac 20
<210> 1786
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1786
gtgtttgaag gaatagctga 20
<210> 1787
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1787
tagtgtttga aggaatagct 20
<210> 1788
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1788
atagtgtttg aaggaatagc 20
<210> 1789
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1789
ccatagtgtt tgaaggaata 20
<210> 1790
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1790
gccatagtgt ttgaaggaat 20
<210> 1791
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1791
aagccatagt gtttgaagga 20
<210> 1792
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1792
aaagccatag tgtttgaagg 20
<210> 1793
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1793
aaaaagccat agtgtttgaa 20
<210> 1794
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1794
taaaaagcca tagtgtttga 20
<210> 1795
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1795
tctaaaaagc catagtgttt 20
<210> 1796
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1796
ttctaaaaag ccatagtgtt 20
<210> 1797
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1797
atcatgcaag cagcatttta 20
<210> 1798
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1798
catcatgcaa gcagcatttt 20
<210> 1799
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1799
gcatcatgca agcagcattt 20
<210> 1800
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1800
agcatcatgc aagcagcatt 20
<210> 1801
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1801
cagcatcatg caagcagcat 20
<210> 1802
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1802
tgcagcatca tgcaagcagc 20
<210> 1803
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1803
ttgcagcatc atgcaagcag 20
<210> 1804
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1804
cattgcagca tcatgcaagc 20
<210> 1805
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1805
tcattgcagc atcatgcaag 20
<210> 1806
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1806
ggagataata acagtggcta 20
<210> 1807
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1807
gtggaagtat taaggctact 20
<210> 1808
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1808
agtggaagta ttaaggctac 20
<210> 1809
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1809
tagtggaagt attaaggcta 20
<210> 1810
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1810
ttagtggaag tattaaggct 20
<210> 1811
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1811
tttagtggaa gtattaaggc 20
<210> 1812
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1812
tgtttagtgg aagtattaag 20
<210> 1813
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1813
ttgtttagtg gaagtattaa 20
<210> 1814
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1814
attgtttagt ggaagtatta 20
<210> 1815
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1815
tattgtttag tggaagtatt 20
<210> 1816
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1816
ttattgttta gtggaagtat 20
<210> 1817
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1817
ttgtcatagt taagtaacag 20
<210> 1818
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1818
aaacaagtaa tacagtatac 20
<210> 1819
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1819
atttcagatt tacaacagag 20
<210> 1820
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1820
tgttaaagct tgataatagg 20
<210> 1821
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1821
agcaccaaat tgttcctaac 20
<210> 1822
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1822
agcacacata atctatataa 20
<210> 1823
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1823
taccatctat catcaataaa 20
<210> 1824
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1824
ttctctgaca acaatgacaa 20
<210> 1825
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1825
tgtctgcaca gacacctgtt 20
<210> 1826
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1826
gtatctctta acccagagaa 20
<210> 1827
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1827
tgtatctctt aacccagaga 20
<210> 1828
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1828
atgtatctct taacccagag 20
<210> 1829
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1829
catgtatctc ttaacccaga 20
<210> 1830
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1830
tcatgtatct cttaacccag 20
<210> 1831
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1831
tttcatgtat ctcttaaccc 20
<210> 1832
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1832
ttttcatgta tctcttaacc 20
<210> 1833
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1833
gttttcatgt atctcttaac 20
<210> 1834
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1834
tgttttcatg tatctcttaa 20
<210> 1835
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1835
ctgttttcat gtatctctta 20
<210> 1836
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1836
aaattaactt ggtctttttc 20
<210> 1837
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1837
tctgttgctc ttagaatcta 20
<210> 1838
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1838
atggaacctt gaacttggga 20
<210> 1839
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1839
gattcagaaa cacttttata 20
<210> 1840
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1840
aagttgcttt gagaattttc 20
<210> 1841
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1841
aaatctagtc caacttcctc 20
<210> 1842
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1842
actcattggt aatggattat 20
<210> 1843
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1843
ttgcaatgtt tcaatatgct 20
<210> 1844
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1844
attgcaatgt ttcaatatgc 20
<210> 1845
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1845
gattgcaatg tttcaatatg 20
<210> 1846
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1846
tgattgcaat gtttcaatat 20
<210> 1847
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1847
ctgattgcaa tgtttcaata 20
<210> 1848
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1848
tgctgattgc aatgtttcaa 20
<210> 1849
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1849
ttgctgattg caatgtttca 20
<210> 1850
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1850
attgctgatt gcaatgtttc 20
<210> 1851
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1851
aattgctgat tgcaatgttt 20
<210> 1852
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1852
taattgctga ttgcaatgtt 20
<210> 1853
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1853
aatcggaaat ttaaattatc 20
<210> 1854
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1854
ttagtgacct aacagctcgg 20
<210> 1855
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1855
gtacagtatt tattgaatca 20
<210> 1856
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1856
atttatgcta tcatgtagtt 20
<210> 1857
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1857
aataatatat tcccaggaaa 20
<210> 1858
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1858
tagcaaccat gtggcctaga 20
<210> 1859
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1859
actgtcaaaa tctgaaagat 20
<210> 1860
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1860
agttagtttg acaattaaaa 20
<210> 1861
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1861
agtaactata cacataaagt 20
<210> 1862
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1862
caccggattt gctctttttt 20
<210> 1863
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1863
aatctactgc acacaacaca 20
<210> 1864
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1864
aatggagcca ttaattatta 20
<210> 1865
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1865
atttccttac cttttctaca 20
<210> 1866
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1866
gctttaaggt aaagtttttt 20
<210> 1867
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1867
gccagcattc aaaccctcaa 20
<210> 1868
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1868
atgagagtag attttaatag 20
<210> 1869
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1869
ctgagttcca aagcatttaa 20
<210> 1870
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1870
cacattttaa tgcaggaaaa 20
<210> 1871
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1871
tggatataag tgaatacaca 20
<210> 1872
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1872
atagtggccc ctaaatcctt 20
<210> 1873
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1873
tatagtggcc cctaaatcct 20
<210> 1874
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1874
atatagtggc ccctaaatcc 20
<210> 1875
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1875
catatagtgg cccctaaatc 20
<210> 1876
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1876
tcatatagtg gcccctaaat 20
<210> 1877
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1877
agtcatatag tggcccctaa 20
<210> 1878
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1878
tagtcatata gtggccccta 20
<210> 1879
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1879
atagtcatat agtggcccct 20
<210> 1880
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1880
catagtcata tagtggcccc 20
<210> 1881
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1881
ccatagtcat atagtggccc 20
<210> 1882
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1882
cttccaactc attctctctc 20
<210> 1883
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1883
gtggcctcag agctttctgc 20
<210> 1884
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1884
tccactgtgt agcctcattt 20
<210> 1885
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1885
aagccacatt tattaccttt 20
<210> 1886
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1886
gagaaataac acaaaacttt 20
<210> 1887
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1887
ggcactgaaa agtcccaagt 20
<210> 1888
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1888
agtaggaaat aggataagca 20
<210> 1889
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1889
ttaacatgta aggactgaaa 20
<210> 1890
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1890
tgatgacata tccaccacat 20
<210> 1891
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1891
tttagcttac tactatatat 20
<210> 1892
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1892
taatgcaagt aatacaaaaa 20
<210> 1893
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1893
ttctttaaca atcaatagag 20
<210> 1894
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1894
tatggatgaa aagtgaacat 20
<210> 1895
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1895
gaaattacct acacattaaa 20
<210> 1896
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1896
gacattttta atgtactaat 20
<210> 1897
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1897
aattttctat cctggaaaag 20
<210> 1898
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1898
agaaggagtt aagttagctc 20
<210> 1899
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1899
cagtgtagtc atactaacag 20
<210> 1900
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1900
acagtgtagt catactaaca 20
<210> 1901
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1901
cacagtgtag tcatactaac 20
<210> 1902
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1902
acacagtgta gtcatactaa 20
<210> 1903
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1903
cacacagtgt agtcatacta 20
<210> 1904
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1904
tgcacacagt gtagtcatac 20
<210> 1905
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1905
gtgcacacag tgtagtcata 20
<210> 1906
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1906
agtgcacaca gtgtagtcat 20
<210> 1907
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1907
cagtgcacac agtgtagtca 20
<210> 1908
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1908
acagtgcaca cagtgtagtc 20
<210> 1909
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1909
cttgctttat ggtaagaatg 20
<210> 1910
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1910
caagtctgga tcacacttgt 20
<210> 1911
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1911
aaaatttgat cagggaaatg 20
<210> 1912
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1912
gtggaatagt gatgaatccc 20
<210> 1913
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1913
agactattta aaaaatggga 20
<210> 1914
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1914
cacagtaatt ctgaaggctt 20
<210> 1915
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1915
ccttccccta ctgtcaacac 20
<210> 1916
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1916
ccccaggcac tgttttcctt 20
<210> 1917
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1917
gtttcagaga actagaataa 20
<210> 1918
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1918
acttcatcag aaactgctgg 20
<210> 1919
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1919
aaaattctga tttccaactc 20
<210> 1920
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1920
gtatgttaaa taagaattga 20
<210> 1921
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1921
caatgtgatg cttgcatttt 20
<210> 1922
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1922
tgacaccaaa ttagtcattt 20
<210> 1923
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1923
tgtactcaaa catgtatata 20
<210> 1924
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1924
ggtcacggcc agccccctgt 20
<210> 1925
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1925
aacatacact ttgaagtgtt 20
<210> 1926
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1926
gtttaggaga gactatagaa 20
<210> 1927
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1927
ggtttaggag agactataga 20
<210> 1928
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1928
tggtttagga gagactatag 20
<210> 1929
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1929
atggtttagg agagactata 20
<210> 1930
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1930
tatggtttag gagagactat 20
<210> 1931
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1931
catatggttt aggagagact 20
<210> 1932
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1932
gcatatggtt taggagagac 20
<210> 1933
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1933
tgcatatggt ttaggagaga 20
<210> 1934
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1934
ttgcatatgg tttaggagag 20
<210> 1935
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1935
gttgcatatg gtttaggaga 20
<210> 1936
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1936
tctatggaat ttcatccttt 20
<210> 1937
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1937
cagcaaaacc aggaagtcag 20
<210> 1938
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1938
gtattgttgc caaatgaatg 20
<210> 1939
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1939
tgtattgttg ccaaatgaat 20
<210> 1940
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1940
atgtattgtt gccaaatgaa 20
<210> 1941
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1941
aatgtattgt tgccaaatga 20
<210> 1942
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1942
caatgtattg ttgccaaatg 20
<210> 1943
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1943
ttcaatgtat tgttgccaaa 20
<210> 1944
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1944
gttcaatgta ttgttgccaa 20
<210> 1945
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1945
tgttcaatgt attgttgcca 20
<210> 1946
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1946
atgttcaatg tattgttgcc 20
<210> 1947
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1947
aatgttcaat gtattgttgc 20
<210> 1948
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1948
cacatccttt tacaatagtt 20
<210> 1949
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1949
aggatggaga catcgaattt 20
<210> 1950
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1950
aaggatggag acatcgaatt 20
<210> 1951
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1951
gaaggatgga gacatcgaat 20
<210> 1952
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1952
ggaaggatgg agacatcgaa 20
<210> 1953
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1953
tggaaggatg gagacatcga 20
<210> 1954
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1954
gttggaagga tggagacatc 20
<210> 1955
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1955
agttggaagg atggagacat 20
<210> 1956
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1956
gagttggaag gatggagaca 20
<210> 1957
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1957
agagttggaa ggatggagac 20
<210> 1958
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1958
aagagttgga aggatggaga 20
<210> 1959
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1959
tggatagaca gaaagttatc 20
<210> 1960
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1960
tccaggacag tgttttaaaa 20
<210> 1961
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1961
aatcttcatt gtagagaaaa 20
<210> 1962
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1962
gcggattttt taaaaagcct 20
<210> 1963
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1963
taaaaagaga cccaaataac 20
<210> 1964
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1964
tttaattctg tctctgtgtg 20
<210> 1965
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1965
gcttgagaag acctaagtaa 20
<210> 1966
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1966
gatggtaacc taaattaaaa 20
<210> 1967
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1967
agagctgtga catggccacc 20
<210> 1968
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1968
tctctagatt ctgtttttga 20
<210> 1969
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1969
ctggaaccca actagatcac 20
<210> 1970
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1970
tgattctaaa gcaaaacaca 20
<210> 1971
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1971
cttgcctggc agtgggaaaa 20
<210> 1972
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1972
aatgaaagac tggctccctt 20
<210> 1973
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1973
gttcagagat gtgctattta 20
<210> 1974
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1974
gcacaatatt tatcttcagg 20
<210> 1975
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1975
taatgttgag gcacaatatt 20
<210> 1976
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1976
aaagatctgt aatttcccca 20
<210> 1977
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1977
agcaatacaa atacagcata 20
<210> 1978
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1978
gtaggtagac caatgtagag 20
<210> 1979
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1979
attaataaaa tacctaggag 20
<210> 1980
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1980
tactaagatt acaatgagtt 20
<210> 1981
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1981
ttcctacaat caatacttaa 20
<210> 1982
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1982
gaactatgat ttatgctctt 20
<210> 1983
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1983
attgcatcag attgatgtac 20
<210> 1984
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1984
aaaaatcctc attcatggga 20
<210> 1985
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1985
taaagcatct atgctccaaa 20
<210> 1986
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1986
gcagacctag aactccaaaa 20
<210> 1987
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1987
aacaacgagg aatatgtaaa 20
<210> 1988
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1988
caaaatagac caaccagtcc 20
<210> 1989
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1989
catccaaaca taaacagaaa 20
<210> 1990
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1990
gttagccttt tatacctaga 20
<210> 1991
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1991
atctgtaact tttgaatgtt 20
<210> 1992
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1992
ggtcttgatc cccactcctt 20
<210> 1993
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1993
tatcaaggag acctgttggc 20
<210> 1994
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1994
aagttttaca tgaagtctca 20
<210> 1995
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1995
agctgttatg ggaacccaaa 20
<210> 1996
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1996
cgtccgctgc tcagggaacc 20
<210> 1997
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1997
aacgcactta acaatatcat 20
<210> 1998
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1998
atagcttcca ccacaatatt 20
<210> 1999
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 1999
tttgatgaag aatgcatcag 20
<210> 2000
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2000
cactttcagc cacttcagga 20
<210> 2001
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2001
aatatcattc ttgaaacact 20
<210> 2002
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2002
atccagggcc agcctcctta 20
<210> 2003
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2003
tgaagctcca gcttttcaag 20
<210> 2004
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2004
tctccacttt aggacaagcc 20
<210> 2005
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2005
gatgcagttt ctctactcta 20
<210> 2006
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2006
ggatgagtac tatagaattc 20
<210> 2007
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2007
ttccggtcaa ttacgggaaa 20
<210> 2008
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2008
atctggaatt tttctaggag 20
<210> 2009
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2009
caggaaacca ttcttccatg 20
<210> 2010
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2010
gtttattaaa aatcttcaca 20
<210> 2011
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2011
aatgcttgca ttcctgctgt 20
<210> 2012
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2012
tccacaacag ggctattttg 20
<210> 2013
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2013
aattcatttg aatatttaca 20
<210> 2014
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2014
gttaaagcat agcttccttt 20
<210> 2015
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2015
aatgaaggtg gccagaatca 20
<210> 2016
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2016
aagtgagtat taaaatgtca 20
<210> 2017
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2017
caaaatgtaa gttatcagaa 20
<210> 2018
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2018
tcaataatgt ttagttagtt 20
<210> 2019
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2019
actatagtac atgtatctca 20
<210> 2020
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2020
ttatacatga cagcctgaag 20
<210> 2021
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2021
agaacactta ttacatacca 20
<210> 2022
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2022
tttttgacac tccttttaaa 20
<210> 2023
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2023
acgatcattc cttattattc 20
<210> 2024
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2024
ggcacgacaa tattcattgt 20
<210> 2025
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2025
caacctgctg gctagtcacc 20
<210> 2026
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2026
taattataca aagctataag 20
<210> 2027
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2027
atagaacatt ttacacacta 20
<210> 2028
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2028
aaccgccagc tatataatct 20
<210> 2029
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2029
aggtgataac agatgtcagt 20
<210> 2030
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2030
agtaatagat tgaaagaaac 20
<210> 2031
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2031
ttaatagtat aaatacagaa 20
<210> 2032
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2032
ccgactgctg aggttacacc 20
<210> 2033
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2033
gtgagggaga ggacataaag 20
<210> 2034
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2034
tgtattacat aggtatgact 20
<210> 2035
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2035
ctttaaagat gcagaaataa 20
<210> 2036
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2036
ttacccgtgc atgcacctgt 20
<210> 2037
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2037
atattaaata cagtaaggtt 20
<210> 2038
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2038
ccattcactc cttactttgt 20
<210> 2039
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2039
aaagataaaa atagtgtcag 20
<210> 2040
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2040
ctcaagtttt tccagatgat 20
<210> 2041
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2041
aggtttctta agtgggatac 20
<210> 2042
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2042
gcttagagac aaattaaggg 20
<210> 2043
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2043
ttatatataa attcgaaaga 20
<210> 2044
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2044
tcagatctgt ttccattgcc 20
<210> 2045
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2045
caatttctaa ttttataatg 20
<210> 2046
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2046
atttcctcta ttatttcata 20
<210> 2047
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2047
aatacagtat acaggccagt 20
<210> 2048
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2048
cattaccttt cttgatttat 20
<210> 2049
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2049
tttcctttcc catcttcatg 20
<210> 2050
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2050
gaggacaaaa aatgatctct 20
<210> 2051
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2051
ctaaatttgt tttcttatga 20
<210> 2052
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2052
accagggagg caatatagaa 20
<210> 2053
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2053
ccacatggag aagcaccaat 20
<210> 2054
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2054
aaagtcaatg aaggtaatca 20
<210> 2055
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2055
attaaggcaa atacaaagat 20
<210> 2056
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2056
gctgcattaa tatggagtat 20
<210> 2057
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2057
tgcccttcca actcaatcac 20
<210> 2058
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2058
ttatagataa aacttgaaga 20
<210> 2059
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2059
atgctttaaa ctgtgattgc 20
<210> 2060
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2060
ttaagatgat gggttctaga 20
<210> 2061
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2061
tgcaagaaac acaagttgga 20
<210> 2062
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2062
atgcacagga aatcttattc 20
<210> 2063
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2063
atattggaga ttaaaaggga 20
<210> 2064
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2064
tttacaaacg acataatcct 20
<210> 2065
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2065
agacccaaat aacgatttaa 20
<210> 2066
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2066
ccaaatcaag agctcacaac 20
<210> 2067
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2067
tagtactttt tttccaatac 20
<210> 2068
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2068
agatattcat gctcacagac 20
<210> 2069
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2069
tgttgtcaga gagccactac 20
<210> 2070
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2070
gaagcattac aaattttttt 20
<210> 2071
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2071
ccaaagtaca tacaattcaa 20
<210> 2072
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2072
tttccttcct ggacattgtt 20
<210> 2073
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2073
taacgcactt aacaatatca 20
<210> 2074
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2074
tcatagcttc caccacaata 20
<210> 2075
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2075
cttcctttga tgaagaatgc 20
<210> 2076
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2076
ccactttcag ccacttcagg 20
<210> 2077
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2077
gaatccatag caccttccag 20
<210> 2078
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2078
tatacaaaat cctccaaggc 20
<210> 2079
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2079
ttcacatagc tgttgtggaa 20
<210> 2080
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2080
gaaactctcc actttaggac 20
<210> 2081
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2081
gggatgagta ctatagaatt 20
<210> 2082
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2082
tttccggtca attacgggaa 20
<210> 2083
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2083
caatctggaa tttttctagg 20
<210> 2084
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2084
agagtttctc cttcaccaca 20
<210> 2085
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2085
aaagcaccac aagctcttgt 20
<210> 2086
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2086
caaatgcttg cattcctgct 20
<210> 2087
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2087
tattagtcca cagagttttt 20
<210> 2088
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2088
gaagttgtgt aagatgcact 20
<210> 2089
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2089
gagctctatt atatatgatt 20
<210> 2090
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2090
ttatctagac cctgcagacc 20
<210> 2091
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2091
gaaggaaaaa tactactttt 20
<210> 2092
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2092
agttttagag gttgtaccaa 20
<210> 2093
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2093
gtagtgggcc ggtggccgtt 20
<210> 2094
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2094
gcttaattgc tctacagtcc 20
<210> 2095
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2095
atcctaattg tcatcgaaag 20
<210> 2096
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2096
ataaaataca tattgtctaa 20
<210> 2097
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2097
tatagaacta catctataaa 20
<210> 2098
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2098
tacaagttgc tacaatggag 20
<210> 2099
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2099
atgtcatgtc tgtgacacac 20
<210> 2100
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2100
ttatgatgtt tgaatggcac 20
<210> 2101
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2101
attttttgcc ctctaaaaat 20
<210> 2102
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2102
cccagcaaat gctgctggtc 20
<210> 2103
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2103
tgtgccaatt atttttttta 20
<210> 2104
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2104
aatacagaca taggtgtttt 20
<210> 2105
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2105
ttcttaaaga atttcacatt 20
<210> 2106
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2106
tttcacttcc cacatcccca 20
<210> 2107
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2107
cacagcactt acttgctctc 20
<210> 2108
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2108
aattccagga accacaaact 20
<210> 2109
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2109
tcagtacagg ttaatgatga 20
<210> 2110
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2110
cagcttcatg taataggttt 20
<210> 2111
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2111
cctctaatat tacatattaa 20
<210> 2112
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2112
aatccatagg caagtgggat 20
<210> 2113
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2113
accatttctc ctcccggctc 20
<210> 2114
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2114
aaaagataaa aatagtgtca 20
<210> 2115
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2115
ttccttgacc catcacttta 20
<210> 2116
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2116
aaggtttctt aagtgggata 20
<210> 2117
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2117
tggccttctg cttagagaca 20
<210> 2118
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2118
actacttttt ataactaaat 20
<210> 2119
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2119
atcagatctg tttccattgc 20
<210> 2120
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2120
tttgaattaa tgatttaaca 20
<210> 2121
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2121
gaattcctgt ttattgtcat 20
<210> 2122
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2122
agctgaaaaa caagtaatac 20
<210> 2123
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2123
aattagagaa aaagactaaa 20
<210> 2124
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2124
aagaaaagaa caactgtcct 20
<210> 2125
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2125
agaggacaaa aaatgatctc 20
<210> 2126
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2126
acattatgaa tgtcatttga 20
<210> 2127
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2127
tcctgattaa cattctttaa 20
<210> 2128
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2128
atctgcttca tttctcttgg 20
<210> 2129
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2129
gcaaatgatt ttactgctta 20
<210> 2130
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2130
cttatttgcc tcccatatcc 20
<210> 2131
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2131
tttttaaagc ccttctctat 20
<210> 2132
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2132
ctacacttcc aactttgtgt 20
<210> 2133
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2133
gaaacctgta agagacagtc 20
<210> 2134
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2134
gtgtgatgtt aaattgattc 20
<210> 2135
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2135
catttttata gaaggcagat 20
<210> 2136
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2136
actctcctac tagactgtaa 20
<210> 2137
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2137
attctcttct ttttattcag 20
<210> 2138
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2138
attaggccct gggtttctga 20
<210> 2139
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2139
aagataaaac atatccctaa 20
<210> 2140
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2140
tttatgtaaa tttacttgtc 20
<210> 2141
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2141
taaagtcatt atagttgtac 20
<210> 2142
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2142
aaaaaacagg cttcacattt 20
<210> 2143
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2143
atctctataa ggaaacctga 20
<210> 2144
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2144
tttaacaatc attagtatat 20
<210> 2145
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2145
gagaacattc tttgtaatac 20
<210> 2146
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2146
tgagaagaac tggatgttca 20
<210> 2147
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2147
agacgatcaa cagaggcaca 20
<210> 2148
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2148
gttaacgcac ttaacaatat 20
<210> 2149
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2149
ttcatagctt ccaccacaat 20
<210> 2150
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2150
tttctgaaat taacattttg 20
<210> 2151
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2151
agccactttc agccacttca 20
<210> 2152
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2152
ctgaatccat agcaccttcc 20
<210> 2153
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2153
tttcctatac aaaatcctcc 20
<210> 2154
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2154
aaactcttca gagtttcaca 20
<210> 2155
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2155
caagaaaggc atagcagcaa 20
<210> 2156
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2156
aagatgcagt ttctctactc 20
<210> 2157
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2157
ttcagcctgt cccttgctga 20
<210> 2158
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2158
cgtttccggt caattacggg 20
<210> 2159
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2159
gggaagctct atcacaggcc 20
<210> 2160
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2160
tataatgccc atttcttcaa 20
<210> 2161
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2161
gtggcaaagc accacaagct 20
<210> 2162
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2162
ccaaatgctt gcattcctgc 20
<210> 2163
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2163
ttttgtgttt tgattccttg 20
<210> 2164
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2164
tttcattagt acttttaatg 20
<210> 2165
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2165
aaattgcaaa tacaaagtaa 20
<210> 2166
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2166
ctgggttgtc aagtatagca 20
<210> 2167
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2167
tatcatgtta aatggcatct 20
<210> 2168
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2168
catataattt ctaaattatg 20
<210> 2169
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2169
gttgatatat taaaatatag 20
<210> 2170
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2170
attctcatct agaatgcaaa 20
<210> 2171
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2171
tactctacat ttatagtcat 20
<210> 2172
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2172
gaaggctcac accttcagat 20
<210> 2173
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2173
tatacaacat ttaagttgga 20
<210> 2174
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2174
catctgtgta taaatatgta 20
<210> 2175
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2175
ctgattccct ctcatgtcat 20
<210> 2176
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2176
actccttgct acagcttgta 20
<210> 2177
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2177
ggtgagatga aaaaggagga 20
<210> 2178
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2178
ctgtttatca agttccccca 20
<210> 2179
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2179
gttttcactg caacttctgt 20
<210> 2180
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2180
taaatgtgtt ggatgaatac 20
<210> 2181
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2181
tagagtttca tatccctttg 20
<210> 2182
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2182
gagtggattt atgttactgg 20
<210> 2183
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2183
ccacatcaca gcacttactt 20
<210> 2184
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2184
catagtctgt aggtagtagt 20
<210> 2185
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2185
cgttaataat tttcaaacaa 20
<210> 2186
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2186
cttgaccagt aaaacgcaat 20
<210> 2187
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2187
cagagtctgt cctcttcact 20
<210> 2188
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2188
gtttatgtga ttttaattca 20
<210> 2189
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2189
aagcactaca gagctctgat 20
<210> 2190
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2190
ctgaccaaaa ctggtgtttt 20
<210> 2191
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2191
tttcctggaa tattaaccat 20
<210> 2192
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2192
aaaaggtttc ttaagtggga 20
<210> 2193
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2193
ctggccttct gcttagagac 20
<210> 2194
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2194
atataatttc tcattaacca 20
<210> 2195
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2195
taatcagatc tgtttccatt 20
<210> 2196
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2196
tatttgaatt aatgatttaa 20
<210> 2197
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2197
tattctctat gaaggaagat 20
<210> 2198
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2198
gacaaacaaa ttatcaattt 20
<210> 2199
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2199
tcttttacat gtcacactat 20
<210> 2200
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2200
tgttgatatt tgctttccgt 20
<210> 2201
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2201
tgaaaaataa atgagaggac 20
<210> 2202
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2202
gagaattttc atctttgaga 20
<210> 2203
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2203
ttatttgtcc ccatacatga 20
<210> 2204
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2204
gtagcagaat taatattttt 20
<210> 2205
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2205
ccaaccttgt tgagcaaatg 20
<210> 2206
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2206
cacctgaaaa ctgtcttatt 20
<210> 2207
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2207
actggaatca gaaatagaat 20
<210> 2208
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2208
aattaagctg tccaagcgaa 20
<210> 2209
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2209
tgaatgtgaa gaatgcccat 20
<210> 2210
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2210
tagcttgtgt gatgttaaat 20
<210> 2211
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2211
gactcatctt tcctcattgg 20
<210> 2212
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2212
tgactctcct actagactgt 20
<210> 2213
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2213
cattctcttc tttttattca 20
<210> 2214
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2214
aaaagattag gccctgggtt 20
<210> 2215
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2215
attatacatt tccttagaat 20
<210> 2216
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2216
tatttatgta aatttacttg 20
<210> 2217
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2217
atttttactg tggacataaa 20
<210> 2218
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2218
ggtacaaaaa acaggcttca 20
<210> 2219
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2219
aacaaagatg atgaacgatc 20
<210> 2220
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2220
atgaatgaac aacgaggaat 20
<210> 2221
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2221
tgtgacagaa ctatgtcaaa 20
<210> 2222
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2222
aatatagcat agtaattgag 20
<210> 2223
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2223
gtccaagacg atcaacagag 20
<210> 2224
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2224
agggaatgta aacaatgcag 20
<210> 2225
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2225
tttcatagct tccaccacaa 20
<210> 2226
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2226
gtatttttct gaaattaaca 20
<210> 2227
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2227
cagccacttt cagccacttc 20
<210> 2228
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2228
ttctttgtaa tcaagtatcc 20
<210> 2229
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2229
ccaagccaag aaggttcaac 20
<210> 2230
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2230
tcaaactctt cagagtttca 20
<210> 2231
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2231
ggaggcaaga aaggcatagc 20
<210> 2232
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2232
gaaagatgca gtttctctac 20
<210> 2233
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2233
tcaacttcag cctgtccctt 20
<210> 2234
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2234
ttttctctca ctagttgtaa 20
<210> 2235
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2235
tttcatatag tcggatgata 20
<210> 2236
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2236
gttcttcacc atcattaaaa 20
<210> 2237
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2237
aagcaggcga tccaaggaac 20
<210> 2238
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2238
aaatgagagc tgtcctctgt 20
<210> 2239
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2239
agagggtttt cactctccca 20
<210> 2240
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2240
tgttttttca ttagtacttt 20
<210> 2241
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2241
aatatggtat tcattttttt 20
<210> 2242
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2242
atgctcaggc ttgggcaatt 20
<210> 2243
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2243
tggaatatca tgttaaatgg 20
<210> 2244
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2244
aaataaatac tcaaggccat 20
<210> 2245
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2245
tattttcacc caactccata 20
<210> 2246
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2246
tttgcattct catctagaat 20
<210> 2247
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2247
cccctgagtc ctggagaacc 20
<210> 2248
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2248
attgggtttt actctgccta 20
<210> 2249
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2249
ccacatgcaa aaatatttct 20
<210> 2250
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2250
acatctgtgt ataaatatgt 20
<210> 2251
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2251
gatgaatatt caatggcatt 20
<210> 2252
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2252
aaaacacaaa ggctcacgga 20
<210> 2253
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2253
ctgtcagtgc cctggccact 20
<210> 2254
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2254
gtggctagct tctagccaag 20
<210> 2255
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2255
tgttattatc attcctcttt 20
<210> 2256
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2256
aaagcctttt atatatgcat 20
<210> 2257
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2257
ctttttaagt cctccatatt 20
<210> 2258
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2258
agaaaacagc agccatagta 20
<210> 2259
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2259
aagtgatttt ctccacatca 20
<210> 2260
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2260
tgcatagtct gtaggtagta 20
<210> 2261
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2261
tgttgtcacc cttgtaaaat 20
<210> 2262
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2262
aattcactga gggttagaat 20
<210> 2263
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2263
agcacatccc cagagtctgt 20
<210> 2264
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2264
taaattgaaa gaatagtaga 20
<210> 2265
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2265
aaatgcccac cagtctccaa 20
<210> 2266
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2266
aaaccttgat gtataaaggc 20
<210> 2267
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2267
tacacaagcc acgaaaggat 20
<210> 2268
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2268
tcttcattga cacaccacac 20
<210> 2269
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2269
tcactctggc cttctgctta 20
<210> 2270
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2270
atatccatat aatttctcat 20
<210> 2271
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2271
gaattaaatg attaaagtat 20
<210> 2272
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2272
ttttgtaaat tatttccaga 20
<210> 2273
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2273
aaaaattatt ttactgagtc 20
<210> 2274
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2274
tgagacaaac aaattatcaa 20
<210> 2275
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2275
cgctgttgaa gaaacctagt 20
<210> 2276
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2276
gagcctggag ggaaagacac 20
<210> 2277
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2277
gatcaaaggc aaatatgaaa 20
<210> 2278
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2278
atttctagca aggtaatatg 20
<210> 2279
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2279
gtacaggatg cagctaccta 20
<210> 2280
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2280
gttactagaa tgtagcagaa 20
<210> 2281
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2281
catctcccta atttctctaa 20
<210> 2282
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2282
gtcattttat aaaatatggc 20
<210> 2283
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2283
aactgttaca tactggaatc 20
<210> 2284
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2284
atgtgcaatt taatataatt 20
<210> 2285
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2285
acttgtggcc cacaggtcgc 20
<210> 2286
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2286
tgttgaaatg tatagcttgt 20
<210> 2287
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2287
gacatgtgag atggtcatgc 20
<210> 2288
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2288
tcttcatagc ttaaagtaaa 20
<210> 2289
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2289
gaatctacaa atctaacttt 20
<210> 2290
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2290
aaaattggag gcagagttta 20
<210> 2291
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2291
atattgttac agatacaatg 20
<210> 2292
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2292
ctccataatc ctatatttat 20
<210> 2293
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2293
aagtatgtct aagcttttta 20
<210> 2294
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2294
ttgaaatttt tctttgacca 20
<210> 2295
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2295
tttccatctt aaatgattag 20
<210> 2296
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2296
aatagaagaa ggcactacag 20
<210> 2297
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2297
aaataaaaat ataaagtggc 20
<210> 2298
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2298
tgaggcaaaa tatagcatag 20
<210> 2299
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2299
ctgctgcaca ctcgcgactc 20
<210> 2300
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2300
tccacattat tgcaaggaat 20
<210> 2301
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2301
cctatggagc aaacagcaac 20
<210> 2302
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2302
cttctgcatt aactccaaaa 20
<210> 2303
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2303
ttacagccac tttcagccac 20
<210> 2304
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2304
ttagtctgta tttcagcaac 20
<210> 2305
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2305
ttcttgctag tgtagatgct 20
<210> 2306
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2306
tgtcaaactc ttcagagttt 20
<210> 2307
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2307
aagaccgcaa gtgtggaaga 20
<210> 2308
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2308
ctgacatcca gagatgtcag 20
<210> 2309
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2309
aagaagcgcg agcctttata 20
<210> 2310
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2310
aactgcagtg ctgggtcttg 20
<210> 2311
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2311
gcatttcata tagtcggatg 20
<210> 2312
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2312
ttcctctgct ttcttcatca 20
<210> 2313
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2313
atcctgtgct gtagggttct 20
<210> 2314
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2314
tcagcaactt cctcagaagt 20
<210> 2315
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2315
tggcctcctc cagttcctat 20
<210> 2316
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2316
ctattatgtc taggaaagac 20
<210> 2317
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2317
ctccttaaga gtccgggttt 20
<210> 2318
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2318
tgacactcat aactactccg 20
<210> 2319
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2319
aatacaatta aattggtagt 20
<210> 2320
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2320
aaaatctaca acttaaccag 20
<210> 2321
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2321
aaaaagttaa aagcactact 20
<210> 2322
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2322
ctttaagaat atctcctaca 20
<210> 2323
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2323
agtgatcaac attcattttt 20
<210> 2324
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2324
ttattgttca gccccaccca 20
<210> 2325
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2325
ctatcctgtg aacaatattg 20
<210> 2326
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2326
tatatttata tacatctgtg 20
<210> 2327
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2327
agttaagtga aacattagct 20
<210> 2328
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2328
aacaaataga cggtcaagat 20
<210> 2329
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2329
tccctgtcca gacctcttta 20
<210> 2330
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2330
atactgccag agcctgaaaa 20
<210> 2331
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2331
ttagttagac tgatgttaaa 20
<210> 2332
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2332
gaagaaatta tttgtgcctc 20
<210> 2333
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2333
gaggtcctac tattcaaatg 20
<210> 2334
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2334
cttctctttt tcatactcag 20
<210> 2335
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2335
agaagactgg ttttacttta 20
<210> 2336
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2336
ggtgcatagt ctgtaggtag 20
<210> 2337
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2337
ttcacaggtg tgtatttcac 20
<210> 2338
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2338
aaatcagtat ccttgatttt 20
<210> 2339
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2339
ggaaaaagaa ctaataccct 20
<210> 2340
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2340
aaaatcctgt tgggtagaaa 20
<210> 2341
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2341
cccttacagc tagcaagcaa 20
<210> 2342
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2342
aacttttgga gcctactgag 20
<210> 2343
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2343
tcattatata tttcaccata 20
<210> 2344
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2344
taagaataag gtataaatca 20
<210> 2345
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2345
attttaaatt cccctactct 20
<210> 2346
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2346
tgagtgaaaa agctatatcc 20
<210> 2347
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2347
agagctatcc tatcaacaaa 20
<210> 2348
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2348
cttacacacc tctggtaact 20
<210> 2349
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2349
tttgtctgtg ctctgaactt 20
<210> 2350
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2350
cctaattgga gtaatttctt 20
<210> 2351
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2351
tccatacagt ctaccaggtt 20
<210> 2352
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2352
ggcatcaaaa acattttctc 20
<210> 2353
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2353
agatgcctgc tctgctaatg 20
<210> 2354
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2354
ttcacacata agtagaaatt 20
<210> 2355
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2355
ctgtataaga tatacccatc 20
<210> 2356
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2356
tgctattcat atagagtctc 20
<210> 2357
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2357
attttggaaa ccagtaacac 20
<210> 2358
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2358
tttgagtatg tcaccatgta 20
<210> 2359
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2359
attagttagg attgttggta 20
<210> 2360
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2360
aggattctca gatacagtgt 20
<210> 2361
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2361
aatcctatgg tgagtacctc 20
<210> 2362
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2362
gatccaatgg caacaaccct 20
<210> 2363
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2363
ggaatgtaag gtgactctca 20
<210> 2364
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2364
agactagcaa aatagctttt 20
<210> 2365
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2365
gtggacctga atttgatttg 20
<210> 2366
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2366
aggaagattc attaaacgga 20
<210> 2367
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2367
aaagatggag ctcagcagtc 20
<210> 2368
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2368
tttgccttat aactattttt 20
<210> 2369
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2369
attctgtttt tgatctggag 20
<210> 2370
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2370
ccttgcccaa ttccatccat 20
<210> 2371
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2371
tattcttgtt tgaaactggt 20
<210> 2372
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2372
ccctcacact agattatgag 20
<210> 2373
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2373
agaaaaactg tcagatgaat 20
<210> 2374
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2374
atattctagt gaagagacta 20
<210> 2375
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2375
ctttgcattg tacctggaca 20
<210> 2376
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2376
gacttccaca ttattgcaag 20
<210> 2377
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2377
atagtctcag tgaggagggc 20
<210> 2378
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2378
gagaatgtat atgcttctgc 20
<210> 2379
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2379
tatatccagg gaagtgttgc 20
<210> 2380
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2380
agaaaaagat gctgacaatt 20
<210> 2381
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2381
gccttcactt ccttcactat 20
<210> 2382
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2382
ccaaatgtgt caaactcttc 20
<210> 2383
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2383
ttatggctaa ataagagttc 20
<210> 2384
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2384
gatgcagttc atccaaagga 20
<210> 2385
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2385
ttttccgaag ttttgccaaa 20
<210> 2386
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2386
gggtgttttg gacaaccttc 20
<210> 2387
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2387
taaggcattt catatagtcg 20
<210> 2388
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2388
tgagccttgg ttgatctgga 20
<210> 2389
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2389
aatcatggct gagtggaggt 20
<210> 2390
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2390
ttccttttca acaggaagat 20
<210> 2391
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2391
ttcctagctg tgctgtcatc 20
<210> 2392
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2392
gaagcagatt agaaaacaag 20
<210> 2393
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2393
ctttacctgc tgcacactcg 20
<210> 2394
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2394
ccagagactg gaaatgaaag 20
<210> 2395
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2395
tccattaatc tattcaatta 20
<210> 2396
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2396
gtatcgattc tattattaaa 20
<210> 2397
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2397
aatcaagcta ccctaatcct 20
<210> 2398
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2398
taaatgagat aaactcccag 20
<210> 2399
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2399
tattgggcaa caacctgaaa 20
<210> 2400
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2400
ttttagctgc tactttcttg 20
<210> 2401
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2401
gatacataaa aaagagtaaa 20
<210> 2402
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2402
agattaaaac attatcagat 20
<210> 2403
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2403
acaactgtta gtttccttga 20
<210> 2404
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2404
tttcaaaagc atatgcagca 20
<210> 2405
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2405
cagtcgaaat ttcacaaagt 20
<210> 2406
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2406
cttaagtact gcttttaaaa 20
<210> 2407
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2407
cctcccctcc ttgggtaacc 20
<210> 2408
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2408
tcagcctttc cttccacact 20
<210> 2409
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2409
tattacacct taagaagatg 20
<210> 2410
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2410
ttacacaatt taaatgtaat 20
<210> 2411
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2411
ttagttccag aaaatactat 20
<210> 2412
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2412
ccagggtgca tagtctgtag 20
<210> 2413
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2413
cttctacaaa aaaaagtcag 20
<210> 2414
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2414
cactgaattt ctaggaaaat 20
<210> 2415
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2415
agaatactga gcaaagacaa 20
<210> 2416
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2416
gtctaacaca actccaccct 20
<210> 2417
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2417
ccaagataac aggtaataga 20
<210> 2418
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2418
cttccagact ggtgatagca 20
<210> 2419
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2419
agacacaata ttttggaaca 20
<210> 2420
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2420
gttagaaatt ttaaaagact 20
<210> 2421
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2421
ctggaatagg gtctagcagc 20
<210> 2422
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2422
aaaaatgggc ccctattaaa 20
<210> 2423
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2423
tcccttaaat atacttaaaa 20
<210> 2424
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2424
gttgttaaaa ctcattgcta 20
<210> 2425
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2425
gaccacttct caaactatta 20
<210> 2426
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2426
ctcccaaaca atctatgtca 20
<210> 2427
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2427
aaccgatcaa agtacctagc 20
<210> 2428
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2428
cacagtgaca aaattcatga 20
<210> 2429
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2429
tatctcttaa cccagagaat 20
<210> 2430
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2430
ctgggactag aagctgtgca 20
<210> 2431
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2431
acttaattac tccacagaat 20
<210> 2432
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2432
ttctctcatt tgaatatcag 20
<210> 2433
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2433
taaaaagagt taaatcccct 20
<210> 2434
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2434
tgtacaaagt atatcttttt 20
<210> 2435
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2435
attagattgt aaatatgtta 20
<210> 2436
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2436
ccaagtttct acatttctaa 20
<210> 2437
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2437
ttgttgagaa aagcacagat 20
<210> 2438
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2438
cattggcatt cattcaatcc 20
<210> 2439
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2439
ggtatctgca aggaacctca 20
<210> 2440
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2440
ttcaattgta tgagggcctg 20
<210> 2441
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2441
ttacttcctg ctcaaactga 20
<210> 2442
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2442
caggagctct gctctcaggc 20
<210> 2443
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2443
gtactactct ttctttcttt 20
<210> 2444
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2444
ttttttctga tttgatttgt 20
<210> 2445
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2445
gcatgcaatt ctatattgca 20
<210> 2446
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2446
cccacttcct tccaacaagg 20
<210> 2447
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2447
gaaaggttat tgcccaagtt 20
<210> 2448
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2448
gccacatcag catggcaaac 20
<210> 2449
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2449
taccaaagct atctaattca 20
<210> 2450
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2450
ttaaacgagg taatgtgtgt 20
<210> 2451
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2451
ttaagctttg cattgtacct 20
<210> 2452
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2452
aggacttcca cattattgca 20
<210> 2453
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2453
cttgatttaa gaaaatagtc 20
<210> 2454
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2454
ggagaatgta tatgcttctg 20
<210> 2455
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2455
ggaccactgc tgccattata 20
<210> 2456
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2456
gaatattact aagtcaaatg 20
<210> 2457
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2457
cctacactaa ttgaattaga 20
<210> 2458
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2458
tccaaatgtg tcaaactctt 20
<210> 2459
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2459
tctgattatg gctaaataag 20
<210> 2460
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2460
gttaagatgc agttcatcca 20
<210> 2461
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2461
cgtttatgat ggttttccga 20
<210> 2462
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2462
gacatgtagt tctttggaaa 20
<210> 2463
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2463
ataaggcatt tcatatagtc 20
<210> 2464
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2464
gtgagccttg gttgatctgg 20
<210> 2465
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2465
gggtttcagg tctcggtata 20
<210> 2466
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2466
caggagagta ccagactgtg 20
<210> 2467
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2467
ccagcatgac atttttaagg 20
<210> 2468
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2468
aagcattaga atgaagcaga 20
<210> 2469
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2469
gcctttacct gctgcacact 20
<210> 2470
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2470
ctctaaatta attacttaac 20
<210> 2471
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2471
tgattaaata gaatctctgg 20
<210> 2472
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2472
aaatgtacta tttaaagaca 20
<210> 2473
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2473
ggctgtccca tcactaggtc 20
<210> 2474
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2474
gttagactta tcaagctcta 20
<210> 2475
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2475
tttgatcaag ccagtaagtt 20
<210> 2476
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2476
tgtttaaaaa aaggctgttt 20
<210> 2477
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2477
attatcttag ggaaaggaca 20
<210> 2478
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2478
tgtgctactc tgacacctgg 20
<210> 2479
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2479
gtatatttgt cacaactgtt 20
<210> 2480
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2480
gctttttcaa aagcatatgc 20
<210> 2481
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2481
tgtaaccagt cctcagacac 20
<210> 2482
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2482
acataaaaag ttttaactta 20
<210> 2483
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2483
aaagtcccag tttaaacaca 20
<210> 2484
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2484
ttttctttgg gcctcagcct 20
<210> 2485
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2485
gaggctgcct attacacctt 20
<210> 2486
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2486
ttttgcatta cacaatttaa 20
<210> 2487
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2487
tggagttagg ccatatgaat 20
<210> 2488
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2488
gtccagggtg catagtctgt 20
<210> 2489
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2489
taccagtatc ttaaattcag 20
<210> 2490
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2490
agttcccaaa ttctttccaa 20
<210> 2491
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2491
aatggcaggg ctcttacatt 20
<210> 2492
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2492
gagccaccct gcatgaagct 20
<210> 2493
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2493
gcactgcatg ctggccctac 20
<210> 2494
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2494
ttatataatg tggtgaatgg 20
<210> 2495
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2495
tgacttgaga cacaatattt 20
<210> 2496
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2496
attgtgaaca aagaaaatcc 20
<210> 2497
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2497
caaatcaatc aacggttaca 20
<210> 2498
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2498
taattggagg aaattcaacc 20
<210> 2499
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2499
gaaaaaacat cccttaaata 20
<210> 2500
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2500
taaaagttgt aatattcatt 20
<210> 2501
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2501
ttcagagtct tgagtttcat 20
<210> 2502
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2502
tctttagatt gtgtaattgg 20
<210> 2503
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2503
cacttttagc atatttgtca 20
<210> 2504
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2504
aaatggaaca gaactaagct 20
<210> 2505
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2505
caaatggtta ctcaagagac 20
<210> 2506
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2506
atttcagcat agctagtgac 20
<210> 2507
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2507
ctttcatgga gtttcaactt 20
<210> 2508
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2508
tcccatgttg tgtactttat 20
<210> 2509
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2509
tgcacacaac acaagtgatt 20
<210> 2510
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2510
tctccattcc acaacatata 20
<210> 2511
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2511
atggaaagcc tctacctatt 20
<210> 2512
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2512
tggaggcagc taggagtctg 20
<210> 2513
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2513
caaaggccta aagccaatta 20
<210> 2514
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2514
aggccttcca gaccttctcg 20
<210> 2515
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2515
gatataaagc ctctggtatc 20
<210> 2516
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2516
cctgaacttt caattgtatg 20
<210> 2517
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2517
ctaaatgatt tacttcctgc 20
<210> 2518
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2518
tgccatagga cccagaatta 20
<210> 2519
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2519
cagaaagtta tcaaatatgt 20
<210> 2520
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2520
agctcgaaaa agaaattgca 20
<210> 2521
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2521
taacttgaaa agaaaatctc 20
<210> 2522
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2522
cctaatcaca ttgacaactg 20
<210> 2523
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2523
gagatgactg aagatgtgaa 20
<210> 2524
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2524
tttccctttc aacctaagac 20
<210> 2525
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2525
ctttacttga agcataaatt 20
<210> 2526
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2526
cccaaagtta caatgttaaa 20
<210> 2527
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2527
actggcatta tgaactgtta 20
<210> 2528
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2528
tgaggacttc cacattattg 20
<210> 2529
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2529
cttccagcca aaacaattta 20
<210> 2530
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2530
tcaggagaat gtatatgctt 20
<210> 2531
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2531
gcctccagct gcactggtaa 20
<210> 2532
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2532
gtaatcatcc atagctactt 20
<210> 2533
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2533
aatacggcat ctcggtaaaa 20
<210> 2534
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2534
aagtccaaat gtgtcaaact 20
<210> 2535
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2535
tgatctgatt atggctaaat 20
<210> 2536
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2536
gtctttggct ttacatccta 20
<210> 2537
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2537
ttttcaagtt ctacatagca 20
<210> 2538
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2538
tgtgacatgt agttctttgg 20
<210> 2539
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2539
gtgaaatctc aagtaatcga 20
<210> 2540
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2540
atggtgagcc ttggttgatc 20
<210> 2541
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2541
tgccgtagtc agcaatcttt 20
<210> 2542
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2542
ttttctaggg tatgtctctt 20
<210> 2543
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2543
agcaagattg tatctctttc 20
<210> 2544
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2544
aatgatgtag gatctgcagc 20
<210> 2545
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2545
aatgagttga agtgaaaaca 20
<210> 2546
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2546
tatcaacaga ttaacaaaga 20
<210> 2547
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2547
ttggtgaagc aacagtatca 20
<210> 2548
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2548
tacagatgtg ctgaaagtta 20
<210> 2549
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2549
taaaaccaat gtattgaatg 20
<210> 2550
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2550
ataactgtgt tctacttttc 20
<210> 2551
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2551
agacttaaaa atgaaagaca 20
<210> 2552
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2552
aaaatataag tcttagggac 20
<210> 2553
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2553
gtgcctaaaa aagaatgtat 20
<210> 2554
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2554
agtagcattt ccctgatcac 20
<210> 2555
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2555
aaaaaaaaac ctaatagacg 20
<210> 2556
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2556
aaatatctct aacaacaatt 20
<210> 2557
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2557
gtagccattt tttctaaaaa 20
<210> 2558
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2558
taatgattaa ggaataattt 20
<210> 2559
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2559
atcagaacca tgttctcact 20
<210> 2560
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2560
ctatcatcct ctgcaccaca 20
<210> 2561
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2561
ccctcctcca actttcagtc 20
<210> 2562
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2562
tatgtcttta ttcttaacat 20
<210> 2563
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2563
tattcagctt tctttgcttt 20
<210> 2564
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2564
gatactttta aatctaatag 20
<210> 2565
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2565
cttcttttac ctccaaaccc 20
<210> 2566
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2566
aatggtgaat aaccatgctg 20
<210> 2567
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2567
cctaaaggac cctattactt 20
<210> 2568
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2568
cagtgcccag gtggtaatga 20
<210> 2569
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2569
tctctcagtc ttcaaccttc 20
<210> 2570
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2570
atgtgcaaaa cactagtatc 20
<210> 2571
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2571
attgtcagga agcaaatgat 20
<210> 2572
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2572
tgaaaaatat gaatacctca 20
<210> 2573
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2573
acaatttaac ttaccaagga 20
<210> 2574
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2574
gatgaaactg gcaccaagaa 20
<210> 2575
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2575
gtgggtcacc tttctttctt 20
<210> 2576
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2576
atcaaagagg actcattaat 20
<210> 2577
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2577
caaatctacc gtttctagga 20
<210> 2578
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2578
gttaactagt tgctatatga 20
<210> 2579
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2579
actcggaaag tttcccaatt 20
<210> 2580
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2580
gaataggaaa gtctacaaat 20
<210> 2581
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2581
taatatccag agtgccgtta 20
<210> 2582
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2582
cttaactaaa cccaaattct 20
<210> 2583
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2583
tcagacaagt tgctcttggt 20
<210> 2584
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2584
aagaggtttg tatttaattt 20
<210> 2585
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2585
cacttcataa gtattgaagg 20
<210> 2586
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2586
aatagttctc accacataaa 20
<210> 2587
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2587
tctcatatag tgccttgaaa 20
<210> 2588
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2588
agtcatgttc aataaaaata 20
<210> 2589
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2589
aggtgggaat attctaagta 20
<210> 2590
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2590
ctacaaaagt ttaccgagga 20
<210> 2591
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2591
gaaagattca gataatcctt 20
<210> 2592
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2592
ataatttctc acaagactta 20
<210> 2593
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2593
gtaattttac ttacaaataa 20
<210> 2594
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2594
taagagaaat ttatgaatta 20
<210> 2595
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2595
aacctaaaga catccaatca 20
<210> 2596
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2596
caacaggacc aaataggaat 20
<210> 2597
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2597
gggaccctga gctaagacat 20
<210> 2598
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2598
aaatggcctt aatgttctcc 20
<210> 2599
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2599
tttgtgactc aaagctaata 20
<210> 2600
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2600
ccattttccc cttttaaaca 20
<210> 2601
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2601
aagaccatcc atatgacact 20
<210> 2602
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2602
aacagcttaa cctttctata 20
<210> 2603
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2603
gaggagatct aaggtcttca 20
<210> 2604
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2604
atgaggactt ccacattatt 20
<210> 2605
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2605
acaggcttcc agccaaaaca 20
<210> 2606
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2606
ttcaggagaa tgtatatgct 20
<210> 2607
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2607
ataaaatgta aaatagctcg 20
<210> 2608
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2608
attctgatca cacgctctct 20
<210> 2609
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2609
gtaatacggc atctcggtaa 20
<210> 2610
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2610
caagtccaaa tgtgtcaaac 20
<210> 2611
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2611
ctgatctgat tatggctaaa 20
<210> 2612
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2612
ttttaccact cccagtattt 20
<210> 2613
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2613
cacattttta cgctccgata 20
<210> 2614
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2614
ctgtgacatg tagttctttg 20
<210> 2615
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2615
cttcaggaga ccaatttaag 20
<210> 2616
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2616
aatggtgagc cttggttgat 20
<210> 2617
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2617
gccctctgat gtttttatcc 20
<210> 2618
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2618
tcatcttttc tagggtatgt 20
<210> 2619
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2619
tttcagctaa ttcttttctc 20
<210> 2620
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2620
gaaaagtgtt agatatttat 20
<210> 2621
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2621
gaatgagttg aagtgaaaac 20
<210> 2622
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2622
atccagtaat ctcatcgctg 20
<210> 2623
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2623
attctgaaca gcttctggtg 20
<210> 2624
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2624
ttttcctgga aacacattct 20
<210> 2625
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2625
aagggcagga atgaccacta 20
<210> 2626
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2626
gcaattgaag aaagtctact 20
<210> 2627
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2627
gtttctccag caccaagccc 20
<210> 2628
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2628
ttccagaagg gcaaccaatg 20
<210> 2629
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2629
gaactggaca agttaatcct 20
<210> 2630
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2630
tgctgttcta gacaatttgg 20
<210> 2631
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2631
aagccttggt caattataaa 20
<210> 2632
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2632
cacttgccat tatcaaatat 20
<210> 2633
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2633
tgtatgcaac cttgggacct 20
<210> 2634
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2634
tggaaagcat ttacatagaa 20
<210> 2635
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2635
tgttaactga aacttgtgca 20
<210> 2636
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2636
tctatcatcc tctgcaccac 20
<210> 2637
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2637
taaggaaggc agccttgata 20
<210> 2638
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2638
tttataaaaa tgttcacact 20
<210> 2639
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2639
aatctcatcc atctgtaatt 20
<210> 2640
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2640
tactctgatt tcctcatctt 20
<210> 2641
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2641
ctttacaatg tcttctttta 20
<210> 2642
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2642
ataaatggtg aataaccatg 20
<210> 2643
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2643
tggataacac ctaaaggacc 20
<210> 2644
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2644
gtatttggag cagtgcccag 20
<210> 2645
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2645
gtaccttaac acagtaaata 20
<210> 2646
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2646
taatctacta tgtgcaaaac 20
<210> 2647
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2647
tctacattgt caggaagcaa 20
<210> 2648
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2648
atctctcaca gatgcaaaat 20
<210> 2649
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2649
ataatcacaa ttgcacaatt 20
<210> 2650
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2650
gaatcattag gtaaatatat 20
<210> 2651
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2651
agtggagaag agagaaagac 20
<210> 2652
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2652
tatcaaaaac aatttgcttt 20
<210> 2653
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2653
acagtctctt ttcttatctg 20
<210> 2654
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2654
tttagtgtca attctaaaaa 20
<210> 2655
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2655
cagtagctat aatgctttaa 20
<210> 2656
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2656
tttagatttc atttaagaaa 20
<210> 2657
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2657
aattacatgt ccaacaagag 20
<210> 2658
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2658
aataaaagta tcttccaaac 20
<210> 2659
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2659
aaattcacaa aagtttctgc 20
<210> 2660
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2660
tttcatatct cttttatcat 20
<210> 2661
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2661
ttttgctttg tcaaattcac 20
<210> 2662
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2662
ctataattga atatactatt 20
<210> 2663
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2663
attaaatcaa tctaatgcat 20
<210> 2664
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2664
ctcaatcccc aaggagtttg 20
<210> 2665
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2665
ctttcaccct gaacacacag 20
<210> 2666
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2666
ctcaaccctc acccatgcag 20
<210> 2667
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2667
cctgcttata atctctggtt 20
<210> 2668
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2668
tctgaaggct tactatttta 20
<210> 2669
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2669
actacagcat ttcatgtgat 20
<210> 2670
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2670
atgtatagcc acctgtaatt 20
<210> 2671
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2671
cttggataat tatcataatg 20
<210> 2672
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2672
tctcttgggt tcatgcctga 20
<210> 2673
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2673
taaatatttt tgtagctcta 20
<210> 2674
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2674
tgtttctagg gaccctgagc 20
<210> 2675
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2675
aaatgttgaa attgttacaa 20
<210> 2676
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2676
aaatgacaat taggagggtc 20
<210> 2677
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2677
cttgcaaaac tttgtttcat 20
<210> 2678
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2678
aatttatacc agtcttatgt 20
<210> 2679
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2679
attcttaatt atgtgagtct 20
<210> 2680
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2680
attttacctg aagttaggag 20
<210> 2681
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2681
catgaggact tccacattat 20
<210> 2682
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2682
ttatttagtg cccagcatgc 20
<210> 2683
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2683
cttcaggaga atgtatatgc 20
<210> 2684
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2684
attctgtatc ctccctggat 20
<210> 2685
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2685
ctgttattct gatcacacgc 20
<210> 2686
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2686
tgtaatacgg catctcggta 20
<210> 2687
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2687
gcaagtccaa atgtgtcaaa 20
<210> 2688
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2688
gctgatctga ttatggctaa 20
<210> 2689
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2689
ggtggtttta ccactcccag 20
<210> 2690
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2690
ggcacatttt tacgctccga 20
<210> 2691
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2691
tactgtgaca tgtagttctt 20
<210> 2692
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2692
ataagcttca ggagaccaat 20
<210> 2693
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2693
ggaatggtga gccttggttg 20
<210> 2694
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2694
catttcctct ggcaacttca 20
<210> 2695
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2695
aattgcaata caaacaagtg 20
<210> 2696
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2696
ataattttcc tatccaaaga 20
<210> 2697
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2697
caactgaaaa gtgttagata 20
<210> 2698
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2698
atacttggaa tagtcaagtc 20
<210> 2699
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2699
tagcacagcc atgatgaaac 20
<210> 2700
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2700
ttggatcttt tccagattaa 20
<210> 2701
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2701
aaaagattta aagttaatga 20
<210> 2702
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2702
acttcagtgt ttgtcactta 20
<210> 2703
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2703
aatttctatg atttctggtg 20
<210> 2704
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2704
actgagctac ttttgtcttc 20
<210> 2705
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2705
ttggagaatg acttttgcat 20
<210> 2706
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2706
tgcatttctt tatgaaaaca 20
<210> 2707
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2707
aaagttacat atgacatgac 20
<210> 2708
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2708
agaagccttg gtcaattata 20
<210> 2709
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2709
taactatctc aaattctcac 20
<210> 2710
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2710
gatgtctaac atatcatatt 20
<210> 2711
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2711
tcactcagct ttttgggagt 20
<210> 2712
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2712
ttgactagaa tgcagtaggt 20
<210> 2713
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2713
tgtatctagt ctctctccct 20
<210> 2714
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2714
ataatgtttt ccaaacctaa 20
<210> 2715
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2715
ccattaatta ttttaaatag 20
<210> 2716
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2716
aaatttccct ccaacaaggt 20
<210> 2717
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2717
atattagaag tgcaaatact 20
<210> 2718
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2718
ctttaaaatc attcctttac 20
<210> 2719
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2719
ttagcacatt ctctgaactt 20
<210> 2720
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2720
aagattagac tggataacac 20
<210> 2721
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2721
acatttaaat aataatgaag 20
<210> 2722
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2722
atcaatgtca gaatagcatg 20
<210> 2723
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2723
tgccaaattg tcctcaaaag 20
<210> 2724
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2724
ctagagaaaa cattaatcta 20
<210> 2725
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2725
aaaatacctt tacacaaatt 20
<210> 2726
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2726
ttgttcctag ctttggcata 20
<210> 2727
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2727
atggaaggaa tcattaggta 20
<210> 2728
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2728
gtatttagca aggcaaagaa 20
<210> 2729
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2729
aaattgcata aattcatatg 20
<210> 2730
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2730
ctgtgaaaca caatttggga 20
<210> 2731
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2731
acatgatgtc agtagctata 20
<210> 2732
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2732
ttcacactaa atggcccctg 20
<210> 2733
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2733
taattggatg aataaatttt 20
<210> 2734
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2734
taagaggata gtttctacaa 20
<210> 2735
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2735
tggcttgaaa accaagtcat 20
<210> 2736
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2736
tctttcatat ctcttttatc 20
<210> 2737
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2737
tgatccttgt catggcagtt 20
<210> 2738
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2738
aatcaacatt ttctgaatct 20
<210> 2739
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2739
tttatattaa atcaatctaa 20
<210> 2740
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2740
aagagctctg ctactccatc 20
<210> 2741
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2741
taaagaactt gagaaggtga 20
<210> 2742
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2742
ccactgttaa ctaacagtgt 20
<210> 2743
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2743
ctatagccac tactaatcag 20
<210> 2744
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2744
attctgaagg cttactattt 20
<210> 2745
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2745
ttctctgccc catgatgtca 20
<210> 2746
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2746
ggtgatttaa ttgagttgca 20
<210> 2747
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2747
taaatgttca atgtattgtt 20
<210> 2748
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2748
gagagatgag tagaaaggag 20
<210> 2749
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2749
gcacattatc tttaataaat 20
<210> 2750
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2750
ataacccatc tcaggctctg 20
<210> 2751
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2751
ctactgtgtt caagatttta 20
<210> 2752
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2752
agcacagatg gcaaaaagct 20
<210> 2753
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2753
gaaatattat atctgtaact 20
<210> 2754
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2754
aatctgcttc tcttgtggga 20
<210> 2755
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2755
caaatacctt ggaactgaat 20
<210> 2756
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2756
tctcaacaaa ttcagtcagt 20
<210> 2757
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2757
ccactcatga ggacttccac 20
<210> 2758
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2758
aggagattat ttagtgccca 20
<210> 2759
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2759
gccacttcag gagaatgtat 20
<210> 2760
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2760
atatttagct tatgatgaaa 20
<210> 2761
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2761
acctttccca atgcttatcg 20
<210> 2762
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2762
gcaaatttgg tgagcaacgc 20
<210> 2763
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2763
atcaagatta gcaatacaac 20
<210> 2764
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2764
caagatgctg atctgattat 20
<210> 2765
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2765
tatagaattc ctcacgacct 20
<210> 2766
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2766
caattggcac atttttacgc 20
<210> 2767
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2767
taaaatactg tgacatgtag 20
<210> 2768
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2768
ccacaacttg gcccaaaaga 20
<210> 2769
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2769
gtcagccaaa atcaagtcag 20
<210> 2770
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2770
ggtaattttc cttgtatttc 20
<210> 2771
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2771
ggagtactga catttcctat 20
<210> 2772
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2772
ataagaaata taacattgtg 20
<210> 2773
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2773
cctcaaatta ttacataggt 20
<210> 2774
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2774
taagacatca ctttctttag 20
<210> 2775
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2775
gaatcaaata ttggctgtgc 20
<210> 2776
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2776
catatatgta ccctctagag 20
<210> 2777
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2777
ctgatacata gaattacaga 20
<210> 2778
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2778
gccaaagttt tctcagggaa 20
<210> 2779
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2779
gggcccacat aaatcattct 20
<210> 2780
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2780
ctctccactc catgtctctg 20
<210> 2781
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2781
acaataatgt aacatatttt 20
<210> 2782
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2782
agcaaacatt taaaagccca 20
<210> 2783
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2783
cataattaga ttacatagtt 20
<210> 2784
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2784
tttatgagag tcctacctgc 20
<210> 2785
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2785
tagaagtccg gaaaaatata 20
<210> 2786
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2786
tcttactcaa tagtcacctt 20
<210> 2787
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2787
ttagaatatt aatatagtcc 20
<210> 2788
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2788
actgatctga ttcaatggta 20
<210> 2789
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2789
cagaacaaag tatcatccct 20
<210> 2790
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2790
ctttattaag ctacactgta 20
<210> 2791
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2791
agataaattt aacccattac 20
<210> 2792
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2792
acgaatcatg ccacagtgaa 20
<210> 2793
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2793
tactagaaca cagtgaaatg 20
<210> 2794
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2794
aatacatagt ctcccttgac 20
<210> 2795
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2795
attcttaatc tcccgtgaac 20
<210> 2796
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2796
catggttcag gagggaagag 20
<210> 2797
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2797
tccttggagg atccaaacta 20
<210> 2798
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2798
tcataaagaa cttaaatgtc 20
<210> 2799
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2799
atgggaaatt atcccgaagc 20
<210> 2800
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2800
caaaatactt caacacttca 20
<210> 2801
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2801
aatataacaa aaatctgatt 20
<210> 2802
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2802
aacccacacc attaggtaga 20
<210> 2803
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2803
tgcaaaaacc agaggcacgg 20
<210> 2804
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2804
ttttaaatca aattggatga 20
<210> 2805
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2805
cccctctata gtatacaaaa 20
<210> 2806
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2806
ttaacctgga agctaaacag 20
<210> 2807
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2807
tgagaggtga tgacagagct 20
<210> 2808
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2808
tgcacagaag agttcattgc 20
<210> 2809
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2809
taaaaagttg tcttcaaagg 20
<210> 2810
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2810
cttggttatt tgtaaaatgt 20
<210> 2811
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2811
ttatgtcaaa gctacagaga 20
<210> 2812
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2812
ttttccaaat tcctttgtat 20
<210> 2813
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2813
gaaacaatga acatcagtat 20
<210> 2814
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2814
aactgctgca gactaccaga 20
<210> 2815
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2815
agcatttaaa ttcaacctaa 20
<210> 2816
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2816
gtaaggttga gaacaagtgc 20
<210> 2817
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2817
agtagattct gttatacaaa 20
<210> 2818
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2818
aaaagagatt atgtcagatt 20
<210> 2819
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2819
gtactgtcag aattaaattt 20
<210> 2820
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2820
gatttgttat ttaaagtaag 20
<210> 2821
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2821
acagtgtaaa gttttcatct 20
<210> 2822
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2822
gagttgcata tggtttagga 20
<210> 2823
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2823
ttctcatcca gtgcacacat 20
<210> 2824
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2824
cctgaaagta agcagataaa 20
<210> 2825
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2825
aattcatgcc attccagaat 20
<210> 2826
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2826
ataagaagat tgttcctctc 20
<210> 2827
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2827
agagaaataa atgctcatgg 20
<210> 2828
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2828
tatggaactt taaagagtta 20
<210> 2829
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2829
actttactta cttttggtta 20
<210> 2830
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2830
agactatgat taaaacaaac 20
<210> 2831
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2831
acatcattgc cctgtttgga 20
<210> 2832
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2832
tttgttctca acaaattcag 20
<210> 2833
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2833
gccactcatg aggacttcca 20
<210> 2834
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2834
aaggagatta tttagtgccc 20
<210> 2835
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2835
cagccacttc aggagaatgt 20
<210> 2836
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2836
catatttagc ttatgatgaa 20
<210> 2837
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2837
cacctttccc aatgcttatc 20
<210> 2838
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2838
ttcatgatca aaaatgggcc 20
<210> 2839
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2839
atctaaaacc actgagggtc 20
<210> 2840
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2840
accataaata tgctttttca 20
<210> 2841
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2841
actatagaat tcctcacgac 20
<210> 2842
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2842
tcaattggca catttttacg 20
<210> 2843
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2843
tttttctagg agcttaaaat 20
<210> 2844
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2844
tccacaactt ggcccaaaag 20
<210> 2845
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2845
ggtcagccaa aatcaagtca 20
<210> 2846
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2846
atttctttcc gttgaatttg 20
<210> 2847
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2847
atcggcctta taaattttag 20
<210> 2848
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2848
aagaatttac cgaaagtact 20
<210> 2849
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2849
aaatttctgg gtttcctatg 20
<210> 2850
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2850
agctctttga tcctcagtga 20
<210> 2851
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2851
aaaaagagaa agtgcatata 20
<210> 2852
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2852
tgtacaggaa tatgactaga 20
<210> 2853
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2853
tccagcctct ctcatgctat 20
<210> 2854
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2854
tgataactga cacagggccc 20
<210> 2855
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2855
ggcccttcat gctctccact 20
<210> 2856
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2856
agataaataa attggagggt 20
<210> 2857
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2857
atatttttaa gcccacattg 20
<210> 2858
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2858
tcatcaacgg cctcacaatc 20
<210> 2859
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2859
aattttgaat aactctaata 20
<210> 2860
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2860
atgtcatgtg tgagtttaca 20
<210> 2861
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2861
ggtcttactc aatagtcacc 20
<210> 2862
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2862
acttatagat atgaaagcat 20
<210> 2863
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2863
aaagatttac atttagtcga 20
<210> 2864
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2864
atataactag agaaaatgat 20
<210> 2865
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2865
aagttctgta aaggctatat 20
<210> 2866
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2866
aaagaaaaga accaaggttt 20
<210> 2867
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2867
gcatttagtt tgttgccaca 20
<210> 2868
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2868
ctaataaagt ggatggattt 20
<210> 2869
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2869
tatcatctta ataatacata 20
<210> 2870
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2870
ctcttgaaga aaaactattt 20
<210> 2871
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2871
agaacaatca gatagatata 20
<210> 2872
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2872
tttgtggaag gaattttcct 20
<210> 2873
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2873
gtaccccttc aaaaagcttc 20
<210> 2874
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2874
cactataccc atatacccaa 20
<210> 2875
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2875
gaaaactgca tttcaccaag 20
<210> 2876
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2876
ttatccagaa aatctccaaa 20
<210> 2877
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2877
tccatagttc caaaacagac 20
<210> 2878
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2878
caaagatgct cctgaacatc 20
<210> 2879
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2879
cactgggaat agacagaaac 20
<210> 2880
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2880
ggttttgaca agtgtaccat 20
<210> 2881
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2881
accaatagtg tgtcacttaa 20
<210> 2882
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2882
actagcatta ttgacatatg 20
<210> 2883
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2883
tagtgagtga acacagccat 20
<210> 2884
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2884
tcctgacaca agctttttaa 20
<210> 2885
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2885
ctggtatttc tcaaagcatt 20
<210> 2886
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2886
ttttaaatat tcaaggtaaa 20
<210> 2887
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2887
aatgtgcaac aaagaattat 20
<210> 2888
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2888
cattatcttg actttatcac 20
<210> 2889
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2889
tagcaattaa ttttttaagg 20
<210> 2890
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2890
agaagtaata aaacattttt 20
<210> 2891
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2891
gggagagtaa tcacaaacat 20
<210> 2892
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2892
tctcctgttc agaaacaaat 20
<210> 2893
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2893
gtttagagca gtaagtcatg 20
<210> 2894
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2894
taaaatttga aatgcatgct 20
<210> 2895
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2895
tacttaacga agattaaata 20
<210> 2896
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2896
caaatgcata cttgctttcg 20
<210> 2897
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2897
aacagtgtaa agttttcatc 20
<210> 2898
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2898
agagttgcat atggtttagg 20
<210> 2899
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2899
ttctaaattc tcatccagtg 20
<210> 2900
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2900
atgatcatct gtttaaggaa 20
<210> 2901
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2901
agcataaaca agaaggagaa 20
<210> 2902
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2902
agttttgcct atcaagatga 20
<210> 2903
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2903
cctaagcacc catgaatgaa 20
<210> 2904
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2904
aatctctttt gggagatgag 20
<210> 2905
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2905
taaccattct gaattgaata 20
<210> 2906
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2906
aattattatc aaaggaagac 20
<210> 2907
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2907
aatttatgaa acacataata 20
<210> 2908
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2908
acctgctgca cactcgcgac 20
<210> 2909
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2909
acttccacat tattgcaagg 20
<210> 2910
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2910
cgctgagatc tgcaatgctg 20
<210> 2911
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2911
agaatgtata tgcttctgca 20
<210> 2912
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2912
agcattttac agccactttc 20
<210> 2913
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2913
aagatgctga caatttgagg 20
<210> 2914
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2914
atttagacag cacatcttca 20
<210> 2915
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2915
caaatgtgtc aaactcttca 20
<210> 2916
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2916
cagtgtgcgg gacctggtag 20
<210> 2917
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2917
atttccccat ttcattggga 20
<210> 2918
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2918
cgaagttttg ccaaagcatc 20
<210> 2919
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2919
ttttggacaa ccttccactt 20
<210> 2920
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2920
aaggcatttc atatagtcgg 20
<210> 2921
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2921
gagccttggt tgatctggat 20
<210> 2922
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2922
tggctgagtg gaggtatctc 20
<210> 2923
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2923
tttcaacagg aagatgcacc 20
<210> 2924
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2924
agctgtgctg tcatcatgac 20
<210> 2925
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2925
aaaaatatca cttgaaggac 20
<210> 2926
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2926
tttacctgct gcacactcgc 20
<210> 2927
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2927
tatacatgta tcaaatagca 20
<210> 2928
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2928
atctctctaa gagagaaggt 20
<210> 2929
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2929
tctcttcatg gtttgaattc 20
<210> 2930
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2930
aagtttgctt atttgcattt 20
<210> 2931
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2931
taatttcatg agtctcaatc 20
<210> 2932
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2932
catgtataaa attatagttt 20
<210> 2933
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2933
caatgtgggt ggaaaacaat 20
<210> 2934
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2934
atagacaatg acccttgctc 20
<210> 2935
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2935
ttctcatgaa aaataatgaa 20
<210> 2936
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2936
tgagctacac aggacagaaa 20
<210> 2937
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2937
caaaagcata tgcagcagag 20
<210> 2938
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2938
atcaaaggag atttccaggt 20
<210> 2939
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2939
aataagtagt ctatcttaag 20
<210> 2940
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2940
tccgctgtgt ttttgcctca 20
<210> 2941
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2941
atgcctcact cacccccgac 20
<210> 2942
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2942
aagaagatgt gaccactaaa 20
<210> 2943
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2943
gtaattccct tcttctcttt 20
<210> 2944
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2944
aatactattg ttatttttac 20
<210> 2945
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2945
cagggtgcat agtctgtagg 20
<210> 2946
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2946
tctgaacttt ctgtttgatt 20
<210> 2947
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2947
gccctacaaa aatctattct 20
<210> 2948
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2948
ggatgcaagt gaaaaacact 20
<210> 2949
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2949
ctagatataa ataacctctg 20
<210> 2950
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2950
ataatatcca tcagttactg 20
<210> 2951
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2951
gaagagacag ccaggtgaag 20
<210> 2952
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2952
acaatatttt ggaacaactc 20
<210> 2953
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2953
ataggtaata tgatttaatt 20
<210> 2954
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2954
tcatgtttca tggtttcttt 20
<210> 2955
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2955
ggaaggaacc atgaaatttt 20
<210> 2956
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2956
ccttgagaat ttaacaattt 20
<210> 2957
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2957
ctctttctta cccttctaaa 20
<210> 2958
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2958
gcaaagcaaa cagattttga 20
<210> 2959
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2959
tcactcatct gtaatattaa 20
<210> 2960
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2960
ctaacatatc cctccatgtt 20
<210> 2961
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2961
ccataaaaca ggaattccaa 20
<210> 2962
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2962
atctcttaac ccagagaatt 20
<210> 2963
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2963
atatttgaga cactgacatg 20
<210> 2964
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2964
aattactcca cagaatcttc 20
<210> 2965
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2965
aattctaact ctacctcttc 20
<210> 2966
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2966
taaaaagaag tttttgatca 20
<210> 2967
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2967
atgtgcagga agtcaagata 20
<210> 2968
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2968
gtattatttg catcttatca 20
<210> 2969
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2969
agtgagtctt acaaaaagtt 20
<210> 2970
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2970
gagaaaagca cagatgactc 20
<210> 2971
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2971
ctctgcaatt caaaaaaagt 20
<210> 2972
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2972
taggcaatga gagatgatac 20
<210> 2973
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2973
cagctgaaga ttctctctct 20
<210> 2974
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2974
tcaggattgg gaactaagaa 20
<210> 2975
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2975
ttctctaaac tttagtctct 20
<210> 2976
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2976
tactctttca actgttcttt 20
<210> 2977
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2977
ggatggtgaa aattatagga 20
<210> 2978
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2978
ttctatattg cagagccacc 20
<210> 2979
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2979
ttcagtggag tttagttcag 20
<210> 2980
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2980
ccaagttcac aaaaccaata 20
<210> 2981
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2981
atggcaaact cctacttggc 20
<210> 2982
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2982
ttttcccaga accagtgaat 20
<210> 2983
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2983
tttggatatg gtaaggtaca 20
<210> 2984
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2984
tgctgcacac tcgcgactct 20
<210> 2985
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2985
tcgctaggga atgtaaacaa 20
<210> 2986
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2986
ctttcatagc ttccaccaca 20
<210> 2987
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2987
gcattaactc caaaacattc 20
<210> 2988
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2988
acagccactt tcagccactt 20
<210> 2989
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2989
cattcttctt tgtaatcaag 20
<210> 2990
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2990
gctagtgtag atgctatatt 20
<210> 2991
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2991
gtcaaactct tcagagtttc 20
<210> 2992
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2992
ggaaaatttg ttctgagata 20
<210> 2993
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2993
atccagagat gtcagatttt 20
<210> 2994
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2994
gcgcgagcct ttatattgaa 20
<210> 2995
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2995
catttcatat agtcggatga 20
<210> 2996
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2996
ttgatgttct tcaccatcat 20
<210> 2997
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2997
tgctgaagca ggcgatccaa 20
<210> 2998
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2998
tcaagaaatg agagctgtcc 20
<210> 2999
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 2999
tcctccagtt cctatccaaa 20
<210> 3000
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3000
atgtctagga aagacacaga 20
<210> 3001
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3001
atttaaatat ggtattcatt 20
<210> 3002
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3002
actcataact actccggaca 20
<210> 3003
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3003
tggcagtctg gaatatcatg 20
<210> 3004
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3004
aatcaaactt ctgagtttaa 20
<210> 3005
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3005
agcactactt attttccaat 20
<210> 3006
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3006
aggcaccttc attcctattg 20
<210> 3007
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3007
ttttaatttt atgccagagt 20
<210> 3008
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3008
ttgtgatttt ataaacatca 20
<210> 3009
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3009
ttaaccctta tttatatatg 20
<210> 3010
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3010
ttatatacat ctgtgtataa 20
<210> 3011
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3011
ttaacatata acactattta 20
<210> 3012
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3012
cagaggatac ccattgcaaa 20
<210> 3013
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3013
cctctttaac tgcacagtag 20
<210> 3014
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3014
aacctttccc aaagtggcta 20
<210> 3015
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3015
taaccctact tcttacaagt 20
<210> 3016
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3016
catcgatatt ctcaaagcct 20
<210> 3017
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3017
tacttaaaat acttcaaaca 20
<210> 3018
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3018
accatatact atgagaccag 20
<210> 3019
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3019
ggaattacag tggagaggtt 20
<210> 3020
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3020
gtgcatagtc tgtaggtagt 20
<210> 3021
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3021
gctctgttgt cacccttgta 20
<210> 3022
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3022
cattagaaga tgaattcact 20
<210> 3023
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3023
ataatattga acagtaggtt 20
<210> 3024
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3024
ctgttgggta gaaagatttg 20
<210> 3025
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3025
ggttggaagg caccaattaa 20
<210> 3026
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3026
agcctactga gcggttggaa 20
<210> 3027
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3027
gttgcagaca ttttacatac 20
<210> 3028
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3028
tagaaccata cctaaatagt 20
<210> 3029
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3029
gtaatacccg aaagaaggga 20
<210> 3030
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3030
tgaaaaagct atatccatat 20
<210> 3031
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3031
aaaaaaaact ttcagtaatc 20
<210> 3032
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3032
aacacaatcc acaacagaat 20
<210> 3033
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3033
aggaggaaaa tactatccaa 20
<210> 3034
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3034
tatatgcaca gttttgctga 20
<210> 3035
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3035
agaacagaaa gctcagtttt 20
<210> 3036
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3036
ctctcagaaa cattttctca 20
<210> 3037
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3037
aacaaaactt aaaagtgtct 20
<210> 3038
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3038
aaacaactca cacatttcta 20
<210> 3039
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3039
agttgagtta cctcctgata 20
<210> 3040
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3040
tctggttact agaatgtagc 20
<210> 3041
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3041
gattgcctac tccaaggttt 20
<210> 3042
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3042
aggcttttaa tgaatatttc 20
<210> 3043
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3043
ggtattgaga gagcttcaga 20
<210> 3044
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3044
gaaaagacaa actaggattg 20
<210> 3045
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3045
gtagaacaga gtctgaagta 20
<210> 3046
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3046
ctgtaactct gttgaaatgt 20
<210> 3047
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3047
tcaaagacca cagcctttcc 20
<210> 3048
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3048
gctaagagac ttctttcttc 20
<210> 3049
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3049
actaaagttt ttgctgttac 20
<210> 3050
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3050
cggaaaagac aagaagataa 20
<210> 3051
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3051
ttatcatgtg aattagcata 20
<210> 3052
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3052
ccagacattg caaagaaaaa 20
<210> 3053
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3053
agtgtgaagg caccgtaaga 20
<210> 3054
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3054
ccaattccat ccattgaaat 20
<210> 3055
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3055
aaaagtgatt aggttgagtg 20
<210> 3056
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3056
tattttctac atacccctcg 20
<210> 3057
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3057
atctaaaatg ttctcaagag 20
<210> 3058
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3058
gttggcttct cagaggtttt 20
<210> 3059
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3059
gaggacttcc acattattgc 20
<210> 3060
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3060
tctcattctt ttcctctaaa 20
<210> 3061
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3061
caggagaatg tatatgcttc 20
<210> 3062
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3062
cgtttcataa ctgttagtat 20
<210> 3063
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3063
catccatagc tacttttgca 20
<210> 3064
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3064
attctcctac actaattgaa 20
<210> 3065
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3065
gtccaaatgt gtcaaactct 20
<210> 3066
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3066
atctgattat ggctaaataa 20
<210> 3067
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3067
tggctttaca tcctatatgt 20
<210> 3068
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3068
aagttctaca tagcagtctg 20
<210> 3069
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3069
gtgacatgta gttctttgga 20
<210> 3070
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3070
aaataaggca tttcatatag 20
<210> 3071
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3071
tggtgagcct tggttgatct 20
<210> 3072
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3072
tagtcagcaa tctttgcaat 20
<210> 3073
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3073
atgaccagga gagtaccaga 20
<210> 3074
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3074
ttttccggtt gtagcccaat 20
<210> 3075
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3075
tgtaggatct gcagcatcac 20
<210> 3076
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3076
acaatgcctt tacctgctgc 20
<210> 3077
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3077
tacttcagcc caggattgca 20
<210> 3078
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3078
ctacatggaa cttctgtgat 20
<210> 3079
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3079
cagatgtgct gaaagttaat 20
<210> 3080
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3080
atgagatttt tgagaggcaa 20
<210> 3081
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3081
aatttttaca tgaagactgt 20
<210> 3082
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3082
ctagagaaaa ctgacagtga 20
<210> 3083
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3083
aaagactcta ccagaaaaag 20
<210> 3084
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3084
aatgtatggt gacttgacct 20
<210> 3085
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3085
aacaaaacca cttcttcttc 20
<210> 3086
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3086
tgaagagaaa accacacact 20
<210> 3087
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3087
ttatagttca ttttttaaga 20
<210> 3088
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3088
actccaaaga caatacaaaa 20
<210> 3089
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3089
caactggcca attttcctct 20
<210> 3090
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3090
gatacattcc ttcttttcca 20
<210> 3091
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3091
ccttttcttt gggcctcagc 20
<210> 3092
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3092
acttctgagg ctgcctatta 20
<210> 3093
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3093
ccaattcatc ttatgcaaaa 20
<210> 3094
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3094
atttcctgag ccacccttct 20
<210> 3095
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3095
attaagtact tgtccagggt 20
<210> 3096
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3096
gacacagaga gctgtgagca 20
<210> 3097
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3097
gaataaccat gctgacttta 20
<210> 3098
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3098
aagacacaaa caattgcaat 20
<210> 3099
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3099
tgatagaagt gtttggtttt 20
<210> 3100
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3100
ggttagcatg tgaggtgcca 20
<210> 3101
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3101
aaggttacaa ccatgaacaa 20
<210> 3102
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3102
atattgcata acttaatagc 20
<210> 3103
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3103
agagcatttt tcaacaccta 20
<210> 3104
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3104
atagtccagc aggaaaaagc 20
<210> 3105
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3105
tgaataattg gaggaaattc 20
<210> 3106
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3106
ctctgtctcc agatataaaa 20
<210> 3107
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3107
aattagttgt aaaaatgtaa 20
<210> 3108
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3108
caggacactc ctagaagctg 20
<210> 3109
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3109
tgctatatga aatacagtgt 20
<210> 3110
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3110
gaccatgttt agagaactat 20
<210> 3111
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3111
ttacatgaca ttaccatcta 20
<210> 3112
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3112
cagaatttct gcttaaattc 20
<210> 3113
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3113
gaaacatgga atctagaaca 20
<210> 3114
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3114
caaattaact taatttttac 20
<210> 3115
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3115
gcccaaggac ttgtcttacc 20
<210> 3116
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3116
gtatcaaaac ataccttcct 20
<210> 3117
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3117
ttctcaccac ataaatattt 20
<210> 3118
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3118
ccttgaaatg tagtcacttg 20
<210> 3119
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3119
acagaaggcg aagtcaggag 20
<210> 3120
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3120
ggccacagtg atcagtttgg 20
<210> 3121
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3121
aaaaaataca tatcatcccc 20
<210> 3122
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3122
ataatccttt ataataagta 20
<210> 3123
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3123
cacaagactt aatggagtta 20
<210> 3124
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3124
aacaaatgcc aacccctaaa 20
<210> 3125
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3125
tatagtattt atatgggtgt 20
<210> 3126
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3126
acaaagggaa atggttaaac 20
<210> 3127
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3127
acgggcaccc tacaagaaat 20
<210> 3128
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3128
agtaactttc caaatggtat 20
<210> 3129
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3129
ctctgcccct tttcccagac 20
<210> 3130
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3130
ttaccaggtg ctggtcatta 20
<210> 3131
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3131
ataaagaaaa attacgaaca 20
<210> 3132
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3132
tttaccatta cctccctaga 20
<210> 3133
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3133
cagcttaacc tttctataaa 20
<210> 3134
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3134
tgattttacc tgaagttagg 20
<210> 3135
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3135
tcatgaggac ttccacatta 20
<210> 3136
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3136
gattatttag tgcccagcat 20
<210> 3137
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3137
acttcaggag aatgtatatg 20
<210> 3138
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3138
atgaaattct gtatcctccc 20
<210> 3139
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3139
gcatctgctc ccaatagaag 20
<210> 3140
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3140
ctgtaatacg gcatctcggt 20
<210> 3141
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3141
gtgcaagtcc aaatgtgtca 20
<210> 3142
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3142
atgctgatct gattatggct 20
<210> 3143
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3143
tggcacattt ttacgctccg 20
<210> 3144
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3144
atactgtgac atgtagttct 20
<210> 3145
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3145
agaatacagc cttttctaca 20
<210> 3146
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3146
tggaatggtg agccttggtt 20
<210> 3147
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3147
aatgacattt cctctggcaa 20
<210> 3148
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3148
ttgcttggaa aaggaattgc 20
<210> 3149
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3149
aataaatatt tacaagagga 20
<210> 3150
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3150
gctatgtaaa caatttaagt 20
<210> 3151
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3151
attgggaaga tacttggaat 20
<210> 3152
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3152
acacaaatca tttcaaaatg 20
<210> 3153
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3153
ggcacaagtt tcttactcgc 20
<210> 3154
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3154
tctaatttgt ctaaatttat 20
<210> 3155
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3155
ctctgcactt cagtgtttgt 20
<210> 3156
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3156
atctcagtta tcaatctcag 20
<210> 3157
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3157
ataaccccac acctttactg 20
<210> 3158
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3158
cgaggctcaa ccccattgga 20
<210> 3159
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3159
tatataattg ctaggtagag 20
<210> 3160
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3160
tcattcagct acttttgaaa 20
<210> 3161
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3161
accaacagaa tgaggtgtgc 20
<210> 3162
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3162
attcaaacaa aatgttagta 20
<210> 3163
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3163
actcaatagt caccttcttt 20
<210> 3164
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3164
atgtggaggt atcgaccatt 20
<210> 3165
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3165
cgggaattat ttcacttcat 20
<210> 3166
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3166
ccttgtatct agtctctctc 20
<210> 3167
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3167
ctacaagtca aaaatgtggt 20
<210> 3168
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3168
atcatttcca ttaattattt 20
<210> 3169
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3169
cttagaatga aattgctgat 20
<210> 3170
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3170
tgccaatgtg gagttaattt 20
<210> 3171
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3171
taattattct cagtctttaa 20
<210> 3172
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3172
tcttagcaca ttctctgaac 20
<210> 3173
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3173
gacacatttg aaaagttatt 20
<210> 3174
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3174
tctttagaat attcacacat 20
<210> 3175
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3175
actggcaaat caaacttcat 20
<210> 3176
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3176
aatgtaatct ttatcaggac 20
<210> 3177
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3177
ttggaaaaca gacacaaaag 20
<210> 3178
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3178
ggcctttgct ggtgaagtct 20
<210> 3179
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3179
gaaatcccta ccaattgttc 20
<210> 3180
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3180
caatcaggct ttcttcaagg 20
<210> 3181
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3181
tgatgaagtg acagttaaat 20
<210> 3182
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3182
gtacaactta gagggcctgg 20
<210> 3183
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3183
agttctcaat actctggtat 20
<210> 3184
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3184
atttcacatg atgtcagtag 20
<210> 3185
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3185
agatagaaaa gcaacaaaag 20
<210> 3186
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3186
caacaagtct ttttaaagat 20
<210> 3187
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3187
aacatcagtg attctgatag 20
<210> 3188
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3188
ggatctagta aagcagcatg 20
<210> 3189
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3189
tctctttcat atctctttta 20
<210> 3190
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3190
gaataggaag acagactgtg 20
<210> 3191
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3191
tctttataac agttctatga 20
<210> 3192
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3192
gacaactttt tgctaataat 20
<210> 3193
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3193
ttcaggcctc catacccttg 20
<210> 3194
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3194
agagaatcca tttgactttg 20
<210> 3195
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3195
gaatacagga ataaccactg 20
<210> 3196
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3196
aacagtgcac acagtgtagt 20
<210> 3197
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3197
ctactgtcaa cacagtaatt 20
<210> 3198
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3198
cttctctgcc ccatgatgtc 20
<210> 3199
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3199
tttcttctgt gccaggcacg 20
<210> 3200
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3200
gccactatta agtggtagag 20
<210> 3201
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3201
ccaaggttga ccacacagga 20
<210> 3202
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3202
tcataagatt tgacagcatg 20
<210> 3203
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3203
ttcagaaacc acatttctgc 20
<210> 3204
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3204
caatcagcaa gtattttcag 20
<210> 3205
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3205
gtggtgcttg gactgaaata 20
<210> 3206
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3206
ttgtactata tctaaatttc 20
<210> 3207
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3207
taatctgctt ctcttgtggg 20
<210> 3208
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3208
atattaaact ggcctgaaaa 20
<210> 3209
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3209
agcacatgta aagctttgca 20
<210> 3210
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3210
ctcatgagga cttccacatt 20
<210> 3211
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3211
agattattta gtgcccagca 20
<210> 3212
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3212
cacttcagga gaatgtatat 20
<210> 3213
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3213
tttagcttat gatgaaattc 20
<210> 3214
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3214
cactattcag taagagttcc 20
<210> 3215
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3215
cgctgtaata cggcatctcg 20
<210> 3216
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3216
atgatgtaaa tttattactg 20
<210> 3217
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3217
gatgctgatc tgattatggc 20
<210> 3218
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3218
ggccagtctt tcacatctat 20
<210> 3219
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3219
ttggcacatt tttacgctcc 20
<210> 3220
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3220
aatactgtga catgtagttc 20
<210> 3221
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3221
ccaaaagaat acagcctttt 20
<210> 3222
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3222
gatattggaa tggtgagcct 20
<210> 3223
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3223
tagtaaacca aatgaataaa 20
<210> 3224
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3224
cctttaagct taacagtctt 20
<210> 3225
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3225
ttactggtaa gtatttttac 20
<210> 3226
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3226
ggtaagctat gtaaacaatt 20
<210> 3227
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3227
aactattcat aatcttctca 20
<210> 3228
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3228
ttggctgtgc aaaagaagga 20
<210> 3229
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3229
ctgctacatg ataaggaagc 20
<210> 3230
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3230
cacacccttt atgtactgaa 20
<210> 3231
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3231
tcttagtggc caaagcaact 20
<210> 3232
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3232
tcacaagctc tgtgtcctca 20
<210> 3233
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3233
tcataacccc acacctttac 20
<210> 3234
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3234
ttttttttga tgtggagaaa 20
<210> 3235
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3235
gactcatgta agaagacaag 20
<210> 3236
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3236
tttaatttta actatgaaga 20
<210> 3237
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3237
taacagtttg accaactcta 20
<210> 3238
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3238
aattcaaaca aaatgttagt 20
<210> 3239
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3239
ttactcaata gtcaccttct 20
<210> 3240
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3240
ttccaatact taaaacaagt 20
<210> 3241
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3241
aagatagaat tcatagtaat 20
<210> 3242
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3242
ccatggacct ccaacccaat 20
<210> 3243
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3243
cactacaagt caaaaatgtg 20
<210> 3244
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3244
atttttaagg gagatctctc 20
<210> 3245
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3245
ttcatgtcta ataatcttta 20
<210> 3246
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3246
tctaaagaaa ttcagacaac 20
<210> 3247
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3247
caaagaaaaa agtccaataa 20
<210> 3248
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3248
gcaacctgca ataaaaccca 20
<210> 3249
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3249
agactaagtt gtagagatgc 20
<210> 3250
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3250
taaaataaat aaatgccagc 20
<210> 3251
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3251
actaaaagac tagtgactta 20
<210> 3252
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3252
gaacccattt ctggagggtt 20
<210> 3253
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3253
cactagaaca gctaaaagta 20
<210> 3254
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3254
tcactaacag gataattaaa 20
<210> 3255
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3255
tgaagtgtac tgtaagtata 20
<210> 3256
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3256
cttgaaagtt acaaggataa 20
<210> 3257
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3257
ggtgggtagg ttggctggag 20
<210> 3258
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3258
actgaaatgc cacttttaaa 20
<210> 3259
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3259
atgggtgtta tttaataaaa 20
<210> 3260
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3260
aagtgtaaag accagaaaca 20
<210> 3261
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3261
tagtctccat tctaaaaagc 20
<210> 3262
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3262
gacttattgg taatgatatc 20
<210> 3263
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3263
gcagagacat aaaatcccac 20
<210> 3264
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3264
ttccatgtga aatataagaa 20
<210> 3265
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3265
aaggttaaat tgccatgtaa 20
<210> 3266
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3266
ctaggagagg acttccatga 20
<210> 3267
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3267
attatatggc agacatgttg 20
<210> 3268
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3268
ttggacaact ttttgctaat 20
<210> 3269
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3269
accttcaggc ctccataccc 20
<210> 3270
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3270
cctttatttt tataaattga 20
<210> 3271
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3271
tacagttgag ttctggtata 20
<210> 3272
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3272
gaaacagtgc acacagtgta 20
<210> 3273
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3273
aaaaactaga acctagagtt 20
<210> 3274
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3274
agatgtctat aaaattctga 20
<210> 3275
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3275
aaccaggcat tggaatctgg 20
<210> 3276
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3276
aatttcttga tgaacatcat 20
<210> 3277
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3277
ctaaaccagg ctgtgttatt 20
<210> 3278
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3278
ttttcataag atttgacagc 20
<210> 3279
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3279
tttaacctca gaactaatgt 20
<210> 3280
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3280
atcagatgtc atttatcatt 20
<210> 3281
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3281
agcacaaagt cacctaacct 20
<210> 3282
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3282
tctatgtggc tctttgtaga 20
<210> 3283
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3283
agctgcagta atctgcttct 20
<210> 3284
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3284
atatattaaa ctggcctgaa 20
<210> 3285
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3285
caaacagcac atgtaaagct 20
<210> 3286
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3286
actcatgagg acttccacat 20
<210> 3287
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3287
gagattattt agtgcccagc 20
<210> 3288
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3288
ccacttcagg agaatgtata 20
<210> 3289
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3289
tatttagctt atgatgaaat 20
<210> 3290
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3290
agatccacta ttcagtaaga 20
<210> 3291
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3291
acgctgtaat acggcatctc 20
<210> 3292
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3292
gattagcaat acaactcatt 20
<210> 3293
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3293
agatgctgat ctgattatgg 20
<210> 3294
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3294
ggataggcca gtctttcaca 20
<210> 3295
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3295
aattggcaca tttttacgct 20
<210> 3296
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3296
aaaatactgt gacatgtagt 20
<210> 3297
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3297
acaacttggc ccaaaagaat 20
<210> 3298
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3298
tcagccaaaa tcaagtcagg 20
<210> 3299
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3299
tagagtagta aaccaaatga 20
<210> 3300
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3300
cagctccttt aagcttaaca 20
<210> 3301
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3301
cacatttact ggtaagtatt 20
<210> 3302
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3302
aattattaca taggtatttg 20
<210> 3303
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3303
ggtatactac aactaaaggc 20
<210> 3304
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3304
caaatattgg ctgtgcaaaa 20
<210> 3305
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3305
taagccagat tgtataagaa 20
<210> 3306
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3306
acacaccctt tatgtactga 20
<210> 3307
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3307
ctacctctta gtggccaaag 20
<210> 3308
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3308
taattgaact gtactgtcac 20
<210> 3309
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3309
cactcataac cccacacctt 20
<210> 3310
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3310
tgttatattg cttacctttt 20
<210> 3311
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3311
tcaatggctc tatttaacac 20
<210> 3312
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3312
gttttaattt taactatgaa 20
<210> 3313
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3313
cattatatat attatctact 20
<210> 3314
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3314
aaattcaaac aaaatgttag 20
<210> 3315
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3315
cttactcaat agtcaccttc 20
<210> 3316
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3316
acacatgtca tttccaattt 20
<210> 3317
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3317
taattgtcta aactttgaac 20
<210> 3318
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3318
tcacatcaaa cagatctccc 20
<210> 3319
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3319
tgtagctgaa ctatgctaaa 20
<210> 3320
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3320
tgtattaaag tttgagtata 20
<210> 3321
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3321
ccacagtgaa cattcatgtc 20
<210> 3322
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3322
gtccaaatat aaaggcaaaa 20
<210> 3323
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3323
agaagtggta agttaaaaag 20
<210> 3324
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3324
ccagtatctt gaattcctta 20
<210> 3325
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3325
tatcaaaaca ttagaactat 20
<210> 3326
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3326
gagaaagtga atctgataaa 20
<210> 3327
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3327
atctttggct taaggtccct 20
<210> 3328
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3328
tgaagattaa agtaagcagg 20
<210> 3329
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3329
aataagaatg gccaataaga 20
<210> 3330
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3330
caggataatt aaatcactaa 20
<210> 3331
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3331
tcttgaagtg tactgtaagt 20
<210> 3332
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3332
aaatgtcttg aaagttacaa 20
<210> 3333
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3333
accgaatgag aattaggtgg 20
<210> 3334
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3334
ataattttgt ctcttccaga 20
<210> 3335
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3335
tatggtacta gctcataaag 20
<210> 3336
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3336
tatgagaaag taataagacc 20
<210> 3337
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3337
gtttagtctc cattctaaaa 20
<210> 3338
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3338
aggtgattta taagtgccaa 20
<210> 3339
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3339
ggttatttgt aaaatgttat 20
<210> 3340
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3340
cattttccat gtgaaatata 20
<210> 3341
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3341
aaattccttt gtatttctcc 20
<210> 3342
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3342
gtctcatcaa taatatattc 20
<210> 3343
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3343
tgttattata tggcagacat 20
<210> 3344
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3344
ctcaaatttt ggacaacttt 20
<210> 3345
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3345
atgctttgta ccttcaggcc 20
<210> 3346
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3346
ttagaaacac ttgaagtcat 20
<210> 3347
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3347
aattaaaatg cccccaggat 20
<210> 3348
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3348
ctctgttttt atcagacatt 20
<210> 3349
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3349
gttatttaaa gtaaggtttc 20
<210> 3350
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3350
ttcatctcaa ccaggtctta 20
<210> 3351
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3351
agttgcatat ggtttaggag 20
<210> 3352
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3352
aatatttact tcaatatgga 20
<210> 3353
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3353
catccaagga ggcatacact 20
<210> 3354
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3354
ttaaaggaaa agttaaccag 20
<210> 3355
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3355
gattgttcct ctccctctcc 20
<210> 3356
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3356
taatgactaa ataggaatct 20
<210> 3357
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3357
gtagatttag tggtattgag 20
<210> 3358
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3358
actttatatt aatttcttgt 20
<210> 3359
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3359
taccatgtat ttcccatttt 20
<210> 3360
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3360
ttctgttaaa actatatatt 20
<210> 3361
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3361
acttaacaat atcatataat 20
<210> 3362
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3362
attgccactc atgaggactt 20
<210> 3363
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3363
cataaggaga ttatttagtg 20
<210> 3364
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3364
ttcagccact tcaggagaat 20
<210> 3365
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3365
aaccatattt agcttatgat 20
<210> 3366
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3366
tgtcaccttt cccaatgctt 20
<210> 3367
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3367
gtgaatcatc tgaagataat 20
<210> 3368
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3368
tctaccacat cagtgaggtt 20
<210> 3369
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3369
gtttctctac tctagaccat 20
<210> 3370
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3370
gtactataga attcctcacg 20
<210> 3371
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3371
aattcaattg gcacattttt 20
<210> 3372
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3372
gaatttttct aggagcttaa 20
<210> 3373
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3373
tggtccacaa cttggcccaa 20
<210> 3374
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3374
tatttctagg caggtcagcc 20
<210> 3375
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3375
aggcctttct tgaggatttt 20
<210> 3376
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3376
gagaaaatct ttgtgccaca 20
<210> 3377
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3377
acagaattta aaataaagtt 20
<210> 3378
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3378
tatcacaggg aattatctga 20
<210> 3379
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3379
atcaccttgg cctataattt 20
<210> 3380
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3380
ttgcttttta ctagcttgca 20
<210> 3381
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3381
ggctctttca catttcgaaa 20
<210> 3382
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3382
tttcctacat aaacttttat 20
<210> 3383
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3383
gttgagtacc ttcttgtttt 20
<210> 3384
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3384
tcttgtgtat tataattatc 20
<210> 3385
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3385
agcaatcatt ggtagcatac 20
<210> 3386
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3386
gtactgaaaa tgaaagtctg 20
<210> 3387
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3387
aaggtaaggt ctcaaccaga 20
<210> 3388
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3388
tcattggcat gtttaccatt 20
<210> 3389
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3389
ctaacaataa aagttacggt 20
<210> 3390
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3390
aatttggtta taaaagagta 20
<210> 3391
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3391
caggtcttac tcaatagtca 20
<210> 3392
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3392
agcatcaggt tcaaaagcaa 20
<210> 3393
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3393
cattgtagtt actttgtata 20
<210> 3394
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3394
aaactatgaa taggacacca 20
<210> 3395
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3395
ctggaagatt tttatgcaac 20
<210> 3396
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3396
ctctcacaat gagacaggat 20
<210> 3397
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3397
ggtggagaaa taaaaatatc 20
<210> 3398
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3398
gatgtccctt gtctatgagt 20
<210> 3399
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3399
gtctttgacc aaaatcttct 20
<210> 3400
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3400
ctatcttggt ttaatcagcc 20
<210> 3401
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3401
atatattttc atagactgac 20
<210> 3402
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3402
catcttgaaa caggaaaccc 20
<210> 3403
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3403
gcttgaaagt ataaagaaaa 20
<210> 3404
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3404
gctaaataaa ggatcttgtt 20
<210> 3405
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3405
tcttaagtgg gatacaaaaa 20
<210> 3406
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3406
aattacaact tcaatatttc 20
<210> 3407
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3407
caaagtgaac ctgagaataa 20
<210> 3408
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3408
tctgtttcca ttgcctgccc 20
<210> 3409
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3409
attattttgc ttgctcattt 20
<210> 3410
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3410
tatctcagta tcaggatgcc 20
<210> 3411
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3411
tacataaact tgcctaatct 20
<210> 3412
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3412
atggaaatct ggatttatag 20
<210> 3413
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3413
tcagaaaaca aaatccttcc 20
<210> 3414
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3414
cattaaaaaa tacccaaatt 20
<210> 3415
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3415
tcaaaccatt atgccagaat 20
<210> 3416
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3416
aatgtgaaac agacacgcta 20
<210> 3417
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3417
aatgtttcaa tatgctcttg 20
<210> 3418
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3418
attttaagcc tccaagtttc 20
<210> 3419
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3419
caaaataaat gatacatgtc 20
<210> 3420
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3420
catcctaatt tttattctca 20
<210> 3421
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3421
agccaaaatg gcaacagctc 20
<210> 3422
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3422
tcattccact ttgattgtgt 20
<210> 3423
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3423
ggaattttct tcaaattttg 20
<210> 3424
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3424
tcataggcac agacagaggt 20
<210> 3425
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3425
actacagttg acctatggac 20
<210> 3426
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3426
attgcaagca taaacagatt 20
<210> 3427
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3427
atgaatattt taactatttc 20
<210> 3428
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3428
gctattcatg gctctgttgt 20
<210> 3429
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3429
gttagaattt ggaatcacag 20
<210> 3430
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3430
caaatgtgga gttctaacag 20
<210> 3431
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3431
tggacaaggt tacttgggca 20
<210> 3432
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3432
tttataaatg tctcagctag 20
<210> 3433
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3433
attgctatag ccactacgga 20
<210> 3434
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3434
ctagaactcc aaaagtccta 20
<210> 3435
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3435
acaagctaga ctattgcaat 20
<210> 3436
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3436
gaatatattt tcttcaccat 20
<210> 3437
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3437
aaactaccaa ttaaaattcc 20
<210> 3438
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3438
cacttaacaa tatcatataa 20
<210> 3439
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3439
cattgccact catgaggact 20
<210> 3440
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3440
tgttttggta cataaggaga 20
<210> 3441
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3441
tttcagccac ttcaggagaa 20
<210> 3442
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3442
taaccatatt tagcttatga 20
<210> 3443
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3443
ctgtcacctt tcccaatgct 20
<210> 3444
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3444
ctagtgatgt aatatattct 20
<210> 3445
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3445
gtttctctac cacatcagtg 20
<210> 3446
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3446
cagtttctct actctagacc 20
<210> 3447
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3447
gagtactata gaattcctca 20
<210> 3448
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3448
cgggaaattc aattggcaca 20
<210> 3449
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3449
ggaatttttc taggagctta 20
<210> 3450
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3450
ttcagctgaa ttcaaaatgt 20
<210> 3451
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3451
ccactgttat gatgttggaa 20
<210> 3452
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3452
atttctagaa aaatcgacaa 20
<210> 3453
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3453
tgtcctatca cagggaatta 20
<210> 3454
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3454
gtctgtcaag cctctcaacc 20
<210> 3455
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3455
tatcaaacca ttttgctttt 20
<210> 3456
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3456
cagatttctc tagaatgaat 20
<210> 3457
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3457
tgtgtctatc ttcttcacaa 20
<210> 3458
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3458
agactcttag tgcatgccat 20
<210> 3459
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3459
ccttagaaac acagtaaact 20
<210> 3460
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3460
aaaacagaat atgaaccatt 20
<210> 3461
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3461
ggaaaagtac tgaaaatgaa 20
<210> 3462
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3462
cagactctct gcaaggtaag 20
<210> 3463
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3463
cttaaaggaa tagtgcttag 20
<210> 3464
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3464
aattaccaaa tgacccttga 20
<210> 3465
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3465
tggtgtttac tatgggttcc 20
<210> 3466
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3466
tgcaggtctt actcaatagt 20
<210> 3467
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3467
cacacaataa ttagaaaaac 20
<210> 3468
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3468
tcatggcaac aaaaatagaa 20
<210> 3469
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3469
tgtcaacttt aaggataatc 20
<210> 3470
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3470
taaatataat gtgtaagaat 20
<210> 3471
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3471
caccaacact caccatgaat 20
<210> 3472
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3472
ccctcaggga cctctactga 20
<210> 3473
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3473
atttatcagt gtctacttag 20
<210> 3474
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3474
ttcatttaga tgatgttttg 20
<210> 3475
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3475
actctactat agagattcta 20
<210> 3476
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3476
atttaataat gtgtattaaa 20
<210> 3477
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3477
tacaaaccat cttgaaacag 20
<210> 3478
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3478
atgagcttga aagtataaag 20
<210> 3479
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3479
gtatcagtgt cctcacctgg 20
<210> 3480
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3480
ttcttaagtg ggatacaaaa 20
<210> 3481
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3481
atagtcctta atgtttgcac 20
<210> 3482
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3482
tttcaaagtg aacctgagaa 20
<210> 3483
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3483
atctgtttcc attgcctgcc 20
<210> 3484
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3484
ccttgtcaca gtctcttcca 20
<210> 3485
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3485
aaaaccatta aatgattaat 20
<210> 3486
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3486
aacacactca agatccaatt 20
<210> 3487
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3487
atcacacata atttgaaatg 20
<210> 3488
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3488
agtataatac actgaaagct 20
<210> 3489
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3489
agctgtaaaa aagttaataa 20
<210> 3490
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3490
ttttcaaacc attatgccag 20
<210> 3491
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3491
aaacttaatg tgaaacagac 20
<210> 3492
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3492
gcaatgtttc aatatgctct 20
<210> 3493
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3493
gaatgaagcc aagtgaataa 20
<210> 3494
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3494
agtgtcagat gcaatgtttt 20
<210> 3495
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3495
aggagaaaat tacatcctaa 20
<210> 3496
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3496
aagaggaaat gtaccctgtg 20
<210> 3497
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3497
ctctctctct tgcaaaatta 20
<210> 3498
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3498
aattcaaaag gtcaaatttt 20
<210> 3499
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3499
ttgttttcat aggcacagac 20
<210> 3500
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3500
ttcagtaata aaaagctggt 20
<210> 3501
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3501
caaggaattg caagcataaa 20
<210> 3502
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3502
gtctaatatt acacagcaaa 20
<210> 3503
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3503
atatttgcta ttcatggctc 20
<210> 3504
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3504
agcatatttt ttcttgataa 20
<210> 3505
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3505
taaaaatcac caaatgtgga 20
<210> 3506
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3506
gataatatgg tggacaaggt 20
<210> 3507
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3507
gattcattga tctgaggaga 20
<210> 3508
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3508
taaattgcta tagccactac 20
<210> 3509
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3509
ttgccgacct aggactaaaa 20
<210> 3510
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3510
aaaaaataga aagtcatcac 20
<210> 3511
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3511
ttcctctttc acatatactt 20
<210> 3512
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3512
taaactacca attaaaattc 20
<210> 3513
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3513
gcacttaaca atatcatata 20
<210> 3514
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3514
cctgacattg ccactcatga 20
<210> 3515
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3515
agctgggaaa tggccatctt 20
<210> 3516
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3516
ctttcagcca cttcaggaga 20
<210> 3517
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3517
tttaaccata tttagcttat 20
<210> 3518
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3518
gctgtcacct ttcccaatgc 20
<210> 3519
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3519
aaggtctagt gatgtaatat 20
<210> 3520
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3520
ttttatttcc ttctaaaatg 20
<210> 3521
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3521
gcagtttctc tactctagac 20
<210> 3522
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3522
tgagtactat agaattcctc 20
<210> 3523
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3523
cggtcaatta cgggaaattc 20
<210> 3524
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3524
ctggaatttt tctaggagct 20
<210> 3525
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3525
tgtggtccac aacttggccc 20
<210> 3526
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3526
tcggtaaact gatccaaaac 20
<210> 3527
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3527
actaattcag ctgaattcaa 20
<210> 3528
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3528
taccaccact gttatgatgt 20
<210> 3529
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3529
tgcagatttc tagaaaaatc 20
<210> 3530
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3530
tataaataaa tttaaagttt 20
<210> 3531
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3531
aaagattgag atgcctcatg 20
<210> 3532
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3532
gtaggagacc cctttctaca 20
<210> 3533
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3533
aatgaagcta gaataataga 20
<210> 3534
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3534
gagtgatcta atacactcca 20
<210> 3535
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3535
ccgtcaaaaa aaaaatacct 20
<210> 3536
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3536
ctcgctgcaa tacactttgt 20
<210> 3537
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3537
caaaacagaa tatgaaccat 20
<210> 3538
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3538
tattgcctga atttaaagag 20
<210> 3539
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3539
acttttaaat gcattgttgt 20
<210> 3540
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3540
tttaaagttg aaactcttaa 20
<210> 3541
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3541
tgaattaata tggcatttta 20
<210> 3542
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3542
aaacagagga ggaaagtgat 20
<210> 3543
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3543
tcagaggcaa aaaacaatat 20
<210> 3544
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3544
cgttgtgaaa gagcaaaatt 20
<210> 3545
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3545
gtacaattca aacaagagaa 20
<210> 3546
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3546
gaaatactgt attcaaaact 20
<210> 3547
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3547
gactgttact ttctagaaat 20
<210> 3548
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3548
ggctaactgg aaccagttat 20
<210> 3549
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3549
gactctgctt gttgtagtcc 20
<210> 3550
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3550
taatgtattg cattggtgct 20
<210> 3551
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3551
taaaaattat agtgccatcc 20
<210> 3552
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3552
aatgctacag cagagcaggc 20
<210> 3553
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3553
aactattggc aaacatagta 20
<210> 3554
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3554
catacagacc tacaaaccat 20
<210> 3555
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3555
cataatatgt acaaaataca 20
<210> 3556
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3556
agtgatcctg aataattaac 20
<210> 3557
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3557
tttcttaagt gggatacaaa 20
<210> 3558
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3558
aattcttcca gaggaagaaa 20
<210> 3559
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3559
attggagaat aggttagaac 20
<210> 3560
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3560
gatctgtttc cattgcctgc 20
<210> 3561
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3561
tgtccagtca ttgaatgccg 20
<210> 3562
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3562
cttttaataa aagtgatgat 20
<210> 3563
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3563
acaacacact caagatccaa 20
<210> 3564
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3564
aacagttaag aataatttga 20
<210> 3565
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3565
cactatttga aaaaatgtct 20
<210> 3566
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3566
gactgccact gtactatttg 20
<210> 3567
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3567
gcaatcaaat gagttttcaa 20
<210> 3568
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3568
atcagtggcc tattaaagaa 20
<210> 3569
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3569
tgcaatgttt caatatgctc 20
<210> 3570
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3570
caatactcca aaaacatgca 20
<210> 3571
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3571
ttagttatgc atagacaaat 20
<210> 3572
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3572
atataattat gaaatctatt 20
<210> 3573
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3573
gagtatggat tgtcatgtct 20
<210> 3574
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3574
acaaaaagtc tttttgaggc 20
<210> 3575
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3575
ttactactat atatatatca 20
<210> 3576
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3576
catgtcagtt ggttagaact 20
<210> 3577
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3577
tattactact tgctatgagg 20
<210> 3578
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3578
atgagctctc taggcagaca 20
<210> 3579
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3579
agtctaatat tacacagcaa 20
<210> 3580
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3580
tttttccagg tggaaatata 20
<210> 3581
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3581
attcaaaaac tatttaaatg 20
<210> 3582
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3582
taatgagtac acagtaattc 20
<210> 3583
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3583
tcagataata tggtggacaa 20
<210> 3584
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3584
agaggcccta caaagattca 20
<210> 3585
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3585
tcaacaatat agagaggatc 20
<210> 3586
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3586
tgtatttaat agaaaatagt 20
<210> 3587
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3587
tgaagtgcaa agataattct 20
<210> 3588
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3588
ctgagacaac ctattgagag 20
<210> 3589
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3589
catatcactt gtaattttga 20
<210> 3590
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3590
acgcacttaa caatatcata 20
<210> 3591
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3591
ttccaccaca atattataac 20
<210> 3592
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3592
ctatgagctg ggaaatggcc 20
<210> 3593
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3593
actttcagcc acttcaggag 20
<210> 3594
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3594
cattcttgaa acactgtttt 20
<210> 3595
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3595
tggctgtcac ctttcccaat 20
<210> 3596
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3596
ctccagcttt tcaagatgct 20
<210> 3597
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3597
atgaaatgtg gttcttacta 20
<210> 3598
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3598
tgcagtttct ctactctaga 20
<210> 3599
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3599
atgagtacta tagaattcct 20
<210> 3600
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3600
tccggtcaat tacgggaaat 20
<210> 3601
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3601
aatgtggtcc acaacttggc 20
<210> 3602
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3602
gctgctcggt aaactgatcc 20
<210> 3603
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3603
tgcttgcatt cctgctgttg 20
<210> 3604
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3604
aacagggcta ttttgcttag 20
<210> 3605
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3605
tacattacat gggaaactgt 20
<210> 3606
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3606
aatacagaaa atctttcatc 20
<210> 3607
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3607
atcaggcact tctgaacacc 20
<210> 3608
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3608
agtgagtatt aaaatgtcag 20
<210> 3609
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3609
tgctccccaa gtaatgaagc 20
<210> 3610
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3610
gattttaatc cctatgttat 20
<210> 3611
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3611
acttcaatat attccagtgt 20
<210> 3612
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3612
tgctattctg acttttgaca 20
<210> 3613
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3613
gttaatggtc acttacaaaa 20
<210> 3614
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3614
gacactcctt ttaaaagtcc 20
<210> 3615
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3615
ttcagcaacc actctcactt 20
<210> 3616
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3616
ttcattgtgt aaaataactt 20
<210> 3617
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3617
atcacagatg gctctgcaat 20
<210> 3618
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3618
ataatagaca attttaccag 20
<210> 3619
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3619
agaacatttt acacactatc 20
<210> 3620
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3620
ctatataatc ttagcatctc 20
<210> 3621
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3621
cattgaggta aatgagtaca 20
<210> 3622
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3622
ttgataccta gaatgatacg 20
<210> 3623
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3623
atagtataaa tacagaaaac 20
<210> 3624
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3624
ttggctaact ggaaccagtt 20
<210> 3625
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3625
ggaaggaaaa aacgaatacc 20
<210> 3626
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3626
atcttgaaat agtaatgtat 20
<210> 3627
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3627
tgggacttga atataaatgt 20
<210> 3628
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3628
ttgataagca aagtagcctt 20
<210> 3629
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3629
taaactattg gcaaacatag 20
<210> 3630
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3630
aggtgattta tgttttactc 20
<210> 3631
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3631
tcagaagatg gtaacttacc 20
<210> 3632
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3632
taagagatac accagcaact 20
<210> 3633
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3633
ggtttcttaa gtgggataca 20
<210> 3634
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3634
tacataagaa gaaatttaaa 20
<210> 3635
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3635
attaacacaa aacaaccctc 20
<210> 3636
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3636
cagatctgtt tccattgcct 20
<210> 3637
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3637
agcaaacccc tacttacaca 20
<210> 3638
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3638
tctacaactt ttaataaaag 20
<210> 3639
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3639
aaagataaat ttacacatat 20
<210> 3640
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3640
agaattttta tccttatact 20
<210> 3641
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3641
ccactatttg aaaaaatgtc 20
<210> 3642
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3642
attcactcct aaataaaata 20
<210> 3643
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3643
atgatctcta atagattaaa 20
<210> 3644
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3644
acatgatttg tcatgaacac 20
<210> 3645
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3645
taagtgctct gggtcacact 20
<210> 3646
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3646
agcaccaata ctccaaaaac 20
<210> 3647
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3647
attagttatg catagacaaa 20
<210> 3648
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3648
aatctatgac aatataatta 20
<210> 3649
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3649
atatggagta tggattgtca 20
<210> 3650
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3650
actagttttt attctacctt 20
<210> 3651
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3651
ctaacatata ctcttggagc 20
<210> 3652
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3652
aatctttttt ttaatgccca 20
<210> 3653
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3653
tgatgggttc tagagcagaa 20
<210> 3654
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3654
gctaacactt catgacacac 20
<210> 3655
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3655
agcatcaaaa attctgtgct 20
<210> 3656
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3656
gtggtccagt ccaccttcat 20
<210> 3657
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3657
ttatgcttcc cttcttagaa 20
<210> 3658
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3658
aaaacattcc aggataatga 20
<210> 3659
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3659
taaaacatga caagagttct 20
<210> 3660
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3660
tcttaatttg gtagttagat 20
<210> 3661
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3661
gatgaaagta ggccccactc 20
<210> 3662
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3662
tgtcagagag ccactacgct 20
<210> 3663
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3663
ttctctattc agaggcagaa 20
<210> 3664
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3664
ttcaactaga gaatgcaaca 20
<210> 3665
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3665
aaagatccat cataaaacat 20
<210> 3666
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3666
ttaacaatat catataatct 20
<210> 3667
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3667
tgccactcat gaggacttcc 20
<210> 3668
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3668
taaggagatt atttagtgcc 20
<210> 3669
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3669
tcagccactt caggagaatg 20
<210> 3670
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3670
accatattta gcttatgatg 20
<210> 3671
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3671
tcacctttcc caatgcttat 20
<210> 3672
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3672
aaatcttcat gatcaaaaat 20
<210> 3673
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3673
gtaggatcta aaaccactga 20
<210> 3674
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3674
tctagaccat aaatatgctt 20
<210> 3675
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3675
tactatagaa ttcctcacga 20
<210> 3676
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3676
attcaattgg cacattttta 20
<210> 3677
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3677
aatttttcta ggagcttaaa 20
<210> 3678
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3678
gtccacaact tggcccaaaa 20
<210> 3679
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3679
caggtcagcc aaaatcaagt 20
<210> 3680
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3680
tttcttgagg attttctttc 20
<210> 3681
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3681
attacatttc tttccgttga 20
<210> 3682
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3682
aaattatcgg ccttataaat 20
<210> 3683
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3683
ggccaaagaa tttaccgaaa 20
<210> 3684
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3684
tttttaaggc cccctttaaa 20
<210> 3685
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3685
ttaggtctgt cacaagctct 20
<210> 3686
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3686
cagtctgttt acaagatgcc 20
<210> 3687
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3687
tgaacagttg gtttgtacag 20
<210> 3688
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3688
ggactgatga ggacaattca 20
<210> 3689
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3689
aggtgatcta tcccattctg 20
<210> 3690
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3690
gtggctaaat ttcaaagcct 20
<210> 3691
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3691
tggaaatgta atgtattggt 20
<210> 3692
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3692
gcagttggtt tagactcccc 20
<210> 3693
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3693
aggaaaaact ttacctgata 20
<210> 3694
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3694
attttctatc atataaaatc 20
<210> 3695
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3695
taaaattttg tatatgtcat 20
<210> 3696
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3696
aggtcttact caatagtcac 20
<210> 3697
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3697
ctgaaattaa ctgagatttt 20
<210> 3698
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3698
tataaaaatt aatctaagtg 20
<210> 3699
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3699
ctgattgaat agccaccaga 20
<210> 3700
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3700
aagctcagag ttacttggac 20
<210> 3701
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3701
gacgcggcaa ctgtggcaat 20
<210> 3702
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3702
atgaatgatt accatgtaag 20
<210> 3703
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3703
tccaacatca tatgactgat 20
<210> 3704
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3704
cagtttctca ccctgtgtcc 20
<210> 3705
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3705
agttacaaaa aatatttcct 20
<210> 3706
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3706
gaattatatt ttgaagggag 20
<210> 3707
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3707
ccattttata ttctctatta 20
<210> 3708
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3708
tacatgtaag catataaaaa 20
<210> 3709
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3709
cctgatggaa tttcaaagtt 20
<210> 3710
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3710
ttaagtggga tacaaaaagc 20
<210> 3711
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3711
atatttctct atcaaataca 20
<210> 3712
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3712
ggctcccaat ttcctcaact 20
<210> 3713
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3713
tgtttccatt gcctgccctc 20
<210> 3714
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3714
aattgaagga ttaccaagtt 20
<210> 3715
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3715
tgcatgttta gtttaagact 20
<210> 3716
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3716
gtttttacac aatgatccac 20
<210> 3717
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3717
tcatgaaatt ggtatttaga 20
<210> 3718
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3718
agagatttta ggcagaagag 20
<210> 3719
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3719
tgtatgcagc caattacatg 20
<210> 3720
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3720
aaaccattat gccagaatgc 20
<210> 3721
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3721
cttttggata ttattatatt 20
<210> 3722
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3722
aataatttta ggaactcggg 20
<210> 3723
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3723
acattatctt gactttatca 20
<210> 3724
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3724
tagactacag ttagtttgac 20
<210> 3725
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3725
attacctagg agaaactctg 20
<210> 3726
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3726
ttctgtaaat gaacatggga 20
<210> 3727
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3727
ctctcctgtt cagaaacaaa 20
<210> 3728
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3728
gagggcgagg aaactaactc 20
<210> 3729
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3729
caccattccc ttagtttgcc 20
<210> 3730
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3730
aagtgcatga gtccacatat 20
<210> 3731
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3731
tagagtcaag gacctggtgg 20
<210> 3732
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3732
cttctgtttg agtatataat 20
<210> 3733
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3733
ttagagttgc atatggttta 20
<210> 3734
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3734
atttggaatc acaggctctt 20
<210> 3735
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3735
ttatgcacta aacaaaaaaa 20
<210> 3736
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3736
tgggacccca aaggactgca 20
<210> 3737
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3737
tttatttaat tttcagcaat 20
<210> 3738
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3738
atatcaaagg gattcctata 20
<210> 3739
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3739
cctctcagtc ggtgtgtact 20
<210> 3740
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3740
tagactattg caattatttc 20
<210> 3741
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3741
tattttcttc accatgttca 20
<210> 3742
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3742
taccatatgt aatattttct 20
<210> 3743
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3743
cctgctgcac actcgcgact 20
<210> 3744
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3744
cttccacatt attgcaagga 20
<210> 3745
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3745
gctgcattct ctgggtactg 20
<210> 3746
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3746
aatgtatatg cttctgcatt 20
<210> 3747
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3747
tttacagcca ctttcagcca 20
<210> 3748
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3748
atcctttagt ctgtatttca 20
<210> 3749
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3749
gacagcacat cttcagaaaa 20
<210> 3750
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3750
aaatgtgtca aactcttcag 20
<210> 3751
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3751
tgcgggacct ggtaggtact 20
<210> 3752
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3752
cccatttcat tgggaaagga 20
<210> 3753
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3753
agttccttgg tgattttact 20
<210> 3754
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3754
attttacaaa gccacttggg 20
<210> 3755
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3755
ggcatttcat atagtcggat 20
<210> 3756
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3756
gccttggttg atctggattt 20
<210> 3757
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3757
gtgcaatcct gtgctgtagg 20
<210> 3758
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3758
tactatcagc aacttcctca 20
<210> 3759
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3759
cgtataagtc gacgagttga 20
<210> 3760
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3760
tcagggtatc cacattcaaa 20
<210> 3761
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3761
ttacctgctg cacactcgcg 20
<210> 3762
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3762
tccttatttt ccagcatact 20
<210> 3763
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3763
tctctctaag agagaaggtt 20
<210> 3764
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3764
cttcatggtt tgaattcaaa 20
<210> 3765
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3765
aaatcatcaa ttgtatacct 20
<210> 3766
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3766
ctcaatcagt acttctagcc 20
<210> 3767
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3767
agtttatcta gcttgagaat 20
<210> 3768
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3768
aaaccatggc ctttctctat 20
<210> 3769
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3769
ccaaaacatt attatccaga 20
<210> 3770
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3770
agaaatttgg gttctcagcc 20
<210> 3771
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3771
aaatgcctct gtaagaatcc 20
<210> 3772
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3772
aagtgaggag aagagaatgg 20
<210> 3773
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3773
tctaaaggtg ccccaacaga 20
<210> 3774
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3774
atcacataca cattctaaaa 20
<210> 3775
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3775
atagattagt tagactgatg 20
<210> 3776
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3776
ttctgcttga aatgtcttcc 20
<210> 3777
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3777
tctttgttct atcacttgag 20
<210> 3778
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3778
ccttcttctc tttttcatac 20
<210> 3779
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3779
taaaaattta gtccttcatc 20
<210> 3780
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3780
agggtgcata gtctgtaggt 20
<210> 3781
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3781
ctgtttggca ggcaaggcca 20
<210> 3782
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3782
attctaaatc ctgaattcaa 20
<210> 3783
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3783
aggatgttca tttaactata 20
<210> 3784
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3784
gaatatggaa agaggaataa 20
<210> 3785
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3785
tccatcagtt actgtgctaa 20
<210> 3786
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3786
gaagagagaa tttagagcta 20
<210> 3787
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3787
aaagcccctc actccatttt 20
<210> 3788
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3788
aagttagttg attaaaaatt 20
<210> 3789
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3789
ataaatttgg ctggcaataa 20
<210> 3790
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3790
gttaatggta tttataatta 20
<210> 3791
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3791
attttcagag agctatccta 20
<210> 3792
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3792
ctttcttacc cttctaaaat 20
<210> 3793
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3793
ctgagatgac acactgacca 20
<210> 3794
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3794
ctcttcaaga cattgaaagt 20
<210> 3795
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3795
gaaatgaagg gctttggaat 20
<210> 3796
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3796
ataagaagtt gaatcagaaa 20
<210> 3797
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3797
ctcttaaccc agagaattag 20
<210> 3798
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3798
acagagcata tttcacacat 20
<210> 3799
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3799
ccacagaatc ttcaggaatt 20
<210> 3800
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3800
ttggataaat tattcaacct 20
<210> 3801
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3801
tgatcatgct aaacgcaaaa 20
<210> 3802
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3802
gaatattgaa acatggttac 20
<210> 3803
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3803
tcttggtatt ctctcattct 20
<210> 3804
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3804
ttacaacaca ctatgtatca 20
<210> 3805
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3805
attaaaccaa tataccaagg 20
<210> 3806
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3806
gcaattcaaa aaaagtccga 20
<210> 3807
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3807
tgagagaaat tgttagaagc 20
<210> 3808
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3808
tttatagaac acagactctt 20
<210> 3809
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3809
agggaggtaa gattccacag 20
<210> 3810
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3810
catatgtcag agggtcctaa 20
<210> 3811
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3811
tttgctaaaa ttatctgtgc 20
<210> 3812
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3812
gatggtgaaa attataggag 20
<210> 3813
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3813
aaaaaccctt gggccaacaa 20
<210> 3814
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3814
ccctgctgtg ataggcttga 20
<210> 3815
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3815
ttgaaagagg tttatattaa 20
<210> 3816
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3816
ggtgtcactg tcatattata 20
<210> 3817
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3817
atagtctaat tcatgacaaa 20
<210> 3818
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3818
ctatgtaggc cctaggctag 20
<210> 3819
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3819
ccctttccat gtgaaca 17
<210> 3820
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3820
catatctaaa gaccgcaagc 20
<210> 3821
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3821
gttccttcag tctcaagggg 20
<210> 3822
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3822
ttccttcagt ctcaaggggg 20
<210> 3823
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3823
tccttcagtc tcaaggggga 20
<210> 3824
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3824
tcataagttt cattcggtta 20
<210> 3825
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3825
ctttctcaca tacctattaa 20
<210> 3826
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3826
tctttctcac atacctatta 20
<210> 3827
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3827
ctctttctca catacctatt 20
<210> 3828
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3828
tctctttctc acatacctat 20
<210> 3829
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3829
taacaatatc atataat 17
<210> 3830
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3830
ttaacaatat catataa 17
<210> 3831
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3831
cttaacaata tcatata 17
<210> 3832
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3832
acttaacaat atcatat 17
<210> 3833
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3833
cacttaacaa tatcata 17
<210> 3834
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3834
agcactgaat ccatagc 17
<210> 3835
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3835
acatttctga atcccag 17
<210> 3836
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3836
ccttcagtct caagggg 17
<210> 3837
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3837
atatctaaag accgcaa 17
<210> 3838
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3838
aaactcatgg acttcgt 17
<210> 3839
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3839
cattcggtta taaggca 17
<210> 3840
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3840
accctttcca tgtgaac 17
<210> 3841
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3841
tttcatagct tccacca 17
<210> 3842
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3842
catgaggact tccacat 17
<210> 3843
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3843
catggcatca aaaatta 17
<210> 3844
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3844
cacaaactca tggactt 17
<210> 3845
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3845
agttccttca gtctcaa 17
<210> 3846
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3846
ttcggttata aggcaca 17
<210> 3847
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3847
atttagctta tgatgaa 17
<210> 3848
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Oligonucleotide
<400> 3848
cctataggac tatccaggaa 20
Claims (74)
12 내지 50개의 연결된 뉴클레오사이드로 이루어지는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물이며, 상기 변형된 올리고뉴클레오타이드의 핵염기 서열이 LRRK2 핵산의 동일 길이 부분에 적어도 90% 상보성이고, 상기 변형된 올리고뉴클레오타이드가 변형된 당 및 변형된 인터뉴클레오사이드 연결기로부터 선택된 적어도 하나의 변형을 포함하는, 올리고머성 화합물.
12 내지 50개의 연결된 뉴클레오사이드로 이루어지고 서열번호: 30-3847의 핵염기 서열 중 임의의 것의 적어도 12, 적어도 13, 적어도 14, 적어도 15, 적어도 16, 적어도 17, 적어도 18, 적어도 19, 또는 적어도 20개의 연속적 핵염기를 포함하는 핵염기 서열을 가지고 있는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물.
12 내지 50개의 연결된 뉴클레오사이드로 이루어지고 적어도 8, 적어도 9, 적어도 10, 적어도 11, 적어도 12, 적어도 13, 적어도 14, 적어도 15, 적어도 16, 적어도 17, 적어도 18, 적어도 19, 또는 적어도 20개의 연속적 핵염기의 부분을 포함하는 핵염기 서열을 가지고 있는 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물이며, 상기 부분이 하기에 상보성인, 올리고머성 화합물:
서열번호: 2의 핵염기 18,633-18,658의 동일 길이 부분;
서열번호: 2의 핵염기 21,721-21,755의 동일 길이 부분;
서열번호: 2의 핵염기 27,963-28,016의 동일 길이 부분;
서열번호: 2의 핵염기 35,415-35,446의 동일 길이 부분;
서열번호: 2의 핵염기 77,221-77,264의 동일 길이 부분;
서열번호: 2의 핵염기 81,581-81,612 및/또는 87,838-87,869의 동일 길이 부분;
서열번호: 2의 핵염기 81,627-81,651의 동일 길이 부분;
서열번호: 2의 핵염기 82,058-82,081의 동일 길이 부분;
서열번호: 2의핵염기 82,180-82,220의 동일 길이 부분;
서열번호: 2의 핵염기 82,500-82,525의 동일 길이 부분;
서열번호: 2의 핵염기 91,038-91,067의 동일 길이 부분;
서열번호: 2의 핵염기 92,148-92,173의 동일 길이 부분;
서열번호: 2의 핵염기 98,186-98,220의 동일 길이 부분;
서열번호: 2의 핵염기 98,218-98,242의 동일 길이 부분;
서열번호: 2의 핵염기 99,199-99,223의 동일 길이 부분;
서열번호: 2의 핵염기 119,903-119,936의 동일 길이 부분; 또는
서열번호: 1의 핵염기 4,062-4,086의 동일 길이 부분.
서열번호: 2의 핵염기 18,633-18,658의 동일 길이 부분;
서열번호: 2의 핵염기 21,721-21,755의 동일 길이 부분;
서열번호: 2의 핵염기 27,963-28,016의 동일 길이 부분;
서열번호: 2의 핵염기 35,415-35,446의 동일 길이 부분;
서열번호: 2의 핵염기 77,221-77,264의 동일 길이 부분;
서열번호: 2의 핵염기 81,581-81,612 및/또는 87,838-87,869의 동일 길이 부분;
서열번호: 2의 핵염기 81,627-81,651의 동일 길이 부분;
서열번호: 2의 핵염기 82,058-82,081의 동일 길이 부분;
서열번호: 2의핵염기 82,180-82,220의 동일 길이 부분;
서열번호: 2의 핵염기 82,500-82,525의 동일 길이 부분;
서열번호: 2의 핵염기 91,038-91,067의 동일 길이 부분;
서열번호: 2의 핵염기 92,148-92,173의 동일 길이 부분;
서열번호: 2의 핵염기 98,186-98,220의 동일 길이 부분;
서열번호: 2의 핵염기 98,218-98,242의 동일 길이 부분;
서열번호: 2의 핵염기 99,199-99,223의 동일 길이 부분;
서열번호: 2의 핵염기 119,903-119,936의 동일 길이 부분; 또는
서열번호: 1의 핵염기 4,062-4,086의 동일 길이 부분.
제 1 항 내지 제 3 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가, 상기 변형된 올리고뉴클레오타이드의 전체 핵염기 서열에 걸쳐서 측정된 경우, 서열번호: 1 또는 서열번호: 2의 핵염기 서열에 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성인 핵염기 서열을 가지고 있는, 올리고머성 화합물.
제 1 항 내지 제 4 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 5 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 6 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 이환형 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 7 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 2'-4' 브릿지를 가지고 있는 이환형 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하며, 상기 2'-4' 브릿지가 -O-CH2-; 및 -O-CH(CH3)-로부터 선택되는, 올리고머성 화합물.
제 5 항 내지 제 8 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 비-이환형 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 9 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 2'-MOE 변형된 당 또는 2'-OMe 변형된 당을 포함하는 비-이환형 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 5 항 내지 제 10 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 당 대리물을 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 11 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 모폴리노 및 PNA로부터 선택된 당 대리물을 포함하는 적어도 하나의 변형된 뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 1 항 내지 제 12 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 하기를 포함하는 당 모티프를 가지며:
1-5개의 연결된 5'-영역 뉴클레오사이드로 이루어지는 5'-영역;
6-10개의 연결된 중심 영역 뉴클레오사이드로 이루어지는 중심 영역; 및
1-5개의 연결된 3'-영역 뉴클레오사이드로 이루어지는 3'-영역;
각각의 상기 5'-영역 뉴클레오사이드 및 각각의 상기 3'-영역 뉴클레오사이드가 변형된 당 모이어티를 포함하고 각각의 상기 중심 영역 뉴클레오사이드가 미변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머성 화합물.
1-5개의 연결된 5'-영역 뉴클레오사이드로 이루어지는 5'-영역;
6-10개의 연결된 중심 영역 뉴클레오사이드로 이루어지는 중심 영역; 및
1-5개의 연결된 3'-영역 뉴클레오사이드로 이루어지는 3'-영역;
각각의 상기 5'-영역 뉴클레오사이드 및 각각의 상기 3'-영역 뉴클레오사이드가 변형된 당 모이어티를 포함하고 각각의 상기 중심 영역 뉴클레오사이드가 미변형된 2'-데옥시리보실 당 모이어티를 포함하는, 올리고머성 화합물.
제 1 항 내지 제 13 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 인터뉴클레오사이드 연결기를 포함하는, 올리고머성 화합물.
제 14 항에 있어서, 상기 변형된 올리고뉴클레오타이드의 각 인터뉴클레오사이드 연결기가 변형된 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
제 14 항 또는 제 15 항에 있어서, 적어도 하나의 인터뉴클레오사이드 연결기가 포스포로티오에이트 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
제 14 항 또는 제 16 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 포스포디에스테르 인터뉴클레오사이드 연결기를 포함하는, 올리고머성 화합물.
제 14 항, 제 16 항, 또는 제 17 항 중 어느 하나의 항에 있어서, 각 인터뉴클레오사이드 연결기가 포스포디에스테르 인터뉴클레오사이드 연결기 또는 포스포로티오에이트 인터뉴클레오사이드 연결기인, 올리고머성 화합물.
제 1 항 내지 제 18 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는, 올리고머성 화합물.
제 19 항에 있어서, 상기 변형된 핵염기가 5-메틸 시토신인, 올리고머성 화합물.
제 1 항 내지 제 20 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 12-30, 12-22, 12-20, 14-20, 15-25, 16-20, 18-22 또는 18-20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머성 화합물.
제 1 항 내지 제 21 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 17 또는 20개의 연결된 뉴클레오사이드로 이루어지는, 올리고머성 화합물.
제 1 항 내지 제 22 항 중 어느 하나의 항에 있어서, 상기 변형된 올리고뉴클레오타이드로 이루어지는 올리고머성 화합물.
제 1 항 내지 제 22 항 중 어느 하나의 항에 있어서, 컨쥬게이트 모이어티 및 컨쥬게이트 링커를 포함하는 컨쥬게이트 그룹을 포함하는 올리고머성 화합물.
제 24 항에 있어서, 상기 컨쥬게이트 그룹이 1-3개의 GalNAc 리간드를 포함하는 GalNAc 클러스터를 포함하는, 올리고머성 화합물.
제 24 항 또는 제 25 항에 있어서, 상기 컨쥬게이트 링커가 단일 결합으로 이루어지는, 올리고머성 화합물.
제 25 항에 있어서, 상기 컨쥬게이트 링커가 절단가능한, 올리고머성 화합물.
제 27 항에 있어서, 상기 컨쥬게이트 링커가 1-3개의 링커-뉴클레오사이드를 포함하는, 올리고머성 화합물.
제 24 항 내지 제 28 항 중 어느 하나의 항에 있어서, 상기 컨쥬게이트 그룹이 상기 변형된 올리고뉴클레오타이드의 5'-말단에서 상기 변형된 올리고뉴클레오타이드에 부착되는, 올리고머성 화합물.
제 24 항 내지 제 28 항 중 어느 하나의 항에 있어서, 상기 컨쥬게이트 그룹이 상기 변형된 올리고뉴클레오타이드의 3'-말단에서 상기 변형된 올리고뉴클레오타이드에 부착되는, 올리고머성 화합물.
제 1 항 내지 제 30 항 중 어느 하나의 항에 있어서, 말단기를 포함하는 올리고머성 화합물.
제 1 항 내지 제 31 항 중 어느 하나의 항에 있어서, 단일가닥 올리고머성 화합물인 올리고머성 화합물.
제 1 항 내지 제 27 항 또는 제 29 항 내지 제 31 항 중 어느 하나의 항에 있어서, 링커-뉴클레오사이드를 포함하지 않는 올리고머성 화합물.
제 1 항 내지 제 31 항 또는 제 33 항 중 어느 하나의 항에 따른 올리고머성 화합물을 포함하는 올리고머성 듀플렉스.
제 1 항 내지 제 33 항 중 어느 하나의 항에 따른 올리고머성 화합물 또는 제 34 항에 따른 올리고머성 듀플렉스를 포함하거나 또는 이로 이루어지는 안티센스 화합물.
제 1 항 내지 제 33 항 중 어느 하나의 항에 따른 올리고머성 화합물 또는 제 34 항에 따른 올리고머성 듀플렉스 및 약제학적으로 허용가능한 담체 또는 희석제를 포함하는 약제학적 조성물.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 222)
또는 이의 염.
(서열번호: 222)
또는 이의 염.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 888)
또는 이의 염.
(서열번호: 888)
또는 이의 염.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 1431)
또는 이의 염.
(서열번호: 1431)
또는 이의 염.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3590)
또는 이의 염.
(서열번호: 3590)
또는 이의 염.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3385)
또는 이의 염.
(서열번호: 3385)
또는 이의 염.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 852)
또는 이의 염.
(서열번호: 852)
또는 이의 염.
제 37 항 내지 제 42 항 중 어느 하나의 항에 있어서, 상기 식의 나트륨염인, 변형된 올리고뉴클레오타이드.
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 222).
(서열번호: 222).
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 888).
(서열번호: 888).
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 1431).
(서열번호: 1431).
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3590).
(서열번호: 3590).
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 3385).
(서열번호: 3385).
하기 식에 따른 변형된 올리고뉴클레오타이드:
(서열번호: 852).
(서열번호: 852).
제 37 항 내지 제 49 항 중 어느 하나의 항에 따른 변형된 올리고뉴클레오타이드의 키랄 풍부 집단이며, 특정 입체화학적 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 50 항에 있어서, (Sp) 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 50 항 또는 제 51 항에 있어서, (Rp) 배치형태를 가지고 있는 적어도 하나의 특정 포스포로티오에이트 인터뉴클레오사이드 연결기를 포함하는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 50 항에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 특정, 독립적으로 선택된 입체화학적 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 53 항에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 (Sp) 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 53 항에 있어서, 각 포스포로티오에이트 인터뉴클레오사이드 연결기에서 (Rp) 배치형태를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 50 항 또는 제 53 항에 있어서, 5'에서 3' 방향으로, Sp-Sp-Rp 배치형태의 적어도 3개의 연속적 포스포로티오에이트 인터뉴클레오사이드 연결기를 가지고 있는 변형된 올리고뉴클레오타이드가 풍부한 키랄 풍부 집단.
제 37 항 내지 제 49 항 중 어느 하나의 항에 따른 변형된 올리고뉴클레오타이드의 집단이며, 상기 변형된 올리고뉴클레오타이드의 모든 포스포로티오에이트 인터뉴클레오사이드 연결기가 스테레오랜덤인, 집단.
제 37 항 내지 제 49 항 중 어느 하나의 항에 따른 변형된 올리고뉴클레오타이드 및 약제학적으로 허용가능한 희석제 또는 담체를 포함하는 약제학적 조성물.
제 58 항에 있어서, 상기 약제학적으로 허용가능한 희석제가 인공 뇌척수액인, 약제학적 조성물.
제 59 항에 있어서, 변형된 올리고뉴클레오타이드 및 인공 뇌척수액으로 본질적으로 이루어지는 약제학적 조성물.
제 36 항 또는 제 58 항 내지 제 60 항 중 어느 하나의 항에 따른 약제학적 조성물을 동물에 투여하는 단계를 포함하는 방법.
제 36 항 또는 제 58 항 내지 제 60 항 중 어느 하나의 항에 따른 약제학적 조성물의 치료적 유효량을 LRRK2와 연관된 질환을 가지고 있거나 발병의 위험에 처한 개체에 투여하는 단계; 및 그것에 의해 LRRK2와 연관된 질환을 치료하는 단계를 포함하는, LRRK2와 연관된 질환의 치료 방법.
제 62 항에 있어서, LRRK2와 연관된 질환이 신경퇴행성 질환인, 방법.
제 63 항에 있어서, 상기 신경퇴행성 질환이 파킨슨병인, 방법.
제 64 항에 있어서, 상기 신경퇴행성 질환의 적어도 하나의 징후 또는 특징이 개선되는, 방법.
제 65 항에 있어서, 상기 징후 또는 특징이 운동실조증, 신경병증, 및 응집체 형성 중 임의의 것인, 방법.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Ges mCeo Teo mCeo Aes Tds Ads Tds mCds Tds Ads Ads Ads Gds Ads mCeo mCeo Ges mCes Ae (서열번호: 222); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Tes mCeo Aeo mCeo mCes Ads mCds Ads Ads Ads mCds Tds mCds Ads Tds Geo Geo Aes mCes Te (서열번호: 888); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Aes mCeo mCeo mCeo Tes Tds Tds mCds mCds Ads Tds Gds Tds Gds Ads Aeo mCeo Aes Tes Te (서열번호: 1431); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Aes mCeo Geo mCeo Aes mCds Tds Tds Ads Ads mCds Ads Ads Tds Ads Teo mCeo Aes Tes Ae (서열번호: 3590); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: Aes Geo mCeo Aeo Aes Tds mCds Ads Tds Tds Gds Gds Tds Ads Gds mCeo Aeo Tes Aes mCe (서열번호: 3385); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
하기 식에 따른 변형된 올리고뉴클레오타이드를 포함하는 올리고머성 화합물: mCes Geo mCes Aes mCes Tds Tds Ads Ads mCds Ads Ads Tds Ads Tds mCes Aeo Tes Aes Te (서열번호: 852); 여기서,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 변형된 당,
d = 2'-데옥시리보오스 당,
s = 포스포로티오에이트 인터뉴클레오사이드 연결기, 및
o = 포스포디에스테르 인터뉴클레오사이드 연결기.
제 3 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 RNAi 화합물인, 올리고머성 화합물.
제 73 항에 있어서, 상기 RNAi 화합물이 ssRNA 또는 siRNA인, 올리고머성 화합물.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690790P | 2018-06-27 | 2018-06-27 | |
| US62/690,790 | 2018-06-27 | ||
| PCT/US2019/039558 WO2020006267A1 (en) | 2018-06-27 | 2019-06-27 | Compounds and methods for reducing lrrk2 expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210025055A true KR20210025055A (ko) | 2021-03-08 |
Family
ID=68987149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217001678A KR20210025055A (ko) | 2018-06-27 | 2019-06-27 | Lrrk2 발현 감소용 화합물 및 방법 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11332746B1 (ko) |
| EP (1) | EP3814503A4 (ko) |
| JP (2) | JP7315594B2 (ko) |
| KR (1) | KR20210025055A (ko) |
| CN (1) | CN112400019B (ko) |
| AR (1) | AR116102A1 (ko) |
| AU (1) | AU2019294838A1 (ko) |
| BR (1) | BR112020024564A2 (ko) |
| CA (1) | CA3104676A1 (ko) |
| CL (1) | CL2020003309A1 (ko) |
| CO (1) | CO2020015256A2 (ko) |
| CR (1) | CR20210044A (ko) |
| EA (1) | EA202190140A1 (ko) |
| IL (1) | IL279632A (ko) |
| JO (1) | JOP20200334A1 (ko) |
| MX (1) | MX2020013653A (ko) |
| PE (1) | PE20210518A1 (ko) |
| PH (1) | PH12021500003A1 (ko) |
| SG (1) | SG11202011864XA (ko) |
| UY (1) | UY38282A (ko) |
| WO (1) | WO2020006267A1 (ko) |
| ZA (1) | ZA202007444B (ko) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017120365A1 (en) | 2016-01-05 | 2017-07-13 | Ionis Pharmaceuticals, Inc. | Methods for reducing lrrk2 expression |
| WO2019140231A1 (en) | 2018-01-12 | 2019-07-18 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| WO2019169243A1 (en) | 2018-03-02 | 2019-09-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-beta precursor protein |
| MX2020013653A (es) | 2018-06-27 | 2021-03-02 | Ionis Pharmaceuticals Inc | Compuestos y metodos para la reduccion de la expresion de lrrk2. |
| WO2020006018A1 (en) | 2018-06-27 | 2020-01-02 | Bristol-Myers Squibb Company | Substituted naphthyridinone compounds useful as t cell activators |
| US20230357269A1 (en) | 2020-05-06 | 2023-11-09 | Les Laboratoires Servier | New macrocyclic lrrk2 kinase inhibitors |
| AU2021315992A1 (en) * | 2020-07-28 | 2023-02-09 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| TW202304935A (zh) | 2021-03-18 | 2023-02-01 | 法商施維雅藥廠 | 新穎的巨環lrrk2激酶抑制劑 |
| WO2022206816A1 (zh) * | 2021-03-30 | 2022-10-06 | 南京大学 | 一种用于治疗帕金森的rna质粒递送系统 |
| KR102644654B1 (ko) | 2021-04-19 | 2024-03-07 | 노보 노르디스크 에이/에스 | 핵 수용체 서브패밀리 1 그룹 h 구성원 3(nr1h3) 발현을 억제하기 위한 조성물 및 방법 |
| WO2022226018A1 (en) * | 2021-04-20 | 2022-10-27 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Malignant mesothelioma susceptibility as a result of germline leucine-rich repeat kinase 2 (lrrk2) alterations |
| EP4363588A1 (en) * | 2021-06-29 | 2024-05-08 | Alnylam Pharmaceuticals Inc. | Leucine-rich repeat kinase 2 (lrrk2) irna agent compositions and methods of use thereof |
| WO2023144263A1 (en) * | 2022-01-26 | 2023-08-03 | Syddansk Universitet | Allele specific splice switching oligonucleotides targeting pseudoexons |
Family Cites Families (185)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4476301A (en) | 1982-04-29 | 1984-10-09 | Centre National De La Recherche Scientifique | Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon |
| DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| US5118800A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | Oligonucleotides possessing a primary amino group in the terminal nucleotide |
| USRE34036E (en) | 1984-06-06 | 1992-08-18 | National Research Development Corporation | Data transmission using a transparent tone-in band system |
| US5550111A (en) | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US5367066A (en) | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
| FR2575751B1 (fr) | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| EP0260032B1 (en) | 1986-09-08 | 1994-01-26 | Ajinomoto Co., Inc. | Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| DE3851889T2 (de) | 1987-06-24 | 1995-04-13 | Florey Howard Inst | Nukleosid-derivate. |
| US4924624A (en) | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
| US5188897A (en) | 1987-10-22 | 1993-02-23 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated 2',5'-phosphorothioate oligoadenylates |
| JP3019994B2 (ja) | 1987-11-30 | 2000-03-15 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 新規なオリゴデオキシヌクレオチド、それを使用した標的遺伝子の発現をブロックする方法、及び新規なオリゴデオキシヌクレオチド並びにそれを使用した標的遺伝子の発現を阻止する方法 |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| EP0406309A4 (en) | 1988-03-25 | 1992-08-19 | The University Of Virginia Alumni Patents Foundation | Oligonucleotide n-alkylphosphoramidates |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5175273A (en) | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
| US5194599A (en) | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5134066A (en) | 1989-08-29 | 1992-07-28 | Monsanto Company | Improved probes using nucleosides containing 3-dezauracil analogs |
| US5591722A (en) | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| US5399676A (en) | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US5721218A (en) | 1989-10-23 | 1998-02-24 | Gilead Sciences, Inc. | Oligonucleotides with inverted polarity |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| ATE190981T1 (de) | 1989-10-24 | 2000-04-15 | Isis Pharmaceuticals Inc | 2'-modifizierte nukleotide |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5587361A (en) | 1991-10-15 | 1996-12-24 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US7101993B1 (en) | 1990-01-11 | 2006-09-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides containing 2′-O-modified purines |
| US6005087A (en) | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
| US5859221A (en) | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5457191A (en) | 1990-01-11 | 1995-10-10 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5587470A (en) | 1990-01-11 | 1996-12-24 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
| US5623065A (en) | 1990-08-13 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Gapped 2' modified oligonucleotides |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| US5220007A (en) | 1990-02-15 | 1993-06-15 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of RNA and production of encoded polypeptides |
| US5321131A (en) | 1990-03-08 | 1994-06-14 | Hybridon, Inc. | Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
| EP0455905B1 (en) | 1990-05-11 | 1998-06-17 | Microprobe Corporation | Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides |
| US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
| US5223618A (en) | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5541307A (en) | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| JPH0874B2 (ja) | 1990-07-27 | 1996-01-10 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| KR100211552B1 (ko) | 1990-08-03 | 1999-08-02 | 디. 꼬쉬 | 유전자 발현 억제용 화합물 및 방법 |
| US5177196A (en) | 1990-08-16 | 1993-01-05 | Microprobe Corporation | Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof |
| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
| US5561225A (en) | 1990-09-19 | 1996-10-01 | Southern Research Institute | Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages |
| CA2092002A1 (en) | 1990-09-20 | 1992-03-21 | Mark Matteucci | Modified internucleoside linkages |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5948903A (en) | 1991-01-11 | 1999-09-07 | Isis Pharmaceuticals, Inc. | Synthesis of 3-deazapurines |
| US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| US7015315B1 (en) | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
| US5571799A (en) | 1991-08-12 | 1996-11-05 | Basco, Ltd. | (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response |
| ES2103918T3 (es) | 1991-10-17 | 1997-10-01 | Ciba Geigy Ag | Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios. |
| US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| EP1256589A3 (en) | 1991-11-26 | 2003-09-17 | Isis Pharmaceuticals, Inc. | Oligomers containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5359044A (en) | 1991-12-13 | 1994-10-25 | Isis Pharmaceuticals | Cyclobutyl oligonucleotide surrogates |
| US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| FR2687679B1 (fr) | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | Oligothionucleotides. |
| US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| EP0577558A2 (de) | 1992-07-01 | 1994-01-05 | Ciba-Geigy Ag | Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte |
| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| GB9304620D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Compounds |
| DK0691968T3 (da) | 1993-03-30 | 1998-02-23 | Sanofi Sa | Acykliske nukleosid-analoge og oligonukleotidsekvenser indeholdende disse |
| JPH08508491A (ja) | 1993-03-31 | 1996-09-10 | スターリング ウインスロップ インコーポレイティド | ホスホジエステル結合をアミド結合に置き換えたオリゴヌクレオチド |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5457187A (en) | 1993-12-08 | 1995-10-10 | Board Of Regents University Of Nebraska | Oligonucleotides containing 5-fluorouracil |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| EP0733059B1 (en) | 1993-12-09 | 2000-09-13 | Thomas Jefferson University | Compounds and methods for site-directed mutations in eukaryotic cells |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| US5627053A (en) | 1994-03-29 | 1997-05-06 | Ribozyme Pharmaceuticals, Inc. | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
| US5625050A (en) | 1994-03-31 | 1997-04-29 | Amgen Inc. | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics |
| US5646269A (en) | 1994-04-28 | 1997-07-08 | Gilead Sciences, Inc. | Method for oligonucleotide analog synthesis |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| US5597909A (en) | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
| US5652356A (en) | 1995-08-17 | 1997-07-29 | Hybridon, Inc. | Inverted chimeric and hybrid oligonucleotides |
| US5994517A (en) | 1995-11-22 | 1999-11-30 | Paul O. P. Ts'o | Ligands to enhance cellular uptake of biomolecules |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| USRE44779E1 (en) | 1997-03-07 | 2014-02-25 | Santaris Pharma A/S | Bicyclonucleoside and oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US6300319B1 (en) | 1998-06-16 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Targeted oligonucleotide conjugates |
| US6043352A (en) | 1998-08-07 | 2000-03-28 | Isis Pharmaceuticals, Inc. | 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides |
| US7053207B2 (en) | 1999-05-04 | 2006-05-30 | Exiqon A/S | L-ribo-LNA analogues |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US6426220B1 (en) | 2000-10-30 | 2002-07-30 | Isis Pharmaceuticals, Inc. | Antisense modulation of calreticulin expression |
| WO2002043771A2 (en) | 2000-12-01 | 2002-06-06 | Cell Works Inc. | Conjugates of glycosylated/galactosylated peptide |
| US20030175906A1 (en) | 2001-07-03 | 2003-09-18 | Muthiah Manoharan | Nuclease resistant chimeric oligonucleotides |
| US20030158403A1 (en) | 2001-07-03 | 2003-08-21 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| US7696345B2 (en) | 2002-11-05 | 2010-04-13 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| AU2003291755A1 (en) | 2002-11-05 | 2004-06-07 | Isis Pharmaceuticals, Inc. | Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use |
| PT2284266E (pt) | 2002-11-14 | 2013-12-17 | Thermo Fisher Scient Biosciences Inc | Siarn contra tp53 |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| AU2003224132A1 (en) | 2003-04-24 | 2004-11-19 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
| WO2005027962A1 (en) | 2003-09-18 | 2005-03-31 | Isis Pharmaceuticals, Inc. | 4’-thionucleosides and oligomeric compounds |
| DK1802749T3 (da) | 2004-10-21 | 2012-11-26 | Mayo Foundation | KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser |
| US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| PL1984381T3 (pl) | 2006-01-27 | 2011-03-31 | Isis Pharmaceuticals Inc | Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych |
| US7569686B1 (en) | 2006-01-27 | 2009-08-04 | Isis Pharmaceuticals, Inc. | Compounds and methods for synthesis of bicyclic nucleic acid analogs |
| WO2007124096A2 (en) | 2006-04-21 | 2007-11-01 | The Trustees Of Columbia University In The City Of New York | Lrrk2 regulaton of neuronal process morphology |
| CA2682320A1 (en) * | 2006-05-01 | 2007-11-08 | Aarhus Universitet | An animal model and a method for producing an animal model |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| JP5441688B2 (ja) | 2006-05-11 | 2014-03-12 | アイシス ファーマシューティカルズ， インコーポレーテッド | ５’修飾二環式核酸類似体 |
| ES2526295T5 (es) | 2006-10-18 | 2021-05-04 | Ionis Pharmaceuticals Inc | Compuestos antisentido |
| WO2008091799A2 (en) | 2007-01-22 | 2008-07-31 | The Trustees Of Columbia University In The City Of New York | Cell-based methods for identifying inhibitors of parkinson's disease-associated lrrk2 mutants |
| EP2125852B1 (en) | 2007-02-15 | 2016-04-06 | Ionis Pharmaceuticals, Inc. | 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom |
| WO2008150729A2 (en) | 2007-05-30 | 2008-12-11 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| EP2176280B2 (en) | 2007-07-05 | 2015-06-24 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| WO2009023855A2 (en) | 2007-08-15 | 2009-02-19 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
| US8546556B2 (en) | 2007-11-21 | 2013-10-01 | Isis Pharmaceuticals, Inc | Carbocyclic alpha-L-bicyclic nucleic acid analogs |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| WO2009099991A2 (en) | 2008-01-31 | 2009-08-13 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
| WO2009100320A2 (en) | 2008-02-07 | 2009-08-13 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| WO2010036698A1 (en) | 2008-09-24 | 2010-04-01 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
| EP2462153B1 (en) | 2009-08-06 | 2015-07-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| CN102482670B (zh) * | 2009-08-21 | 2018-06-15 | 库尔纳公司 | 通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病 |
| CA2782207A1 (en) | 2009-11-30 | 2011-06-03 | 23Andme, Inc. | Polymorphisms associated with parkinson's disease |
| GB201004475D0 (en) | 2010-03-17 | 2010-05-05 | Isis Innovation | Gene silencing |
| US10913767B2 (en) | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| AU2011302152B2 (en) | 2010-09-15 | 2015-06-11 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| WO2012109395A1 (en) | 2011-02-08 | 2012-08-16 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| WO2012118796A1 (en) | 2011-02-28 | 2012-09-07 | The Schepens Eye Research Institute, Inc. | Compositions for controlling neuronal outgrowth |
| GB201105137D0 (en) * | 2011-03-28 | 2011-05-11 | Isis Innovation | Therapeutic molecules for use in the suppression of Parkinson's disease |
| CN106912197B (zh) | 2011-04-28 | 2022-01-25 | 生命技术公司 | 用于多重pcr的方法和组合物 |
| US10023861B2 (en) | 2011-08-29 | 2018-07-17 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| EP3336189A1 (en) | 2012-04-20 | 2018-06-20 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| JP2016528873A (ja) | 2012-05-16 | 2016-09-23 | ラナ セラピューティクス インコーポレイテッド | 遺伝子発現を調節するための組成物及び方法 |
| WO2014059353A2 (en) | 2012-10-11 | 2014-04-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleosides and uses thereof |
| AU2013346767B2 (en) | 2012-11-15 | 2019-04-11 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| AU2014259755B2 (en) | 2013-05-01 | 2018-08-30 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating apolipoprotein (a) expression |
| TW202246503A (zh) * | 2013-07-19 | 2022-12-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| AU2015240761B2 (en) | 2014-04-01 | 2019-09-12 | Biogen Ma Inc. | Compositions for modulating SOD-1 expression |
| PL3234134T3 (pl) | 2014-12-17 | 2020-12-28 | Proqr Therapeutics Ii B.V. | Ukierunkowana edycja rna |
| MA41271A (fr) | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| KR20180030201A (ko) | 2015-07-23 | 2018-03-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화합물 |
| EP3377629B1 (en) | 2015-11-18 | 2023-07-05 | Rosalind Franklin University of Medicine and Science | Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease |
| WO2017120365A1 (en) * | 2016-01-05 | 2017-07-13 | Ionis Pharmaceuticals, Inc. | Methods for reducing lrrk2 expression |
| US20180179594A1 (en) | 2016-10-31 | 2018-06-28 | Parkinson's Institute | Multiple system atrophy and the treatment thereof |
| JOP20190104A1 (ar) * | 2016-11-10 | 2019-05-07 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن atxn3 |
| WO2019118325A1 (en) | 2017-12-11 | 2019-06-20 | Rosalind Franklin University Of Medicine And Science | Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease |
| MX2020013653A (es) | 2018-06-27 | 2021-03-02 | Ionis Pharmaceuticals Inc | Compuestos y metodos para la reduccion de la expresion de lrrk2. |
-
2019
- 2019-06-27 MX MX2020013653A patent/MX2020013653A/es unknown
- 2019-06-27 EP EP19827230.4A patent/EP3814503A4/en active Pending
- 2019-06-27 AU AU2019294838A patent/AU2019294838A1/en active Pending
- 2019-06-27 SG SG11202011864XA patent/SG11202011864XA/en unknown
- 2019-06-27 JO JOP/2020/0334A patent/JOP20200334A1/ar unknown
- 2019-06-27 US US16/972,822 patent/US11332746B1/en active Active
- 2019-06-27 PE PE2020002146A patent/PE20210518A1/es unknown
- 2019-06-27 WO PCT/US2019/039558 patent/WO2020006267A1/en active Application Filing
- 2019-06-27 UY UY0001038282A patent/UY38282A/es unknown
- 2019-06-27 BR BR112020024564-0A patent/BR112020024564A2/pt unknown
- 2019-06-27 JP JP2020571686A patent/JP7315594B2/ja active Active
- 2019-06-27 CA CA3104676A patent/CA3104676A1/en active Pending
- 2019-06-27 CN CN201980041574.4A patent/CN112400019B/zh active Active
- 2019-06-27 CR CR20210044A patent/CR20210044A/es unknown
- 2019-06-27 EA EA202190140A patent/EA202190140A1/ru unknown
- 2019-06-27 KR KR1020217001678A patent/KR20210025055A/ko not_active Application Discontinuation
- 2019-07-02 AR ARP190101869A patent/AR116102A1/es unknown
-
2020
- 2020-11-30 ZA ZA2020/07444A patent/ZA202007444B/en unknown
- 2020-12-04 CO CONC2020/0015256A patent/CO2020015256A2/es unknown
- 2020-12-18 CL CL2020003309A patent/CL2020003309A1/es unknown
- 2020-12-21 IL IL279632A patent/IL279632A/en unknown
-
2021
- 2021-01-07 PH PH12021500003A patent/PH12021500003A1/en unknown
-
2022
- 2022-04-04 US US17/712,822 patent/US11873495B2/en active Active
-
2023
- 2023-07-13 JP JP2023114861A patent/JP2023134635A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020006267A1 (en) | 2020-01-02 |
| IL279632A (en) | 2021-03-01 |
| JOP20200334A1 (ar) | 2020-12-20 |
| SG11202011864XA (en) | 2020-12-30 |
| AU2019294838A1 (en) | 2021-01-07 |
| AR116102A1 (es) | 2021-03-31 |
| UY38282A (es) | 2019-12-31 |
| CN112400019B (zh) | 2024-05-07 |
| CR20210044A (es) | 2021-06-24 |
| EP3814503A1 (en) | 2021-05-05 |
| EP3814503A4 (en) | 2023-03-15 |
| CA3104676A1 (en) | 2020-01-02 |
| CN112400019A (zh) | 2021-02-23 |
| TW202035691A (zh) | 2020-10-01 |
| CO2020015256A2 (es) | 2020-12-21 |
| EA202190140A1 (ru) | 2021-05-20 |
| JP7315594B2 (ja) | 2023-07-26 |
| BR112020024564A2 (pt) | 2021-04-06 |
| JP2023134635A (ja) | 2023-09-27 |
| PE20210518A1 (es) | 2021-03-17 |
| PH12021500003A1 (en) | 2021-09-13 |
| JP2021530204A (ja) | 2021-11-11 |
| MX2020013653A (es) | 2021-03-02 |
| US11873495B2 (en) | 2024-01-16 |
| CL2020003309A1 (es) | 2021-07-19 |
| US20230114930A1 (en) | 2023-04-13 |
| US11332746B1 (en) | 2022-05-17 |
| ZA202007444B (en) | 2023-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102643936B1 (ko) | 병태 및 질환 치료용 안티센스 올리고머 | |
| AU2020203573B2 (en) | Oligonucleotides for inducing paternal UBE3A expression | |
| AU2017200759B2 (en) | Modulation of androgen receptor expression | |
| KR20210025055A (ko) | Lrrk2 발현 감소용 화합물 및 방법 | |
| KR20200140805A (ko) | Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 | |
| KR101778036B1 (ko) | 전립선암 마커로서의 포스포디에스테라제 4ｄ7 | |
| RU2724527C2 (ru) | Композиции и способы модулирования экспрессии рецептора гормона роста | |
| KR102110469B1 (ko) | 악성의 호르몬 민감성 전립선 암에 대한 마커로서의 포스포디에스테라제 4ｄ7 | |
| KR102236784B1 (ko) | 성장 호르몬 수용체의 조절인자 | |
| KR20210027384A (ko) | Scn9a 발현을 조절하기 위한 올리고뉴클레오티드 | |
| KR101621273B1 (ko) | 카텝신 ｃ의 용도 | |
| KR20200079304A (ko) | Snca 발현을 감소시키기 위한 화합물 및 방법 | |
| KR20220113743A (ko) | 병태 및 질환의 치료를 위한 안티센스 올리고머 | |
| KR20210065125A (ko) | 인간의 앤젤만 증후군에서 부계 ube3a 유전자 발현을 복원하기 위한 조성물 및 방법 | |
| CN101151371B (zh) | 治疗中的逆转录转座子抑制 | |
| KR20230043914A (ko) | App 발현을 감소시키기 위한 화합물 및 방법 | |
| KR20210144822A (ko) | Ube3a-ats를 조절하기 위한 화합물 및 방법 | |
| KR20230074214A (ko) | 지방간 질환의 치료 방법 | |
| KR20230048052A (ko) | Scn2a를 조절하는 화합물 및 방법 | |
| KR20230005933A (ko) | Atxn1을 조정하는 화합물 및 방법 | |
| KR100998272B1 (ko) | 단백질 지령부위내 단반복 염기서열을 갖는 신규 유전자 | |
| TW202305132A (zh) | 用於抑制α-突觸核蛋白表達之反義寡核苷酸 | |
| CN111556894A (zh) | 用于调控gsk3b表达的寡核苷酸 | |
| KR20130024138A (ko) | 듀센형 근이영양증 진단용 마이크로어레이 및 키트 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal |