KR20230005933A - Atxn1을 조정하는 화합물 및 방법 - Google Patents
Atxn1을 조정하는 화합물 및 방법 Download PDFInfo
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- KR20230005933A KR20230005933A KR1020227041965A KR20227041965A KR20230005933A KR 20230005933 A KR20230005933 A KR 20230005933A KR 1020227041965 A KR1020227041965 A KR 1020227041965A KR 20227041965 A KR20227041965 A KR 20227041965A KR 20230005933 A KR20230005933 A KR 20230005933A
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- modified oligonucleotide
- modified
- seq
- oligomeric compound
- oligomeric
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Abstract
요약서
세포 또는 대상체에서 ATXN1 RNA의 양 또는 이의 활성 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공하며, 그리고 특정 경우들에서 이들 세포 또는 대상체에서 ATXN1 양의 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공한다. 이러한 화합물들, 방법들, 및 약제학적 조성물들은 신경퇴행성 질환의 적어도 하나의 증상 또는 특징 개선에 유용하다. 이러한 증상 및 특징에는 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이 내포된다. 이러한 신경퇴행성 질환에는 제1형 척수소뇌성 운동실조가 내포된다.
세포 또는 대상체에서 ATXN1 RNA의 양 또는 이의 활성 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공하며, 그리고 특정 경우들에서 이들 세포 또는 대상체에서 ATXN1 양의 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공한다. 이러한 화합물들, 방법들, 및 약제학적 조성물들은 신경퇴행성 질환의 적어도 하나의 증상 또는 특징 개선에 유용하다. 이러한 증상 및 특징에는 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이 내포된다. 이러한 신경퇴행성 질환에는 제1형 척수소뇌성 운동실조가 내포된다.
Description
서열 목록
본 출원은 전자 형식의 서열 목록이 함께 제출되었다. 이 서열 목록은 2021 년 4 월 26 일에 생성된 BIOL0355WOSEQ_ST25.txt라는 파일로 제공되며, 크기는 1.32 MB이다. 서열 목록의 전자 형식의 정보는 전체가 참고자료로 본원에 편입된다.
분야
세포 또는 대상체에서 ATXN1 RNA의 양 또는 이의 활성 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공하며, 그리고 특정 경우들에서, 이들 세포 또는 대상체에서 ATXN1 단백질 양의 감소를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공한다. 이러한 화합물들, 방법들, 및 약제학적 조성물들은 신경퇴행성 질환의 적어도 하나의 증상 또는 특징 개선에 유용하다. 이러한 증상 및 특징에는 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이 내포된다. 이러한 신경퇴행성 질환에는 제1형 척수소뇌성 운동실조가 내포된다.
배경
제1형 척수소뇌성 운동실조 (SCA1)는 전 세계적으로 100,000명 당 1~2명의 개체에게 영향을 미치는 진행성, 치명적 신경퇴행성 장애다. SCA1은 Ataxin-1을 인코드하는 유전자, ATXN1의 코딩 영역에서 확장된 CAG 반복부에 의해 야기된다. 돌연변이체 Ataxin-1 단백질이 축적되면 푸르키네(Purkinje) 세포 및 뇌간(brainstem) 핵의 퇴행으로 이어진다. SCA1의 증상 및 특징에는 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이 내포된다 (가령, Ju, H., Kokubu, H., 그리고 Lim, J., Mol. Neurobiol. 50:866-874, 2014; Ortiz, J. P., Orr, H. T., in Polyglutamine Disorders, 
, C. 그리고 Almeida, L., eds., Advances in Exp. Med. And Biol., 1049: 135-145, 2018 참고).
SCA1에 대한 특이적 치료요법은 없으며, 현재 치료는 개별 증상에 대한 지지적 치료(supportive treatments)로 국한된다.
현재, 신경퇴행성 질환, 이를 테면, SCA1을 치료하기 위한 수용가능한 옵션이 부족하다. 따라서, 이러한 질환들의 치료를 위한 화합물들, 방법들, 및 약제학적 조성물들을 제공하는 것이 본원의 목적이다.
발명의 요약
본원에서 ATXN1 RNA의 양 또는 이의 활성 감소를 위한 화합물들, 방법들 및 약제학적 조성물들을 제공하며, 특정 구체예들에서 세포 또는 대상체에서 ATXN1 단백질의 발현 감소를 위한 화합물들, 방법들 및 약제학적 조성물들을 제공한다. 특정 구체예들에서, 상기 대상체는 신경퇴행성 질환을 갖는다. 특정 구체예들에서, 상기 대상체는 제1형 척수소뇌성 운동실조 (SCA1)를 갖는다. 특정 구체예들에서, ATXN1 RNA의 양 또는 이의 활성 감소에 유용한 화합물들은 올리고머 화합물들이다. 특정 구체예들에서, ATXN1 RNA의 양 또는 이의 활성 감소에 유용한 화합물들은 변형된 올리고뉴클레오티드이다. 특정 구체예들에서, ATXN1 단백질의 발현 감소에 유용한 화합물들은 올리고머 화합물들이다. 특정 구체예들에서, ATXN1 단백질의 발현 감소에 유용한 화합물들은 변형된 올리고뉴클레오티드이다.
신경퇴행성 질환의 적어도 하나의 증상 또는 특징의 개선에 유용한 방법들이 또한 제공된다. 특정 구체예들에서, 상기 신경퇴행성 질환은 제1형 척수소뇌성 운동실조이다. 특정 구체예들에서, 상기 증상 및 특징에는 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이 내포된다.
발명의 상세한 설명
선행된 일반적인 설명 및 이어지는 상세한 설명은 모두 예시와 설명을 위한 것이며, 이에 국한되지 않는 것으로 이해되어야 한다. 이하에서, 단수의 사용에는 다른 명시적 언급이 없는 한, 복수가 내포된다. 본원에서 이용된 바와 같이, "또는"의 사용은 명시적으로 다른 언급이 없는 한, "및/또는"를 의미한다. 더욱이, "~를 내포하는"이라는 용어와 "~을 내포한다" 및 "내포된"과 같은 기타 형태의 사용에 제한이 있는 것은 아니다. 또한, "요소(element)" 또는 "성분(component)"과 같은 용어는, 달리 구체적으로 언급되지 않은 한, 하나를 초과하는 소단위를 포함하는 하나의 단위 및 요소 및 성분을 포함하는 요소 및 성분 둘 모두를 포괄한다.
본 명세서에서 사용된 섹션 제목은 오로지 구획을 구분하려는 목적을 위함이며, 서술된 주제를 제한하는 것으로 간주되어서는 안된다. 특허, 특허 출원, 공개된 특허 출원, 문헌, 책, 협정, 그리고 GenBank, ENSEMBL, 및 NCBI 참조 서열 기록을 비롯한, 그러나 이에 국한되지 않은 본 명세서에서 언급된 모든 서류, 또는 서류의 일부는 본 명세서에서 논의된 일부로써 이의 전문이 본 명세서의 참고자료에 명시적으로 편입된다.
정의
명시적으로 다른 언급이 없는 한, 본원에 기재된 분석 화학, 합성 유기 화학, 및 의약 및 제약 화학과 관련하여 사용된 명명법 및 절차 및 기술은 당업계에 잘 알려져 있고 통상적으로 사용되는 것들이다. 허용되는 경우, 모든 특허, 출원, 공개된 출원 및 기타 간행물 및 본 명세서 내용 전반에 걸쳐 언급된 기타 데이터는 그 전체가 본원의 참조자료에 편입된다.
달리 명시되지 않는 한, 다음 용어의 의미는 다음과 같다:
정의
본원에서 이용된 바와 같이, "2'-데옥시뉴클레오시드"는 2'-H(H) 데옥시푸라노실 당 모이어티를 포함하는 뉴클레오시드를 의미한다. 특정 구체예들에서, 2'-데옥시뉴클레오시드는 2'-β-D-데옥시뉴클레오시드이며, 2'-β-D-데옥시리보실 당 모이어티를 포함하고, 이것은 자연 발생적 데옥시리보핵산 (DNA)에서 발견되는 β-D 리보실 배위를 갖는다. 특정 구체예들에서, 2'-데옥시뉴클레오시드는 변형된 핵염기를 포함할 수 있거나, 또는 RNA 핵염기 (우라실)를 포함할 수 있다.
본원에서 이용된 바와 같이, "2'-MOE"는 푸라노실 당 모이어티의 2'-OH 기 위치에 2'-OCH2CH2OCH3 기가 있음을 의미한다. "2'-MOE 당 모이어티"란 푸라노실 당 모이어티의 2'-OH 기 위치에 2'-OCH2CH2OCH3 기를 갖는 당 모이어티다. 달리 명시되지 않는 한, 2'-MOE 당 모이어티는 β-D-리보실 배위로 존재한다. "MOE"란 O-메톡시에틸을 의미한다.
본원에서 이용된 바와 같이, "2'-MOE 뉴클레오시드"는 2'-MOE 당 모이어티를 포함하는 뉴클레오시드를 의미한다.
본원에서 이용된 바와 같이, "2'-OMe"란 푸라노실 당 모이어티의 2'-OH 기 위치에 2'-OCH3 기를 의미한다. "2'-O-메틸 당 모이어티" 또는 "2'-OMe 당 모이어티"란 푸라노실 당 모이어티의 2'-OH 기 위치에 2'-OCH3 기를 갖는 당 모이어티를 의미한다. 달리 명시되지 않는 한, 2'-OMe 당 모이어티는 β-D-리보실 배위로 존재한다.
본원에서 이용된 바와 같이, "2'-OMe 뉴클레오시드"란 2'-OMe 당 모이어티를 포함하는 뉴클레오시드를 의미한다.
본원에서 이용된 바와 같이, "2'-치환된 뉴클레오시드"란 2'-치환된 당 모이어티를 포함하는 뉴클레오시드를 의미한다. 본원에서 이용된 바와 같이, 당 모이어티의 언급에서 "2'-치환된"이란 H 또는 OH를 제외한, 적어도 하나의 2'-치환기를 포함하는 당 모이어티를 의미한다.
본원에서 이용된 바와 같이, "5-메틸 시토신"은 5 위치에 부착된 메틸기로 변형된 시토신을 의미한다. 5-메틸 시토신은 변형된 핵염기이다.
본원에서 이용된 바와 같이, "~를 투여하다"란 약제학적 제제를 대상체에게 제공한다는 것을 의미한다.
본원에서 이용된 바와 같이, "안티센스(antisense) 활성"이란 안티센스 화합물이 이의 표적 핵산에 혼성화에 기여하는 임의의 검출가능한 및/또는 측정가능한 변화를 의미한다. 특정 구체예들에서, 안티센스 활성이란 이 안티센스 화합물의 부재 시, 표적 핵산 수준 또는 표적 단백질 수준과 비교하여, 표적 핵산 또는 이러한 표적 핵산에 의해 인코드된 단백질의 양 또는 발현이 감소하는 것이다.
본원에서 이용된 바와 같이, "안티센스 화합물"은 적어도 하나의 안티센스 활성을 이룰 수 있는 올리고머 화합물을 의미한다.
본원에서 이용된 바와 같이, 치료 관련하여 "개선하다"란 해당 치료가 없을 때 동일한 증상과 관련하여 적어도 하나의 증상에서 개선을 의미한다. 특정 구체예들에서, 개선이란 증상의 심각성 또는 빈도의 감소, 또는 증상의 심각성 또는 빈도의 발병 지연 또는 진행의 둔화이다. 이러한 증상 및 특징은 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망이다.
본원에서 이용된 바와 같이, "이환(bicyclic) 뉴클레오시드" 또는 "BNA"란 이환 당 모이어티를 포함하는 뉴클레오시드를 의미한다.
본원에서 이용된 바와 같이, "이환 당(bicyclic sugar)" 또는 "이환 당 모이어티(bicyclic sugar moiety)"란 두 개 고리를 포함하는 변형된 당 모이어티를 의미하며, 이때 제 2 고리는 제 1 고리의 원자들중 두 개를 연결시키는 다리를 통하여 형성되고, 이로써 이환 구조가 형성된다. 특정 구체예들에서, 상기 이환 당 모이어티의 제 1 고리는 푸라노실 모이어티이다. 특정 구체예들에서, 상기 푸라노실 당 모이어티는 리보실 모이어티이다. 특정 구체예들에서, 상기 이환 당 모이어티는 푸라노실 모이어티를 포함하지 않는다.
본원에서 이용된 바와 같이, "절단가능한(cleavable) 모이어티"란 생리학적 조건 하에서, 예를 들면, 세포, 동물, 또는 인간 내부에서 절단되는 결합 또는 원자들의 그룹을 의미한다.
본원에서 이용된 바와 같이, 올리고뉴클레오티드 관련하여 "상보성(complementary)"이란 해당 올리고뉴클레오티드의 핵 염기의 적어도 70% 또는 이의 하나 또는 그 이상의 부분들과 또다른 핵산의 핵염기들 또는 이의 하나 또는 그 이상의 부분들이 해당 올리고뉴클레오티드의 핵염기 서열과 다른 핵산이 서로 반대 방향으로 정렬될 때, 수소결합을 형성할 수 있음을 의미한다. 본원에서 이용된 바와 같이, 상보성 핵염기란 서로 수소 결합을 형성할 수 있는 핵염기를 의미한다. 상보성 핵염기 쌍에는 데닌 (A)과 티민 (T), 아데닌 (A)과 우라실 (U), 시토신 (C)과 구아닌 (G), 5-메틸 시토신 (mC)과 구아닌 (G)이 내포된다 상보성 올리고뉴클레오티드 및/또는 표적 핵산은 뉴클레오시드에서 핵염기 상보성을 가질 필요는 없다. 오히려, 일부 미스매치(mismatches)가 용인된다. 본원에서 이용된 바와 같이, 올리고뉴클레오티드, 또는 이의 부분 관련하여, "완전한(fully) 상보성" 또는 "100% 상보성"이란 해당 올리고뉴클레오티드, 또는 이의 일부분이 또다른 올리고뉴클레오티드에 상보성이거나, 또는 이들 두 올리고뉴클레오티드의 더 짧은 핵염기에서 표적 핵산에 상보성이거나, 또는 올리고뉴클레오티드가 동일한 길이일 경우 각 뉴클레오시드에서 표적 핵산에 상보성임을 의미한다.
본원에서 이용된 바와 같이, "콘쥬게이트(conjugate) 기"란 올리고뉴클레오티드에 직접적으로 또는 간접적으로 부착된 원자 기를 의미한다. 콘쥬게이트 기들에는 콘쥬게이트 모이어티와 올리고뉴클레오티드에 해당 콘쥬게이트 모이어티를 부착시키는 콘쥬게이트 링커가 내포된다.
본원에서 이용된 바와 같이, "콘쥬게이트 링커(linker)"란 콘쥬게이트 모이어티를 올리고뉴클레오티드에 연결시키는 적어도 하나의 결합을 포함하는 원자 기 또는 단일 결합을 의미한다.
본원에서 이용된 바와 같이, "콘쥬게이트 모이어티(moiety)"란 콘쥬게이트 링커를 통하여 올리고뉴클레오티드에 부착된 원자 기를 의미한다.
본원에서 이용된 바와 같이, 올리고뉴클레오티드의 내용에서 "연접한(contiguous)"이란 서로 바로 연접한 뉴클레오시드, 핵염기, 당 모이어티, 또는 뉴클레오시드간 링키지를 지칭한다. 예를 들면, "연접한 핵염기(nucleobases)"란 서열에서 서로에 바로 인접한 핵염기를 의미한다.
본원에서 이용된 바와 같이, "cEt"이란 리보실 당 모이어티의 2'OH-기 위치에 4'에서 2'로의 다리를 의미하고, 이때 이 다리는 식 4'-CH(CH3)-O-2'을 갖고, 이때 이 다리의 메틸기는 S 배위로 존재한다. "cEt 당 모이어티"는 리보실 당 모이어티의 2'OH-기 위치에 4'에서 2'로의 다리를 갖는 이환 당 모이어티이며, 이때 이 다리는 식 4'-CH(CH3)-O-2'을 갖고, 이때 이 다리의 메틸기는 S 배위로 존재한다. "cEt"란 구속된(constrained) 에틸을 의미한다.
본원에서 이용된 바와 같이, "cEt 뉴클레오시드"란 cEt 당 모이어티를 포함하는 뉴클레오시드를 의미한다. 본원에서 이용된 바와 같이, "키랄 풍부 집단(chirally enriched population)"이란 동일한 분자식의 다수의 분자를 의미하며, 이때 특정 키랄 중심에서 특정 입체화학적 배열을 함유하는 집단 내 분자의 수 또는 백분율은 만약 이 특정 키랄 중심이 스테레오랜덤(stereorandom)이라면, 동일한 특정 키랄 중심에서 동일한 특정 입체화학적 배열을 함유할 것으로 예상되는 분자의 수 또는 백분율보다 크다. 각 분자내 다중 키랄 중심을 갖는 분자들의 키랄 풍부 집단은 하나 또는 그 이상의 스테레오랜덤 키랄 중심을 함유할 수 있다. 특정 구체예들에서, 상기 분자들은 변형된 올리고뉴클레오티드이다. 특정 구체예들에서, 상기 분자들은 변형된 올리고뉴클레오티드를 포함하는 화합물들이다.
본원에서 이용된 바와 같이, 뉴클레오시드간(internucleoside) 링키지 관련하여 "키랄적으로 제어된(chirally controlled)"이란 특정 입체화학적 배위에 대해 이 링키지에서 키랄성이 풍부함을 의미한다.
본원에서 이용된 바와 같이, "데옥시 영역"이란 5-12개의 연접한 뉴클레오티드의 영역을 의미하고, 이때 이 뉴클레오시드의 적어도 70%는 2'-β-D-데옥시뉴클레오시드이다. 특정 구체예들에서, 각 뉴클레오시드는 2'-β-D-데옥시뉴클레오시드, 이환 뉴클레오시드, 및 2'-치환된 뉴클레오시드로부터 선택된다. 특정 구체예들에서, 데옥시 영역은 RNase H 활성을 지원한다. 특정 구체예들에서, 데옥시 영역은 갭 또는 갭머(gapmer)의 내부 영역이다.
본원에서 이용된 바와 같이, "갭머(gapmer)"란 하나 또는 그 이상의 뉴클레오시드를 갖는 외부 영역 사이에 위치된 RNase H 분할을 지원하는 다수의 뉴클리오시트를 갖는 내부 영역을 포함하는 변형된 올리고뉴클레오티드를 의미하며, 이때 상기 내부 영역을 포함하는 뉴클레오시드는 상기 외부 영역을 포함하는 뉴클레오시드 또는 뉴클레오시드들과는 화학적으로 구별된다. 상기 내부 영역을 "갭(gap)"이라고 하고, 상기 외부 영역을 "윙(wings)"이라고 한다. 상기 내부 영역은 데옥시 영역이다. 상기 내부 영역 또는 갭의 위치는 이 내부 영역의 뉴클레오시드의 순서를 지칭하며, 이 내부 영역의 5'-단부로부터 시작하여 카운트된다. 달리 명시되지 않는 한, "갭머(gapmer)"란 당 모티프(motif)를 지칭한다. 특정 구체예들에서, 상기 갭의 각 뉴클레오시드는 2'-β-D-데옥시뉴클레오시드이다. 특정 구체예들에서, 상기 갭은 이 갭의 위치 1, 2, 3, 4, 또는 5에서 하나의 2'-치환된 뉴클레오시드를 포하하고, 상기 갭의 뉴클레오시드의 나머지들은 2'-β-D-데옥시뉴클레오시드이다. 본원에서 이용된 바와 같이, 용어 "MOE 갭머"란 갭머가 2'-β-D-데옥시뉴클레오시드를 포함하는 갭, 그리고 2'-MOE 뉴클레오시드를 포함하는 윙을 갖는다는 것을 의미한다. 본원에서 이용된 바와 같이, 용어 "혼합형 윙 갭머"란 갭머가 적어도 두 개의 상이한 당 변형을 포함하는 변형된 뉴클레오시드를 포함하는 윙을 갖는다는 것을 나타낸다. 달리 명시되지 않는 한, 갭머는 하나 또는 그 이상의 변형된 뉴클레오시드간 링키지 및/또는 변형된 핵염기를 포함할 수 있으며, 이러한 변형은 당 변형의 갭머 패턴을 반드시 따르지 않는다.
본원에서 이용된 바와 같이, "핫스팟(hotspot) 영역"은 표적 핵산의 양 또는 활성의 올리고머 화합물-매개된 감소에 순응할 수 있는 표적 핵산 상에 있는 핵염기 범위다.
본원에서 이용된 바와 같이, "혼성화(hybridization) 상보성 올리고뉴클레오티드 및/또는 핵산의 쌍형성 또는 어닐링을 의미한다. 특정 기전에 국한되지 않지만, 혼성화의 가장 흔한 기전은 수소 결합이며, 이는 상보성 핵염기 간에 Watson-Crick, Hoogsteen 또는 역전된 Hoogsteen 수소 결합일 수도 있다.
본원에서 이용된 바와 같이, "뉴클레오시드간 링키지"란 올리고뉴클레오티드에서 연접한 뉴클레오시드 간에 공유 링키지를 의미한다. 본원에서 이용된 바와 같이, "변형된 뉴클레오시드간 링키지"란 포스포디에스테르 뉴클레오시드간 링키지 이외의 임의의 뉴클레오시드간 링키지를 의미한다. "포스포로티오에이트 뉴클레오시드간 링키지"란 포스포디에스테르 뉴클레오시드간 링키지의 비-가교 산호 원자중 하나가 황 원자로 대체된, 변형된 뉴클레오시드간 링키지이다.
본원에서 이용된 바와 같이, "링커-뉴클레오시드"란 올리고뉴클레오티드가 콘쥬게이트 모이어티에 직접적으로 또는 간접적으로 연계된 뉴클레오시드를 의미한다. 링커-뉴클레오시드는 올리고머 화합물의 콘쥬게이트 링커 내에 위치한다. 링커-뉴클레오시드는 이들이 비록 올리고뉴클레오티드에 연접해 있다하더라도, 해당 올리고머 화합물의 올리고뉴클레오티드 일부분의 부분으로 간주되지 않는다.
본원에서 이용된 바와 같이, "비-이환 변형된 당 모이어티"란 제 2 고리를 형성하기 위해 해당 당에서 두 개 원자 사이에 다리를 형성하지 않는 변형, 이를 테면, 치환체를 포함하는 변형된 당 모이어티를 의미한다.
본원에서 이용된 바와 같이, "미스매치" 또는 "비-상보성"이란 제 1 올리고뉴클레이티드와 제 2 올리고뉴클레오티드를 정렬시켰을 때, 해당 제 1 올리고뉴클레오티드의 핵염기가 제 2 올리고뉴클레오티드 또는 표적 핵산의 대응하는 핵염기와 상보성이 아니라는 것을 의미한다.
본원에서 이용된 바와 같이, "모티프"란 올리고뉴클레오티드에서 변형안된 및/또는 변형된 당 모이어티, 핵염기, 및/또는 뉴클레오시드간 링키지의 패턴을 의미하다.
본원에서 이용된 바와 같이, "핵염기"란 변형안된 핵염기 또는 변형된 핵염기를 의미한다. 본원에서 이용된 바와 같이, "변형안된 핵염기"는 아데닌 (A), 티민 (T), 시토신 (C), 우라실 (U), 또는 구아닌 (G)이다. 본원에서 이용된 바와 같이, "변형된 핵염기"란 적어도 하나의 변형안된 핵염기와 쌍을 이룰 수 있는 변형안된 A, T, C, U, 또는 G 이외의 원자 기다. "5-메틸 시토신"은 변형된 핵염기이다. 범용(universal) 염기는 변형되지 않은 5개의 핵염기 중 어느 하나와 쌍을 이룰 수 있는 변형된 핵염기이다. 본원에서 이용된 바와 같이, "핵염기 서열"이란 임의의 당 또는 뉴클레오시드간 링키지 변형과 무관하게, 표적 핵산 또는 올리고뉴클레오티드의 인접 핵염기들의 순서를 말한다.
본원에서 이용된 바와 같이, "뉴클레오시드"란 핵염기와 당 모이어티를 포함하는 화합물 또는 화합물의 단편을 의미한다. 상기 핵염기와 당 모이어티는 각각, 독립적으로, 변형안 된 것이거나 또는 변형된 것이다. 본원에서 이용된 바와 같이, "변형된 뉴클레오시드"란 변형된 핵염기 및/또는 변형된 당 모이어티를 포함하는 뉴클레오시드를 의미한다. 변형된 뉴클레오시드에는 핵염기가 결여된 무염기(abasic) 뉴클레오시드가 내포된다. "연계된 뉴클레오시드(linked nucleosides)"란 연속 서열에서 연결된 뉴클레오시드들이다 (즉, 연계된 것들 사이에 추가적인 뉴클레오시드가 존재하지 않는다).
본원에서 이용된 바와 같이, "올리고머 화합물(oligomeric compound)"란 올리고뉴클레오티드와 임의선택적으로 하나 또는 그 이상의 추가적 속성, 이를 테면, 콘쥬게이트 기 또는 말단 기를 의미한다. 올리고머 화합물은 제 1 올리고머 화합물에 상보성인 제 2 올리고머 화합물과 쌍을 이루거나, 또는 쌍을 이루지 않을 수 있다. "단일-가닥으로 된(singled-stranded) 올리고머 화합물"은 쌍을 이루지 않은 올리고머 화합물이다. 용어 "올리고머 듀플렉스(duplex)"란 상보성 핵염기 서열을 갖는 두 개 올리고머 화합물에 의해 형성된 듀플렉스를 말한다. 올리고머 듀플렉스의 각 올리고머 화합물을 "듀플렉스화된 올리고머 화합물"이라고 지칭할 수 있다.
본원에서 이용된 바와 같이, "올리고뉴클레오티드"란 클레오시드간 링키지를 경유하여 연결된 연계된 뉴클레오시드의 가닥을 의미하며, 이때 각 뉴클레오시드와 뉴클레오시드간 링키지는 변형되거나 또는 변형안된 것일 수 있다. 달리 명시되지 않는 한, 올리고뉴클레오티드는 8-50개의 연계된 뉴클레오시드로 구성된다. 본원에서 이용된 바와 같이, "변형된 올리고뉴클레오티드"란 적어도 하나의 뉴클레오시드 또는 뉴클레오시드간 링키지가 변형된, 올리고뉴클레오티드를 의미한다. 본원에서 이용된 바와 같이, "변형안된 올리고뉴클레오티드"란 임의의 뉴클레오시드 변형 또는 뉴클레오시드간 변형을 포함하지 않는 올리고뉴클레오티드를 의미한다.
본원에서 이용된 바와 같이, "약제학적으로 수용가능한 담체 또는 희석제"란 대상체에 투여할 때, 사용에 적합한 임의의 물질을 의미한다. 이러한 담체는 대상체가 경구 섭취할 수 있도록, 예를 들면, 정제, 알약, 당의정, 캡슐, 액체, 겔, 시럽, 슬러리, 현탁액, 및 로젠지로 약제학적 조성물을 제형화될 수 있도록 한다. 특정 구체예들에서, 약제학적으로 수용가능한 담체 또는 희석제는 멸균수, 멸균 염수, 멸균 완충액 또는 멸균 인공 뇌척수액이다.
본원에서 이용된 바와 같이, "약제학적으로 수용가능한 염"이란 화합물의 생리학적으로 그리고 약제학적으로 수용가능한 염을 의미한다. 약제학적으로 수용가능한 염은 부모 화합물의 원하는 생물학적 활성을 유지하고, 이에 원하지 않는 독성 효과를 부여하지 않는다.
본원에서 이용된 바와 같이, "약제학적 조성물"이란 대상체에게 투여하기에 적합한 물질의 혼합물을 의미한다. 예를 들면, 약제학적 조성물은은 올리고머 화합물과 멸균 수성 용액을 포함한다. 특정 구체예들에서, 약제학적 조성물은 특정 세포 계통에서 자유 취입 검정(free uptake assay)에서 활성을 보인다.
본원에서 이용된 바와 같이, "프로드럭(prodrug)"이란 대상체의 신체 외부에서 형성된 치료요법 작용제로써 이는 대상체 또는 이들의 세포 내에서 상이한 형태로 전환되는 작용제를 말한다. 일반적으로, 대상체 내에서 프로드럭의 전환은 세포 또는 조직에 존재하는 효소(가령, 내인성 또는 바이러스성 효소) 또는 화학물질의 작용 및/또는 생리학적 조건에 의해 촉진된다.
본원에서 이용된 바와 같이, "양 또는 활성 감소"란 미처리 또는 대조군 샘플에서 전사 발현 또는 활성에 비교하여, 전사 발현 또는 활성의 감소 또는 차단을 지칭하고, 이는 반드시 전사 발현 또는 활성의 완전한 제거를 의미하지는 않는다.
본원에서 이용된 바와 같이, "RNA"는 RNA 전사체를 의미하며, 달리 명시되지 않는 한, 전-mRNA 및 성숙한 mRNA가 내포된다.
본원에서 이용된 바와 같이, "RNAi 화합물"이란 표적 핵산 및/또는 표적 핵산에 의해 인코드된 단백질을 조정하기 위해, RISC 또는 Ago2를 통하여 적어도 부분적으로 작용하는 안티센스 화합물을 의미한다. RNAi 화합물들에는 이중-가닥으로 된 siRNA, 단일-가닥으로 된 RNA (ssRNA), 그리고 microRNA 모방체(mimics)를 비롯한 microRNA가 내포되나, 이에 국한되지 않는다. 특정 구체예들에서, RNAi 화합물은 표적 핵산의 양, 활성 및/또는 스플라이싱(splicing)을 조정한다. 용어 RNAi 화합물에는 RNase H를 통하여 작용하는 안티센스 화합물들은 배제된다.
본원에서 이용된 바와 같이, 올리고뉴클레오티드 관련하여 "자가-상보성"이란 올리고뉴클레오티드가 자체에 적어도 부분적으로 혼성화되는 올리고뉴클레오티드를 의미한다.
본원에서 이용된 바와 같이, "표준 시험관내(in vitro) 검정" 또는 "표준 세포 검정(assay)"이란 실시예 1에 기재된 검정 및 그의 합리적인 변형을 의미한다.
본원에서 이용된 바와 같이, "표준 생체내(in vivo) 검정"이란 실시예 6에 기재된 검정 및 그의 합리적인 변형을 의미한다.
본원에서 이용된 바와 같이, 동일한 분자식의 분자 집단 내용에서 "스테레오랜덤 키랄 중심(stereorandom chiral center)"이란 랜덤 입체화학적 배위를 갖는 키랄 중심을 의미한다. 예를 들면, 스테레오랜덤 키랄 중심을 포함하는 분자 집단에서, (S) 배위의 스테레오랜덤 키랄 중심을 갖는 분자들의 수는 (R) 배위의 스테레오랜덤 키랄 중심을 갖는 부자의 수와 동일할 수는 있지만, 그러나 반드시 그럴 필요는 없다. 키랄 중심의 입체화학적 배위은 입체화학적 배위를 제어하도록 설계되지 않은 합성 방법의 결과인 경우, 랜덤한 것으로 간주된다. 특정 구체예들에서, 스테레오랜덤 키랄 중심은 스테레오랜덤 포스포로티오에이트 뉴클레오시드간 링키지이다.
본원에서 이용된 바와 같이, "대상체"란 인간 또는 인간-아닌 동물을 의미한다.
본원에서 이용된 바와 같이, "당 모이어티"란 변형안된 당 모이어티 또는 변형된 당 모이어티를 의미한다. 본원에서 이용된 바와 같이, "변형안된 당 모이어티"란 RNA에서 발견되는 2'-OH(H) β-D-리보실 모이어티 ("변형안된 RNA 당 모이어티"), 또는 DNA에서 발견되는 2'-H(H) β-D-데옥시리보실 모이어티 ("변형안된 DNA 당 모이어티")를 의미한다. 변형안된 당 모이어티는 위치 1', 3', 및 4'에 각각 하나의 수소를, 위치 3'에 산소를, 그리고 위치 5'에 두 개 수소를 갖는다. 본원에서 이용된 바와 같이, "변형된 당 모이어티" 또는 "변형된 당"이란 변형된 푸라노실 당 모이어티 또는 당 대체물(surrogate)를 의미한다.
본원에서 이용된 바와 같이, "당 대체물"이란 핵염기를 또다른 기, 이를 테면, 올리고뉴클레오티드에서 뉴클레오시드간 링키지, 콘쥬게이트 기, 또는 말단 기에 연계시킬 수 있는 (푸라노실 모이어티 이외의) 기들을 갖는 변형된 당 모이어티를 의미한다. 당 대체물을 포함하는 변형된 뉴클레오시드는 올리고뉴클레오티드 안에 하나 또는 그 이상의 위치로 통합될 수 있고, 이러한 올리고뉴클레오티드는 상보성 올리고머 화합물들 또는 표적 핵산에 혼성화될 수 있다.
본원에서 이용된 바와 같이, "증상(symptom) 또는 특징(hallmark)"이란 질환 또는 장애의 존재 또는 그 정도를 나타내는 임의의 신체적 특징 또는 검사 결과를 의미한다. 특정 구체예들에서, 증상은 대상체 또는 전술한 대상체를 검사하거나 또는 테스트하는 의료 전문가에게 자명하다. 특정 구체예들에서, 특징(hallmark)은 사후 검사를 비롯한, 그러나 이에 국한되지 않는 침습적 진단 검사에서 자명하다. 특정 구체예들에서, 특징은 뇌 MRI 스캔에서 자명하다.
본원에서 이용된 바와 같이, "표적 핵산" 및 "표적 RNA"란 안티센스 화합물이 영향을 주도록 기획된 핵산을 의미한다.
본원에서 이용된 바와 같이, "표적 영역(target region)"이란 올리고머 화합물이 혼성화되도록 기획된 표적 핵산의 일부분을 의미한다.
본원에서 이용된 바와 같이, "말단 기(terminal group)"란 올리고뉴클레오티드의 말단에 공유적으로 연계된 화학기 또는 원자들의 기를 의미한다.
본원에서 이용된 바와 같이, "치료요법적으로 효과량(therapeutically effective amount)"이란 대상체에게 치료요법적 이점을 제공하는 약제학적 제제의 양을 의미한다. 예를 들면, 치료요법적 효과량으로 질환의 증상 또는 특징이 개선된다.
특정 구체예들
본 명세서는 다음의 번호가 부여된 구체예들을 제공하나, 이에 국한되지 않는다:
구체예 1. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 90% 상보성이며, 이때 상기 변형된 올리고뉴클레오티드는 변형된 당 모이어티와 변형된 뉴클레오시드간 링키지로부터 선택된 적어도 하나의 변형을 포함한다.
구체예 2. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하고, 그리고 서열 식별 번호: 22-3624 또는 3655중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 17개, 18개, 19개, 또는 20개 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
구체예 3. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하고, 그리고 서열 식별 번호: 3625-3654 또는 3656-3669중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 또는 17개 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
구체예 4. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하고, 다음 서열에 대해 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는 올리고머 화합물:
서열 식별 번호: 1의 핵염기 5472-5552의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5906-6005의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7868-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8514의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446679-446706의 동일 길이 부분;
구체예 5. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하고, 다음에서 선택된 서열에서 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는 올리고머 화합물:
서열 식별 번호: 196, 274, 352, 430, 508, 2578, 2655, 2732, 2809, 2886, 2963, 3121, 3122, 3190, 3191, 3192, 3262, 3330, 3331, 3332, 3401, 3402, 3575, 3577, 3620, 3624, 3638-3640, 3653-3655, 3662, 3665, 3669;
서열 식별 번호: 42, 120, 198, 276, 509, 587, 2502, 2579, 2656, 2733, 2810, 2887, 2964, 3585, 3588-3590, 3615, 3618, 3622, 3657, 3660, 3661, 3663, 3664, 3666-3668;
서열 식별 번호: 48, 126, 2044, 2121;
서열 식별 번호: 128, 206, 284, 1045, 1122, 1199, 및 1276; 또는
서열 식별 번호: 2475, 2552, 2629, 2706, 2783, 3627-3630, 3644.
구체예 6. 구체예 1-5중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 이러한 변형된 올리고뉴클레오티드의 전체 핵염기 서열에 걸쳐 측정될 때, 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6 핵염기 서열에 대해 적어도 80%, 85%, 90%, 95%, 또는 100% 상보성인 핵염기 서열을 갖는다.
구체예 7. 구체예 1-6중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 8. 구체예 7의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 9. 구체예 8의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 이환 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 10. 구체예 9의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 2'-4' 다리를 갖는 이환 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함하고, 이때 상기 2'-4' 다리는 -O-CH2-; 및 -O-CH(CH3)-에서 선택된다.
구체예 11. 구체예 7-10중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 비-이환의, 변형된 당 모이어티를 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 12. 구체예 11의 올리고머 화합물, 이때 상기 비-이환 변형된 당 모이어티는 2'-MOE 당 모이어티 또는 2'-OMe 변형된 당 모이어티이다.
구체예 13. 구체예 7-8중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 당 대체물을 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 14. 구체예 13의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 모르폴리노 및 PNA로부터 선택된 당 대체물을 포함하는 적어도 하나의 변형된 뉴클레오시드를 포함한다.
구체예 15. 구체예 1-8 또는 11-14중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 이환 당 모이어티를 포함하지 않는다.
구체예 16. 구체예 1-15중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 갭머이다.
구체예 17. 구체예 1-16중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 포함하는 당 모티프를 갖는다:
1-6개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
6-10개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
1-6개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 변형된 당 모이어티를 포함하고, 상기 중심 영역 뉴클레오시드 각각은 2'-데옥시푸라노실 당 모이어티를 포함한다.
구체예 18. 구체예 17의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 포함하는 당 모티프를 갖는다:
6개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
10개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
4개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 중심 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 19. 구체예 17의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 포함하는 당 모티프를 갖는다:
5개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
10개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
5개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 중심 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 20. 구체예 17의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖는다:
5개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
8개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
4개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드를 포함하고, 상기 중심 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 21. 구체예 17의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖는다:
5개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
8개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
4개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드 각각은 2'-MOE 당 모이어티를 포함하고, 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되며, 상기 중심 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드를 포함한다.
구체예 22. 구체예 1-16중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 포함하는 당 모티프를 갖는다:
1-6개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
6-10개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
1-6개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역, 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 변형된 당 모이어티를 포함하고,
그리고 상기 중심 영역은 다음 식을 갖는다:
(Nd)(Nx)(Nd)n
이때 Nx는 2'-OMe 뉴클레오시드이고, 각 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 6 ~ 8이다.
구체예 23. 구체예 1-16중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 포함하는 당 모티프를 갖고:
5개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역;
6-10개의 계된 중심 영역 뉴클레오시드로 구성된 중심 영역; 그리고
4개의 연계된 3'-영역 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고,
그리고 상기 중심 영역은 다음 식을 갖고:
(Nd)(Nx)(Nd)n
이때 Nx는 2'-OMe 뉴클레오시드이고, 각 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 7이다.
구체예 24. 구체예 1-23중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 뉴클레오시드간 링키지를 포함한다.
구체예 25. 구체예 24의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 변형된 뉴클레오시드간 링키지이다.
구체예 26. 구체예 24 또는 25의 올리고머 화합물, 이때 상기 변형된 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 27. 구체예 24 또는 26의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 적어도 하나의 포스포디에스테르 뉴클레오시드간 링키지를 포함한다.
구체예 28. 구체예 24, 26, 또는 27중 임의의 구체예의 올리고머 화합물, 이때 각 뉴클레오시드간 링키지는 독립적으로 포스포디에스테르 뉴클레오시드간 링키지 또는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 29. 구체예 1-24 또는 26-28중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음중에서 선택된 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖고;
이때,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고 o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 30. 구체예 1-29중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 변형된 핵염기를 포함한다.
구체예 31. 구체예 30의 올리고머 화합물, 이때 상기 변형된 핵염기는 5-메틸 시토신이다.
구체예 32. 구체예 1-31중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 12-30개, 12-22개, 12-20개, 14-18개, 16-18개, 14-20개, 15-17개, 15-25개, 16-20개, 또는 17-20개의 연계된 뉴클레오시드로 구성된다.
구체예 33. 구체예 1-2, 4-19, 22 또는 24-31중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 18-22개 또는 18-20개의 연계된 뉴클레오시드로 구성된다.
구체예 34. 구체예 1-17 또는 20-32중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 17개의 연계된 뉴클레오시드로 구성된다.
구체예 35. 구체예 1-2, 4-19, 22 또는 24-31중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 20개의 연계된 뉴클레오시드로 구성된다.
구체예 36. 구체예 1-35중 임의의 구체예의 올리고머 화합물, 상기 변형된 올리고뉴클레오티드로 구성된다.
구체예 37. 구체예 1-35중 임의의 구체예의 올리고머 화합물, 콘쥬게이트 모이어티 및 콘쥬게이트 링커를 포함하는 콘쥬게이트 기를 포함한다.
구체예 38. 구체예 37의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 단일 결합으로 구성된다.
구체예 39. 구체예 37의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 절단가능하다.
구체예 40. 구체예 37의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 1-3개의 링커-뉴클레오시드를 포함한다.
구체예 41. 구체예 37-40중 임의의 구체예의 올리고머 화합물, 이때 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 5'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된다.
구체예 42. 구체예 37-40중 임의의 구체예의 올리고머 화합물, 이때 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 3'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된다.
구체예 43. 구체예 1-35 또는 37-42중 임의의 구체예의 올리고머 화합물, 말단 기를 포함한다.
구체예 44. 구체예 1-43중 임의의 구체예의 올리고머 화합물, 이때 상기 올리고머 화합물은 단일-가닥으로 된 올리고머 화합물이다.
구체예 45. 구체예 1-39 또는 41-42중 임의의 구체예의 올리고머 화합물, 이때 상기 올리고머 화합물은 링커-뉴클레오시드를 포함하지 않는다.
구체예 46. 구체예 1-43 또는 45중 임의의 구체예의 올리고머 화합물을 포함하는 올리고머 듀플렉스.
구체예 47. 구체예 1-45중 임의의 구체예의 올리고머 화합물 또는 구체예 46의 올리고머 듀플렉스를 포함하거나, 또는 이로 구성된 안티센스 화합물.
구체예 48. 구체예 1-45중 임의의 구체예의 올리고머 화합물 또는 구체예 46의 올리고머 듀플렉스, 그리고 약제학적으로 수용가능한 담체 또는 희석제를 포함하는 약제학적 조성물.
구체예 49. 구체예 48의 약제학적 조성물, 이때 상기 약제학적으로 수용가능한 희석제는 인공 뇌척수액이다.
구체예 50. 구체예 49의 약제학적 조성물, 이때 상기 약제학적 조성물은 상기 변형된 올리고뉴클레오티드 및 인공 뇌척수액으로 본질적으로 구성된다.
구체예 51. 대상체에게 구체예 48-50중 임의의 구체예의 약제학적 조성물을 투여하는 것을 포함하는 방법.
구체예 52. ATXN1과 연관된 질환을 가지고 있거나, 또는 발병 위험을 갖는 개체에게 구체예 48-50중 임의의 구체예의 약제학적 조성물의 치료요법적 효과량을 투여하고; 그리고 이로 인하여 ATXN1과 연관된 질환을 치료하는 것을 포함하는 ATXN1과 연관된 질환을 치료하는 방법.
구체예 53. 구체예 52의 방법, 이때 상기 ATXN1-연관된 질환은 제1형 척수소뇌성 운동실조이다.
구체예 54. 구체예 51-52중 임의의 구체예의 방법, 이때 상기 ATXN1-연관된 질환의 적어도 하나의 증상 또는 특징이 개선된다.
구체예 55. 구체예 54의 방법, 이때 상기 증상 또는 특징은 보행 및 사지 운동실조, 인지 장애, 말하기 또는 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및/또는 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및/또는 뇌간의 신경화학적 이상 또는 증상 발병 후 10-15년 이내에 사망이다.
구체예 56. 구체예 51-53중 임의의 구체예의 방법, 이때 상기 개체에서 ATXN1 수준이 감소된다.
구체예 57. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 58. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 59. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 60. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 61. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 62. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 63. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 64. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 65. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 66. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 67. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 68. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 69. 구체예 57-62중 임의의 구체예의 변형된 올리고뉴클레오티드, 이는 나트륨염 또는 칼륨염이다.
구체예 70. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Aeo mCeo Ges Gds Tds Ads Tds Tds Ads Gds Tds Gds Tds mCeo Teo Tes mCes Ae (서열 식별 번호: 126), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 71. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Teo Teo mCes Tds mCds Ads Ads Ads Tds mCds Ads Gds Gds Teo Geo Tes Aes mCe (서열 식별 번호: 1045), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 72. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo mCeo Teo Tes Tds Ads Tds Ads Ads mCds Tds Tds Tds Tds mCeo Teo Tes Tes mCe (서열 식별 번호: 2552), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 73. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes Teo mCeo Aeo Ges Tds Tds Tds Ads Gds Tds Tds Gds mCds Ads Geo mCeo mCes Aes Te (서열 식별 번호: 3190), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 74. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
mCes mCeo mCeo Geo Tes Ads Tds Tds mCds mCds Tds mCds Tds Tds Ads mCeo mCeo Aes Tes mCe (서열 식별 번호: 3590), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 75. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes mCes Aes Geo Tes Tds Tds Ads Gds Tds Tds Gds mCds Aeo Ges mCes mCe (서열 식별 번호: 3638), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 76. 구체예 73-78의 임의의 구체예의 화합물, 이는 콘쥬게이트 기에 공유적으로 연계된 변형된 올리고뉴클레오티드를 포함한다.
구체예 77. 구체예 57-68중 임의의 구체예의 변형된 올리고뉴클레오티드의 키릴적으로 풍부한 집단, 이때 상기 집단은 특정 입체화학적 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 78. 구체예 77의 변형된 올리고뉴클레오티드의 키릴적으로 풍부한 집단, 이때 상기 집단은 (Sp) 또는 (Rp) 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 79. 구체예 77의 키릴적으로 풍부한 집단, 이때 상기 집단은 각 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된 특정 입체화학적 배위를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 80. 구체예 77의 키릴적으로 풍부한 집단, 이때 상기 집단은 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지에서 (Rp) 배위를 갖고, 나머지 각 포스포로티오에이트 뉴클레오시드간 링키지에서 (Sp) 배위를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 81. 구체예 77의 키릴적으로 풍부한 집단, 이때 상기 집단은 5'에서 3' 방량으로, Sp, Sp, 및 Rp 배위의 적어도 3개의 연접한 포스포로티오에이트 뉴클레오시드간 링키지를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 82. 구체예 57-68중 임의의 구체예의 변형된 올리고뉴클레오티드 집단, 이때 상기 변형된 올리고뉴클레오티드의 모든 포스포로티오에이트 뉴클레오시드간 링키지들은 스테레오랜덤이다.
구체예 83. 구체예 77-82중 임의의 구체예의 변형된 올리고뉴클레오티드 집단과 약제학적으로 수용가능한 희석제 또는 담체를 포함하는 약제학적 조성물.
구체예 84. 구체예 62-75중 임의의 구체예의 약제학적 조성물, 그리고 약제학적으로 수용가능한 희석제 또는 담체.
구체예 85. 구체예 84의 약제학적 조성물, 이때 상기 약제학적으로 수용가능한 희석제는 인공 뇌척수액 또는 포스페이트-완충된 염수이다.
구체예 86. 구체예 85의 약제학적 조성물, 이때 상기 약제학적 조성물은 상기 변형된 올리고뉴클레오티드 및 인공 뇌척수액 또는 포스페이트-완충된 염수로 본질적으로 구성된다.
구체예 87. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 80% 상보성이며, 이때 상기 변형된 올리고뉴클레오티드는 변형된 당 모이어티와 변형된 뉴클레오시드간 링키지로부터 선택된 적어도 하나의 변형을 포함한다.
구체예 88. 구체예 87의 올리고머 화합물, 이때 상기 ATXN1 핵산은 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6중 임의의 하나의 핵염기 서열을 갖는다.
구체예 89. 구체예 87 또는 구체예 88의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 핵염기 내 동일 길이 부분에 대해 적어도 80% 상보성이다:
서열 식별 번호: 1의 핵염기 5472-5552의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5906-6005의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7868-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8514의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446679-446706의 동일 길이 부분;
구체예 90. 구체예 87-89중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 핵염기 내 동일 길이 부분에 대해 적어도 80% 상보성이다:
서열 식별 번호: 1의 핵염기 5489-5508의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5491-5507의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5912-5931의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7892-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8500의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446680-446699의 동일 길이 부분;
구체예 91. 구체예 87-90의 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이에 대해 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성이다.
구체예 92. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3624 또는 3655중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 17개, 18개, 19개, 또는 20개 연접한 핵염기를 포함하는 핵염기 서열을 갖는다.
구체예 93. 12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 3625-3654 또는 3656-3669중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 또는 17개 연접한 핵염기를 포함하는 핵염기 서열을 갖는다.
구체예 94. 구체예 92 또는 93중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3669중 임의의 서열의 핵염기 서열을 포함하는 핵염기 서열을 갖는다.
구체예 95. 구체예 94의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3669중 임의의 서열의 핵염기 서열로 구성된 핵염기 서열을 갖는다.
구체예 96. 구체예 92-95중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음에서 선택된 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개의 연접한 핵염기를 포함하는 핵염기 서열을 갖고:
서열 식별 번호: 196, 274, 352, 430, 508, 2578, 2655, 2732, 2809, 2886, 2963, 3121, 3122, 3190, 3191, 3192, 3262, 3330, 3331, 3332, 3401, 3402, 3575, 3577, 3620, 3624, 3638-3640, 3653-3655, 3662, 3665, 3669;
서열 식별 번호: 42, 120, 198, 276, 509, 587, 2502, 2579, 2656, 2733, 2810, 2887, 2964, 3585, 3588-3590, 3615, 3618, 3622, 3657, 3660, 3661, 3663, 3664, 3666-3668;
서열 식별 번호: 48, 126, 2044, 2121;
서열 식별 번호: 128, 206, 284, 1045, 1122, 1199, 및 1276; 또는
서열 식별 번호: 2475, 2552, 2629, 2706, 2783, 3627-3630, 3644.
구체예 97. 구체예 92-95의 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 3638의 임의의 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는다.
구체예 98. 구체예 92-95중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 126, 1045, 2552, 3190, 또는 3590의 임의의 서열의 핵염기 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는다.
구체예 99. 구체예 97 또는 98의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 17 내지 30개의 연계된 뉴클레오시드로 구성되며, 126, 1045, 2552, 3190, 3590, 또는 3638중 임의의 서열의 핵염기 서열을 갖는다
구체예 100. 구체예 99의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 126, 1045, 2552, 3190, 3590, 또는 3638중 임의의 하나의 핵염기 서열로 구성된 핵염기 서열을 갖는다.
구체예 101. 구체예 92-100중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성이며, 이때 상기 ATXN1 핵산은 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6의 핵염기 서열을 갖는다.
구체예 102. 구체예 87-101중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함한다.
구체예 103. 구체예 102의 올리고머 화합물, 이때 상기 변형된 당 모이어티는 이환 당모이어티를 포함한다.
구체예 104. 구체예 103의 올리고머 화합물, 이때 상기 이환 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-에서 선택된 2'-4' 다리를 포함한다.
구체예 105. 구체예 102-104중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 뉴클레오시드는 비-이환 변형된 당 모이어티를 포함한다.
구체예 106. 구체예 105의 올리고머 화합물, 이때 상기 비-이환 변형된 당모이어티는 2'-MOE 당 모이어티 또는 2'-OMe 변형된 당 모이어티이다.
구체예 107. 구체예 102-106중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 당 대체물을 포함한다.
구체예 108. 구체예 107의 올리고머 화합물, 이때 상기 당 대체물은 모르폴리노 및 PNA로부터 선택된다.
구체예 109. 구체예 87-102 또는 105-108중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 이환 당 모이어티를 포함하지 않는다.
구체예 110. 구체예 87-109중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 뉴클레오시드간 링키지를 포함한다.
구체예 111. 구체예 110의 올리고머 화합물, 이때 적어도 하나의 변형된 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 112. 구체예 110 또는 111의 올리고머 화합물, 이때 각 뉴클레오시드간 링키지는 변형된 뉴클레오시드간 링키지이다.
구체예 113. 구체예 112의 올리고머 화합물, 이때 각 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 114. 구체예 110-111중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이다.
구체예 115. 구체예 87-109중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 또는 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된다
구체예 116. 구체예 87-115중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드의 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개, 또는 적어도 18개의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 117. 구체예 116의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음에서 선택된 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖고;
이때,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고 o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 118. 구체예 87-117중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 변형된 핵염기를 포함한다.
구체예 119. 구체예 118의 올리고머 화합물, 이때 상기 변형된 핵염기는 5-메틸 시토신이다.
구체예 120. 구체예 1-33중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 5-12개의 연접한 2'-데옥시뉴클레오시드로 구성된 데옥시 영역을 포함한다.
구체예 121. 구체예 120의 올리고머 화합물, 이때 상기 데옥시 영역의 각 뉴클레오시드는 2'-β-D-데옥시뉴클레오시드이다.
구체예 122. 구체예 120 또는 121의 올리고머 화합물, 이때 상기 데옥시 영역은 6개, 7개, 8개, 9개, 10개, 또는 6-10개의 연계된 뉴클레오시드로 구성된다.
구체예 123. 구체예 120-122중 임의의 구체예의 올리고머 화합물, 이때 상기 데옥시 영역에 바로 인접한 각 뉴클레오시드는 변형된 당 모이어티를 포함한다.
구체예 124. 구체예 120-122중 임의의 구체예의 올리고머 화합물, 이때 상기 데옥시 영역은 5'-측면에 1-6개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역에 의해, 및 3'-측면에 1-6개의 연계된 3'-영역 뉴클레오시드로 구성된 3'외부 영역에 의해 플랭킹되며,
상기 5'-영역의 3'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함하고; 그리고
상기 3'-영역의 5'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함한다.
구체예 125. 구체예 124의 올리고머 화합물, 이때 상기 3'-영역의 각 뉴클레오시드는 변형된 당 모이어티를 포함한다.
구체예 126. 구체예 124 또는 125의 올리고머 화합물, 이때 상기 5'-영역의 각 뉴클레오시드 변형된 당 모이어티를 포함한다.
구체예 127. 구체예 120-126중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
1-6개의 연계된 뉴클레오시드로 구성된 5'-영역;
6-10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
1-6개의 연계된 뉴클레오시드로 구성된 3'-영역; 이때
상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 변형된 당 모이어티를 포함한다.
구체예 128. 구체예 127의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
6개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 129. 구체예 127의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 중심 영역; 그리고
5개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 130. 구체예 127의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 131. 구체예 127의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드 각각는 2'-MOE 뉴클레오시드이고, 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
구체예 132. 구체예 87-119중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
3-7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6-8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
3-6개의 연계된 뉴클레오시드로 구성된 3' 영역; 이때
상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 1 ~ 5이다.
구체예 133. 구체예 87-119중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 다음을 갖고:
7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3' 영역;
이때 상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 5이다.
구체예 134. 구체예 87-133중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 12-30개, 12-22개, 12-20개, 14-18개, 16-18개, 14-20개, 15-17개, 15-25개, 16-20개, 또는 17-20개의 연계된 뉴클레오시드로 구성된다.
구체예 135. 구체예 87-132중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 18-22개 또는 18-20개의 연계된 뉴클레오시드로 구성된다.
구체예 136. 구체예 87-133중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 17개의 연계된 뉴클레오시드로 구성된다.
구체예 137. 구체예 87-132중 임의의 구체예의 올리고머 화합물, 이때 상기 변형된 올리고뉴클레오티드는 20개의 연계된 뉴클레오시드로 구성된다.
구체예 138. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Aeo mCeo Ges Gds Tds Ads Tds Tds Ads Gds Tds Gds Tds mCeo Teo Tes mCes Ae (서열 식별 번호: 126), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 139. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Teo Teo mCes Tds mCds Ads Ads Ads Tds mCds Ads Gds Gds Teo Geo Tes Aes mCe (서열 식별 번호: 1045), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 140. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo mCeo Teo Tes Tds Ads Tds Ads Ads mCds Tds Tds Tds Tds mCeo Teo Tes Tes mCe (서열 식별 번호: 2552), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 141. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes Teo mCeo Aeo Ges Tds Tds Tds Ads Gds Tds Tds Gds mCds Ads Geo mCeo mCes Aes Te (서열 식별 번호: 3190), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 142. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
mCes mCeo mCeo Geo Tes Ads Tds Tds mCds mCds Tds mCds Tds Tds Ads mCeo mCeo Aes Tes mCe (서열 식별 번호: 3590), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 143. 다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes mCes Aes Geo Tes Tds Tds Ads Gds Tds Tds Gds mCds Aeo Ges mCes mCe (서열 식별 번호: 3638), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
구체예 144. 구체예 87-143중 임의의 구체예의 올리고머 화합물, 이는 상기 변형된 올리고뉴클레오티드로 구성된다
구체예 145. 구체예 87-144중 임의의 구체예의 올리고머 화합물, 이는 콘쥬게이트 모이어티 및 콘쥬게이트 링커를 포함하는 콘쥬게이트 기를 포함한다.
구체예 146. 구체예 145의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 단일 결합으로 구성된다.
구체예 147. 구체예 145의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 절단가능하다.
구체예 148. 구체예 145의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 1-3개의 링커 뉴클레오시드를 포함한다.
구체예 149. 구체예 145-148중 임의의 구체예의 올리고머 화합물, 이때 상기 콘쥬게이트 링커는 임의의 링커 뉴클레오시드를 포함하지 않는다.
구체예 150. 구체예 145-148중 임의의 구체예의 올리고머 화합물, 이때 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 5'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된다.
구체예 151. 구체예 145-148중 임의의 구체예의 올리고머 화합물, 이때 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 3'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된다.
구체예 152. 구체예 87-143 또는 146-148중 임의의 구체예의 올리고머 화합물, 이는 말단 기를 포함한다.
구체예 153. 구체예 152의 올리고머 화합물, 이때 말단 기는 무염기 당 모이어티이다.
구체예 154. 구체예 87-153중 임의의 구체예의 올리고머 화합물, 이때 상기 올리고머 화합물은 단일-가닥으로 된 올리고머 화합물이다.
구체예 155. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 156. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 157. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 158. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 159. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 160. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 161. 구체예 155-160의 임의의 구체예의 변형된 올리고뉴클레오티드, 이는 나트륨염 또는 칼륨염이다.
구체예 162. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 163. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 164. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 165. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 166. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 167. 다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
구체예 168. 구체예 87-154중 임의의 구체예의 올리고머 화합물의 키랄 풍부 집단, 또는 구체예 155-167의 변형된 올리고뉴클레오티드, 이때 상기 집단은 특정 입체화학적 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 169. 구체예 168의 키랄 풍부 집단, 이때 상기 집단은 (Sp) 또는 (Rp) 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 170. 구체예 169의 키랄 풍부 집단, 이때 상기 집단은 각 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된 특정 입체화학적 배위를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 171. 구체예 170의 키랄 풍부 집단, 이때 상기 집단은 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지에서 (Rp) 배위를 갖고, 나머지 각 포스포로티오에이트 뉴클레오시드간 링키지에서 (Sp) 배위를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 172. 구체예 171의 키랄 풍부 집단, 이때 상기 집단은 5'에서 3' 방량으로, Sp, Sp, 및 Rp 배위의 적어도 3개의 연접한 포스포로티오에이트 뉴클레오시드간 링키지를 갖는 변형된 올리고뉴클레오티드가 풍부하다.
구체예 173. 구체예 87-154중 임의의 구체예의 변형된 올리고뉴클레오티드, 또는 구체예 155-167의 변형된 올리고뉴클레오티드 집단을 포함하는 올리고머 화합물들의 집단, 이때 상기 변형된 올리고뉴클레오티드의 모든 포스포로티오에이트 뉴클레오시드간 링키지들은 스테레오랜덤이다.
구체예 174. 제 1 올리고머 화합물, 그리고 제 2 변형된 올리고뉴클레오티드를 포함하는 제 2 올리고머 화합물을 포함하는 올리고머 듀플렉스, 이때 상기 제 1 올리고머 화합물은 구체예 87-154중 임의의 구체예의 올리고머 화합물이다.
구체예 175. 구체예 174의 올리고머 듀플렉스, 이때 상기 제 2 올리고머 화합물은 12 ~ 30개의 연계된 뉴클레오시드로 구성된 제 2 변형된 올리고뉴클레오티드를 포함하고, 이때 상기 제 2 변형된 올리고뉴클레오티드의 핵염기 서열은 상기 제 1 변형된 올리고뉴클레오티드의 동일 길이 부분에 대해 적어도 90% 상보성인 적어도 8개의 핵염기 상보성 영역을 포함한다.
구체예 176. 구체예 174 또는 175의 올리고머 듀플렉스, 이때 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 5'-안정화된 포스페이트 기를 포함한다.
구체예 177. 구체예 176의 올리고머 듀플렉스, 이때 상기 안정화된 포스페이트 기는 시클로프로필 포스포네이트 또는 비닐 포스포네이트를 포함한다.
구체예 178. 구체예 174-177중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 글리콜 핵산 (GNA) 당 대체물을 포함한다.
구체예 179. 구체예 174-178중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 2'-NMA 당 모이어티를 포함한다.
구체예 180. 구체예 174-179중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함한다.
구체예 181. 구체예 180의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 변형된 당 모이어티는 이환 당 모이어티를 포함한다.
구체예 182. 구체예 181의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 이환 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-에서 선택된 2'-4' 다리를 포함한다.
구체예 183. 구체예 182의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 변형된 당 모이어티는 비-이환 변형된 당 모이어티를 포함한다.
구체예 184. 구체예 183의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 비-이환 변형된 당 모이어티는 2'-MOE 당 모이어티, 2'-F 당 모이어티, 또는 2'-OMe 당 모이어티이다.
구체예 185. 구체예 174-184중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 당 대체물을 포함한다.
구체예 186. 구체예 174-185중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 변형된 뉴클레오시드간 링키지이다.
구체예 187. 구체예 186의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 변형된 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다.
구체예 188. 구체예 174-187중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이다.
구체예 189. 구체예 174-188중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 또는 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된다.
구체예 190. 구체예 174-189중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지, 포스포로티오에이트 뉴클레오시드간 링키지, 또는 메실 포스포라미데이트 뉴클레오시드간 링키지에서 독립적으로 선택된다.
구체예 191. 구체예 174-190중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 핵염기를 포함한다.
구체예 192. 구체예 191의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드의 변형된 핵염기는 5-메틸시토신이다.
구체예 193. 구체예 174-192중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드는 콘쥬게이트 기를 포함한다.
구체예 194. 구체예 193의 올리고머 듀플렉스, 이때 상기 콘쥬게이트 기는 콘쥬게이트 링커 및 콘쥬게이트 모이어티를 포함한다.
구체예 195. 구체예 193 또는 194의 올리고머 듀플렉스, 이때 상기 콘쥬게이트 기는 상기 제 2 변형된 올리고뉴클레오티드의 5'-단부에서 상기 제 2 변형된 올리고뉴클레오티드에 부착된다.
구체예 196. 구체예 193 또는 194의 올리고머 듀플렉스, 이때 상기 콘쥬게이트 기는 상기 제 2 변형된 올리고뉴클레오티드의 3'-단부에서 이 변형된 올리고뉴클레오티드에 부착된다.
구체예 197. 구체예 193-196중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드는 말단 기를 포함한다.
구체예 198. 구체예 197의 올리고머 듀플렉스, 이때 말단 기는 무염기 당 모이어티이다.
구체예 199. 구체예 174-198중 임의의 구체예의 올리고머 듀플렉스, 이때 상기 제 2 변형된 올리고뉴클레오티드는 10 ~ 25, 10 ~ 30, 10 ~ 50, 12 ~ 20, 12 ~ 25, 12 ~ 30, 12 ~ 50, 13 ~ 20, 13 ~ 25, 13 ~ 30, 13 ~ 50, 14 ~ 20, 14 ~ 25, 14 ~ 30, 14 ~ 50, 15 ~ 20, 15 ~ 25, 15 ~ 30, 15 ~ 50, 16 ~ 18,16 ~ 20, 16 ~ 25, 16 ~ 30, 16 ~ 50, 17 ~ 20, 17 ~ 25, 17 ~ 30, 17 ~ 50, 18 ~ 20, 18 ~ 25, 18 ~ 30, 18 ~ 50, 19 ~ 20, 19 ~ 25, 19 ~ 30, 19 ~ 50, 20 ~ 25, 20 ~ 30, 20 ~ 50, 21 ~ 25, 21 ~ 30, 21 ~ 50, 22 ~ 25, 22 ~ 30, 22 ~ 50, 23 ~ 25, 23 ~ 30, 또는 23 ~ 50개의 연계된 뉴클레오시드로 구성된다.
구체예 200. 안티센스 화합물을 포함하는 안티센스 작용제, 이때 상기 안티센스 화합물은 구체예 87-154중 임의의 구체예의 올리고머 화합물, 또는 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드이다.
구체예 201. 구체예 200의 안티센스 작용제, 이때 상기 안티센스 작용제는 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스다.
구체예 202. 구체예 200 또는 201의 안티센스 작용제, 이때 상기 안티센스 작용제는 RNase H의 활성화를 통하여 ATXN1 핵산 양을 감소시킬 수 있는 RNase H 작용제이다.
구체예 203. 구체예 200-202중 임의의 구체예의 안티센스 작용제, 이때 상기 콘쥬게이트 기는 세포-표적화 모이어티를 포함한다.
구체예 204. 구체예 87-154중 임의의 구체예의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 또는 구체예 200-203중 임의의 구체예의 안티센스 작용제, 그리고 약제학적으로 수용가능한 담체 또는 희석제를 포함하는 약제학적 조성물.
구체예 205. 구체예 204의 약제학적 조성물, 이때 상기 약제학적으로 수용가능한 희석제는 물, 포스페이트-완충된 염수, 또는 인공 뇌척수액이다.
구체예 206. 구체예 205의 약제학적 조성물, 이때 상기 약제학적 조성물은 변형된 올리고뉴클레오티드 및 인공 뇌척수액으로 본질적으로 구성된다.
구체예 207. 구체예 87-154의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 구체예 200-203중 임의의 구체예의 안티센스 작용제, 또는 구체예 204-206중 임의의 구체예의 약제학적 조성물을 대상체에게 투여하는 것을 포함하는 방법.
구체예 208. 구체예 87-154중 임의의 구체예의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 구체예 200-203중 임의의 구체예의 안티센스 작용제, 또는 구체예 204-206중 임의의 구체예의 약제학적 조성물의 치료요법적 효과량을 ATXN1과 연관된 질환을 가진 대상체에게 투여하고; 이로써 ATXN1과 연관된 질환을 치료하는 것을 포함하는, ATXN1과 연관된 질환을 치료하는 방법.
구체예 209. 구체예 208의 방법, 이때 상기 ATXN1-연관된 질환은 제1형 척수소뇌성 운동실조이다.
구체예 210. 구체예 208-209중 임의의 구체예의 방법, 이때 상기 ATXN1-연관된 질환의 적어도 하나의 증상 또는 특징은 개선된다.
구체예 211. 구체예 210의 방법, 이때 상기 증상 또는 특징은 보행 및 사지 운동실조, 인지 장애, 말하기 또는 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및/또는 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및/또는 뇌간의 신경화학적 이상 또는 증상 발병 후 10-15년 이내에 사망이다.
구체예 212. 구체예 208-211중 임의의 구체예의 방법, 이때 상기 대상체에서 ATXN1 수준이 감소된다.
구체예 213. 구체예 87-154의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 구체예 200-203중 임의의 구체예의 안티센스 작용제, 또는 구체예 204-206중 임의의 구체예의 약제학적 조성물을 세포와 접촉시키는 것을 포함하는, 해당 세포에서 ATXN1의 발현을 감소시키는 방법.
구체예 214. 구체예 213의 방법, 이때 상기 세포는 CNS 세포이다.
구체예 215. 올리고머 ATXN1과 연관된 질환 치료를 위한 구체예 87-154중 임의의 구체예의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 구체예 200-203중 임의의 구체예의 안티센스 작용제, 또는 구체예 204-206중 임의의 구체예의 약제학적 조성물의 용도.
구체예 216. ATXN1과 연관된 질환 치료용 약물 제조에서 구체예 87-154중 임의의 구체예의 올리고머 화합물, 구체예 155-167중 임의의 구체예의 변형된 올리고뉴클레오티드, 구체예 168-173중 임의의 구체예의 집단, 구체예 174-199중 임의의 구체예의 올리고머 듀플렉스, 구체예 200-203중 임의의 구체예의 안티센스 작용제, 또는 구체예 204-206중 임의의 구체예의 약제학적 조성물의 용도.
구체예 217. 구체예 215 또는 216의 용도, 이때 상기 ATXN1과 연관된 질환은 제1형 척수소뇌성 운동실조이다.
I.
특정 올리고뉴클레오티드
특정 구체예들에서, 연계된 뉴클레오시드로 구성된, 올리고뉴클레오티드를 포함하는 올리고머 화합물들이 본원에 제공된다. 올리고뉴클레오티드는 변형안된 올리고뉴클레오티드 (RNA 또는 DNA)이거나, 또는 변형된 올리고뉴클레오티드일 수 있다. 변형된 올리고뉴클레오티드는 변형안된 RNA 또는 DNA에 비해 적어도 하나의 변형을 포함한다. 즉, 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 뉴클레오시드 (변형된 당 모이어티 및/또는 변형된 핵염기를 포함하는) 및/또는 적어도 하나의 변형된 뉴클레오시드간 링키지를 포함한다.
A.
특정 변형된 뉴클레오시드
변형된 뉴클레오시드는 변형된 당 모이어티 또는 변형된 핵염기를 포함하거나, 또는 변형된 당 모이어티 및 변형된 핵염기를 모두 포함한다.
1.
특정 당 모이어티
특정 구체예들에서, 변형된 당 모이어티는 비-이환 변형된 당 모이어티들이다. 특정 구체예들에서, 변형된 당 모이어티들은 이환 또는 삼환 당 모이어티들이다. 특정 구체예들에서, 변형된 당 모이어티는 당 대체물이다. 이러한 당 대체물은 변형된 당 모이어티의 다른 유형들에 대응하는 하나 또는 그 이상의 치환을 포함할 수 있다.
특정 구체예들에서, 변형된 당 모이어티는 하나 또는 그 이상의 치환기를 갖는 푸라노실 고리를 포함하는 비-이환 변형된 당 모이어티들이며, 이들중 것도 이환 구조를 형성하기 위해 상기 푸라노실 고리의 두개 원자를 연결시키지 않는다. 이러한 비-다리연결 치환은 푸라노실의 위치 2', 4', 및/또는 5'에서 치환을 비롯한, 그러나 이에 국한되지 않는 푸라노실의 임의의 위치에 있을 수 있다. 특정 구체예들에서, 비-이환 변형된 당 모이어티들의 하나 또는 그 이상의 비-다리연결 치환은 분기형(branched)이다. 비-이환 변형된 당 모이어티에 적합한 2'-치환기의 예로는 다음이 내포되나, 이에 국한되지 않는다: 2'-F, 2'-OCH3 ("OMe" 또는 "O-메틸"), 그리고 2'-O(CH2)2OCH3 ("MOE" 또는 "O-메톡시에틸"). 특정 구체예들에서, 2'-치환기는 다음중에서 선택된다: 할로(halo), 알릴, 아미노, 아지도, SH, CN, OCN, CF3, OCF3, O-C1-C10 알콕시, O-C1-C10 치환된 알콕시, O-C1-C10 알킬, O-C1-C10 치환된 알킬, S-알킬, N(Rm)-알킬, O-알케닐, S-알케닐, N(Rm)-알케닐, O-알키닐, S-알키닐, N(Rm)-알키닐, O-알킬에닐-O-알킬, 알키닐, 알카릴, 아랄킬, O-알카릴, O-아랄킬, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn) 또는 OCH2C(=O)-N(Rm)(Rn), 여기에서 Rm 및 Rn 각각은 독립적으로, H, 아미노 보호기, 또는 치환된 또는 치환안된 C1-C10 알킬, 그리고 Cook et al., U.S. 6,531,584; Cook et al., U.S. 5,859,221; 및 Cook et al., U.S. 6,005,087에서 기술된 2'-치환기들이다. 이들 2'-치환기의 특정 구체예들은 다음중 히드록실, 아미노, 알콕시, 카르복시, 벤질, 페닐, 니트로 (NO2), 티올, 티오알콕시, 티오알킬, 할로겐, 알킬, 아릴, 알케닐 및 알키닐중에서 독립적으로 선택된 하나 또는 그 이상의 치환기일 수 있다. 비-이환 변형된 당 모이어티에 적합한 4'-치환기의 예로는 알콕시 (가령, 메톡시), 알킬, 그리고 Manoharan et al., WO 2015/106128에서 기술된 것들이 내포되나, 이에 국한되지 않는다. 비-이환 변형된 당 모이어티에 적합한 5'-치환기의 예로는 다음이 내포되나, 이에 국한되지 않는다: 5-메틸 (R 또는 S), 5'-비닐, 그리고 5'-메톡시. 특정 구체예들에서, 비-이환 변형된 당 모이어티는 하나 이상의 비-다리연결 당 치환체, 예를 들면, 2'-F-5'-메틸 당 모이어티와 Migawa et al., WO 2008/101157 및 Rajeev et al., US2013/0203836에서 기술된 변형된 당 모이어티 및 변형된 뉴클레오시드를 포함한다.
특정 구체예들에서, 2'-치환된 비-이환 변형된 뉴클레오시드는 다음에서 선택된 비-다리연결 2'-치환기를 포함하는 당 모이어티를 포함한다. F, NH2, N3, OCF3, OCH3, O(CH2)3NH2, CH2CH=CH2, OCH2CH=CH2, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(Rm)(Rn), O(CH2)2O(CH2)2N(CH3)2, 그리고 N-치환된 아세타미드 (OCH2C(=O)-N(Rm)(Rn)), 여기에서 Rm 및 Rn 각각은 독립적으로 H, 아미노 보호기, 또는 치환된 또는 치환안된 C1-C10 알킬이다.
특정 구체예들에서, 2'-치환된 뉴클레오시드 비-이환 변형된 뉴클레오시드는 다음에서 선택된 비-다리연결 2'-치환기를 당 모이어티를 포함한다: F, OCF3, OCH3, OCH2CH2OCH3, O(CH2)2SCH3, O(CH2)2ON(CH3)2, O(CH2)2O(CH2)2N(CH3)2, 그리고 OCH2C(=O)-N(H)CH3 ("NMA").
특정 구체예들에서, 2'-치환된 뉴클레오시드는 다음에서 선택된 비-다리연결 2'-치환기를 당 모이어티를 포함한다: F, OCH3, 그리고 OCH2CH2OCH3.
특정 구체예들에서, 변형된 푸라노실 당모이어티 그리고 이러한 변형된 푸라노실 당 모이어티에 통합된 뉴클레오시드는 이성체 배위(configuration)에 의해 추가 특정된다. 예를 들면, 2'-데옥시푸라노실 당 모이어티는 자연 발생적 β-D-데옥시리보실 배위이외의 7가지 이성질체 배위로 존재할 수 있다. 이러한 변형된 당 모이어티는 가령, WO 2019/157531 (이의 전문이 본원 참고자료에 편입됨)에 기술된다. 2'-변형된 당 모이어티는 2'-데옥시푸라노실 당 모이어티에 대해 2'-위치에서 추가 입체중심을 가지고; 따라서, 이러한 당 모이어티는 총 16개의 가능한 입체 배위를 갖는다. 본원에서 기술된 2'-변형된 당 모이어티는 다른 언급이 없는 한, β-D-리보실 이성질체 배위로 존재한다.
특정 변형된 당 모이어티는 제 2 고리를 형성하기 위해 푸라노실 고리의 2개 원자를 연결하는 치환체를 포함하고, 이로 인하여 이환 당 모이어티가 형성된다. 이러한 특정 구체예들에서, 상기 이환 당 모이어티는 푸라노스 고리 원자의 4' 및 2' 원자 간에 다리를 포함한다. 이러한 4'에서 2'로의 다리연결 당 치환체의 예로는 다음이 내포되나, 이에 국한되지 않는다: 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2' ("LNA"), 4'-CH2-S-2', 4'-(CH2)2-O-2' ("ENA"), 4'-CH(CH3)-O-2' ("구속된 에틸" 또는 "cEt"로 지칭됨), 4'-CH2-O-CH2-2', 4'-CH2-N(R)-2', 4'-CH(CH2OCH3)-O-2' ("구속된 MOE" 또는 "cMOE") 그리고 이의 유사체들 (가령, Seth et al., U.S. 7,399,845, Bhat et al., U.S. 7,569,686, Swayze et al., U.S. 7,741,457, 그리고 Swayze et al., U.S. 8,022,193 참고), 4'-C(CH3)(CH3)-O-2' 그리고 이의 유사체들 (가령, Seth et al., U.S. 8,278,283 참고), 4'-CH2-N(OCH3)-2' 그리고 이의 유사체들 (가령, Prakash et al., U.S. 8,278,425 참고), 4'-CH2-O-N(CH3)-2' (가령, Allerson et al., U.S. 7,696,345 및 Allerson et al., U.S. 8,124,745 참고), 4'-CH2-C(H)(CH3)-2' (가령, Zhou, et al., J. Org. Chem.,2009, 74, 118-134 참고), 4'-CH2-C(=CH2)-2' 그리고 이의 유사체들 (가령, Seth et al., U.S. 8,278,426 참고), 4'C(RaRb)-N(R)-O-2', 4'-C(RaRb)-O-N(R)-2', 4'-CH2-O-N(R)-2', 그리고 4'-CH2-N(R)-O-2', 이때 각 R, Ra, 및 Rb 는 독립적으로, H, 보호기, 또는 C1-C12 알킬이다 (가령, Imanishi et al., U.S. 7,427,672 참고).
특정 구체예들에서, 이러한 4'에서 2'로의 다리는 다음에서 돌립적으로 선택된 1 ~ 4개의 연계된 기를 독립적으로 포함한다: -[C(Ra)(Rb)]n-, -[C(Ra)(Rb)]n-O-, C(Ra)=C(Rb)-, C(Ra)=N-, C(=NRa)-, -C(=O)-, -C(=S)-, -O-, -Si(Ra)2-, -S(=O)x-, 그리고 N(Ra)-;
이때:
x는 0, 1, 또는 2이며;
n은 1, 2, 3, 또는 4이며;
Ra 및 Rb 각각은 독립적으로, H, 보호기, 히드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 알리사이클(alicyclic) 라디칼, 치환된 C5-C7 알리사이클 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 술포닐 (S(=O)2-J1), 또는 술폭실 (S(=O)-J1)이며; 그리고
J1 및 J2 각각은 독립적으로, H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 아실, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬, 또는 보호기이다.
추가적인 이환 당 모이어티들은 당분야에 공지되어 있는데, 예를 들면, 다음을 참고한다: Freier et al., Nucleic Acids Research, 1997, 25(22), 4429-4443, Albaek et al., J. Org. Chem., 2006, 71, 7731-7740, Singh et al., Chem. Commun., 1998, 4, 455-456; Koshkin et al., Tetrahedron, 1998, 54, 3607-3630; Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8, 2219-2222; Singh et al., J. Org. Chem., 1998, 63, 10035-10039; Srivastava et al., J. Am. Chem. Soc., 2007, 129, 8362-8379;Wengel et a., U.S. 7,053,207; Imanishi et al., U.S. 6,268,490; Imanishi et al. U.S. 6,770,748; Imanishi et al., U.S. RE44,779; Wengel et al., U.S. 6,794,499; Wengel et al., U.S. 6,670,461; Wengel et al., U.S. 7,034,133; Wengel et al., U.S. 8,080,644; Wengel et al., U.S. 8,034,909; Wengel et al., U.S. 8,153,365; Wengel et al., U.S. 7,572,582; Ramasamy et al., U.S. 6,525,191; Torsten et al., WO 2004/106356; Wengel et al., WO 1999/014226; Seth et al., WO 2007/134181; Seth et al., U.S. 7,547,684; Seth et al., U.S. 7,666,854; Seth et al., U.S. 8,088,746; Seth et al., U.S. 7,750,131; Seth et al., U.S. 8,030,467; Seth et al., U.S. 8,268,980; Seth et al., U.S. 8,546,556; Seth et al., U.S. 8,530,640; Migawa et al., U.S. 9,012,421; Seth et al., U.S. 8,501,805; 그리고 U.S. 특허 공개 번호 Allerson et al., US2008/0039618 및 Migawa et al., US2015/0191727.
특정 구체예들에서, 특정 구체예들에서, 이환 당 모이어티와 이러한 이환 당 모이어티에 편입되는 뉴클레오시드는 이성체 배위에 의해 추가 특정된다. 예를 들면, LNA 뉴클레오시드 (본원에 기술된)는 α-L 배위 또는 β-D 배위로 존재할 수 있다.
α-L-메틸렌옥시 (4'-CH2-O-2') 또는 α-L-LNA 이환 뉴클레오시드는 안티센스 활성을 나타낸 올리고뉴클레오티드 (Frieden et al., Nucleic Acids, 2003, 21, 6365-6372)에 통합되었다. 여기에서, 이환 뉴클레오사이드의 일반적인 설명에는 이들 두 이성질체 배위가 모두 내포된다. 특정 이환식 뉴클레오사이드(예를 들어, LNA 또는 cEt)의 위치가 본원의 예시된 구체예들에서 확인되는 경우, 달리 명시되지 않는 한, 이들은 β-D 배위에 있다.
특정 구체예들에서, 변형된 당 모이어티는 하나 또는 그 이상의 비-다리연결 당 치환체와 하나 또는 그 이상의 다리연결 당 치환체 (가령, 5'-치환된, 그리고 4'-2' 다리연결된 당)를 포함한다.
특정 구체예들에서, 변형된 당 모이어티는 당 대체물이다. 이러한 특정 구체예들에서, 상기 당 모이어티의 산소 원자는 가령, 황, 탄소 또는 질소 원자로 대체된다. 이러한 특정 구체예들에서, 이러한 변형된 당 모이어티는 본원에 기술된 바와 같이, 다리연결 치환체 및/또는 비-다리연결 치환체를 또한 포함한다. 예를 들면, 특정 당 대체물은 4'-황 원자, 2'-위치 (가령, Bhat et al., U.S. 7,875,733 및 Bhat et al., U.S. 7,939,677) 및/또는 5' 위치를 포함한다.
특정 구체예들에서, 당 대체물은 5개 이외의 원자를 갖는 고리를 포함한다. 예를 들면, 특정 구체예들에서, 당 대체물은 6-구성원의 테트라하이드로피란 ("THP")을 포함한다. 이러한 테트라하이드로피란은 추가 변형되거나, 또는 치환될 수 있다. 이러한 변형된 테트라하이드로피란을 포함하는 뉴클레오시드에는 헥시톨 핵산 ("HNA"), 아니톨 핵산 ("ANA"), 만니톨 핵산 ("MNA") (가령, Leumann, CJ. Bioorg. & Med. Chem. 2002, 10, 841-854 참고), 플루오르 HNA:
("F-HNA", 가령, Swayze et al., U.S. 8,088,904; Swayze et al., U.S. 8,440,803; Swayze et al., U.S. 8,796,437; 및 Swayze et al., U.S. 9,005,906; F-HNA는 또한 F-THP 또는 3'-플루오르 테트라하이드로피란으로도 지칭될 수 있음), 그리고 추가적으로 변형된, 다음 식을 포함하는 THP 화합물들을 포함하는 뉴클레오시드가 내포되나, 이에 국한되지 않는다:
이때, 상기 변형된 THP 뉴클레오시드 각각에 대해 독립적으로:
Bx는 핵염기 모이어티이고;
T3 및 T4는 각각 독립적으로, 상기 변형된 THP 뉴클레오시드를 올리고뉴클레오티드의 나머지에 연계시키는 뉴클레오시드간 연계기이거나, 또는 T3 및 T4 중 하나는 상기 변형된 THP 뉴클레오시드를 올리고뉴클레오티드의 나머지에 연계시키는 뉴클레오시드간 연계기이며, T3 및 T4 중 나머지 하나는 H, 히드록실 보호기, 연계된 콘쥬게이트 기, 또는 5' 또는 3'-말단 기이며;
q1, q2, q3, q4, q5, q6 및 q7은 각각 독립적으로, H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐, 또는 치환된 C2-C6 알키닐이며; 그리고
R1 및 R2는 각각 독립적으로 다음중에서 선택된다: 수소, 할로겐, 치환된 또는 치환안된 알콕시, NJ1J2, SJ1, N3, OC(=X)J1, OC(=X)NJ1J2, NJ3C(=X)NJ1J2, 그리고 CN, 이때 X는 O, S 또는 NJ1이며, 그리고 각 J1, J2, 및 J3은 독립적으로, H 또는 C1-C6 알킬이다.
특정 구체예들에서, 변형된 THP 뉴클레오시드가 제공되는데, 이때 q1, q2, q3, q4, q5, q6 및 q7은 각각 H이다. 특정 구체예들에서, q1, q2, q3, q4, q5, q6 및 q7중 적어도 하나는 H 이외의 것이다. 특정 구체예들에서, q1, q2, q3, q4, q5, q6 및 q7중 적어도 하나는 메틸이다. 특정 구체예들에서, 변형된 THP 뉴클레오시드가 제공되며, 이때 R1 및 R2 중 하나는 F이다. 특정 구체예들에서, R1은 F이며, R2는 H이다. 특정 구체예들에서, R1은 메톡시이고, R2는 H이고, 그리고 특정 구체예들에서, R1은 메톡시에톡시이고, R2는 H이다.
특정 구체예들에서, 당 대체물은 5개 이상의 원자와 하나 이상의 헤테로원자를 갖는 고리를 포함한다. 예를 들면, 모르폴리노 당 모이어티를 포함하는 뉴클레오시드, 그리고 올리고뉴클레오티드에서 이의 용도는 보고된 바 있다 (가령, Braasch et al., Biochemistry, 2002, 41, 4503-4510 and Summerton et al., U.S. 5,698,685; Summerton et al., U.S. 5,166,315; Summerton et al., U.S. 5,185,444; 및 Summerton et al., U.S. 5,034,506 참고). 본원에서 사용된 바와 같이, 용어 "모르폴리노(morpholino)"란 다음의 구조를 갖는 당 대체물을 의미한다:
특정 구체예들에서, 모르폴리노는 예를 들면, 상기 모르폴리노 구조로부터 다양한 치환기를 추가하거나, 또는 대체시킴으로써 변형될 수 있다. 이러한 당 대체물을 본원에서 "변형된 모르폴리노"라고 지칭한다.
특정 구체예들에서, 당 대체물은 비환형(acyclic) 모이어티를 포함한다. 이러한 비환형 당 대체물을 포함하는 뉴클레오시드 및 올리고뉴클레오티드의 예로는 다음이 내포되나, 이에 국한되지 않는다: 펩티드 핵산 ("PNA"), 비환형 부틸 핵산 (가령, Kumar et al., Org. Biomol. Chem., 2013, 11, 5853-5865), 그리고 Manoharan et al., WO2011/133876에서 기술된 뉴클레오시드 및 올리고뉴클레오티드.
변형된 뉴클레오시드에 이용될 수 있는 기타 많은 이환 및 삼환 당, 그리고 당 대체물 고리 시스템이 당분야에 공지되어 있다.
2.
특정 변형된 핵염기
특정 구체예들에서, 변형된 올리고뉴클레오티드는 변형안된 핵염기를 포함하는 하나 또는 그 이상의 뉴클레오시드를 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 변형된 핵염기를 포함하는 하나 또는 그 이상의 뉴클레오시드를 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 핵염기를 포함하지 않는 하나 또는 그 이상의 뉴클레오시드를 포함하는데, 이는 무염기 뉴클레오시드로 지칭된다.
특정 구체예들에서, 변형된 핵염기는 다음에서 선택된다: 5-치환된 피리미딘, 6-아자피리미딘, 알킬 또는 알키닐 치환된 피리미딘, 알킬 치환된 퓨린, 그리고 N-2, N-6 및 O-6 치환된 퓨린. 특정 구체예들에서, 변형된 핵염기는 다음에서 선택된다: 2-아미노프로필아데닌, 5-하이드록시메틸 시토신, 산틴, 하이포산틴, 2-아미노아데닌, 6-N-메틸구아닌, 6-N-메틸아데닌, 2-프로필아데닌, 2-티오우라실, 2-티오티민 및 2-티오시토신, 5-프로피닐 (-C≡C-CH3) 우라실, 5-프로피닐시토신, 6-아조우라실, 6-아조시토신, 6-아조티민, 5-리보실우라실 (슈도우라실), 4-티오우라실, 8-할로, 8-아미노, 8-티올, 8-티오알킬, 8-히드록실, 8-아자 및 기타 8-치환된 퓨린, 5-할로, 구체적으로 5-브로모, 5-트리플루오르메틸, 5-할로우라실, 그리고 5-할로시토신, 7-메틸구아닌, 7-메틸아데닌, 2-F-아데닌, 2-아미노아데닌, 7-데아자구아닌, 7-데아자아데닌, 3-데아자구아닌, 3-데아자아데닌, 6-N-벤조일아데닌, 2-N-이소부티릴구아닌, 4-N-벤조일시토신, 4-N-벤조일우라실, 5-메틸 4-N-벤조일시토신, 5-메틸 4-N-벤조일우라실, 범용 염기, 소수성 염기, 잡다한(promiscuous) 염기, 측쇄-확장된 염기, 그리고 플루오르화된 염기. 추가 변형된 핵염기에는 삼환 피리미딘, 이를 테면,1,3-디아자펜옥사진-2-온, 1,3-디아자페노티아진-2-온 및 9-(2-아미노에톡시)-1,3-디아자펜옥사진-2-온 (G-클램프(clamp))가 내포된다. 변형된 핵염기에는 퓨린 또는 피리미딘 염기가 다른 헤테로사이클, 예를 들면 7-데아자-아데닌, 7-데아자구아노신, 2-아미노피리딘 및 2-피리돈으로 대체된 것들이 또한 내포될 수 있다. 추가 핵염기에는 Merigan et al., U.S. 3,687,808에서 기술된 것들, The Concise Encyclopedia Of Polymer Science And Engineering, Kroschwitz, J.I., Ed., John Wiley & Sons, 1990, 858-859에서 기술된 것들; Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613; Sanghvi, Y.S., Chapter 15, Antisense Research and Applications, Crooke, S.T. and Lebleu, B., Eds., CRC Press, 1993, 273-288에서 기술된 것들; 그리고 Chapters 6 and 15, Antisense Drug Technology, Crooke S.T., Ed., CRC Press, 2008, 163-166 and 442-443에서 기술된 것들이 내포된다.
상기 기술된 변형된 핵염기 뿐만 아니라 기타 변형된 핵염기들의 특정 제조를 교시하는 공개물에는 다음의 것들이 내포되나, 이에 국한되지 않는다: Manoharan et al., US2003/0158403; Manoharan et al., US2003/0175906; Dinh et al., U.S. 4,845,205; Spielvogel et al., U.S. 5,130,302; Rogers et al., U.S. 5,134,066; Bischofberger et al., U.S. 5,175,273; Urdea et al., U.S. 5,367,066; Benner et al., U.S. 5,432,272; Matteucci et al., U.S. 5,434,257; Gmeiner et al., U.S. 5,457,187; Cook et al., U.S. 5,459,255; Froehler et al., U.S. 5,484,908; Matteucci et al., U.S. 5,502,177; Hawkins et al., U.S. 5,525,711; Haralambidis et al., U.S. 5,552,540; Cook et al., U.S. 5,587,469; Froehler et al., U.S. 5,594,121; Switzer et al., U.S. 5,596,091; Cook et al., U.S. 5,614,617; Froehler et al., U.S. 5,645,985; Cook et al., U.S. 5,681,941; Cook et al., U.S. 5,811,534; Cook et al., U.S. 5,750,692; Cook et al., U.S. 5,948,903; Cook et al., U.S. 5,587,470; Cook et al., U.S. 5,457,191; Matteucci et al., U.S. 5,763,588; Froehler et al., U.S. 5,830,653; Cook et al., U.S. 5,808,027; Cook et al., 6,166,199; 그리고 Matteucci et al., U.S. 6,005,096.
3.
특정 변형된 뉴클레오시드간 링키지
특정 구체예들에서, 변형된 올리고뉴클레오티드의 뉴클레오시드들은 임의의 뉴클레오시드간 링키지를 이용하여 함께 연계될 수 있다. 뉴클레오사이드간 연계기들의 두 가지 주요 부류는 인 원자의 존재 또는 부재로 정의된다. 인-함유하는 대표적인 뉴클레오시드간 링키지에는 포스포디에스테르 결합 ("P(O2)=O") (변형안된 링키지 또는 자연 발생적 링키지로도 또한 지칭됨), 포스포트리에스테르, 메틸포스포네이트, 포스포라미데이트, 그리고 포스포로티오에이트 ("P(O2)=S"), 그리고 포스포로디티오에이트 ("HS-P=S")를 함유하는 포스포디에스테르가 내포되나, 이에 국한되지 않는다. 인-함유하지 않는 대표적 뉴클레오시드간 연계 기들에는 메틸렌메틸이미노 (-CH2-N(CH3)-O-CH2-), 티오디에스테르, 티오노카르바메이트(-O-C(=O)(NH)-S-); 실옥산 (-O-SiH2-O-); 및 N,N'-디메틸하이드라진 (-CH2-N(CH3)-N(CH3)-)이 내포되나, 이에 국한되지 않는다. 자연 발생적 포스포디에스테르 뉴클레오시드간 링키지와 비교하였을 때, 변형된 뉴클레오시드간 링키지를 이용하여 올리고뉴클레오티드의 뉴클레아제 저항성을 변경시키는데, 일반적으로 이 저항성을 증가시킬 수 있다. 특정 구체예들에서, 키랄 원자를 갖는 뉴클레오시드간 링키지는 라셈체 혼합물, 또는 별개의 거울상체(enantiomers)로 제조될 수 있다. 인-함유하는 뉴클레오시드간 링키지와 인-함유하지 않는 뉴클레오시드간 링키지를 제조하는 방법들은 당업자들에게 잘 공지되어 있다.
키랄 중심를 갖는 대표적인 뉴클레오시드간 링키지는 알킬포스포네이트 및 포스포로티오에이트가 내포되나, 이에 국한되지 않는다. 키랄 중심를 갖는 대표적인 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드는 스테레오랜덤 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드 집단, 또는 특정 입체화학적 배위의 포스포로티오에이트 링키지를 포함하는 변형된 올리고뉴클레오티드 집단으로 제조될 수 있다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 집단은 포스포로티오에이트 뉴클레오시드간 링키지를 포함하고, 이때 상기 포스포로티오에이트 뉴클레오시드간 링키지들은 모두 스테레오랜덤이다. 이러한 변형된 올리고뉴클레오티드는 각 포스포로티오에이트 링키지의 입체화학적 배위의 무작위 선별을 야기하는 합성 방법들을 이용하여 만들어질 수 있다. 그럼에도 불구하고, 당업자들이 잘 인지하는 바와 같이, 개별 각 올리고뉴클레오티드 분자의 개별 각 포스포로티오에이트는 특정된 입체배위를 갖는다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 집단은 독립적으로 선택된 특정 입체화학적 배위의 하나 또는 그 이상의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드에 대해 농축된다. 특정 구체예들에서, 상기 특정 포스포로티오에이트 링키지의 특정 배위는 이 집단에서 해당 분자의 적어도 65%로 존재한다. 특정 구체예들에서, 상기 특정 포스포로티오에이트 링키지의 특정 배위는 이 집단에서 해당 분자의 적어도 70%로 존재한다. 특정 구체예들에서, 상기 특정 포스포로티오에이트 링키지의 특정 배위는 이 집단에서 해당 분자의 적어도 80%로 존재한다. 특정 구체예들에서, 상기 특정 포스포로티오에이트 링키지의 특정 배위는 이 집단에서 해당 분자의 적어도 90%로 존재한다. 특정 구체예들에서, 상기 특정 포스포로티오에이트 링키지의 특정 배위는 이 집단에서 해당 분자의 적어도 99%로 존재한다. 이러한 키랄 풍부한, 변형된 올리고뉴클레오티드의 집단은 당분야에 공지된 합성 방법들, 가령, Oka et al., JACS 125, 8307 (2003), Wan et al. Nuc. Acid. Res. 42, 13456 (2014), 그리고 WO 2017/015555에 기술된 방법들을 이용하여 만들어질 수 있다. 특정 구체예들에서, 변형된 올리고뉴클레오티드 집단은 (Sp) 배위의 적어도 하나의 표시된 포스포로티오에이트를 갖는 변형된 올리고뉴클레오티드로 농축된다. 특정 구체예들에서, 변형된 올리고뉴클레오티드 집단은 (Rp) 배위의 적어도 하나의 포스포로티오에이트를 갖는 변형된 올리고뉴클레오티드로 농축된다. 특정 구체예들에서, (Rp) 및/또는 (Sp) 포스포로티오에이트를 포함하는 변형된 올리고뉴클레오티드는 차례로 각각 다음 식의 하나 또는 그 이상을 포함하고, 이때 "B"는 핵염기를 나타낸다:
달리 명시되지 않는 한, 본원에 기술된 변형된 올리고뉴클레오티드의 키랄 뉴클레오시드간 링키지는 스테레오랜덤일 수 있거나, 또는 특정 입체화학적 배위일 수 있다.
중성 뉴클레오시드간 링키지에는 포스포트리에스테르, 메틸포스포네이트, MMI (3'-CH2-N(CH3)-O-5'), 아미드-3 (3'-CH2-C(=O)-N(H)-5'), 아미드-4 (3'-CH2-N(H)-C(=O)-5'), 포름아세탈 (3'-O-CH2-O-5'), 메톡시프로필 (MOP), 그리고 티오포름아세탈 (3'-S-CH2-O-5')이 내포되나, 이에 국한되지 않는다. 추가적인 중성 뉴클레오시드간 링키지에는 실옥산 (디알킬실옥산), 카르복실레이트 에스테르, 카르복사미드, 술파이드, 술포네이트 에스테르 및 아미드를 포함하는 비-이온성 링키지가 내포된다 (예를 들면: Carbohydrate Modifications in Antisense Research; Y.S. Sanghvi and P.D. Cook, Eds., ACS Symposium Series 580; Chapters 3 and 4, 40-65 참고). 추가 중성 뉴클레오시드간 링키지에는 혼합형 N, O, S 및 CH2 구성요소 부분을 포함하는 비-이온성 링키지가 내포된다. 특정 구체예들에서, 중성 뉴클레오시드간 링키지는 WO 2021/030778 (본원의 참고자료에 편입됨)에 기술된 임의의 것이다.
B.
특정 모티프
특정 구체예들에서, 변형된 올리고뉴클레오티드는 변형된 당 모이어티를 포함하는 하나 또는 그 이상의 변형된 뉴클레오시드를 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 변형된 핵염기를 포함하는 하나 또는 그 이상의 변형된 뉴클레오시드를 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 하나 또는 그 이상의 변형된 뉴클레오시드간 링키지를 포함한다. 이러한 구체예들에서, 상기 변형된 당 모이어티, 변형안된 당 모이어티, 그리고 상이하게 변형된 당 모이어티, 핵염기, 및/또는 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 패턴 또는 모티프를 특정한다. 특정 구체예들에서, 당 모이어티, 핵염기, 그리고 뉴클레오시드간 링키지의 패턴은 서로 각각 독립적이다. 따라서, 변형된 올리고뉴클레오티드는 이의 당 모티프, 핵염기 모티프 및/또는 뉴클레오시드간 링키지 모티프 (본원에서 이용된 바와 같이, 핵염기 모티프는 핵염기의 서열에 독립적인 핵염기 변형을 기술한다)에 의해 기술될 수 있다.
1.
특정 당 모티프
특정 구체예들에서, 올리고뉴클레오티드는 특정된 패턴 또는 당 모티프의 올리고뉴클레오티드 또는 이의 부분을 따라 배열된 변형된 당 및/또는 변형안된 당 모이어티의 하나 또는 그 이상의 유형을 포함한다. 특정 경우들에서, 이러한 당 모티프에는 본원에서 논의된 임의의 당 변형이 내포되나, 이에 국한되지 않는다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머 모티프 (두 개의 외부 영역 또는 "윙(wings)"에 의해 특정됨)와 중심 영역 또는 내부 영역 또는 "갭(gap)"을 갖는다. 갭머 모티프의 세 가지 영역 (5'-윙, 갭, 그리고 3'-윙)은 뉴클레오시드의 연접한 서열을 형성하고, 이때 상기 각 윙의 뉴클레오시드의 당 모이어티들중 적어도 일부는 상기 갭의 뉴클레오시드의 당 모이어티의 적어도 일부와 상이하다. 구체적으로, 상기 갭에 가장 근접한 윙의 뉴클레오시드의 적어도 당 모이어티 (5'-윙의 3'-가장 멀리 있는 뉴클레오시드와 3'-윙의 5'-최근접 뉴클레오시드)는 이웃한 갭 뉴클레오시드의 당 모이어티와 상이하고, 따라서 이들 윙과 갭 사이에 경계 (즉, 윙/갭 졍션)를 특정한다. 특정 구체예들에서, 상기 갭 안에 당 모이어티는 서로 동일하다. 특정 구체예들에서, 상기 갭에는 이 갭의 하나 또는 그 이상의 다른 뉴클레오시드의 당 모이어티와 싱이한, 당 모이어티를 갖는 하나 또는 그 이상의 뉴클레오시드가 내포된다. 특정 구체예들에서, 두 개 윙의 당 모티프는 서로 동일하다 (대칭 갭머). 특정 구체예들에서, 5'-윙의 당 모티프는 3'-윙의 당 모티프와 상이하다 (비대칭 갭머).
특정 구체예들에서, 갭머의 윙은 1-6개의 뉴클레오시드를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 각 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 적어도 두 개의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 적어도 세 개의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 적어도 네 개의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 적어도 다섯 개의 뉴클레오시드는 변형된 당 모이어티를 포함한다.
특정 구체예들에서, 갭머의 갭은 7-12개의 뉴클레오시드를 포함한다. 특정 구체예들에서, 갭머의 갭의 각 뉴클레오시드는 2'-데옥시리보실 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 갭의 각 뉴클레오시드는 2'-β-D-데옥시리보실 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 갭의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 갭의 적어도 하나의 뉴클레오시드는 2'-OMe 당 모이어티를 포함한다.
특정 구체예들에서, 상기 갭머는 데옥시 갭머이다. 특정 구체예들에서, 각 윙/갭 졍션의 갭 상의 뉴클레오시드는 2'-데옥시리보실 당 모이어티를 포함하고, 각 윙/갭 졍션의 윙 상의 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 상기 갭의 각 뉴클레오시드는 2'-데옥시리보실 당 모이어티를 포함한다. 특정 구체예들에서, 갭머의 각 윙의 각 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 상기 갭의 하나의 뉴클레오시드는 변형된 당 모이어티를 포함하고, 상기 갭의 각 나머지 뉴클레오시드는 2'-데옥시리보실 당 모이어티를 포함한다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 완전한 변형된 당 모티프를 갖는 부분을 포함하거나, 또는 이 부분으로 구성된다. 이러한 구체예들에서, 상기 변형된 올리고뉴클레오티드의 완전하게 변형된 부분의 각 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 전체 변형된 올리고뉴클레오티드의 각 뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 완전한 변형된 당 모티프를 갖는 부분을 포함하거나, 또는 이 부분으로 구성되며, 이때 완전한 변형된 부분내 각 뉴클레오시드는 동일하게 변형된 당 모이어티를 포함하며, 이는 본원에서 균일하게 변형된 당 모티프로 지칭된다. 특정 구체예들에서, 완전한 변형된 올리고뉴클레오티드는 균일하게(uniformly) 변형된 올리고뉴클레오티드이다. 특정 구체예들에서, 균일하게 변형된 올리고뉴클레오티드의 각 뉴클레오시드는 동일한 2'-변형을 포함한다.
본원에서, 갭머의 세 가지 영역의 길이(뉴클레오시드의 수)는 식 [5'-윙에서 뉴클레오시드의 #] - [갭에서 뉴클레오시드의 #] - [3'-윙에서 뉴클레오시드의 #]을 이용하여 제공될 수 있다. 따라서, 5-10-5 갭머는 각 윙에서 5개의 연계된 뉴클레오시드, 그리고 갭에서 10개의 연계된 뉴클레오시드로 구성된다. 이러한 명명법이 특이적 변형에 따르는 경우, 이 변형은 각 윙에서 각 당 모이어티에서의 변형이며, 갭 뉴클레오시드는 2'-β-D-데옥시리보실 당 모이어티를 포함한다. 따라서, 5-10-5 MOE 갭머는5'-윙에 5개의 연계된 2'-MOE 뉴클레오시드, 갭에 10개의 연계된 2'-β-D-데옥시뉴클레오시드, 그리고 3'-윙에 5개의 연계된 2'-MOE 뉴클레오시드로 구성된다. 3-10-3 cEt 갭머는 5'-윙에서 3개의 연계된 cEt 뉴클레오시드, 갭에서 10개의 연계된 2'-β-D-데옥시뉴클레오시드, 그리고 3'-윙에서 3개의 연계된 cEt 뉴클레오시드로 구성된다. 5-8-5 갭머는 5'-윙에서 변형된 당 모이어티를 포함하는 5개의 연계된 뉴클레오시드, 갭에서 8개의 연계된 2'-β-D-데옥시뉴클레오시드, 그리고 3'-윙에서 변형된 당 모이어티를 포함하는 5개의 연계된 뉴클레오시드로 구성된다. 5-8-5 또는 5-8-4 혼합형 윙 갭머는 5'-윙 및/또는 3'-윙에 적어도 두 개의 상이한 변형된 당 모이어티를 갖는다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 6-10-4 MOE 갭머이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 5-8-4 MOE 갭머이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 X-Y-Z MOE 갭머이며, 이때 X 및 Z는 1개, 2개, 3개, 4개, 5개, 6개, 또는 7개의 연계된 2'-MOE 뉴클레오시드로부터 독립적으로 선택되며, Y는 7개, 8개, 9개, 10개, 또는 11개의 연계된 데옥시뉴클레오시드에서 선택된다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 다음에서 선택된 당 모티프를 갖는다 (5'에서 3'로): eeeeeddddddddkkee 또는 eeeeedyddddddkkee, 이때 'd'는 2'-데옥시리보실 당 모이어티를 나타내고, 'e'는 2'-MOE 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'y'는 2'-OMe 당 모이어티를 나타낸다.
2.
특정 핵염기 모티프
특정 구체예들에서, 올리고뉴클레오티드는 특정된 패턴 또는 모티프에서 올리고뉴클레오티드 또는 이의 부분을 따라 배열된 변형된 핵염기 및/또는 변형안된 핵염기를 포함한다. 특정 구체예들에서, 각 핵염기는 변형된다. 특정 구체예들에서, 상기 핵염기중 어느 것도 변형되지 않는다. 특정 구체예들에서, 각 퓨린 또는 각 피리미딘은 변형된다. 특정 구체예들에서, 각 아데닌은 변형된다. 특정 구체예들에서, 각 구아닌은 변형된다. 특정 구체예들에서, 각 티민은 변형된다. 특정 구체예들에서, 각 우라실은 변형된다. 특정 구체예들에서, 각 시토신은 변형된다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 시토신 핵염기중 일부 또는 모두는 5-메틸 시토신이다. 특정 구체예들에서, 모든 시토신 핵염기는 5-메틸 시토신이며, 상기 변형된 올리고뉴클레오티드의 다른 핵염기 모두는 변형안된 핵염기이다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 변형된 핵염기의 블록(block)을 포함한다. 이러한 특정 구체예들에서, 상기 블록은 상기 올리고뉴클레오티드의 3'-단부에 있다. 특정 구체예들에서, 상기 블록은 상기 올리고뉴클레오티드의 3'-단부의 3개 뉴클레오시드 내에 있다. 특정 구체예들에서, 상기 블록은 상기 올리고뉴클레오티드의 5'-단부에 있다. 특정 구체예들에서, 상기 블록은 상기 올리고뉴클레오티드의 5'-단부의 3개 뉴클레오시드 내에 있다.
특정 구체예들에서, 갭머 모티프를 갖는 올리고뉴클레오티드는 변형된 핵염기를 포함하는 뉴클레오시드를 포함한다. 이러한 특정 구체예들에서, 변형된 핵염기를 포함하는 하나의 뉴클레오시드는 갭머 모티프를 갖는 올리고뉴클레오티드의 중심 갭에 있다. 이러한 특정 구체예들에서, 전술한 뉴클레오시드의 당 모이어티는 2'-데옥시리보실 당 모이어티이다. 특정 구체예들에서, 상기 변형된 핵염기는 다음에서 선택된다: 2-티오피리미딘 및 5-프로피네피리미딘.
3.
특정 뉴클레오시드간 링키지 모티프
특정 구체예들에서, 올리고뉴클레오티드는 특정된 패턴 또는 모티프에서 올리고뉴클레오티드 또는 이의 부분을 따라 배열된 변형된 뉴클레오시드간 링키지 및/또는 변형안된 뉴클레오시드간 링키지를 포함한다. 특정 구체예들에서, 각 뉴클레오시드간 연계기는 포스포디에스테르 뉴클레오시드간 링키지 (P(O2)=O)이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 연계기는 포스포로티오에이트 뉴클레오시드간 링키지 (P(O2)=S)이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지에서 독립적으로 선택된다. 특정 구체예들에서, 각 포스포로티오에이트 뉴클레오시드간 링키지는 스테레오랜덤 포스포로티오에이트, (Sp) 포스포로티오에이트, 그리고 (Rp) 포스포로티오에이트에서 독립적으로 선택된다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 당 모티프는 갭머이며, 상기 갭 안에 뉴클레오시드간 링키지는 모두 변형된다. 이러한 특정 구체예들에서, 윙에서 일부 또는 전부의 뉴클레오시드간 링키지는 변형안된 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 말단 뉴클레오시드간 링키지는 변형된다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 당 모티프는 갭머이며, 그리고 상기 뉴클레오시드간 링키지 모티프는 적어도 하나의 윙에 적어도 하나의 포스포디에스테르 뉴클레오시드간 링키지를 포함하고, 이때 상기 적어도 하나의 포스포디에스테르 링키지는 말단 뉴클레오시드간 링키지가 아니며, 그리고 나머지 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이다. 이러한 특정 구체예들에서, 모든 포스포로티오에이트 링키지는 스테레오랜덤이다. 특정 구체예들에서, 윙에서 모든 포스포로티오에이트 링키지는 (Sp) 포스포로티오에이트이며, 그리고 상기 갭은 적어도 하나의 Sp, Sp, Rp 모티프를 포함한다. 특정 구체예들에서, 모든 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지 또는 포스포로티오에이트 뉴클레오시드간 링키지이며, 상기 키랄 모티프는 다음과 같다 (5'에서 3'로): Sp-o-o-o-Sp-Sp-Sp-Rp-Sp-Sp-Rp-Sp-Sp-Sp-Sp-Sp-Sp-Sp-Sp 또는 Sp-o-o-o-Sp-Sp-Sp-Rp-Sp-Sp-Sp-Sp-Sp-Sp-Sp-Sp-Sp-Sp-Sp, 이때 각 'Sp'는 (Sp) 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 'Rp'는 Rp 뉴클레오시드간 링키지이며, 각 'o'는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 집단은 이러한 뉴클레오시드간 링키지 모티프를 포함하는 변형된 올리고뉴클레오티드에 대해 농축된다.
특정 구체예들에서, 변형된 올리고뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 (5'에서 3'로) 다음의 뉴클레오시드간 링키지 모티프: sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 (5'에서 3'로) 다음의 뉴클레오시드간 링키지 모티프:sssosssssssssssosss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 (5'에서 3'로) 다음의 뉴클레오시드간 링키지 모티프: sssosssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
C.
특정 길이
활성을 제거하지 않고, 올리고뉴클레오티드의 길이를 늘리거나 또는 줄이는 것이 가능하다. 예를 들면, Woolf et al. (Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992)에서, 13-25개 길이의 핵염기로 된 일련의 올리고뉴클레오티드를 난모세포 주입 모델에서 표적 핵산의 절단을 유도하는 능력에 대해 테스트했다. 올리고뉴클레오티드의 단부 부근에 8개 또는 11개의 미스매치 염기를 갖는 길이가 25개의 핵염기인 올리고뉴클레오티드는 비록 미스매치를 포함하지 않는 올리고뉴클레오티드보다 정도는 적지만, 표적 핵산의 특이적 절단을 지시할 수 있었다. 유사하게, 표적 특이적 분할은 1개 또는 3개의 미스매치를 갖는 것들을 비롯하여, 13개 핵염기 올리고뉴클레오티드를 이용하여 얻었다.
특정 구체예들에서, 올리고뉴클레오티드 (변형된 올리고뉴클레오티드를 비롯한)는 다양한 길이 범위중 임의의 길이를 가질 수 있다. 특정 구체예들에서, 올리고뉴클레오티드는 X 내지 Y개의 연계된 뉴클레오시드로 구성되며, 여기에서 X는 해당 범위에서 뉴클레오시드의 최소 숫자를 나타내며, Y는 해당 범위에서 뉴클레오시드의 최대 숫자를 나타낸다. 이러한 특정 구체예들에서, X 및 Y는 X≤Y인 조건에서, 각 독립적으로 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 그리고 50에서 선택된다. 예를 들면, 특정 구체예들에서, 올리고뉴클레오티드는 12 ~ 13개, 12 ~ 14개, 12 ~ 15개, 12 ~ 16개, 12 ~ 17개, 12 ~ 18개, 12 ~ 19개, 12 ~ 20개, 12 ~ 21개, 12 ~ 22개, 12 ~ 23개, 12 ~ 24개, 12 ~ 25개, 12 ~ 26개, 12 ~ 27개, 12 ~ 28개, 12 ~ 29개, 12 ~ 30개, 13 ~ 14개, 13 ~ 15개, 13 ~ 16개, 13 ~ 17개, 13 ~ 18개, 13 ~ 19개, 13 ~ 20개, 13 ~ 21개, 13 ~ 22개, 13 ~ 23개, 13 ~ 24개, 13 ~ 25개, 13 ~ 26개, 13 ~ 27개, 13 ~ 28개, 13 ~ 29개, 13 ~ 30개, 14 ~ 15개, 14 ~ 16개, 14 ~ 17개, 14 ~ 18개, 14 ~ 19개, 14 ~ 20개, 14 ~ 21개, 14 ~ 22개, 14 ~ 23개, 14 ~ 24개, 14 ~ 25개, 14 ~ 26개, 14 ~ 27개, 14 ~ 28개, 14 ~ 29개, 14 ~ 30개, 15 ~ 16개, 15 ~ 17개, 15 ~ 18개, 15 ~ 19개, 15 ~ 20개, 15 ~ 21개, 15 ~ 22개, 15 ~ 23개, 15 ~ 24개, 15 ~ 25개, 15 ~ 26개, 15 ~ 27개, 15 ~ 28개, 15 ~ 29개, 15 ~ 30개, 16 ~ 17개, 16 ~ 18개, 16 ~ 19개, 16 ~ 20개, 16 ~ 21개, 16 ~ 22개, 16 ~ 23개, 16 ~ 24개, 16 ~ 25개, 16 ~ 26개, 16 ~ 27개, 16 ~ 28개, 16 ~ 29개, 16 ~ 30개, 17 ~ 18개, 17 ~ 19개, 17 ~ 20개, 17 ~ 21개, 17 ~ 22개, 17 ~ 23개, 17 ~ 24개, 17 ~ 25개, 17 ~ 26개, 17 ~ 27개, 17 ~ 28개, 17 ~ 29개, 17 ~ 30개, 18 ~ 19개, 18 ~ 20개, 18 ~ 21개, 18 ~ 22개, 18 ~ 23개, 18 ~ 24개, 18 ~ 25개, 18 ~ 26개, 18 ~ 27개, 18 ~ 28개, 18 ~ 29개, 18 ~ 30개, 19 ~ 20개, 19 ~ 21개, 19 ~ 22개, 19 ~ 23개, 19 ~ 24개, 19 ~ 25개, 19 ~ 26개, 19 ~ 29개, 19 ~ 28개, 19 ~ 29개, 19 ~ 30개, 20 ~ 21개, 20 ~ 22개, 20 ~ 23개, 20 ~ 24개, 20 ~ 25개, 20 ~ 26개, 20 ~ 27개, 20 ~ 28개, 20 ~ 29개, 20 ~ 30개, 21 ~ 22개, 21 ~ 23개, 21 ~ 24개, 21 ~ 25개, 21 ~ 26개, 21 ~ 27개, 21 ~ 28개, 21 ~ 29개, 21 ~ 30개, 22 ~ 23개, 22 ~ 24개, 22 ~ 25개, 22 ~ 26개, 22 ~ 27개, 22 ~ 28개, 22 ~ 29개, 22 ~ 30개, 23 ~ 24개, 23 ~ 25개, 23 ~ 26개, 23 ~ 27개, 23 ~ 28개, 23 ~ 29개, 23 ~ 30개, 24 ~ 25개, 24 ~ 26개, 24 ~ 27개, 24 ~ 28개, 24 ~ 29개, 24 ~ 30개, 25 ~ 26개, 25 ~ 27개, 25 ~ 28개, 25 ~ 29개, 25 ~ 30개, 26 ~ 27개, 26 ~ 28개, 26 ~ 29개, 26 ~ 30개, 27 ~ 28개, 27 ~ 29개, 27 ~ 30개, 28 ~ 29개, 28 ~ 30개, 또는 29 ~ 30개의 연계된 뉴클레오시드로 구성된다.
D.
특정 변형된 올리고뉴클레오티드
특정 구체예들에서, 상기 변형 (당, 핵염기, 뉴클레오시드간 링키지)이 변형된 올리고뉴클레오티드에 통합된다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 이들의 변형 모티프 및 전체 길이에 의해 특징화된다. 특정 구체예들에서, 이러한 매개변수들은 서로 각각 독립적이다. 따라서, 달리 명시되지 않는 한, 갭머 당 모티프를 갖는 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 변형되거나, 또는 변형안될 수 있고, 이 당 변형의 갭머 변형 패턴을 따를 수도 있고, 또는 따르지 않을 수도 있다. 예를 들면, 당 갭머의 윙 영역내 뉴클레오시드간 링키지는 서로 동일하거나, 또는 상이할 수 있으며, 그리고 당 모티프의 갭 영역의 뉴클레오시드간 링키지와 동일하거나, 또는 상이할 수 있다. 마찬가지로, 이러한 당 갭머 올리고뉴클레오티드는 당 변형의 갭머 패턴과 독립적으로 하나 또는 그 이상의 변형된 핵염기를 포함할 수 있다. 달리 명시되지 않는 한, 모든 변형은 핵염기 서열과는 독립적이다.
E.
특정 변형된 올리고뉴클레오티드의 집단
집단의 변형된 올리고뉴클레오티드가 동일한 분자식을 갖는 변형된 올리고뉴클레오티드의 이 집단은 스테레오랜덤 집단 또는 키랄 풍부 집단일 수 있다. 상기 변형된 올리고뉴클레오티드 모두의 키랄 중심 모두는 스테레오랜덤 집단에서 스테레오랜덤이다. 키랄 풍부 집단에서, 적어도 하나의 특정 키랄 중심은 이 집단의 변형된 올리고뉴클레오티드에서 스테레오랜덤은 아니다. 특정 구체예들에서, 키랄 풍부 집단의 변형된 올리고뉴클레오티드는 β-D 리보실 당 모이어티에 대해 농축되며, 그리고 모든 포스포로티오에이트 뉴클레오시드간 링키지는 스테레오랜덤이다. 특정 구체예들에서, 키랄 풍부 집단의 변형된 올리고뉴클레오티드는 β-D 리보실 당 모이어티와 특정 입체화학적 배위의 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지 모두에 대해 농축된다.
F.
핵염기 서열
특정 구체예들에서, 올리고뉴클레오티드 (변형안된 올리고뉴클레오티드 또는 변형된 올리고뉴클레오티드)는 이들의 핵염기 서열에 의해 추가 기술된다. 특정 구체예들에서, 올리고뉴클레오티드는 제 2 올리고뉴클레오티드 또는 확인된 기준 핵산, 이를 테면, 표적 핵산에 대해 상보성인 핵염기 서열을 갖는다. 이러한 특정 구체예들에서, 올리고뉴클레오티드의 부분은 제 2 올리고뉴클레오티드 또는 확인된 기준 핵산, 이를 테면, 표적 핵산에 대해 상보성인 핵염기 서열을 갖는다. 특정 구체예들에서, 올리고뉴클레오티드의 일부 길이 또는 전체 길이의 핵염기 서열은 상기 제 2 올리고뉴클레오티드 또는 핵산, 이를 테면, 표적 핵산에 대해 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보적이다.
II.
특정 올리고머 화합물들
특정 구체예들에서, 올리고뉴클레오티드 (변형된 또는 변형안된) 및 임의선택적으로 하나 또는 그 이상의 콘쥬게이트 기 및/또는 말단 기로 구성된, 올리고머 화합물들이 본원에 제공된다. 콘쥬게이트 기는 하나 또는 그 이상의 콘쥬게이트 모이어티, 그리고 이 콘쥬게이트 모이어티를 상기 올리고뉴클레오티드에 연계시키는 콘쥬게이트 링커로 구성된다. 콘쥬게이트 기는 올리고뉴클레오티드의 한쪽-단부 또는 양-단부에 부착될 수 있거나, 및/또는 임의의 내부 위치에 부착될 수 있다. 특정 구체예들에서, 콘쥬게이트 기는 변형된 올리고뉴클레오티드의 뉴클레오시드의 2'-위치에 부착된다. 특정 구체예들에서, 올리고뉴클레오티드의 한 쪽 단부 또는 양쪽 단부에 부착된 콘쥬게이트 기는 말단 기이다. 이러한 특정 구체예들에서, 콘쥬게이트 기 또는 말단 기는 올리고뉴클레오티드의 3'-단부 및/또는 5'-단부에 부착된다. 이러한 특정 구체예들에서, 콘쥬게이트 기 (또는 말단 기)는 올리고뉴클레오티드의 5'-단부에 부착된다. 특정 구체예들에서, 콘쥬게이트 기는 올리고뉴클레오티드의 5'-단부 부근에 부착된다. 특정 구체예들에서, 콘쥬게이트 기 (또는 말단 기)는 리고뉴클레오티드의 5-단부에 부착된다. 특정 구체예들에서, 콘쥬게이트 기는 리고뉴클레오티드의 5-단부에 부착된다.
말단 기의 예시에는 콘쥬게이트 기, 캡핑(capping), 포스페이트 모이어티, 보호기, 변형된 또는 변형안된 뉴클레오시드, 그리고 독립적으로 변형된 또는 변형안된 두개 또는 그 이상의 뉴클레오시드가 내포되나, 이에 국한되지 않는다.
A.
특정 콘쥬게이트 기
특정 구체예들에서, 올리고뉴클레오티드는 하나 또는 그 이상의 콘쥬게이트 기에 공유적으로 부착된다. 특정 구체예들에서, 콘쥬게이트 기는 부착된 올리고뉴클레오티드의 속성, 이를 테면, 약력학, 약동학, 안정성, 결합, 흡수, 조직 분포, 세포 분포, 세포 흡수, 전하 및 제거를 비롯한, 그러나 이에 국한되지 않는 하나 또는 그 이상의 속성을 변형시킨다. 특정 구체예들에서, 콘쥬게이트 기는 부착된 올리고뉴클레오타이드에 새로운 속성, 가령, 올리고뉴클레오타이드의 검출을 가능하게 하는 형광단 또는 리포터기를 부여한다. 특정 콘쥬게이트 기 및 콘쥬게이트 모이어티들은 이미 기술된 바 있다: 예를 들면, 콜레스테롤 모이어티 (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556), 콜린산 (Manoharan et al., Bioorg. Med. Chem. Lett., 1994, 4, 1053-1060), 티오에테르, 가령, 헥실-S-트리틸티올 (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Bioorg. Med. Chem. Lett., 1993, 3, 2765-2770), 티오콜레스테롤 (Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538), 지방족쇄, 가령, 도-데칸-디올 또는 운데실 잔기 (Saison-Behmoaras et al., EMBO J., 1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), 인지질, 가령, 디-헥사데실-rac-글리세롤 또는 트리에틸암모늄 1,2-디-O-헥사데실-rac-글리세로-3-H-포스포네이트 (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783), 폴리아민 또는 폴리에틸렌 글리콜 쇄 (Manoharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973), 또는 아다만탄 아세트산 팔미틸 모이어티 (Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237), 옥타데실아민 또는 헥실아미노-카르보닐-옥시콜레스테롤 모이어티 (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937), 토코페롤 기 (Nishina et al., Molecular Therapy Nucleic Acids, 2015, 4, e220; 및 Nishina et al., Molecular Therapy, 2008, 16, 734-740), 또는 GalNAc 클러스터 (e.g., WO2014/179620).
1.
콘쥬게이트 모이어티
콘쥬게이트 모이어티에는 인터칼레이터(intercalators), 리포터 분자, 폴리아민, 폴리아미드, 펩티드, 탄수화물, 비타민 모이어티, 폴리에틸렌 글리콜, 티오에테르, 폴리에테르, 콜레스테롤, 티오콜레스테롤, 콜린산 모이어티, 엽산, 지질, 친유성 그룹, 인지질, 바이오틴, 페나진, 페난트리딘, 안트라퀴논, 아다만트 아크리딘, 플루오레세인, 로다민, 쿠마린, 형광단 및 염료가 내포되나, 이에 국한되지 않는다.
특정 구체예들에서, 콘쥬게이트 모이어티는 활성 약물 물질, 예를 들어, 아스피린, 와파린, 페닐부타존, 이부프로펜, 수프로펜, 펜부펜, 케토프로펜, (S)-(+)-프라노프로펜, 카르프로펜, 단실사르코신, 2,3,5-트리요오도벤조산, 핑골리모드, 플루페남산, 폴린산 산, 벤조티아디아지드, 클로로티아지드, 디아제핀, 인도-메티신, 바르비투르산염, 세팔로스포린, 술파제(sulfa drug), 항당뇨병제, 항균제 또는 항생제를 포함한다.
2.
콘쥬게이트 링커
콘쥬게이트 모이어티는 콘쥬게이트 링커를 통하여 올리고뉴클레오티드에 부착된다. 특정 올리고머 화합물들에서, 상기 콘쥬게이트 링커는 단일 화학 결합 (가령, 상기 콘쥬게이트 모이어티는 단일 결합을 통하여 리고뉴클레오티드에 바로 부착된다). 특정 구체예들에서, 상기 콘쥬게이트 링커는 쇄 구조, 이를 테면, 히드로카르빌 쇄, 또는 반복 단위의 올리고머, 이를 테면, 에틸렌 글리콜, 뉴클레오시드 또는 아미노산 단위를 포함한다.
특정 구체예들에서, 콘쥬게이트 링커는 알킬, 아미노, 옥소, 아미드, 디술파이드, 폴리에틸렌 글리콜, 에테르, 티오에테르, 및 히드록실아미노에서 선택된 하나 또는 그 이상의 기를 포함한다. 이러한 특정 구체예들에서, 상기 콘쥬게이트 링커는 알킬, 아미노, 옥소, 아미드 및 에테르 기에서 선택된 기를 포함한다. 특정 구체예들에서, 상기 콘쥬게이트 링커는 알킬과 아미드 기에서 선택된 기를 포함한다. 특정 구체예들에서, 상기 콘쥬게이트 링커는 알킬과 에테르 기에서 선택된 기를 포함한다. 특정 구체예들에서, 상기 콘쥬게이트 링커는 적어도 하나의 인(phosphorus) 모이어티를 포함한다. 특정 구체예들에서, 상기 콘쥬게이트 링커는 적어도 하나의 포스페이트 기를 포함한다. 특정 구체예들에서, 상기 콘쥬게이트 링커는 적어도 하나의 중성 연계기(linking group)를 포함한다.
특정 구체예들에서, 상기에서 기술된 콘쥬게이트 링커를 비롯한, 콘쥬게이트 링커는 이중기능성 연계 모이어티, 가령, 콘쥬게이트 기를 부모 화합물들, 이를 테면, 본원에서 제공되는 올리고뉴클레오티드에 부착시키는데 유용한 것으로 공지된 것들이다. 일반적으로, 이중기능성 연계 모이어티는 적어도 두 개의 기능성 기를 포함한다. 상기 기능성 기의 하나는 부모 화합물 상의 특정 부위에 결합하는 것이 선택되며, 다른 하나는 콘쥬게이트 기에 결합하는 것이 선택된다. 이중기능성 연계 모이어티에 사용되는 기능기의 예시에는 친핵성 기와 반응하기 위한 친전자체, 그리고 친전자성 기와 반응하기 위한 친핵체가 내포되지만, 이에 국한되지 않는다. 특정 구체예들에서, 이중기능성 연계 모이어티는 아미노, 히드록실, 카르복실산, 티올, 알킬, 알케닐, 그리고 알키닐에서 선택된 하나 또는 그 이상의 기를 포함한다.
콘쥬게이트 링커의 예시에는 피롤리딘, 8-아미노-3,6-디옥사옥타논산 (ADO), 숙시니미딜 4-(N-말레이미도메틸) 시클로헥산-1-카르복실레이트 (SMCC) 및 6-아미노헥사논산 (AHEX 또는 AHA)이 내포되지만, 이에 국한되지 않는다. 기타 콘쥬게이트 링커에는 치환된 또는 치환안된 C1-C10 알킬, 치환된 또는 치환안된 C2-C10 알케닐 또는 치환된 또는 치환안된 C2-C10 알키닐이 내포되지만, 이에 국한되지 않으며, 이때 선호되는 치환기의 목록에는 히드록실, 아미노, 알콕시, 카르복시, 벤질, 페닐, 니트로, 티올, 티오알콕시, 할로겐, 알킬, 아릴, 알케닐 및 알키닐이 내포되지만, 이에 국한되지 않는다.
특정 구체예들에서, 콘쥬게이트 링커는 1-10개의 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 2-5개의 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 정확하게 3개의 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 TCA 모티프를 포함한다. 특정 구체예들에서, 이러한 링커-뉴클레오시드는 변형된 뉴클레오시드이다. 특정 구체예들에서, 이러한 링커-뉴클레오시드는 변형된 당 모이어티를 포함한다. 특정 구체예들에서, 링커-뉴클레오시드는 변형안된 것이다. 특정 구체예들에서, 링커-뉴클레오시드는 퓨린, 치환된 퓨린, 피리미딘 또는 치환된 피리미딘으로부터 선택된 임의선택적으로 보호된 헤테로사이클 염기를 포함한다. 특정 구체예들에서, 절단가능한 모이어티는 우라실, 티민, 시토신, 4-N-벤조일시토신, 5-메틸 시토신, 4-N-벤조일-5-메틸 시토신, 아데닌, 6-N-벤조일아데닌, 구아닌 및 2-N-이소부티릴구아닌에서 선택된 뉴클레오시드이다. 링커-뉴클레오시드의 경우, 올리고머 화합물이 표적 조직에 도착된 후, 이 올리고머 화합물로부터 절단되는 것이 일반적으로 바람직하다. 따라서, 링커-뉴클레오시드는 전형적으로 서로 연계되고, 절단가능한 결합을 통하여 해당 올리고머 화합물의 나머지 부분과도 연계되어 있다. 특정 구체예들에서, 이러한 절단가능한 결합은 포스포디에스테르 결합이다.
본원에서, 링커-뉴클레오시드는 상기 올리고뉴클레오티드의 일부분으로 간주되지 않는다. 따라서, 올리고머 화합물은 명시된 숫자 또는 범위의 연계된 뉴클레오시드로 구성된 올리고뉴클레오티드를 포함하거나, 및/또는 기준 핵산에 대해 명시된 상보성의 올리고뉴클레오티드를 포함하고, 올리고머 화합물은 링커-뉴클레오시드를 포함하는 콘쥬게이트 링커를 포함하는 콘쥬게이트 기를 또한 포함하는 구체예에서, 이들 링커-뉴클레오시드는 해당 올리고뉴클레오티드의 길이에 카운트되지 않고, 그리고 기준 핵산에 대해 해당 올리고뉴클레오티드의 상보성 퍼센트 결정에도 이용되지 않는다. 예를 들면, 올리고머 화합물은 (1) 8-30개의 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드, 그리고 (2) 상기 변형된 올리고뉴클레오티드의 뉴클레오시드에 연접한 1-10개의 링커-뉴클레오시드를 포함하는 콘쥬게이트 기를 포함할 수 있다. 이러한 올리고머 화합물에서 연접한 연계된 뉴클레오시드의 총 갯수는 30을 넘는다. 대안으로, 올리고머 화합물은 콘쥬게이트 기 없이, 8-30개의 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함할 수 있다. 이러한 올리고머 화합물에서 연접한 연계된 뉴클레오시드의 총 갯수는 30을 넘지 않는다. 달리 명시되지 않는 한, 콘쥬게이트 링커는 10개를 넘지 않는 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 5개를 넘지 않는 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 3개를 넘지 않는 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 2개를 넘지 않는 링커-뉴클레오시드를 포함한다. 특정 구체예들에서, 콘쥬게이트 링커는 1개를 넘지 않는 링커-뉴클레오시드를 포함한다.
특정 구체예들에서, 콘쥬게이트 기의 경우 해당 올리고뉴클레오티드로부터 절단되는 것이 바람직하다. 예를 들면, 특정 상황에서, 특정 콘쥬게이트 모이어티를 포함하는 올리고머 화합물들은 특정 세포 유형에 의한 취입에 더 우수하지만, 그러나 일단 상기 올리고머 화합물가 취입된 후, 콘쥬게이트안된, 또는 부모 올리고뉴클레오티드를 방출시키도록 하기 위해 상기 콘쥬게이트 기가 절단되는 것이 바람직하다. 따라서, 특정 콘쥬게이트 링커는 하나 또는 그 이상의 절단가능한 모이어티를 포함할 수 있다. 특정 구체예들에서, 절단가능한 모이어티는 절단가능한 결합이다. 특정 구체예들에서, 절단가능한 모이어티는 적어도 하나의 절단가능한 결합를 포함하는 원자들의 기다. 특정 구체예들에서, 절단가능한 모이어티는 1개, 2개, 3개, 4개 또는 4개 이상의 절단가능한 결합을 갖는 원자들의 기를 포함한다. 특정 구체예들에서, 절단가능한 모이어티는 세포 또는 하위세포 격실, 이를 테면, 리소좀 내에서 선택적으로 절단된다. 특정 구체예들에서, 절단가능한 모이어티는 내생성 효소, 이를 테면, 뉴클레아제에 의해 선택적으로 절단된다.
특정 구체예들에서, 절단가능한 결합은 아미드, 에스테르, 에테르, 포스포디에스테르의 하나의 에스테르 또는 두 에스테르, 포스페이트 에스테르, 카르바메이트, 또는 디술파이드에서 선택된다. 특정 구체예들에서, 절단가능한 결합은 포스포디에스테르의 하나의 에스테르 또는 두 에스테르이다. 특정 구체예들에서, 절단가능한 모이어티는 포스페이트 또는 포스포디에스테르를 포함한다. 특정 구체예들에서, 상기 절단가능한 모이어티는 올리고뉴클레오티드와 콘쥬게이트 모이어티 사이 또는 콘쥬게이트 기 사이의 포스페이트 또는 포스포디에스테르 링키지이다.
특정 구체예들에서, 절단가능한 모이어티는 하나 또는 그 이상의 링커-뉴클레오시드를 포함하거나, 또는 이로 구성된다. 이러한 특정 구체예들에서, 상기 하나 또는 그 이상의 링커-뉴클레오시드는 서로 연계되거나, 및/또는 절단가능한 결합을 통하여 해당 올리고머 화합물의 나머지 부분과도 연계되어 있다. 특정 구체예들에서, 이러한 절단가능한 결합은 변형안된 포스포디에스테르 결합이다. 특정 구체예들에서, 절단가능한 모이어티는 포스포디에스테르 뉴클레오시드간 링키지에 의해 올리고뉴클레오티드의 3' 또는 5'-말단 뉴클레오시드에 부착되고, 그리고 포스페이트 또는 포스포로티오에이트 링키지에 의해 콘쥬게이트 링커 또는 콘쥬게이트 모이어티의 나머지에 공유적으로 부착된 2'-데옥시뉴클레오시드이다. 이러한 특정 구체예들에서, 상기 절단가능한 모이어티는 2'-데옥시아데노신이다.
3.
세포-표적화 모이어티
특정 구체예들에서, 콘쥬게이트 기는 세포-표적화 모이어티를 포함한다 특정 구체예들에서, 콘쥬게이트 기는 다음 일반식을 갖고:
이때 n은 1 ~ 약 3이며, n이 1인 경우 m은 0이고, n이 2 또는 그 이상인 경우 m은 1이며, j는 1 또는 0이며, 그리고 k는 1 또는 0이다.
특정 구체예들에서, n은 1이며, j는 1이고, 그리고 k는 0이다. 특정 구체예들에서, n은 1이며, j는 0이고, 그리고 k는 1이다. 특정 구체예들에서, n은 1이며, j는 1이고, 그리고 k는 1이다. 특정 구체예들에서, n은 2이며, j는 1이고, 그리고 k는 0이다. 특정 구체예들에서, n은 2이며, j는 0이고, 그리고 k는 1이다. 특정 구체예들에서, n은 2이며, j는 1이고, 그리고 k는 1이다. 특정 구체예들에서, n은 3이며, j는 1이고, 그리고 k는 0이다. 특정 구체예들에서, n은 3이며, j는 0이고, 그리고 k는 1이다. 특정 구체예들에서, n은 3이며, j는 1이고, 그리고 k는 1이다.
특정 구체예들에서, 콘쥬게이트 기는 적어도 하나의 테터링된(tethered) 리간드를 갖는 세포-표적화 모이어티를 포함한다. 특정 구체예들에서, 세포-표적화 모이어티는 분기화(branching) 기에 공유적으로 부착된 2개의 테터링된 리간드를 포함한다. 특정 구체예들에서, 세포-표적화 모이어티는 분기화 기에 공유적으로 부착된 3개의 테터링된 리간드를 포함한다.
B.
특정 말단 기
특정 구체예들에서, 올리고머 화합물들은 하나 또는 그 이상의 말단 기를 포함한다. 이러한 특정 구체예들에서, 올리고머 화합물들은 안정화된 5'-포스페이트을 포함한다. 안정화된 5'-포스페이트에는 5'-비닐포스포네이트를 비롯한, 그러나 이에 국한되지 않는, 5'-포스포네이트가 내포되나, 이에 국한되지 않는다. 특정 구체예들에서, 말단 기는 하나 또는 그 이상의 무염기 뉴클레오시드 및/또는 역전된(inverted) 뉴클레오시드를 포함한다. 특정 구체예들에서, 말단 기는 하나 또는 그 이상의 2'-연계된 뉴클레오시드를 포함한다. 이러한 특정 구체예들에서, 상기 2'-연계된 뉴클레오시드는 무염기(abasic) 뉴클레오시드이다.
III.
올리고머 듀플렉스
특정 구체예들에서, 본원에 기술된 올리고머 화합물들은 표적 핵산의 핵염기 서열에 상보성인 핵염기 서열을 갖는 올리고뉴클레오티드를 포함한다. 특정 구체예들에서, 올리고머 화합물은 제 2 올리고머 화합물과 쌍을 형성하여, 올리고머 듀플렉스가 형성된다. 이러한 올리고머 듀플렉스는 표적 핵산에 상보성 부분을 갖는 제 1 올리고머 화합물, 그리고 상기 제 1 올리고머 화합물에 상보성인 부분을 갖는 제 2 올리고머 화합물을 포함한다. 특정 구체예들에서, 올리고머 듀플렉스의 제 1 올리고머 화합물은 (1) 변형된 또는 변형안된 올리고뉴클레오티드 및 임의선택적으로 콘쥬게이트 기, 그리고 (2) 제 2 변형된 또는 변형안된 올리고뉴클레오티드 및 임의선택적으로 콘쥬게이트 기를 포함하거나, 또는 이로 구성된다. 올리고머 듀플렉스중 하나의 올리고머 화합물 또는 모든 올리고머 화합물은 콘쥬게이트 기를 포함할 수 있다. 올리고머 듀플렉스의 각 올리고머 화합물의 올리고뉴클레오티드에는 비-상보성 오버행(overhanging) 뉴클레오시드가 내포될 수 있다.
IV.
안티센스 활성
특정 구체예들에서, 올리고머 화합물들과 올리고머 듀플렉스는 표적 핵산에 혼성화될 수 있고, 이로써 적어도 하나의 안티센스 활성이 초래되며; 이러한 올리고머 화합물들과 올리고머 듀플렉스는 안티센스 화합물들이다. 특정 구체예들에서, 안티센스 화합물들이 표준 세포 검정에서 표적 핵산의 양 또는 활성을 25% 또는 그 이상으로 감소시킬 때, 이 화합물들은 안티센스 활성을 갖는다. 특정 구체예들에서, 안티센스 화합물들은 하나 또는 그 이상의 표적 핵산에 선택적으로 영향을 준다. 이러한 안티센스 화합물들은 하나 또는 그 이상의 표적 핵산에 혼성화되는 핵염기 서열을 포함하고, 이로써 하나 또는 그 이상의 원하는 안티센스 활성이 초래되며, 유의미적인 원하지 않는 안티센스 활성을 초래하는 하나 또는 그 이상의 비-표적 핵산에 혼성화되지 않거나, 또는 하나 또는 그 이상의 비-표적 핵산에 혼성화되지 않는다.
특정 안티센스 활성에서, 안티센스 화합물이 표적 핵산에 혼성화되면 해당 표적 핵산을 분할시키는 단백질을 운집하게 된다. 예를 들면, 특정 안티센스 화합물들은 해당 표적 핵산의 Rnase H 매개된 분할을 초래한다. RNase H는 RNA:DNA 듀플렉스에서 RNA 가닥을 분할시키는 세포성 엔도뉴클레아제이다. 이러한 RNA:DNA 듀플렉스에서 DNA는 변형안된 DNA일 필요는 없다. 특정 구체예들에서, RNase H 활성을 유도하지 위해 충분히 "DNA-유사"한 안티센스 화합물들이 본원에 기술된다. 특정 구체예들에서, 갭머의 갭에서 하나 또는 그 이상의 비-DNA-유사 뉴클레오시드가 용인된다.
특정 안티센스 활성에서, 안티센스 화합물 또는 안티센스 화합물의 부분은 RNA-유도된 침묵 복합체 (RISC)로 로딩되고, 결국 해당 표적 핵산의 분할이 초래된다. 예를 들면, 특정 안티센스 화합물들은 Argonaute에 의해 해당 표적 핵산의 분할을 초래한다. RISC에 로딩된 안티센스 화합물은 RNAi 화합물들이다. RNAi 화합물들은 이중-가닥으로 되거나 (siRNA) 또는 단일-가닥으로 된 (ssRNA) 것일 수 있다.
특정 구체예들에서, 안티센스 화합물이 표적 핵산에 혼성화되어도 해당 표적 핵산을 분할시키는 단백질을 운집시키지 않는다. 특정 구체예들에서, 상기 안티센스 화합물이 해당 표적 핵산에 혼성화되면 해당 표적 핵산의 스플라이싱 변경이 초래된다. 특정 구체예들에서, 상기 안티센스 화합물이 해당 표적 핵산에 혼성화되면 해당 표적 핵산과 단백질 또는 기타 핵산간의 결합 상호작용의 저해가 초래된다. 특정 구체예들에서, 상기 안티센스 화합물이 해당 표적 핵산에 혼성화되면 해당 표적 핵산의 해독 변경이 초래된다.
안티센스 활성은 직접적으로 또는 간접적으로 관찰될 수 있다. 특정 구체예들에서, 안티센스 활성의 관찰 또는 검출은 표적 핵산 또는 이러한 표적 핵산에 의해 인코딩되는 단백질의 양에서 변화의 관찰 또는 검출, 세포 또는 대상체의 핵산 또는 단백질 및/또는 표현형의 스플라이스 변이체 비율에서 변화의 관찰 또는 검출과 관련된다.
V.
특정 표적 핵산
특정 구체예들에서, 올리고머 화합물들은 표적 핵산에 상보성인 부분을 포함하는 올리고뉴클레오티드를 포함하거나, 또는 이로 구성된다. 특정 구체예들에서, 상기 표적 핵산은 내생적 RNA 분자이다. 특정 구체예들에서, 상기 표적 핵산은 단백질을 인코드한다. 이러한 특정 구체예들에서, 상기 표적 핵산은 성숙 mRNA 및 인트론, 엑손 및 비-해독 영역을 포함하는 pre-mRNA로부터 선택된다. 특정 구체예들에서, 상기 표적 핵산은 성숙 mRNA이다. 특정 구체예들에서, 상기 표적 핵산은 pre-mRNA이다. 이러한 특정 구체예들에서, 상기 표적 영역은 인트론 내에 전적으로 존재한다. 특정 구체예들에서, 상기 표적 영역은 인트론/엑손 졍션까지 이어진다. 특정 구체예들에서, 상기 표적 영역은 인트론 내 적어도 50%가 있다.
A.
표적 핵산에 대해 상보성/미스매치
활성의 제거 없이, 미스매치 염기의 도입이 가능하다. 예를 들면, Gautschi et al (J. Natl. Cancer Inst. 93:463-471, March 2001)는 bcl-2 mRNA에 대해 100% 상보성을 갖고, bcl-xL mRNA에 대해 3개의 미스매치를 갖는 올리고뉴클레오티드가 시험관내 및 생체내에서 bcl-2 및 bcl-xL 둘 모두의 발현을 감소시키는 능력을 입증하였다. 더욱이, 이 올리고뉴클레오티드는 생체내 강력한 항-종양 활성을 실증하였다. Maher and Dolnick (Nuc. Acid. Res. 16:3341-3358, 1988)는 토끼 망상적혈구 분석에서 인간 DHFR의 해독을 저지하는 능력에 대해 차례로 직렬(tandem) 14개 핵염기 올리고뉴클레오티드와 이들 2개 또는 3개의 직렬 올리고뉴클레오티드 서열로 구성된 28개 및 42개 핵염기 올리고뉴클레오티드 시리즈를 테스트했다. 14개의 핵염기 올리고뉴클레오티드 세 가지 단독은 28개 또는 42개 핵염기 올리고뉴클레오티드보다 더 적당한 수준으로, 해독을 억제하였다.
특정 구체예들에서, 올리고뉴클레오티드는 올리고뉴클레오티드의 전체 길이에 걸쳐 표적 핵산에 상보적이다. 특정 구체예들에서, 올리고뉴클레오티드는 상기 표적 핵산에 대해 99%, 95%, 90%, 85%, 또는 80% 상보성이다. 특정 구체예들에서, 올리고뉴클레오티드는 이 올리고뉴클레오티드의 전체 길이에 걸쳐 표적 핵산에 적어도 80% 상보성이며, 그리고 표적 핵산에 대해 100% 또는 완전한 상보성 부분을 포함한다. 특정 구체예들에서, 상기 온전한(full) 상보성 부분의 길이는 6개, 7개, 8개, 9개, 10개, 11개, 12개, 13개, 14개, 15개, 16개, 17개, 18개, 19개, 20개, 21개, 22개, 23개, 또는 24개의 핵염기이다.
특정 구체예들에서, 올리고뉴클레오티드는 표적 핵산에 대해 하나 또는 그 이상의 미스매치된 핵염기를 포함한다. 특정 구체예들에서, 표적에 대항하는 안티센스 활성은 이러한 미스매치에 의해 감소되지만, 그러나 비-표적에 대항하는 활성이 더 많은 양으로 감소된다. 따라서, 특정 구체예들에서, 상기 올리고뉴클레오티드의 선택성이 개선된다. 특정 구체예들에서, 상기 미스매치는 갭머 모티프를 갖는 올리고뉴클레오티드 내에 특이적으로 위치한다. 특정 구체예들에서, 상기 미스매치는 갭 영역의 5'-단부로부터 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 또는 11에 위치한다. 특정 구체예들에서, 상기 미스매치는 5' 윙 영역 또는 3' 윙 영역의 5'-단부로부터 1, 2, 3, 4, 5, 또는 6에 위치한다.
B.
ATXN1
특정 구체예들에서, 올리고머 화합물들은 표적 핵산에 상보성인 올리고뉴클레오티드를 포함하거나, 또는 이로 구성되며, 이때 상기 표적 핵산은 ATXN1 핵산이다. 특정 구체예들에서, ATXN1 핵산은 서열 식별 번호: 1 (GENBANK 수탁 번호 NM_000332.3), 서열 식별 번호: 2 (뉴클레오티드 16296001 ~ 16764000로부터 절두된 GENBANK 수탁 번호 NC_000006.12의 보체), 서열 식별 번호: 3 (GENBANK 수탁 번호 NM_001128164.1), 서열 식별 번호: 4 (GENBANK 수탁 번호 BC011026.1), 서열 식별 번호: 5 (GENBANK 수탁 번호 BC029401.1), 또는 서열 식별 번호: 6 (GENBANK 수탁 번호 BC047894.1)에서 제시된 서열을 갖는다.
특정 구체예들에서, 서열 식별 번호: 1-6중 임의의 것에 상보성인 올리고머 화합물을 세포에 접촉시키면 이 세포에서 ATXN1 RNA의 양이 감소된다. 특정 구체예들에서, 서열 식별 번호: 1-6중 임의의 것에 상보성인 올리고머 화합물을 세포에 접촉시키면 이 세포에서 ATXN1의 양이 감소된다. 특정 구체예들에서, 상기 세포는 시험관내에 있다. 특정 구체예들에서, 상기 세포는 대상체내에 있다. 특정 구체예들에서, 상기 올리고머 화합물은 변형된 올리고뉴클레오티드로 구성된다. 특정 구체예들에서, 서열 식별 번호: 1-6중 임의의 것에 상보성인 올리고머 화합물을 대상체의 세포에 접촉시키면 신경퇴행성 질환의 하나 또는 그 이상의 증상 또는 특징이 개선된다. 특정 구체예들에서, 상기 신경퇴행성 질환은 SCA1이다. 특정 구체예들에서, 이러한 증상 및 특징은 보행 및 사지 운동실조, 인지 장애, 말하기 및 삼키기 어려움, 자기 공명 영상(MRI)에서 소뇌 및 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 감지된 소뇌 및 뇌간의 신경화학적 이상 및 증상 발병 후 10-15년 이내에 사망에서 선택된다.
특정 구체예들에서, 표준 세포 검정에 따라 투여될 때, 서열 식별 번호: 1-6중 임의의 서열에 대해 상보성인 올리고머 화합물은 시험관내 에서 ATXN1 RNA의 검출가능한 양을 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90% 줄일 수 있다. 특정 구체예들에서, 표준 세포 검정에 따라 투여될 때, 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6에 대해 상보성인 올리고머 화합물은 시험관내 에서 ATXN1의 양을 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90% 감소시킬 수 있다. 특정 구체예들에서, 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6에 대해 상보성인 올리고머 화합물은 대상체의 CSF에서 ATXN1 RNA의 검출가능한 양을 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90% 줄일 수 있다. 특정 구체예들에서, 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6에 대해 상보성인 올리고머 화합물은 대상체의 CSF에서 ATXN1의 검출가능한 양을 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90% 감소시킬 수 있다.
C.
특정 조직에서 특정 표적 핵산
특정 구체예들에서, 올리고머 화합물들은 표적 핵산에 상보성인 부분을 포함하는 올리고뉴클레오티드를 포함하거나, 또는 이로 구성되며, 이때 상기 표적 핵산은 약학적으로 관련 조직에서 발현된다. 특정 구체예들에서, 상기 약학적으로 관련 조직은 중추신경계를 포함하는 세포 및 조직이다. 이러한 조직에는 피질, 소뇌, 그리고 뇌간이 내포된다.
VI.
특정 약제학적 조성물들
특정 구체예들에서, 하나 또는 그 이상의 올리고머 화합물을 포함하는 약제학적 조성물이 본원에 기술된다. 특정 구체예들에서, 상기 하나 또는 그 이상의 올리고머 화합물은 변형된 각 올리고뉴클레오티드로 구성된다. 특정 구체예들에서, 상기 약제학적 조성물은 약제학적으로 수용가능한 희석제 또는 담체를 포함한다. 특정 구체예들에서, 약제학적 조성물은 멸균 염수 용액과 하나 또는 그 이상의 올리고머 화합물을 포함하거나, 또는 이로 구성된다. 특정 구체예들에서, 상기 멸균 염수는 약제학적 등급의 염수다. 특정 구체예들에서, 약제학적 조성물은 하나 또는 그 이상의 올리고머 화합물 및 멸균수를 포함하거나, 또는 이로 구성된다. 특정 구체예들에서, 상기 멸균수는 약제학적 등급의 물이다. 특정 구체예들에서, 약제학적 조성물은 하나 또는 그 이상의 올리고머 화합물과 포스페이트-완충된 염수 (PBS)를 포함하거나, 또는 이로 구성된다. 특정 구체예들에서, 상기 멸균 PBS는 약제학적 등급의 PBS이다. 특정 구체예들에서, 약제학적 조성물은 하나 또는 그 이상의 올리고머 화합물과 인공 뇌척수액을 포함하거나, 또는 이로 구성된다. 특정 구체예들에서, 상기 인공 뇌척수액은 약제학적 등급이다.
특정 구체예들에서, 약제학적 조성물은 변형된 올리고뉴클레오티드 및 인공 뇌척수액을 포함한다. 특정 구체예들에서, 약제학적 조성물은 변형된 올리고뉴클레오티드 및 인공 뇌척수액으로 구성된다. 특정 구체예들에서, 약제학적 조성물은 변형된 올리고뉴클레오티드 및 인공 뇌척수액으로 필수적으로 구성된다. 특정 구체예들에서, 상기 인공 뇌척수액은 약제학적 등급이다.
특정 구체예들에서, 약제학적 조성물들은 하나 또는 그 이상의 올리고머 화합물과 하나 또는 그 이상의 부형제를 포함한다. 특정 구체예들에서, 부형제는 물, 염 용액, 알코올, 폴리에틸렌 글리콜, 젤라틴, 락토즈, 아밀라아제, 마그네슘 스테아레이트, 활석, 규산, 점성 파라핀, 히드록시메틸셀룰로오스 및 폴리비닐피롤리돈으로부터 선택된다.
특정 구체예들에서, 올리고머 화합물들은 약제학적 조성물 또는 제형의 제조를 위해, 약제학적으로 허용되는 활성 및/또는 불활성 물질과 혼합될 수 있다. 약제학적 조성물의 제형화를 위한 조성물 및 방법은 투여 경로, 질환의 정도, 또는 투여되는 용량을 포함하나, 이에 국한되지 않는 다수의 기준에 의존한다.
특정 구체예들에서, 올리고머 화합물을 포함하는 약제학적 조성물들에는 이들 올리고머 화합물의 임의의 약제학적으로 수용가능한 염, 상기 올리고머 화합물의 에스테르, 또는 이러한 에스테르의 염이 포괄된다. 특정 구체예들에서, 하나 또는 그 이상의 올리고뉴클레오티드를 포함하는 올리고머 화합물을 포함하는 약제학적 조성물들을 대상체(인간을 비롯한)에게 투여할 때, 생물학적으로 활성인 대사산물 또는 이의 잔기를 (직접 또는 간접적으로) 제공할 수 있다. 따라서, 예를 들면, 본 명세서는 또한 올리고머 화합물들의 약제학적으로 수용가능한 염, 프로드럭, 이러한 프로드럭의 약제학적으로 수용가능한 염, 그리고 기타 생물학적 등가물에 관한 것이다. 적합한 약제학적으로 수용가능한 염에는 나트륨 염 및 칼륨 염이 내포되나, 이에 국한되지 않는다. 특정 구체예들에서, 프로드럭은 올리고뉴클레오티드에 부착된 하나 또는 그 이상의 콘쥬게이트 기를 포함하며, 이때 상기 콘쥬게이트 기는 체내에서 내생적 뉴클레아제에 의해 분할된다.
지질 모이어티가 핵산 요법에서 다양한 방법에 이용되었다. 이러한 특정 방법들에서, 핵산, 이를 테면, 올리고머 화합물은 양이온성 지질 및 중성 지질의 혼합물로 만들어진 사전-형성된 리포좀 또는 리포플렉스로 도입된다. 특정 방법들에서, 모노- 또는 폴리-양이온성 지질과의 DNA 복합체들은 중성 지질의 존재없이 형성된다. 특정 구체예들에서, 지질 모이어티는 약제학적 제제의 특정 세포 또는 조직으로의 분포를 증가시키기 위해 선택된다. 특정 구체예들에서, 지질 모이어티는 약제학적 제제의 지방 조직으로의 분포를 증가시키기 위해 선택된다. 특정 구체예들에서, 지질 모이어티는 약제학적 제제의 근육 조직으로의 분포를 증가시키기 위해 선택된다.
특정 구체예들에서, 약제학적 조성물들은 전달 시스템을 포함한다. 전달 시스템들의 예들에는, 리포좀 및 에멀젼이 내포되나, 이에 국한되는 것은 아니다. 특정 전달 시스템들은 소수성 화합물들을 포함하는 시스템들을 비롯하여, 특정 제약학적 조성물들을 제조함에 유용하다. 특정 구체예들에서, 특정 유기 용매들, 가령, 다이메틸설폭사이드가 사용된다.
특정 구체예에서, 본원에서 제공된 올리고머 화합물을 포함하는 하나 또는 그 이상의 약제학적 작용제를 운반하기 위해 설계된 하나 또는 그 이상의 조직-특이적 전달 분자들을 포함한다. 예를 들면, 특정 구체예에서, 약제학적 조성물에는 조직-특이적 항체로 코팅된 리포좀이 내포된다..
특정 구체예들에서, 약제학적 조성물은 공-용매 시스템을 포함한다. 이러한 특정 공-용매 시스템은 예를 들면, 벤질 알코올, 비-극성 계면활성제, 수-혼화성 유기 중합체 및 수용성 상(phase)을 포함한다. 특정 구체예들에서, 소수성 화합물에 이러한 공-용매 시스템이 이용된다. 이러한 공-용매 시스템은 VPD 공-용매 시스템이며, 이는 3% w/v 벤질 알코올, 8% w/v 비-극성 계면활성제 Polysorbate 80™ 및 65% w/v 폴리에틸렌 글리콜 300을 포함하는 순수 에탄올 용액이다. 이러한 공용매 시스템의 비율은 용해도 및 독성 특성을 크게 변경하지 않으면서, 상당히 가변적일 수 있다. 더욱이, 공-용매 성분들의 실체는 가변적일 수 있다: 예를 들면, Polysorbate 80™를 대신하여 다른 계면활성제가 이용될 수 있으며; 폴리에틸렌 글리콜의 분획 크기가 가변적일 수 있고; 폴리에틸렌 글리콜을 대신하여 다른 생물적합성 폴리머, 가령, 폴리비닐 피롤리돈이 이용될 수 있으며; 그리고 기타 당 또는 폴리사카라이드가 덱스트로스를 대체할 수 있다.
특정 구체예들에서, 경구 투여용으로 약제학적 조성물이 제조된다. 특정 구체예들에서, 볼 투여용으로 약제학적 조성물이 제조된다. 특정 구체예들에서, 약제학적 조성물은 주사(예를 들어, 정맥내, 피하, 근육내, 척추강내(IT), 뇌실내(ICV) 등등)에 의한 투여용으로 제조된다. 이러한 특정 구체예들에서, 약제학적 조성물은 담체를 포함하고, 수성 용액, 이를 테면, 물, 또는 행크스(Hanks) 용액, 링거(Ringer) 용액 또는 생리 식염수 완충제와 같은 생리학적으로 적합한 완충제에서 제형화된다. 특정 구체예들에서, 기타 성분들이 내포된다 (가령, 용해도를 돕거나 또는 보존제 역할을 하는 성분들). 특정 구체예들에서, 주사가능한 현탁액은 적절한 액체 담체, 현탁화제 및 이와 유사한 것들을 사용하여 제조된다. 특정한 주사용 약제학적 조성물들은 단위 투약형, 예컨대, 앰플 또는 다회-투여 용기로 제공된다. 특정한 주사용 약제학적 조성물들은 유성 비히클 또는 수성 비히클에서의 현탁액, 용액 또는 에멀젼이며, 제형화 제제, 가령, 현탁화제, 안정화제 및/또는 분산제를 함유할 수 있다. 주사용 약제학적 조성물에 사용하기에 적합한 특정 용매들에는 친유성 용매 및 지방 오일, 가령, 참기름, 합성 지방산 에스테르, 가령, 에틸 올레이트 또는 트라이글리세라이드, 및 리포좀이 내포되나, 이에 국한되는 것은 아니다.
VII.
특정 조성물들
1.
화합물 번호 994509
특정 구체예들에서, 화합물 번호 994509는 (5'에서 3' 방향으로) GCACGGTATTAGTGTCTTCA (서열 식별 번호: 126)의 서열을 갖는 5-10-5 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 16-20 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-15 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 2 ~ 3, 3 ~ 4, 4 ~ 5, 16 ~ 17, 그리고 17 ~ 18 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 14 ~ 15, 15 ~ 16, 18 ~ 19, 그리고 19 ~ 20 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 994509는 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: Ges mCeo Aeo mCeo Ges Gds Tds Ads Tds Tds Ads Gds Tds Gds Tds mCeo Teo Tes mCes Ae (서열 식별 번호: 126), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 994509는 다음의 화학 구조로 나타낸다:
구조 1. 화합물 번호 994509
특정 구체예들에서, 화합물 번호 994509의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 2. 화합물 번호 994509의 나트륨염
2.
화합물 번호 1040500
특정 구체예들에서, 화합물 번호 1040500는 (5'에서 3' 방향으로) GCTTCTCAAATCAGGTGTAC (서열 식별 번호: 1045)의 서열을 갖는 5-10-5 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 16-20 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-15 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 2 ~ 3, 3 ~ 4, 4 ~ 5, 16 ~ 17, 그리고 17 ~ 18 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 14 ~ 15, 15 ~ 16, 18 ~ 19, 그리고 19 ~ 20 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 1040500은 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: Ges mCeo Teo Teo mCes Tds mCds Ads Ads Ads Tds mCds Ads Gds Gds Teo Geo Tes Aes mCe (서열 식별 번호: 1045), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 1040500은 다음의 화학 구조로 나타낸다:
구조 3. 화합물 번호 1040500
특정 구체예들에서, 화합물 번호 1040500의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 4. 화합물 번호 1040500의 나트륨염
3.
화합물 번호 1041927
특정 구체예들에서, 화합물 번호 1041927는 (5'에서 3' 방향으로) GCCTTTATAACTTTTCTTTC (서열 식별 번호: 2552)의 서열을 갖는 5-10-5 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 16-20 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-15 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 2 ~ 3, 3 ~ 4, 4 ~ 5, 16 ~ 17, 그리고 17 ~ 18 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 14 ~ 15, 15 ~ 16, 18 ~ 19, 그리고 19 ~ 20 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 1041927은 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: Ges mCeo mCeo Teo Tes Tds Ads Tds Ads Ads mCds Tds Tds Tds Tds mCeo Teo Tes Tes mCe (서열 식별 번호: 2552), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 1041927은 다음의 화학 구조로 나타낸다:
구조 5. 화합물 번호 1041927
특정 구체예들에서, 화합물 번호 1041927의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 6. 화합물 번호 1041927의 나트륨염
4.
화합물 번호 1055001
특정 구체예들에서, 화합물 번호 1055001는 (5'에서 3' 방향으로) TTCAGTTTAGTTGCAGCCAT (서열 식별 번호: 3190)의 서열을 갖는 5-10-5 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 16-20 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-15 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 2 ~ 3, 3 ~ 4, 4 ~ 5, 16 ~ 17, 그리고 17 ~ 18 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 14 ~ 15, 15 ~ 16, 18 ~ 19, 그리고 19 ~ 20 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 1055001은 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: Tes Teo mCeo Aeo Ges Tds Tds Tds Ads Gds Tds Tds Gds mCds Ads Geo mCeo mCes Aes Te (서열 식별 번호: 3190), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 1055001은 다음의 화학 구조로 나타낸다:
구조 7. 화합물 번호 1055001
특정 구체예들에서, 화합물 번호 1055001의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 8. 화합물 번호 1055001의 나트륨염
5.
화합물 번호 1371311
특정 구체예들에서, 화합물 번호 1371311는 (5'에서 3' 방향으로) CCCGTATTCCTCTTACCATC (서열 식별 번호: 3590)의 서열을 갖는 5-10-5 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 16-20 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-15 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 2 ~ 3, 3 ~ 4, 4 ~ 5, 16 ~ 17, 그리고 17 ~ 18 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 14 ~ 15, 15 ~ 16, 18 ~ 19, 그리고 19 ~ 20 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 1371311은 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: mCes mCeo mCeo Geo Tes Ads Tds Tds mCds mCds Tds mCds Tds Tds Ads mCeo mCeo Aes Tes mCe (서열 식별 번호: 3590), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 1371311은 다음의 화학 구조로 나타낸다:
구조 9. 화합물 번호 1371311
특정 구체예들에서, 화합물 번호 1371311의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 10. 화합물 번호 1371311의 나트륨염
6.
화합물 번호 1385293
특정 구체예들에서, 화합물 번호 1385293은 (5'에서 3' 방향으로) TCAGTTTAGTTGCAGCC (서열 식별 번호: 3638)의 서열을 갖는 5-8-4 MOE 갭머로 특징화되며, 이때 뉴클레오시드 1-5 및 14-17 (5'에서 3' 방향으로) 각각은 2'-MOE 뉴클레오시드이며, 뉴클레오시드 6-13 각각은 2'-β-D-데옥시뉴클레오시드이며, 이때 뉴클레오시드 4 ~ 5 및 14 ~ 15 사이의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지이며, 뉴클레오시드 1 ~ 2, 3 ~ 4, 5 ~ 6, 6 ~ 7, 7 ~ 8, 8 ~ 9, 9 ~ 10, 10 ~ 11, 11 ~ 12, 12 ~ 13, 13 ~ 14, 15 ~ 16, 그리고 16 ~ 17 사이의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지이며, 이때 각 시토신은 5-메틸 시토신이다.
특정 구체예들에서, 화합물 번호 1385293은 다음의 화학적 표기 (5'에서 3' 방향으로)로 나타낸다: Tes mCes Aes Geo Tes Tds Tds Ads Gds Tds Tds Gds mCds Aeo Ges mCes mCe (서열 식별 번호: 3638), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
특정 구체예들에서, 화합물 번호 1385293은 다음의 화학 구조로 나타낸다:
구조 11. 화합물 번호 1385293
특정 구체예들에서, 화합물 번호 1385293의 나트륨염은 다음의 화학 구조로 나타낸다:
구조 12. 화합물 번호 1385293의 나트륨염
VIII.
특정 핫스팟 영역
특정 구체예들에서, 하기에 명시된 범위의 핵염기는 ATXN1 핵산의 핫스팟(hotspot) 영역을 포함한다. 특정 구체예들에서, ATXN1 핵산의 핫스팟 영역내에 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 75% 이상 줄였다. 특정 구체예들에서, ATXN1 핵산의 핫스팟 영역내에 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내 검정에서 ATXN1 RNA를 평균 24% 또는 그 이상으로 감소시켰다. 특정 구체예들에서, ATXN1 핵산의 핫스팟 영역내에 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내 검정에서 ATXN1 RNA를 평균 45% 또는 그 이상으로 감소시켰다.
1.
서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 핵염기 459725-459805
특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 핵염기 459725-459805는 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805 내에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 17개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 혼합형 윙 갭머이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 5-8-4 MOE 갭머이거나 또는 5-8-4 혼합형 MOE/cEt 갭머이다. 특정 구체예들에서, 상기 혼합형 윙 갭머는 5'에서 3' 방향의 순서로 당 모티프: eeeeeddddddddkkee를 갖고; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 특정 구체예들에서, 상기 갭머는 갭 안에 2'-치환된 뉴클레오시드를 포함한다. 특정 구체예들에서, 상기 2'-치환된 뉴클레오시드는 2'-OMe 당 모이어티를 포함한다. 특정 구체예들에서, 상기 2'-치환된 뉴클레오시드는 상기 갭의 위치 2 (5'에서 3' 방향으로)에 있다. 특정 구체예들에서, 상기 갭머는 5'에서 3' 방향의 순서로 당 모티프: eeeeedyddddddddeeeee 또는 eeeeedyddddddkkee를 갖고; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 'e' 는 2'-MOE 당 모이어티를 나타내고, 그리고 "y"는 2'-OMe 당 모이어티를 나타낸다.
특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
서열 식별 번호: 196, 274, 352, 430, 508, 2578, 2655, 2732, 2809, 2886, 2963, 3121, 3122, 3190, 3191, 3192, 3262, 3330, 3331, 3332, 3401, 3402, 3575, 3577, 3620, 3624, 3638-3640, 3653-3655, 3662, 3665, 그리고 3669의 핵염기 서열은 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805 내에서 상보성이다.
다음 화합물 번호: 994446-994450, 1040296-1040301, 1055001-1055011, 1342062, 1342063, 1342067, 1342068, 1365271, 1365272, 1365274, 1365294, 1365299, 1365300, 1371818, 1371821, 1371827, 1371829, 1371837,1371843, 1371866, 1371869, 1371871, 1371876, 1385293, 1394156-1394160, 1394162, 1394164, 1394166-1394168, 1394533, 1394544, 1394546, 1394549, 그리고 1394553의 핵염기 서열은 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805 내에서 상보성이다.
특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805내에 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 58% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805내에 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 평균 90% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5472-5552 또는 서열 식별 번호: 2의 459725-459805내에 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내 검정에서 ATXN1 RNA를 평균 52% 감소시킨다.
2.
서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258
특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258은 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258 내에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 17개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 혼합형 윙 갭머이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 5-8-4 MOE 갭머이거나 또는 5-8-4 혼합형 MOE/cEt 갭머이다. 특정 구체예들에서, 상기 혼합형 윙 갭머는 5'에서 3' 방향의 순서로 당 모티프: eeeeeddddddddkkee를 갖고; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다.
특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
서열 식별 번호: 42, 120, 198, 276, 509, 587, 2502, 2579, 2656, 2733, 2810, 2887, 2964, 3585, 3588-3590, 3615, 3618, 3622, 3657, 3660, 3661, 3663, 3664, 그리고 3666-3668의 핵염기 서열은서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258 내에서 상보성이다.
다음 화합물 번호: 994458-994463, 1040327-1040333, 1367569, 1367580-1367581, 1367589-1367591, 1371311, 1371820, 1371823, 1371825, 1371842, 1371865, 1371868, 1371870, 1371873, 1371875, 1371877, 1394161, 1394163, 1394165, 1394524, 1394538, 1394541, 1394543, 1394545, 1394548, 그리고 1394550-1394552는 서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258 내에서 상보성이다.
특정 구체예들에서, 서열 식별 번호: 1의 5906-6005 또는 서열 식별 번호: 2의 460159-460258 내에서 상보성인, 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 26% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 평균 78% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 5906-6005 또는 서열 식별 번호: 2의 핵염기 460159-460258 내에서 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내 검정에서 ATXN1 RNA를 평균 51% 감소시킨다.
3.
서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164
특정 구체예들에서, 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164는 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164 내에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다.
특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
서열 식별 번호: 48, 126, 2044, 그리고 2121의 핵염기 서열은 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164 내에서 상보성이다.
다음 화합물 번호: 994508, 994509, 1040499, 1040450, 1394513, 그리고 1394529의 핵염기 서열은 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164 내에서 상보성이다.
특정 구체예들에서, 서열 식별 번호: 1의 7868-7911 또는 서열 식별 번호: 2의 462121-462145 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 61% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462145 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 평균 79% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 7868-7911 또는 서열 식별 번호: 2의 핵염기 462121-462164 내에서 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내 검정에서 ATXN1 RNA를 평균 53% 감소시킨다.
4.
서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기 462734-462767
특정 구체예들에서, 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기462734-462767은 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기462734-462767 내에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다.
특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
서열 식별 번호: 128, 206, 284, 1045, 1122, 1199, 그리고 1276의 핵염기 서열은 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기 462734-462767 내에서 상보성이다.
다음 화합물 번호: 994525-994527, 1040500-1040503, 1394514, 그리고 1394525의 핵염기 서열은 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기 462734-462767 내에서 상보성이다.
특정 구체예들에서, 서열 식별 번호: 1의 8481-8514 또는 서열 식별 번호: 2의 462734-462767 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 54% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기 462734-462767 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 평균 79% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 1의 핵염기 8481-8514 또는 서열 식별 번호: 2의 핵염기462734-462767 내에서 상보성인 변형된 올리고뉴클레오티드는 생체내 표준 생체내검정에서 ATXN1 RNA를 평균 48% 감소시킨다.
5.
서열 식별 번호: 2의 핵염기 446679-446706
특정 구체예들에서, 서열 식별 번호: 2의 핵염기 446679-446706은 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 2의 핵염기 446679-446706에 대해 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다.
특정 구체예들에서, 서열 식별 번호: 2의 446679-446706은 핫스팟 영역을 포함한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 서열 식별 번호: 2의 446679-446706내에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 17개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 갭머이다. 특정 구체예들에서, 상기 갭머는 MOE 갭머이다. 특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
서열 식별 번호: 2475, 2552, 2629, 2706, 2783, 3627-3630, 그리고 3644의 핵염기 서열은 서열 식별 번호: 2의 핵염기 446679-446706 내에서 상보성이다.
다음 화합물 번호: 1041926-1041930, 1364282, 1365258-1365261, 1365282-1365284, 1365287, 그리고 1394522의 핵염기 서열의 핵염기 서열은 서열 식별 번호: 2의 핵염기 446679-446706 내에서 상보성이다.
특정 구체예들에서, 서열 식별 번호: 2의 446679-446706내에 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 67% 감소시킨다. 특정 구체예들에서, 서열 식별 번호: 2의 핵염기 446679-446706 내에서 상보성인 변형된 올리고뉴클레오티드는 시험관내 표준 세포 검정에서 ATXN1 RNA를 평균 81% 감소시킨다.
6. 추가적 핫스팟 영역
특정 구체예들에서, 아래 표에서 기술된 범위들은 핫스팟 영역을 포함한다. 각 핫스팟 영역은 "서열 식별 번호: 1, 시작 부위" 열에서 확인된 서열 식별 번호:1의 핵염기로 시작되고, "종료 부위 서열 식별 번호: 1, 종료 부위" 열에서 확인된 서열 식별 번호: 1의 핵염기에서 끝난다. 특정 구체예들에서, 변형된 올리고뉴클레오티드는 핫스팟 영역 1-53 중 임의의 영역내 (아래 표에서 특정된 바와 같이)에서 상보성이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 17개 핵염기이다. 특정 구체예들에서, 변형된 올리고뉴클레오티드의 길이는 20개 핵염기이다.
특정 구체예들에서, 상기 갭머는 5-10-5 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 6-10-4 MOE 갭머이다. 특정 구체예들에서, 상기 갭머는 5-8-4 MOE 갭머이거나 또는 5-8-4 혼합형 MOE/cEt 갭머이다. 특정 구체예들에서, 상기 혼합형 윙 갭머는 5'에서 3' 방향의 순서로 당 모티프: eeeeeddddddddkkee를 갖고; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 특정 구체예들에서, 갭머는 갭에서 2'-치환된 뉴클레오시드를 포함한다. 특정 구체예들에서, 상기 2'-치환된 뉴클레오시드는 2'-OMe 당 모이어티를 포함한다. 특정 구체예들에서, 상기 2'-치환된 뉴클레오시드는 상기 갭의 위치 2 (5'에서 3' 방향으로)에 있다. 특정 구체예들에서, 상기 갭머는 5'에서 3' 방향의 순서로 당 모티프: eeeeedyddddddddeeeee 또는 eeeeedyddddddkkee를 갖고; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 'e' 는 2'-MOE 당 모이어티를 나타내고, 그리고 "y"는 2'-OMe 당 모이어티를 나타낸다.
특정 구체예들에서, 상기 변형된 올리고뉴클레오티드의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지 및 포스포디에스테르 뉴클레오시드간 링키지이다. 특정 구체예들에서, 상기 포스포디에스테르 ("o") 및 포스포로티오에이트 ("s") 뉴클레오시드간 링키지는 5'에서 3' 방향의 순서로 배열된다: 특정 구체예들에서, 변형된 뉴클레오티드는 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖고, 이때 각 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, 각 "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다.
하기 표에서 "화합물 번호 범위" 열에서 열거되어 있는 화합물들의 핵염기 서열은 명시된 핫스팟 영역 안에 있는 서열 식별 번호: 2에 대해 상보성이다. 하기 표에서 "서열 식별 번호 범위"에서 열거된 올리고뉴클레오티드의 핵염기 서열은 표적 서열, 서열 식별 번호: 2에 대해 명시된 핫스팟 영역내에서 상보성이다.
특정 구체예들에서, 상기 핫스팟 영역 내에 있는 핵염기에 상보성인 변형된 올리고뉴클레오티드는 하기 표에서 표시된 바와 같이, 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 "시험관내 최저 감소 %" (처리안된 대조군 세포와 비교하여, 최저 감소 %)를 획득한다. 특정 구체예들에서, 상기 핫스팟 영역 내에 있는 핵염기에 상보성인 변형된 올리고뉴클레오티드는 하기 표에서 표시된 바와 같이, 시험관내 표준 세포 검정에서 ATXN1 RNA의 적어도 "시험관내 평균 감소 %" (처리안된 대조군 세포와 비교하여, 평균 감소 %)를 획득한다. 특정 구체예들에서, 상기 핫스팟 영역 내에 있는 핵염기에 상보성인 변형된 올리고뉴클레오티드는 하기 표에서 표시된 바와 같이, 시험관내 표준 세포 검정에서 ATXN1 RNA의 "시험관내 최대 감소 %" (처리안된 대조군 세포와 비교하여, 최대 감소 %)를 획득한다. 특정 구체예들에서, 상기 핫스팟 영역 내에 있는 핵염기에 상보성인 변형된 올리고뉴클레오티드는 하기 표에서 표시된 바와 같이, 피질 조직에서 생체내 표준 생체내 검정에서 ATXN1 RNA의 적어도 "생체내 평균 감소 %" (PBS-처리된 동물과 비교하여, 평균 감소 %)를 획득한다. 사용된 형질전환 마우스 모델로 인해, 서열 식별 번호: 2의 뉴클레오시드 435531-464889를 표적으로 하는 화합물들만 생체내 테스트되었고; "n.d."는 이 범위내에 있는 화합물들에 대한 생체내 데이터가 없음을 나타낸다. 다른 경우들에서, 생체내 평균 감소에는 모든 화합물들이 생체내 테스트된 것이 아니기 때문에, 임의의 주어진 핫 스팟 내 화합물들의 하위 집단이 내포된다.
표 1
참조에 비-제한적인 공개 및 통합
여기에 열거된 문헌 및 특허 간행물의 각각은 전문이 본원 참고자료에 편입된다.
본원에 기재된 특정 화합물, 조성물 및 방법이 특정 구체예들에 따라 구체적으로 기재되어 있지만, 하기 실시예는 본원에 기재된 화합물을 예시하기 위한 역할만 하며, 이에 국한하려는 의도는 없다. 본 출원에서 인용된 각각의 참고 문헌, GenBank 수탁 번호 및 이와 유사한 것들은 그 전문이 본원 참고자료에 편입된다.
본 출원에 수반된 서열 목록은 각 핵염기 서열을 "RNA" 또는 "DNA"로 표시하지만, 실제로 이들 서열들은 임의의 화학적 변형을 조합하여 변형될 수 있다. 해당 분야의 숙련된 기술자는 서열 목록에서, 변형된 올리고뉴클레오타이드를 기재하기 위한 "RNA" 또는 "DNA"와 같은 이러한 표시가 일부 경우들에서 임의적임을 용이하게 이해할 것이다. 예를 들면, 2'-OH 당 모이어티를 포함하는 뉴클레오시드와 티민 염기를 포함하는 올리고뉴클레오티드는 변형된 당 (DNA의 하나의 2'-H 대신 2'-OH)을 갖는 DNA 또는 변형된 염기(RNA의 우라실 위치에 티민(메틸화된 우라실)을 갖는 RNA와 같이 기술될 수 있다. 따라서, 서열 목록에서 제공되는 핵산 서열들을 비롯한, 본원에서 제공된 핵산 서열(그러나 이에 국한되지 않음)은 자연 또는 변형된 RNA 및/또는 DNA의 임의의 조합을 내포하는 핵산들을 포함하고자 하며, 변형된 핵염기들을 가지는 이러한 핵산을 포함하나 이에 제한되는 것은 아니다. 추가 예로써(그러나 이에 국한되지 않음), 핵염기 서열 "ATCGATCG"을 갖는 올리고머 화합물에는 이러한 핵염기 서열을 갖는 임의의 올리고머 화합물들(변형된 또는 변형안된)이 포괄되며, 여기에는 RNA 염기들, 이를 테면, 서열 "AUCGAUCG"을 갖는 염기들을 포함하는 화합물, 일부 DNA 염기들을 갖고, 일부 RNA 염기들, 이를 테면, "AUCGATCG"을 갖는 것들, 그리고 달리 변형된 핵염기, 이를 테면, "ATmCGAUCG"(이때 mC는 5'-위치에 메틸기를 포함하는 시토신 염기를 나타냄)를 갖는 올리고머 화합물들이 포괄된다.
본원에 기술된 특정 화합물들 (가령, 변형된 올리고뉴클레오티드)은 하나 또는 그 이상의 비-대칭 중심을 갖고, 이에 따라 절대적 입체화학 측면에서, 이를 테면, 당 아노머의 경우 (R) 또는 (S), α 또는 β, 또는 이를 테면, 아미노산의 경우 (D) 또는 (L), 등등으로 특정될 수 있는 거울상체, 부분입체이성질체, 그리고 기타 입차이성질체 배위가 발생된다. 특정 입체이성질체 배위를 갖는 것으로 도시되거나 또는 기재된 본원에 제공된 화합물에는 표시된 화합물만 내포된다. 특정되지 않은 입체화학으로 그려지거나 또는 기술된 본원에 제공된 화합물은 달리 명시되지 않는 한, 이들의 스테레오랜덤 및 광학적으로 순수한 형태를 포함하여 이러한 모든 가능한 이성질체들이 내포된다. 유사하게, 달리 명시되지 않는 한, 본원의 호변체(tautomeric) 형태의 화합물 또한 내포된다. 달리 명시되지 않는 한, 본원에 기술된 화합물들은 대응하는 염 형태가 내포되는 것으로 의도된다.
본원에 기재된 화합물들에는 하나 또는 그 이상의 원자가 표시된 원소의 비-방사성 동위원소 또는 방사성 동위원소로 대체된 변형들 또한 내포된다. 예를 들면, 수소 원자를 포함하는 본원의 화합물은 각각의 1H 수소 원자에 대한 모든 가능한 중수소 치환을 포괄한다. 본원의 화합물에 포함되는 동위원소 치환에는 다음의 것들이 내포되지만, 이에 국한되지 않는다: 1H를 대신하여 2H 또는 3H, 12C를 대신하여 13C 또는 14C, 14N를 대신하여 15N, 16O를 대신하여 17O 또는 18O, 그리고 32S를 대신하여 33S, 34S, 35S, 또는 36S. 특정 구체예들에서, 비-방사성 동위원소 치환으로 치료 또는 연구 도구로써 사용하기에 유익한 올리고머 화합물에 새로운 속성들을 부여할 수 있다. 특정 구체예들에서, 방사성 동위원소 치환으로 화합물을 이미징과 같은 연구 또는 진단 목적에 적합하게 만들 수 있다.
특정 조건 하에서, 본 명세서에 개시된 특정 화합물은 산으로 작용한다. 이러한 화합물은 양성자화된(유리 산) 형태로 기술되거나 또는 설명될 수 있거나, 또는 이온화되며, 그리고 양이온(염) 형태와 결합될 수 있지만, 이러한 화합물의 수성 용액은 이러한 형태들 간에 평형 상태로 존재한다. 예를 들면, 수성 용액에서 리고뉴클레오티드의 포스포디에스테르 링키지는 유리 산(free acid), 음이온, 및 염 형태 간에 평형 상태로 존재한다. 달리 명시되지 않는 한, 본원에 기술된 화합물들은 이러한 모든 염 형태가 내포되는 것으로 의도된다. 더욱이, 특정 올리고뉴클레오티드는 이러한 몇 가지 링키지를 보유하는데, 이들 각각은 평형상태이다. 따라서, 올리고뉴클레오티드는 여러 위치에서 모두 평형 상태로 있는 형태의 앙상블 솔루션에 존재한다. 용어 "올리고뉴클레오티드"란 이러한 모든 형태를 내포하는 것으로 의도된다. 도시된 구조들은 필연적으로 단일 형태를 나타낸다. 그럼에도 불구하고, 달리 명시되지 않는 한, 그러한 도면들도 마찬가지로 대응하는 형태들이 내포되는 것으로 의도된다. 본원에서, 화합물의 유리 산을 나타내는 구조에 이어서 "또는 이의 염"이라는 용어에는 양이온과 연합하여 완전히 또는 부분적으로 양성자화된/탈-양성자화될 수 있는 그러한 모든 형태들이 명시적으로 내포된다. 특정 경우들에서, 하나 또는 그 이상의 특이적 양이온이 식별된다.
특정 구체예들에서, 변형된 올리고뉴클레오티드 또는 올리고머 화합물은 나트륨과 함께 수용액에 존재한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드 또는 올리고머 화합물은 나트륨과 함께 수용액에 존재한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드 또는 올리고머 화합물들은 PBS에 존재한다. 특정 구체예들에서, 변형된 올리고뉴클레오티드 또는 올리고머 화합물들은 물에 존재한다. 이러한 특정 구체예들에서, 해당 용액의 pH는 원하는 pH를 획득하기 위해 NaOH 및/또는 HCl로 조정된다.
본원에서, 특정 특이적 투여분량(doses)이 기술된다. 투여분량은 투약 단위(dosage unit) 형태일 수 있다. 명확하게 하기 위해, 변형된 올리고뉴클레오티드 또는 올리고머 화합물의 밀리그램 투여분량(또는 투약 단위)는 상기 변형된 올리고뉴클레오티드 또는 올리고머 화합물의 유리 산 형태의 질량(mass)을 나타낸다. 상기에서 기술된 바와 같이, 수성 용액 안에 상기 유리 산은 음이온 형태와 염 형태로 평형상태이다. 그러나, 투여분량 산출을 목적으로, 상기 변형된 올리고뉴클레오티드 또는 올리고머 화합물은 용매-없이, 나트륨-아세테이트 없이, 무수의(anhydrous), 유리 산으로 존재한다고 추정한다. 예를 들면, 변형된 올리고뉴클레오티드 또는 올리고머 화합물은 나트륨을 포함하는 용액 (가령, 염수) 안에 존재할 때, 상기 변형된 올리고뉴클레오티드 또는 올리고머 화합물은 부분적으로 또는 완전하게 탈-양성자화되고, Na+ 이온과 연합될 수 있다. 그러나, 그럼에도 불구하고, 양성자의 질량(mass)은 투여량의 중량으로 계산되고, Na+ 이온의 덩이는 투여량의 중량으로 계산되지 않는다. 따라서, 예를 들면, 10 mg의 화합물 번호 1371311의 투여분량 또는 투약 단위는 10mg 중량의 완전히 양성자화된 분자의 수와 같다. 이것은 나트륨-아세테이트-없이, 무수의 나트륨화된(sodiated), 10.59 mg의 화합물 번호 1371311에 해당될 것이다. 올리고머 화합물이 콘쥬게이트 기를 포함할 때, 상기 콘쥬게이트 기의 중량은 이러한 올리고머 화합물의 투여분량 산출에 내포된다. 만약 상기 콘쥬게이트 기에 또한 산이 있는 경우, 이 콘쥬게이트 기는 마찬가지로 투여분량 계산을 위해 완전히 양성자화된 것으로 가정된다.
실시예
실시예 1:
시험관내,
단일 투여시 인간 ATXN1 RNA에서 5-10-5 MOE 갭머 변형된 올리고뉴클레오티드의 효과
인간 ATXN1 핵산에 대해 상보성인 변형된 올리고뉴클레오티드를 기획하였고, 시험관내에서 ATXN1 mRNA에 대해 이들의 단일 투여 효과를 테스트하였다. 상기 변형된 올리고뉴클레오티드는 유사한 배양 조건을 갖는 일련의 실험에서 테스트되었다.
하기 표에 있는 변형된 올리고뉴클레오티드들은 혼합형 PO/PS 뉴클레오시드간 링키지를 갖는 5-10-5 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭(gap) 세그먼트(segment)는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 3' 윙과 5' 윙은 각각 5개의 2'-MOE 변형된 뉴클레오시드로 구성된다. 상기 갭머에 대한 모티프는 (5'에서 3' 방향으로) eeeeeddddddddddeeeee이며; 이때 "d"는 2'-β-D-데옥시리보실 당을 나타내고, 그리고 'e'는 2'-MOE 변형된 리보실 당을 나타낸다. 상기 갭머에 대한 뉴클레오시드간 링키지 모티프는 (5'에서 3' 방향으로) sooosssssssssssooss이며; 이때 'o'는 포스포디에스테르 뉴클레오시드간 링키지를 나타내고, 그리고 's'는 포스포로티오에이트 뉴클레오시드간 링키지를 나타낸다. 각 시토신 잔기는 5-메틸 시토신이다.
"시작 부위"는 인간 유전자 서열에서 상보성인 변형된 올리고뉴클레오티드에 대해 5'-최근접 뉴클레오시드를 나타낸다. "종료 부위"는 인간 유전자 서열에서 상보성인 변형된 올리고뉴클레오티드에 대해 3'-최근접 뉴클레오시드를 나타낸다. 하기 표에 열거된 변형된 각 올리고뉴클레오티드는 서열 식별 번호: 1 (GENBANK 수탁 번호 NM_000332.3), 또는 서열 식별 번호: 2에 대해 100% 상보성이다(뉴클레오티드 16296001 ~ 16764000로부터 절두된 GENBANK 수탁 번호 NC_000006.12의 보체). 'N/A'는 상기 변형된 올리고뉴클레오티드가 특정 유전자 서열에 대해 100% 상보성이 아님을 나타낸다.
배양된 A-431 세포를 48시간의 처리 기간 동안 웰당 10,000개 세포의 밀도에서 자유 취입에 의해 4,000nM 농도의 변형된 올리고뉴클레오티드로 처리하였다. 치료 기간이 끝나면, 전체 RNA를 세포에서 단리하였고, ATXN1 RNA 수준을 정량적 실시간 RTPCR로 측정했다. ATXN1 RNA 수준은 인간 ATXN1 프라이머 프로브 세트 RTS37573 (전방 서열 CATCCAGAGTGCAGAGATAAGC, 본원에서 서열 식별 번호: 11로 명시됨; 역(reverse) 서열 ACTCTACCAAAACTTCAACGCT, 본원에서 서열 식별 번호: 12로 명시됨; 프로브 서열 AGAGGATTGAAGACAGCCATAGCCC, 본원에서 서열 식별 번호: 13으로 명시됨)에 의해 측정되었다. ATXN1 RNA 수준을 RIBOGREEN®로 측정하였을 때, 전체 RNA 함량에 대해 표준화시켰다. 결과는 처리안된 대조군 세포와 비교하여, ATXN1 RNA 수준 퍼센트 (대조군 %)로 아래 표에서 제시된다. 각 표는 개별 검정 플레이트의 결과를 나타낸다. 별표(*)가 표시된 화합물 번호는 상기 변형된 올리고뉴클레오티드가 프라이머 프로브 세트의 앰플리콘(amplicon) 영역에 상보성임을 나타낸다. 추가 검정들을 이용하여 이 앰플리콘 영역에 상보성인 변형된 올리고뉴클레오티드의 효능 및 효과를 측정할 수 있다.
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실시예 2:
시험관내,
단일 투여시 인간 ATXN1 RNA에서 5-10-5 MOE 갭머 변형된 올리고뉴클레오티드의 효과
인간 ATXN1 핵산에 대해 상보성인 변형된 올리고뉴클레오티드를 기획하였고, 시험관내에서 ATXN1 mRNA에 대해 이들의 단일 투여 효과를 테스트하였다. 상기 변형된 올리고뉴클레오티드는 유사한 배양 조건을 갖는 일련의 실험에서 테스트되었다.
하기 표에 있는 변형된 올리고뉴클레오티드들은 혼합형 뉴클레오시드간 링키지를 갖는 5-10-5 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 3' 윙과 5' 윙은 각각 5개의 2'-MOE 변형된 뉴클레오시드로 구성된다. 상기 갭머에 대한 모티프는 (5'에서 3' 방향으로) eeeeeddddddddddeeeee이며; 이때 "d"는 2'-β-D-데옥시리보실 당을 나타내고, 그리고 'e'는 2'-MOE 변형된 리보실 당을 나타낸다. 상기 갭머에 대한 뉴클레오시드간 링키지 모티프는 (5'에서 3' 방향으로) sooosssssssssssooss이며; 이때 'o'는 포스포디에스테르 뉴클레오시드간 링키지를 나타내고, 그리고 's'는 포스포로티오에이트 뉴클레오시드간 링키지를 나타낸다. 각 시토신 잔기는 5-메틸 시토신이다.
"시작 부위"는 인간 유전자 서열에서 상보성인 변형된 올리고뉴클레오티드에 대해 5'-최근접 뉴클레오시드를 나타낸다. "종료 부위"는 인간 유전자 서열에서 상보성인 변형된 올리고뉴클레오티드에 대해 3'-최근접 뉴클레오시드를 나타낸다. 하기 표에 열거된 변형된 각 올리고뉴클레오티드는 서열 식별 번호: 1, 서열 식별 번호: 2, 또는 서열 식별 번호: 3 (GENBANK 수탁 번호 NM_001128164.1)에 대해 100% 상보성이다. 'N/A'는 상기 변형된 올리고뉴클레오티드가 특정 유전자 서열에 대해 100% 상보성이 아님을 나타낸다.
배양된 A-431 세포를 48시간의 처리 기간 동안 웰당 10,000개 세포의 밀도에서 자유 취입에 의해 4,000nM 농도의 변형된 올리고뉴클레오티드로 처리하였다. 치료 기간이 끝나면, 전체 RNA를 세포에서 단리하였고, ATXN1 RNA 수준을 정량적 실시간 RTPCR로 측정했다. ATXN1 RNA 수준은 인간 ATXN1 프라이머 프로브 세트 RTS37575 (전방 서열 GTATAGGCTGAGGCTACCTGT, 본원에서 서열 식별 번호: 14로 명시됨; 역(reverse) 서열 GATCCAGGCTCTTCATGAGG, 본원에서 서열 식별 번호: 15로 명시됨; 프로브 서열 ACAGCAGCTCTGGATGAACATTCACT, 본원에서 서열 식별 번호: 16으로 명시됨)에 의해 측정되었다. ATXN1 RNA 수준을 RIBOGREEN®로 측정하였을 때, 전체 RNA 함량에 대해 표준화시켰다. 결과는 처리안된 대조군 세포와 비교하여, ATXN1 RNA 수준 퍼센트 (대조군 %)로 아래 표에서 제시된다. 별표(*)가 표시된 화합물 번호는 상기 변형된 올리고뉴클레오티드가 프라이머 프로브 세트의 앰플리콘 영역에 상보성임을 나타낸다. 추가 검정들을 이용하여 이 앰플리콘 영역에 상보성인 변형된 올리고뉴클레오티드의 효능 및 효과를 측정할 수 있다.
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실시예 3: 변형된 올리고뉴클레오티드의
다중 투여에 있어서
시험관내,
인간 ATXN1 RNA 상에서 효과
A-431 세포에서 상기 실시예들에서 선택된 변형된 올리고뉴클레오티드의 다양한 투여분량에 대해 테스트하였다. 하기 표에서 명시된 바와 같이 다양한 농도의 변형된 올리고뉴클레오티드를 자유 취입을 이용하여 웰당 10,000개 세포 밀도로 배양된 A-431 세포들을 테스트하였다. 대략적으로 48 시간의 처리 기간 후, 상기 세포들로부터 전체 RNA를 단리시켰고, 정량적 실-시간 RTPCR을 이용하여 ATXN1 RNA 수준을 측정하였다. 상기에서 기술된 바와 같이, 인간 ATXN1 프라이머 프로브 세트 RTS37573을 이용하여 RNA 수준을 측정하였다. RIBOGREEN®에 의해 측정하였을 때, 전체 RNA 함량에 따라 ATXN1 수준이 조정되었다. 처리안된 대조군과 비교하여, ATXN1 RNA 양의 감소 퍼센트로 결과를 하기 표에서 나타낸다. 가능한 경우, 변형된 각 올리고뉴클레오티드의 최대 저해 농도의 절반 (IC50)은 엑셀에서 데이터를 로그/선형 플롯 상에서 선형 회귀를 이용하여 산출하였다.
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실시예 4: 인간 ATXN1 핵산에 상보성인 변형된 올리고뉴클레오티드를 기획
아래 표에서 나타낸 바와 같이, 변형된 올리고뉴클레오티드들을 기획하고, 합성하였다.
표 53의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-10-5 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeddddddddddeeeee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sooosssssssssssooss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
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표 54의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-10-5 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeddddddddddeeeee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sssosssssssssssosss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
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표 55의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 6-10-4 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 6개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 4개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeeddddddddddeeee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sooooossssssssssoss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
표 55
표 56의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-8-4 MOE/cEt 갭머들이다. 상기 갭머의 길이는 17개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 8개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 2개의 cEt 뉴클레오시드와 2개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeddddddddkkee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sssosssssssssoss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
표 56
표 57의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-8-4 혼합형 갭머들이다. 상기 혼합형 갭머는 갭의 위치 2에 혼합형 cEt/MOE 윙과 2'-OMe 변형된 뉴클레오시드를 갖는다. 상기 갭머의 길이는 17개 뉴클레오시드이며, 이때 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 3' 윙 세그먼트는 2개의 cEt 뉴클레오시드와 2개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭의 길이는 8개의 뉴클레오시드이며, 그리고 이 갭의 위치 1, 3, 4, 5, 6, 7, 및 8 (5' 단부로부터 카운팅하였을 때)에 2'-β-D-데옥시리보실 당 모이어티와 상기 갭의 위치 2 (5' 단부로부터 카운팅하였을 때)에 2'-OMe 뉴클레오시드를 포함하는 뉴클레오시드를 갖는다. 상기 혼합형 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeedyddddddkkee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 'y'는 2'-O-메틸 리보스 당 모이어티를 나타내고, 'k'는 cEt 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sssosssssssssoss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
표 57
표 58의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-8-4 MOE 갭머들이다. 상기 갭머의 길이는 17개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 8개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 4개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeddddddddeeee; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sssosssssssssoss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
표 58
표 59의 화합물들은 혼합형 뉴클레오시드간 링키지를 갖는 5-10-5 MOE 갭머들이다. 상기 갭머의 길이는 20개 뉴클레오시드이며, 이때 중심 갭 세그먼트는 10개의 2'-β-D-데옥시뉴클레오시드로 구성되며, 5' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성되며, 그리고 3' 윙 세그먼트는 5개의 2'-MOE 뉴클레오시드로 구성된다. 상기 갭머의 당 모티프는 (5'에서 3' 방향으로): eeeeeddddddddddeeeee이며; 이때 'd'는 2'-β-D-데옥시리보실 당 모이어티를 나타내고, 그리고 'e'는 2'-MOE 당 모이어티를 나타낸다. 상기 갭머는 뉴클레오시드간 링키지 모티프 (5'에서 3' 방향으로): sooosssssssssssooss를 갖고; 이때 "s"는 포스포로티오에이트 뉴클레오시드간 링키지를 나타내며, "o"는 포스포디에스테르 뉴클레오시드간 링키지를 나타낸다. 모든 시토신 잔기는 5-메틸시토신이다.
표 59
실시예 5: 렛(rat)에서 인간 ATXN1에 상보성인 변형된 올리고뉴클레오티드의 장기(long-term)적 내약성 평가
동일한 조건에서 실행되는 별개 연구에서, 위에서 설명한 변형된 올리고뉴클레오티드를 Sprague Dawley 렛에서 테스트하여 올리고뉴클레오티드의 장기적 내약성을 평가했다. Sprague Dawley 렛 각각에게 3mg의 올리고뉴클레오티드 또는 PBS의 단일 척추강내(IT) 전달 투여분량을 제공했다. 각 동물의 체중을 측정하고, 훈련된 관찰자를 통하여 이상 반응에 대해 매주 평가했다. 이상 반응은 PBS-처리 대조군 동물에서 전형적이지 않은, 예를 들면, 비정상적인 사지 벌림, 비정상적인 보행, 떨림, 비정상적인 호흡, 마비 및 경련을 비롯한, 그러나 이에 국한되지 않는 신경학적 기능 장애로 정의되었다. 화합물 번호 994509, 화합물 번호 1040500, 화합물 번호 1041927, 화합물 번호 1055001, 화합물 번호 1371311, 또는 화합물 번호 1385293로 처리된 동물들은 이 연구 기간 동안 이상 반응을 가지지 않았다.
실시예 6: 유전자삽입된(transgenic) 마우스에서 인간 ATXN1에 상보성인 변형된 올리고뉴클레오티드의 활성
유전자삽입된 마우스는 Drs. Harry Orr and Michael Koob, the University of Minnesota 실험실에게 개발되었다. 상기 구조체는 전체 3' UTR (Banfi et al. Nat. Genet. 7: 513-520, 1994) (서열 식별 번호:2의 뉴클레오시드 435531-464889가 내포된)이 내포된, 인간 Atxn1 엑손 8, 인트론 8 및 엑손 9, 이의 측면에 FLP 재조합효소용 Frt 부위, 그리고 CRE 재조합효소용 LoxN 부위의 측면에 선별 표지 Hygro를 함유한다. 상기 구조체는 마우스의 배반포(blastocysts)로 주사되었다. 인간 서열의 엑손 8, 인트론 8 및 엑손 9를 마우스의 Atxn1 엑손 7, 인트론 7, 및 엑손 8로 대체한다. Hygro 카세트는 인간 코딩 서열 엑손 8 및 엑손 9를 발현시키는 키메라 마우스를 생성하기 위해, 재조합을 통해 제거되었다. 인간 RNA 발현은 이 모델의 뇌와 척수에서 발견된다. 190번 아미노산에 중단 코돈을 야기하지 않는, 1개 염기 결손이 있고, 그래서 단백질이 생성되지 않는다.
상기 기술된 변형된 올리고뉴클레오타이드의 활성을 시험하기 위해 상기 기술된 유전자삽입된 마우스가 사용되었다.
처리
ATXN1 유전자삽입된 마우스들을 300 μg의 변형된 올리고뉴클레오티드를 단일 ICV 볼루스로 처리하였다. 3-4 마리의 마우스 그룹에게 각 처리일에 PBS를 투여하였고(음성 대조군), PCR 값은 같은 날 처리된 PBS 대조군에대해 정규화하였다. 일부 경우들에서, 주어진 변형된 올리고뉴클레오티드로 처리된 개별 마우스는 상이한 날짜에 처리되었으며, 그리고 아래 표에서 변형된 각 올리고뉴클레오티드에 대한 보고된 결과는 변형된 각 올리고뉴클레오티드에 대해 1-5 마리의 처리된 마우스를 나타내는 1-3회 독립적인 실험에 걸쳐 평균을 나타낸다.
RNA 분석
처리-후 2주 시점에서, 마우스를 희생시키고, 프라이머 프로브 세트 RTS37573 (상기 본원에 기술됨)을 사용하여, ATXN1의 RNA 발현의 실시간 qPCR 분석을 위해 피질 뇌 조직으로부터 RNA를 추출하였다. 결과는 마우스 시클로필린 A에 대해 정규화된 PBS 대조군에 대한 RNA의 변화 백분율로 표시된다. "n.d."로 표시된 데이터 (데이터 없음)은 해당 화합물에 대한 해당 조직에 대한 데이터가 없음을 의미한다.
하기 표에 나타난 바와 같이, 변형된 올리고뉴클레오티드를 사용한 처리는 PBS 대조군과 비교하여, ATXN1 RNA의 감소를 초래하였다.
표 60
실시예 7: 유전자삽입된(transgenic) 마우스에서 다중 투여분량의 인간 ATXN1에 상보성인 변형된 올리고뉴클레오티드의 활성
상기에서 기술된 ATXN1 유전자삽입된 마우스에서 상기에서 기술된 변형된 올리고뉴클레오티드를 테스트하였다.
처리
ATXN1 유전자삽입된 마우스를 각 3-4 마리의 마우스 집단으로 나누었다. 각 마우스에게 아래 표에 기술된 투여분량의 변형된 올리고뉴클레오티드의 단일 ICV 볼루스를 제공하였고, 2-주 후 마우스를 희생시켰다. 각 실험에서 PBS를 제공받은 4마리 마우스 집단을 음성 대조군으로 삼았다. 각 표는 별개 실험을 나타낸다.
RNA 분석
2-주 후 시점에서, 마우스를 희생시키고, 프라이머 프로브 세트 RTS37573을 사용하여, ATXN1의 RNA 발현 측정을 위한 실시간 PCR 분석을 위해 피질 뇌 조직으로부터 RNA를 추출하였다. 결과는 마우스 시클로필린 A에 대해 정규화된 PBS 대조군에 대한 RNA의 변화 백분율로 표시된다 (상기 본원에 기술된 프라이머-프로브 세트 m_cyclo24에 의해 측정됨). ED50 값은 GraphPad Prism에서 산출되었다. N/A란 해당 실험에 대해 ED50 값을 안정적으로 계산할 수 없음을 의미한다.
하기 표들에서 나타난 바와 같이, 변형된 올리고뉴클레오티드를 사용한 처리는 PBS 대조군과 비교하여, ATXN1 RNA의 투여분량-의존적 감소를 초래하였다.
표 61
표 62
표 63
표 64
표 65
SEQUENCE LISTING
<110> Ionis Pharmaceuticals, Inc.
<120> COMPOUNDS AND METHODS FOR MODULATING ATXN1
<130> BIOL0355WO
<150> 63/019,089
<151> 2020-05-01
<160> 3669
<170> PatentIn version 3.5
<210> 1
<211> 10636
<212> DNA
<213> Homo sapiens
<400> 1
gaggagagag cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg 60
acctgtttca ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag 120
cagccgcaag acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca 180
tttacacttt acagttttac ctcacaaaaa ctactacaag caccaagctc cctgatggaa 240
aggagcatcg tgcatcaagt caccagggtg gtccattcaa gctgcagatt tgtttgtcat 300
ccttgtacag caatctcctc ctccactgcc actacaggga agtgcatcac atgtcagcat 360
actggagcat agtgaaagag tctattttga agcttcaaac ttagtgctgc tgcagaccag 420
gaacaagaga gaaagagtgg atttcagcct gcacggatgg tcttgaaaca caaatggttt 480
ttggtctagg cgttttacac tgagattctc cactgccacc ctttctactc aagcaaaatc 540
ttcgtgaaaa gatctgctgc aaggaactga tagcttatgg ttctccattg tgatgaaagc 600
acatggtaca gttttccaaa gaaattagac cattttcttc gtgagaaaga aatcgacgtg 660
ctgttttcat agggtatttc tcacttctct gtgaaaggaa gaaagaacac gcctgagccc 720
aagagccctc aggagccctc cagagcctgt gggaagtctc catggtgaag tataggctga 780
ggctacctgt gaacagtacg cagtgaatgt tcatccagag ctgctgttgg cggattgtac 840
ccacggggag atgattcctc atgaagagcc tggatcccct acagaaatca aatgtgactt 900
tccgtttatc agactaaaat cagagccatc cagacagtga aacagtcacc gtggaggggg 960
gacggcgaaa aatgaaatcc aaccaagagc ggagcaacga atgcctgcct cccaagaagc 1020
gcgagatccc cgccaccagc cggtcctccg aggagaaggc ccctaccctg cccagcgaca 1080
accaccgggt ggagggcaca gcatggctcc cgggcaaccc tggtggccgg ggccacgggg 1140
gcgggaggca tgggccggca gggacctcgg tggagcttgg tttacaacag ggaataggtt 1200
tacacaaagc attgtccaca gggctggact actccccgcc cagcgctccc aggtctgtcc 1260
ccgtggccac cacgctgcct gccgcgtacg ccaccccgca gccagggacc ccggtgtccc 1320
ccgtgcagta cgctcacctg ccgcacacct tccagttcat tgggtcctcc caatacagtg 1380
gaacctatgc cagcttcatc ccatcacagc tgatcccccc aaccgccaac cccgtcacca 1440
gtgcagtggc ctcggccgca ggggccacca ctccatccca gcgctcccag ctggaggcct 1500
attccactct gctggccaac atgggcagtc tgagccagac gccgggacac aaggctgagc 1560
agcagcagca gcagcagcag cagcagcagc agcagcatca gcatcagcag cagcagcagc 1620
agcagcagca gcagcagcag cagcagcacc tcagcagggc tccggggctc atcaccccgg 1680
ggtccccccc accagcccag cagaaccagt acgtccacat ttccagttct ccgcagaaca 1740
ccggccgcac cgcctctcct ccggccatcc ccgtccacct ccacccccac cagacgatga 1800
tcccacacac gctcaccctg gggcccccct cccaggtcgt catgcaatac gccgactccg 1860
gcagccactt tgtccctcgg gaggccacca agaaagctga gagcagccgg ctgcagcagg 1920
ccatccaggc caaggaggtc ctgaacggtg agatggagaa gagccggcgg tacggggccc 1980
cgtcctcagc cgacctgggc ctgggcaagg caggcggcaa gtcggttcct cacccgtacg 2040
agtccaggca cgtggtggtc cacccgagcc cctcagacta cagcagtcgt gatccttcgg 2100
gggtccgggc ctctgtgatg gtcctgccca acagcaacac gcccgcagct gacctggagg 2160
tgcaacaggc cactcatcgt gaagcctccc cttctaccct caacgacaaa agtggcctgc 2220
atttagggaa gcctggccac cggtcctacg cgctctcacc ccacacggtc attcagacca 2280
cacacagtgc ttcagagcca ctcccggtgg gactgccagc cacggccttc tacgcaggga 2340
ctcaaccccc tgtcatcggc tacctgagcg gccagcagca agcaatcacc tacgccggca 2400
gcctgcccca gcacctggtg atccccggca cacagcccct gctcatcccg gtcggcagca 2460
ctgacatgga agcgtcgggg gcagccccgg ccatagtcac gtcatccccc cagtttgctg 2520
cagtgcctca cacgttcgtc accaccgccc ttcccaagag cgagaacttc aaccctgagg 2580
ccctggtcac ccaggccgcc tacccagcca tggtgcaggc ccagatccac ctgcctgtgg 2640
tgcagtccgt ggcctccccg gcggcggctc cccctacgct gcctccctac ttcatgaaag 2700
gctccatcat ccagttggcc aacggggagc taaagaaggt ggaagactta aaaacagaag 2760
atttcatcca gagtgcagag ataagcaacg acctgaagat cgactccagc accgtagaga 2820
ggattgaaga cagccatagc ccgggcgtgg ccgtgataca gttcgccgtc ggggagcacc 2880
gagcccaggt cagcgttgaa gttttggtag agtatccttt ttttgtgttt ggacagggct 2940
ggtcatcctg ctgtccggag agaaccagcc agctctttga tttgccgtgt tccaaactct 3000
cagttgggga tgtctgcatc tcgcttaccc tcaagaacct gaagaacggc tctgttaaaa 3060
agggccagcc cgtggatccc gccagcgtcc tgctgaagca ctcaaaggcc gacggcctgg 3120
cgggcagcag acacaggtat gccgagcagg aaaacggaat caaccagggg agtgcccaga 3180
tgctctctga gaatggcgaa ctgaagtttc cagagaaaat gggattgcct gcagcgccct 3240
tcctcaccaa aatagaaccc agcaagcccg cggcaacgag gaagaggagg tggtcggcgc 3300
cagagagccg caaactggag aagtcagaag acgaaccacc tttgactctt cctaagcctt 3360
ctctaattcc tcaggaggtt aagatttgca ttgaaggccg gtctaatgta ggcaagtaga 3420
ggcagcgtgg gggaaaggaa acgtggctct cccttatcat ttgtatccag attactgtac 3480
tgtaggctaa aataacacag tatttacatg ttatcttctt aattttaggt ttctgttcta 3540
accttgtcat tagagttaca gcaggtgtgt cgcaggagac tggtgcatat gctttttcca 3600
cgagtgtctg tcagtgagcg ggcgggagga agggcacagc aggagcggtc agggctccag 3660
gcatccccgg ggaagaaagg aacggggctt cacagtgcct gccttctcta gcggcacaga 3720
agcagccggg ggcgctgact cccgctagtg tcaggagaaa agtcccgtgg gaagggtcct 3780
gcaggggtgc agggttgcac gcatgtgggg gtgcacaggc gctgtggcgg cgagtgaggg 3840
tctctttttc tctgcctccc tctgcctcac tctcttgcta tcggcatggg ccgggggggt 3900
tcagagcagt gtcctcctgg ggttcccacg tgcaaaatca acatcaggaa cccagcttca 3960
gggcatcgcg gagacgcgtc agatggcaga tttggaaagt taaccattta aaagaacatt 4020
tttctctcca acatatttta caataaaagc aacttttaat tgtatagata tatatttccc 4080
cctatggggc ctgactgcac tgatatatat tttttttaaa gagcaactgc cacatgcggg 4140
atttcatttc tgctttttac tagtgcagcg atgtcaccag ggtgttgtgg tggacaggga 4200
agcccctgct gtcatggccc cacatggggt aaggggggtt gggggtgggg gagagggaga 4260
gagcgaacac ccacgctggt ttctgtgcag tgttaggaaa accaatcagg ttattgcatt 4320
gacttcactc ccaagaggta gatgcaaact gcccttcagt gagagcaaca gaagctcttc 4380
acgttgagtt tgcgaaatct ttttgtcttt gaactctagt actgtttata gttcatgact 4440
atggacaact cgggtgccac tttttttttt tttcagattc cagtgtgaca tgaggaatta 4500
gattttgaag atgagcatat attactatct ttaagcattt aaaaatactg ttcacacttt 4560
attaccaagc atcttggtct ctcattcaac aagtactgta tctcacttta aactctttgg 4620
ggaaaaaaca aaaacaaaaa aaactaagtt gctttctttt tttcaacact gtaactacat 4680
ttcagctctg cagaattgct gaagagcaag atattgaaag tttcaatgtg gtttaaaggg 4740
atgaatgtga attatgaact agtatgtgac aataaatgac caccaagtac tacctgacgg 4800
gaggcacttt tcactttgat gtctgagaat cagttcaagg catatgcaga gttggcagag 4860
aaactgagag aaaagggatg gagaagagaa tactcatttt tgtccagtgt ttttcttttt 4920
aagatgaact tttaaagaac cttgcgattt gcacatattg agtttataac ttgtgtgata 4980
ttcctgcagt ttttatccaa taacattgtg ggaaaggttt gggggactga acgagcataa 5040
ataaatgtag caaaatttct ttctaacctg cctaaactct aggccatttt ataaggttat 5100
gttcctttga aaattcattt tggtcttttt accacatctg tcacaaaaag ccaggtctta 5160
gcgggctctt agaaactctg agaattttct tcagattcat tgagagagtt ttccataaag 5220
acatttatat atgtgagcaa gatttttttt aaacaattac tttattattg ttgttattaa 5280
tgttattttc agaatggctt ttttttttct attcaaaatc aaatcgagat ttaatgtttg 5340
gtacaaaccc agaaagggta tttcatagtt tttaaacctt tcattcccag agatccgaaa 5400
tatcatttgt gggttttgaa tgcatcttta aagtgcttta aaaaaaagtt ttataagtag 5460
ggagaaattt ttaaatattc ttacttggat ggctgcaact aaactgaaca aatacctgac 5520
ttttctttta ccccattgaa aatagtactt tcttcgtttc acaaattaaa aaaaaaatct 5580
ggtatcaacc cacattttgg ctgtctagta ttcatttaca tttagggttc accaggacta 5640
atgattttta taaaccgttt tctggggtgt accaaaaaca tttgaatagg tttagaatag 5700
ctagaatagt tccttgactt tcctcgaatt tcattaccct ctcagcatgc ttgcagagag 5760
ctgggtgggc tcattcttgc agtcatactg cttatttagt gctgtatttt ttaaacgttt 5820
ctgttcagag aacttgctta atcttccata tattctgctc agggcacttg caattattag 5880
gttttgtttt tctttttgtt ttttagcctt tgatggtaag aggaatacgg gctgccacat 5940
agactttgtt ctcattaata tcactattta caactcatgt ggactcagaa aaacacacac 6000
caccttttgg cttacttcga gtattgaatt gactggatcc actaaaccaa cactaagatg 6060
ggaaaacaca catggtttgg agcaatagga acatcatcat aatttttgtg gttctatttc 6120
aggtatagga attataaaat aattggttct ttctaaacac ttgtcccatt tcattctctt 6180
gcttttttag catgtgcaat actttctgtg ccaatagagt ctgaccagtg tgctatatag 6240
ttaaagctca ttcccttttg gctttttcct tgtttggttg atcttcccca ttctggccag 6300
agcagggctg gagggaagga gccaggaggg agagagcctc ccacctttcc cctgctgcgg 6360
atgctgagtg ctggggcggg gagccttcag gagccccgtg cgtctgccgc cacgttgcag 6420
aaagagccag ccaaggagac ccgggggagg aaccgcagtg tcccctgtca ccacacggaa 6480
tagtgaatgt ggagtgtgga gaggaaggag gcagattcat ttctaagacg cactctggag 6540
ccatgtagcc tggagtcaac ccattttcca cggtcttttc tgcaagtggg caggcccctc 6600
ctcggggtct gtgtccttga gacttggagc cctgcctctg agcctggacg ggaagtgtgg 6660
cctgttgtgt gtgtgcgttc tgagcgtgtt ggccagtggc tgtggagggg accacctgcc 6720
acccacggtc accactccct tgtggcagct ttctcttcaa ataggaagaa cgcacagagg 6780
gcaggagcct cctgtttgca gacgttggcg ggccccgagg ctcccagagc agcctctgtc 6840
accgcttctg tgtagcaaac attaacgatg acaggggtag aaattcttcg gtgccgttca 6900
gcttacaagg atcagccatg tgcctctgta ctatgtccac tttgcaatat ttaccgacag 6960
ccgtcttttg ttctttcttt cctgttttcc atttttaaac tagtaacagc aggccttttg 7020
cgtttacaat ggaacacaat caccaagaaa ttagtcaggg cgaaaagaaa aaaataatac 7080
tattaataag aaaccaacaa acaagaacct ctctttctag ggatttctaa atatataaaa 7140
tgactgttcc ttagaatgtt taacttaaga attatttcag tttgtctggg ccacactggg 7200
gcagaggggg gagggaggga tacagagatg gatgccactt acctcagatc ttttaaagtg 7260
gaaatccaaa ttgaattttc atttggactt tcaggataat tttctatgtt ggtcaacttt 7320
tcgttttccc taactcaccc agtttagttt gggatgattt gatttctgtt gttgttgatc 7380
ccatttctaa cttggaattg tgagcctcta tgttttctgt taggtgagtg tgttgggttt 7440
tttcccccca ccaggaagtg gcagcatccc tccttctccc ctaaagggac tctgcggaac 7500
ctttcacacc tctttctcag ggacggggca ggtgtgtgtg tggtacactg acgtgtccag 7560
aagcagcact ttgactgctc tggagtaggg ttgtacaatt tcaaggaatg tttggatttc 7620
ctgcatcttg tggattactc cttagatacc gcatagattg caatataatg ctgcatgttc 7680
aagatgaaca gtagctccta gtaatcataa aatccactct ttgcacagtt tgatctttac 7740
tgaaatatgt tgccaaaatt tatttttgtt gttgtagctc tggattttgt tttgttttgt 7800
tttttaagga aacgattgac aatacccttt aacatctgtg actactaagg aaacctattt 7860
ctttcataga gagaaaaatc tccaatgctt ttgaagacac taataccgtg ctatttcaga 7920
tatgggtgag gaagcagagc tctcggtacc gaaggccggg cttcttgagc tgtgttggtt 7980
gtcatggcta ctgtttcatg aaccacaagc agctcaacag actggtctgt tgccttctga 8040
aaccctttgc acttcaattt gcaccaggtg aaaacagggc cagcagactc catggcccaa 8100
ttcggtttct tcggtggtga tgtgaaagga gagaattaca cttttttttt ttttaagtgg 8160
cgtggaggcc tttgcttcca catttgtttt taacccagaa tttctgaaat agagaattta 8220
agaacacatc aagtaataaa tatacagaga atatactttt ttataaagca catgcatctg 8280
ctattgtgtt gggttggttt cctctctttt ccacggacag tgttgtgttt ctggcatagg 8340
gaaactccaa acaacttgca cacctctact ccggagctga gatttctttt acatagatga 8400
cctcgcttca aatacgttac cttactgatg ataggatctt ttcttgtagc actatacctt 8460
gtgggaattt ttttttaaat gtacacctga tttgagaagc tgaagaaaac aaaattttga 8520
agcactcact ttgaggagta caggtaatgt tttaaaaaat tgcacaaaag aaaaatgaat 8580
gtcgaaatga ttcattcagt gtttgaaaga tatggctctg ttgaaacaat gagtttcata 8640
ctttgtttgt aaaaaaaaaa aagcagagaa gggttgaaag ttacatgttt ttttgtatat 8700
agaaatttgt catgtctaaa tgatcagatt tgtatggtta tggcctggaa gaattactac 8760
gtaaaaggct cttaaactat acctatgctt attgttattt ttgttacata tagccctcgt 8820
ctgagggagg ggaactcggt attctgcgat ttgagaatac tgttcattcc tatgctgaaa 8880
gtacttctct gagctccctt cttagtctaa actcttaagc cattgcaact tctttttctt 8940
cagagatgat gtttgacatt ttcagcactt cctgttccta taaacccaaa gaatataatc 9000
ttgaacacga agtgtttgta acaagggatc caggctacca atcaaacagg actcattatg 9060
gggacaaaaa aaaaaattat ttcaccttct ttccccccac acctcattta aatgggggga 9120
gtaaaaacat gatttcaatg taaatgcctc attttatttt agttttattt tgatttttat 9180
ttaatataaa gaggccagaa taaatacgga gcatcttctc agaatagtat tcctgtccaa 9240
aaatcaagcc ggacagtgga aactggacag ctgtggggat attaagcacc cccacttaca 9300
attcttaaat tcagaatctc gtcccctccc ttctcgttga aggcaactgt tctggtagct 9360
aactttctcc tgtgtaatgg cgggagggaa caccggcttc agtttttcat gtccccatga 9420
cttgcataca aatggttcaa ctgtattaaa attaagtgca tttggccaat aggtagtatc 9480
tatacaataa caacaatctc taagaatttc cataactttt cttatctgaa aggactcaag 9540
tcttccactg cagatacatt ggaggcttca cccacgtttt ctttcccttt agtttgtttg 9600
ctgtctggat ggccaatgag cctgtctcct tttctgtggc caatctgaag gccttcgttg 9660
gaagtgttgt ttacagtaat ccttaccaag ataacatact gtcctccaga ataccaagta 9720
ttaggtgaca ctagctcaag ctgttgtctt cagagcagtt accaagaagc tcggtgcaca 9780
ggttttctct ggttcttaca ggaaccacct actctttcag ttttctggcc caggagtggg 9840
gtaaatcctt tagttagtgc atttgaactt gatacctgtg cattcagttc tgtgaatact 9900
gccctttttg gcggggtttc ctcatctccc cagcctgaac tgctcaactc taaacccaaa 9960
ttagtgtcag ccgaaaggag gtttcaagat agtcctgtca gtatttgtgg tgaccttcag 10020
attagacagt cttcatttcc agccagtgga gtcctggctc cagagccatc tctgagactc 10080
gtactactgg atgttttaat atcagatcat tacccaccat atgcctccca caggccaagg 10140
gaaaacagac accagaactt gggttgaggg cactaccaga ctgacatggc cagtacagag 10200
gagaactagg gaaggaatga tgttttgcac cttattgaaa agaaaatttt aagtgcatac 10260
ataatagtta agagctttta ttgtgacagg agaacttttt tccatatgcg tgcatactct 10320
ctgtaattcc agtgtaaaat attgtacttg cactagcttt tttaaacaaa tattaaaaaa 10380
tggaagaatt catattctat tttctaatcg tggtgtgtct atttgtagga tacactcgag 10440
tctgtttatt gaattttatg gtccctttct ttgatggtgc ttgcaggttt tctaggtaga 10500
aattatttca ttattataat aaaacaatgt ttgattcaaa atttgaacaa aattgtttta 10560
aataaattgt ctgtatacca gtacaagttt attgtttcag tatactcgta ctaataaaat 10620
aacagtgcca attgca 10636
<210> 2
<211> 468000
<212> DNA
<213> Homo sapiens
<400> 2
aatattttgc catctgaaaa caaaatattt cagtactaaa ggtaatgaga cagtttcatg 60
agtatggtgt ttatgttgga tcttgcagga agaaatagtt acagattttg gtggcagttt 120
atggctttaa acttaatggc taagaaagta aatgacacat ttcttattaa ttgtttttac 180
catttgggta atatacatat ttagcttcct tgagagaaca tttaaattaa ttgactaact 240
gtaatctgaa ttatgtgttt taatttaagg ttgttaaaat cacgtaaatt aactgcttgt 300
gccaacgtaa aattacaata ttagcttttt tttaactgaa aattatctaa atgtaagatg 360
tctaaaaata gagtggaggt ggattggaca gtttgcagat tatgagttgg aataaaaaca 420
tcgcagttaa gccaaaaaca tggcaaccaa tattttctgt tataaaaata tttgagatga 480
atttagtttt tatgaaagct gtctgaaact gaaatgaata gcagaagctt tctgtttatt 540
cacagtccag taataataat acctgcagca caaagcatac gtcttttcta tataaagcca 600
acaagcttct gctcctttct gaagtcgtct ttgccaagca gggtgttggg ggcgggggtg 660
aggatagggg tgaggggaca ttttacccgg ttatgctctt acgtactaac cttcaccttg 720
acaaagcttg tcaacgaaaa caaaaccagt cagagccttt tcaggaaact gatgttaact 780
gtccactaga ggctgtaatg agaccaacaa tgtcacttta gaccaacccg aggtttaaac 840
cgtaacaata atcgattttt aaatggaaaa aaaaaagttg tagaaatgag taagagtgaa 900
cactagtagt tatacttaaa tagccacata tatgtgcatg gtatttcaaa aatgtgagaa 960
aaaaatattt ccggggctct gcaccttcct cgctcgtatg tttattttta tttatgaagc 1020
acgtaggctc ttgcaggcca gagttgtgta aaaactgaca cttttttttt ggtcatcctg 1080
tgccctgcct cagttggtga ctaaccgtta ggtcataagt aaactcagcc aaaagatctc 1140
tcaaatacag cttacagtca agattggtgg ctttcagaaa gaaacttacg cgaaaggatc 1200
atgtttccag acacttagtt ctaagcacct gaagaaggtc aaatgtcgcc cgacacctac 1260
cggccttcca gaatcatctg caacaagaac gccgcactga gcgcccttag tctggaggcg 1320
cctcctagtc ctccaggtgc cacacctgtt ggcaaggtgc acccatccga agaagattcc 1380
ttcgcgtgga ggtcacacct ggcggcgaga caggcggagg ggcggggtgg tgggagtcgg 1440
agaccgcact gaaaccctga gtccagattt aagttcctcg tcgattctcg agaactgcca 1500
tttgatgctc cggttgcttt ctctgtctcc tacactggtt acctcatttc cgattaaatt 1560
aatgatccga aattagctgc gagaggagtg cgcgggtctc ctttccaggc tagagcggag 1620
tagttccata tcaaagccga tttccggacc tgcgtgcgaa gagagaaaga gggcagggtc 1680
gggcggtcgc cagcgttcgc cggcaggaaa ggtgagggta cctgtgcagt cgggggaccc 1740
cttgaaactt tccggagttg cacgcagagg caatccccgc ggcccccagg cctgggttcc 1800
ggaacgccga agcgacgccg gtttgtggct taacgtgcag ctgatgatca gagtgagccc 1860
tctcagatgc tgctccgagc gcctgggacc aaggacacgt cgggattaga atgggccgac 1920
ctcccctccc cgctggggtg ttgcatcggc tcccagctga agcctgacag cccttggggg 1980
agtcccccag gttgcctgag tagcgccccg ttgtcgttca gtcccctcca actaggtgca 2040
gggacccagg gaggcgcgcg aggaccgacc cgtcaccgct caaattacct catcgcccag 2100
ctccccgccc ccttcccaaa cctggaagga accttgccct ccggtccgcg tctcccctcc 2160
cccgcacccc atcccgagcc actctttggg aaaggtgccc gcctccccgg gcggcgcgca 2220
gcgaagggtt aagggcgcgg gccggccgcc gcgcggtgcg ctcgccgtgc tctgtgcggc 2280
tcgccgggcc gcccgccaga gggtgccccc cacccccatg aagtcggatc cttgagctgc 2340
ggcggcggca gccaactgct ccatatttgg cttctattac acatttacat actggagcga 2400
gcgagcgagc gagcgcgaga gagcgcgagg gagggaggga gggcgggcgg gcggagggag 2460
gagggagggg aggggagcgg gaggaggggg aggaggagga ggaggaggag gaggagagag 2520
cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg acctgtttca 2580
ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag cagccgcaag 2640
acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca tttacacttt 2700
acagtaagtg actatttttt tttcctcctc cgattctttc ccccctcccc cattcccttc 2760
tccccttatt tagattaaaa tccctcctcc cccgatctcc cgagaggggc aaaagcaaca 2820
accagcaaac aaacccaaaa ccccaatcgg ctgcacggaa aacagctgga agaggagcga 2880
aggaaatcga cgcgtcgtgt tctgtgtgtg tgcgtgtgtg tgtgtgtgtg tgtgtatgtg 2940
tgtacataca accgtccccg gctccaggct cccgggccga cacccccact ctgggcgcag 3000
gggcggccgg cgggggggct gtcaggggct gggtgggcgc ccgccgggct agggggcgcg 3060
cccgggcggg gggcgcgggc ggggagagcg gcggcggcgc cccgctcccc cggctgctgg 3120
tccggtcgca agtgcggaga gccatgtcct cctccctccg ggtggcgcag gggggaggcg 3180
gcggctgggg ttggggggtg gtccctttcc cggccgccct cttcccattc ctcctccccg 3240
gagagggcgg tgagagagag ggggtctcac ggagggctgg acttctccgc gggtggtcgc 3300
ccggcctcgg cgccctgggg cgggggtctc ccctcggagg gccggcctcg ccgggtgtgc 3360
ggctgcgggc ggggaaggga ctgctcctgc agccgggacg ggactttgcg cgcggccggg 3420
tgccgggcgg ggggcgcaga ggggtggcct cggggaccgc gcgggggtag cgggtgtgcg 3480
ggtgcctgga gcgcggctgg agtggcggtg acggccctgg ccgccgccgc caccgccgcc 3540
ctgttggtgc ggccgcttcc tgatcatgtg cagcggcagc cgccgcccgg agccgggagc 3600
ccgcgagcgc cccagtccgg gccggcgccc ccgccagcac ccgcggcagg agacgaggag 3660
ccgcggcagg cgctgccctg agccgggagt gaacggctgc gcggctgctg ggagggtgaa 3720
tgaagccagg aggaggggaa ggaggaggag gcggcggccg ccgcggagga ggcgctgcgg 3780
ggattgggat gcgccctgga gccccactgc tcgttcactc tgggccgggc cggagactct 3840
gccactcccg ggggcgccgc cgcctcctcc tacgtggttc cagtgctgcg cgcaggccgg 3900
tcccgcaggg ggcagggaag ggggccggac gggcggagcg agaggtgagg cggtgtcgga 3960
gcgcggcgtg agtgtgagtg agtgtgtgag tgactgtgtg tgtgtatttg tgcgcgcgcg 4020
cgccgggcgg ggggcgaggg ccgtcgcgac gcggaggggg cccttccttg gctacttggc 4080
tgactctgca gcgccccgac ccctcttcag ccccccgcct tcaggctgcc ttcttaaact 4140
ccgtggcttg tgctttcatt ttgtttcaga ccacgtaggg ggctgactga aagggatgaa 4200
acaattcagg ttttctaggg agattgagca agaaccttag tgggggtgga agtagggtgg 4260
tgatcgagac tctgccagaa aacaaaacaa aacaaaaaaa aatccgtttc taaggacggc 4320
ggggattcgg ttcgagcccg tggctgctct gttttgtttt gctttcttgg tatataatcc 4380
tacagataaa agggtaatat aaatatttga gaagagggaa attgctgaag agtagtaagg 4440
gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa cagtcggaag aagctggtta tataatgcgc 4500
gatgtggcta acaagaaagg caagctattt ttattttgtt taccgtatgc tgtgcagtag 4560
ggactcctcc aaactggttc tgtccccgaa gagattctta gcttccctgc gagatccaca 4620
ggatacaatt agcaaaatta gaagacccta ttacacccac agaataaaaa ctaatgcctt 4680
acagtggctt tctccctgca catcctgtcg tgcatgcacg ggaatgtgtg tatgcaaata 4740
agttctcctt tggcaatcta gtagtcacat ctcaatgaca tttgtgtttt ataatgcagg 4800
ctgtttttaa tatttaaaca tcattgttat atattgcaca cagcagtggg tagttacttg 4860
gttattttta ggcacagcta gttacttttt caacagtgtt agctgagaca tttctgtttg 4920
ggttttttag gaggctgcag ttcctagaag ccccccttaa gcccaccctt cggtttattt 4980
gatgggtaaa ggtagtttga tacttgagct ttttttggag tgaagcttat gtctgaggaa 5040
accaccagag agaagagaaa atcctgcaca ggaactcttg gaaagggatt gcaccataac 5100
ggctagcgct gtggcattta atctcctctg attgccctct cactgtgcat gcatcagtca 5160
atattttagc agctccgcaa ataaatggac ttgaatgcca tcttctacat aaagcagagg 5220
ttgaagggct cccctgaacc tcctggctgc ctgtcagtgg tgtaggtttt cggtgcactt 5280
actccagtcc tgatcactca tgtaattaga tcaggctgcc atggcaacag acagtgttcc 5340
tcgtccattc aggtgggttt gtcttgtgcc tgaactactc caagtgtttt atgcacagca 5400
tttatgctgc ccaagccaga cgagagactc cactatttca attgcatctt ctttcagtca 5460
tttggatggg agacactgaa tgaggcttct agctactcaa cttttataaa ggagaccaac 5520
aagctgttct tcctaggtgc agtatgtaaa tgcatctccc cagacagtga aaggagcctg 5580
acaatcctgc tggtgtttat tgtgaacaga tcaacaagta tttggtactt gttagaaacc 5640
tttcagagct cactaaagca acatttcttt tgcagtctgg tgcctttggc cttgcagtca 5700
gtcacttaac cctttcaagt gtgaagagcg ttcatcattt ggaacctcca ttgcccatag 5760
cgatggctgg atttctaaag ggtttactca ggggaataac ttattcggaa aatatattcc 5820
cattgtcaca ttttaaaact tgacagccat cataacaaaa actggtactg acagtaggca 5880
gacattctga atgtattcat tcttaatttg gatctattgg ctgtgatttg aatgatcttt 5940
ggtagtaagt taaaaggatt tttttttcct tagctaagcg agaaacgata gaggcctata 6000
gctagaggac tgatagtgca tggtgctttt ggacaataaa catgtacttt attttaggat 6060
gtaatttagt gagcagttag aaagcagtat tctagtcttt gcattagggc accactgata 6120
aagctggcta agcaaagaga aataatatta tggcaaaaag gaaaaaagga aaagttgctt 6180
tagttgctga agctctgtgc tgctcaggca atccaactaa gtggggcagg gggcgggcgg 6240
gggggagtat tttcataacc ctggtatttg aaagaaaaga taattgagaa ttatgtcttg 6300
atttagttgt gactgccagt cagtttacaa ttttatggcc aacaaagcta aactggtaaa 6360
ttttttcccc cagggctagg attgagagag ctactcaact ctattcccag ggggtttatg 6420
agtttttacc gttttgtgag tttatgtggt tggtaaattc attgtggcct ggtcagatga 6480
agcactgctg tagttaaaat gagctattat ttcttctagc tactcaactt ttataaggtg 6540
gtaaatagat gggaagcaag gatgtcaata ttacacaatg ccttggaggt cctggattct 6600
attttgcaac atatagaaaa atgctttact tgcagtaaaa tgtgaacata tatttttcag 6660
tgcacaaata aattcatgtg aaaataagta taaaaaaatg tacctggtgg gaaccgccaa 6720
aggcaatatt tttccttgcg gatttcgttt taagagggtt tggtaaacag aagtgacact 6780
ttgtcaaaaa tgttacgact agacttcagg acttctgaat tgtcttttac acttagagga 6840
agattaaaca gaaactcttt agccacaaga ttacatgtca aatgcctgta agtttcaaca 6900
tacctaagtc agttgcctag gagtcctggg aaaggccagt gctgagatta ttgaaatatt 6960
agtaaacatt actatgactc ctgtttttgt tgtcattatg gagtccaagg acgcacattt 7020
ctttgaataa tgttgtgcct ttattgtttt tcattctgaa atgtcaagtg gattttactt 7080
ttttgcacat accttgagtg acagtttctg atgactaaca ctaacactca ttttgtttcc 7140
tattaaaagt taagcaataa acatatttta ctaaaattct gaaactcacg taagtaggta 7200
aatgtgggag tgaatgttaa ttctttaaac tgtagttatc tgaaaataac acatagatta 7260
ggatctgaac agcttaaata cttgcatcgg taaagtgaca atagtgaagt aagacaggct 7320
attattttta ggggagagat agattatttg actttccttg ctctgtattt tcagagtaat 7380
tcaatagttc gaatgattag tttctgtgag agatttagat ctgtgcagct taattgcttc 7440
aaataacaga tttagttctg gtcatacttc caaggttatc agaagcaggc cctccttatt 7500
ttgataaaag cattgaaagc aatacattgt agaaatggta atagaaataa taatttctgt 7560
tttaggacct tacatataga acttcctttt ctaagataag aattttaagt catcaattat 7620
gttcacattt tattttcatg taatttagtt taataaaata aatgtactca ttcaaaattt 7680
ttttaagaag tgatatacag tgtcagtttt acagaatttt ttaaatgttg gctgaaagaa 7740
cggtaattac attgagattt ttaaaaatat ataaatgctt aaaattacag aagtaataaa 7800
aagaatggtt ttagacaaat cttatggaaa gttttttatt ttattctttt ataattatat 7860
ttatggatat ttgtctttat tagtgtagta atatatttta taacgctcat aatttgaact 7920
ttcaggctaa tgtactataa atatttgtat tacgcattac taccatccca aatgtaccaa 7980
aacacgttta gagagaacaa ttatggacaa aaaagcaaca agcattatat tttgtttgac 8040
atatttcatg ttagcagaaa tgtttcattg atttttctgt aacttttaat gcatcccatt 8100
tgtggagtaa tgaaaatgta atgataattg ccacaatgta agcaaaaatt gtatcctacc 8160
tgaaaattac tttccagaaa attcatggta gtgtactcag aatttgagac tcaagagggc 8220
agaggtttcc ccgattgtga tgttttgatt tgggctaaga ggaactcttt tttttttttt 8280
ttacacttag gtgcccttta acatgacaag ttttgaatga gttaggtagc agaagttttt 8340
cgtgacagtt attgtagcta ctaacctata gcatctatcc ttctaacgtt caaagaaaat 8400
atatttttct gtcactgtgt atggcaaact ttattttctt gtgcccttaa ttttgttccc 8460
ctttctcaca ttatctcctg gtacttactg accattacct cagttttgtt taggccgtct 8520
ttcttgttaa tcttccaata ttaatagtat tgtattatgt tgctctgctg ggttttaaaa 8580
atattgagta ttccattttt ggtgtatatt attgtataaa atgtcctata aattattttc 8640
tggtatatta ttttgtaagt ttttgcagtg aatacgtgct gccttgcttg tattcttgcc 8700
ttcttccctc tgatggaata caagttatgt aaactctctg tattatccta actagtgcag 8760
caacacaaat acttttgaaa taagaaagca tactcatgca agagtaaagt aatcttctat 8820
ggcatttaca tcatgtttga ccctcctctg cacttcagca aactaggagg aggttgtaac 8880
ttggactcta taaaacctta tctgccaggt gatatgtaaa caggattgtg tgcacacaca 8940
ttgtcatata ggcaaacact ctcccaactg gtgagctcat aaaaagcact gtctgtaaat 9000
ttatggtacc tgcacctcat ttgagaatca agtattttga tgcttaattt gagatgacat 9060
catgatcctc cctccctgct tcctcatcct taaagaagta ctaagattaa atagaatttt 9120
gtcaacttct acttaacttg gccattattt atatttgtaa ctcaacaggc ttcttggtgg 9180
agggactgtg ccttctaaag atctgaaaga ccttatagtg tataacagct taccttcctt 9240
ctctgtacgc acagatcaca tgtggggaaa ccaaggacta caagaattcc ttcttttgca 9300
tatcagtcct cggcaggcaa tcaatgctta aataaatgct tggtgaatgg attagttaga 9360
agtaagaaca ttttggctac tgttcattac tttgaaaagt gctggaaaga agtggaagtt 9420
attttccttt ccagctgggc tgtgctctta aaaatagtga gtgtgtatgg atgaaaataa 9480
tcatgagtac cgagatgtgt tgccatgtac ccaaggataa ttggctcact tacctgttta 9540
cggattattc acattggaga tcatattcat agctccagaa tagtttcttt ctgacatcca 9600
atataaacct gggcctcctt cttcctactg ttacctggcg tgagcttagg aaacccaaac 9660
taagtttaaa atcagcctaa gcaaatgtgc agatcagctc cagtaatcaa agactgaaaa 9720
tcagtccagc attcactagt ttggggatga ttttatagta accctgctac tgattttaaa 9780
aaaatttttt tttctgttta atgtggataa ttggtaatta ccggtattta agaatataat 9840
tttaatggat agggctaaaa aaatacgtta gcagatcgag tcctcaactt cttccgtttc 9900
tatgcatagg ttttacctca caaaaactac tacaagcacc aagctccctg atggaaaggt 9960
atatggaaga ttcattcatt ctttctttca ttcatccatt cacacattca ctcattcatc 10020
atacaatgga aaatttttac ttaaccatgt gcaaggaatt gtggcaaaat gaaaatgaga 10080
tgtacattca gtatttaaat aaagtttagt ggaaagttta gtgaatataa atgcacactt 10140
tacacttttt ttctgcattt tttcctttct tctattccat tggactggta tgctaatagc 10200
tgtgcacttt catcattgtg tttcaagttg catgttgata gataatatat gccacattaa 10260
aattaggctt tggctcaatt actattcaat ccatgcccat tttcacctga tactccttgt 10320
agttaccagc atgtgtttat cagatgattg gctagaatca ttggagaaaa gaatgacagc 10380
ggctggctca aatggggaga ccatcctctt aatttgatgg aagggatgac ctttttgtat 10440
gttggcctcc ctctgagcct tgttgagtaa aaccagacct gccttttgag ctggctggga 10500
tctgtgtaat tctcatacaa cagaatgccg aatgtgatgt tcttaaaatt tgtatttcgg 10560
tgcatagaca cttaaggtgg acttattttt taaagcagtc tattctgttt ttcattttgg 10620
atttcctctc ctgcactccc tcgaccattg caggagcatc gtgcatcaag tcaccagggt 10680
ggtccattca agctgcagat ttgtttgtca tccttgtaca gcaatctcct cctccactgc 10740
cactacaggg aagtgcatca catgtcaggt gagagttttg cgatgctctc tgttttccat 10800
ctgaggataa agtcctgacc tggaaaattg cctcctagcc atgctccctt actttgttgg 10860
ctgttgaata tcattttctt tgcaaactct gtttgggcat agtgtgggaa gttgagaaat 10920
tgccaagatt gttttttaaa acttcgatta aagtatctat ctatttggtt taatctatat 10980
gttcatgaag actttcattt gactttgcga tgattgataa ttgccaattg gggcttgaac 11040
ctcatcattt taattgtcag ttttccttaa tacaattaag aatgctatgc taccagatat 11100
cttaagtcac agtttttgca ttttagatta ctgttgtagt ataatatgtg cgtagcaaaa 11160
cagagaccta tttgtttagg ggaaccagta tttgttgaat cttgaatttc tttgtgtctg 11220
tttggatttt acaacttcct gattttccca cgtacagtaa gtttttctgg cctggagagt 11280
catgcagaca tagggtgtat gcaatggtga tgactcatgg ttctctattg aagaaagggc 11340
cagaggatat tgcctcaaat taaatcagga aggaaaaaga ggtttgctag aacttggggc 11400
agtaagggct tgggaacaca agggtttgag tgtatgtaac caagggagat tgtgaaatag 11460
aaaatagggg atcaatttct atttgccttg gaaatggacc tgcttgaaac tgtgaagaca 11520
gactagatta gaggttccca agcctggcta ggcaacagaa tcacctggag agcttaaaaa 11580
aatagaattt ggagctccac cctagacttg atgaatcaga atgtttcctg ctggaatcat 11640
tgatctgtct aggcactgat gctccacagg tttgggaacc cctgggtcgg ccggtcttcc 11700
agcaactctt cctaagttat gttctgtaga cttagttggt gagaagctca ttctactttt 11760
agcaaatctc ccatttgaaa atttgaattt tcaaaactca tttttcaaga ggtagatgga 11820
tatttgcttt ataacaggtt catttaaaca ataattgacc agatttcttt gaagaaagag 11880
ctgcctcttt accgtaagag ccaattttta agttacatat aaattctctg gcatcttaga 11940
taagagcatg gagctccgta atcaacccat ctggacttaa gatctggagc tgccactatg 12000
accttgagta gtcctatgtc ctttcaatgc ctcagtttat tcatgtataa gatggaggta 12060
atattagaac tttcttatag ggctgctgtg aggatggact ggagtaaaat agtagatata 12120
ctgtgggtag aatagtacct ggtgtatggt ttgtatcttt taacagatgc tatcaagtaa 12180
cttatccctc aacaggttga ttgttatggt catgttttat gatggttgct cctgaaccat 12240
acatgactag aaatatgtaa atatacctgg accttggtct ttggacccac cctgtagaca 12300
tctacggctc tgcaaagcca aggagccttt tatttgtttt tgctgaattt taaattctga 12360
atttatcaca actctctgac tgatgggatg catgtgtggt tttttttttt ttagattgtt 12420
gtaaaatgaa ctgatgaatt gcatgcataa atgtggttat ttgtggtctg agtaaaaata 12480
aacaaaaacc tgagtgactg aagtattatg cctcaggaaa aacagccaaa aaagtcccag 12540
tgggggacaa ggtggaggag ggaagagtca tcacagacac gatactcttg taaaatatgg 12600
aactggattc cttacatttt attggctgtg gattagagag gtgttcttta agtggaaatg 12660
taacctaaag ttacatgcaa aggtaagcct cttaagatct acaagtgtca gctgaatgaa 12720
aaaggtaggg tgggccaggc acagtggctc atgcctttaa tcccagcact ttgggaggct 12780
gaggtgggtg aatcacttga ggtcaggagt ttgagaccag cctggccaac atgatgaaat 12840
cctgtctcta ctaaaaatat aaaaattagc caggcattgt ggcaggttcc tgtaatccca 12900
gctacttggg acactgaggc aggagaatcg cttgaatcct ggaggcagag gttgcagtga 12960
gcccaggtct cgccactgca ctccagcctg ggcgacagag tgagactcca tctcaaaaaa 13020
aaaaaaaaaa aagagaggaa agaaaagaaa aaggtagagt gtcttactgc tactttatct 13080
cttagggatg atactcattt taacggttat gtgctaggct gaaaatcctc acatttagat 13140
ctttggggaa atagtttaat tgcaaatggg ttgagtacac gtgcattttt tttaacctgt 13200
ggtgttgaaa gggagtcatt tgtgataaca gaaatatctc aagaatttta ttgtgaaaaa 13260
acaggcagca aaaagtcata tctcttggtc aatatgggca gcttattgag aagagaccta 13320
ggtttttata atatgttagg caagtttaag tgtcttatga atactaaaat actgacgaag 13380
tagcgcaaag tcaccttgaa ttttaagcgc tgacattttc tatgattgca tttaaagaaa 13440
gcttataagc attatctaaa cattttgcat caataatggc ctcattacag tcctcacgat 13500
tgacggctca acgtaggcag aaaaatagta tcattcatgt tgtactcttt tatattcatt 13560
cagttttttt cttaaaccta cattatagtt ctttctggtt ctagttattt tataaatatg 13620
atacagctat agcaagttat gacctaactt gttcacagtc actatttatg taaagaaatg 13680
attcattcat ttattcattg tgaatttttt taaaactact gcatggtgct gtgggaatgg 13740
aagtgaataa gagctaccgg aaggcagtta ttttcttcct ggtcaggcag gggaaagaag 13800
aaactctctg aaataatgaa tacgaataga atggggttct aacagtgttc taacagtgaa 13860
ggaattcaga agagtgacgc tgagtaggag tgatcaggaa agactttgag gaggagggat 13920
cacttgagtt gagctctgct gactagattg catttctgtg ggaagagatg gatggagcat 13980
gaggaaggcc atgtgtgtgt ctgggacata acaagccaat gcacggtatg taactgacca 14040
ggacattttg actgaagcct aggtgctggt ggacatctga atttctggat tcgagcagac 14100
agtagagagt atgggaataa aactgccgag aggtcaagtc tgaagataaa tttggaggag 14160
tccttggcat aaaagtgatc tttgaaattg ggttcttggg cctggcaaaa agtttgacac 14220
ccaggagggg gatgactgaa ttcagggatg acgtcagctg gtgtagaatg tgtagagaga 14280
aggtaagagg cagcggagag tagcttcaac attgatgtgg catggccttc gtctgccttc 14340
ttttcatgat ctggggtgaa ggaggctggg tggctggagg agttgggtga tgtatgcgtg 14400
ggccataagg actcttctgc agctcaggca ccttggaaac tcagtgctga actacagttc 14460
aatgaaatct tgtcaaaacc tctcttcctt taagaccttt aaaaaaatag gaacttgagc 14520
taattttagc taaatctaat gtgtgtgtgt ataaaaatga atgctgcgtt tgaaattcag 14580
cgtatgcggt atctcgttaa acaaatgatc cttctatttt cctctaaaca gttttattaa 14640
gattttcagt gaagccctgt acgttttaac aacaattcca gcatttcttt gatcttttct 14700
accgttgatt tattcatctc acatgatatg cgtaaatcac aatgtgccat ctacttgact 14760
ctgtagcaat tgttcatttg tggcaattca tttactgtac tttgataaac cacattaatt 14820
tgggtgtgtt ttgtaacttt agaggattcc ctggaggctt tctgcagact ctttaaaatg 14880
tgagatgtgt gtgtttttgt gcgtgcgtgt atactgtata tacctagcta ctagacacag 14940
ctctttgaac aatttggctt cccatttata ctttatagaa aataaagaga tatagaattg 15000
gtgaatcttg ggtctgggga gaaagttagt ctaagacttc ctgatgtaaa gtgaaagaga 15060
aggctggaga tgatgttacg atgatgttag tgagcagtct gatttaatgt aatgagagaa 15120
aatttgagga ttaagttgtg gttttttttt ttggtgctga gttagttagg atgggctctc 15180
tgtgtagccc aaaagggctc agaataaaag cagtgactta tttaactttc atcaaagaca 15240
agaaggttaa gacaggaaca agagggatgg agcaaacaac tccaggggca gatcgttctt 15300
gtctgcaatt atttaatgag catctaatgt atgagacgca ttatgccaac aaggccctct 15360
agggaatatg gagatgatca atagttcaca tttactattc tgcatattaa cttattgaat 15420
cctcattaca gtcctttgag gtaggcatca ttattttctc cattgcacag gcgaggaaac 15480
tgtggcacag agagggtgaa taatttcccc aaggtttccc agctgttaag tgatagaatc 15540
gtgcttggat cccagtctac actctcagcc ctgttcctta agccctgtcc ttaagaagct 15600
tacagtcgag tgcataaggc aaggcatggc ttggagtaat atttaaagag ccatgacaca 15660
ggtaacacag tctaggaagt caggatcaag gaagggtcct tccttggagc cttctctttt 15720
gatgcctgcc tgtctgttca gtcacatatg agctttctga cacaggctgt cccatgcagg 15780
ctttgtggtg ttttctccct ttctttcact cttactcata tctccttgag attcctatgc 15840
actttcaata attattaatt gaagaaaatg atgacagtgg caatttgctt atccgtttca 15900
ggggattggc ttaagttgga tccaaatgtt attcagcatc aagagtctca gcgagatgat 15960
gaacttttga ctcttaaaag aacttcactg ggtcattgct cagcttgcaa gatttggcag 16020
atatgaacta tttgtctctc cagtgtgata ggtggtggtg tggcgctgaa cgcaagctct 16080
aagaataaaa cgtgcagcaa aaggaggtca cgctttagtc agggtggcca taaggaagct 16140
tagaactcac atcccctctg cccctgcctc gcccagtctc attttctctc cttcactaga 16200
acagtgaatg aatctgagct cattcatgtc aagatgatag agaagaaaga tcactttctc 16260
ttagctggct tagggaaggc cagattgtct ttcttacact gagtgaaaaa ttactgagga 16320
cttttgtttt tttttttttt ggtcttcaag gcaacatctc ttgcttttac agacccacgg 16380
aaatcgagaa gaggatgcaa gatttactat tcgtgcccta gcctggcagc ttcagcctac 16440
atcacagctg taatcatatg tgatgcattt ttatttacag attagtaggc tctgactctg 16500
acatatgact aaccgggaag ctcctccctg taacagttgt atgtcgtctg cttcagagaa 16560
ctaattgctt ggcaattccc ctttggtaat tccctcttta ttttctgatg agttacttaa 16620
cagcgatggg cttgttgagc agagcgtgga gtttaatgtg tgctccagaa actccactgt 16680
aggcctgggg gatatgtttt tcgagttctg tttagcttta ctgaaggaac agtgaaacca 16740
ttatatggcc tgttaatatt tcactcaata ccagattaaa caccgagcag cgtgcagttt 16800
tccaaaagaa atcaaaacca ggcttctttt taaaatgtgc ccctgtgcat tagaaaatta 16860
ttaaaaagga atttaatatg tatagaatgt ttaatgatct tttgaaaata tggtttcaaa 16920
tggagtagtc ttccaggacc ctacagagtg agtatggtgt gctgttggac tggtagtttg 16980
gaggctcagt ttctgttgcc tgccctgcaa caggatgact tgtgctactc actgtacctt 17040
gctgggtctc agttttcctg tctccaaaac acaaggaggt tgaaagaaat gatctctcgg 17100
gactcttcta tctctgacat tgtacagttc catgaataga ttttattgta attcttgctc 17160
ccggctcccc caagaccttt gcttctgtca aacatcattt gctgttgttt gactttgtta 17220
gattttgtat ttaattagaa tttatatttt agctattatt atgtcattat ttatagagta 17280
agtcataagc ggtgcctaaa ttcatttatc accccatcta tattagtttc atacctgaat 17340
acttcctccg ctccttttta ctgttcttgc taccatgtcc caaacaacat ccatttctgg 17400
aggtggaatg cagtataact ggaaagaatc tttcagctga ttgtgggatt attttttgca 17460
agaggagtgc agaagctctg cttttctaag cagtaatatc aagggccata ttctgctttt 17520
aatttgcaag tagaaatcgt tttgatgtca tttggtttta cctgcaggtg caggttttag 17580
tctctaggta attccttttc tcttctgcgt caactttccc aattagtgtg tgcagcattg 17640
ccttgtcttt ttggttaatt cataagcagt tcatacagat gcctcttgat tcattgcaat 17700
tattaatagt ttctttaggc agctagtgca aatagaaaag gtgacatttg agagggtttg 17760
ttgttttaat ttatttgttt catagacaga gagggagggt gaaaatgaag gctttaaagt 17820
cagggagatt gaggcttgaa tccttctggc tctggctcct ggctttgtgg tccaggtcac 17880
attccttaaa tctgtgatcc tcaatttcct catctgttga atggggatga taatatcacc 17940
taactcacag aatcactgga aagattaaat gtgcactcac tctctagatg ttgcttatgg 18000
tagtatctca ataactaata aaaacagaca cacacacaca cacacacaca cacacacaca 18060
cacacacgga aggcatagca tttaagagct gaataaaaaa agcaagaaca aaggaaagtg 18120
ctgcatttga ggtatagtca gggtaggagg agcttctcag agcagccagt tttagtaggc 18180
agagtttgaa tctcaaaagg acctttgaaa tttgggaagg actaagcacc ctccactaac 18240
ctgtcagtga cgttttctgc aggtagctct tgggaaggac taagcaccct ccactaacct 18300
ggcagtgacg ttttccgcag gtagctctgc tctacagaaa agagtgttta ctacacatga 18360
ctgataaaaa taccatgttt ttaaacatgt attgcccaaa ccttacaata ataaaggaaa 18420
gccaataaaa gcaaaagttc cctttgattc caccattcca gtccataaat caagttcatt 18480
tttatgtgtt gttttttagt tcttgatgat gtaacttata tctttttttc agttttgtgt 18540
ttcccattta gcataaacat tcttagtaac ttcagctata cagttctcat ttgcaaggat 18600
cacataacat tctatcaggt tgttttatct taatttttaa gtttcctatc atttttggac 18660
attcgagttg tttctaattg tttactgttg taaagccgca gcgaatgtct ttgcacacaa 18720
gtatttaccg aggacacact cacatcagaa ggctcaatac taagttagag ggagcttgct 18780
ctgaattgct ttctaaaagg ctgtaccaat ttacattgtt actaatgata taagaatgtc 18840
tctagcttca atcttaataa ttgtgggact tactattttt tggctaattt aataggctct 18900
ttggttttaa agttttcatt cctttgatcc ctctcagaga tggaacattt ccatctgtgt 18960
ttatttacta attgttcttt ttacaattag caaatggaag tcttgatgtt ttctaatcta 19020
tgtatatgag ctctttatat gttctagata ttaatccatt taaaaagtcc tatttgctac 19080
agctacttcc ctagtccagt gtcctttcat ttcagtgatg atgctttttg ttgtacaacg 19140
gttcaagttt ttatatgatc agcctctctt ttcttctact tgtacccagg gccaacctgg 19200
caggaataaa tgagattacc gcagctcaaa ttctgcacca ggctggcgag tggtccactg 19260
gatggctttg ctgggaatag ctctttcttt cttctgctca cttttcccct tgggaactgt 19320
ttcctgttga agtcccagtc tttctatttc caagggcccc tttccccttc tcccacctgc 19380
ccctcactcc ttgattctca cccaccctgt gccggtttcc tggctgtggc atcctctctg 19440
cccagttctc aaccctccgt tgctgacctg tgtgtttctc agggagccct gtcctgggag 19500
cagtgggtag aaacatgtct ggcagcctcc ctgactaggg cctagagaga tcagtcagga 19560
atctcaggcc tggccaaagt ctaaccatta tccaagtctc tggggtcggg gtctttacaa 19620
cttctgtctt acatttctgc tacgtagcag gctgccctgc taaggaatgg gctccttggc 19680
gctggttttc atccatgtag gaaccagaga ggcacgatgc taccctgatt cctttcctgt 19740
tgtagctctt ctccggggat agctcttcca gtggaaggtt gggaacaact tcctagggat 19800
tgaatttttt gaggaaggct ggtctcaaag tgtgagtttt agctgagtgg ctctgctgag 19860
ctggggtggt ttggcatatg atatacctcc taaatggcct gtctagatgt attgttgttc 19920
tggtccaaca tgtttttcct ctttgaagcc aaaatgaaca tttgttagta tttgaaatct 19980
gctgacatct ctgtttttct taactccctc cctgggttct catggtcctc aggataaagt 20040
ctagaatcct tagcctggct ccataggttt tgaggacctt ccttatctct ccagcctcat 20100
cactcacatg ttgccctgta ttcgtcccac gtcggtccca tcgcacttcc tccttcaagt 20160
gccatactct gttttttgct ccagccttta gacatgttgt tcttcctcct tagaacccag 20220
ctcctctctc tgcactgtct ggctaccttt ccctcattct tgaaatctca gcttagagtc 20280
tcttcctcac gaagcccttg gactagggac tatgttattt gctacctttt ctgggttccc 20340
atagcacccc attcttcccc ttgtataata cttcacaacc cctttcctgg cccagcgata 20400
ggagggactg ccctctttcc agtatgtggc atctagtgaa tgggcaatac atacgggcat 20460
tccccctgtg atgcttatgt tacaaattgg atgtgattcc atctattaat atggactgtg 20520
atgtatataa ttgtggtgtg tataattgtg gtcaggaacc agcatggggt cctgtgaacc 20580
acagtggtgg aaaaagctat ggcacctgtt tgttccactg gctttgtgct ttgtccatca 20640
cacagtgagt gaaaaggtga caaaaatgtg taagaagcct gtgctaagga gaaagaaagg 20700
tccaatgatg aattttctgg aaagaaagct gtacgtaata gagtgctgaa ttcgctcaat 20760
catatttaag ttttatagta ctgcacttat aaccacacaa aacactatta ttattgaaat 20820
tcaatacagg aaaaatgctt ttgtttttga acgtctaaga ctgtcttcct cctcattgaa 20880
aaaattccta ctgaatttcg attatatgaa gatttttaga aatgcagcta ttgcatcgaa 20940
tgaataaatg aatttgaggt tcacgttctt aacatctgtt ttctgacttt gatcagtctc 21000
ctttaagtgc tctcgtggtc atactctgca actcaggtga aagtttctag tgagatagtt 21060
atcccaagga gatactttta tctggaagag agtagttctg aagttctaag tgaggttggt 21120
tggttagatt taggttaagg taccacatgg aaaggagaac tgcttaaagg ggtagggtga 21180
ccatgaaacc ttcttctgca aaccctgctc gtcaagtatg aaaccggtgg ggtaggaggt 21240
ccatctaatc ttatctgtgc ccttttgagt tggccggccg ggtgaccatc catctcctct 21300
gggttgtaaa tgacttcatc tcgaagttgc actgttggtg gtaggtgagg acgccttctc 21360
caggtggagg gagtgcattt gtggttgatg gtgtgagcga ccatatgttg gaccatatgt 21420
cagaacctgt taagagattc tgacaggtat ggaaatgcct cccattggaa actgaagccc 21480
tgggtccttt gaccgctgca gcacccccag aggagagtac cctaaggccc ttttaacctt 21540
gccctgccct ggcaggttcc aaggggaggc agaaatgact ctggatgaat tttgttttga 21600
ttattcttcc ccttttccag gctctgtgtc cagttcacct ctggagctgc ctgggtcact 21660
gcaacccaga ctagagagaa gtatgacccc aagttgtggc ttttattggg agacagcctt 21720
catctaagga agtgggaaag aatgtgttcc ccagctgctg cctttctggt gtctgatctg 21780
atacttttca aaagatagca gttttgtttg gtttgatttg gatttttttt ttcttttgta 21840
agtggtcata gacccataag acaagtttat tattgtattg acagaagaaa aaaatgccat 21900
ggttatttat ttaaaaatct ctttccatac aactttgctt tctattgagt ttgaaggaaa 21960
tatggtgatg gcatctaagc ccaaatttcg gtgttttatt ttggctttcc tgttctgttt 22020
aagcctctgt aaccccttga acctttctct actcttcaga aggaacaagt tatatttttt 22080
ttccatctca acatcgtcca aatgaaccgt actattttaa caatctgtgt aaacagatat 22140
aaaaggagga agactacttt ctttaatttt cctcccagcg agctgcaaag ctgtttcagt 22200
catcctagtg attagcagaa tgtgagtaat aaacaacatt aaaatgaaga aacgtctttc 22260
tgagtaggac cttgaaatgt gggtctcacc agtagtatat gagccttcct cagactaaac 22320
tccatgacac agttcatatc atctttaagt cctggaggga gggtttttta atatgtgtaa 22380
atgaccaaac acagctgttg gctgtcctgc tgtacagaga acattcggtg acctgaaatc 22440
gcaaagtttc tgtctctgaa gggtgcactt aatttaactt tttgccctga agtctcaaga 22500
aatgagactt cctttaaaaa aagtgttctt aaaactttct cattttaaat gtccagggtc 22560
ttcaaagagt atactgggag gaaagtcctg tgtttcctgt ttctcttgta ggactagtca 22620
aaagtaccct ttctcttgat ggtattctgc agtctgagcc tctgatttag taactacagc 22680
ctttaaaacc acagttatcc agaccatgtg cagtggttaa tgtgtcatga gtctgcctca 22740
gctgataata gcacatcaca gaattcagag tgccttagat aaattgtttc agtggatagt 22800
cataatgact gcttgagtag aaaagtaccc tcattttcta ggggagaaaa cagaacctac 22860
gaggttgact gatttactag attccagtgg ttagaaatac atgtagcctg tgctgtaaac 22920
ctgattttct gacttgtagt tcagctctct tctccatctc cttgtacagc caagataccc 22980
cagaaattat ttgcgtttcc gaagttgtag gatgaaaaga catgtctttg cttaactgag 23040
ttagccccct agaacaatat tgagatggag ctggaatggt gaagaaatgc aagagtccaa 23100
tcccttgggt atgtgcaatt cccagttacc ccttgaaaca gtgcttcatt ataaatttag 23160
atgttagagg ctgggcatgg tggctcatgc ctcgaatccc agtgctttgg gaggccaagg 23220
cggtgggatc gcctgaggct aggagttcaa gaccagcctg ggccacagag tgagaccctg 23280
tctctaaaaa aaataaataa ataaataaaa aattatatgt tagatgtttt tatagtgccg 23340
gagcctaaac ttgatggata aacagagaat gattttcatt ttgcagccac tgcaccttta 23400
aagttgagct ttttgaggtg tatttccttt aatgcaccca tgacagcaag gttgaaaaca 23460
tcaggaaatc aaattgatct catatatgga atcttgaaat ttaatgtcat ctgctctgag 23520
aagtccttgt ggatgggaag attgtacaat cagatcattt ctctgtgtag gtatctgctg 23580
tctttctact agatgttaca gaagagatta gaagaagctc ttccagccac ctgtgaatca 23640
gctttattct gctaggcaag aaggagctgg tgctggacat ttgtatctgc aaaaaccatg 23700
agttacttcc ccaataatta agtatctact gttacaacat ctagtggcta atcttttagt 23760
aaaatacact gtccatctct tggtgccaga agcaataact attatgaagc cttttctttc 23820
tttgcagaag tagtttgctg gtgaccatat tgttagttgc agaaatactc agaatctgat 23880
tcacatttag acttgacaga agccagattt tatatctgga aacctcatta gtgaaactgc 23940
aaacaagaca aaggccatct atctctctct taggtgccct cctcaatctc tttacagctt 24000
ttcccccagg agtcaaggag atacagcctg gcagggactt ttgcttggtg atggagtagc 24060
taagaatgtt tctctctaac aggtcacaga acagaaagtg ctggtggaca tctcttcttg 24120
ccccaagatc ttcgttggaa gtccccggga cttggtgtct ttgccgttca aagtgtttat 24180
gaactcgcca ggaggcataa tgtgtcacca ttttattctg ggccacccta aaggatgaca 24240
cccagcttca gagacctcct cttggacgac atccctgaga atcaatgttt tagctgtccc 24300
atagtctgac gtctgtttcc gaccgctttt gagctggcgc aggcttagtc attaatggcc 24360
aggacgatgt taaatgttct gcctgattgg cttgcagcta cacacctttt gtcatttgca 24420
gagcagcaac tccctcttga gctcttgggg agtctttaca caaatacact agaaaaaagg 24480
cacccatcca ttttttttcc atcttggcat tagctcacag gcatagtcct gggatgacct 24540
ggagtagagg cagtggagga taaattcatc ttgcacagac ttgtttgtgc tagttctagc 24600
ctgtctctcg ccacagatct agcttttaaa tactcaagtg attggttttg tgtaggaatg 24660
tgtggattgt tggattggaa gaattttctc cctggatttc tagtgtttac ataagcagat 24720
acaaaaaaaa tttgatcact gatttaaata gcagggctta ttttaaaaag ttatgggtgc 24780
ttcaaggtgg tacagaataa aaatgtcagg gttttttttt tttttttttt taacaagtcg 24840
taacacaacc aaaatgtata tattaatgtt ttgtcaggaa agggtcaaaa tggaaaattt 24900
gcaacaaaga caaactacaa tagaacaagt gcaaacagaa gctgacaaat atatgcccct 24960
cgttgggagt tcagcccatg gaatgttatg taggacaaaa ggaatggaag agatatttca 25020
gtaacatttt gttctctgtc aaaaaccttc tgaaatataa atctgctgtg tattggagaa 25080
tggatacagc aattgattca agttgaatag ctttcattta actagaatat cccacagaaa 25140
gcagttcttg ttctgacaac catatttttg ctttctttca cttaaagaaa attgaattca 25200
tgtttacata tcttataggg ttgttttatg gacaaagaca cgggtcaaac cccatcacag 25260
tggctagtgt tacaacaaat agaaacattt ctaaatgaaa taacatttct aagccagggc 25320
cagtgcctgc agtaataata ctaggttggt attatgaagc catttgcaac tataaataat 25380
tcagtcatag atgtgctttt tttaaaatcc tggtttttta aaattctagt cttttgccaa 25440
tacacacacc catacacata cttcacctat ttgcataata gaggaggaat atgaatatgt 25500
atataataaa gtcactttat tttggacttt ctgaaacaga ttaccttttt tcttctcctc 25560
atgatggctc cctgagttgc ttccaattgt tgaaattcca taattaccca caaatatgga 25620
tgtgcccttc taagggtctt gccatgtcaa ccagcccagc tgaaagctaa tagccagtgt 25680
tagcggttta aggaactgag cttcagaatt gagagccccc agcaaaggaa gttctgtttt 25740
tattctccat ttctactctc ctcaaggaga aattaggtgt ttattgtttt gttttgtttt 25800
ttaaattccc agatcattct ggcattggtc ctggattcgc tgcaaatgta atttttagca 25860
acatctatta ctcctgaaat attttggctc ttcgtggcct gtatgattca gtagactctg 25920
aggttttcca agtacattaa ggacttaaat acagaatgtc ttaaaatttt agggctattg 25980
atcaagagaa agcttctcga ggaataaagt tctgttaggt tttagcccta ttctgctttc 26040
aaaattctta actggatgcc gtctattttg ttttctttct gtgtttataa ctaatttgct 26100
acttgggttt attgttttct tacttagaaa ctactttttt ttttgttttg taaatgcaca 26160
gcacttaaaa atataaaaca gttccaaaca gttccaacct gttcattgtt tataccttga 26220
ccatcttttc tgtcttattg ctgaaccatc gcttctcttt ctacttctct tctgggattt 26280
catcttgctc agctaaaatt ctagtgtgtt attctgaata ttatggctgg agtttcctga 26340
ccaacttctt gcatctgagt ccatttcctg tgcttaaggc tgctggcatt ccattcactg 26400
ctcctagtca aaactgaaac ttctcctgct aatgagatta ggccttacaa cactattaat 26460
ttcttcctct ctatttcttg ctccattgtt atttctcaga gatgaaaatc tatttgtcat 26520
tatgagattc attttggcat cacttactaa agttcccttg gatttttctg ttcttcatac 26580
accctacagc ttcaaactgc aacagtcatc aactggtctt tgacaaatta gttgtctcta 26640
cacatggttt acaatattac actagctgtt taaaaataat taagcttctt tctgtgttct 26700
ttgctgtggg tcaggaactt tacttccttt gccatgcaac acagaagtta atcacaaatg 26760
ggtcctctga accaaataat taaaaataga gcaaagtttc tgaaccaggc ggttggcaga 26820
aacgtctgta cttccatctg tgcatggtta ggaaaatatt tcacgatatt taaatagcat 26880
cagctttgct ctcttttgtg tgagagtgtg tctgtgtgtc tatgcgtaat tcattgcttt 26940
gaaggtttgt ttgactgtta gataatcata taaaaaaagt tactggcaag gaaacaggaa 27000
agcaaatcca ggtgttttgt gcatacattc tttatttacc agtctctgtg aaggagcaat 27060
gatcttgctt ttgcttttct ctctgactga aagtttttgc cttgttatgt gctgcagaaa 27120
actaaataac attgcatttt gactttgaaa tctttatgtc tcttgatttt ccacttacaa 27180
ataacctttg ctaatggctt tggggagctg ttcgtatgta cccgaaatgc tgatgaatct 27240
atttcagttt gaagtgtggc agattaggaa tttctgctct ctggaaaggg gatttatacc 27300
tggaatatgc atcaaattca caaacacttt gcgatatacg tgcagacaca tgagtgactg 27360
gttttgacag gaatttaatc cttcaattgg atttcccttt gttcttgtga gtaatcagta 27420
tctcataaaa tatattcagt tttggctaat tgtacagcta tgatacaact ttaagtttct 27480
aagatgtaaa ttactatgtg atataaagat aattcccctc tagcattttt cttttgtaac 27540
agcctctttt tactcctgaa aagctcttta ttttaaggtt gatttcattc tactaggaga 27600
actgttgtgt tagataacaa ctaatgccca ataaatacac tgaagggaga ttaggaactg 27660
ttaaagaaag aacacaaagc aaatgcctta atttcgttct ttcagaacgt atatatttcc 27720
caaagttgtc agttccttta tgtttctaaa aacttaccag gtaggcatat tcttaatact 27780
ttgataataa aattaaacac tgaaatcaaa gctgtagatt gaacatgctc acattaagtg 27840
aaattaagga gagaggaata catttcatta ttaatgtatc agtgaattct ggagtttagc 27900
catgaatatc agctataatc aataacagtt tgagtattta ggcagtttgt aattcatgaa 27960
atttaaatca gaagggtctt taaacatctt tttgtctaat ctcattttgc attcaattta 28020
attctatttt ttctcagcct actatatgca gagtactatg ctagcaggga aaaataatgc 28080
ggaataagtt gtggcccatg gtttcaaaca gattaatctt tgattactct ttgatgcttt 28140
ttttgtatta tttgagggac agtttttttt tcttttttga gatggagtct cgcactgttg 28200
cctgggctgg agtgcaatgg cacgatctca gctcactgca accttttaaa aagagttaag 28260
tggatcttcc taatgattat tctttgtcaa tgtaagatat taggacttaa tgtattttgt 28320
gaactctgag tacacctaca ggtgagtggt agatatcttc atactttaaa ttactgctgg 28380
attttgtctg taccccgaga cagaattttg gtcttctctt atatatagca gttaatatta 28440
atgaggcttc cctgaaaggg ttcctggata ttcagattct tcacactttt cttataaacc 28500
attagatttg tttcctccat tcatttgggc atcttctagt gacacacgga gtggctctta 28560
aaaaagtgga acttgattgc tgatagtttt attcaataaa tcattgttaa taaatattta 28620
tttgcgatca gaaacacaag gagggagtgt acacactcag aaaagcccac aatgcaggga 28680
gcctgttctt ctaacaataa taatggctgg ctggcatatt gaggatttag gatgtgtcag 28740
tcactgtact aatcacttaa tcctcacagt aaacctacat aggtcattat tatctccacc 28800
ttacagatga ggtaaccggg ttagtagctt gcccaaggtc acagagctag taagtggtgg 28860
gactgggctt catgcatgcc attttaacct tagaccctgt gcttttaact aattatactc 28920
tattgcctac cacctgtgtc attgtagaac ttgcaaaatt atgttcaaaa attgttttta 28980
ctaaatataa aataaaatac agtaaaatag aaatacaaaa gtatattcac aaaataaatg 29040
taaattataa aaaataaggg ttcagtgaac actcctttaa ctctacaccc atattttaaa 29100
attaccatca actggatgtc ctctatgtgg acctccccaa tcttgtcaca ttcttcccac 29160
ctcagaagga accactatag aaacatgacg ttttaaaata tttttaagac taggcacggt 29220
ggctcacgtc tgtaatccca gcactttgag aggccaaggc aggtggatta tttgaggtcc 29280
atagttcgag accagcctga ccaacatggt aaaatcctgt ctttactaaa atacaaaaat 29340
tagcacacgc ctgtggtccc cgctactcag gaggctgagg caggagaatt gcttgaacct 29400
gggaggtcga ggctgcagtg agctgagatt gcaccactac actccagcct gagcgacaga 29460
gtgagactcc atctcaaaaa agtatacata tatttttcac gaaagtacac aaaaatgcac 29520
accagccaga tcactgtttg ttttctctcc tttttctctt cttttttccc tactttttca 29580
tctctcatcc ttcttccttc ttttctcgca ccatcatgga gaacaaagaa gaactgggtc 29640
agaacaaacc tttaaaaagt gaaggcgagc gttccttgcg gggatgccca gtgtcatgac 29700
tagtgttggg aattcttggt gagatgacaa tatttttgcc tcactcaaat gaggcatgcc 29760
cttccaagta aagcatgcta tgttttgtag caaacagaac acctgagaag gatgatttca 29820
tatgactgtg ccaacagatc tctcacaagc ttgtcaggtt ataattcaca aatcttaact 29880
ctatagtcta tagacatttt ttttttatat ggggtctcac tctgtcggtt gcctaggctg 29940
gagtgcagtg gtgagatctt ggctcactgc aatctccgcc tcttgggttc aagcgattct 30000
cctgcgtcag cctccggagt ggctggggtt tcaccatgtt ggccaggctg gttttgaact 30060
cctgaccaca agaaatccac ctaccttggc ctcccaaagt gctgagatta caggcatgag 30120
ccactccacc cagccagtgg ttctttttca tttgagatgg agttttgctc ttgttgccca 30180
ggctggagtg caatggcacg atcttggctc actgtaacct ctccctcccg gattcaagtg 30240
attctcctgc ctcagcctcc caagtagctg ggattacagg catatgccac cacacccagc 30300
taattttgta tttttagtca agatggggtt tctccatgtt ggtcaagctg gtcttgaact 30360
cccgacctcg gcctcccaaa gtaccgggat tataggtgtg aaccaccatg cctggcctgt 30420
ttcttttttt tttccaagag gtcagttctc agtctgttgt ccgaactgga gtgcagtggc 30480
atgatcacag ctttactgca gccttgaacc cttgggctca agtgatcctc ctacctcagc 30540
ctcccgatta gctgggactg ccgctgtgca ccaccacacc caactaattt ttaaaatttt 30600
tttgtagaga cagggtcttg ctatgttgcc aaagcttgtc tcgaactctt ggcctcaagc 30660
catcctcccg cctcggcctc ccaaagtgtt gggattacag acatgagctg ccgtgcctgg 30720
ctgacttgtg gttcttaata gtgtggctct taaaatagca aacatttttg ggaaccaatg 30780
tgagggcact tcataacaca atcaaaaacc attaagtgga atatgttaag ataatgtaac 30840
cttgttgttg tcccttaatg ctttaatgca ggctttcagc aagtagtaat acctggtatg 30900
gtgggtgtaa aactcagaat gggtcccggc atggcaggaa taagagaatt ctttcatcgg 30960
ttggaaaata tgtttgaata attcactaca tttaaaaaat aggtaaagag gcttttggtt 31020
ttggttgcaa attgcactca tccatggaag tttttcaagg gccatacaat tctgtagatg 31080
gaggtggcaa tttaatgcag tcttagctgt ttaggattta gaactatgtt acttttaatt 31140
tacttccatg aaattacaaa aacatgtaat gaagctaaaa agatttcaaa agaagcacat 31200
ctagtcaaac ataaaagtac ttaataaggg catacatgta gaagtatatt agtctttgca 31260
catatttaca tatgtatgtt ttggttgctt aatatttttc aagtgctgca tgcatttgta 31320
tgtgtaaata cagtgtgcac cctttataga actagtgttg ggggactctt ttatcagcta 31380
ttatgatttg gagctttatc aaatggagtg attttttttt gtgtgtgtgt gagatggagt 31440
ctcactctgt tacccagact tgagtggagt ggtgccatct cggcttattg caacctctgc 31500
ctcctgagtt caagcaattc tcctgcctca gcctccaaag tagctggaat tacaggcacc 31560
cattagcacg cctggttaat ttttgtattt tcagtagaga cggggtttca ccatgttggc 31620
caggctggtc tcaaactcct gacctcaagt gatccacctg cctcggcctc ctaaagtgct 31680
gggattacag gcgtgagcca ccacacccgg ccggagtgat attttccaat ggtcatgatt 31740
ctggcctgta acaccaagca gtataacgat gagattgaag tgtgaccatg tgcgtctgcc 31800
tatttttatg ttctatctca tctttttgct tggagaaaaa ttatgttgaa agactacagt 31860
gtgcctataa agcttcaaat atgaaaaaag agctacatat gacactttgt tgcagttagt 31920
ccattgtctc aaaaacatgc tataaaaata tgacaactag aaaagtcttg gcaaatgtag 31980
catgagtgtt gccggtttaa aagccgtgtt tgagtactct aaagtacttt tctgtgacag 32040
ctattactat aggaattggc accagctaag aaaatttaca gtttaatact ttagagcaaa 32100
taattgctta gggtgcttta aatagcacag gaaatgtgta gagtgtttac ttgacatttg 32160
ctatattgaa cactaatact gaaacagatt ctttgaccac agagaatgcc agtgtaggag 32220
gggtgggggt aggtgggaga aagaggcgga gaaggaaacg gcaatacaat tagataaaaa 32280
ttaaatgaca aatgtacttt ttcatgatac agagatatca tggggaaaaa tgcccatttg 32340
tttgatcaag taatcttcta gtgtggtagc agaaagcaaa gtacagacaa cttcctggga 32400
ttaggttcct cctgctaaag gctgtcttca ccagaaggtc aaagccttgc agcccttggt 32460
cgctctggtt tatttttcaa gctcctgaaa gcaagaggaa tgacctccgt ttttattaaa 32520
aaaaaaaaaa aaaaaaaaaa aaaaaagaaa agaaaaaaaa agcctctctc gttatctgtc 32580
taatctgcac atgcttgtga ttttttttta tgacgactct gatgccctca tttctcattg 32640
cagctcagtg cttgtgatgt ttttttcccc tgaatgcatc ttgcactccc agaatcttct 32700
tttcattctt ccctggctct gttaatacgg gtcttatctt agaacggggt ctagtgcagt 32760
ttagtgtagc tcttacatgc agagcatttt ttttttgcac aaactgcttc tcgtggattg 32820
tgattcagtt gcacttaaag ggaaaaatag agtatatttt aggctactaa acctccttcc 32880
atttgtaggc atttgagcca gttatacagt gtctttcagg gagttttaca tgcatatgtt 32940
aataaccagt ggcacctgtg ataggtccag gaatgtgaaa ttgtgcaacg ttaatgacat 33000
ttgtccaagc ttcttccttc tatcttgtca atatgagcta cttttaaata cacaaaggaa 33060
ttttgaaaac accaatcaaa agtcaaaatt tcaccctgca gcatggcccg gcacccagaa 33120
cactcagcaa gaggaaggtc tgtatttatg gcttttccac tgacttgaaa tttgacctgg 33180
aataaatcat gtttaacttc tttatgcttc aattagcttt tgaaagatat gtgtggttgt 33240
gtttagccag tggaaaggca ataactgaag ttcacaacga aaggagaact tgaagggaaa 33300
ttttgttagg aaagaacagt gggcaagaat acaatcttca ggcagggtgc tattcctaaa 33360
aagtcttggt acacatggtt cctaaggaag gtgggacatt ttcttataat attctttctg 33420
tattttgtag aattaagaaa tatattattg tacataaata ttttatatta cattatatat 33480
gtataaatac atttatatat atatatatat atacatactg ttttaccctt taactccaga 33540
aagctttgcg ttcacacatc tttttcccta acttctacct ataaagggat ttttagtgat 33600
aatcttgaat ttaaattgta atcaagcagt aacaaacttc atttaatatg cagacatcta 33660
attttataaa ggaaattcca agttattgtt catttccatt tattaattta tttattttgg 33720
gacggagcct cactcactct gttgcccagg ctggggtgca atggcacaat ctcacgtcac 33780
tgtaatgtcc atctcccggg ttcaggtgat tctcctgccc cagcctcctg agtagctgta 33840
caggcgtgca ccaccatgcc cgactaattt ttgtattttt agtagagatt gggtttcacc 33900
gtgttggtca ggctggtctt gaactcctga cctcaagtga tctgcctgcc tcagcctccc 33960
aaattgctgg gattacaggc gtgcgccatc gcgcttggcc aatttttgaa gtttcttttt 34020
ttaatctgtt gccatctctg agatgagagg tttttcattc atttggggaa aaaggaagaa 34080
aggtaatcaa catttattga gcacctactg tgtgccaaac agactgctaa gcacttagtc 34140
cttaagtacc ctacgtgact gatgttcaga gggccatttt ctctgtgtca ggaatcaggt 34200
gggagggcca gaatccatag aacaaaaata taaccgttgc aatagataat taaaaagagg 34260
gaccttttag ttagtggcac ccaaagcatc atagtgtggg ctgtgagatc tcagtaaacc 34320
agttgttggt aggttccccc aactcagaga cctccatgag ggttggatgg ctggattgca 34380
acatggtgct aaaccacatc tccctggtta agccatttca gttattgcct catttaagtt 34440
gcattgctgt aaaagacata ggtatgacaa gttgcaatgc ctaaaattcg aacgaaagaa 34500
tacaggcttt gaatgttatt cagagcttga ctccggagtc ccagatgcag tttcagggtg 34560
agtaaataca aagccagcag ctcccaagtt tagatgagaa aacatttcaa agaaagccag 34620
cgaacgctta tatatttaac acaatatcca tgactcattt tctctttgct ctctcagtcc 34680
agccgttatt catttaccgc tcaccccaca ggaaagctcc ttttgaagtc tgcctttggc 34740
tactttgcaa aacatataaa tatacacctt gggagaataa gggtgagaga gaaaaaaggc 34800
agaggtcata atttttaatc ctggttctgc caataacaaa ctttgtgacc agatactttg 34860
tacagtaaag gaggatgttt ttaaaaccca ttctcagttg ccagagaggc aggcagtcat 34920
cattctgtag gaagacttgt ttcaggattt ctcagatgtc tgctgtgttt ggattgctga 34980
ggtccctaaa gaaccttccc tttgagtcag ctcgactagg cttttggaag tagccctgga 35040
ggtgtgatag caccttaaaa attcttagta actaggaata aatagaagga gaatgggaag 35100
gaatagaagc tgggtgacgg ggaagggaat gccaagctgt cctgcagctg ggatccacac 35160
ttggtgaagg ttgtgcctgc gtccctcatc tgtggttggg tataccagaa ttttgatatc 35220
tctctagttc gaataccagc cttgacattt accaccttgg ccaagtccct gaacctatct 35280
gtgcctcagt ttcttcatct gaagagtggg gattatagtc aatgtaagga ctaagaaaat 35340
caatatacgt aataccccta gtattcacac ttcacctgct atgatgatat taccattctc 35400
ctttggagtt ttctaactta tttgtgtagc atttagggca aaataccagg catatgggtg 35460
atggcgtgta gtggagttgg tgagagggag accttgagtt gtagaaaggg tgggcagaac 35520
ctggtttctg tcctacatcc cagatgttgc ccatacatat cctgtttgtt tctgaccacc 35580
ctgctttgct gtgagggttc ccagcccctc tgcctttacc tgtcctcatt ctgccccact 35640
gtccatgccc agcatgaatc tccacttctc cgggacggaa agttttcccc agctgcttca 35700
gcccaaacca acttccctcc ccactgccct gtgcgcacag cttatttgat catgtcattt 35760
attgcttcat tttgtggctt agatgtcttg cgtcccagtc agactccatg tgactggagg 35820
cctttgcctc ctttcagctc cagggtagtg tggcagaaag agcaaggagc agggagggaa 35880
gggacctgct ctcttctcca gccctttctc tgtgataaac tcagcatgct ccaggcgttt 35940
aatctctgta atcctcacag cctcctcatg caaaatgagg gtctagacca agtgacctct 36000
acagctgccc ttgcagcttc cccattttag agtagtagat ggtgaataag tatggcccga 36060
atgaatgaac aaatgtgcag tctcaagttg gtcagttgtg gcttaaatta tttttgtgcc 36120
cactggcatc tcggcttggt aaatggagga aacggtctct gacgaatttt cactttcagt 36180
agacagaaat tttgttaatt ttgatcattt tatagtccga atttgtggac acattgaatt 36240
aatatttata ttagtaatat gtctaagaag aaaagatttt ttatgctaac aaataatata 36300
aataatgtca cagactaata acagctaaga gtcagtaata aaggaaattt gtttttaagc 36360
actttggaag ttcctgtttg catgcattat atgattatat atacataatt tgtattacat 36420
tattatataa gctctcttag tctattcatt aagtaatttg atgatcattt tgaaattttt 36480
ttataagtac ttaagagagt taaaactata tttcttcttg aaacattgta atttggactt 36540
gttttcttat tcatattaga tgtcttctct gagcccagtt actgagtatg tagtaacttt 36600
tttgtgtgtt acaataattg acagagacgg tggttcaaat tttcagcatc aaacctcact 36660
ttggaattat ttatttccat tttttctctt acctactagt atatatggat ccaaaattaa 36720
ttgctttttt attatattta atacatctat ttgctttgtg gttttactga tacttgaaaa 36780
ttgtaaacaa ttatgaaaga ttttgaactt taatcatctt aatttgctta attaacataa 36840
tttactagag gagagaaaga gaaaacagac ttggttactt atttatgttt gtaaccacct 36900
ttgtatatgt agtaacacca gagcaggcac ttcataattg aaaaggcttt agggtaataa 36960
gtcactgtct gtttcaaact gtgatgactt tctggaaaaa atagcttttg taatatttgt 37020
catactggcc cagatccaga aagtagtatg ttcagtgtct aattgtactc catatggcct 37080
gaactcttga gcaatccatc tgaagtagga ccctgttaag aaattattct ttgttttttt 37140
ttgagatgaa gtttcgctct tgtcgcccag gctggagtgc aatggcatga tcttggctca 37200
ctgcaacctc cacctcccgg cttcaagcga ttcttctgcc tcagcctcct gagtagagta 37260
gctgggatta caggcaccca gctgtttttt gtctttttag tagagatgga gtttcaccgt 37320
gttggccagg ctagtcttga actcctgacc tcaagtgatc cacccgcctc ggcctcccaa 37380
agtgctggga ctataggtgt gagctaccgg gcccggccaa gaaattattc tatgtcatac 37440
ataattgggt gcaagaggtc ttagtaattt gcattttaaa atgataattg gtatcatcta 37500
cgaagagaag ttctacctta gtgttttagt ttagcagtga cactaagata ttatacatat 37560
gaaaatctct taatgttagt gggcagaact gggaaccctt cccttttttt tttttttttt 37620
gagacagagt cttgctctgc cacccagact ggagtgcagt gatgcaatct tgactcactg 37680
cagcctctgc tcccccgggt tccagcgatt ctcttgcctc agccacctgt gtagctggga 37740
ttacaggcac acgccaccac gcccagctaa tttttgtatt ttagtagaga tggggttttg 37800
ccatgttggc caggctggtc ttgaactcct gacctcaggt gatccgcctg ccttggcctc 37860
ccaaagtgct gggattacag gcatgagcca ctgtgcccgg ctggaacccc tccctcttac 37920
agttcacagg gtataagaag ctactttcta gggcttcatc ttaatatggt gattgagttc 37980
tatattatgg ccaaaaggaa aattatgtgg gtattgtggg gaggaggagt cagagggcta 38040
ggggcaaagc gggcagagaa atatcagctg cctttattta gcaaatattt accagtcgtt 38100
cctgcccata tgcacttgtt ccttgtgtac ttggatctga attgattaaa aaggtctgta 38160
tgtattgagt cttttccctt aggagcgctt aagctttctt ttgatgcttt ttttctcttc 38220
ctttaaaatg gtgcaggaaa atgttggaat aaacatagtc agcttgtgaa aggatgattc 38280
tctcccttat ctgggcataa atattgttga atgtgagaat gtgggagtag ctactgggcc 38340
aaatatgcac aatgagtgca agtgattatt gaccttactg atgagaggaa ggaagagaaa 38400
tactttaaaa ctattttcac agggcatttc aaccaagatg tttttctaaa ttcggtttct 38460
gattcaaaaa ctggatttag ctctttttct tgtttgtttc atctgaacaa atttaccctg 38520
aattgaatgg gagagtgttt cttaatcccc catgtcttta gcagtgagtc atttccatgt 38580
tgttgagaca ttttctagcc tttattgctg tgtgtagttc atgcttttct ctggatgttt 38640
tgactcctta aggaactcgc aataacaaat taacaatcac actcctctgg aatgaaaaca 38700
cgcagtatcg gagtaataaa tagcagttct cgaaacctaa ataaacacag aaaactcagc 38760
tctcgtactt aagaaggctc tagaggagtc cagtgtccaa cattacaagc aagacacacc 38820
atttaaagcc ataggaagtt aacatacttt cattttaatt ttccaaggga tcatgttata 38880
aaaccatata gccacttcca ttcttcaaaa cttaataaac ggttagtttt agtcatctga 38940
cctgccttct ctcaaatgga tcataattta gtttaacagg tttgacatta aaataagttg 39000
tgtttctctg ggaaactcat gttagcctgg acttctccac ttcctgtctt tctctggtga 39060
agctggtaat agtgactgag ctcaggccat ggcgggatcc tcacagccct aagactaggt 39120
gccacctgtg tgctgcaacc cagtaccaaa ataacaggaa aaatctaaag ttatccagat 39180
aaaatatgtc aaattataaa gcctctgagt catgacagta atcaaacctg attctatatc 39240
agcaatcaaa cctgactcta tatcagcttt accaaacact attaatatat cctataataa 39300
aaattaaggc gtcattcctc aggttcttta gcaagtaagt cagtgcatct atctaatttg 39360
ctaaggctga aacctattgt acatagaact cgggtctgaa tggttgtccc gtagaaagtt 39420
ttagagcaga gcaaggttgt aaatagccag ctccagtggc tgtttttcac cctgttcatg 39480
ggttgcttgc cctggttgta tatttagttg cctgtgatgg atggagtgaa gtgcacaggt 39540
cgtctctcag gggtgaacac tgggtttgat tagaggccat tgtcatgaaa gatactccag 39600
ctcttccatg accatacatg cttagaagaa aactttgatg cacaaagaac tgaaagccct 39660
aggcactgga attcctgctc atcaaaaaga cacctaaaaa attcttttgg agacttcatg 39720
aattttctct cgattcatac tgaaggactg gtgccagtaa tatttttcct ctttgcctgt 39780
ttcagtttct catgaagttt ttccatattt agacacactg cccagttaaa gggaatgcca 39840
gtcactcggg gtttaagaca atgaagtatg tacttccctc accaatcagt tgggagagct 39900
gattgggctg aacttccagt ctgaggcatg tgagtcacac acaggcagag atttaaatgt 39960
tattaacatg agaaagatct tttgaacgtg aagtcatcat gcttgaggtt actttgaact 40020
ttcctcatag tctcttttat gatttgtgta agaatcaaca tgctttagtc ttatgttaaa 40080
aaaacacagt cgagtgaaaa tggacatgaa tttaaaattg catgatagcc agaaactttt 40140
catactgtgg aaatgttaca ctgtgataaa catttagtga agctgcttgg ctcatgggct 40200
atttttttaa tggcttttgg gttcagaaat ttcaaaatgt cagattcttt gtaatttaaa 40260
tttccttcta agtaaggaag tgcactatgt tattaatttt aaaaatatat atacttagaa 40320
gttgaaattg tgtaattatc ttaatgctcc agagtctctt ttctgactaa acattggaac 40380
ttattctgtt gaatgcaggg aatttgtcca gaaaagctta aggaaattta gcctacgagg 40440
ggaaatgcgc tagattcata aataaaaggt ttatccaaag gggtgatata gaacatgatt 40500
ttatctataa aagattgtac ttgagttttg tctcttcctc ctccttttag gattaagtaa 40560
tgattgtagc ttagttttta tagttgattt atagtaataa gttatgtgta agctgactgt 40620
gggtagttga actcatttca actgcagaag gatagattgt tgtttaaagg atcatacaaa 40680
aattattatt ttttaataaa atgaaaatgt ccccagagat gttacacctg gaaacttaaa 40740
agtaggaaaa atgataatat agtatgttac tctatctctg gaaggaatga tctctcccac 40800
tgaaaagtaa atagtccaaa gtttacaatg tttagttgaa atagcttata aatcacggca 40860
gtgactttta atccttagta gaattctcct ttatttctga gaagtctgta taaatgttta 40920
tggaaacaca gtctgaaata ttttaaatgt agcataccaa tagtacttaa agagaacttt 40980
acgcatgatc acacacattc agagttgttg ggtaaaaaca ccttgtacct tctttggtag 41040
aaaatacttc tgtatttgcg tgtgtgtgag agagagtgtg tgtgtgtttt aaattcttaa 41100
acataacaga tcttttgaag cagagcagaa aactcgcatg ttactgacac tgcattctca 41160
gccatgggga aagcaacagt gtgtttcagc tttagcaaat tacatgtgtt gactcactaa 41220
agaacctgag taactacacc tcagttttta ttacaggaaa tattaatagt gttttgtaaa 41280
gccaatagag actcaggttt gattactatc atgactcaga gactttataa tttgacatat 41340
tttctctgga taattgtaga tgtttcctgt tattttggat tttttattat cgttatttac 41400
tgtgagtttt gcgctcatat acatgtagcc cagaaaagcg atagtgagat ggttcagtgt 41460
atggaatcag ttttattgaa caaacagtgg ggcaggtggg gggagatact tttttgtaat 41520
tagactatta ttagtgagca cttcctttgg cttttgttca tttaaatgta tcttttcttt 41580
ataacttcac aggacgtgga acatgtaaat gcattttgag ttgaaagcag aaaatcacat 41640
ttcagtaaaa ttaaaagctc aagatttcat tttcttgtaa aatttctaat catccccatt 41700
tgctgaactt tgggcccttt cttggcattg ggaggtcatg gctaatgaat gcatctcctg 41760
ttgcctggct tacagccgcc ccctgctgca gtgccatttg ggagaagtgt gtaatgtgcg 41820
tgcttggact cgttatctcc tttcatttcc tcaacatcag ttaatgctgc atagtttgca 41880
acatgatatt gctttgagtt ggtgcctaat tgtgtaggct ggctagaaga acgaatcttt 41940
gcagtggtca ggtgaggcca ctgagtgtgc ccctttgcgg ccactgcaat aaggtggttg 42000
ggaattcttc atttctgatc actgaacttt tccagaacgt cccaaggctc ccccaggaac 42060
tgtattacag catgacattc tgtgtatgtg ggtttttctg ggagaggatt gtagctttca 42120
atcagatcct ccaagaattc tgtttctcaa aaggttcata ggaaccattt atttagaatt 42180
gaaagatagg cacatcttct gaggaaaaca aatgaaaggc ttaacaaaat gttaaggctg 42240
agttacagaa aacaagccat aagctaccta ttttattcaa ttaaaaataa ccatgacatg 42300
gccattttgt aaattattac attaaatctg cattgcagac atacctggta cgtatttatt 42360
tatttatttt ttaagaggca gggtctccct ctatcaccct ggctggagtg cagtggcatg 42420
atcatagctc actgcagcct caaatacccg ggctcaagca gtcctcttgt tccagcctcc 42480
cgaatatcta gaactacaag gacgtgccac catagctggc tcattttcaa attttttgta 42540
gagacgaggt ctcactatgt tgcccaggct ggtctcgaac tccctggcct caagcagtcc 42600
tcccacctca gcctcccaaa gtgctgggat tataggcatg aacaaccacc cccagccact 42660
tggtacatat ttcaaatgtg gtttgtttct tttgaaataa tgaaaaggaa taatgtttca 42720
gggtttgtgg catccacatt ttgggatggc tacatgccgt aaccttgttc gtagtagctc 42780
ctgattttta tctgtattag aaattgctcg gcatgagaca aatgaggaac atttggggaa 42840
atgtgtgagt aattgagtaa aaactaatag ctgtcttaag ggaaccatct tctggtttgc 42900
atttgtatta ataggtatgc agagcaggaa taatttggaa cgggggagct ggttatcctc 42960
tgggtgtgtc aagcacaaat ctcagattcc attacatctg cacaagtctt gacagtttgc 43020
aaaatgtgcc tagaggtatg cttgataagg acagacattt cttgcctggg ttctaactgt 43080
gtcactgcta gcacagtatc tggcctgaac agcatctaaa gaaatatttt gctggatggg 43140
ttacctcaat gggttctcat agcagccctg tggatataga cacagcatgt tttatcattc 43200
ttttctacag gctcaaagag ggtaattact tactcaggct cacatagctg gtaggaaaag 43260
gatttaggcc tctcctttat accatgcttt agctcgaccc aaataataaa agcaaaaaag 43320
ccatgtttgg atcaactgag ttttaataga agagcattgg agagaggttg taaaccctca 43380
gatattttca aaaataatag taagcattct tgacttgcaa tgcagagaat gtcttaagct 43440
catatgtctt gatggtgcta atcaagtcag gcttttataa ttgagtgaaa gcacagaaaa 43500
ataatttatt cattcttata caaccaagta tttattgaat gtcttttctg caccagacat 43560
ggttgtatgc actgaggacg taacagagaa caaacaaggt tgtctaagtc cctgccctca 43620
gagagcttat gttctcatag tggagacaac cacaagtaaa ttgcataagt agactctatt 43680
tgcagacccc ccaaaataga gtaggatatg ttaggagaaa gagtgatggc aggggcgaag 43740
gggattcttt tgtttggtgg agtcagggaa agtcttaggg gatgggcttt tgtacagaga 43800
ctgcagtaag gtataggagc cagccctgga agatgggagt ggtgaagggt gagatgagaa 43860
tctgaggatg agcactgtaa aggaagagaa tggccaggtg aaggctctga ggccagaagg 43920
agcctttgaa ttgatctaga ggctgcagga gcttggattt tacgctaaat gtgatgggaa 43980
actctgttag ttttccaggg ctgctctaat aaattaccag aaacttggtg ggttaaaaca 44040
acaggaattt gttctctcaa agttctggag ggcagacgtc tgaaatcagg tgtcagccgg 44100
gccacactcc ctcccgaagc tctgttggga gaacctttcc ttgccgctgt catcctctgg 44160
tggttccagg cgttccttgg cttgtggcag cgtcactcca gtctctgcct ctgttttcac 44220
atggccttct cctctgtgtc tgtaccaggt cctctcctgt ctcttagaag aacagtggtc 44280
attggattta ggacccaccc gggaaatcca tgacatttat gtcaggggct ggaaaaggaa 44340
ggacaggtgg gatgtgacca tccggagagc ctatctcagc tgtcatgggt tgtcacaaag 44400
gccattgtgt ggttaatttt tatcttctta ttcttgtttc ctctttaatc tttcattcta 44460
agccctatag ccctgactgg cagattcgct gtcgggtttt tctagttgta gatgacatgc 44520
tttttcttaa agccatcttc atttattaat ctacattcgt ttttaatttt aatgcaccaa 44580
tcaataatta tttcacttga cagtttttga cagcatgctg cttgcgacat ttagctgttt 44640
agcatgaatt caaaaggtga tctatcaatt tgcacaaatg aaataaagtt gctctttctt 44700
cctgtgcttt gggggaatgt ataaaaaaat gtatgtttat ccttccctgg agaatttttg 44760
atgtagaaat actgaatagt tttctatata agaagacaga ggactaaaga gctttaaaat 44820
ttgttgtgct tattttgctt gtatcataaa ttcacgtgaa aggccagatt tctcttaatt 44880
gcgttgatat tgtggagatg aatcattcaa caaatgttta ttaagtgctc attgtgtgca 44940
tggcactctg caaatgttat gggaaataaa gacagagtcc ccgggaaata aagacagagt 45000
ccccaggaag tctagtagtc agagaaacaa agccacttcc caaattatgg tgggtagaaa 45060
aacttaggaa atgacagttt tatcatgcta cataccttca cttaatgaat cctatgtgaa 45120
aattcccagt aaaaacctat gaacaaaagt gtgtggttgt cttcatgtat acattgtgtg 45180
cacacatctg tgcgtacaat gcacagcttt gtatgaagct agctgaaaac taaacagcta 45240
ggctgaactt agctgaaaac taaacagcag gggaaatgtt ctttctcact aaaatcacag 45300
tgttaaaact cttggcagtt cagatggtct ccactgtagc tgttggttta cattttgata 45360
atttaccaaa gagcataata tatttaattc ctagttggat ggtgtaactc aacacagcat 45420
ttccagcgaa acgctttgca aatgggaagt aagcattttc tttggaaacc agcagcttcc 45480
ttactccctt ggttcttctg tgggtataag catgacctat aggttagaag ttctggaaca 45540
gaaggagaaa aatgaattat gtcacagtta acaggaaagg aggtgctttg cattcttgct 45600
ccgttgcagt tagttttgtt ttccttcctt ggtttggggg catttggcct tgcatatcct 45660
ggcaagattt aggcaaaaca ggcactgacc ttctttctgg aatgctcttt cattttgccc 45720
catgcatatt attaagaggc ataattcact gtcatatttt tgtggctaaa agttttctaa 45780
cttctataca ctgagccttt gttttctgct taatagggca aaagagctgg cattttctgg 45840
gcatcattga cccttcacta tgatttagat tttttaaaga aacacataaa ctgttcattg 45900
caccttgttg tgtggcaact ctgccagtca ctaattggta ctgtggatat ttggctgttg 45960
ctcttattta ctttcctctg gtttttacat cacttaatta aatcttgtgc cagtttccat 46020
tctatacatg tatagggaag caaacagaaa ctttgtcctg aagcaccagg ttctttggct 46080
tcatcatcct aaacagctct gtgaaaatca gttgaaagtg agtagagcca gaagtggcgt 46140
gtaagccatg ctgtcagcga gggctggctg gatctgcata cgatcgccgc cttctgcccc 46200
tgcttttgga gactagagat ggcttctggt ctgtgtccag ggcttgccat gctgattcag 46260
agagctatgc cacagatgag cctgagttga gaccatgatg ccagcatatc ctcagaccca 46320
cgagatcgtt atgccagaat gttaatccgc agtggaaacc attactaaca tactctcaag 46380
gcccacatga tgagcacatt ctctctctgt gttaagctgc atgggaatgt aaatcctaac 46440
tggaagctac tttattgatg tgccttgaga aattgctgct ctctggctgc aggtatcagc 46500
agcagtcaca gtgcacatgc tctctaagga agatccatat ggagtcaggt gtttgcttgg 46560
tgagcaggga atcggaacaa gggagtggga tgagttgact gttaagtggc accaagcaaa 46620
catagcctgc ctctctgttc atctcaggag aagggtggct tttctagtgg gaccaggaac 46680
atgtcagtca ttgcctgcta ctccctacag tcatctcact agggtggcct tgcctgtgaa 46740
gacactgtat tctccccaac aaccttggca ttgcctacat agactttagt gactctgtac 46800
tttcctggct aagccagccc tggcgccctt ttgaggacac agtcttttct taaattcatg 46860
actatatttc atcaggtgct ggctggggca ggggtagtgg tgatggtagt aattatcttt 46920
cttcagttgg ctttgtatgt ccatgttctc atccactaaa ttttgttctt actataaacc 46980
gctaactagg caatctcttc cccgttgtca agttcttggt tggggaatgg taatctttat 47040
tgtccttctt ataagtccct ttggaatgga tagaggcttt gggatggaca tctcgtgaac 47100
tgtatcttca tatcaagctc tgtgaactga atggcaacaa ggaggcattc atccagacca 47160
ggagtaggca aactatggtc catgggccaa atccagcctg ttcttgtaaa taaagtttta 47220
ttagcacata gctacatcca ataatttgtc taatgtctat agcagttttt gcactacact 47280
ggcagaattt gatttgagtc atggtgaaag agaccatagt ccaagaaagc ctgaaatatc 47340
tactatctga tcctcatcag aaaatgtttg ccaactgtag tctatacctt tgcacgtcag 47400
agaattgcat cagggaagaa ctagaagccc tccttttgca cccccacaac cctgccacaa 47460
ttcagtgaac aaacagaaga tcagagaggg aatgtgactt gaccaaagtc acacagctgg 47520
ttcataggaa agccaggacc tgagctcaga tcttccagtt cctagtgtat ttgtcttcta 47580
cttttggagg acgttgtgag ttttctggtt tacagatgat taaccattac aacatactga 47640
aagaaagctt ctttagtggt cagagctatt ttccaaactg acttccccag gcaaaatcac 47700
tagccagctt ggcattgata ctcatttatt aatcttacaa acagtaccta ccatatttca 47760
gggatggggc tggggctaag acactgatga agaagcacaa tccctgccct tgggaagttt 47820
ggatgagaag agtggtcaga tagctagata cagagatgca tgtcatttta tctgtagtgt 47880
gttacttatc atcataggac tgtgatcata tggacgaagg atgcgttaat ttagccttga 47940
gtgggtgggg gtgttgtcag gaatggctcc atagggttgg agatgtttga gctctgtctc 48000
aaaggagatt gagttcttca ggtagagaat tgcagcagaa atggctgtgg tcctctaggc 48060
ttgagtgtgc atggtatcca gtaatttggg aatgcttgtc taacacaact agaggtaggg 48120
cttaggggac gtggtatggg gttacaggaa atctagttgg aaaagtaagt tggagccaaa 48180
ctgggaaact tacggcattt caaatgctaa ggagtatgga ctttggctta tattctaggg 48240
gttttctaat ctgtagattc caaaacatat gggagaccac atttcttgta aaagaggacc 48300
tgcacattca taccaacaca aagcatggtc tgtagatttg gtcatcagaa tcactaacag 48360
aaataggagc tttcttccaa atatatgtag ctggctgata ttgtaagtca ttagccagaa 48420
ttcattcaca gcgttactaa gttcatagta tctttttgac cattgtacat cttcttgatc 48480
aacagatatt aagagttaaa catctagtgc ctgaagtctg caacattttt gattgaagaa 48540
aatgttggga accactgccg ttgatggcag tagtcatgaa attttttgaa ttaacacatg 48600
ttataggttc cagagtcagc tgccctaaat tttactagct ttgtgacttt gagcaagtta 48660
tttaacatac ctcagctgta agagtcttta tctctaacgt taaaataata gcctctgtct 48720
cttaagattg ttataaagat atgataatgt ctgaacgcat gtagcatggg gccaggctga 48780
tgggatatac tcatgtttaa atagaagcta ttgtaatgat ttttagcgga tgtggcatat 48840
gcagatgtat tttagatttg acccagtgtg gacgatgagt tcaaaaggga gagttgtacg 48900
accttcctgt tatccaagtg agaaataatg gggccagggt gggcagggga taggttaggg 48960
aaggagaggg gagagggagt atgggaaggt gtatgtccac tttaggtaat gaagtgagaa 49020
atgaaagaag ccacattctg tttcatgccc aaagcaacag acaaggcaca aattagagtg 49080
tagggaagcc agtttctgtg acttgatggc atagaatggt gtggcttatc tggcaaattc 49140
cacgccccgt aactcctgga attgatctgg ataagaattc accttgagta aattttaaaa 49200
attaatttaa taaattaata gccccccctt tgaaacacag aaaaattaga attacagcat 49260
gagtatcttt ttttgctcta aaacagtaca gcccagcagt tcagcctaca cccatcacag 49320
agctttcaaa ggaatgtata caagaaaata catatacaat tacaaatttt aaaaattaag 49380
taacatgtat atactgttaa atatttatat attgatgctt agaaaaagat gggacaaatg 49440
ttaagtgtca gctgggaggt ttttactttc ttctttgcca tttctgtatt tttcaaaatg 49500
aatatgtata taattttaaa atgtgttaac actatttcaa aaggaaaaca atcacaaaaa 49560
ggaatagatt ggaaaagctt caggggactt gctatccttg tctttttggg tagctgttct 49620
acaaaggcgg gtggtggtgg gtgcctccca gctgtgtctc atttcagtca gcggatgctc 49680
tgctaaatct agtgatgggc ggcctacctc cgaaaggtgg gtgggagtga gggatgagtg 49740
tagcagtagt acatgcaaat ggggccaggt tttggtgtgt gtgtgtgtgt gtgtgtgtgt 49800
gtgtgtgtgt gtgtgtgtgg tgtgtggttt tttttttctt tctttttttc tacagtctta 49860
ctctgtcgcc caggctggca tggagtggtg tgatcttggc tcactgcaac ctccgcctcc 49920
tgggttcaag tgattctctg cctcaacctc ccaagtagct gggactagag gtgcacacca 49980
ccacgcctgg ctaatttttg tatttttata aagacgagat ttcacatgtt ggccaggctg 50040
gtctcaaact tctggcctca tgtgatccac ccgctttggc ctcccaaagt actgggatta 50100
taggcatgag ttactacgcg cggccaggga ccagttaaga tttgacgatt acattttatt 50160
gaatgtttgc atcagaggca cctggaaggc ttgtttagac cacagatttc tgggcgccag 50220
gcccaggggt tctgatttaa tagttctagg gtggagcctg agaatatgta tttctgacaa 50280
atccctccgt gaaactgatg ctgctggccc caggaccaca ctttaagtga ggggtagtaa 50340
gcgggtggag aactgcatgg aggatgaaaa gcatccagtt ggattttata tttgctcccc 50400
cttcttcata tacacacact gaaatcactc cactctatgt tttctcagat tctttccctg 50460
tctggaatat ttggttctct cttcatgttc agtcagtaga aacaagaagt aactcttgga 50520
ttgagcagtt ttcacacaag tagcccaaat gatattgaca catcatttct acacagcatc 50580
agcttgttca cacacatacg cccccagagg ccaatggcgt cctttggctt tgttctcctt 50640
tttaaaaatt cagtgagtaa gctaatttta taggaatgtc tcagaaagct attcctgtaa 50700
acccagcgtt tgtaaattga aatagaggaa gcggtgctga ttaccgcaat tgtattgaaa 50760
cttattcatg gagcggtccc tctagattca gatagtttgg acagaaaccc tccaactctt 50820
cccttaccac tccattgttt ggtaaagttt aatgtgctca catggcatct actttttcag 50880
ccagggttaa tactcctagc gattctttca ctggaaggga tgactcagag aggaagagtt 50940
ggcattaatt gcttcatcaa ctatgcttat tatgagtcat ctcttgcttg tcttagtaat 51000
tcagctggaa aaaggagaaa tgttatctct ggttcctgag gccagcttgg gcttcagtga 51060
actaggatac tccctcgtag ccatttgtga gtttcattca gttactaagg gaatgaacag 51120
attgtgaatc tcattatcct agcaggtaca tataaatcta taaatggcga atggcagtta 51180
cttcctgatg tttatcagtg atgagatgcc acaggcagga cgttagccct agaaaggcac 51240
tgttttgaag gtggctgatt aaggggcaaa agaaaaaaaa aaaaagcaaa aacggaggga 51300
tatgttcagg tccctgcctt tactcagttc cctcccctag cttccaattt gattaacaga 51360
ggtgtcgagg gaggaagaga acaatttcca aataaaactg cctttggttc tttttttgag 51420
tgtaatgtgg taactggatt atttggaaac acgaatttag gtctcttact ttctacttct 51480
tgcgttcagt tcactcgtgt cttcctgttt ggtgtatacc ttccccttct gactcagtct 51540
tctctatttc tcttctcact gtagcagacc accgttcttc ccctgcctta ggcgtttctc 51600
acttgctgtc tgccttgcgt ggctgttttc actcaagcat gttcactgtt cctttgtacg 51660
gaataggggt tatccccaca gaccctccag gtagaaagta catctttctt ttcactaata 51720
aattagttta ttattaatag tgaaaagaaa gtacatcttt cttttcacta ataaattagt 51780
ttctatttag ggagaacata cagtgaaatc aacacatctt aagcgtacag cgcaatgagt 51840
tttgatgaat gcatacatcc acataatcag catcctaatc aagatatggg acatttccat 51900
caccccagag cccctctgcc cccttcctgt caactttcca cctccccgtc atcaaccact 51960
gctttgattt ctgtcactgt aattgaattt tgtttgttct tgagcttcat acaaatggaa 52020
tcagtcagta ctttttcgta tctgctttct tttgttcagc atatcatttt tgagatcatc 52080
tgtattgttg caggtagcaa cagttaattt aaaaaatgct agccagaggc caaggcaggc 52140
atattgcttg agtctagaag ttcgagatca gcctgggcaa catggtgaaa ccctgtctct 52200
attaaaaata caaaaactag gcggcagcag tggcacgcac ctgtaatccc agatactcag 52260
gaggctgagg tgggaggatc acttgagcct gggaggggtc aagcctgcag tgagtcatga 52320
tggtgccact gcacttccag cctgggcaac agaatgatgt gtcgcaaaac aaacaatcta 52380
tatctatata gatatagatg gttttttttt ttattttgtg aacttacata tatgtgtgta 52440
tatatatatg tgtatatata tgtgtatata tatgagttct ttatatagtc tggatttaag 52500
tcatttatca gaaatatgaa ttttttctca gtgtttggct tacctttttc attttttaaa 52560
ctgtgtttga tgagcccctt taaattttaa tgaagtctaa tttatcattt tttaagatat 52620
atgctttttg tgtctttata acatttttgc ttaccctgtg gttgctaaga tgttatcctc 52680
ctgttttctc ctggaagatt tctagtttag ccttaacatt taagtatatg agccatttca 52740
aattaagata tgaggtgtag gggtcaagat tcagttttta ttaaaatgta tgaaacaaca 52800
attattgaag tgattttttt tccttatgaa attgccatca cacctttgtc aaaaatcatt 52860
tggttttata tgtgttttaa gactctctgt tccactgatc tgcagtctgt acttaggtca 52920
atactatatt gtcttgatta aaatactgtc atgggctggg ctctatggct cttgcctgta 52980
atcccagcac cttgggaggc tgaggtggga ggatcgcttg ggcccaggag tttgaggcta 53040
cagtgactgc agcattgcat tccatcctgg gcagcagagt gagaccgtgt ctctattaaa 53100
aataataata ataggctggg tgtggtggct catgcctgta atcccagtac tttgggaggc 53160
cgaggcagaa agattgcttg agctcaggag tttgagacca gcctgggcag catagcaaaa 53220
ccccatctct actaaaaata caaaaatcag ctgggtgagg tggcatgtgc ctgtagtccc 53280
atctactggt gaggctgagg tgggaggatc gcttgagccc aggaggttga ggctacagtg 53340
agctgtgatc atgccactgc actccggcct gggtgactga gctggaccct gtctcaaaaa 53400
taataacaat aaaattcaaa aataatgaat aaatgttaaa attaaaaact aaatagcttt 53460
atggtaaatc ttgaaaacag atagcgtgag tcctctctgt cttgtttttt ccctcaagat 53520
tattttggtg gtgttctatc tccttcagag ttccatataa atccccctac cccccaaaaa 53580
agcctgttag aagttagttc agattgcact gaatcataag agagaaattt aaggaaaatt 53640
caccttaaca atattgaaac ttcaattcaa aaacacggta tatctttctc tgccttttta 53700
atgaatttct gccaggaatg tttccctgtt tttcctgcag agacattgca tatctttggt 53760
aaaatttaat tgtactttat gcttttcgat ataatacatg taatttttaa atcatccttt 53820
tcaaattatt tatataacca ggactttttt tctgatcgta cagggaaagt attaactatt 53880
tcaccactat ttcatcatga tgttagctgt aggtttttca tttgcctttt attggattga 53940
cgaagtttcc ttctattctc ttttttctaa gaatttgtgt ttgtttgttt ttatcgggaa 54000
tgtgtgttga attttgtgca gttcattttt gcctctgttg agatgtcata tggttttccg 54060
ctttatgtgg tgaattatat tgattggttt taagtgttaa accaaacttg agttcctggg 54120
ataagaacca gttataatta tgtgttattt tgacctattg ctggatattt tggctaacat 54180
tttattaagt atttttgcga ctatgtttat taagaacatt ggtctgtaat tttgtttctt 54240
tatataatat ttactagggt ttagtgttag tgttagtaat actgattata taaaatgtat 54300
tcgtggagtc ctcctgtttt ttactatttt ctgaaagaat ttatgtaaga ttttctttcc 54360
tcttaaaatt gatgaaattc cacagtgaaa tctttgggct tggagttctc tttgtgtgaa 54420
ggttctaagt ttttaaaatt taatttaaaa acattataaa gtaaaatatt cccttttttg 54480
atgtacaatt ctatgcattt taacatgtgt agagttgcat aactaccacc acaatcagga 54540
tacagaacag ttgtatcatc attgtgccaa ggattttgat actgaattca atttcttaac 54600
atatagccaa ctcttcagat tttctgttta ttcttgctat tggtaagtta tgctttctat 54660
ttttcaagaa gttttttatt tcatccaagt tgtgagattt attgacataa agtttttagt 54720
aatactttct tcttatctat ttagtgtctg taggatttat agtgatatcc ccttttccat 54780
ttttaatgat gttttcattt acttattttt gtgattagtt ttgctagatg ttaattaatt 54840
ttattaagct cttcaaagaa tgaactactg tttgctttct gttcttctca ttatttcctt 54900
ctttttccct actttggatt taattttcct tcctccttcc tttctctttt tcttttcttt 54960
tctttttttt tttttgagac agagtttcgc tctttcaccc aggctggagt tcagtggcac 55020
aatcttggct cactgcaaac tctgttccct gggttcaagt gattctcctg cctcagcctc 55080
ccaagtagct gggattacag gcatgcacca ccgtgcccag ctaatttttg tatttttagt 55140
agagacaggg tttcgccacg ttggccaggc tggtcttgaa ctcctgacct caggtgttcc 55200
acctgccttg gcctcccaaa gtgctaggat tataggcatg agacaccgtg cctggcttgc 55260
tttcctttct ctatatcact gatttgaacg tcttcttttt ttttctgttc ctaggtacac 55320
acacttttaa gattgatgta tcttcctaat aagtacaccc tttaattatt atgaaatgac 55380
cctttaactc tggcaattct ccttgtctag aaatctactg atctgaatat ggctacaaga 55440
gctgcaggct gttcagactt cagccgaggt cttgcaatga gcccttatgt tttaattgca 55500
ttgtacaaat tttgatatat acttttattg tcacttaact cagtattttg tatttccatt 55560
ttatttcctc tgggaattgt ctagtagtaa acattttaat tcacagacgt ggggaatttt 55620
taagcttccc ttttttcctt aattgctaat tacattttta tttatttatt tctcttcata 55680
gttgttgctt taaatatctc tgtgccattt tgttagatgc atgtatgttg acgattataa 55740
aatcatcttt attggttgtt ccttttgcca gcctaggatg tccctcacca tcatttataa 55800
tgcttttaac cttacattcc attttgtctg atattcagag tgctatcctg gtttttgttt 55860
ttagttttgc ttatattttc ttttttaaaa atcttttagt tttaatgtca ttgtatatgt 55920
tcattttaca cgcatcattc ttccccccca ccacatattg tgcatagctc tgtacttgtc 55980
tctgttattt gattagtgac tttataccca gttatcctta ctgtaatcat ttttattaag 56040
atttttagct tcatttaatg ttttctactt ggctttactt tttgttttgt tttgttttgc 56100
tttcttcctt tggatagatc ggattttttt tcccgaacac attttatttt attcttgtag 56160
catttatacc tttatttaaa cataaactta ggtataaaca tagtttcctt tatgtctaaa 56220
aattatcagt aatttttaag ttccccaaat gactccccca ctcataacca ttggacctct 56280
tctctctcag tctgctattt tccccagtgt tccctctact gagacttaac caccttcttt 56340
cctgcaagaa ttccccatca catggaaaat aactctcagc tgcatcaacc tctagcctgt 56400
gcaacttccc caccttgctt ggaaccggaa atgacttcta cttttagaaa gttcattctc 56460
tgggcagagt agaagataga attcattggg gtgttattga gacagagaga ccatctaggt 56520
actcttgaag aagtccagga gactttagga gggtccaggt tagagtagtg gcagtagagt 56580
gggaggactg gtggaacaac cgggaggatt tggtgttgta tttgaggagt ttgagaaaaa 56640
gagaagttga tggtgccaag tatgagtggc aaatatcaga tttcttttat tttttcctac 56700
cctattctct tccctcccaa attccatttg catgacttct taccaaggtt tggttctgcc 56760
attttaaatg aaataagaca tgtaaaacac atggtatatg tcctagtata gaaatagtaa 56820
ttaaaaaaaa tagatgctag cttccacatt tctgtctcaa gtgctgactg tatgaatggg 56880
gaggaggagc ctacagattc ctgaggagga acaacttctt tttcttggtg gcagggtggt 56940
tagaaatgta attatttcat ttcttcatct tttgaatttg agctgccaat gagacattta 57000
ggtgacagaa aattgtatat ctaagtctag gattgaaaag agatgataga gattcaatag 57060
ctgttaggaa aactgtagaa gctcgtctag cgggaggtga taaagtgaag agaagagaaa 57120
tttgaaaagc atttatggga tggattggaa gaaggaggat ccatcagaga aagttaggag 57180
gcctgaattc ttgtcccagt ctggtttatt tagccctgaa taaagcactt aaccctctca 57240
gggtcctctt tctttcttcc tttttttttt tttttttgag atggagtctt gctctgtcgc 57300
ccaggctgga gcgcaatggt gcaatctcgg ctccctgcaa cttccgcctc tgggttcaag 57360
caattctcct gcctcagtct cctgagtagc taggattaca agtgtgcact accacgcacg 57420
gaccattttt ttgtgttttt agtagagaca gggtttcacc ttgttggtca ggatggtctt 57480
gaactcctga cctcgtgatc cacttgcctc ggcctcccaa agtgctggga ttacaggcat 57540
aagccactgt gcccggccct ctcttccttt aagatctctt tctttctctc tgcctctcgt 57600
tctctttctc cattcttcat taattcaaca aagatttctt gcatacgtat tgggcgccaa 57660
attctgctct aggtattgag gctaaagcat aagataggat gtggtctttg acctctagta 57720
ctgggagcag gcaacagatt aatcattgct ctctgttaag cattatggta gggtatgttt 57780
catacctgag tcaggttgac tggaggaaag ggtgctgaga aggcctgcag agcacgtcct 57840
tcagtccaag cttttcagaa tgaggagttg ttcagacaag cttgggcaaa gaaagacaaa 57900
agaagtgcaa aatagtatta tatggatggg ctgaaggagc aataagcagt ttggtaggtc 57960
catagtgagg caggcctgac accgctagag gggctcaggg tctcgatcag gaagggccct 58020
tgtgagccaa gcagagatct tggattttat cttggatgca atgtagaccc attcaaggac 58080
tgtagggatg tgaaaagtca ggtgtgtgtt tcagtgattt cattctgtta gtgctatgca 58140
tttggcatga taagggacca ggtggtgggc aaggagacca gagaggaagc agttgtagaa 58200
atccaggtga cagaggaatg ttgaaaattc cagaaccaca gagcacctgc ttcatgctaa 58260
tcacaggtct gtgtgctgcg gcttctgcag ggaccaggac agacaggccc cttgttctca 58320
tggagtttgg agtggcaatg gaagtgacag aatggaaaga atgagcagat tggagagatg 58380
ttaataagca aggatttaga ggacttgatg agcaattaga tattggaagt gaatgagagg 58440
ggggtagtgt ctggtttgag gaagtgaatg ggcaaatgac accactcact gtgattgggg 58500
aaccaagaga ataactgagt gggaccttca gggaaaggtg cccagcctgc acttgtataa 58560
ataggtctgg atctcaggaa cggcctccgt gacttactgg atcagggaaa gaattggact 58620
atgtggatgt ttacgttact tgattttatt ctgctccatc attcagtttg ggtctgtgac 58680
tgttgagtca cctcacagag gacgaggtat ccttatatct ctttccctaa aacctagtgt 58740
ggggtgagca aaacagtagg gctattgttt gaagtaggtc tggaattctg tatcattaat 58800
ttctttgctc accctctgat ccctgccttc actttagccc tcccccaagt cccagcatag 58860
gctcactacc tggattttgg cttctgtgtg aactgctgtg ggcaatcgtg tcatattcct 58920
gtcacagaga ctctaggatg ctccagcggg tagggatttt aggatcactg ggtccaatct 58980
ctgcaattac agatgagaga ggtgaggcct gaggaggcaa gggggcctgc agagcactgg 59040
tgtagggcta cagtgtggtc gcttgattca ctggtctgtt ttgcactgtg ccccctcccc 59100
ctcgctgagt gcttagagag cagggcagga aaagttctgc acattggtgc agacgtttgg 59160
aaatgactaa gcctgtgtgt gtaactttga gacttctcgt gaaggttgtc aagaagcatt 59220
tgatcacttc agctctgagg tagggagaca gtctccttgg gcatcacact tgcattccag 59280
cagccccctt gtttggggtg ctctccaaag gctccccgta aggaattgtt tcaccccggg 59340
tgtagaatca cattgcactg cggcttcaaa ggaaaagtaa aaaagtgcag aaattaccga 59400
ccggagtgtg ggaagtactt cttgttggta agattttcaa gtgctgggga agagatgtgt 59460
tgaaaggaca tttactttca tcagcttaga gcatctgttt tttatacttt aaaaagaagc 59520
aacacctcaa attatggcag tccctgggca agtaagcact tgagattttg atctgtacag 59580
attcttagag ggagcgcctc gcaggagctg ttagtagtga tttgtagcac ttaactgatt 59640
ctgtagaccg acagtcaatc ttggggggaa agggggttca gaggcaatga tagttaagga 59700
actgctccgt aaaacagcaa ataagccatt gctcttgcac ccgagtagaa atggaaactg 59760
tacttagcag gctctggaga ccaaattaga taggaaatga aaataaattc catgtttttt 59820
atttttaact cagtgcgcac ctccaaaaca ttcgtacagt gtgggctcca tgacgtgttt 59880
tgcctgctct cttatacaga tttaagtttt taaatggtag ttagagacac tcaacataaa 59940
agctgctgct ttaaccgttg ttgttattgc tttgtttttt tgagatggaa tctcgctctt 60000
gttgcctgca ctggagtgca gtggtgtgat ctcagctcac tgcaacctcc accccccagg 60060
ttcaagcaat tctcctggct caggctcccg ggtagctggg attacaggcg tgcgccatca 60120
cacccagcta gttttgtatt tttagtagag acggggtttc actatgttgg ccagattggt 60180
ctcgaactcc tgacctcagg tgatccaccc gcctcggcct cccaaagtgc cgggattaca 60240
gtcgtgagcc actgtgccca acccacttta accattttta aatatgcatt tcagtggcat 60300
taagtacatt caccatagat gtactattta ttataggcac agtttcctaa actgagtaaa 60360
gaaaggaaac atttaccccc acagcccagt atagtcattg ttaaaattaa gatgttagtc 60420
tccaagtctt ttgtttacat gattttgttc aaacctagtt gcaatacttt tcatagaggt 60480
tataaagaga aatatagagt tataaaggaa tttttttaaa attatacttt aagttttagg 60540
gtagatgtgc acaacttgca ggtttgttac atatgtatac atgtgccatg ttgttgtact 60600
gcacccatta aatcgtcatt tacattaggt atatctccta atgctatccc tcccccttcc 60660
ccccacccca caacaggccc tggggtgtgg tgttcccctt cctgtgccca agtgttctca 60720
ttgttcaatt cccacctatg agtgagaaca tgcggtgttt ggttttttgt ccttgcgata 60780
gtttgctgag aatgatggtt tccagcttca tccatgtccc tacaaaggac atgaactcat 60840
cattttttat ggctgcatag tattccctgg tgtgtatgtg ccacattttc ttaatgcagt 60900
ttatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat agtgccgcaa 60960
taaacatacg tgtgcatgtg tctttatagc agcatgattt atactccttt tggtatatac 61020
ccagtaatgg gatggctggg tcaaatggta tttctagttc tagatccctg aggaatcgcc 61080
acactgactt ccacaatggt tgaactagtt tacagtccca caaacagtgt aaaaatgttc 61140
ctatgtctcc acatcctctc cagcacctgt tgtttcctga ctttttaatg attgccattc 61200
taactggtgt gagatggtat gtcattgtgg ttttgatttg catttctctg atggccagtg 61260
atgatgagca ttttttgtct tttggctgca taaatgtctt cttttgagaa gtgtctattc 61320
atatccttcg cccacttttt gatggggttg tttgtttttt tcttgtaaat ttgtttgagt 61380
tctttgtaga ttctggatat tagccctttg tccgatgagt agattgcaaa aattttctcc 61440
cattctgtag gttgcctgtt cactccgatg gtagtttctt tggctgtgca gaagctcttt 61500
agtttaatta gatcccattt gacaattttg gcttttgttg ccattgcttt tggtgtttta 61560
gacatgaagt cgttgcccat gcctatgtcc tgaatggtat tgcctaggtt ttcttctagg 61620
gtttttatgg ttttaggtct aacatttaag tctttaatcc atcttgaatt aatttttgta 61680
taaggtgtaa ggaaggggtt cagtttcggc tttctacata tggctagcca gttttcccag 61740
caccatttat taaataggga atcctttccc catttcttgt ttttgtcagg tttgtcaaag 61800
atcggatagt tgtagatgtg tggcattatt tctgagggct ctgttctgtt ccattggtct 61860
atatctctgt tttggtacca gtaccatgct gttttgatta ctgtagcctt gtagtatagt 61920
ttgaagtcag gtagtgtgat gcctccagct ttgttctttt ggcttaggat tgacttggca 61980
atgtgggctc ttttttggtt ccatatgaac tttaaagtag ttttttccaa ttctgtgaag 62040
aaagtcattg gtagcttgat ggggatggca ttgaatctat aaattacctt gggcagtatg 62100
gccattttga cgatattgct tcttcctttc catgagcatg gaatgttctt ccatttgttt 62160
gtatcctctt ttatttcgtt gagcagtggt ttgtagttct ccttgaaggg gttcttcaca 62220
tcccttgtaa gttggattcc taggtatttt attctctttg aagcagttgt gaataggagg 62280
tcactcatga tttggctctc tgtttgtctg ttagtggtgt ataagaatgc ttgtgatttt 62340
tgcacattga ttttgtatcc tcagactttg ctgacgttgc ttatcagctt aaggagattt 62400
gggctgagac aatggggttt tctagatata tgatcatgtc atctgcaaac agggacaatt 62460
tgacttcctc ttttcctaat tgaatactct ttatttcctt ctcctgcctg attgccctgg 62520
ccagaacttc caacactatg ttgaatagga gtggtgagag agggcatccc tgtcttgtgt 62580
gtaaaggaat ttaaagacag cctactcctt ctccccttct ctgccccgtt tatagatgaa 62640
gaagtgaatg gccaaaaggg ttaatggctt gcttagctgg acagtggcca tgcttgtccc 62700
agagcatagg tgctccatcg cctgagcgcc attccctggg ctagtctgtt gttagtttca 62760
acatgtgtca taaaaaattc attggtggtt tatttttagg gtaatcttct tttttcctct 62820
gtctctttct ttgtgtagtt tctgtatcta aactttttta atggcatctt caaataggaa 62880
cttgttttaa accagaacgt cacaacacgt atgccattcc tagggtttat caccctgatg 62940
ccaacatccc ctcccaaacc tcgcttctgt tcagatatta ccatacccag gaggtcgctg 63000
ctttttgttt tttttttttc catttgtttt gctggttcac ggttcattcc agagtttaaa 63060
ggtgctaaaa ccaaagttta aaggtgatag taattgtccc atgttgggtt tttagctggt 63120
ttctttttct tcttaagatc tgttttccac ttagaaatga ggtgaaaact cacagaagca 63180
aagcctagca gctaaaagca gcacgtctgc ttaccacgtt acaccctccg ggctgatctg 63240
cagcccagat cccctttcca tcctctacct agctcctcaa ttcccatcgg tgagcagttt 63300
tcacctcctc ctgcccacgt ttggaggtct gtgggtggcg gttaggaagc caaaggaggc 63360
tgaagctggg gtatattgtt tgggtcggcc atggcaaccg cggcaggaaa aggaacagga 63420
ctagttttgt gctgctctgt aaatggccag gattcagcag ctatctcagg acttctgctt 63480
ggccccagac aatctgatct cctggtaagg ttattaaact tggctctcct cttccaccct 63540
cctttgatca tgttgtcagg cagcgagtag gaatggccgt aaggggtcgg ctggtggggg 63600
ttgcagagca cagcaagata tgcaccagca gaaacataag aacaggggca gaggcaaatc 63660
agggactgtg ttcttatctt ttctgcaccc cagatgcaga gaagtacatc cccaagtcct 63720
tgccaatact attcttcaag agttgagcac cttgctccaa agagcctgtc cagatcgcca 63780
gtttgaccag catggaggag aacaaggaag ggccggtcct ggaagacccc aggatttttt 63840
taattgggaa agcattattt gagttttctc tgctgcaaag cacaaactgc ctaccacatg 63900
tgtttcataa aaatgtcact gaaaaggaga gtgagaatac agagtaagct tccatggctt 63960
aataatagtt tattttgtga cttggaatag cttttctttt cattcagcgg atcattttag 64020
gtgtcattca gtttatttta agtagtgtgt ttcatcctga gcggattaag aattttattt 64080
tttaaaactc tgtactgtgt tgcttcctac tgggaaattt acattaaaaa aatgttcgtg 64140
agcaaaatct atttggtcaa aaagaatggc ccacgattat cactgaattt gggatgtttt 64200
tcttctaagg gacacagttg attcttactc agaatcatgc gagtctgaca tttcatttgg 64260
ggaagtctga ggaagttggt gaggtcttac gttaataaaa acaagtgctt ctttttcttc 64320
ttatcacctt tcagtgtctg ctctgctggc tcatgcagtg taggttggct tacctctccc 64380
tggaagtcac attgtccttc agaactcttt ttactatgac ccacaaacag ttttcagacc 64440
tcactctgat gagtcaaagg taaagctgtg aataaacaga tggtgaaaca acatttgcag 64500
ttctctgact tcagtcctcc ctgaaaccca cttggaatct agctctgaat tcagccggac 64560
atgtttgttc ttcccttttc ccatcctcac ctactcctaa ccttcagtgt tctctttacc 64620
ttttattttt atttttgtca ttttagtagt aaatgacagg gacatagtta ctcaatttgt 64680
aaaacattga atggtgaggt caaagattct atgacgagct tgagatttct aacaggttca 64740
gatggatgac agcaacattt tgctggctta attttggagc tgtttttgta ggttttgaaa 64800
tgcagtttaa tagtgagtaa tagagaagtt tctttctgcc gtggagctac tgaacccttg 64860
aaagtaacat gctggcacat acagatgaac tgtagcccca catttattcc ttgcttagtg 64920
gtaagctgta cactgaacaa tagaaaacaa aaggctattt ttctttggaa gagcagatac 64980
tgatttctgg acaaagttta tgttgtacaa gttaaacatt ttttattctt ttctggttag 65040
attttctgcc ttttaaaaaa ttagcttagt tgaaaaagca ggtattatta aatacagttt 65100
attttattga attggacgga caatcgtaga attttaaagc ttaaatggct ttaattgaac 65160
ctaatgttct aattttacag aggaaacatt tgaggcttag tgcggttaaa tgaccactcc 65220
tacaacacac agcctgtttg tttgatggct gaggctgaaa accagactcc agactcctaa 65280
tttaatgctt ttccttcatt ggtcatgtct ttttagcttc agtgaagatc tttttttttt 65340
tttttttttt aatttttgag gttatttaaa aaatactttg ccttgaaaat ttaacatttc 65400
cacttaatca ttctcatact tcaagaacag tttctctgtt aactttctgt ttaacttctt 65460
aaaccataca ctgtggaaat tatctgtcta tatgctgaac agtctttaat gactgcatgt 65520
gtgccgtagc tgttgagatg ttttaatcca ctttagcaaa aggtttattt gtttaagaaa 65580
agtgcagtgt tgtattaagt ctaagcttag aacaatgaag catcatctcc cagctactgg 65640
gagtgagaat gggaggggca gggagtggtt ggtactatga gctgctctaa agaaaattca 65700
tttcagcttc ctcacatgtt aatacaatca tatttcagtg aagcccttct tcagcaacag 65760
tcactaatga tagagtgatg tgtttagact tgaaggttct ttaggtgctg tttaaatgaa 65820
taatgagtgt agttaattca caatacaggt gaaaagttaa ccacagagta gtggcactgc 65880
tctttctttc cccgtcacct ctgtgcatga tctcttgctg cgccattaga agggatgatt 65940
agaatgggca aatattccct cccggtgctc ctggcaatag gaaagcactg tgggtgagat 66000
atgtctgcag agcagtggta tagtttcagg aagggacctc attctgctct ctggggcaaa 66060
gcttccgggt gcctgagtgg gcctcttcct agtcgatggg gcagcttgat ggggtggcta 66120
tttattggtg aaaacagtat ccatgtccca ttggttattg ggacttgatt cctaatttga 66180
acttaggtgc tgtgaagaga cttatgtaac gctgtttaat ccatgtttgg ctttgttaga 66240
agagtttaaa atactcagaa ggaagaaatg tttggttcct ttgaaaaggc agactgttca 66300
tttagctagg gagagcctca ccaaatgagt caattaaaaa catttgggga ttaagcccag 66360
tgagagtgct gtttttatat gagacatgaa gagggtgggg gaggggcggg tggaactatg 66420
gggaaacagc ataggaaaaa aaagatcttt agaaaaggaa aaagttagcc ttagctcttc 66480
agagagcact gggtgggaaa aaggatttaa gtggaaagaa gaaaagccct agagattttt 66540
gtaccaaaaa aaaaagagtg ctgttaaaaa gatgaatcaa cagctatatt ctaaatggcg 66600
tctccttaac tgggatttga agggaagaga aggcctgagt agagtcttag acaagtccaa 66660
gggtaaaaaa gcaaacagat agttgaagaa gtggaaatta taagtttggt ggcaaaaact 66720
tacttgtaat tagaattttt gtgtccttaa tacttgttgt tatgctgata tgataatatg 66780
ctaataatat gctaaggaat tttcccaatt cataatctaa agcaaaatta actaatatat 66840
gttctgttat ggaaattcac ctaaattgca ccagcaggtg tattcatccc gctaatacta 66900
acactctgtt actagctcca ctgtggcgtt tccactgtaa cgtggtggtg ttggtgctac 66960
tcattgtgac agtgtggtgt cccaaagagt gagcaagcct cgccaacgct tccttaaaac 67020
tcttactgat ggaactacca tgtttatata gcaagaatat tagagaaaga agagtcgaga 67080
aaggattcca caacacacat ctagtctttt cctctcttag cttttagggt caacactacc 67140
tttctcttgg aaatgagaag gggagaaaac cttttccact attctgaaaa gagggtttta 67200
aaaattctct caggtcgcct aagctggagg ggctttatga cagcactaac cagtaggtca 67260
aaaaggaaat ttattttttc ccatcatagg ttcctctcta cacagagaat gcaaaaccgt 67320
aattcttaag agttcctcaa tgattattca cttttgttct tacttccata tttctctagt 67380
aaagatttaa atatttaatt ttgtagactc ctgaaataac tgcttccaga tagtatattt 67440
actcagaata ttatttaaat gcattaatgc tgacattgtt agaaagggga gaaaactcaa 67500
cattttccgg cagaaatcat tgtaaaatgt attataaaat ttcctccctt cctaagtaga 67560
gtgctactat atagtgaata taatttaact ttttttcttg gagacttatt gtcatttctg 67620
tgaagttatt acctcgacat agtagcgtcc tgatgcctca aaagctcata attcttctcg 67680
atgccacagc ctctgtccta tctacttgtc ttggttgtca tgtcttcaat ctcctttcat 67740
atttgcctat atctgtaaac ttaagagaaa ccagataatc aatctgataa aatcactaag 67800
ctgaatcata tacattaatt ctcattccta gctctctcca cctagccagt gtggcctgag 67860
gcattcatag ccatgttctg agtggtgaag gctaagagag cccaggagag ctgtccaggg 67920
ttaaataaga cattaatata taaagtaagg actgtcggta tacgtgatat ttatatgtta 67980
tcatattaca ttttatttat ttatttattc atttatttat ttgtatatat agagagagaa 68040
acagagtctc actctgttgc ccaggccaga gggtagtggt gccatcatag ctcactgtag 68100
tgtcgaactc ctgggctcca gtgatcctcc cgcctcagcc tgctgagtag ctaggactac 68160
agacttgtgc gaccacactt attttttgtt tttaatttat tttttgtaaa gacagggtct 68220
cattccattg cccaggctgc atttttaagt ttagtaactg cccaaatgga cattgggtaa 68280
aataaaaata aatacagtca cttctcttct taaatcattc acctctcaag atgaaggtac 68340
taataggaca ttttctagaa cttcagtgtt aaccacagca aggaggaaag acaggcctgt 68400
tagatgtaga ctaagaactt cagaagctgt ctccgtccta ggctgggccc agggctctag 68460
aattgtccca cacacctggt gggcttgctt gggtacttgg gtggtacctg ggagatgatg 68520
acctgttcat cttcagcttc tgttattcca ggaaacagag gtagtcatct ggatactaca 68580
ggtttgccag ctctgctact tctgcttcta ctgcaggagg aggagctatg gaatttttat 68640
gcatgcatca aaacactgac ttggctcata agactgctta aaagacagag tgataaatta 68700
cgccttgttt ctcatgaaac agatttttcc caaaagtaga aatactaatt tataatgtat 68760
ccttttcaga aagattgtaa gtctaagttt ctcagagaaa cagtgtatgt gatggcagga 68820
ccccagtaaa gtccaaaata tcccataatg gccttaggac catgcccatc atagtctcca 68880
tagagccatg gtccccaaga gccatggtgc ccaagagcca ccacttcagt gggtggtagg 68940
tggttgtgaa gaatggtcac tgtggttcac agaataacag tgacaattgt gaatagaagc 69000
cagtcattac ctaactgata aaatgagtga ggctagcaaa gggcctgaca ggaagtgaaa 69060
tcacttactg aagtggtggt agagtacgca accaagaact aagaacagga gggaagttaa 69120
ccctagggag agttcgactc cacttgagga ggaacattct ggcaatcagg actgtctaaa 69180
aatggaacaa gctgattgat ttagcagtga aacctctgtc actggagatg ttcaaacaga 69240
ggtagtagga ccctcttatc aggaattctc cagagaggag atgtgagttg gatagaaggt 69300
tattgtagac gaccacttgt ttctctctca gctctgaaat gtagtcctta aggctgacgt 69360
gtgtttccca gtttctaatc ggaaaagata acataatcta cagtgttgaa ataatttaaa 69420
caaagtaaat aactgtgctt ttacaaccat aatacggttt agcctttcat tattttgtta 69480
cgttcctcat taacatagac ataatttctt ttaaagaagg gacaattgtg acgagcctgg 69540
gcaacatggt gaaaccccac ctccactaaa atacaaaaaa ttagctgggc gtggtggcac 69600
acacctgtaa tcccagctac ttgggaggct gaggcaggag agttgctaga accaggaggc 69660
ggcggagctt gcagtgagcc aagatcacac cactgcactc cagcctggcg acagagcgag 69720
actccgtctc ttaaaaaaaa aaaaaaaaga aaaaaaaaaa agaagtgaca aaacttaccc 69780
agtaaactaa atgttaattt cctcttctca ggagcataat actaacttac tcctctgttt 69840
ttatattttt gagtactgat aatcggatag tgatatattt gtgttatttt ttgttcaaac 69900
aattgaattc attcttagca agaacaaaag tctatttgaa acatgtaggc atcttaggta 69960
gattaaattt ttcattgttt caagttttga cttttgtatt tctgcacatt agtgatcctt 70020
gaagattagg caaggccaag ttcttttgac ttttataatt agtgtgtcgg aatcccagtt 70080
tttcctaccc tagggtggac tgtatttttt acaattaact ctgtgaaggg tgactggggg 70140
tggactggtg aggagaggct tccagttacc agagagcctg tgacttactc tctgtgcttt 70200
tcctaggtca ccaattttca aagaatttga gtataattaa atacacttca taataaacta 70260
ggctgaacat aatttaatct ttccctgaag gtacttcaga gtcttggagt gctttagggc 70320
catgatgagc atcaattatg ttctcacggt gggtgtgcag aaggaggtag ttaatagagt 70380
tctgtttgat caagtcctgg gtgactggac atgtgttctg ttatgattag cagttcagtg 70440
tccaggtttt ggaactgatg cttagtatta aattctcagg caggagagaa tggaatagag 70500
attgacctct ttggctttga gaggctgaaa gttgatgacg ataattcaca tgtacatggt 70560
atatatagca ctttttagct tccaaagccc tttcacatac cttgtcttcc attgcttgtt 70620
tcttgtgatg ttctggaaag gaagcaaggc cgctggtatc ccatttttac agatgaggac 70680
agtggagctc aggaagcttg agggacttgc ctaagctcat acagtagatc aatggcggag 70740
accactggac ttcaaattca gtgctctttt tagtatttca aaggatacta aacatttgct 70800
cacatctctg atgttctttg tgctgtatgt gtagtaactc atttaatcct cacagtggcc 70860
ctgttagtag gtagatatca gttcttctgg tactattacg attctcatct tcagagctga 70920
ggccactgag aggcacagag aagttagggc atgcactagt gagtggcgga gctgaaatct 70980
gaacttagag ctttggctcc agagcccatg cactccacca ttatgctaca tggctactca 71040
gtgtacagat acactgagct taagtagagg agaaagctta tctatccata tcttcccatc 71100
tgcaaagacc tctgcctgta tgggaggtct gggctcgttc tgactaaggt tttgaaccca 71160
gatctgccaa tttgagatct tgggcccatt acttagcctg agcttcagtt tccacatctc 71220
taaagtgaaa atatagaaca tggaatgtac ctgtaagaac acaatggaat acaggtaaag 71280
tgcccagcac actgcttatt ccttagcctt catgttttag aaagtggttg ctattgtttt 71340
tgttgttggt ggtggcggta gtggtcttct tcttattatt atttatatat ttacaatggc 71400
caaaattata tgaaatgttt tccaaaaatt aggtatttgt acccttcata tgaatgtgtg 71460
tgttaattgg gtataattgt ctttcttgag tctttaaaat agacaaatct tttgattaca 71520
tttgttaata ttattgtacc tacctatatc tgacttgact tacaatttta cttcattaaa 71580
tacatagcaa gtcatctgag aacccaaagt aatcatacag attacttgcc atatagttaa 71640
tttgtgactg tgatatggct gctaaggtag aggtttgaat ttaaaagcac aaagaaaaat 71700
gtttacttca atggttacaa atagattaat catataaagt acatatttgc agagtctcgc 71760
tcagtcgccc aggctggagt gcagtggcat gatctcggct cactgcaacc tccgcctccc 71820
aggttcaagc aattctactg tctcagcctc ctgagtagct gggactacag gtgcgtgcca 71880
ccacgcccgg tgtattttta gtagagatga ggtttcacca tattggccag gctggtctcg 71940
aactcctgat gtcaggtgat ctgcccgcct cggcctccca aagtgctggg attacaggct 72000
tgagccacca cacccggcct attctaaggc ttgttctaag gctcacagat ggcaccttct 72060
ctgtgtatcc tcacatggtg gaagaggcaa agcagttcct gggggagttc tttgataaag 72120
gtgctaattc cattcaagag ggcacctccc aagggctcca ctccctaata ctatcacgtg 72180
gggagttagg attcgacatg tgaattttgg aggcacacag acattcaggc caaggcataa 72240
acagtgacca cttttgttct gtctgtccac acactgccta gagcttccat ttatttcaac 72300
tacatttgct tttttcttat ttatctgttc agagtatctt ctcagtggct atttatttac 72360
caccctttaa catgttttct tgacattgta cttcagcctg tatatgcttt gcaactcagg 72420
aactatgctg gcttaactaa tagtacctac ttaacaggtg aaactgacag taacagctta 72480
ataggtgctt tccattttta acatacctca gctttttata aatacaaaaa actctcaatc 72540
ttttaatgtg gttttaaatt ttaaacaggt cttctttcat tttcctttac agaaaactgt 72600
aatactgcat atgcattttc aaactatgca tatttcttct tcattccatg tggaagtttt 72660
tattcagcct ttcagtaaat tttacttagc ttgtcccatg gatgccgtag gtgtaaggaa 72720
tatgatagtg aacaagacag acagagctcc tcccctcagg gagctttgcc atgatacacg 72780
atgatgacaa tgataaaagg agcaaataat gatttgggac ctgattccaa agggatattt 72840
ctgcgacact tacaatgaaa ttccaacctg gcaccatctt tttcactgca gaatgcatga 72900
aggtggttgc atcatgtcat ttcgacatgc atttaaatgt aatgaaaggc acaagtagtg 72960
attgcaaaca ctacaataag ttgcttgttg actctcttac tgtcttcctt cttatctccc 73020
tttcttcctt tgtctcattc tcagttttca gagcttagtc attatttcgt aatcctctcc 73080
taaaatgaaa tctggggctc taaggacagg aggcacaggt tgtgtttgaa cagcatcatc 73140
gtgctttatg aaggggattg gaggggagat tctgccccac agtatggtca ggtctcgctc 73200
caggcagcac tgactacatt ggtgctggtt gggtaactgt ggctcggcag gtcactctcc 73260
ctctttccac ctccgttttc tcattattag tagaagtcga aatagcatgg ttttctaagg 73320
cctctgccaa tctacaattc tgtgattcat atgttcctaa acacttgagt tactttttct 73380
caataaatgg aaatatattt tccaatgagg ctggaaatac attttccaat tatcctctcc 73440
cctggtttat aacatatcat caatgtgttg ggacttctaa cactgcttct gctgtaagcc 73500
catcaagagg ttaattacct ttgaagaatg aggaactgct ggaaaagaac tgtaaaacct 73560
tcaagagaac tttggagtta atccctctgg taataggaat caatgtcact cacacatcta 73620
gttgccagtg gaggaggaat aacagcactg ggccaagtag acttgaagga aggcaggttg 73680
ctgatagagt ggagagctga agattctgaa tcaagctcat catgactctc ttcctcctct 73740
ttgaggctac ccaatcagag caaaaacagt attttaaaaa acctcaactg gatgagcctg 73800
atgcagtggt gtgctcatgc agtcccagcc aaagggtcac ttgagcagag gagttcaagg 73860
ccaacttggg caacatagtg agaccccgtc tctaagacaa ataataaaca tcaaaattaa 73920
aattaaaaaa aacccaaccc agtgttccct tcagaatcct gagtggtttg tttcatcttc 73980
ctctattctg gcttgtgtca tcttcctctc ttgtaatgga taaaaactcc aaatgaagac 74040
aaaaatgagg aatttgtcaa aaaaattgaa ttgccaacaa aagccatctt tggttgatca 74100
aacggtacag acgtttcagt tagacaagag ggctaagttt ctgagaccca ttgtacagga 74160
ttattaatat tattcatttt tagccctcat aataaggtat tataaatgtc aagattgcta 74220
aaagaatacg tttttaaatg tcttcattat aaaaaataag tatgtgaggt gatggacata 74280
ttaatcagct taatataatc attttatagt atatgtagct atatcaaaac atcacattat 74340
aacccataac tacatgcaat tattatttgt caattaaaaa tacaaatcta ggccaaggtg 74400
ggaggatccc ttgagcccag gagtttgaca gcagcttggg caacataggg agactccatc 74460
tctacaaaaa aaaaaaaaag aaaaaaaaaa gaaaaaaaaa ggaaggaaaa aaaagaaaaa 74520
attgactggg tgtggtggct cttgcctgta gtctcagctg ctcgggagct gaggtgggag 74580
gatcccatgg gcccaggagt ttgtggctgt agtgagctat gatcatgcca ctgcgctcta 74640
gcctgagcaa gagagtgata ccctgtctca aaagtaaaaa cttacaacaa tataaaaaat 74700
aaaaatttaa attataaaaa gccatcttct ttcccactcc ttcccatttt gatacaacag 74760
tcccagaccc cagacttgct ttcctcatga gtcatgcaga ctcaagtatt gcagttccaa 74820
aacactgcct gactcaccag ctccatccaa aagagtatgt attgtcttca tatgccagat 74880
aggaaattcc tgctgcatat aggaaaagca gtgtgtttaa atacatggac acacacacac 74940
atacacacac acagagtaca catatacaca tctgcatata cacgtacaca tatgcgcaca 75000
tattcatact atatatgtac atacacatgc aatacacatg tatacacacc acacacacac 75060
atacacacac atgcatctcc aagtctattt ccatgctttt tttcagtaaa gcacctagac 75120
aaaggagaga gatgtctaat caggttttgg tggttgtcag ggatatcata aatgagaatc 75180
tcaagttact aaacttgatt tcacaaaata gtttattggt agttttagaa tggcattgca 75240
ttttaggcag ccccaattgt aaataagtga gccgggtaaa agcagattgg atgtcaccca 75300
gaatattttc tggaaagggg acatacacaa aattctctct ttgcacaatt accctgtttt 75360
gggtttgcaa tattatgttg agcaaggctg gctattttcc accaacagga tgttacagct 75420
tgtcaaaagt tattcaacct atagtgttaa gcaggtactt catcattact gaatttggtt 75480
gatgctctat ggagaaagcc aaagttagga gttttgtctg tcattgaggt agagaccctc 75540
aactagggaa gctttgaact gttcatccag ctggtattct gtaccacctt gcctctggag 75600
ttgagcttag aaccctactt ccattttttc tgtcacttca gggctgtttc aactattgtt 75660
tcttcattta cttatatcaa gtgtgttttc tcaattcata agcatgggag accccaagag 75720
acagatatcg cattagtcct tttttgtttg tttagcagga aggtttttaa gtaaagctcc 75780
taaatgatat gtctcattct catggaaatt catcaatatt gttttactgt ctcctatctg 75840
gttacttttt attttaggta accactgtga tacaatatac acaagtccct ggatcatgaa 75900
aataaattga agagctaatg ttaatagtaa gttctcaacc aggggttatg ctggaaccca 75960
ggatacataa cccacaggag ggccctccgt gaactcagtt ttcatggaat tgtcccatac 76020
cttcacaggt agaagcatgg ctatgttaaa agtggccaat gaaagtatag tttctttatg 76080
ccttatactt tgtttggtga ggatttctgc cagaggtgtt tgtttccttt agttttctgg 76140
ttgctatgat tttatacagc tttggtgacc tctatgagta ccagataaag ttaggtatga 76200
taaaggcaca aaaagaccgt agaagccatt tgtattctaa atataaatat acagactaaa 76260
tttgtatgca tttgtgtctt cattcttcac ggtgctgtat cctccgtgtg tgtgtgtgtg 76320
tgtgtgtgtg tgtgtgtgtg tgtatttctt ctttgattcc aggctgctta tacgaaaatg 76380
ctgattcata gtgtcactgt cttttctttt tcctgcgaaa ttctaaatcc gtttctaaac 76440
tttttctaca actctgagtt taatctctct aaagtttttt tttttccctc ttgcggacac 76500
aaggcacttt gctttgttta tgctaataaa tgtcagacta gcccccaaaa attagaagaa 76560
atgccagtaa tttcaaaggg ctcttgagca tgattttttt tcctgtttct taatacattg 76620
tacttttcag agtttaagtt taggtgcatg taggtggtat tagaagattc ttagatttta 76680
ttggtagcat ccagacaatc ttgtcatcac ccgatatata tcacctctat gtggtagacc 76740
cttgtggaaa ttttctcatc acgaaagtcg aaagtttaat tttggagagg aagaggtttt 76800
tcagatacat taaataggtt ttgctacaat aaggtgagat ggtactttca attgagcatt 76860
tctcatatac tagcaagcag acagcttggc ctcctggttg taattacatg ccaatggctt 76920
ggtgcttttt attttagaag ttgagttcat cctgaattct ctgagcatat ggagtagtgc 76980
actctgattg ttcccattaa gattgtaatt ccatccaagg cttatagtgt cattgtaaac 77040
actagatgga attacagccc catgcacatt ttggaagact gcattattca ttgaaatact 77100
ttataaagtt aaataatttt gtaaatatgc tccaagttca tgggacttag atagaaacat 77160
aatcctggcc acaaaggagg ttctcagtaa atatttcttg tttatttgat ggactttcct 77220
tatatcttta aataaactgt atttttaaaa agtgtagaga ggttatactt aaatatttgt 77280
aggactttaa aagatcttgc cttgaaatgc tcttacggtt tcttgctttt cattgatgga 77340
aaaattgact tcccatatga atatgttatt taatcttttc tgtttctagc ctagagagaa 77400
atactgagta gctcgagtgg tcaagaatct ttattttagg gacatccgca tgtcctaagt 77460
aattcccttc tatataaata tctcttttcg gcataatgtg ttgcatgcct tcaaggtgga 77520
ccactatgag gtgaataatt acacaacggg aagcctggct gtctcgtgga atattggatg 77580
gatggctttc ttattggtct taattaggac agtgttgtta agataattca ctaattcaca 77640
gtgcgttatc agatttgaaa tgacctcttt tttttatact acttcggaag tgtatgtata 77700
ccttttagga aagacctgga aggataagtt gtatatttta gtatctgata tggttttaaa 77760
atttaagact ctgtgttatg tatgttttgg gatgactata aataatctgt gtaacaaggt 77820
attaccaaaa accttattgc ctttgccacc atgcactgca aaatatagta tcaggaagcg 77880
aaaagacaat gcattttgag taatttttag aatttgcatt tttgtgaatt gacatgtatg 77940
tatggaggac ttttcaaaaa aaacagaact tttcattaag aatattcggt attaagatat 78000
tgttttaaat gtcagatatt tttaaaatat atgaaaccat attaatcacg tattacttat 78060
actttttgtc cctggaaata ttccattttt aagaacagag ataacaaata aatataccag 78120
taaagctaaa gtcagtgctt tctgctctta aaataattta ttgaacgata aaatgaatgt 78180
ctttgctttg tgaaattata tttttgttta ggacttgata atgcttagag aacattttag 78240
tttttacagt ttaaagaatg aataatgact ggttcctctg ctccctgatt tgtttccatg 78300
tagatagtac ttcattttta ttacctgtaa acatgtgtta gctttatcaa ttaggctcaa 78360
ttgaatgaag cataaccccc tgaaaggcct tgccagtaaa ataataatag taataataat 78420
attcttttct tcagattcta gcagggagta ctgctggctt ttatgtaaga agtcaacttt 78480
aaaagtgttt ttgtgtgcgt gtggtgtggg tgcagcagca atattgtgta ttcctttcaa 78540
atcaagatgc ctcatagtct gtgggcgggg gaactcccta agatgccctc actagttact 78600
cattcatttg ttcctcccca gaaagggaaa acccaatgct ccacactcca cttattctga 78660
ataatggggg cggggaggtg gtggcgtgag gatgtcagtg tcattgggca aaagccttca 78720
tttttaaagt ttagcaaaat gcagttttat tgctttatga tcagtgtgta ttacaagcta 78780
atatacaaat ggcattagtg atcaaagtgg gatactgatg tggcaaaaat ttacaataca 78840
cttaacagat tgacctgaca taacagtgaa agcatttgaa ttccttccca catagtaagt 78900
aacaagtaat ttctggagcc agaagtggga gggtgtgtgt gtatgtgtgt gtgcatgtac 78960
gtatgtgtgt gtgtgtgtgt tgtctgtaga agttaacaaa tatgttagtt cattgaccat 79020
ttctttcgtt gtcctaaaga aaatttcact cacttgtgct tctgatttgt ttcccgtgaa 79080
gtctcttatc actcttagaa catgaaggcg aattaatgaa gaatccttaa ttcttcaaaa 79140
aaaaaaaacc agccctaatt taagaaagga gacatttaac ttgctaataa gatcctaaaa 79200
ttttataggt tatataatac attcaaggaa attgaattat atattcatta agaatacatt 79260
atctctatta gcagagagta aatgattgag gttttactga acgctaaatg ctcagaaagt 79320
aaatgcaaag accatcactg gttgagcacg ctgggaactg ggtggaagtc ttaggcctgt 79380
cattaactgt tgtgcggcct ttggcaaata accgaagttc tctgagcctt aggaaaatga 79440
ggaagttggg ttatataagt ggttttcaaa tgtggcttca gaaaaccctg gagagccact 79500
gcactccagc ctgggcgaca gagtgagaca ggcctctgtg gaattagcca agggtttggg 79560
taaggggtgg ggctgagacc tgagaatctt tatgttacaa cagctattag gcaatgtcag 79620
ttcacaggac cactaaatca aacaatcctt cagaccactt ccgactctca agtttcaata 79680
agtccctaga aaacatcatc cttggtccac aggaagcaat ccaataagga acttggtctc 79740
ccataaagaa tccaataaag aaaactttaa aatgagagga gggttatgga tttgatcatc 79800
tccaaggacc cctgtcaagc aagtctaaga tctttccaaa ggagatctga gaaatatgtc 79860
tgtatcccaa gaaggtttga caatagtccc tgaagtttgg gggatgactt ctagatatcc 79920
ctgtgccttc aagcgtgatc atgggctgga tttgttggcc ccatggtctg cctctgagtc 79980
acagacaaat gatgaaaaaa agaacaattt tctgtcagca tgccagacca agggaggggc 80040
caggagaaga accgtgaacc atgaactgtg ccactgctgg aggcactgac agctccttgg 80100
caccagatgt gtgacctcaa cccctgcagc ttgggcacag ataatatctc agggcagggg 80160
atgaggaata gaggaagaag ggaaagttgc agggatcctg gagtgttaat acccatggtg 80220
gcggcagagc aatttgccag gaagaaaact ctctggttaa ccctccggca ctagttgcca 80280
agcatgtttg tactagaatg gagttcaaag ttacaaacag agcactgtct gtttttaagg 80340
actcatatga aaggtttgct tgtcctaagc ctgaatccaa gagtctgtct gtcataaaca 80400
ctttcaggta gcccaaaaat cccttcaatg tgatctccag aataggggaa gacaaaggac 80460
tcaggtcttc agctgtctga tgaggagtga gaaatttttc taatgaacat ctctggctta 80520
tggatattaa ggagagttca gtgtcaaaag tttctgcagc gtagttaaca gaggtggaaa 80580
gttgaaataa ccttaaaggc actgaagctg agaaactgcc ctctttatcc taacagccac 80640
agttagtttt ggaacactgt ccatggagaa gctcagggct gtcaatttag aaagcagctg 80700
tgtgctggcc cattgggcac catctttctc tcataggttg ttctagtcca aggtgaagaa 80760
agctacattt tgctctaagc tagactgaca tatggacttc tagatttgaa ccctaaacac 80820
aggaggaagt gattgattgt attacaaaaa gaatcttctt tggtaaataa ctattttttt 80880
ttttaatggc cagatgggag aaagcaaaag atgccttttc gtggtgtttt ggaaacctag 80940
atctcatcaa ctccctggtt ggttttggcg gtcaaggctt tttatgccag agcaactgtg 81000
agccaggttt ctgaggttct tcctgaccca tgttggtagc ctcttaaaaa taactgtcat 81060
tccaagttca gctaaaatat ataactcaac aaataaatac atataaagca tatgaataga 81120
agcgggaaag tgaggattaa cagactggag agtaagagtc ttgccatgta aaatactata 81180
aaacactctt aggaagtctc ttgcttatgt tattacttgt acagtaaatg tggagacctg 81240
gatctcttcc tcatggtccc ttatttcttg ttttcctgct gggaggtttc aagtagctga 81300
tcccttgcac atgtacttta aaacttcaat tatatttgtc actggcttat catgggcaat 81360
gtatgtgaat gtgactaagg gtcctgataa attaaatgcc acttttacat gttcctttct 81420
ttttcttcta ttagtgttct ttaggacttt gaatgggaaa tcctcaaaca tgtaagtcta 81480
tgtggcttca gaaaacccca gagaggccag gcgcggtggc tcacacctgt aatcccagca 81540
ctttgggagg ccgaggcgga cagatcacct gaggtcagga gttcgagaca agcctggcca 81600
tcatggtgaa actgcatctt tactaaaaat acaaaaatta gctgggtgtg gtggtgcaca 81660
cctgtaatcc cagctacttg ggaggctgag gcacgagaat cacttgaacc tgggaggtgg 81720
aggttgcagt gagctgagat tgcatcactg cactccagcc tgggtgacag agtgagactc 81780
catctcaaaa aaaaaaagtt ctccccagtg gcctctactg aattatccaa gtgcttgggt 81840
agggggtgat gctgaggcct gggaatcttt aataagaaag aagaagggaa attccttatg 81900
ttggacccaa cattgagtgt gttcagatac agatgttggc aggtatgggg gcattcggaa 81960
ggagaacagc ggctaaccaa gctaactgag actgagttca agattcgctt ctggttcagg 82020
gggactttcg ttttcaggct ctaatacatt cagaagagca aatattggta ctttaatcat 82080
gcatcttttc cccctcaagt tctgtatctg ccacgtgtat attttatttg gcatttaaat 82140
gcacagttct tataattgct gataaatagt ctccattgca cattttgctg gcactgtggc 82200
ctcactgtaa atgctctctg tatgttcttg ggaagttgca taatggcagt tactctagtt 82260
tactgtgcaa tatgctcagt gactaatggc ctaatcatga cttgaaaaat atataaacag 82320
ttcaacagaa gcagttgatt cactgagctc tttcatccag acaagggtga gctaatggga 82380
ataaaaaaga cggaggtgtg cagcagcgtc tttgatgtat tgaagttaga gcattcccac 82440
aaatcccatg cattattgct cattgatggc ggatcctttt tcatatgcat gaggcaggag 82500
tgccaaatta tcgtcctaat tggctctgac ttggtattcc ttaatgttcg tgttacactt 82560
gttacaactt ttttcctttc ctctaaatac tactgacagt aacagctttg gagaggcagg 82620
ctgtcacgtg gccccatggc gtcaccctac actgcaggct taagtgtggc tctggtcctg 82680
tgctctggtt tcttgggata gaattacagc tgagactgtg cagtgcggac ctgcctggtt 82740
tacttcaggg gcattgttga ttgacacaga ttcttgttcc cttgtcctca gtggcacctt 82800
ttcttccaag aggaacagag atagagtctt acaacagcca ttaaatagaa gatcctgggg 82860
tctactggag cactgtccca ttggtgggga gaaataacaa tcatcatcat catgtctccc 82920
ttcctttgga attgattagg tagctcctat attccacatt cctctcacct gttgaccaca 82980
cacaattttt ggtcttgtag cttggccact cattttagct caatcactgg tttaattttt 83040
ttaatgaaat cactcaatcg atagaggcta acctctcgta gatgtaataa ttccaaccat 83100
tctcaaagaa ataatgaagg gtggaatatt atgctttcta aaataatgga atttattttt 83160
tctttatgcc cacagctgtt tagtcctaaa gagggggaag aaagaatctt tcgatctttt 83220
ggcatgttcc atgtcccgta ttgatggtca tacttcagct tttttctggt tgtttaagaa 83280
ttatgtggcc aataggctgc cttgtatata acagtgaaaa acacccatta cttgtatttg 83340
tttcatttta aggtttaggc agttggagca taggacagta actggtttcc cttgttttct 83400
ggaacctgcc ccttgctctc tcttgggtga tgcctcaccc ctgccccagt gtcagagctg 83460
ccctgggtcc ttcttccctt gaagggtctg atgaatgaac cacacagctt gttagtatct 83520
cagtttgtta atcctcccgg aggaatgtat gtttcaaaaa agaagctgaa aagtataatg 83580
gatgagaatt tgctttggaa ctcagcacac tgtagattag agaaggaaaa gaaagaaaag 83640
gaaggaacag aaggacatgt ttggggggta gggggccttt ctggggcttc tgaaagcaaa 83700
tgttgtgata attagttaca gtgtcccaaa gatgcctggg tctacccctg accctctaca 83760
caggccaatt ctgctcccac cagaaaaaaa caagagtaca gagcaaagag gcagggcagc 83820
agcctctgat acctatttga actttacaca ttctgataga atttattatc tgtattgaat 83880
atgggagact gtgggtaaaa gacttcaaga cagtgaaaaa ctaggaaaga aaaataaagg 83940
tgtattgggc cttggcaaat ttttgacact tacttgacta tgtgctttaa ctttttgaaa 84000
aggcagataa tatagcaatc acattaaata tttatcttta aaagaaatta ttttaaaaat 84060
tactcttaat attaccacat tatgaactca ataggagatc ctacagttcc tttaacttta 84120
acaacagtac atttgttaat attcattaaa gttaaagaag cttactatta caacagaatg 84180
aagtaatact tgctggaaaa caccaatatt ttacttatct ttatctaatc cccccgttta 84240
actgtagtga tacaatactt aattttaaaa gaggaatggt ttgaatgtac agacttttac 84300
atgtgttctt ccattgagtt ctttcttgta gtctaaccca atagttatca cacttcagtg 84360
tacatgaaaa gtgcagtaaa ggattgtgca gtatacataa aatcctgtgt ggagtgtctt 84420
gtgggaaagc caaaggattt tcaaagttaa ttttgactat atatgacttt tgcttaactt 84480
ttgaacttaa ccgcccacat aaaaactcac tccactatat ttcccttctc tttgcctccc 84540
tacttctgtc ccccctttct cccttttttc cttcctccct tgtattcttc catccatcca 84600
tccatccatc catccatcca tccatccacc cacccaccta tccatctatc tatcctccca 84660
tccacctatc cacccaccca tatatccatc catccatcca tccatccatc catccatcca 84720
tccacccact aactcatcca tccatccatc cacccaccca tccatccatc tattcatcct 84780
tccacccatc cgtccaccca cccacccatc cattcatcta tccttccatc catctattca 84840
tccatccacc catccattca tccatctatc tatttgtcca tccatccacc ctcccaccta 84900
tccatccatc tattcatcca tccatccatc ttttcttcca tcactccttt cttttttttt 84960
ttttgagatg gagtttcact cttgttgccc aggctggggt gcagtggcgt gatctcggct 85020
taccgcaacc tctgtctctc gagttcaagc gattctactg cctcagcctc ccaagtagct 85080
gggattatag gcatgctcca ccacagccag ctaattttgt atgtttttgt agagatgggg 85140
tttcaccatg ttggtcaggc tggtctcgaa ctcctgacct caggtgatcc acccgcctcg 85200
gcctcccaaa gtgctgggat tacaggcgtg agccaccgca cccagcccct tcactccttt 85260
ctttttctct ttccctgcct tccttttgat aaattaactt aaacattttt tttggtgaaa 85320
ttaatatggt gatgtctact tatatttaaa tcagaaaatt attagtatgc tgaatattcc 85380
aatctcttag gaatgataaa aatattctat aaaggtcaat cttaattcca catcctatgt 85440
tcctactcag ctttctgtct ctgatttctc atttttagct gggaacatcc cagccaaaag 85500
acagccaggt tctctgtgag catagcatat caaactaact gtaagaaaat aacattttgg 85560
cttaaaagcc atcttctaat ataagataga ataaaaatga taatgattgg tatactatgt 85620
ggcattgtta gtaagaattt gaagtaagat ttacctaaat cgctgaaaat attgaatagt 85680
tggctgagac tttagaattg gtacaaacat gtacattttc tcaaaatcaa aagaattaaa 85740
atagatatcc aagaagtcag attatgaaaa aataagatag tcaacggaaa tcctaaaagt 85800
aacttaaaca ttggcattgg acatatttca tttgtatttc tgccatagaa gagttaagtt 85860
aatgtgcatt tttgccatgc aatggcaaaa tgaagagact tttttttccc ttctttttgc 85920
tcttggtaaa attaagtggc aaagaaaaga tagctctgag gttattgcta gaattttgtg 85980
ctaaaaacat tttggctaga gcagcaagtt tttaggcaaa cagcccctga taaaagttgc 86040
aagaaaaaaa tctcattcga gtgcaccaaa cacttttcag atgaccattt aattttttta 86100
agttgcataa acaatttcaa gtgcactgta aatatagaaa atagggtatg atagttgaca 86160
gaaacagaat gaattaagag cagtaataga aaattgtaaa caattatatc tgaatttcat 86220
cagttgtctt gcttacattc acaattagtc atcccgtgaa agacataggt gaacatttag 86280
ctgcttaaaa aggaattagc tgcttgaaag gacaaatgtt catgttaaat ttcatgaaga 86340
ctaaccttca gcagacaacg gcacaaatgt gtcagctttt tctggtgtga atgaagcaag 86400
atacaggcaa aacagatgag ataaatagga cttggaaaaa aaattctact atacaagttt 86460
tgtatcccca tctttttgct ctttgtggag cacctactgg aaaccactcc tgacctaatg 86520
atgaggacac agagagaaaa ttcaataagc aatggcctga aaaataattt ttatctaagt 86580
attagataaa cgcagtagca tatttgactt gtaaaaataa catggctagg ctttgtatgc 86640
ctccctgtcc tcttacctac gtgggatttt caaatagcac tgattctggg gaggggaatc 86700
aaaaaataga agactcccct ctcccagagc acacgtaatt aatgcctgtg ttgcagctgg 86760
gagctctctg ccagcagagt tctttgctcg tcatctctca gcgctcaccc acattcccct 86820
tgattcacac cgtattgttt gtttacatgt ttgtctccct gactcaggtt ggaaatcttt 86880
aaggacaagg acaacctctt gttccttttt acatttccca tggtgctttg ctcgcagtgg 86940
ccactacaga catgattcat tcattgtttt aaaaaaagtg ttaactagtt aagtgaaaat 87000
aaaatgaaac agcaaaatga gacaaacgcc tagatctgaa aggctacaaa atacagcaga 87060
gggttcagtg gacataagag gaaaggaaca caatgatatc cccaatcttg tgatggaata 87120
gaaaaaaaaa aagtgattgg tgttgatgta acacttttct tggccagttg aacattccag 87180
agtagaggtc agttttgtag ttaaatctgg taggaagatg tttccaacca gaaggaatca 87240
tactaaaatt attttatcac aacaagcagt ccataaccga aactttaatt tgtgagttgg 87300
gaatcaggat aggaaaccca attttatatt ctttttatag gaagaagaat ccattccacc 87360
actcagactg ctttcctctt tcataatcgt ggcatactct gccattgttt gtttattttc 87420
cccacaacta gatggagagt gcaaggacca tattttactc atgtgtatcc tcagggccta 87480
gcacaaagta ggcactcagt aatgaagaag taagatgttt caatgtccct aacatttaaa 87540
aggatgtatg aaactagtgc taataccaga aagagttggt tttcataggc tgttaattgt 87600
gggttttgaa ataatgtact actttgtaca ttgattttat acaactgtgt tatatacttc 87660
agtaactttc aaggtaaaaa gttagaggtt attaaatctg gcagggtctt aaaacctgag 87720
tctcagtcca tgtaagagca ttcttttgct cttcttgact agccatgtaa aagggtgaat 87780
gtaagttagt gaattatctt ttagaaatct tcagttgtat atatattttt ttcatcgaat 87840
tgcaaactca ctcacactta ccaatgtaat actaccctgt tgatgagcat tagtagcctt 87900
atttgggtag ccagattaga gacacaggct tcatggtgtt acctgccttg atgttttcat 87960
tcataatgca gcatttggga atgcagcatt tttctatatt ggagacatgt atgatgatgt 88020
gtatgttcct tccccataac cctgtccgct tctcctttgg cagtgtcttg catcacaatt 88080
ttattttatt tttatttatt tatttatttt ttgagaaaga gtctcactcc gtcacccagg 88140
ctggagtgca gtggtgcaat cttggctcac tgcagcctcc acctcccagg ttcaagtgat 88200
tctcctgcct cagcctcccg agtcgctggg actacaggta tgcaccacaa tgcctggcta 88260
atttttttta tatatttttt ttagtagaga tggggcttca ccatgtcagt cagactggtc 88320
ttgaactcct gacctcaaat gatccgccag cctcagcctc ccaaagtgct gggattacag 88380
gcgtgagcca ccgcacctgg cctccaattt taaatatatg taggctccat ctccacctct 88440
ccctgaaaaa actttccctg ctcctttcgc cttcatgtgt gccataagtt gactgccatc 88500
aggccaatat cattacatat aaattccctc cacccttcgt tttaatttta aaatatctga 88560
aagggggaaa gggagaagat tccctaatga gtatgttgtg tgattcagga ccttggctct 88620
tagatcctca gtcatgtgat attttcagat tttatgggac tatggtgcaa ttgaagaaag 88680
gcttttgaca gaaaatgtga aatgatgaag tcttagcacg gactcatacg gcagtatttg 88740
attgcgggtt aatctccaaa cgttgaaata aagtggatct gttaaaaagc cattggttac 88800
tttcagttgc caggggtgtg tatgctcaca ttcctggaag cacattctat aaagtcacca 88860
atctacaaca cagacaccca cctcccccta gacttcagag agctctgctg ggctgcagct 88920
ttctaccaaa agagttgtgt gcctctgaat ttcacatcca accttggaag ctgcagtctg 88980
tttaagattt cagaaagaat gggggctatg tttccagttt actgctttgt tattttgaaa 89040
ttgaaagtct gagcagaatt cagaactaca caaaacagga tcttttcaca tgtttgttta 89100
agtcatgttc ttggcaaaaa cttgctgagg aaatgatctg tttctctagg agcattgatt 89160
tcttactcca gtacagtggc catttcccag gatctcattc caaaccatct gttttgccat 89220
cagagccagc ctttcagtga atgatctctt tggtctacac tgtgctaaac cttctgattg 89280
aaaggatttt tattaatgaa atctaggtaa taaagttgca gtgaacttta ggaagttctc 89340
tgtaggcagg gcgtggtggc tcaagcctat aatcccagca ttttcggagg ccaaggtggg 89400
cagatcatga ggtgaggagt ttgagaccag cctagctaat acagtgaaac cccgtctcta 89460
ctaaaaatac aaaaaaaaaa aaaattagct gggcgtggtg gtgggcgcct gtaatcccag 89520
ctacttggga ggctgaggca ggagaatcgc ttgaacccat gaggcggagc ttgcagtgtt 89580
gcagtgagcc gagatcacac cactgcactc cagcctggca acagagcgag actccgtctc 89640
aaaaaaaaaa aaaaaaaaaa aaaagaaagt tctctgtaac agtcaaatag caagtgctga 89700
cctctgtcgc ctctgtagca gcagtatgga tgaattgtga gcttgttggc taggttgggc 89760
tgcgggtcat tgtggaaaag ccatgtttcc cttgcctgtg gctgggaata agtatagtgg 89820
ggccatttta aaaaaaagtc ctgtggttga attctgagtt tgagctgttt taaaatgtca 89880
aacagactga atccttggga gactcatttg aatgagacca gcagcaatgt aagaatatat 89940
atatatataa aacacgttag agcatttcca tgtatgggag ggaactgatg gagagaacac 90000
agaccaccac attaactgcc acatgctgtc aaccagtgga tctcaactgg ggaccatttt 90060
gccctctcag gacatttggc aatgtttgga gacacttttt gatcgtccca aatgggaaaa 90120
caaggtagca atactggcat ctagtgagta gaggccagaa atgctgctga acatcctgca 90180
atggggctgg gggcattggc tcacacctgt aatcccagca ctttaggagg tcgaggcagg 90240
aggatcgcct gagctcagga gtttgaggct gcagtgagct gtgatggcgt cactacactc 90300
cagcctgggc agcagagtca ggggtctctt gaatgaatga atgaatgaat gatttttaaa 90360
aatcaatcaa tcaatcaata tcatatccta caatgcacca aacagtcctc tgcctcaacc 90420
aaggatcatc tggcccaaaa tgttaatagt gctggagttg agaaaccctg ccttagaccc 90480
tttccttctc atagtttcca agctgataaa tcagcctgcc ttgacaaagg tgaggaggta 90540
agctgcaggc gtgagtggga agagcaggat aaggaaggaa acggagaaaa gaggtagcag 90600
cattgcatga aaataaacta cccgggccat atcccatttg tgccaaatta atatttggga 90660
ttctgtcttt atgtgtttgg taaagccgga aagtatgtgg gtggctggct gggccatggc 90720
ctttgtgtta gaggtgacct gagtttcttc aaagcacctg tgttagtttt tcattgctgc 90780
tgtaacaact tatcaggaac tttgtggctt aaagcaactg tttttatctg acagttctgc 90840
aggtcagaaa tccaatacag gtctcaccag gctgaaatca aagtgtcagc caggctcatt 90900
ctctgtaggg actctagaga ataattcata tccttgcctt ttccgttttc tttcttttct 90960
tttctttttt tttttttttt ggcggggggg aacggagtct cattctgtcg cccaggctgg 91020
agtgcagtgg cacatattgg ctcagtgcca cctccgtctc caaggttcaa gcaattctcc 91080
tgcctcagcc tcccaagtag ctgggagtag cccagcacca tacccaacta aattttatat 91140
ttttactaga gtggggtttc tccatgttgg ccaggctggt ctcgaactct cgacctcagg 91200
cgatccaccc gcctcggcct cccagagtgc tgggatcaca ggcatgaacc atcgtgcctg 91260
gcccaccttt ttccattgtc tagatgccat tgtatttctt ggctcctggc cccttcccct 91320
atcttcaaag ccatcaatgt tgcatctctc tgtgctgtgt ttccatagtt gaatcttcct 91380
ctgacacttc ttcctccttc tcagactttt aaacttcctt gcgattacat tggacccacc 91440
tgtatcatct ccccatctcc agatccttaa tgtcatcaca tctgtgaaat cgcttttacc 91500
acgaattcac agactgattc tggggattag gacgtgggta tgtttgaagg tcccttgttg 91560
tgcctaccac agactccaag gcatttacta gagccacatt ttgctgactt gagctagatg 91620
tagcaaaaga agtgttataa aaatgggttt ttaaaaaagc cttttttttt cctgtggtat 91680
aattttagtg tttagaagta atttttcttt taatgcagta tgacacagaa aacatttgga 91740
ggatgttgaa aagtaattgt ttaaattggc aaagacacat ttcagtaagg gagtaaacaa 91800
gagggaaacg tgttgggggg aaaggtgtgg ggaggaaact ctagaccaga ggccctagga 91860
cttgaatata caacttagtc ctgttgaaaa ttcagattcc tgggccttaa agtatgttaa 91920
ataggtcagg ggtggggccc aggagttgta cttttaacga gcaccctcct gtgattcatt 91980
taacataaaa ggtccttggc tcacacttgg agaaacactg ctgtagaaac tcaaatacct 92040
attttaaaac aaaggtacat tttaatcatt tagtttaaaa tgaaatcatt gcataatact 92100
gatgttagag gttagaataa acatgtactt aagttcttga tattcttgtc atttcagtta 92160
catgtcaggg aatgtgattt gtgttttgac gtattcaaat ccttgtcata ttcaaccata 92220
ttcgtattca aaatatataa tgattttgac ccttgattgt tcgaattaag actgtcatct 92280
tttctgtgtg attaactctt gtgttgatat aaatatgcct ttggcttact aatgttcagt 92340
aagaactaat gactcttggg aatgttaata gactctgtga gtcccttttt aatcatttgt 92400
aaccaggctg tcattccatg tttgtttgga agcttagaga taacatttat gaactttgtg 92460
acacatagta gttgctcaat aaatgttaac tgtagaaaca cattgattag tttcacttca 92520
gaaatagaca cttagagttc aaaattccca tctgcctagc tcctgaggcc cactttctta 92580
ccagaatctt tcctgatacc ctctcctgca taaaatggtt cctcttttga gactttgtag 92640
ctcttttgta cttctcttat tctgttacgt tactgcaaaa aaaaaaaaaa agaaagaaaa 92700
gaaaagtgcc aattgtgtac atgctttcct ccctgctgga atgtaaactt tgtaaaggca 92760
tgatccatag cagatacttc ttattacaaa ctacctggca gaatttcttt ctaaagaacc 92820
tactcagtaa gcctgttggt gaactgagca acatttggac aattatggca tcatcttaca 92880
atttttcagc tattggtttt cacttgttta gaaatgtaaa actttgcaag gacttttata 92940
aaagcaaatt tcagaatagt tattcactaa gcttttttat gctaatgatg tcatgctatc 93000
aaaaattagc tagagtaaat ggactgtaat gaggatggtt tgtaatctag attatatgtt 93060
ccacatgtaa catcgaaatg aaatataaaa ttgagttgtt ggcatgtggt tgtggtgagc 93120
agaagcagtt attatacatt acttggtaaa attcatattc atatcttgtc agtttacagt 93180
gagccagaga ttaaaaataa catttgtttc tgttttagta actgcttaaa aatatccaaa 93240
atcattttat tttctttagc ctgacttcta gtagtgtttt gaatatgtgg cctttcaagc 93300
agtaatgaaa tgcatcaatg cgacttggca gtgcctcaca ggacatgctt ctaggatcat 93360
ttttaatgat taaaagtcaa attgagttct aaaaaactga cccaaaatat agatgagcca 93420
agtaaaaacg gaaggaaatc tgaataaaat cttggttctt ggtcctctgc atgtatcctc 93480
cacatctgtt ttctccagat ctcttttttc ttgcttgttg atagcacaga ggaagatcgc 93540
agagagtaat gtactgtata tgtttcacat cccccttcct ctttagtgat agtttggaga 93600
gtatactgca gtcaccatgg ttttcagttt ggagagtaca aggatcagat ctgtattttc 93660
tagagccagc ttttgtggca ttctggagag gtgattggag aaccatgaga gcaggcagac 93720
atctgggtga gagggcacga ggggtgagtg acggcagagc cagacttgct ggagaggcag 93780
aaagggaagg attcaagtag cataaccagg aaatagaatt gataggattt ggtccctgct 93840
gacctgtgga ataaggggga aggcagagga gttgattcta gtatttctaa gttgggccac 93900
ttagtgatat tggggtacca ggaacaggct tagtggaccc acagaagtga ccagacccag 93960
gagtctctct gagcgcccac cctggcttct ctgtgttggc ttaccctttc ttggttgggg 94020
gtcatggggt ggtcagcttc agtggtgtgg tctgaggtga caggtgctca ggagtgagga 94080
cagggagtag acatcaccaa tgtgaatgtg gaggtaggca acaagagtta ttctagaact 94140
gacaaattta atatattttg ctgactgctg agttccattt ggacaaatac ctaatgcatt 94200
tggggcttaa aacctagatg acgggttgaa gggtacaaca aaccaccgtg atacatgtat 94260
acttatgtaa caaacctgca cgttctgcac atttgtccca gaacttaaag taaaaaaaaa 94320
aaaaaaaaaa aaagattgtt cagttcagtt cagagagcaa taggagcagt ttgctattca 94380
ccaaataggg acatcaattc tttactgatt aatagcagtg attcagaaaa ctgccttttg 94440
tagtagagca caccaagggg gtctgccgga tggaaaaaga gaacagtgct ttgtgaacta 94500
taattgttgc cataagtaaa tacttaaaat acactaaaat ggcaacatca ggaaacatga 94560
ctaaggagtc agtgtacgcc acgccctttc ccccaccttt gtggttgttg aaaatttcca 94620
ccaagagtga tgtatacaaa aaagggtaag atcagggtgt taggtttcag aggaaggcaa 94680
aaacttgtgt gattctataa atggagctta caaatggaaa tgcaccattc aaggcagaaa 94740
gtctatcaca gtcattagga ataagcatta gagtgattct cctttcttaa cttctgcaca 94800
gaagtttgat gtggtaaaga aacagtctgc tcttagccat gttccttgaa aatacatgtc 94860
ttcaattact tggtttgtct gagagaaagg agggtttgga ggagaaggaa atgcctcgtg 94920
agtttgacat actatgggag gattgttgtt attattgctt gatttacatg ctctcatttt 94980
atacaaagtg tacagcacaa tttctcaaag agtaattatg atgccaagaa aatggggtgg 95040
attctgggct tcctgcagtc tgtcatccaa ataataatat tcattacaaa gatccttacc 95100
caggaggcca aggtgggagg attgcttgag gccaggagtt caagaccaga ctgggcaaca 95160
tagaccccta tctcaaaata aaataaagta aataaaataa aataaaataa aaaataaaat 95220
aaaataataa aagctccata ccagtttgtg gcattcctac tgaaaacaga ggtatacgaa 95280
atgcttgaac agggcatgga actggaggta tggatgtcat taagaatggc tgagaatttt 95340
ttgccaagag ttagtatact atcctacttt attctatttc agtttgcagt aggacagacc 95400
taattctctt ccctgagaaa gtcacaaata aactagcatg gagcttctca gtgggcaccc 95460
ttggctgaac tctatagact cctgttctct ttaataatat ctaaagcttc tggttcaatt 95520
acatggctaa tatcttgact ctcaagacca aaaggcaaga tgtttaaaaa taaaatcaac 95580
gttaaaaaca tgcctgtgtt ccatggacac aggaagggga acatcacaca ctggggcctg 95640
ttgtggggtt gggggagggg ggagggatag cattaggaga tatacctaat gctaaatgac 95700
gagttaatgg ttgcagcaca ccaacatggc acatgtgtac atatgtaaca aacctgcaca 95760
ttgtgcacat gtaccctaaa actttagtaa taaaaacaaa aaaataagaa aacaaaaaca 95820
aaaaaaacat gccagtgttc tttagtcctc actcaattag agaaaaatga gagcaagcat 95880
gatattttgt atctggcact atgtgcactg ccttgagaga tttctctaga aggttttaag 95940
aacatctgtc atctattaat agttacgaaa gccgagactc acacaaatga ggcaacatta 96000
cagggggtca gagagcacat aggtaagccc accttgatgg gagtcctggc ccgaggcact 96060
ttggggaaag agtgagctgc agtggttata gaaagacaaa tgtcttgagc cgggcattga 96120
aaaatgacta agaataatct agaaagtgtt cagtatgttt ttaacgattg tgggttagca 96180
gaaggaaagc catctgaggt gagagaaata ataagcaaag gggacagagg tggatggtga 96240
atcaactgac ccaagggagt taagcgttta gaaagcactt caaaaggata acactacata 96300
gctccttgcc ttactgtggt gccttagaga tgactggcat ttttgcagag cttgtttcat 96360
aaatgtgctt tcagaggaat aaacagggga ttcgggctgg gctgaggata ccttgaattt 96420
tgtttacaga ccatcatttt gtttacagaa catcagtgct ctatcctcat gtccttctaa 96480
gaatcaaaag ttttaacctc acagaatcca gcgtgtggct tgtgagtgag actccttttt 96540
ccatgtgata accggtctgc tttggggagg caaaagaatc ttaccgacac gtacatattt 96600
taggatgggc tctgagccaa ttcatcaagc caactcctca ctttgaaaca agaaagtgaa 96660
gaggatgttt catgattgtg gaatacctgc cagaggaaga atctaccgaa gttcagtcaa 96720
ctattaattg gaaaggaggc agcagactga ggagatagag aatctttgct ctcaggtgga 96780
tggaggttgg agtcctcaat ctgtcacttg tgggtacatt atgtagctcc ttcacctcca 96840
tttctttatt tattagaagg cgggtaataa aagtgtccac tgcctaggat ggttctaggg 96900
cttagaggag ataatgaaac tcaagggctt aacatgtgaa tgttagctat tatcattgca 96960
tgtgtccatt aacacccaaa gataaccagt gttgtttagt agttctttgc gtattttctt 97020
tctaaataga taatgattta taatttacct agttacttca tgaattgatt tcatgaaaaa 97080
ggtctttctg aatctctttc catgtacttt aaaagtttat tcctttagtt aaaagaaatt 97140
ttaactagat tcttaaagcc tagattggaa gaaagtgttt gctaaaaaaa aagtcatggc 97200
tgggtgcagt ggctcacacc tgtaatgcca gcactttggg agaccgaggc gaacggatca 97260
caaagtcagg agagcaagac catcctggcc aacatggtga aactccgtct ctactataaa 97320
tgcaaaaagt aactgagtgt ggtggcatgt gccagtaatc ccagctactc gggaggctga 97380
ggcaggagaa tcactggaac cagggagtca gaggttgcag tgagctgaga tcacagtact 97440
acactccagc ctggtgacac agctagactc caaaaaaaaa gaaagaaaga aaagaaaagt 97500
catgtatata tccagaagaa aggaaatcag tatattgaag agatacctgc actcccatgt 97560
ttgttgcagc tattcattat agccaagata tggaatcaat ctaagtctcc atcaatgaag 97620
gaatggataa agaaaataag gtacatatac acagtggaat attattcagc catacaaaag 97680
aatgaaattc tgtcatttgt aacaacatgg ctggaactgg aagacgttat gttaagtaaa 97740
ataagccagg cacagaaaga caaatatcac atattctcac tcatatgagg gagctaagaa 97800
acatgacgtc atggagacag agagtagaat gatggttagc agaggatgga aagggtagtg 97860
aggagggagg aataaagaga ggttggttag tggctataaa aatatagtta gatagtagga 97920
ataagagcta gtgttcagta gcacaatagg gcaacaatag ttaacaataa cttattgtat 97980
atttcaaaat aactagagga atgaatttgg aatgtcccta acaaaaagaa atgaagtgat 98040
gggtatccca aataccttga tttgaccatt acacattgtg tgcttgtatc aaaaaatcac 98100
atgtacccaa taaatatgca caacgatcat gtacccataa aaataaaaca aaattaaaaa 98160
tgcacacttc tcacagtttc ttgcctagta gaatccaagt aaatacagtt ttccgcccac 98220
agataactct tccctctggt gccctcatgg tttatctcat gttcttgacc acatgggtta 98280
atggtctttg ttaggttgta ctcagtgatc cccaagagga caaatggtgg gaattatgga 98340
aattgaggcc agaaggaaac ctagagttct gtgcttttac ttccagtagg gatctgtggg 98400
gtttagaatg tctgcctggt cagcagttct cactttggga acccccccac ccccacccaa 98460
gaccttttct ggagggacat ctgtaagatc aagattattt ttatggtaat actaagacat 98520
tatttaccta ttccattccc attctcttcc atgtgtacag cggagttttt cagaggctat 98580
atgatgtgtg atgatattgt gtaatgaaat gtgtcaactt ttggaagatt tgcataattc 98640
actgaactaa tataattttc caaatgacca gggtatgatg ttacaaaatc atgcatagct 98700
aaagatccat ccaaagttca agatagacta atgaatttta atataaaaga atacttagag 98760
tttatttcta tgcttcagat tccatggtgc tgctcccctt taagaaacta ccacttattg 98820
agttttggta tgatataaaa aaagaatatc cacaattgct gaaactattg gccacatctt 98880
ctccacatac ttcaaccaaa caacatatca cagaaaactg aattcagagg cacagaagag 98940
aatttaacca ttttccatta agccaggcat taaagagagc tgcaaaaatc taaatggatc 99000
tcactcttgt cactaacttt tttgttctga aaaatataat tattttttca taaagatgtt 99060
atttcatgta gtatgcaatg ggtatattag tatttctatt aaatgaacta atgaatattt 99120
tacatttttc tcaattttgc ttctaatatg gtataatagt tgttaaatat gatctaccta 99180
atgaaaagtt ccttggggtc ctcaataaat tttaggagta tagaggaaac tttatactct 99240
taaaatttat tgaggaccca aggagctttt aagtgtgagg accaaaagtg tgaggaccac 99300
tggcctagtc tggtcagtgt ctacaccctg tgtccactgg tttcaccttt cttctggaaa 99360
aagtgttctg tggtaaaata tattttgggc ctagatgagt gctttctccc ctcatagatt 99420
tacaatacac atgaacatat gagaccctcc aaagtctttc ccaaatttat cccaaccttt 99480
aaaaacaaat tatcccaacc tttttttatc ctccttttaa ttttggcaca acataatgtt 99540
ccacaatgga atataacatc ctatggaacg taccggctgg tatatgatat gggctgccct 99600
ctttccgtta acaaaaaaat taaaagcaag acattttcct tcaaatccat actttattta 99660
gagagaggcc tataaaattc acttgcgaat ctgattgact ttcttaaaaa aacatactct 99720
tcattcattg tattatgcca ttttgcttat actctttgaa gctgtttcta cttctgtttc 99780
caaatgcata tgttttttta aagctctgtt ttagacattt ttgtgtgtta attagtagca 99840
tctgctccat gtgtcataag acaaagtaat ttcatcccca caaaattgtc caaattgcag 99900
gttaagtggt agcagcctag ctgttgagct gttactactg tttggtattt ttaaatggca 99960
aaaaatacct tcggtgatgc atcacatgcc tttaataaaa cacagtcact ttgggtaaca 100020
gaaagattta gaaatggcag tgggttttgt tgtatttctt tttatgattc tttctttcca 100080
gtgctttagt ttccattggt tgtgggtaca atcctaagag tcagaccaaa ataaagaata 100140
ttccatcagt atggatcaaa aacatgttcc tggccggaca tgatgggtca cacctgtaat 100200
cccagctact tgggaggctg agctgggagg actgcttgag ttgaggagtt cgaggttgcc 100260
gtgagctatg atcacaccac tacactccag cctaagtgac agagcaagac cctgtctcta 100320
aataaataaa taaataaata aataaataaa taaaaaatta aaaaacatgc tcctggctgc 100380
tgcgtgatga gcatcatctt cctaagacat gagactgata cttgcaccac ccagcaccag 100440
tttcttcccg gcacagtgcc attctaaatt tgtattgagg caggagtgca gcgagaattt 100500
ctttctcctt ctgtatttca catgtctatg ccacagaaag aatagaaaca tcttaatttg 100560
ttataataat tatagggaca atagtcactg tattttatat aattcaaaag ttctttttaa 100620
aaaatttttt ggtcttgccg gttcctactg aaacacttcg tacagtttga atccttagtg 100680
actttctatt gccaactgaa aattgatttt ttcctatatt aaaaaaaaat ccagccgggc 100740
acggtggctc ctgcctgtaa tcctagcact tcgggaggcc gaggtgggtg gatcacctga 100800
ggtcaggagt tagagaccag cctgaccaac atggtgaaac cccgtctcta ctaaagatta 100860
attagccagg catggtggtg gacgcctgta atcccagctg cttgggaggc tgaggcagga 100920
gaatcgcttg aacccgggag gcagaggttg cagcgagccg acattgcacc attgcactac 100980
agcctgggca acaagagcaa aactccattt caaaaaaaaa aaaaaaaaaa atccaaacag 101040
aaaatactgt ggctatctta ttcagtatct tgttcttttc cttaccactg agtagtttca 101100
gggaaaaccc tttacaattg caaaaagaca ttcagtttat aggactattt attacagcgt 101160
tggcaaatgg tgctggaaat tctctaatag ttaaatgacg caaattaacc agactgaaat 101220
ggaagaacca tactgaggtt gctcttcaaa cagcaagagg ctacctttct gttttctttg 101280
acaactgaat atagcttatg atatagttaa ggtatcaaag atgcaagaat tgtagagcta 101340
tgtggcaggt taagaagcct gatgaatggc cgggtgcagt ggcccacgcc tgtaatccca 101400
gcactttggg aggccgagac cagcagatca cctgaggtca agagttcaag accagcctgg 101460
ccaacatggt gaaatcctgt ctctactaaa aatacaaaaa attagctggg cgtggtggcg 101520
tgtgcctgta atcccagcta cttgggaggc tgaggcagga gaattgcttg aacctgagag 101580
gcagaggttg cagtgagctg agaccacacc attgtactcc agcctgggca acaagagcaa 101640
aactctattt caaaaaaaaa aaaaagaagt ttgatgaaga tgcagatgct tcattgcttg 101700
tgcaaattgt gtgattttag catattctac agtggaaagt caaatttcag gcatgcacac 101760
ctaaagtagg aaaaatggtt cttaaagggg tagtgtgatg cagggattaa gaacctggtt 101820
tctggagtca gatggcctga gtttgagtcc cacctctacc atgtatgtgt gctgttgaac 101880
aggtgattta acttctttgg ggctcagttt ctcccactgt aaaaagtcat gtaaagttcc 101940
cagaagagtg tttcatacat tgtaactgta gtagttatct actgctgtgt aagtaattac 102000
tccaaatctt agtggcttaa aacaacaagt gtttattatc tctcagtttt tctaagtgtg 102060
aatcactgca tatcatagct gggtgtctct agctccaagt ctttcatgag gttgtagtca 102120
agttgttaac ctgggctgac gtttcatctg aaggataggg tgggggcggt agggatctgc 102180
ttccaaatcc actcacatag atgctagcag gcctcagtga tatgccatgt gggcccttcc 102240
acaggactgc atcacagcct ggcagtcagc ctcccccagg tgagtaaccc agaagaggat 102300
gcaagatccc aagatggaag ccaccatctt catgtaaccc agtcttggaa atgatctccc 102360
attacctttg ccacagtctg tttgctagaa ttgagtcact aaatccagtc cacactcaag 102420
aaggctttac aagggcatga attccaagag gtgggatcac tggaagccat cctgcaggct 102480
gcttataaca gtaacttgtg ctttaattta tatcccctta tggtctattc ctgacaatca 102540
gaccaaatga gcccttaaaa tgtaaggcag atcatgatac tactgcatta aaaattatct 102600
ctggtcttcc cattttactt aaaagtcggt atctttacaa tggcctacaa ggcctttcat 102660
gcttataaaa ttatttttct atattttgta aaataatata tatgtataat aaatgctata 102720
tatgtatatt tgtataaaca catgtttata tgtttagtta tatatctaga atttattttc 102780
catatggtgt aagatagcaa tctctttcga aacgaagagc caggtttccc agcactattt 102840
attgattaca ataccctttt cctgggccag gtgcggtggc tcacatctgt aatcccagca 102900
ctttgggagg tcaaagcggg tgaatcacga ggtcaggagt tcaagaccag cctggccaac 102960
atggtgaaat cccgtctcca ctaaaaatac aaaaattagc tgggtgtggt ggtgggcacc 103020
tatgatccta gctacttggg agcctgaggc aggagaattg cttgaaacca gaaggcagag 103080
gttgcagtga gctgagatca ctccactgca ctccagcctg ggtgaaagag caaaactctg 103140
tctcaaaaaa aaaaaaaaaa aaaaaaaacc aaaacaaaat aaacctcttt tttccctgag 103200
ttgatattct actgagaacc tgtttgtctc ttattatgca atctgtgtct aattgttgca 103260
tttttgaata aagatatact tagtgggtct agtaaatcat ataagatagt tgtgtttgtt 103320
atgattttat ttgatttgaa acattcaaat acatgtaaaa acaaattata attgagaatt 103380
aattatggca aacatttaat aagttccttt atttgataga ttaggaacta attttattta 103440
aaaggccgtg acttacattt aaaagtccaa ttagctacaa cattaagact aaaaagtata 103500
tttcatgact cccaggtcac tgtttatagg ttgttgatat cccatacttt gctgctgctg 103560
ctgttgctta taactgttca gaaaattttc accaaaatgt ctatcaaatt ggaaaaccct 103620
ctggagtgag atccttttta aaatatagcc aactttcaca tatgcaggca tatctgtgaa 103680
tgccctaggc ccctgtgctt tctcttctgc tttttgggct tttggcctta tctttgctta 103740
tgataacttc aaatggtaaa caagaaggga taggtgacag agattaaacc caagccagtt 103800
tgttttgttg attattatta acggtattga taaagagttt gctgaaagag ggaagcatat 103860
tgaaattatt gcttaaaaag aagtgtgtag aattttcagt tgttttcttt tgataagagt 103920
tgcctcatag ctgttgtagt atgtgcaaat gaaggtcagc gataaatcac agaatgaatc 103980
acttccaact ccttcacatc tacagatata agtaagaatg gaaaatattg tcacttagat 104040
gagtccttat tttttttttc tgtatgaata gtataaacct tacttttctg gacacctagc 104100
tttggcagct ggtgaaggtt gttaaagtaa caaatgggac cattctgcct ctcccagatc 104160
gattttgctg caagatagtt gaaaataata taatccagaa atgaatttat tttcttatgg 104220
caaaaacaaa acagaaagag agtactatga ggaagtatca tgctactggt aaatttttca 104280
aactaaaacc gcattacatt tcattaaatg agtttatgtc cattaagcgt caatgagcat 104340
gagtggttga acccagaatc cagtcaaagt acatattaac tttctgtatg actttaaaaa 104400
gaggtatgtc aacctccctg ggtcagcagg ttcctttgca gaagacattg gaatgaaacg 104460
tcaaggacct cttccaatta tagaatacct cgagatatga agttggtaac aaataagaga 104520
aatgcagcaa gatattttta gttaaaaaag aaaagattga tacaagccag taacttgcag 104580
tgaacttgtt taaatcctcc tcctctctcc aaattctgtt tttaccaagc cggtaaagta 104640
aagacagttt gtcatgcttt gaacttcctg gcttatgttg atttctatca gtatgttgcc 104700
ttacacattt gagtgggagc tgagttacat aaaactaata aaatccttac aaccccattt 104760
tctgtgggta ctgatagcat ccaaaaaata aaaaaggctt ttgccatttt caggcagttg 104820
ttcctccggc tagatggaaa attgaatggc attatctcaa ctcacatgtt taaacattaa 104880
cggagagaca ctttctcctc ctcaaaagtt tttagtgttc ccaggaattt aaccacagat 104940
agacacaact cctcaaacgt cccgaaaaaa aggttgacta ttccataaag taatagttac 105000
agaaggcttt caaggaatta gttattcaca cagtaagctt ctgaggcata cgagcatatc 105060
ctctttctta caacttggtc acttgatcca atctttgatg atcaccgtgg gacctttgga 105120
gatttatgga gtttagggtt acaagtatga tgtggccacc atactcaggg aactggatga 105180
cagtcagccg atgggttttc aacatagatg aggatgagct cataaaaggc taaaaaagga 105240
ggcagacacc tttggaagac tgtttctagg ctctcaaatg gccattgtca aaaaacaaac 105300
agtggggtgg atttgactaa gcatcagaag atgctttaac aacagcctgt gacaagtgag 105360
cgttaaaagc tcacaaggca gaaaggaact tttcagagtg accttgtcag acgaggttct 105420
aatgtgtagg ctttatcagc tgctctgagt gggggtaaag aggcatgcat attttaaaca 105480
ttcatttcat attcagtgtg taaagtaact actgcttttc agcttgggtg gagaaagtat 105540
ttatcaagaa tcacacaagg gaaacccatg cattacctac ttatagggca aaatggaaaa 105600
tgttctctct cttatgcttt atcttttttg ttccatctta atagctcttt atttaaaaag 105660
tattcacatc agttgattag tctgagtctt tcatttgaag caaactttct tcactttctg 105720
cccttgatac tgcacatcag tctttaatca cttagacgta ctgaattttt ctttattcac 105780
atctttcaat cggtaaactt gaaattttgc aagtgcattc ccactggtgt acattctgat 105840
tttcaagacc tgctacctcc cccagtgtca tgcttgtttt ttttttcttt ctttcttcct 105900
tcccacaccc cacctccagt attttagggc accttatgta gataagcagt gagatggctt 105960
catcctgata attaacatgc ttgtttgagg ttatgaaata tacatttgag aaaggccagg 106020
gatttccccc tgaatatcca ctaactgctt gaagtggcat tttcattctg acttggtatt 106080
ttgttttgtt tgactgcagc atactggagc atagtgaaag agtctatttt gaagcttcaa 106140
acttagtgct gctgcagacc aggaacaaga gagaaagagt ggatttcagc ctgcacggat 106200
ggtcttgaaa cacaaatggt ttttggtaag tcatccaaaa gacttgacat cttttagctt 106260
taaatgtcat cgggcatcac ttcactggtg taccagaact tcttcttcaa gcgtattgct 106320
atttctctac atcctaaata acaggacatt tgaaaaaatg ttgtcctagt gacagagcac 106380
tgagagagca accgcattta ctttatgtgt ttgtttctga aacttgcaga atagtatgat 106440
ctgaatagaa tgtatttgtg gttagaaaaa agaacaaaag caaaaacaaa gcaaacccaa 106500
acaactaaac acacaaacag caaataaact acatctacca gatactccat tttagctgaa 106560
aacataaggg attaatcgca cgagaggaag tagattcaat ttaatggcaa gttttttgcg 106620
tcttgtgatc aaatacagtc atgtgccaca taatgaagtt tcagtcaacg acagatcaca 106680
cgtattacag tggtcccata agattataat actgggctgg gtgtggtggc tcacgcctgt 106740
aatcccagca ctttgggagg ccgaggcgcg cggatcacga ggtcaggaga ttgagatcat 106800
cctggctaac gcggtgaaac cctgtctcta ctaagaatac aaaaaaaaaa ttagccgggt 106860
gtagtggcgg gcgcttgtag tcccagctac ttgggaggct gaggcagcag aatggcgtga 106920
acctgggagg cagagcttgc agtgagccga gattgcacca ctgcactcca gcctgggcga 106980
cagagcgaga ctccatctca aaaaaaaaaa aaaaaaaaag attataatac tgtattttgg 107040
ttgtaccttt tctatgttta gatgtgttta gaggcacaaa tgcctaccat tgtgttacag 107100
ttgcctacag tattcactac agtagcatgc cgtccaggtt tgtagcctag gagcaataag 107160
ctataccgta tagcgcaggc gtgtagtagg gtgtaccatc caggcctgtg aaagtactct 107220
gtgatgttgc acagtgacaa agtcacctaa caatgcattt ctcagagcat atccctgtca 107280
ttaaatgatg catgactatt gtgatgggca aggtgaaaga tgatgggggt ttccaagtcc 107340
tgttcagcaa acatttactg agtaactttt aagtatacat gggcccttga atgacagtct 107400
tagtctgggg gttggaattc aaacactcta aactataaat aaatgataaa accattccag 107460
agcatacacc aacataatgt ggacttccag gaattttttt tttatcaacc ccgttcatga 107520
tattacctgg aagcagagtc ctcaaattga agcctaggtc tgccccacct atcttggtca 107580
ccttggagaa cttgctcatc atcttggaac gacttgcctt taaagatgta tgtgcctaac 107640
tgatctccaa ggtctcctgc aaatttataa ttcagttccc tctagtgcaa tgaattaaat 107700
aattatccac ttcagttctt gcccaacaga atttctgtgt aggcttggtg gtcatttgca 107760
gaggggctca ttgtatcaac cagtgtggag gaaaggagcc aggtcctcgg ggggtccctc 107820
ctggccccat ttgcccattt gacagccagc cctttggtca aacaggactg tcagcatctg 107880
cagtaaataa tttttttgtt tttttttttt ttgagatgga gtcttgctct gtcaccaggc 107940
tggagtgcag tggcacagtc tcagttcact gcaacctcca cctcccaggt tcaagcgatt 108000
ctcctgcctc aacctcccga gtagctggga ctacagatgc gtgccaccat gcccagctaa 108060
tttttgtatt tttagtagag ctggggtttc accatgttag ccaggatggt ctcgatctcc 108120
tcacctcagg tgatccgcct gcctcagcct cccaaagtgc tgggattaca gatgtgaacc 108180
actgcacccg gcccgcagta aataatttat tcccttgcaa cattaaaaaa aaatgtggca 108240
cagtgcttta tgaatattat attcattttt atgtatttaa ttttaattta tttatttatt 108300
tatttatttg agacggggtt tctttctctt tgttgcccag gctggactgc agtggtgcaa 108360
tcgtagcttg tgctgggacc atatgagact gggactatcc tggctgtcat tcataaagtc 108420
ttcactgaat ttttaggact tcgctgactg gtctctcttt atgaacttct gtcacattta 108480
gggcctgcat catataaaat gcactgctat gtgttgttct gttagtgttt gtcatcacgc 108540
catcaggggt acacacagct tcagggcagg aatcatcatc acagaccagt agccgagact 108600
acaggcacgc gccaccatgc ctggctaatt tttccatttt tttgtagata cgaggtctcg 108660
ctatgttgtc cagactggtc tggaactcct gggctccagc aatcatcctg ccttggcctc 108720
tcaaagtgct gggattacag gcatgcacca ctgtgcctgg cctgaatatt atatccaaat 108780
aagtgagata ggcttctttt gaaatactgt cctttgtttt tctttagggg atctgacttt 108840
ttccttctct gtgcttgccg tcattgtgtt actggttacc ggccagcctg ttaaccctgt 108900
ggatccccac actttgtttt acgttgaata gcatttatta ttgttctttc ttactaaaca 108960
tcccctttct gaagcagagc ttcagaaatg atgctcagat gtcactcttg ttagcagctg 109020
gctttctgcc ttcaagtgat gcattattgg ggtttcataa cagcattttt ttttctctta 109080
caaatattaa attatgaagt gcaggaaacc acatgaatgt ggtagaaagc aaatgcaaac 109140
acagtgttat ctggaagtgc tagttttgtg attctcctgg tgacagtatc cttcctgtaa 109200
tcaacatagg aaccctcttt acctgtttgc tggtggtttt ctatcctgta tcttcctctc 109260
catttatgct gtatgccatg gccactttgt catgctgaat cgggaggttt gattaagaca 109320
gttgcttggg gactatctct atcaaagttc tgcctcacca caaatcctgg ctgtcactta 109380
caaagtcttc cctgaatcct caggacttca ctgactggtc tctctctctc tctctttttt 109440
tttttttttt ttttttttta aggcagagtc ttgggtctgt tgctaggctg gagtgcagtg 109500
gcaatcttgg ctcactgcaa ccttcgcctc ccaggttcaa gcaattctct tgcctcagcc 109560
tcctgagtag ctgggattac aggcatgcgc caccgtgccc agctaatttt tctattttta 109620
gtagaaatgg ggtttcacca tgttggccag gatggtcttg atctcttgat ctcatgatcc 109680
atctgccttg gccttccaaa gtgctgagat tacaggtgta agccactgcg cccggccctg 109740
agcagtctct ctttatgaac ttctatcaca tttagggcct gcttcttaca gaatgtactg 109800
ctgtgcatta ctctgtgagt gtttgccatc agcacaattg cacatgggtt gcacatggct 109860
tcaaggcagg aatcaaatca cagaccagtg tttcccaagg gtggtctaat cccagtacct 109920
cctgcttccg aatctcttgg atatgtttat taaagttgca gattcagcaa caccaggctt 109980
atgaatcaga agttctgggg atgtagaacc caggaaactc accttagtta acttttgcac 110040
actgaggttt gagaataact atctgaaaat aattgtgcat cctcctcttt gcctcctctc 110100
ccacagcaaa gggtccaggt ctgagcctat ggtaggtgtc caggaaatat ttgcttgttg 110160
acctaagcaa catcaagcca tgagggttgc attccctctt cagttgccaa gctttttcag 110220
gatgtgaggt cagcatattc tctgaacctt tagaaaccca ctttcttcca aatacgtaaa 110280
gtgttcccct agggcagagg ctcttttgga aatctttttt tgtctcttta tcttttgtaa 110340
tcactaactc tgttggtggt aatgacagga gcccctgact aagattggga tagtggggac 110400
atcagctatg aggagctggg ctggagcagc aggctaggag aaagatctga ggataggaac 110460
cggactgtgc taaactagaa gctttatcct tggctcccaa agccacacct gctacccttg 110520
gcagtttatt ctgagtggta tttctttcag ctgttaggcc tcgcaggttg tcagttttgg 110580
tggcagaaga gcggtcccgc tgctgaaaag gatcaagttt agctctagtg gacgcacatc 110640
aaagcaccta cagtgcacag tggtggattc aggatttgaa tccaatgtta gcagactgca 110700
gtggtgacac ttggccctct ccttccgtcc gcctcttgtt ccagcaaggg catgcctggt 110760
cttggatgat ccaggagaga tttgcagggc gttgctgctt ctggtgcacc tcctgaatgc 110820
ccttgctggt ggctccagcc ctggtagatg gaatccaaac agaagaactc acagaagctt 110880
agctagccta gaaaggaacc agcgtggcca tcaggacatt tattagctgt taatctaacc 110940
actaccaaat gcattaacac attttttttg acaacttttt ctcttttatt tggctgttgc 111000
ttagttcagt tttgcttgga gaagttgtgg caatcctgaa ttcagtttgt gtgaaaaagc 111060
aagcaccttc aagcccagtg ttggagaagt atcttctccc aggtctctat tcagttttga 111120
ctaaaggagg tttggcgagc agaaaggtat taccgagtgg attcttctca aattctcatc 111180
taagtgaagg aaaaaagccc agtttgctga agccatgtta agggcacatt aggcttttaa 111240
tatgtgcttc atggagacct tactagattt tcctctgcgt agttctttcc atctgatggg 111300
agcgagggct gtttttgggt tgcagaaggc aagagccagg ttgtcagcta cagaagagaa 111360
aggtgccatt gtctgcataa ttgactttga gcctttgtct aaaaggatgt caggtggagg 111420
agtaatgagg ggcgagattt ttaaaaaatt atagagtaca ggattttagc aaaatgccag 111480
atgttggcat ttctgttttg gaggtcttta gtggtccatg taaactattt ccttgcaagt 111540
aaccatccat ggtaggaaaa cagaaaaaaa tgattctaaa agagcatttg tctagttaga 111600
aactgtgtca cttgtatcgt ttaccgtgag gcatccttga gaggtacatg atttccaaac 111660
agccacctaa atcataggta ctgcttttgg aacagatgta aataggaaaa gcgccagtcc 111720
agtaccccca ctaaagacca tcgttagaaa gctctcgcag tgctttccag cttagaggag 111780
tgtagttccc ttcaggtact taagccagtg ttcggtaaag cagcacccaa aatgcctttt 111840
gttaaatgtg ttctaactcg ttcctcttgc tgatgctatc acaggctaat gattgtctaa 111900
gtccttcaga gaagctgtgt ggttttgtat agctgtgagt aaaaccacac ccattcagga 111960
aatgcaatgt actttcttct aacaggcatc atcaaaacag atgctgattt acatggtagg 112020
tccccttctt tagtgacaat ttgagagctt tgaagggagg catttgccgt gcatcagaag 112080
aaatcagaat taaactggca cacgtgcaca ttgttggagt aaaaaggaaa agcagtgacc 112140
tagagtttgt taccgcacat gctttccctg aaggcatctg caccatcatg atgtcctcat 112200
caactctgca cacacaacta gtatttctgt ctctttctct tcagagttta agctcaatga 112260
tttccaactt cctcccacat gactccagct ggatatcaca taggtgtctt caatttgaat 112320
ctaaacctga ctttgtcatt gtcctacgtt tatgggctcc agggtcacta gctcaccatt 112380
tgttgatgct ggacacctcc tcttcctctg cttcatccct agctcatatg ctggagttct 112440
gccttttttt tttttttgag acagagtctc tctctgtcac ccacgctgga gtgcagtggc 112500
accatctcag cttactgcaa cctctgcttc ccaggttcaa gggattctcc tgcctcagcc 112560
tcctgagtag cttggattac aggtgcgcac caccacacct ggctaatttt ttgtattttt 112620
ggtagagatg gggtttcacc atgttggtca ggttggtctc aaactcctga cctcatgatc 112680
cgcctgccta agcctcccaa agtgttggga ttacaggcgt gagccactgc ccccagtctg 112740
agtttggcct ctttaatatg atagtttacc cactcttctc cactctcggg cccctgttct 112800
gttgcagacc ttcagcatca cttgcctgga ctgctgcagt ggcttccaag aagccccttg 112860
cttaaagtct tttctttctg tgttccattt attctactct tttgagaatt ctcatatgaa 112920
agaaagggtc tgattgaatt actcctacac ttgaaaatcc ttggtagtat gtggaaatat 112980
ggaaaagtac tcataatcta atgtgttaaa agaaaaactt tagacaaatt aaatttaaca 113040
gagtttaatt cagcaaagaa ctatttgcaa atcaggcagc tcctctctac tcctttcctc 113100
ccgaactaga atagattcag ggcatttctg acatgctgtt gtgtggttgg agaggattta 113160
tagacagaaa aaggaaaacg acggacagaa aacagaagtg aggtacagaa acagccagat 113220
tggtttcagc tcagcgttcg ccttatttga acagggtttg aacgataggc tgcctgtgat 113280
tcgccgaaac ccagagattg gtacaagaat aggttacagc ctgtttacac atccaggtag 113340
gttacggttc actgcatgcg gagaaacctt taggccaaac ttaaaatatg gaagaaggca 113400
gctttcggct aaacccaaca aatgttaagt ataaaattca tatttcaaaa ttgtgcaaac 113460
acattgatta caaagcagtg acaaaaatct atgcctatcc acaaaggcta gaagtaaaga 113520
aaacaagaat gaaggtattt ttaatattag ggcaattcat gtgtgtgtgt gttttttaat 113580
actcctttgg tagcaaatga atatggtgaa gtaaaatgaa taattgaaag gattttgtta 113640
gctttctgct cctgataagg taaaatgtga atttcactgc atggcctcta aggcccctag 113700
gaattcctta tcaacttacc atttaaatct catctcccgt gactcccatc ccttccatct 113760
ctccatataa tatttgtttt cttcttaaac atactatgta tataataacc atgcacctgt 113820
ccctgttgtt tcttctcgca tgagactctt gttctctgcc tggtaaactc ccactcattc 113880
gttgaggcct aattgaaatt cctggccaag catggtgtct cacatctgta atgtcagcat 113940
tttgagaggc tgagggaaga ggatttcttg agcccagaaa gtttagactg caccattcca 114000
ctccagcctg ggcaacagat agagagctcg tctcaaggaa aaaaaaaaac aaaacagaaa 114060
ttatcctctt gctgtgttac cgctattata ttgcaatttt ctgctcatat agctatcttg 114120
gtaaatgatt catgaagaca gaaattgact tatcttaaac cttgtattcc aagtgttaag 114180
cccattcctg catataatac agtttaataa atatttacaa aggtaagaag aaaggaaaga 114240
gcccatttag aaatacagaa ataatccttc aggtaagata ttaaaaatgt ttttggataa 114300
gcttagtact aattactatt tcataaaaat tacaaaaata gatgtttttg gttaaacagt 114360
ttttacagta atagttggat tcagcctcac atcatttaaa ctaaactact ggcgtatatc 114420
tttggcatta gaaaattcta acatcagata gaattgcttc agcttcactg taagccatat 114480
ttatgaagtt actaaaaacc atttttttaa actgttttat gtcatgcata accatgtcgg 114540
ccaaatcaga aatccaaata aatgacacat ccagttctgg ccacattttg tgaatatctg 114600
gtattttttt cttaagggaa tttaaaaaga ctgggtaaca ttaaagggtt gatgtaacat 114660
tttcaattct gaaaggctac tctgctctag gaatatactt gttactattt tttttttcat 114720
ttctaagaat tctgtttggc taaaatacca aaagagaaaa aaataacttg gcttaaataa 114780
aatgaaaagt catctccaaa attaattcgg ctcctcaaaa gttctttcca aaggaaggaa 114840
taggatgcta tttaatatta catgtcaaaa acaccactaa aaagaaaatc atcatttgta 114900
cgtgtgacaa ggaattcaga atggaatttt atgaaggcta gtgtgtgagg cacgctgctc 114960
acatctttta aaataatatt ttgatatcgg ggaagattat ttaatactat atattatttt 115020
atattatata tgtatgcata tgtgtatata catatataaa atagagtttt ttcctattaa 115080
tgctttagag tcaataagtt gtaatgggga atttcagttt gagatttgtc attttttttg 115140
catgatagcc ttgcccagcc ttcagttttc ttgtttataa agtcatgcca aaaggtgaac 115200
tgtcactgga ttaactaatt aagaaattag tcagtcacta acatttattg attgaccact 115260
gattggaaac attaaatacc cacatcattt tttagcattt catgtaagtt gatccttgtc 115320
tgttttgcag agtaaagaac cttagctgaa tttcattttt gtctgtcctg atctttgcat 115380
tcatttaaaa acctgaccct tcagctgttt acaagatcca tcatgaaata taccatggct 115440
aaggtgaatg tgcagactcc cagtttccct ttagctattc tgttgcacta gccatggggt 115500
tgcaaacttt tttggtgact gttacagttc attcatcagg aggtactgac tatattttgt 115560
tgcactttca tgagagccag ggctcagaag catcctaagt acctagtgac aaaaactcag 115620
gaaggcaatt agactatgac gcttttcatt acaacctaag gtgcctctca atatagtagg 115680
tgcttatgtt gaactgccct ctgcagactg tatgtgtggg tccatgtggt gatattgtgg 115740
ctgtaccctc tccaaggttg cctagtgttg gctgtagcag gaaaggaagt gtctgtaagc 115800
aatagtagct tcaatgagga aggatataaa agagaagtga actagtcctg aaatcttaag 115860
gatctacata cagaccagag taccttgatg gatcccaaag ttttatttta ttttattttg 115920
tttttgagat ggagtttcgt tcttgttgcc caggctggag tgcaatagcg caatttcggc 115980
tcactgcagc ctccgcctcc tgggttcaag agatcttctg cctcagcctc ccaagtagct 116040
gggattacag gcacctgcca ctacacccag ataatttttg tatttttagt agagaggggg 116100
tctcaccgta ttggccagga tggcctcaaa ctcctgacct cagatgatcc acccgtctca 116160
gcctcccaaa gtgctgggat tacaggcgtg agccactgcg cccggcctta ttttattttt 116220
ccagcattat tgagttatga ttgacaaaat ttgtgtacaa cacgatgctt tgatatacat 116280
atatattgtg aaatgtttat tatcatcaag ttagttaaca ctttcatcac ctcacatagt 116340
tattttttct tgcatggtga gaacatttaa gatttactgt ctcagcaaat ttcaagtgta 116400
caaatatcat tattaaccat agtcactgtg ctgtatattc aatccccaga tctcaaagat 116460
ttaaaatcta gccctgagac aactgattac agccaccata tgttttctta ggtagttcac 116520
aataaatagt tataatgctg ctgagaaaca gtatgatgtg ttgaaaagtg taggttcttg 116580
aggcaaactt cctgggtttg aataccgaac ttccacttaa tggctgtgta atgttgagca 116640
agtgacttaa tctctttggg tctcagttta tcaatccatg aaataagaaa aataaaacag 116700
gccaggcacg gtggctcacg cctgtaatcc cagcactttg ggaggccatg gtgggtggat 116760
cacaaggtca ggggttaaga ccaccctggc caatatggtg aaaccccatc tctactaaaa 116820
atataaaaat tagccgggcg tggtggcagg tgcctgtagt cccagctact tgggcgtctg 116880
agacaggaga attgcttgaa cctgggaggt ggaggttgca gtgagccgag atggtgccac 116940
tgcattccag cctgggtgac agagcgagac ttcttctcaa aaaaaacaaa acaaacaaac 117000
aaacaaacaa aaaaacctaa atgagtcttg atgcacgtaa agctttcaaa aaatggtagc 117060
tgttattatc ataccacttt catggaattt cgttagttac tcagtttgtg gtaaaatttt 117120
tccagtgttt attcttcatg ccttcctaca aacttggttt aggaatttac actgttaggg 117180
gaaacatgta ggtgaaccca gctagggaag gcgaagcaat gctgtgggaa cacaaaggag 117240
tgggatattt agtctgattt gggagtggtg aggacttgga ggaagcatca gagctgactt 117300
ggaagaatgg ctaggattcc acctgacaga gctgggagca aggcattcca cacgggaggg 117360
cgtgtgccca aaggtgtgga gaagggagag tgcagagcag agcatatttg aggaaagctg 117420
tggaccagtt tgagcccagg gttaaggtgt gtgaggtgga acagtgggag actgggagga 117480
agatagtctg atttaatgat aatgatgata acggtgagtg tgaactattc actgagtggt 117540
gccatatatc agattctgtg gttggggctt tacataaatt agctctgatt acaactccct 117600
tcaacatagc tatccacatt ttacagatga gaaaatggga ttaattccat tttttcttaa 117660
gtggcggaga gccactgaag gttgttgaat aggagagggt catgatcact cttagcagga 117720
atttacttat ctgctttttc acttccctgg agtggtagac acgtcttttg ttttgtttaa 117780
gagacagagt cttgctctgt cacccaggct gagtacagtg gtatcatcat agctcactgc 117840
atccttgacc tcctgagccc aggtgatcct cccaccccaa cttcccagag ctctggaatt 117900
agaggcatgt gccaccacac ctggctcatt tttaattttt tttttgtaga gatggattct 117960
tgctatgtta cccaggctgt tctggagccc tgtgttccag caattctcct gctttggcct 118020
ctcagagtgc tgggattatg ggcatgtgcc accacacata gccttggaga tacatcttgc 118080
accatcctgg gctccccaga ggagtggtat tagactgtca gtatggtgaa tactccataa 118140
atactggtgg agtctgtttt caaagcttcc ttaacaaaac tctggaaaca tgttttgtac 118200
aatttccttt ttaaagaaga aataaactgg ttaagttact gagcaactcc tttttgcctg 118260
tgcatgtttc atctcatttg atccccatag gaaatcttaa aggtagagag tgtaattttt 118320
gcatttcaat tatatgttat taatattata atggatgagg tcactgggac tgaagaaagt 118380
aatgctgctt ggagatggta aagctgggat tcaatctgtg gctccctcac ccttggtctg 118440
tagtcggcca ccacccctcc ctctattgaa cctctctttt attgctgttt tccagtctcc 118500
actaagtatt tcttccactg gtttaagtcc acgttgctaa gcaagtacac agttgctttt 118560
aaggaaacga aagccccaca aggacccagt ctactttgca gaggttaaat ggaaatagat 118620
tattttcaat aatctgtcct caggaccaga attcttctaa atgatgctgc tggcagctgg 118680
ccatctctgg gagcccatca gacaaaccac ttgtaggagc ccagcatcct gcattgggtc 118740
agaatgcaaa gtcaactaac tcttcacagt agatgcagtt tgggcgtgag tacctagcag 118800
gaaccctaga tatttggggc aagcactttg cttcttccat ctggtggaac ccacgtttat 118860
tatctaaaag acacatggca acaggcaatg cagtgtttgc ttccaaagac agcctggaat 118920
ttggaatgac atttagtgaa aggggaaagt tcaatttcag ctatcaaagg tcatggccag 118980
tgaacctaca agcacatatt atgtaaattt ggcccaaatc tgtatttatt agcttgaaca 119040
gttttggagt ggttatctgc tctacaaaaa tgatctaccg ttaagagtct caaaaatatc 119100
aagtctgctt gatgcattta aatcaggaag cgtaaatatt tggcatccat gctagtgctg 119160
attttcagag gctttgctca cctgcagctg tgctcacttt gcgaaaatgg acatggtgac 119220
ctctactttc ctggtgagtg gccacgtcag tatcatccct tcccgttcct ggcaccactc 119280
tcacccactt tggagagcca gcatagagca gcacgctgtg tctcagggac caggctatcc 119340
atcagatacc ctactctgaa agtgtcctta atttgatttt taaaatatat ataaatatat 119400
agtgtgtgtg tatacacaca cacacacaca cacacaccat aaaatttacc ataaatttac 119460
cattttaacc tttttttttt tttttttgaa acggagtctt gctctgtcgc caggctggag 119520
tgcagtggca tgatctcagc tcactgcagc ctccgcctcc tgggttcaag caattctcct 119580
gcctcggcct cccgagtagc tgggactaca ggcgcatgcc gccacgccca gggaattttt 119640
gtatttttag tagagatggg gtttcaccat gttggccagg atggtctcga tctcttgacc 119700
tcgtgatctg cccgcctcag cctcccaaag tgctggggcg tgagccacca cacctggccc 119760
agtttaacca tttttaagtg tacaattcag tggcattatg tacatttcca gtgtagtgca 119820
atcatctcca ctatccattt ccagaacttt ttcatcatcc cgaacagaag ctctgcattc 119880
attagacaat aacactccat tctctcctcc cagcccctgg taacctctat tgtacactgt 119940
gtctctatga agtttcttat tttagggacc acatggaatc atacaatatt tgtcctttta 120000
tgtctggccc ataatttaat ttttaataac agtgtttcaa atatactgtt cttttccaaa 120060
gtatttgtta tcaatacttt attatgtcag taattatcaa taagttctca ttctaatttc 120120
agaaactggg ttgtattgga atatgggcat agagaagata cagatttttt tttcttctta 120180
ataactgaag agaataacat ttatcaaaca aacgatcgaa ctctttctga gacatagttt 120240
catgtgcctc tttggagttg atttcccctc actttatttt aactcctatt tggcccgaat 120300
tcttctcaga atttctgcaa gcaggctcat agtcctgcgt tcttctcttc tctttttttt 120360
tttttttttt tttggcaggg tctcactctt gtctcccagg ctggagtgca gtggtgcaat 120420
ctcagctcac tgcagcctcg acctccgggc ctcaagtgat cttcctgcct cagcctccca 120480
agtagctgag attacatgtg tgcacgacaa cacctggcta atttttgtat tttttgtaga 120540
gacgaggttt catcatgttg cccaggcttg tcttaaactc ctgggctcaa gcagtctacc 120600
cgtcttggcc tctcaaagtg ctggaattac aggcgtgagc caccgcagct ggccaggctt 120660
acatttctgt agtgcctgtt aggaagagtt cagaattttt tagacacagg catagctcag 120720
agatattgtg tctttttttt ttttttttga gttgggagtc ttgctttgtt gccaggctgg 120780
agtgcagtgg cacgatctct gctcactgca agctccgcct cctgggttca agcctcccaa 120840
gtagctggga ctataggtgc ctgccaccat gcccagctaa tttttgtatt tttagtagag 120900
atggggtttc accatattgg tgaggctggt ctcgaactcc tgaccccagg tgatccaccc 120960
acctcagcct cccaaagtgc tgggattaca ggcatgagcc actgtgcctg gacactcaga 121020
gatattttgg gttcacttat agaccacagc agtaaagcaa gtattgcaat acagcaaatc 121080
acacaaattt tttggttttc cagtgcatat aagttatgtt tacaccatac tatagtctat 121140
taattatcca ataacatttt gtctaaacaa aagtacatac cttaatttta aaatgcttta 121200
ttgctaaaaa ctgttaacga tcatcttcat tgaaccataa tcgttttgtt ggtaaagggt 121260
ctttacgttg atggctgctg actgatttag ggaggtggtt gctgaaagct ggggtggcgg 121320
tggcaatttc ttaaaattag acaacaatga cgtttgccac atttattgac tcttcctttc 121380
atgaaagatt tctctgtagt atgcaccatt gtttgagagc attttaccca tagtagaact 121440
ttcaaagtta gagtcagtcc tctcaaacct gtcactgcat caattaagtt tatgtaatat 121500
ttcaaatcct ttgttgtcat tttaacagtg ttcacagtat cttcatcagg agtagattac 121560
atctcatgaa accactggtt tttttgtttg tttgtttgtt tgttttgaga cggagtctcg 121620
ttctgtcacc caggctggag tgcagtggcg cgatctcggc tcactgcaac ctccacctcc 121680
caggttcaaa caattctcct gcctcagcct cctgagtagc tgggactaca ggtgcgcacc 121740
accacgctgg gctaattttt tgtattttta gtagagatgg gtttcacaat gttagctgtg 121800
ttagccagga tggcctctat ctccggacct tgtgattccc ctgcctcggc ctcccaaagt 121860
gctgagatta caagcgtgag ccactgtgcc cggccatgaa accactttct ttgctcctcc 121920
atagaggcaa ctcctcatct gctgaagttt gatcatgaga ttgcagcaat caattcagtc 121980
acattttcag gctccatttc taattctggt tctcttgctg tttccacctc atctgcagtt 122040
ccttcctcca ccgaagtctt gaaaccctca agtcatccat gggggttgga atcaacttct 122100
tccaaactga tgttcatgtt gatattttga cctcttccca tgaatcaaat gttcttaatg 122160
acatctacaa tggtgaatcc tttccaggag gttttcaatt tacttttccc agatccatca 122220
gaggaattac tttctgtggc aatgatagcc ttacagaatg tatttcttaa ataagaagac 122280
ttgaaaataa aaattactcc ttgatccatg ggttgcagaa tgggtgttgt gttagcaggc 122340
gtgaaaacga catgaatctc cttgtatatt tccatcagag ctcttagatg agtgacgaag 122400
tgcattgtca ataagcagta atattttgaa aggaatcttt ttctgagcaa ttaagtctca 122460
acagtgggct taaagtattt agtaacccaa tgtgctttca tccaggcttt gttgttccat 122520
ttctatagca ctggcagagt agattcagca taattattag ggctctagga tttttggaat 122580
ggtaaatgag cattggcttc aactaaagtc actagctgca tttgcccgta acaagagagt 122640
cagcctctcc tttgaagctt tgtagtcaag cattgacttc tcctctctag ctatgaaagt 122700
cttaaatggc attttcttcc aatagaaggc tgctttgcct acgttgaaaa atctgtagtc 122760
accttcatca atgatcttag ttaaattttc tggataacct gctgcagctt ctacatcagc 122820
atttggagaa gatttctttc cttaaatctc acgaaccaac ttctgctagc ttcaaacttt 122880
tcttctccaa gttcctcacc tctctcagcc ttcatagaag tgaagagagt tagggccttg 122940
atctggatta ggctttggct taagggaatg tatggctggt ttgcttttct attcagacca 123000
ctctaacttt gtccatatca gcaacaaggc tgtttcactt tcttaccatt gatgagttca 123060
ctggagtagc acttttaatt ttcttcaaga acttttcctt agcattcaca gcttggctaa 123120
cccttcagtc acaagaagcc tggcttttga catatgtcag ctttcaacat gccttcctcg 123180
ctaagcttaa tcatttctag ttttcttatt taaattgaga ggtatgtgac tcactcttcc 123240
tttcacttga atgcttagcg gctattttag ggttattaat tggcctaatt tcaatattct 123300
tttttttttt tcttttttga gacagagtct cgctctgtca cccaggcttg agtgcagtgg 123360
cacgatctct gcttactgca agctccgcct cccgggttca cgccattctc ctgcctcagc 123420
ctcccgaata gctgagacta caggcacccg ccactacgtc cggctaactt tttgtatttt 123480
tagtagagat tgagtttcac catgttagcc aggatggtct tgatctcctg aactcgtgat 123540
ctgcccacct tggcctccca aagtgctggg attacaggcg tgagcccccg tgcctggcca 123600
acttcaatat tcttgtgtct gaggaaacaa ggaggcccga gaggagggag agagaacagc 123660
cagtctttgt agcagtcaga acacacatga catttactga ttaagttcat taccttatat 123720
ggggtgtgtg gttcatggtg aacaaaacaa ttataatagt aacgtcaaag agcactgatc 123780
tcagatcacc ataacagata taacagcgca aaagtttgaa atactgtatt accgaaatgt 123840
ggcagaggct caacatgagc acatgctgtt ggagaggtga tgctggtgga gttgcttgac 123900
acggggttgc cacagaactt caatttgaaa aaaaaatgca gtatctgcaa aggacaacaa 123960
agtgaaatgc aataaaatga gatgcgcctg ttgcatcttt caactgatgt gtcctttctt 124020
ttcattaaaa aaaaataacg ttctgtccat ctgcctctgt ccaacaacag gcagtcacat 124080
gtgatgccta ctgttggaga attggtgaat cataggcctc cacttctggt gctattactc 124140
agagaagaag tatttctttc tgcatagaag gaaacattgt aattttactg cagcaatgaa 124200
attgtagtag aggtgaacat aattcttcta tttacatctt taatgagcca caattaaaag 124260
tagtgagttg gcatgtcaga gtgaatgtgt tattttcaga tttctgttag aacaatggct 124320
gctgctggtt gaagctgcac ttccctggcc ccttggagct ccaaaagcct taagaaagaa 124380
acccaggggc cgggcgcaat ggctcaggcc tgtaatccca gcaccttggg aagctgaggc 124440
aggcgaatca cctgaggttg ggagttcaag aaccagcctg accaacatgg agaaacccca 124500
tctctactaa aaatacaaaa ttagccgggt gtggtggggc atgcctgtaa tcccagctac 124560
ttaggcggct gaggcaggag aatcgcttga acctaggagg tggaggttgc ggtgagcctg 124620
tgtctggagt tggttccttc cgataggttt gtggtcttgc tgacttcaag aatggagcca 124680
cggaccttca cagtgagtgt tacagctctt aaagatggta gggacccaaa gagcgagcag 124740
tagcaagatt tattgtgagg agcgaaagaa caaaccttcc acagcgtgga aggggacccg 124800
agcgggttgt ctctgctggc tggcgtggcc agcttttatt cccttatttg tccctgccca 124860
tgtcctgctg attggtccat tctacagagc actgattggt ccattttaca gagtgctgat 124920
tggtccattt tacaaacctc aagctagcta cagagcgctg attggtgtgt ttttacagag 124980
cactcattgg tgcattttac aatccccttg taagacagaa aagttctcca agtccccact 125040
cgacccaaga agtccagctg gcttcacctc tcaataccac ttctgcattt aattatagcc 125100
accgactagc tgcactatga tattaatctg ggctacttgc ttaggaacct gcagatgggt 125160
ttccataagc tagacattgc tgcctgataa atgactgtgg gatacaggtt ttcctgatga 125220
ggtagtaaag ccacatattg gaattcattt aacagctcga caacataatt tgtaaacatt 125280
tctatttagt cacgtgtact cagcaaaaat gtatactaaa gtgtttacca tatacttggc 125340
attgaaggga attataatga aatatgttga tcttggtcat ttataggtgt tcccaccact 125400
gtgatgtgtg catgcattgt gggccaggag gttttatctg gaagctagtg acacttcagc 125460
gtcaaggcgt ctcgctcctg caggcccttt gtaagaccct gtacctaatt ttatgttgat 125520
aattttgtgc agtttttttt tttttttttt tttttgaggc agcgtctagc tctgtcatcc 125580
aggctggatt gcagtgttgt gatcttggct cactgcagcc tcaacctccc aggctcaagt 125640
gatcctccca cctgagcctt ctgagtagct gtgagcagat acatatgcca ccatgctcag 125700
ctaatttttg tatttttttg tagagatggg ggtctcacta tgttgcccag ttttgtcttg 125760
aactcctggg ctcaagcgat cctccacttc agcctcccaa agttctggga ttacaggcgt 125820
gagtgaccat ggctggcctt tgagatcttt tcttaaagac cctaacaccc catacacact 125880
cctctacccc ttgactagtt ttataaactg cagacctcac agactggatc cacccctgat 125940
tatgaatatg tttaaactgt gcatatgtat gcattaatta aaacatattt atttctcttt 126000
catactagta tgtgaaattc caaaaaatct gctagcccac aaattaggaa aattaaaggg 126060
ctatgcctac ctctgccagc tgtttccaag gaaatttata tcttggacat ttggcagata 126120
ataatatcat gtttgactga tagtgatcat gtcctaaatt tcccaaactg atgagtcaca 126180
atcgtgattc acatatttct gggaatcgcc ccccaacaac ttgcgatttg cctggcgtag 126240
ctgtagtata tcagagtttt ttaggtgttt agcagaactg aactatatag cttcttgtcc 126300
catgccaatt caagaaaatt aatttaatag ctattttatg aaacattttt tcctaactcg 126360
acatggatat tttaaggtga ttttccctgc taagaattca cttgttatag gtgactctaa 126420
ttggagaaac agctgttgac ttctagtgtg ctcaattagt ttctttcttc ctttttcttt 126480
ttttatttta ttttatttat tttttattat actttaagtt ctagggtaca tgtgcacaat 126540
gtgcaggttt gttacatatg tatacatgta tcatgttggt gtgctgcacc cattaactca 126600
tcatttacat taggtatatc tcctaaagct ttccctcccc cctcccccca ctccatgaca 126660
ggccccggtg tgcgatgttc cccttcctgt gaccaagtgt tctcattgtt caattcccac 126720
ctatgagtga gaacatgcgg tgtttggttt tttgtccttg cgataatttg ctgagaatga 126780
tggtttccag cttcatccat gtcccaacaa aggacatgaa ctcatccttt tttatggcta 126840
catagtattc catggtgtat atgtgccaca ttttcttaat ccagtctatc attgatggac 126900
atttgggttg gttccaagtc tttgctattg tgaatagtgc cgcaataaac atacgtgcgc 126960
atgtgccttt atagcagcat gatttataat cctttgggta tatccccagt aatgggatgg 127020
ctgggtcaaa tggtatttct agttctagat ccttgaggaa tcgccacact gtcttccaca 127080
atggttgaac tagtttgcag gcccaccaac agtgtaaaag tgttcctatt tctccacttt 127140
cttccttttt caaagagttc ctttattatt cccaggccgt cgttaggtgt aaaagctaat 127200
ttagtttaga ttatttttta aagtgcacct ggcattcaag ctatgacatt tcctgttgaa 127260
acagcactgc tatgacctgg gaagaaaaga tcccaagaaa atataactga ggaatcaaat 127320
atttgtctgt ataaaaggtt tcatattaat tcatgatacc atttattagt cacttacctt 127380
ttatgttagt agccataagg aggtgtgatg gcatagacta ttcagggcga atgacagttg 127440
tcatgggcag aaggtgccca tgcatcaggc agagcagggt gaccacaaag tggggagtgg 127500
ccaaatatac tttgtcctac tcaagacatg agggcctgtc ccagtggctt gcttgagaac 127560
aaagctcatc ctgatgactc agcagccaca gtgaagggct gcctgggggc tgggggagaa 127620
acaagtaggc agatgaggtc cagttggaaa ctaaattgct ttgggaggag gagagtggtc 127680
acacaatgta ggtttcagtt ccggctgcac tgctaatttt gtaaccttgg gaaagttacc 127740
aacctctctg gaatctcagt ttcctcccct atgaagaaga aagcagtagc ccagatcatc 127800
cttggaggtt ccttcccttc agctgtgaca ttttgcattt gaaagagtaa gagaagtcac 127860
aggaccatgg gaaaggaaaa cagaaatgat gtaagggagg caggtcatgg ggagggtggt 127920
caggaacaca ggttggaagt gcccgtggtg tcaattcagg tgttcggtga tctccacggg 127980
cgagtgactt ttattgggag aactgtgcac tgcctgaggt tagggttgtg ctctggggaa 128040
accggaacct tgaaaacacc ttgtagggag ccgcgtttcc cttgcacgga ctgtgctgcc 128100
tgtgcttccc cagcacagtg ggcgtcgtcg ctttgtgttt gtgctggctg ctgtgcgggg 128160
ttgcctgcct ccccagccca cacctgctca gccttcctcc actcatgttt tcaggatgct 128220
tttggatgct tctggctaca gtggattttc cttctccttc tgaagccctt ttgaaattat 128280
ttctctgcag attcagacat atttatttat ctggtcaatg tcctgcctaa agaatcagat 128340
aacgactgtg tttttgcctg aactcacaca tatgaatgag cttttgtaag cggcagcagc 128400
agtgtaggtt tagttggagc tgtctgagcc cttgtcaggt tgctacttag ttgtttagtt 128460
agctctcgtt gaacttctgt cacatcctca gtttctgggc agtgtgtaag aagagctcct 128520
tctctctaga ccagtggtcc ctaacctttt tggcaccagg gactggtttc atggaagaca 128580
gtttttccac agactagggt ggagcggggg atggttttgg gatgattcaa atgcatttat 128640
attcattgtg cactttattt atattattat gttgtaatat ataatgaaat aattatgcaa 128700
ctcaccataa tgtagaatca gtgagatcct tgagcttgtt ttcctgcaac aaaacggtcc 128760
catctagggg tgatgggaga cagtgacaga tcatcaggca ttagattctc ataaagaggg 128820
tgcaacctac atccctcaca tgtgcagttc acaatagggt tcacgctcct atgagaatct 128880
catgccgttg ctgacctgac aggaggcaga gctcaggtgg taatttgaac aatggggagt 128940
ggctgtaaat acagatgaag ctttgctcat tcgcctactg ctcacctcct gttgtgcagg 129000
aggtctgtag cccaggggtt gggaacccct gctctagagc ttaataatca actggtggag 129060
accagtgcaa ttgtaaacaa aagtgacaaa acgatagtaa taatgccaat ggtaatgaaa 129120
gctacagaca ttttcagagt gctgtgtctc caagtactga gctgagcact ctgcactcat 129180
gaaatatgta tcctcctcac acacacacac gcaaaataaa tgtttaatgg aatattgatc 129240
aggaaaaaaa caaccagtaa gcaaagtatt aatacatgct acaacataga tgaacctcaa 129300
aacatcatgt gaattgagag accacatact tcaatttcat ttatatgaaa ggtccagaat 129360
agacaaatcc atagagacag aagttagttt gggggttgca gaggccggag gtgggagagg 129420
aatgcagagt gactgctaat gtacacaggg tttctttttt ggagaagaaa atctaaaatt 129480
agattgtgat gttggtttta caaaacagtg actatactaa aaaacatttg agttatacac 129540
ttgagttata tgtaaattaa atcttaataa agctgttttt ttaaaaataa atgtttaatt 129600
ctcagaaaca accctatgag gtagggagta ttatcctcct acagatgaga aaaccgaggc 129660
ccagaaaaga ggagaacctg ctcaagatta catataaggc atatgtagga ttaacttttt 129720
cattacagag aaatccatgg tagtgcttgc taagtaaatg ctaaatctat tgattgcatg 129780
gatgccagaa ctagatgggg ttagtttaga tggattaagg gaggaagtgg tttaaactgt 129840
gttttctaag aagaaagagt agtgattgta taaagaagac aaaagggcat ttcaagctgg 129900
agataattgc ttgtgagagt taaacatcaa gaaaccagac atctaatagg tttgttcaac 129960
tggagtgaag aatagccttt catatgacag gtaggtaatc agaagcaagt gaatttagag 130020
ttatattgtt agctgtagtg cgggcttgct gtaattagta gcaggccgac accttgtaac 130080
atctctctgg agtgtaaaga catatttcta acagaaatgt gttagtctgc aaagcaaata 130140
aggtgcaagc gtaaatgtcc tttttccttg gactgtcttt accgaatgac atgagcttca 130200
cacccttgcc ttgagctgtc actatcattg cttcactttc tattaattag ctcggagcct 130260
tggttctata gtcaacttga aactgctctg gacatatttg ctctaatcct cctggacaac 130320
ctgtgagatg tgccttttcc tacacttctg ccttgccctg gcagccacat gacacactct 130380
cgcaaggcag gaacctcagg gaggggaggt ggcggtgtct gttggcaagt actcagctcc 130440
ctttgaggct gcagatagta ggcattggtt aagagtttaa acttgggcaa gaactggaag 130500
caaattggga ggacctggaa ttgtgggtgc ttggggaaaa acattacaat gaggactcat 130560
atgggtcgtg tggtcatgtt tgtttcaagg gctttccctt ccaaaactgg aaaagaaaac 130620
tgataaaaca aacattgggt ggcatttttt tctaggcttg tcaatgggtg acttgtttgc 130680
cgaattaatt aaataattaa ttaattacct tgtttataat cttccttgtt ttgaaaagat 130740
ttatggcagt gccttaaatc tgtaaatcta cccaacaaga gaatcttatg aagtaaacaa 130800
gttaacaggt gaaacatgcc tccttttaaa tgtttcttta taacaaaatg accatatatc 130860
aataacagac tgtaacaatg cgtagcaaat gtatttatgt ttctcatcta ttttccactt 130920
tcaaaaatgt gcttttccct taaactccaa attgtcttaa caatttcaca ttttcatttc 130980
tttcttttct tttttttttt tttgaggcgg agttttgctc ttgttgccca ggctagagag 131040
caatgacgtg atcttggctc actgcaacct ccacctccca ggttcaagcg attctcctgt 131100
ctcagcctcc caagtagctg ggattacagg cgcatgccac cacacccggc taattttttt 131160
gtgttattag tagcgacgag gtctcgaact ccagacctca ggtgatccat tcacctctgc 131220
ctcctaaagt gctgggacta cagatgtgag cctggcccaa tttcacattt tctaggttct 131280
gtagaggttc atgtttgtgg catggtaatt cttgtttttt gcattttttt tttcttaacc 131340
cccctcctgg cttttggagc actataaact tagcactggt ggggccacat cttgacagcg 131400
agacccttac agcccccaac cccgcatccc agtggggctt catgatctgg ccctgctgtg 131460
ctggtggcat ggccccctcg gggcttaagt gattctgggt cattgacaag aatcttgcct 131520
gtgtgaattc aaatcaaaac tttggagagc aaagattcag tgttttcctt ctgcctaaca 131580
atctcatgga aagcacagtg gtacctagca tttagctcat gtgttcattt agcaggctct 131640
aagtcatctt gtcacatgtc atcctcatgt cagctctgtg tggtgttgtc gacccacgag 131700
caaacgttgc aaggtcccct ttagggtgac aaggctgatt caggatgtgt ctcactgccc 131760
caggaaggat gcctctaaca tgcggaacat ggtgccagtg gctgagggga ttagttgggg 131820
aagaagagtg aatagggaaa ggaggttgtt acatgatcca cccctcactg gccagagagg 131880
aaaaggaagg catctcatta agagcattag ctgtagcctc tcatttaaac ctcctcacta 131940
ccccatgaag taagcattat tgcttttgtt ttacaggtgg tgtgagacaa aagtgaagga 132000
atgagactaa ttaataataa gaatccatgc cccaccatag ctacgatgca gtggagcatg 132060
gattctaaac cagctctaac atcacatgcc ctattttcga gcactagtgg cttatttctg 132120
agctcttctc ttcctctttc ctgttgatgc ttgagtttta gttatatcat ggcaaattga 132180
aaaattcttc aaaaaacata cagaggaaat aaagtggtgg gatctgaaac aaaactctta 132240
ttgattagcc attctaatga agatttgtgg ctgagatggg agttttgcaa tcaccttggg 132300
atttcagaac cctgctttta ataattagaa ctaaagaagg gagagtccta tagaagtgtg 132360
ggtcataaaa ccaaggatgt gaatgaggag tggcaagaca ggtatcctgg agactttatt 132420
tcagtgagac ttctggggca gagttgggac tgatggggga caagtcagct ttggaatgat 132480
acagaatttt tggctgtgac acctgtgtga ttttagtgct ttgcaccata tcaagagctg 132540
agcagagtgt ggcaccaata ttcaagggac tcaaggggca aatataggtg tcagtgagtg 132600
aaagcagata gcgagatttg caatgcagtg tccaggagtg tccatctttc tagacccatt 132660
tctacttata agatcactgc ataccctgtg aaacattata ttcatgaagc cacagagttt 132720
gagccactgt gtttacgctg caagtggaag gagagtgggc atggagtcag aaagactcaa 132780
gttcaaatcc agcctccata atttatcgtc tttaagaccc tgggaaagtt gacctaagcc 132840
tctgttttct cagctttaaa acatgaataa taatcctgcc tcacaggact gctgcacata 132900
cggcagtcag cgcagtgcca ggcacacacg agtgtcttat tagttattat tattatcaac 132960
aaagagcata ggtgatcctt cttatcatga ttataaaaac tgtggcttac caatgaaagg 133020
gtccttcata agccaacaaa gagacatccc tgaaattttc actatagcag aaatgcaaat 133080
tattactggg tacatttctg gcagacacat gagccattta cataatgaaa cctctctaat 133140
attatttcta ttaatagcaa tacttctgag tatcaatctg accattttgt atttagaatc 133200
attctctctg tgaacagatt ccttttattg ccatgtcgtc ttaatatctt ctgacaagta 133260
tcattatctc tttgctgcat attctaatgt ttatgattgc atgagtttta aagtgttcat 133320
ttactacctg agaacctcca ttttaataat gcattgcttt aatgttggtg tttgggaggt 133380
aaggttgttg cttattttct cagatgccga ttcacagttg agcagatgat gacttgcagg 133440
aggctctctt gacctgtcat gctctgatat catcaatgca ttggagtggt cacttctgtt 133500
agcttttcct ccatgaatcc cctgttgatc agcccactaa gtgactcagc atatgtctgt 133560
gcacaccttt ggaccacatt atcatccact cacttaggcc cttgaatttt tttatgggta 133620
tgtgggctat attgctaagt gataaggctg gttctgtaaa tggacctcgc aacttcagca 133680
taacaacggt atggctagtg tcctcctcta ggagggactc cccttgaggg cagatacagg 133740
tttttcctgt ttgcctcaag agagtcatac aatgcagaag tgcccaagtg aatgttgggt 133800
gaatcagtga gtgtaagagg gcacccaagg gaatgcccac agttggaagg aagttgcctg 133860
agaggaggag tcctcagacc cattctagct ttgtgattct gcccgtacag acatgattta 133920
tatgacagga aaaacatggc aggcccttgg gaagcatttt catcttaacc tttataatat 133980
ctaataaatg ggcaagatgt taaaaaaaat tgccctttcc agaagaaggt tatacagact 134040
ctaagaaggc aacattaaga aatttttgaa tttttttttt tttgagatgg agttttgctt 134100
ttgttgccca ggctggagtg cagtggtgtg atctcggctc actgcaacct ctgcctcctg 134160
ggttcaagcg attctcctgc ctcagcctcc caagtagctg ggattacagg cgcacaccac 134220
cacgtccagc tagttttttg tatttttagt agagacaggg tttcatcatg ttggccagga 134280
tggtctcgaa ctcctgacct caggggatcc acccacttca gcctcccaaa gtgcagggat 134340
tacaggcatg agccaccttg cctggccgaa atatatatat ttttaaaaag gttattttca 134400
tcccagcact ttgaaaggcc aaggtgggca gatcacaaag tcaggagtta gagaccagcc 134460
ttgcaaacat ggtgaaaccc catctctact aaaaaataca aaaacaatta gctgggctgg 134520
tggcgagtgc ctgtaatccc agctacgcgg gaggctgagg caggagaatt gcttgaacct 134580
gggaggcgaa ggttgcagtg agccgagatt gcaccactat gctccagcct gggtgacaga 134640
gcatgactct gcctcagggg gaggcgggga gaaggttact ttcaacccca tgaaaaagtg 134700
agcaaaggac atgaacagac acttttcaaa agaagacata tggccaataa gaatatgaaa 134760
agcagctcaa tatcgctggt cattagagca acgcaaatca aaagcacaat gagatactat 134820
ctcataccag tcagaatggc tgttgttaaa aagtcaaaaa ataaccagtt ggatgctgat 134880
gaggttgcgg agaaagggaa cacttataca ctgttggtga gtgtacaaat tagttcagcc 134940
attgtggaag gcagtgtggc aattctgcaa agagctaaaa gcagaactac cattcgaccc 135000
agcaatccca ttactgggta tctacccaga ggaatataaa tcattctacc ataaatttag 135060
acacatgcac gcaaatgttc attgcagcac tattcacagt agcaaagaca cagaatcaac 135120
ctaaatgccc atcaatgaca gattggacaa aaaaaatgtg gtacatatta ccatggaata 135180
ctatgcagcc ataaaaaagg aatgagatca tgtcttttgc aggagtatgg aaggagctgg 135240
aggccattat ccttagcaaa ctatcacagg aacaaaaaac taaatactgc atgttctcac 135300
ttacaagtgg gagctaaatg atgagaactc atggacacaa agaagggaac agcagacact 135360
gggtcctact tgagggtaga gggtggagga ggaagaggag cagaaaaaac aattattggg 135420
tactaggctt agtatctggg tgacgaaacc atctgtacaa caaaccccca tggcatgagt 135480
ttatctattt aataaacctg cacatgtacc cctgaaccta aaataaaagc ttaagaaata 135540
ggttatttta aagactatcc taatgcattt gtttgtgtgt gaaatatggt tttgctaatt 135600
agtattcttt attgccagta aaagtaactc actagaggga gcttctaaga aacggggatt 135660
ttgatgaggg cacgtggata tcccatggat tttagggacg ggcacggctg ggccttgggg 135720
aaacaaaaca aaacaaacaa ataaaccaaa aatcaaaacc aaaaattcac attgaatttg 135780
gagtttgggt catattgtat gaacaggact gcttccacct gcattaatag gcaaattcca 135840
gaatactggg tgctgaatga acagtccagt atggatctgt acggaggctg taccaaggat 135900
tggtgtctgt ttatttttat ttgtgctgct attgaagatt ttctaatcat tagtgctaat 135960
attgcaggag aaaataatta atgaaggtgt ctactgttct attgtagtaa tttctgtttg 136020
cagggctcat taacatcttt gatcagaatg agcagctctt ttctggttgg aatagatgaa 136080
aattatacaa tgtatggagc cattcttcac cttgtccttg tttcttcttc atgttgcttc 136140
gacttattgc tcacaagttg acctccccct tagagctggg gtggtccagc agggctgcgt 136200
tgtgatgtgt attccttttg tgataggaga cttgctgaga gaggatcctg tttttttgtt 136260
tgtttgtttg ctttgagatg gagtcttgct ctgccaccca ggctggagtg cagtggcatg 136320
atctcagctc actgcagcct ctgcctccca ggttcaagcg attctcctgc ctcagcctcc 136380
cgagtagcta gtatgacagg cgtgagccac cacacccggc taatgtttgt atttttagta 136440
gagatgggat ttcaccatgt tggccaggca ggtctcaaac tcctgacctc gtgacccgcc 136500
cacctcggcc tcccaaagtg ctgggattac aagtgtgagc caccgcgcct ggccgaggac 136560
cctgtcttta atgggatgtt gggtgatatg tatgaaatgg ttcaagaagc agatgggaag 136620
tgtttgggag gcctactgcc agtggctcag tgtagccagg gaaaaacaga cacacctctg 136680
tgccatctct cacatcttag aaggtaacat tgagtttgct gcatagaacc atacagttct 136740
aggtcacctg aaactcagag ctcatgtgat ctaaacttct atatttaaag gaggaaagag 136800
actcagagaa gtaaaaatgg cttgaccaag aagtcagact ggaaccagaa gtggacatat 136860
ggactcctca ttcctgttcc agtaccgttg ctgccagttc acattgtctt tctaaaatag 136920
ccatttatag ggccacagct ccatctcaaa caagggctta gtatctgtca gtttgcgagg 136980
tctaccataa caaagtaacc cagactgagt ggcttaaaca gcacaaactt attttcttat 137040
gattctagag acagtaagtt tgaaatgaaa gtgtcaggaa agttggttcc ttctgaagtc 137100
cttctccttg gcttgcagat ggccatcttc cccctgtgtc ctctcgtggg cttccctcca 137160
agtctgtgtc ccagtctcct gttacaagga caccagtcat agtggaatag ggccctttca 137220
tatgacctta ttttgtttta attacctctc aaaaggtcca atttccaaat acagttatat 137280
tctgagaaac tggaagttag ggcttcaaca catgaatttt gagtggttgt ggggggaaaa 137340
aattcagcca gtaacagtat ccataagtta acttgattca ttagttgatt aagtatgatt 137400
aaaccagctg ggcgcagtgg ctcatgcctg taatctcagt actttgggag gccgaggtgg 137460
gtgggcacat catctgaggt caggagttcg tgaacagcct ggccaacatg gtgaaacccc 137520
gtctctacta aaaaaacaaa aattagctgg gcatggtggt gcgtgcctgt aatcccagct 137580
gcttgggagg ctgaggcagg agaatcactt gaacctggga ggcagagagg ttgcagtgag 137640
ctaagatcac atgcaccact gcactccagc ctgggcaaca gaggaagacc ctgactcaaa 137700
aacaagaaat aaagtaaata aataaatatt attaaactag attatattgg ttaccaagtc 137760
tttacatgac cattttaata gccttttcag atgttaactt tgcaataata tgcagccagc 137820
taattgaaaa ttctagtgcc ataaatgttt ttaattgctt actatgtgtc aggcgttgta 137880
ctaggcactg gggaaaactg taaataaaag agacccagtt ccttcctttt tttcaggttg 137940
cagtctatca ggaaaggcag acatttaaaa agggtcttgt gaggactgtt atgaaacagg 138000
aagtacgagt gccatttcta taccttagta caatcactcg ttttaattca catcttccat 138060
ggtggcaagt ttgcctcagt gtcagccggt caattgccac tcaaggggat cagaacattt 138120
atgtatctgg aatgcttggt acctagagtt ctgaagatca ctattctcat tccaaatatg 138180
ttttttcatt gccagaatgc tcactcagtg actggattag ttatgtgtac tctgcatttt 138240
tcgaagaggg gaaagctgct atttttatca tctagtagca ttctgatgac tccttgataa 138300
catggttact atacggaacc ccatctgttt ctctgctggg accacatctt agtcatattt 138360
ttgtccctaa tgtctggcat cgtgcctggc atttagtagg tcttcagtaa atatttgctg 138420
aataaatgta tgctgattga aaaattgcct gctattatca gctctctgtg catgataaat 138480
gccttgcctc tccaaagcga ttgtaagctt ctgagcagga acaccatggt cacacatggt 138540
ctgtctaact cagcgccttg taaataatag gaatgccatc cctaaatccc tagccccctc 138600
caggatggcc tgtcttcctt gcatctggga ctgttgaaga ttcttaatga tggaaaaatc 138660
atatacaggt tattgcatag acatacatta aaaaatgtag ttcgttcagt gtatccctag 138720
tgggcctatg gccataaatt aacttgctcc cagggtaggt agtactctct tcttcacttc 138780
tgctgtaatc acagctgcct tcattataga atcatagaga agtgaattaa ggtgaacttt 138840
gaaagaagga agagatgcag ctcacttgat cgatgtggga gtgggagtgg gaagattttt 138900
ctaggcataa ggatggcatc aaagaggctt ggctgttttt ccattcccag taatcgttga 138960
cagtttttta tttaacattt aaaaaagtgt cctccgaacc ttaggctgtt caaaaacaag 139020
tatttcatgg tagagattac gtcaaatgat aagcgatgca ttctgcgatc agtggcagaa 139080
acaaaggttg aagctgcagt ttgatgagaa tttaaacata cagaagtcaa aaaattcagg 139140
agttgaagtt aaactgcaag tgtgactcag tcccctcggg catatggtag tagcattttc 139200
tgaattgtgg catattcagt taaatttaag cccttgtttt tgcagagtcg ttgtgtcaag 139260
gttgcaatgt gagcagtaac tttagacttt cacaattttt tatattctca cccacagtat 139320
gtgctgttat agcatttgtg cactgaaatt tggtatagct tataaaaata aaaaaatggt 139380
gcaatgctca atctatggtg cagaatgtat atgattatga aggaataacc cttctgtttg 139440
cttgaacccg acctaatact gaaacaaaac accgccactt ttgcttttaa gtaaataaat 139500
aaaccataca ttgtggcaaa aggcatacac tataaaattg accgtcttca ccatcaagtg 139560
tacattcagt ggtattaact gaattcacat tgttgtacaa ctgtcaccac catccatctc 139620
cagaactctt tttttttttt ttttttcttg agacaaagtc tcgctctcat cccccaggct 139680
ggagtgtgat ggtgtgatct cagttcactg caacctctgc ttcctgggtt caagtgatcc 139740
tcctgcccca gcctcccaag tagctgggat tacaggaacc tgccacgacg cctggctaat 139800
ttctgtattt ttagtagaga cagggtttca ccatgttggc caggttggtc tcaaactcct 139860
gacctcaggt gatctgccca cctcggcctc ccaaagtgct gggattacag gtgcgagcca 139920
ccacgcccaa cccagaactc tttttatttt gcaaaattga aattctaccc attaaatagc 139980
aactcttctt ttcccttctc ccccaagccc ttggcaactg cttttccatt tctatgacaa 140040
tgtctactct agatacctca tagagggtga atcatacagt atttgtcctt ttatgactgg 140100
cttatttcac ttagctgcta tattattaat accagctttc tggggatata attcacaaac 140160
tgcagaattg aatggttttt agtctattca catcggatat gtttttgaag agacagtaaa 140220
accaatcctt ttttccttag ttctcagaca cacacatgct tcttatctgg caagtcccgt 140280
tataaaaatg ccatgaacta aatgggaaca gaagattggg ggaaatatct agattattct 140340
tagtttggtt cagattaatt gagatagcca gaatattttt gtaagcatgt ttgctttaat 140400
ttaaatgtct tcattttgct tcctggagcc agcaatatgt gattacttat tgttgttctt 140460
atggggtatt gtttgcttgc gtagttgatt gtgatgagtt ggctagaaat ttaacagaat 140520
ggaaatttct tcaagtctgg atttgttcaa agaacagttt gaaattgacc aaagcgatag 140580
atggaactga cacttgactt atttgagatc tggagttccc agtaatgaat attttggtcc 140640
aagtttgaaa aatggcattt catgtttatg tactgctgat aggaatattc attggtacaa 140700
ccatttagaa agacagttag gtattatcca gttaacaaaa acaaatgtgt ataccctgtg 140760
actcagcaat tttccttcta ggtgtttcct agagacttct gtactgtata ccacgagaca 140820
tggaggctct ccagcacagc tttatttgtg ttaataatgg tttaaaaaaa taaacccaaa 140880
ctacttgaat gtttattaaa gtgaaataaa caaattatga tatgatcaaa tgacagaaca 140940
caatacaaca atgaaagtga atgatctaaa actatatagg agcaatatag atacatttca 141000
gtaacctgat atgaagccaa aaaagttacg ttgcagaaaa attcaaaata tgaatgatta 141060
tttttgtaaa atttcaaaag tatgcatcat taaacaagta aagtggaatt tcaccctgag 141120
acagttaaaa aaaaaaggct agaagcttag aaagacatgg attagaactc gtttttctct 141180
gttctgagag tacatgtgga aatgaaagct accagctatt tctgccattt taaatgctca 141240
tatgaaattt ctaagtaccc tgcatagtaa gtctttaaaa tatcacatac acactactgg 141300
caggctaaaa accaacagaa agatggctgg gtaaaaagaa atcatgcatg cagaacactc 141360
ttacttttaa aaatttacat tcctgaaata gaatttttgg agagaagctt ttcttgaatg 141420
atgttagatt gaaggatata actaaaaata gaactgcagt ctttaataaa tgaaaattag 141480
tcaagattct aattagtact tcctgtgttc gatactaatt ttgtcagttc atttctttac 141540
ttaatgtggg ctgtacctat tcgcacatcc cttgtactct ttgcttgttt ggttatcgtt 141600
atgagaccac caccaaccac caccaccacc accatggtca tcatcatcat caccatctcc 141660
tagagcacat ggttttatga gccctgagct aagctcctta ccgtttaatg caaacatgtt 141720
cctccctcag ggtctttgca ttactctaaa ataacaccct catcagtttt tatccccttc 141780
accggtttaa tttttcctta ttgcacttac acatacttgt ttgtctttct catttcacta 141840
aaatttgaga gtgatgttaa gtctgtggaa gcagagccca tgcttacatc tgtcacttgt 141900
gtatttccag tgtttaaaac tgggcctgtc acacctagaa gctcactgat cataatcagt 141960
gatcatcaag tgaatgaatg cctgaattag cccaacaact ctttgaggta gttattgctg 142020
ttactattct acagattttt aaaaatggtg gcactcagat agattaaact actcgcccac 142080
atttacccag cttgtgggtg gtggaggcta gaattcaaag ccagtgtgcc tgacaccaaa 142140
gcctgttgtc ttaactactc cacttttctg cctatcatct gctgctagtt ctcagtgact 142200
ttttatttat ttatttttgc atagagcatc ttttcttctt ttcgggctat caactcatca 142260
tttgtttaat tctttgtttt ttgtttttga gatggaatct cgctctgtct cccaggctgg 142320
agtgcagtgg cacgatcttg gctcactgca acctccattg cctcccgggt tcaagcctca 142380
gcctccctag tagctgggat tacaggtgtg caccaccaca cccagctaat ttttgtattt 142440
ttagtagaga cggcattctc catgttggcc agggtggtct tgaactcctg acctcaggtg 142500
atccacctgc cttggcctcc caaagtgttg ggattacagg catgagccgc cgggcctggc 142560
cttgtttaat tctctgtatg cacctttttg ataaatagtt gtgtctcctt ttagggctat 142620
ttctgttttg catatacaaa gactttactc atatttcagg ttcagccaat ttcagcctct 142680
tgcagctaac gcccttgccg tgtttagtgc tattgtctgg gctctgagac tgaagcaggt 142740
ctgtgagagc agccgacaag gtgtcaagaa ggaaggatgc aataacccac tgagctgcgt 142800
tatctcctaa atgcatgtgt ctttatgcca ttgctaatgg catctaatga ccttgggctc 142860
cgaacaggtg ctgccttgta atctgcgctc atttgtctct ttctacactg ctagatttac 142920
tgaaataaca tgaacaggga aagcaaatgc tttcatggat gccaggaatg ctttatttat 142980
cttttaattt tctttcattt gtttcgggat gtagaagccc actttggagt tgaaataaaa 143040
caactaatgt tcagagctga ggttgtcacc ctttttagta ggacctcaga tctagaaagg 143100
gccccagaga gttctccttt gcttatagag gagagtgtag tcctgtggga ccacatgtgg 143160
tgctggccag cggagtaggt gggggtccta gaacttatgc agcctgactc cctttctggg 143220
gctccttctg aaacccagtg gcatcctcct tggcactttg cacacccagc tgtaaataca 143280
cctgtgccat ggagggctaa agccttttgg gggggcatat atgggccaac tgatgatcaa 143340
caacctctgt tttcttagat catctagctt ctttatataa cgtacctctt cgacttgggt 143400
tgaccaaact cagatgatct ccttaaagat gcatattaaa gattgcccca atttcttagg 143460
atcctaggat atgagaatct tcatctctct ctctctgtct gtgtgtgtat gtgtgtgtga 143520
gagagagaga gacagagaaa tttgtcctaa ggaaacaacc agagatgttg aaaaaagata 143580
tatatgttca agaagtccag cacagcatca ctaaacgata gcacaatatc tggagaattg 143640
aatgctagat aaatagatta tggttggaaa ttatagttat gttaaatatt cacatattct 143700
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt gagagacaga gagagagaga 143760
gagaatatgt atgtgaatat ttaacatttt gtgtttacag cctttgaaga ctactgcttt 143820
tcctctagca tagaaataag atcaaggttt ctcctactgt aaaagtttgg ttgagggggg 143880
ttattgtttt aaaatcaaaa taatactaat atataatgag ctcttattat ggtccagatg 143940
ctgtactaag tgctttacat acatgtaaaa ttcaattgcc acagcagccc aacagcatag 144000
tgttattagc cccatttgac agaacaggaa gttgaggctc agagaggata agcaacttgc 144060
ccaaggtggc agatcttaaa gtgatagagc tatgtttttt ttttttcttt ttttttttcc 144120
cttagagacg gagtctcatt atgttgctca ggctggcctc caactcctgg gctcaagcga 144180
tccttgcccc tcagcctcct gtgtagctgg gactatagtg catgttgcca cgcatggcta 144240
tagagctatg atttgaatcc aagcagtctg actccagggc atgccccaga aattgtttat 144300
tgtttccctg atcacagaag ggatgtatat attcatttag aaaaactgga aatacagaaa 144360
agaatgcaga gcagatcacg catacgataa atatgaacat ttttagtgtc tctagtcata 144420
tagatttttt aactgggatc atgctgattt actgtttgtg agctagctgc ctgatattta 144480
ccaggggtct gtatattgta aacatgctgc tgtgtgattt tcaagcccac acagtgtgat 144540
cttagggcct atcgtaagtt ttacatcact catagatact gtaatttcca tccataatct 144600
atttatctag catttaattt tccagatatt gtgctatcgt ttagtgatgc tgtgctggac 144660
ttcttgaaca tatatatctt ttttcaacat ctctggttgt ttccttagga taaatttcca 144720
gaactagagc tggtggctca aatagtaagg ccctttataa ggcttttgat atgtgttatt 144780
aaattactct tcttgagcac ttgccaacca tgacaaagaa cgttcatgtg tctgcactct 144840
ggacaacact aagtactgta attaaaaaaa aaagaaacaa acaaaaactc tgccaatttg 144900
ataagttaaa aattatatct tgttttaatt tgcttttttt agtgtagttt caagtgaggg 144960
tggatatttt ccttatgttt ctctgttttt tacatttctt ttttaaattg gccattcgtg 145020
ttcattgctt atttttgtct tagaaagttt ttccttttac tcacaattac atgtatttat 145080
tttgtattaa ggatattaac tctttgttta atggtattgg aaatattttt cccactttga 145140
tattttcctt tgaattttac ttacgttgat ttttatttac aaaatcaaaa tatctgtgta 145200
gtcaagcata ttaataattt tcaaaaagtg ttttgctttt tttttttccc acagttgaat 145260
cctttttttt tttttttttg agacggagtc tcgctctgcc acccaggctg cagtgcagtg 145320
gcacgatctt ggctcactgc aacctccgcc tcccgggttc aagcgattct cctgcttcag 145380
cctccagact acaggtgtgt accaccacgt ccagctaatt tcttgtattt ttagtagaga 145440
tggggtttcg ccatgttggc caggctggtc acgaactcgt gacctcaggt gatccatctg 145500
cctcggcctc ccaaagtgct gggattacag gcatgagcca ccacaccctg cctgaattct 145560
tttgttttgt ttgttttact ttaagttctg ggatacacgt gcagaacttg caggtttgtt 145620
acataggtat acatgtgcca tagtggtttg ctgtacctat caacctgtca tctaggtttt 145680
aagccctgca tgcattcggt atttgtctta acactcttcc tccccttgtc cctccctccg 145740
acaggccccg gtgtgtgatg ttcccctctc tgtgtccatg tgttctcaat gttaaactcc 145800
cacttatgag tgagaacatg cggtgtttgg ttttctgttc ctgggttagt ttgctgagaa 145860
tgatggtttc cagcttcatc catgtccctg taaaggacat gatctcattc ttttttatgg 145920
ctgcaatttt tttttaattt ttttttttgc ttttatacct agaaaagcct tccattcact 145980
agggtcagat aactatttac ccacaattta ttgtagttct ttattatctc atagtttata 146040
tttatcgttt attttgatgt gcgatcttag acatgaggat tcaatgaact tttgtcaaat 146100
attagatcag ttgttctcac attatgtatt tattagtctt ttgccccact gagaggagac 146160
atcatcttta ttaagtacta ataaaaacta aatgttttta gaaacatgag tatatttctt 146220
tttttttttt ttttgagaca gagtttctct ctattgccca ggcaggagtg cagcggcgtg 146280
atctcggctc actgcaagct ccgcctcacg ggttcaggcc attctcctgc ctcagcctcc 146340
cgagtagctg ggactgcagg cgcccgccac cacgcccggc taatttttgt gtgtgttttt 146400
agtagagacg gggtttcact gtgttagcca ggatggtctc gatctcctga cctcgtgatc 146460
cgcatttcta agccttatat tctgttatct tgatatttgt tttttttcta ttttgctttt 146520
gattctatga gtttagaaga ttttaatata attagattct ttcatatatt ttttttcagc 146580
atttattagc tatttttagt ctatttattc tttcatgtgt acatagacta atttagtcag 146640
attttaaaac atcttttcaa aataaaattt aatttaatag attagatatc aattcagaga 146700
gaatggaagt ctttactgaa ctcttgtaat ttttgatcca tgcacaatgt ttttccttta 146760
gttttttagt aatgcatttt ctgtttttat agaatctgag cagttcttgt tttctttaga 146820
gattttacag tgttggttat aattgtgcac ttaatcttta ttttccttat acagtagtcc 146880
ccccgatcaa ctgggggcat gttccatacc cctggtggat tcctgaaact gccagttagt 146940
accaaaccct atatagattg tgttttttcc tgtacgtaca caccatgata aaattcaatg 147000
tataaattag agattaacaa caataactaa taatcaaata aaatacttat ataaaaatat 147060
actataataa aagttatgtg gatgtgatct ctctcagtct ccaaatatct tcttgtactg 147120
tactcgccta ttttcagaca gcaaattgac caataaataa aaccatggaa agcaaaaccg 147180
tggctatggg gagactactg tataagggaa attttcacct gattatcatt gcgttttagg 147240
aaaactatta gtatgtctat gtaagtgtgt gtggaggggt atatgtatat cttctagtaa 147300
ctgaccatta tatataatta ttaatatata atatatataa ttttatatta tacattatat 147360
aatatatttt atataaatat ataaaatatt ttatatatag tatataatat attataaaat 147420
atattatata ctatatataa aatatattat atatattttt tgagacacag tctccttctg 147480
tcacccaggc tggagtgcag tggcatgatc tcagctccct gcagcctctg cctcccaggt 147540
tcaagtgatt cttctgtctc agcctcccaa gtatctggga ttacaggtgt gtaccaccac 147600
acctggctaa tttttgtatt tttagtagag acagggtttc accatgttag ccaggctggt 147660
ctcaaacccc tgacctcagg tgagccaccc accttggcct cccaaaatgc tgggattaca 147720
gatatgagcc actgtgcctg gtcaactgac cataatattg atctcagttc tagagtcttt 147780
cagctaattc ccttagatat tctaagtaga caataacatt tccaataatg ataattttgt 147840
ctcctgtatt ttaatatttt taacttttat ttcttctaca gcatcctgat ggtatgccaa 147900
ataataatgg aagagcagat acaaatacac ttgactttat tcctgaattt aatttttttt 147960
tttcttgaga cagagtcttg ctctgtcacc caggctggag tgcagtggcg cacgatcttg 148020
gctcattgca acctctgcct cccaggctca agtgattctc cggccacaga ctcccaaata 148080
tctgggatta caggcatgca acaccatgcc tggctaattt ttgtattttt agtagagacg 148140
gagtttcacc atgttcacca ggctggtctc aaactcctga cctcaagtga tccacccgct 148200
cagcctccca aagtgctggg gttacaggca tgagccaccg catgcagcct gaatttaatc 148260
attgactctt gtttttaact tttaatataa tattggctac tggtttgtgg taggtatctt 148320
ttactgtggc aaatacatag tattctattc taattttcaa ccctctttcc cacagaatat 148380
ttaagagaaa acctttttgg ccgctttgat aatgataatt tttgtctatt gaatggtgat 148440
gctgtgattt tcaggatgta tgtatcatgg aaactggtag agaaagaaag aactgagatc 148500
atgctgaagt atactggggc ccaccaagag gtagagctga gtgcaccaat tgtcaccaaa 148560
atggcaaccc gtaaaagaga accattctta agaaagagtc atgtaccatc aagcggggat 148620
ttccagaagc ctctgatagt aacagttctc ccttccattc ctttcctctc tactttcaag 148680
atgcgatgat gacaaaaaga ctgacttgtc aaaaaaacca tgaaattcca tacaaatggg 148740
caagctgaca tatagcagct tcggaaattt ccacaatcgc tcctctgagt tgcctcaagg 148800
agaagaaaag tgagagaaag gaagggtacc tttgccccca ttaaggcaca tgtagcatcc 148860
tggaagcttt gaaattacct gtccccaaag ttattagaat tatgtcattt tttggttgtt 148920
atattatgaa agcctcccca cccctaaaag tttgtctata ataatttttt tgatcaggat 148980
ttttacttct taaattaata ttaaagcatt ttaatgtttc tagaaaattt gtcatttgta 149040
tttatattat tttattttat ttcattttat tttatcaaga cagggtcttg ctctgttgcc 149100
caggctggag tgcagtggca cacgatcttg gctcattgca acctctgcct cccaggctca 149160
agtgattctc cggcctcaga ctcccaagta tctgggatta caggcatgca acaccacgcc 149220
tggctaattt ttgtattttt agtagagacg gagtttcacc atgttcgcca ggctggtctc 149280
aaactcctga cctcaagtga tccacccgct tcagcctccc aaagtgctgg ggttacaggc 149340
atgagccacc gcatgtggcc tgaatttaat cattgactct tgtttttaac ttttaatata 149400
atattggcta ctggtttgtg gtagatatct tttactgtgg caaatacata gtattctatt 149460
ctaattttca accctctttc ccacagaata tttaagagaa aacctttttg gccgctttga 149520
taatgataat ttttgtctat tgaatggtga tgctgtgatt ttcaggatgt atgtatcatg 149580
gaaactggta gagaaagaaa gaactgagat catgctgaag tacactgggg cccaccaaga 149640
ggtagagctg agtgcaccaa ttgtcaccaa aatggcaacc cataaaagag aaccattctt 149700
aagaaagagt catgtaccat caagcgggga tttccagaag cctctgatag taacagttct 149760
cccttccatt cccttcctct ctactctcaa gatgcgatga tgacaaaaag actgacttgt 149820
caaaaaaacc atgaaattcc atacaaatgg gcaagctgac atatagcagc ttcggaaatt 149880
tccacaatcg ctcctctgag ttgcctcaag gagaagaaaa gtgagagaaa ggaagggtac 149940
ctttgccccc attaaggcac atgtagcatc ctggaagctt tgaaattacc tgtccccaaa 150000
gttattagaa ttatgtcatt ttttggttgt tatattatga aagcctcccc acccctaaaa 150060
gtttgtctat aataattttt ttgatcagga tttttacttc ttaaattaat attaaagcat 150120
tttaatgttt ctagaaaatt tgtcatttct atttatatta ttttatttta tcaagacagg 150180
gtcttgctct gttgcccagg ctggagtgca gtggtgcagt catagctcac tgcaaccttg 150240
aacccctggg ctcaagcaat cctcccgcct cagcctccca agtagctggg actgcaggtg 150300
catgccacta tgcctggctc tttttctttt ttaacttttt tgtagagatg gggtctcact 150360
atattgctca ggctggtctc aaactcctgc cttgagcaat cctgcctcag cctcccaaag 150420
catggggatt acaggtgtga gccaccggac ctgaccattt ctatattcaa aattttgtta 150480
acacagtcaa atattacata ttttaaaaat ttaaaacatt ctcaatattt gtgaatttat 150540
tccacttctt atttttaatt tggtttgttc tctgaaactt aagattagct agcagtaagt 150600
caatcttatt tttgtatata ttttaaaaca ttttgtatat attttaaaat atatgcaaaa 150660
ataagataga cttactgcta gctaattaat agccttttaa aataattttt tttttttttt 150720
tttttttttg agacggagtc tcgctctgtc gcccaggccg gactgcggac tgcagtggca 150780
caatctcggc tcactgcaag ctccgcttcc cgggttcacg ccattctcct gcctcagcct 150840
cccgagtggc tgggactaca ggcgcccgcc accgcgcccg gctaattttt tgtattttta 150900
gtagagacgg ggtttcacct tgttagccag gatggtctcg atctcctgac ctcatgatcc 150960
acccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggccaaa 151020
ataattttta tctcacattt ggatagtttt atgtgctttt cctttatatt gcttttctta 151080
ggtttatttc cctttctttt tttttttttt taagacagag tctctctctg tcaccaggct 151140
ggagtgcagt ggtgcactct cggctcactg caacctccac cttacgggtt caagtgattc 151200
tcctgcctca gcctcccaag tagctgggac tacaggtgcg tgccaccatg cccagctaat 151260
ttttgtattt ttagtacaga tggagttttg ccatgttggc caggatggtc tcaatctctt 151320
gacctcgtga tctgcctgcc cgacctccca aagtgctggg attacaaagg tgtgagccac 151380
cgtgtcccac ccccttttct aatttattga gttgatcttt tatttttaat ttttcttaat 151440
gataaaaata ctaaagatat ttgcctctga ctgtaagctg cctacacttt gatacataat 151500
tttctcatta tctttattgt ctcagtctgt gattccataa tttattatct tttatactct 151560
acacctattt agaagaattc tttttgaatg tacaagttaa tttgaattgt ttacacttct 151620
gtctattaat gagttttgtt gcattgtggt cacagaatat tgaaaggtag taaaatttat 151680
tttatgttcc aatacaggat tcatttttgt taatgttcca tgagcccctg tatagaagat 151740
gcatgctcta attaaatcta atcaggctta tcttgtcatc agatctgcca tatttatgat 151800
tttatcctac ttctctatat ctttattaaa ttttcatctg ctggccgggc gcggtggctc 151860
acacctgtaa tcccagcact ttgggaggct gaggcaggcg catcatgagg tcaggagatc 151920
gagaccgtcc tgactaacat ggtgaaaccc cgtctctact aaaaatacaa aaaattagcc 151980
gggtgtggtg gcgggcacct gtagtcccag ctactcgaaa ggctgaggca ggagaatggc 152040
atgaacccag gaggcggagc ttgcagtgag ccgagatgga gccactgcac tccagaatgg 152100
gcaacagagt gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa atttcatctg 152160
cttatttttc caaggactga atgcagtggg gtagacttta acattattgc atgtctctca 152220
atctctgttt tattttcttt atatatttcc atgctctact atcttgacac atacaatttt 152280
gacttaattc tttggaatgt atctcttgtc agtaaaaatt tcacccctgt tgaatgcttt 152340
agatatgtaa tactgatttt gtattaacag ttgtaaaact gtcacttcta aatgtgcagt 152400
ttcctggtat tcctttgccc caatcttctt gtaactttta tgggtttctt gcagatagtc 152460
taagggcatt cttaatttat gacaccatct gagattcttt tgcttttcaa aacgaattaa 152520
tacctgtctt caatgttgat acgcttattc taatttttgt catcttttta ttcttttggt 152580
tttatgattc cttgatattt ccctcatttt ccattttgtg tgatatgatt tactgtctgt 152640
aatactcata ccttatattt aatcttctag ttgtcttctt aaatttgact aaatatgacc 152700
tatatttctg tatgagcaaa gtgaggaagc tggctgacca tacctcctcc ctgtataaga 152760
taagattaac acattttatt ctcctttgga attctccttt tcttttttaa agttagatat 152820
agacatatag atgttttgat ccagtttatg attactttta aatattatgt aacttttctt 152880
aataaggatt atctatatct gtgttccttt ttataacgat attcagttgt ttgttatatg 152940
ctctccttat atgtgtatat atttttctct agagacaggg tcttgctctg tggtgcagcc 153000
tggagtgcac tggtgggatc ataactcgct gcagccttga cctcctggct ctaaaggatc 153060
ccccacctca gcctcctaag tagctgggac tacaggcaca cagccccacg cctggctaac 153120
tttatttttt tttttttttt ttatagatga cgtctcgatg tgttgtcccg ggtggtttta 153180
aactcttggc ctcaagcaat cctcccacct cggcctccca aagttctggg attacaggga 153240
tgagcccctg tgctgggcct gaatccatat tgtgaactgt tttaaagcac aactacccct 153300
tttctttatt gtttaaaatt aaatttttga ttgattaggg agcttcttca aatatattct 153360
atgaaataca ttgtgttttt gttgctcctt gggatccaag aatgcctttt ttatttttta 153420
actctcatac cttagtagga aagttggtta gtttggaatt tttgtatcag aaccctttgc 153480
cattagagct gtgtagttgt tttatttctt ctattgtcag aaatctgatt ttttttccac 153540
cttggtgacc tggttacctg tatttctttt cctcctcact gaatgcttat gagttgtttt 153600
gacctcaaaa gttgcaccag aaggtaaata aatagatgga agttttcttt aatttattaa 153660
tttatattaa tatttatatc agttttcatt tttttcttct tgtatagagt gagtttttgg 153720
ttggttggtt ggttggttgg ttggtttact ctgtatttct tcagtttaga aaaattttct 153780
ttcattattt ctttaataat tgcttctgtg gtatttactt tgactatgca tcaatcatgc 153840
tatctctatg ttggcttcct actttgtctc ctgtatccat tagcatctat ctgatttgtt 153900
tatacttttc atcttttttc cagtgccttt tgggagactt tttcaggttt gttcttcact 153960
tgctggtttg atgctccaaa ggctgttttt ccttttcatt gcatcgaatg tagttttaaa 154020
taatactttg gaaaatcagt cattgaaaaa aaatcctaat ttttttttgt aagttggtgt 154080
ttctttttgt tttcatttac ttgtcattca cgcctaagtc tgggtctcct ccccttcttt 154140
ttcctcctcc ttcttcaaag gtgcaaatca catcttgtct gaaacttgtt tctatttcca 154200
gtagtaaata ttttttgaaa tcgtcttctt cctttatttc ttggatgttt cttgttttgt 154260
taaccaagtc cttataagcc caatgttgcc agttttgggt ctgctcatca ttgaatgatg 154320
ggagggctag cccgccctgg aaattgttct caaataatct ctgtaccatt agggaaaggt 154380
tggactcctt tcctcggtct taagctgaag gctttgttct taaaaatgta ctagaccagg 154440
tgtgtttttc agcagctgca caaatttgta gggagctgga gccacagggc aatctctatt 154500
ggggttcttc cttgcatggt tgctgcttgg caatgggtga agccatcgtg caagagacag 154560
tggttctcat tctgaacttc tccctgaccc tagcttcact ccaagccccc tttgtagcag 154620
aggatgcatt tttctggcat cagagtcctg ctatgtagag agacatctca catcccacca 154680
gatggccatg ggcatggagg acttatgctt ggttctcttc ttagtgcctt ccgaatgtga 154740
atgccctgga caccagacac tatctggttt gctagcctgc tctcacctcc agcgttcagt 154800
ccattttagg aagatttcta accagtgctc tgtcagaatc tcttcttgtt tcttctcaca 154860
gtgctgtgcc accttttcaa gaaagagaat cccaacacac atttctgatt cagcctttta 154920
tgtgatgctt tctctggtct atctaacaaa atgtcttaat gttaaaaatg ctgggtgccc 154980
tccttttttt tcagcactgg tgtagacttc cccccatctt tatatttgtg ggaaatggat 155040
gttcagattg atgacgtgct ctaaagacag agaggggaaa tttacaaaac acaaatggag 155100
aggaatgtga attttacaaa agtatttatg gagttctcta aataatgaac tccctcagga 155160
cacttagcac accaagtaat gtaaaaagtt aggcttacac gtagattgtc agacacacag 155220
cttttgtata ttgtaagcta cacctgtatc cctgtaatgg tccccaggag tatcacgctg 155280
catggtccaa ttaggtacag aagaactctc aagtagcagc cagtcacttt gcctgtaata 155340
atgtttatga ttcagagtgg tgcccaattc accctttgca cttttcccag tggcatttgg 155400
cagctggggc ctggttattc agcagattat tgcttctccc cagaagcttt tgtgatcctt 155460
gcaggcgctc tcctactagg gagagaagaa tgccaacata ttttaaggaa acaaagaata 155520
atagtgtcac acgtctttga ataagagtga aaaaatagtt ctccccacat ccaaacacag 155580
tgtagtcaaa attaagaaga tagaaatcaa gtgtgcatgg gcagagggta ggtcataggc 155640
ttaatgaacc cagaagagct ttatttattg acttctattt tatcccttct cactggtcca 155700
gctgcaatga ttgtcaacaa aggtgactta gaaaaagaga gaccttggag agagacagaa 155760
agagagagag ctggataggc agacagatgt agagcaggtt tgtttgcttg gcagaacatc 155820
caagtcgcag atggttctag aacagaggta atattgccag ggttgcgtgg aacagatctg 155880
gactaaagct gaggcttgca ggtaaagcca gtggctccca ctccaatgtc attcagcaca 155940
tagcaatttc agctggagat ctgtttatag cataaaacag acactgcaga cttttttctc 156000
catgagactt taatgtttca tttactaaca agattatata tgggaagtgg atgtcataag 156060
aagactgtag aatcctattg tctcaccacc gattgagggg cctttgtcta tagaccaagc 156120
acgtcttttt cctcggatgc cttgggcatt tcagaccatg cccaaaaaga tatgttgtga 156180
cctgcagacc tgtggttgac catattagga tctgtgatca atttcttaga gattttgggc 156240
ataaaaaatg agcaaagagc catctttagg aatttgggga tatgcttgac ccaaggtatt 156300
tttgttttct actaacacat tttgatgtaa agcaagaagt ggttttcaac agttgaccat 156360
ggttgcctag agagatgggt acatattcat gtattttgac ctatcagatg gaaacaggct 156420
tcactcttag aacttccctt tggatttccc acccacccca gacactgaca ttccattttg 156480
aagttacaca tgaatataac actgacacat tgggacatgc tttccaagct caattaccat 156540
gcagcgcaat atcaattaag tggatcatga aacatgtgtc tgattgtctc acttgcataa 156600
tttacatttt ttgacaacac ttaattctcc cttatatgtc caggtttcct attttgtgat 156660
gcacataatt gcagaacttg ggagctagaa tggaccttgg agaggtccct tacgccaacc 156720
ctttcacttc acagatgtag aaactgaggc ttagagaggg tataactttc ccaaggccac 156780
aaaggactag tttacagcag agctgggctt atataacagg gctgcctggc cggacgcggt 156840
ggctcatgcc tgtaatccca acactttggg aggccaaggc gggtggatca cctgaggtca 156900
ggagttttaa actggtgaaa ccccatctct actaaaaata caaaacatta gctgggcatg 156960
ttggcgcatg cctgtaatcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 157020
cgggaggcag aggttgcagt gagccaagat cgcaccattg tactccagcc tgcgcaataa 157080
gagcaaaagt ccgtctcaaa aacaaacaaa caacacacac acacacacac acaactcatg 157140
gaactgtata ctttccccca aaattcaatt tagggccggg cgtgatggct catgcttgta 157200
atcccagcac ttcgggaggc tgaggcgggc ggatcacgag gtcaggagat caagaccgtc 157260
ctggctaaca cggcgaaacc ccatctctac taaaaataca aaaaattagc caggtttggt 157320
ggcaggcgcc tgtagtccca gctacttggg aggctgaggc aggagaatca cttgaaccca 157380
ggagtcggag gtcacagtga gccgagatcg caccaccgga ctccagcctg ggcgacagag 157440
caagactgtg tctcaaaaaa taaaaataaa aaaaaaaacc cacaaacaaa aaaaccacaa 157500
acaaacgaac aaacaaacaa aacagggctg cccattatcc cctgcatggc tccagagcta 157560
ttcttaagat cctctgcact ttggatctta agataacatt agatttcata gtatccatga 157620
aataacttag acctggtctt ggaaatacgt ttcaccatcc aggtacccat cacatgtgtt 157680
cgcaggtgag gctttcttag cagcactatg taaggagaca tagtaaagaa atatttattg 157740
aatactgaat attgattgag cctatgtcct gtgctaggtg ttctaaatat agaaccttat 157800
ctcatcccat aactctttga gttaattgtc attctttttg tttgtttgtt tttgagacag 157860
ggtctcgctc tgtctccaga gtgacacact gtactccagg ctggagtgca gtggcgtgat 157920
tgtacctcac agcagccttg aactcctggg ttcaagcgat ccccccacct catcctcctg 157980
agtatctgga ctatatgtac gtgccaccac acctggctaa ttttttaaac attatttgta 158040
aagttagggt ctcacatgtt tcccaggctg gtcttgaact cctgggctca agtgatcctc 158100
ccatctcagc ctcccaaagt gctgggatta taggcatgag acactacacc tggtcagtat 158160
cgttatcttg gccattttac ggttaaggga atatagaccc ggcaagtttc tatagcttgt 158220
tccagaccac atagctagta agctttgagg ctcatcctag ggtcactgct tgaataacct 158280
gcatttttct actgtaccat atgtattctc ctgctaatct tcttactgag agagatggta 158340
gttcttctaa gtatcatatg atccaaaagt tgcttaacca agagctccag catctgaatc 158400
cctgagcata cctcttcccc catgcatcat acctgtttcc cattctcttt gaataatttt 158460
gaattgtgag caaatgttct tacaaaataa agaagagagt gtgtccctgc agcattgtct 158520
aagtgcagag gatcttaaga atagctctgg agccttgcag ggctcatggg cagccctgtt 158580
atataagccc agctctgctg taaactagtc ctcttgtggc cttgggaaag tcataccctc 158640
tttaagcctc ggtgtctaca tctgtgaagt gaaagcgttg gcgtaaggga tctcctcaag 158700
gtccattcta gctcccaagt tctgcaatta cacgcatcac aaaataggga gcctgaacat 158760
ataaaggaga atttagtgtt gtcataaaat gtaacttata caagtgagtc aatcggatac 158820
gtagttcatg atccactaaa ttgatactgt gctgcatagt aattgggcat tagtggaagc 158880
agttcacgta aaagactata atttgtatta cttttacacc attgcaacac tttttattgt 158940
tcctcagtcc ttgatttgtt ttctaatgtc tctagtgtgt ttaacacttt ctcttgttat 159000
gatatgcacc atacatgtgc atgtaatata attcacatat ataacatgaa aacatctgat 159060
tcccacatct aacagtcaga cttccgtttt cctcttttcc aaaatccagg tggtcagctg 159120
ggtgcagtgg cttgagtgtg tatttccagc actttgtgaa gccaaagtgg gaggattgct 159180
tagggcagga gtttgagact agcctgggca acatagtgag gcctcatctc tacatttttt 159240
ttttttaatc agccaggcat ggtgatgtgt gcctgtggtc ccggctactc agaaggctga 159300
agtgggagga tcacctggtt ccaggaggct gaggctgcag tgagctctga ttgtaccact 159360
gcactctagc ctgggcaaca aagcaagcct gtctaaaaaa aaaaaaaaaa aagaagagaa 159420
acaaaatcca gttgtctgaa gaggaacaac ttcttcctga gacattttct ttatttcttt 159480
taattttgtt ttcttttttt tagatacagg gtctctctcc atcacccagg ctggagagca 159540
gtgatacaat tgtggttcat tgcagcctcg aactcctggg ctcaagcaat ggtcctacca 159600
cctcagtcag ttgagtagct ggaactatag atgtgcacca cgtgccacga taatttttgt 159660
tttttttttt ttttttgaga cagagttttg ctgtgttgcc caggctggtc ttgaattcct 159720
gggctcaagt ggtcttccct ccttggcctt ccaaagtgct gaggttacag gtgtgtgcca 159780
tgtgcctggc ctgttcctct ttatctcttt gtattgagag gttcttgaga agcatttcca 159840
tctgctttcc atcgttttct cccatgtgca gacttggtta aaagaccttg aggaatcccc 159900
cctttacgaa gccttatcca tgagaggaca agataaggag acccttggtt tgtggattca 159960
gcttccatgg tcattcccat cagttcccac cacttctagg agagatagta tcactcgatg 160020
ctgacctgga aaatcctggt agagacccag gaactcatag gactcggtcc ccacaccctc 160080
atgccagtac ctgtgtgacg gagaggcgcc cctttgcatg gggtgctgca caatgccttc 160140
gtcaatcttc tgccactgtc ctcatcccca ccccagcctg ctcacctctt cccctgtacc 160200
ccacagccac caggccagtt tcacctggtg gaacacttcc cccacttcac ctgctgtgcc 160260
tcacctactt cctcctgcct gttctggtga agcctcccgc gtcttttctt gtggtaatgc 160320
tcttttctgc ctctctaaac ttctgccagt gtttttgtat ttgatttttg aaattcaact 160380
cagacctcca aatgaggcct aagtcaagcc tagcttttgg cgagctcacc ccatttatgg 160440
tgggggcctg cctggtcacc tgctcgtctt aaaacctgcc tttccttatg gaactgtgtt 160500
ttcaatgagg ttctggccgc taagcactca aggctgtgta cactcaactg ttgggctgtt 160560
ggaggtctcc ccatgagaac tttattacag aatggagtat ggagcctgga aagggaaggt 160620
ggcccagtga ggaatggtac tgcattctca gtctctgggt gagttgaggc aggggaccag 160680
aaggagagga gggaggagtg ggaaaggctt aaagcctctt ggaaggagaa aagccagggg 160740
aaaggagaat ggtaactggg aaatgggcta acctcagacc tgcctttagc ggacgcctgg 160800
ctcgagggcc caagacctca agctctcaga aactggtaag aatcatgctg tcccaggtcc 160860
cagtgaggtg actctaggta ggaggccctt agcagaggtg gctgggtcaa tcccagtcgg 160920
ctgcttttat cttttatttt atcggcactt agaaagaaag tatggtgctc cttctgagag 160980
ggctctttaa cattgcaatg ggccaatcac tttatatcat tatctcataa ttattatatt 161040
acattacatt atattatgat aattcctgtt ttgtaaatga gtagccgaag ctcagttaca 161100
tagcctgtcc atggtcacag tggaacatga acccagtttg tgatgtcaaa gcatttctat 161160
ctttatggca agccttcata ggaagcaaaa gaagcttgca aaagtaggag acgttacctt 161220
atcctctttc cccgttcaga atttgggctg cggccaggct cagtggctca cgcctgtaat 161280
ctcagcactt tgggaggccg aagcgggtgg ttcatgaggt caagagatca agaccattct 161340
ggccaacacg gtgaaacccc atctgtacta aaaatacaaa aattagcagg gcatggtggc 161400
ctgcgcctgt agtcccagct acttgggagg ctgaggcaag agacttgctt gaacccagga 161460
ggcgaaggtt gcagtgagcc aagatcatgc cactgcactc cagcctgggt cacagagcga 161520
gactccatct aaaaaaaaaa aaaaagaatt ttggctgctc actgatgtta gaatttaaaa 161580
gaaagtaaag tgatgcttca attaaaaaaa ttaaaagctt aaaaaaatta aaagctttaa 161640
agtatggatt ttttttggtg ggcggagcaa aaacagtgac tgaagtgtat tcatattgaa 161700
acactgtggt gtttcactgg tgttcaagtt gacagggcag gggtgggaaa gaattacgga 161760
gtagaaaccc ctggggccca atggggaggc acctagaggg cctaagggga aggatcctac 161820
agatgaactt gaccttcttt atgattttgc ggaagacaac tctgcttatc tttcctctgg 161880
gaccagtaaa atagctgttg ggggcagatg ctttgctgat gcttagtata caaaagacag 161940
cttatatggg ggcaatatta attttcttaa gtcccttggc atggattctg aaaactttaa 162000
gatttatgat ttgagaaccc tgactctaaa atacgtgaga attttctgct tgcaaaatag 162060
attacgcttg cacaaaatac gcttgcacaa aatcttctac ttgtatttct actctggatt 162120
gttgaaacaa attgattttt tcttttttga gacaaagtct cactctgtca tccaggctgg 162180
aatgcagtgg tgcaatcttg gctcactgca agctccgcct cctgggttca cgccattttc 162240
ctgcctcagc ctcccgagta gctgggacta caggtgcccg ccaccacacc caactaatat 162300
tttttgtatt ttttagtaga gatggggttt caccgtgtta gccaggatgg tctcgatctc 162360
ctgacctcat ggtccgcccg cctcggcctc actaagtgct gggattacag gcgtgagcca 162420
ctgcgcacag ctgaaataaa tagattttaa gtggctggct ggctctcaga ttgcatcctg 162480
ttagaaagtc agaatagaaa atagatgcat tttagcagtg ttggaagaat aaactcaaag 162540
tcccctggaa atcctggacc ccacccacct cttaccaagt atccagcagg aaccttcttc 162600
cttactattg ttataataca ttctagcccc agtaatttgt tccacgtatc tcattagagt 162660
gaagatagca acatacttaa ataagaattt catttttcag ttttagcttt tgatgtaggc 162720
taaatgctct gtgtcacata acttagacta cctacatgcc tcatacactg ataccctatt 162780
ttgaaattac acatgaattt aacactgcca cgttgggacg tgctttctaa agttacctat 162840
gaaataactt agatccggtc ttggaaacac cttttaccag ctaggtaccc atcacatagc 162900
ttagtaggtg atggtggggt ccttcgtttt tttgactacc cgtataattt caggagcaag 162960
cctaattgtt atgcctcctt tgttattacc tcccctagcc tagataacat gccttccaaa 163020
ttgtattgag agtacacagg aagacaactg cagcaggcaa ccagctctaa caactgcgtc 163080
attttctaag aatcaaagga attacttgag tttctagttc tggctttggc ttgccagaca 163140
tataccttac cccagcgagg taaatgattc aatcatttgg gaatgattga agttgctgcc 163200
taattcataa cttataggtg attaaacttg taaagtattt tgaggctgtt tctttcattc 163260
atttattcca aacaaacatt tgttgttgaa tgggtagtga ctttgatttt aaaacactat 163320
acagacataa aatagtggca gcttgtagat agcaattttt taatttgctg tccttaagga 163380
atttcgttac caaatcctca cgaatcttga accttagaag aataatcctt tcctttgttg 163440
gagttttaaa tttagaataa tcagacaata gtgaagcatt ctgttcaaag cattcctttt 163500
aggctaccca tttattatac gctgctctta agaggagatg aatttgatta gcattgaaca 163560
ttcagtcagt gtttttgcat agctaatatc acggagaaat tttcaaaaaa agttatgcct 163620
gctatttaac attattatac agtcaacttt taattatctg tattaatgga atgtaatcag 163680
tgatgtgttg ctccaaaatc atttcctttg gctttgagaa gcaccggatg atgcttttat 163740
tggtttgtgg ttttgcttag atagtattaa aattgtgcca catgtgtgca catagctcat 163800
cttagggagg aagtagccca aaagtatact gggggctagg gaaaggtcaa ctggaatttt 163860
taaacctacc acagatacat atacaatgga tgaccccaag attattcatc ttaattatta 163920
aataaaaaac aatggccaag aattatataa tggcagctgt gtaagaaaaa agacgcaatg 163980
aaccacatgt gagatttcca tgtaggacac acattgtttc ccacctttcc cttttgaaat 164040
ttcctgaaag tgaaacactc tcataacact acagcagtga acactgttag atttagtgat 164100
cctccaaatg cattttgctg gtgctccaaa taggcctctt gggggaacag aaggaacaga 164160
agggctgatg tcttgacatg ttaatgtttc tagataatgt cacctttagg tgtgatagct 164220
gttactgttt attatttttt aaataaccct cttgttccca ttcattcaag ttaagctttt 164280
tttttttttt tgagacggag tttcactctg tcaccaggct ggagtgcagt ggcgcgatct 164340
ctgctcactg caacctctga ctccctggtt caagctgttc tcctgtctca ccctcctgag 164400
tagctgggat tacaggcacg tgccaccata cccagctaat ttttgtattt ttagtagaga 164460
caaggtttca gcatgttggc caggatggtt tcgatcttct gacctcatga tccgctcgcc 164520
tcagcctccc aaaatgctgg gattacaggt gtgagccacc atgcccggcc taagcttgtt 164580
ttttttttaa tgaataacaa tgatagaagg aaatctttgg agggtttatc ttcttagtag 164640
cggcctttca aatttcaaaa gtcttctcag tgcacaaatc tgtttttgca tgaggctgct 164700
atagggccag cacttttagt cctctgtggc ctgttcacct gagtgagtgg tgacatttct 164760
tggttcatac cttggaaggc aatgatggct ggccctttag agtgaggtga aggaagactg 164820
atccctgggt gtggaggtac tgatgcatag gaaaagaaaa catctttggt gacaccattg 164880
ggtgtcagat cagtttttgg caagttggca ggaaagtctc caaatcagtg gggtctggct 164940
gggcaccagc aagttggaag ctgcattagt tccttctgct ggcatgtccc cctgtcatct 165000
ggccatagcc tcatctgctc ctactacctt gcaggtgccc ttggggtaaa gctgtccaga 165060
tgcacatgaa cccctcctct tttcagctgg acaccaagcc aggaaaagga gaggtgtgac 165120
tttttgacgg aggccagttt ctatgtcagc agccttgcca gtgaacactg caaaatggtg 165180
tcagcctgca gcctttttgt gcactggagc agagctcccc tcaccacatt tgtgaaacag 165240
gttctgtcat ggggcccagg tgtccttttc tcctgccacc cccactccag cttgctggcc 165300
gccttatcat tccacaccag gaagccagca tccttgagtt gtccttactt cttatgacct 165360
gctgtgtaga aagagagggg aaaaccagtg tccgagtggc tgctgtgggt gtggtctggg 165420
ccgcgtagtt ttatatacgt aacaaccttc tgagacaagc gttagtgact ccttttacag 165480
cggatgaact tgagggtcaa gccagtaaat aatttcctca aagtgacaga gctggaaagt 165540
ggtaaagtta ggatcaatac tcggctttga ttttaaaata tgcatatgca tatattttgg 165600
agatctggat ataccacttc caaagtagca tattatactg aaatttcaaa agagaaaaca 165660
tctttaaaca aaaggaaata actcttaatt atggagtttc aggtatcaat gtgttgctgg 165720
agggctgtga tcttaaaagc atgtcacatt ggcaacccgt tccggcaggt tgtgacaagc 165780
tatgtagcat gcatgaaagc atcattcatt ttttaaaaaa tgtcttcacc atttatttct 165840
ttaatttttt gttttaactt tttatattta taggcaataa ttatgtatat ttatggggta 165900
cagtgtgatg tttttataat gcatacatta taacaagatt caatcaagct agttaatata 165960
ttcatcacct caccagttta tcattttgtg tgtgtgtaag aacattaaaa atctgtgtta 166020
gcaatttact tcattcttaa tggcagactc agcttctttt tttttttaaa tcctagactg 166080
ttggcttctc cttccagcag tgttgtagga ctcagctgcc tttctttgct gtccctggcc 166140
agagatgtgt gcactcctgg tctcctaata aaactttagc ctatgctggg agccatggat 166200
ttggcagcac tgcctttagc atttaggaat atgtttctcc ttacatcaag aatagtttta 166260
ggccaggcat ggtggctcac gcctgcaaat cccagcacct tgggaggccg aggcgggtgg 166320
atcacctgag gtcgggagtt tgagatcagc ctaaccaaca tggtgaaacc ccgtctcgac 166380
tgaaaataca aaaaaatagc caagtgtggt ggcatgtgcc tggaagccca gctactgggg 166440
aggcagaggc aggagaatcg ctagaatctg agaggtagag gctgcagtga gccaagattg 166500
cgccactgca ctccagcctg ggtgacagag caagactctg tctcaaaaaa aaaaaaaaaa 166560
tagatttatg ctgcttgttg aggaccagca gtattctcaa ccatgtgagg cattcttcga 166620
acatgtgaag cagcattttc ctggatgggc atttctgcca taattgtggg cagaaaaagg 166680
tgtggtccac atatgcccaa cagggccaag gggcaagggt gagcatgtac ctatgtctta 166740
taccccggag attcttgcgg ctgacgaggt tcccttacaa agcccaaagg aattctcctc 166800
cttccaccgg aggtgtttat aacctctaat ttgctcacca tgcttctagt ggaaggagta 166860
ggagctcaat cccctgggag gctgcggcag agccagagca ggctggtgac ccagagcagt 166920
ggcactcccc tctgagtgca tgatgcagat ggagcaggag ggggatgcag gtgggacacc 166980
ctgcgccctg caggtgagtg cacagccagc gagacaccca atcagggagc aggaaggctg 167040
tccctgtggc agcaggtaaa agagagagtc gctgagatga aattcgtggg tgtgtgcttc 167100
agcttgtttg aacagctcct gtgcaagatc ttatagtaaa tgctgagctt ctttgtgctc 167160
tgtgcctgtc ggtggaaggc atagcccttg atgaagattt ctccttctac ccatcttgcc 167220
tttggaaagg gctccccttt gacaaatgct gctgtagtat ttgatgcagc ctccatgagg 167280
tgctttgggt gggaagtgga ttctgacctc atttcccaga ggaatttgaa gtggagggga 167340
aggactaatt ggtccctcat taaggactta caatgaagta cagtatttct cctgaaagga 167400
taatctaagt cactggataa aatgcccaac acacttttaa cgtgacatag gaatccaaag 167460
tcatttttaa atcaaagatt tttgtagttg tggagaatgg ctgtgtttta atgggatctt 167520
tacatatcag cattacaaag ggctccttca aatgtgatga ttttaatgtt tttgctgggg 167580
tttcacctga ggttccaaat acatatttcc ctatcatatt tgcaggcatc cagcacccga 167640
ttttagatat gcaaatcagc tcactttgtt taccaggctt tggatagggg agaaaaggag 167700
gtctgaggct gggcacggtg gccacacctg ttatccagca ctttgggagg ccaagatgag 167760
aggattgctt gaggccagga gttcaagatc agctttggca agatagagac ctcgtcttta 167820
caaaaaataa gtaaaaatta gccaagcatg gaggcgtgca tctgtagtcc cagctcctct 167880
ggaggctgag gcaggaggat tgcttgagcc caggagttag aggctgcagt gagctatgat 167940
cgtgccattg cacagcctgg gtgacagagc tagattcagt ctctgaaaaa taaaaaaaca 168000
aaataacggg gctgcaaaag cttccttgac gaagaaggaa agtctctcgc tcctgtttaa 168060
cactgcctgg ctgggttcca gctcactagc ttaaaacgag aaggcaccac cactgtgatt 168120
aaaataaggc cctacttaat taaaacagtg tgagaattta ataagaggca taagacttca 168180
ctgatagtca ccaaaaaatc tcaaaaaggt gacttaacag gcattaatag catatgttgc 168240
ttgtttactc tctgtcaaca ttccgttttc cagagacatc cttcgtacag gtgaaagtct 168300
ctcattcctc cctctcccct cactgcctgc ctttcagcca tttccttgct ttttgtagtt 168360
aaccagtaag aaagagacca taatggagaa agaacacact gactgtgttt cacagactgt 168420
tgccctcatc tccacttgtg ttaaagaagg taaattagtt cccctccaga ttaacttcag 168480
cgtcagctgt ggtgctttcc tgacacttct taacatttga acagtaccac attctgtccg 168540
ttttatcgtt gtctcttctc ataccctgta tttgccaatt ctgtactcat gcccagacag 168600
atctataggt atatgtagga ggatgatgaa gaacgggccg attcgtagct caccctttga 168660
gccaggacca aaggtttggg agtcttaggc tctgacctta ttcttttgga gaggaaagaa 168720
tcattttcct ttaagcctaa gtctggcaaa atctaattac aaagtttttc gattttgcta 168780
ttttaaaata aaagctaagc cttcccccca tctaatcagc cctctcttcc tctgcttcta 168840
atagtgaagg aaataaagaa gtctctcaat ttcacaagct tgaggtactt atatttgtac 168900
atgatttcct gttctaagtg ggtggttttg gcccctggca cttcatgtac gctagggcat 168960
ttttggacac ttttggtatc caccttgctt aagaattgaa tgactaggaa agaaggtcat 169020
ggggagtctt caaattatta accctcagtc caatctaagt cattagttaa tgccatgttt 169080
gaaggtggta aagtaaccgt catcttacga agtaactctc gtttgttatg cttagtgctg 169140
aacaaagtat aaactcacca atgtgagaga cagggacagg atgcttattt ctttatggat 169200
atttagaatt tgagcctgta ggctgggcac ggtggctcac gcctgtaatc ccagcacttt 169260
gggaggccga ggcaggcgga tcacgaggtc aagagatcca gaccgtcctg gccaacatag 169320
tgaaacctcg tctcttctaa aaatacaaaa attaggtggg ggtggtggtg cgcacctgta 169380
gtcccagata ctcgggaggc tgaggcagga gaatcacttg aacccaggag gtggaggctg 169440
tagtgagccg agatcgtgcc actgcactcc agcctggcga cagaatgaga ctccgtctca 169500
aaaaataaat aaataaaaaa aaaaaaagga aaaaaaggaa tttgagcctg taacaccaac 169560
ttcagcacaa atagatctct ttcttgattc tgaaatgatt tatcagtttt aaaaaatggt 169620
ggggtgcact gctggtggga gtgtaggttg atatagtcat ttgggaaagc aatttggcac 169680
tattgtttaa cagtgaatat tcatagaccc attcctaggc aataacccag ggaaacttat 169740
gctgatgggt attgttccta atggacacag cattgtttct aatagaaaaa aaaacgaagc 169800
tgaaaaaatt ttaaaggtcg tcaacagaca tatatatata tattagtcta atatatgaca 169860
attagactaa tatatatatt aattagacta atatatatta gcttctatcc ctgtagacta 169920
atatatatta gtctaatata taataattga actaatatgt ataatttgac taatatgtat 169980
attagcttct atctctatag acatatatta gtctaatata taataattag actaatatgt 170040
ataataattg gactaatata tgtattagct tctatctctc cagactaata tatatatata 170100
ttagtctatt gagaaccttt atatatatat atatatatat atgcacacac acatatacac 170160
gtacatacat acatatatat aattttttgc ttcacagaat ggaatattat acagcagtga 170220
atatgaagga actatagtag ctacctgtaa caacatggct aaatcttaga aacaatattg 170280
tgtgaaaaaa actagtcaca aaagactata tacagtatga tagtattata aagtttaaaa 170340
tcaagcacaa ttaaactatg tattttagag agtgatagat agaaaattta agatagtggt 170400
tacccctgga gagaaggcag gaggatggct tagggaaata gcaaataggt agatggatca 170460
aaatacccct aaatgtctag ttctcaaata gggtggtcgg tgtatgcctg ttcattttat 170520
tcttatgctt cacaggttac gtacatgtta gtgcattctt ttgtgggtta caaacattgc 170580
atgatagaaa tatttttaaa gtgatagcat gtcagaatta tggcttgttt tttccatctc 170640
tatttcctaa cattctcttt ccatagtccc cagggagggg gcttgagatc acacaggagt 170700
aattagaagg tctgcttctg acagtgtcgc tccttgagtg gtggaggttt tagggggagg 170760
ctgacagtaa ctactgagtg gaattgagag gtgaagccag ctggacttcc tgggtcgagt 170820
ggggacttgg agaacttttc tgtcttccaa gggtattata aaatgcagca gtcagtgctc 170880
tgtagctagc aagaggtttg taaaatgcac caatcagtgc tctgtaaaaa tgcaccagtc 170940
agtgctctgt agctagcaag agatttgtaa aatgcaccaa tcagtacttt gtaaaatgga 171000
ccaatcagca gggttctaaa agtaaccaat catggggagg attgagaaaa gggcgttctg 171060
ataggacaga aacaggacat ggacgggaaa aataatggaa taaaagctgc cccccccaac 171120
cccccacccc cacccgcacc agccaccagt gcaacctgct cagattcttt tccagctgtg 171180
gaagctttgt tctttcactc tttatgataa atcttgctgc tgttcagtct tttgggtctg 171240
tgccatcttt aagagctgta acagtcaccg caaaggttag cggctccatt cttgaagtca 171300
gcgagaccac gaacccacca gaaggaacca actccagaca cagaatcagc taggagacgt 171360
gggtgctttc tgtatagtgc ttcctaccaa aagcctagaa aatcttgggg cgtggagaaa 171420
agaaaatcca tcaagtaaag gcttgatcac ctcttggaaa acccatattc attgtcccaa 171480
cagtgactaa tacgtctaac tgtgggcctg ggtaggatat tatgagaaac ctgttctttt 171540
ggtgcccacc tttcttttct gagcaacacg tggtcttctg agtgaggcag gagtccggca 171600
tatgcgtgat gatgtaatat gttaggcagc caggccctca ccttttcaaa ggttcgatct 171660
tgaaaaatca aaggtggata tgtgagaaat aagcccatat aggaataaga atgacaatgg 171720
aagtggaaaa tgtaagttgg gactgatgtt ctgctgcttt gagtactgaa attctctgct 171780
gctcggattc atcatcactg aagtgctggc cagtactggg aggggggcag agctctcccg 171840
ggagtcgtcg cttattctga aacagctgag cagaataatg agtgacaggc tggtggtggg 171900
gaggttgagt cttactccgg atttccatta aatgagtgca tggaatcaat agctaactga 171960
acatttgtct ttagaacacc caggggcccc tggggaattt ggtattttca gtctaattct 172020
cagacaggaa aatgcgcagc atgactattt tttaaaatag tttcaacatc ttttatgtaa 172080
tgctgatgca tctggaagtg aaaacgctaa gagtttcatt tcactaaaaa atggattttt 172140
tttggcttta acctttaagt tgaaatcaca attagtggcc ttttcaccat agtcataaga 172200
gtatcaaagt gtgtgtattc acccacacat caaaccagtg tttactgaga gtatattctg 172260
tgcaaagaat tgtgcagttt gttatgaaaa atacagagac ctcgctgggg cccctaagga 172320
gctcatagtc tagaaaggga gacagatcat tacacggcag ggaaaataca atatgtatgg 172380
gagcatgtca caaaggaagt gacatcgagc tgaatcttaa aggaagagca atgcttgaat 172440
gaatgaggac atccctgatt gaaggaccag cataatgaac aaagaatttt gccttatatt 172500
actaagattc catcagatgt tatgacgcaa acataagcat catggtaatg aaattaatag 172560
taaatttaaa taaaaatgat caaattaaga cttttttggt tttgtctatt ctaccttctc 172620
attttaatta tgttgcaaag aaccatatac ttagggtaaa ctggtcaata gctgtggcca 172680
tggaatagaa ttataattca atttaaaagg agtttaatag tctcatggta aatgaatagg 172740
ttacagctgg gcactgtggc tcacacctgt agtcccagtt ctttgggagg cctaggtggg 172800
aagattgctg gagaccagta gtttgagtcc agcctgggcg acatagcaag accctgtctc 172860
tactaaaaaa ttaaaaaaat agttgggcgc agtggctcac gcctgtaatc acagcacttt 172920
gggagaccac atgctggtcg agaccatcct ggccaacatg gagaaacccc atctctacta 172980
aaaatacaaa attagctgga cgtggtggtg catgcctgta atcccagcta ctcaggaggc 173040
tgaggcagga taattgcttg aacctggaag gcggaggtta tggtgagtgg agattgcgcc 173100
attgcactcc agcctgggca acaggagtga aactatgttt caaaaaaaaa aaaaaattaa 173160
aaaattagcc aggcatggtg gcgtgtgcct gtagtcccag ctacccagga ggctgaggtg 173220
agaggaccac ctgagcccga gaggttgagg ctgaagtgag ctgtcatcac accactgcac 173280
tccaacctgg gaaacagagt gagaacttgt ctcaaagaaa aaaaaaaaag aatgttatga 173340
atttagtatt tttatacttc ccctacaact ctagtatctc tgaggaaaag cctcaatcag 173400
aaaaatgatt tgctttgggg ttttatcttt tatcagtgat aaatgtgaat tgagaataga 173460
aatctcaaaa tgcaataatg atagtacttt atatttcagt aggacttaat atataaaact 173520
ctaatatgca ttatttaaat ttggccaata tgcaagagaa aagcaacata gggcagaatt 173580
atgagtttgc ttcgtaaaat aactattacc agttcattct gttcaactat gtactggtag 173640
catttgtaaa caattcattc ttattttttt tccaaagtgc attgcaaaat agtcttgcct 173700
gtattttcct gtttgcagtc tatttcatta aatttctgca attctaaatt agaatagcat 173760
ctaatagacc acatatgaaa tgtgcttgct attaattcag acattttatg gcatattcat 173820
tagtcaaatc cttagtattt atttatgaag tcacattact ctgtccagta attaacagaa 173880
gtggatgaat atgcatctct aatttttttt ttagcaaaag aaatagctta cagtaagtat 173940
ttataattac gtcagctcaa tgtttacagc acttgaatgg cgatatgtgt agtttctgtc 174000
atttagactt catagataat ttttgtacag aaatgctttg ttgttgatgc tttgcttcct 174060
tcacacatat atcacagatt accgaaacaa tcattagtcc ttcagttgca acggataaga 174120
ctcttcttta tccttaattt tctgagctcc tttctaggca ttttatgttc ttacacagat 174180
gctaatgcta attaatgctt taatatgaaa gatactggca aataaaactg ttacatttta 174240
cccataagtt gtaaattcag cttagttgcc ctaacaatac tgatagtgat aatggctgta 174300
caattaatat ttatggagtg cttccagtat actgagctct gtgctaaaca ttttacttat 174360
gtagcttagt taactctcgt aacaaccctg tgaggtaggt gttattagcc cgtttcacag 174420
atgaatttgt aatcattatg ccttaccaca tttaataata acattctcta ttaatcgtat 174480
atttcagatg cccagctctg gaactttgca gtatgaaacg tgtgtgtatg tgtgtgatgt 174540
atatataata tataagtatg tatatataat atataaatgt agattatata atatatatgt 174600
gtgcgtgtat atacacacat ttcttttttt tgttgttgtt aatttatgtg ccacgctgct 174660
gtacgaaact ctggggtact atgatgaggg gatacctctt tcttgccttt aagggactta 174720
ggttgtggtg ggagagatgg acttggttaa ggaacaagta caggaaaata tgataattgc 174780
tttaataggg ataggtacag gggttgtaga aaaatgagag aaaagggccc ccacttccca 174840
gaaggtgtca gggagttttt cacagagaag cgtccccagc cctgagactt gaagactgag 174900
tgagtttgaa aagatgatgt gtggggggaa cagaagagag aagggtgtgg agatgaggga 174960
aacaagatgg ggtcagggag ctacagggag ggacttggag gtgctgaggg tcaagtgcag 175020
caggaggaga gacccggctg gctggggtca gagctcaagg agccttgcat gttacccaaa 175080
ggaatgtaga tgtcatactc tgtgtgctgg aaaacgattt acagatgaat ccaatcaaca 175140
ctaattaaat cagtatgatt aagggatgac cttcctttct tcctaccttc ctccctccct 175200
tcctccttcc ctccttcttt ggctcattta ttcactcaga agattttatt gagtgcccat 175260
aatgtgcaaa gctttccatt gaatcccaaa gatgaaagga ggggtgagag tggacacagt 175320
tctccctttc tggagtttat tgattcgtgg gggaaaacaa gcattaatca atgaatcaac 175380
caaaaaatgt aaaagttaca aaatgactac tataaccagg gagggtcatt ctatacaagt 175440
gtgtcctagg aggtggtgac ctggctgagg aagtctccct tgagaagagg actgagctga 175500
gagctgaagg agaaaagaat acaaggtcat ttgatagaag gggtgggtga tttgaggaga 175560
agtcttagca aggaggaagt catgtgcaaa ggctttaagg cctgggaaag caaggtcctt 175620
ttaaggaatt gaaagtaagc cagccatgct gtagtgcaag ttggaagaga atgcaggttt 175680
tgggggccat gtttagaaat ggaaagccac tgcaatgcct taggcaggag ccaaggaagg 175740
tagtagggtg gcagggtgga cgcggggaga cgtgttaggg ggccagggaa agagtccaga 175800
tgagccaggg tggtgccgga gaggagcgga gggagttgag gagtatggct gcatggttga 175860
atatggggca taatttggga gaggaagacg tcagagtgat gttgatgcca tcactgagct 175920
aggaaacgta ggtgaggcag aatctattct gcttagattt ccagaaaaca ttaggggata 175980
gatgaggatg acatcacaat ggaatttaag ctatttaagc tcaaggttgg ccttgaaaaa 176040
tgagtaggaa ttttcttttt tttttttttt agacagagtt ccgctgttga tgcccaggct 176100
gtagtgcaat ggcacgatct cagcttactg caacctctgc ctcccaggtt caagcgattc 176160
tcctgcctca gcctcccggg tcactgggat tacaggcgcc caccaccatg cctggctagt 176220
tttttttttt agtatagatg gggtttcacc atgttggcca ggctggtctc gaactcctga 176280
cctcaggtga tcctcccgcc ttggcccccc aaagtgctgg atttacaggc atgagccact 176340
gtgtccagct gaaaaatgag taggaatttt ctaaatggca aggagaggca aagcatgtta 176400
atcaaaggga gtgtcatatg caaaggcaga ggcataacaa aaatagtgca aataaatgcc 176460
tacacatata caaaaggaga gttattgtgg gacccataca taattttgtt gatttcttga 176520
tatgctcata tccattttgt gttgcagtga ttctaagatc tgtattagta tgtagacttt 176580
gtgaacaggt aaacatgttt aagaattttt taagacatgg ctgtattaga tatcgaaatt 176640
cctctcttca ttttcatatc tttactttgg aattcatata tgccttttga tgttatcatc 176700
tgacttgttt ctaatgaaat ttagccgctt aggcaggacg tggattttag gtttctgctt 176760
agtgttttgg catctggatt tgggattact tagcattttt aatttactaa aataaccacc 176820
aacttacact cagttgaaat atgaacatgt cggtttcact tgagcttggg aattaaaatc 176880
aaagtacagt caaatccaaa acaaataata gtaattttaa gactaggtga cataaccctc 176940
tgggaaaaat gaggtgatag tgatttgata cttttttttt ttttgagaca gagtcttgct 177000
ttgtcaccag gctggagtgc agtggcatga tctcagctca ctgcaaactc tgccttccgg 177060
ttcaagtgat tctcctgcct cagcttcctg agtagctggg attacgggca cgcaccacca 177120
tgcgtggcta atttttgtat ttttagtaga gatggggtta caccatgttg gccaggatgg 177180
tctcgatctc ctgacctcat gatccgccca cctcagcctc ccaaagtgct gggattacag 177240
gcatgagcca ccatgcccca gccccgatat gttttaatac taactacaga agtgttggta 177300
gaaagatcag ccttgaagag atggtatagt actagaatcc taagcatgac ctctgtgaac 177360
tgttggctta agtactggct ttaacatccg ttggctgtat ttactgtcag ttttcttgtc 177420
aataatgcag aggtaaacat gattcctggc cacctcacag actgcagtgg agtggggcaa 177480
tgtgtgtaaa gcccttagca catggcccag aacatagtaa atgtttaatc aatgttcgtg 177540
atgaccttgg ccatcactga catcatgtct taactgagtt attaacaaag aggcatgtgt 177600
agtttcaaaa gtgaaagtga ggccggaatg gtaaatacat gcactgaatt tgcataattt 177660
tgtggctaga aggagtctta gagaaagaga gcatcaaatt cagcaatgtt tctgacattt 177720
tctatgaaga actgactgct tgttatttct tagaaatctt agaatcattg agcagggaag 177780
gaggggcagg aacgggatta ttttgatagt ggtgtcctca aggggaggag atggggtggg 177840
aagcaacccc tggccagaac ccactcatcc ctggggatag ggacctgctg tgtctctgcc 177900
tgctgagttt ttgacattct gatttaaaaa ccttgtgtgt gtgtgtgtgt gtgtgtgcgc 177960
atgcttgcgt gtgtgcatgt gtgtgtgaga gattatgcaa tatgatgttt cccgtttctg 178020
tgacttcagc gaatgtgaat gaagaccaca gaagcagcct aactcagtga gaatattgtt 178080
tttataatta caggtctagg cgttttacac tgagattctc cactgccacc ctttctactc 178140
aagcaaaatc ttcgtgaaaa gatctgctgc aaggaactga tagcttatgg ttctccattg 178200
tgatgaaagc acatggtaca ggtaaacatc tccaaaagct ttaaaggaaa ataattatca 178260
ttgagttgta aagtccccaa gatagtggtg ggggtgtata catatctggt cacacaaaca 178320
tacacacaca acatacacat gtctattcat gtagactcca ttttttccta ctgtctcttt 178380
tataaaaatg gaacccttgc ttttttatgg gaaaggaaat aacttctact tattttgagg 178440
tcactagtta ggatagatga caaggcattg ctgataattc tgaaggcatt tataaattta 178500
tagatttata aattcactta gagagacaaa catcaaatgg tagtagagat tgtagaagta 178560
gtagagatta ttaagagtat tgttcctctt aacaatataa ttctgaacat ctttcatagc 178620
aacagatatt tttctaccgt atagttatta atgattagta taccattgag taaacattct 178680
aaaatttatt taatttatat cccttctaac tggacagtta gccgtttcta atttttttgc 178740
ctttttattt tcttgagata gggtctcact ctgtcaccca ggctggagtg cagtggcatg 178800
attttggctc attgcagctt ccacctccaa ggctcaagtg atcctcccac ctcagcctcc 178860
caagtattaa tagctgggac tacaggtgca catcaccatg cctggctaac ttttgtattt 178920
ttttttttta tatagtgatg aggttttgcc atgttgccca ggctggtctc aaactcgtga 178980
cctcaagcag tcttcccacc tcagcctccc aaagtgttgg gattacaggc gtgatccacc 179040
acacccagac attttattgc tttcatgatg ccaaaaatat tcttatagct ctgtattagt 179100
tcccattaca aattatttcc ttaggctaat ttcttagcag catactggta aatgtaagag 179160
ttttcaagtt ttacggcttt tggtaacttg ttgccaaatt actttcagta aagtcatacc 179220
agtttgtatt tccagaggca gtttatgaga gcgtctactt aatacagttt tccaatgctg 179280
agaattttga aaacaaaaag agttttttgc tgactgatta tgcaaaatgg tgtttccatg 179340
tattttgggt tttgggggtg gggggggtca tttgtaagtc aagtaaattg tactgttttg 179400
tagaaccttc ctccattaga cagcagcatc cttgaaactt accagatttc gacatttcag 179460
aaataatatt aaatccagaa ggagtagaag ggtcctaggg aattttaagt tcttcctttc 179520
tggccaagta tttttagaca actatgaaat cactagatac aatcattttt cagtggaaag 179580
cataattttt catttcttaa aaagagcaaa aaggtattta ataaaaaaat tttattagat 179640
atgtatctga agttatactg ctcattagtt taaaaatatg tatgtgccta tatatgtatg 179700
tgtgtgtgta tatatatata tgtgtatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtata 179760
tatatatata tatatatgtc caatatcggg aacatgatta aatataacta tgttagtgcc 179820
atatgatgga aaagctgtag ataagattgc aagcttcagg ctgcctgggc tcaaattcca 179880
gctctgctgt tttcttgaag tgtgacattg ggcaagttac tttgcatgta aaattcggat 179940
aataatagta cccttctccc ttgggtgttg ctgcaaataa tatatatgaa atgtttaaaa 180000
tcgttaaaac tcctatttca ggagtattta atcatttgag aaaatgatca atatagaagt 180060
aaacaaatgt agggtattgg catgaaccat agtataatcc taatcttcca aaattacttt 180120
gcctctcttt cctccctctt ttcatcctcc tctagtatct acaaaaaggg tttagcatac 180180
ttctgaatgg atttaatttg tattagtgga gtaatcccag tcctggagag acttcctgat 180240
tcaagttttc aagtcagaga cccatttttc acagagcttt gaaaccatgg ctgtctggat 180300
cacctggctg ggggcaccct tggagcagcc gttgggtgag agcagagctt ccttcccagc 180360
cagggctgcc tagctcctgt ggtacagcaa gtgccttggg cacagagtcc ctcaccgtct 180420
ggcaccatat gtgagctgcc ctagttggct catctcttcc cgtcattact aaataagctt 180480
catttcacta aataaatgaa agagaaggta gatgaagaga cccccccgcc acacccagct 180540
cttaggaaac gcatgcttta tcctacagat gcatgaaggg gaaggctgta ggtttgtgaa 180600
tctcttgacc ctttggctcc atcgtaacgt tgaaaagtga aaggaaaagt ggtcaaagaa 180660
tcatttggca tgaaggagac aaacacagaa cgacgtgtac ggcttcagcc tctgcctttc 180720
actggttacc ctgctatgag cttgtgtatg tagacgctgc attcgttttg gccctaattt 180780
ctggtctaat ttgaacagct ctgtatttct cagcagaaga ggaatatctg aattcctaat 180840
taagacatgt tagcttaaga atacctcctt aatgtgtcat aaatcattcc cctgtgacta 180900
tgaggatgaa taagaaaaca aaacttggat ttatacacac atgtatatta tttcaacaaa 180960
attaataagt tcatagaggg agagaggaca acaaatgtgt tagcaaatat aggtcaggaa 181020
aagagttcat aatgttctgc cagattctga tgaggcacct catgagtgta ggtagaaggc 181080
ctcaagtaac ggtagtggga atggtaataa cactaccata tggaacattt ggtatttgaa 181140
tagcacttag cttcctccca aactacaaaa tcaataaaga ctcagagagg aagaaaggat 181200
tctcttgctg tggatcactg gctggtgtgc agaaatgcag acgtgttggt tgtcaagggc 181260
ttaccagaat aaatttctct agggagacag gagagtggga aatacttaac catattaatt 181320
gtgctgtgac ctcagatctg tggtcagcag tttttggttg tttccatata ctgcacatgg 181380
ttgcccacac catttttgca ttcatgtaca agacctatct gcaagaccag gcagaatcat 181440
tgttgaaatc ttagttcgca aagtcccatg gggactttgg ggtgtcttag gattttgcca 181500
gcacaaagtt aaagcacaac ttttgaattg tgagaaactg agacaaggtc tttaatttta 181560
atcccattca gtcattcctc actcatttat taatttagca aaggcctttt taggggcagc 181620
tatgtcccag tatagggctg ggcattgaag ataatggagg aaaacaagat tgacaaaaga 181680
ctggccctaa tggagtttac agttctcagg gagatacagt caacaccatc ataactggtt 181740
tgggggaaca ggggagatga actggaccat tctaaaagga ggcaagaggt gcatctgaaa 181800
ttggaaactg gagaaaccag gggagacaga cctgttgatc tggaaggcat agaacagaaa 181860
gaaccagaga atagtcaggg actgacaatg aggttgtgat tgttgacagc cggaccaggc 181920
caggaaatga agaaggtaag gagagaagcg tactgtctaa cacccctcga atgcacagtt 181980
gctagggcca gtaaagatca tcgggctact catctctcaa tttaggtaat gtaaatgatg 182040
catcttattg acaatccata tccttaagaa attgtgaaat gagtctttta ctttttataa 182100
ctctacaaac atgttagaaa gatggatgtc accgtgtctt tatcacagta tggtgatttt 182160
tcttaaccac ccaaaggaag aatcgaggtg caccagaaca cgtgtacctt gttctcttat 182220
taaccatatc ctttttctta ctttacccac tataattcac ctcagagagt gagattaatt 182280
atataattaa tcctaccttt tgtgcacatg cataattaac tttatttagt tcactttaaa 182340
cagattttag gttccagatc taaataatag cccctccatt tgtcacatct tgacctcttt 182400
actatttggt acccttccac tcagcattgt ttgtgggatt gtggttcttc ttaccttcct 182460
ccctccattc ctgggtgctt ttagtggtct cttaaataac aggctctgct cagagatttc 182520
ttttatctcc ttaggccttg acctgcattt ggtaaaggct gcatttttag cttcggattt 182580
actgtctttg acgaaccttt ttctctattg tatccctccc tggtcagctg ctctcttcgg 182640
gccctcaaac atccaccacg tactctaccc agatgttttc ttctttcttt aacatgtcca 182700
gttgagttgc ccatatcatc ccctactccc catccacaca cccacccagc acacacacac 182760
acacacacac gcgcgcacac acacacacac acacacacac acacagtgca ttctcgaaca 182820
tggggtcttt tccccttcag gcaccgtatg taacccaccc cgcccctcag ctcttaggaa 182880
atgtttcctt tatcctacag aaacacaaaa agaaaaactg tagggttgtg agtccctctc 182940
aacccttcga ctacatctat atcataaggt tgaaaatgaa atgaaaaagg ttgaaatgta 183000
catttctaag gttaagaaaa tcctactgat attaagtatt taaaacacag acttccccaa 183060
aatttatctt tcagcataaa tatgcccttc ccttttctcc cacccttcct tcaatctgta 183120
gatagcctcc ataattcata gccagtttgg gtaaaggcat tattttgaga catttaatga 183180
tttttttagg aaaagcgaaa aaatgtaggg tcaaagattc aagagtatat tgtgttttat 183240
atgtaggcgt agcttttaaa ctattttgga tactttaaag ttttaaaata acttaccagg 183300
cttctttatg aagcatttta ttctttgaaa gttttataaa taatatgatt tctggtgtca 183360
gtatggaaac attcacatag ttgtaataac tctcatgaaa taaggtagac tattccatca 183420
tctgtgttta ctcttaaaac acattagaaa atggttgata tcaaagctta caattttgtc 183480
tttcttattg ctaccctaaa gcagactgct gcacagacct tcccctgcta cactaatgct 183540
gctttcaatg ttggcaaacc atactactca aagtgcgggc aaaactcgag gtagaaatcc 183600
aactttcata cagctttatc aaaatgacag tattctatgg tacttttcaa atcactattt 183660
ttttctctta gaggttatca aatgaaatga agcatttaaa tatgttttct aaattcagga 183720
atgtgagata ggagagcttt tgacattata ggattcagcg gtggaagaga aaatgaacat 183780
ccagttccct ttctccctaa ctcaagatct gtgctccctg aatatcatta gtgcttctca 183840
tttcatcagt gttcaaatag tgaatcattc attcactgat tgttgaaaca actgttataa 183900
gatttggaaa taatatacag aacatcttgg aagtactttt tttttattag caagaagcag 183960
ctatatgcca aaagtattaa gaaggatcat ctcttcagaa taagtgagaa gtatatcact 184020
ggtaattttt tagatttttg ctgaatgttt tagtaaaatt tgggaaggta gttttttttt 184080
gagttggcaa ttatatgctg tccctcttgt tttctcttcc aaaataatca ttcttctctc 184140
tctctctctc tctaaaatgg gagccacaga gccactgtca gaattgtata catataaacc 184200
tgagaacatt gcctggcctg gcacatagtc aatgctcaat aaacatttct tgctactgta 184260
tctactgtgt tctgttcccc ctctgttcaa caccctgtat tttttcctgg tggagatttt 184320
cctgagtacc taaacaaata aacatagcca aacaaaacaa gaattcagtg ctgatgccgt 184380
gtgctttaga agctgggtct gtgcttgact tgactgacgg agatgtgata ctctgagtgt 184440
gtctgcagat aaagccaaat tcaaaattca agtgaaacgc ccttggactt gggaatgaat 184500
cggcgggtgg gggggggggg ctttgaccaa ggtactcagt gaccctgtgc ttccaagttc 184560
tccatctgta acatgagtgg tttgctctca gaggtttctt ccacctctaa aaattaccat 184620
cattttgcaa ccttgatgct ttaagacttt gaagtccctg tggaaaagaa cctatgaaaa 184680
gcggtcactg tttctgtttt ccccgtgcat tttagtggct gcatagagtg ttttttggtg 184740
tgtgtcttcc atcttgctca ggtggagcta atgacctcct tctccaggat agacaataaa 184800
acaaaccaaa acaaaaacac tctgttcatg cacaaaggca accctcttcc agatgcttaa 184860
ccccttaaat gagtatttcg atgacacaga gggatcatca cttcacttgc cactgaaata 184920
cagccatctc tggagtgaaa tttggcagct gggaagtagt caagctgcag tacttatatg 184980
acagtttggg gaaaaggagt gagacagaaa tagcagattc caaaataatc ccattaaaac 185040
agcagggaaa gtggaattgg gcaataagat gggaggatgg tttgccccaa agtctgactg 185100
tcctgtttag acaatgcgga cttcagcccc agaagctcta acttgtgtca ctgctggaat 185160
atagtgacca cagtcaagaa tcccctacac acaccccaaa aaggggggct tatctaatgt 185220
cccattgatc tatcgtcttg tgattttttt ttttttctct ttttcctgct actctagtta 185280
tcaggctgtg ctggcacata aatggatctg tctttttaaa gctacctctt ccttttgccc 185340
cctgcataag atagtgttgt aggtaagcat gttataacat cagaaagtac tcagctgaga 185400
aggagtgatg ttaaagcacc ctttgggctg gctctggaag gatgaactga ctgaccagaa 185460
aggaaaactc ttctgtttaa ttccaggatc ttgggaataa cagtgacaga gaaagaagat 185520
tcgagaagta gatgtggttg agtacaaatg tagaactctt cagattttct ggaatggggt 185580
agccattgtg ataaatatta ggatatgagc gtggaagtcg tagtggataa atttgaaagc 185640
tactcagcaa tatgtgcagc aacagttttt aaaaagcaaa aggaagattt gtcaacatag 185700
ttagaaatcc tcagatcctc agataatgga acatcatatc tctcaaaagg aagattccag 185760
ggaataaaga aagcagatga taagggaacc tgggcatttt agtttaacca gaaaatagaa 185820
cgttaccaaa aaatttagag attaaagagt cagtttcatt tagaagcaca taaaatgttt 185880
atgtaatgag cagaatttat agagtctact attataaaat agaaccaaaa atgaattcaa 185940
gaaaaatgta ataaaattaa tgtagtggga gaaaatgaaa tacaatatca gaaattctag 186000
ttttgaatct cagttctgca acttatcagc tttgtgacct tagggaaatc actcaaaatc 186060
tgagggtttt ttccgcatct ctataaaata gaaataatta taatatctgt ctcacagggg 186120
tattgtgatg atcaaatgag ataatgcatt gaaaatgttt tgtaaattgt agagccctct 186180
acatatgcta tttctataac tctgcaattt cttatggcat ggagtgagct ctcagagaca 186240
gtaatcacat gtggaaatag cttagagaag cagtcatatc agaggcaaaa tctattgtat 186300
aaaaatttaa aaattcatat gaattatttt ttctgcttct catttttctg gctcagaaat 186360
tcttctatgt ttacagaatt tttccaaaaa tattctggta agccctgtaa cagaattgtc 186420
cactctctgt taagcggtaa accacatgat tttttttcct tttttttttt tttttttgag 186480
acagagtctt gctctgttgc ccaagctgga gtgcaatggc acgatctcgg ctcactgcaa 186540
cctctgcctc ccaggttcaa gcaatccttt tgcctcagct tcccaagtag ctgggactac 186600
aggtgtgcgc cactgcacct ggctaatttt tgtattttta gtagagatgg ggtttcacta 186660
tgttggctag gctggtctcg aactcctggc ctcaggtgat ccaccctcct cggcctccca 186720
aagggctggg attgcaggca tgagccaccg tgcccggcca aaccacaaga ttttatagta 186780
aatattgcct gtgagtaaac cttgaataac aacattaaag cagaagactg ctatcttgtg 186840
tcatttgata atcctaattt agggaggtct gggcagagaa aagcggggtg tgtctgtggt 186900
ctggggacaa gagtaatgta agtagcatgc cacatgatga agactgaaac ggagacagtg 186960
aagcacggta aatctttact gagtgtgggc tggtgtgctg aagttccctt tatgcatcag 187020
cccatctgtc tcattagctt ctctcttaat cacaggctcc atgaagtgtc tacttgtctt 187080
tttttagctt tttatgtcaa tctcctataa aagcaaaagg aagtcaactg gcctttatgc 187140
tgtttgtgta tactccatgc atgctcgggg tggggccagc tgtatttata aatgcatgct 187200
aacatggggg ttactctgtg tgcataagag cttatttgta tgtgcattca tgaatatgtg 187260
tacatttggg cagatacaca aagacacaac acatatgtgc ctctgctgta tgctctctta 187320
catggaaaag acacattgac attaattaga aaaggtgata tgaaacagtg aaagtaaaat 187380
tcctttcggc agtatttact attgtaatta aagtgcatga tgtaacatta tatgtgcagg 187440
agaatttgct tattcatcct ttagaacaat agtaggagtt acatattaac aggtttaagt 187500
gtcaataagt gtctgaatac agattctcta ttgtgtgcag ttcttgtaat aaggcagtgt 187560
attttccttg tgtctttgct tgcttggaat tgaaaatgct ttggatgaag aatgttgcag 187620
agtgtaattt gtggcagaaa atatgccccc actgtttgtt tattattcct gaggacattt 187680
gctgggctga actatcatat gtagaaaaga acagctttgt ttggaaaata ctgtaagagc 187740
agtacaagaa aattgaatta agtaaagaga cttagggagt ccatctttct ctgatgatat 187800
tccttatttg ctcttcatta ttccctgtga aggaataaaa acgatgaaat tggatttgaa 187860
gactggatta agacaaatga cttttcagat tttttttttt ttaccttagc tgtttccaat 187920
tttcctagaa aagcacatag tcactatata aagagtctga gtttattgca ttaaatcttc 187980
ctaaatagtg tgcccttgag gtttgatgtg gggaattagt ttagaagatt caggggcttg 188040
gagtacctgc taactgtgtg atggcgtgtg tctctagaaa ttttatatgc ccattgattt 188100
ttatagagca agcagtacaa tagaagggaa gcaggatgct gcttggtctt aaggaagtct 188160
ttcctgccta ccaattgcca cacccctttt tctccaggta gagttgacta tgttttcttc 188220
tgggccattg ctgtacttgc ctaatacttt taataaggac ttgcaaatgt gcctgtaggt 188280
ctcttctaac taggctgtaa accactcgga cagaggaatt gttttatttc ttgtaactct 188340
aacacctaac acaaggccct caagataacc tgtcaaatga atgaacagat gagctgaata 188400
cccgctgtgt gcctgttctt gtcttaagac atgagggaca acctgtaaca caggacacaa 188460
tgtggctgtg tctgctctga aatggtagaa tatctagcta cagcttagaa taactgggta 188520
aggaaataaa tgctggatta taacccaaag aataaaatat ccaacgagtc caatgaataa 188580
ataaataagg gaaaaggaat gactcttccc tgcagcagaa tttcagttaa taaacaaacg 188640
aggaaggaag cagtatgaaa acatcattag aactcatagt aagaattgcc acgagaaagt 188700
cccaccgatg gatgcattag atgggcagat gtggattaga tggattagaa tgagcgggca 188760
aaagtatatg cagaaacagg aaattcgtag aattttaaaa tatccctacc ccaaacattt 188820
agtaattaca aggagaaaaa taaaagttta cggtgaagaa tcctggcaga catcacctta 188880
actgagtgat caaggttaat gtcaccagtg atacatattg acatcgtgtg tcccactgag 188940
aagggcgtgt catctctgat atcctccctg aaaaggcata atctcactct aatcaagaaa 189000
aaaatagcaa actcaaatgg aaggacattc gaaaaaataa ctgacccctc cccttaaaat 189060
tgtcaaggtc tttaaggata aggaaggatt caggaactgt cacagattag cagaaactaa 189120
gaaatatgac cacataaaat tctaagtatg atcctgaaac aggaaaaaaa aaaaaaaagc 189180
ctgtttggtg caaaaactgg tgaaatccta atacacccta cggtttgttg agtagtcgtg 189240
acccaggtta actttctagt tttgatcgtg gttctatggc tttgtaagct gttaatatag 189300
ggggaaactg ggtggaaggt acaagggagc tctgtactat ttttgccgct ttctgtaaat 189360
ctaaaattat cttcaaaaaa acctagttga cacttaggta ggccgaggtg ggcagatcac 189420
ttgaggtcag gagatcgaga ccagactggc caacatggtg aaaccccatc tctactgaaa 189480
atacaaaaat taggccgggt gcggtggctc atgcctgtaa tcccaacact ttgggaggcc 189540
gaggcgggcg gatcacctga ggtcgggagt tcgagaccac cctgagcaac atggagaaac 189600
cccgtttcta ctaaaaatac aaataaaatt agctgggcat ggtggcgcat gcctgtaatc 189660
ccagctactc aagaggctga ggcaggagaa gcacttgaac cccggaggca gaggttgcag 189720
tgagccgaga tcgcgccact gcatgccagc ctgggcgaca gagcgagact ccgtctcaaa 189780
taaataaata aataaataat acaaaaatta gctaggcatg gtggtgtgta cctgtaatcc 189840
cagctacttg ggaggctgag gcaagagaat tgcttgaacc tggaaggcag aggttgcagt 189900
gagctgagat ccggccactg cactccagcc tgggtgacag agtgagactc catcaaaaaa 189960
caaaacaaaa caaaaaatct agttcagggc acaataccaa tccacaggaa gcaattatag 190020
agcaatccat gacaacagac aactgagaat ttgtaatggg gtgccagtgt caggttcaga 190080
agaggaatga gaaatggctg gggattggag tcttcaggaa gagcttccta tgagaagcaa 190140
agcctgacag ggaccttaac aggatgtgta gtgatgatgg gtggaggaaa ctgaggggtc 190200
attgtaggca cagtggcagc agggacaaaa gcatgaggaa gggacacaga tggcctgcat 190260
gggatatgtt ggaggggcca gcggagttat atgtgcattg ctggagattg gtatgaaaga 190320
gaatttgaca gctgtgggga taacagagct aaaggatcac taagacctgg cggaggaatg 190380
tgaagttaat gcaggaggtg acacagagtt cccagttctt gtttatggaa ggggctcagt 190440
gagtttgtgt gtatatatct gaaaccggtg acaatgtatg tagggtggcc agagttggga 190500
gaaacagggg acaggcgagt caggaattaa agataggtaa tgggagccta ttcgtttgag 190560
ggtgttggga ggatggcagg aaaggaaaag ggggcaacat attcaaaggt atttgaaggg 190620
ataaaataat ataacttagt aattgttgga tttggagaat ggagaggaag gagtcaaaga 190680
tgatttctgg gtcatattta ctggacaggt actattggtg tccataactg aaataatcca 190740
ttcagcagat atttgcatgc ctacatcgag gaataatgta ttctaggtga ggaaggagga 190800
ttaaaaagaa tgtcaacaca gcatctgctt acgctggaat gtgggccaga aagcctgtgg 190860
cttaggctag actgaatgaa tggccaggtc agcctactta aggagtccct gccctccaca 190920
taaaaagaag ggaaagattg ccctactctg ttcctagcag tagccatgaa cagtgttaga 190980
agatctttca aactgacact tctgtcctct tgataaaaat gtcaggtcta ctgttggacc 191040
atactcataa aaactctgtt aaatcaccat tctacttagg aaaaggccat tcatgcccca 191100
cttaactctg ccaagataga ggatgctgtg ttcccaaggt accaaaactg aaagttaaaa 191160
tgccataaaa gtatactgaa ctttatagaa gaaaaaacag aaaaagtgta tgcatgctta 191220
aacctcaaac tcttgatctt caggtaccat gtcttttcaa cgtagataat atcacctagt 191280
gagcacaccc tgaagtcatg ctctggctgg ctttgctgtg ttctttttgt tttctcttgg 191340
gcttgtgtct cactctgtgt tgggtaggaa agggtttctg tagcctttat acccttgttt 191400
tcatcactta tttcacgaat ttccacttat tactcaagaa taaccatatt tttttatctc 191460
tatgacaagc tgaaaacctc cctgtcagca attatagcct gttagccctc acagagtcag 191520
tcttggggag gtatggcctt gcggttcagg ggcagaaccg taggtgtatt cacctgtgga 191580
agacttagac atacacattt gattatgggt ggcagtaatc agatttatgt tttgaaggtc 191640
ttcgaagatc tccgtccctt tctcagtcaa cattatacat cattgtttct taacagttga 191700
gtccttatac cttttttggt atcagtcggt cattaggcca agtaaacatt ttattgacaa 191760
taggcaactg aggagaaaat taaccctttt tatagttaat tgtaagtgga agttgcttga 191820
tattcttaaa aatatgaaat tgtggaagtt ctggttctag tctgagaatt gagcattgag 191880
catcaccttt acaacatgta gacttaaact tcaaatacct ttatgatgct gagaactccc 191940
catggaatag gaaccggcca tggcatatct aaaacatgac ttacatagca ttgcacgata 192000
taatatgaat gcatgttttt ttgtagaatt tagaaagagg ctgaacgtga tggctcaccc 192060
ctgcaatccc agcactttgg ggggctgagg tggaaggatc acttgaagcc acgagtttga 192120
gaccagcctg gacagcgtag tgagacccta tctctacaaa aaaaatttaa aacttagctg 192180
agcatggtgg catgagcctg tagtcctagc tacttgggag gcttatgtag gaggatcact 192240
tgagtctagg agtttgaggc tgcagtgagc tgtgatcgca ccactacact ccagcctggg 192300
tgacagaaca agtctttgtc tctttaagtt tttttttttt aattagctga gtgtaatgtt 192360
gtgagtctgt agtcctagct gctcaggagg ctgaggtggg aggattgctt gagcccagga 192420
gttcaaggtt acagtgagct atgattgcac cactgcacac cagtctgggt ggcaaagtga 192480
gaccctgtct ctagaaaaat aaaataaaag aaaataatgt ataaaagaat gacatctttt 192540
gtagagcgga cattggaaat ggcagaatac tccatgaagt agcctctaga ttccctttat 192600
gggcttgctg tggaagcaca tatgttcaca ttggcagaat aaagactctt tttatgtcct 192660
tttaaactaa tgtattgact tcagtatttt ttttataggg aacatatttc aaaattgtaa 192720
tggtagtcaa tggttctatg taaaaatact ttgtctttcc acagacccat atataccagc 192780
caggtcacct tcattctcag agtgcctgat gagtagagtg cattcaatac aatagctgtc 192840
ttgttttttt agcagcagaa gtgggagtca catgctgaac tcgggaacca ttttgaattt 192900
attctcatag caattgcaag gtaaaggcag gcagaatcct tgctgtgtaa ccctcaacag 192960
agctccataa ggattgggaa atcaggccat gctttgtcaa agagagggtg cacacaggca 193020
tcaaacaggt cacttctctt aattcttagg ccaccacaca ggaagcacat aattatttaa 193080
tccctggatc tttctagaga tgcaacaaag tgatgagggt ggacagctcc agaaaatcgc 193140
tgtgcaagga gcaagggtag aaagctaggg ttttggatta gacagactcc atttcaaatt 193200
acatcttaac ttagttttta ttgtaccctc taacaactta tgaataaaat aaggggaata 193260
tatagagagt taggcgtggg gaatggttac aacttatttc tcttcttcac tttcatctgt 193320
ctttcttcag tctcttctcc cctcttccat taaaggtaaa ctgaataaat gaatagtgaa 193380
tgaatgaagt gagcaagctg ttttcaacaa agttcacttg gtgccacttc catggattta 193440
gttataaaag tgatatgatc ctagttatct taggcagaat acatatttct gtgaccctaa 193500
tctacgtggg tcctacttga aacctggaaa tgataggaaa aaccttcttg ggaaggagaa 193560
aaatgaccaa taaaaaaatt ctgaattata cttatagatg aagccctggt gaacccagag 193620
ccctgttgac tcacaaggac actcaaagta agattagtga ttcaacacat tcacttcttc 193680
agtttcccaa atagattaga aggaataaga gggctttctt gggttaaact tactaaccac 193740
agtgaaggaa ggagaaaacc tataaaaact tgaagtatta taaaatctca gcggtgtgag 193800
gccatttcgt ttgaggacaa acaaacctag tggattgtcc agggcaggtg aatgtaaagg 193860
acatttcctg agatgcaaca aagagatgat ggtacaatgg gcaaggatgt tgcaataaca 193920
agcaacccca actcttcagg gtggaacaca gtagaagttc ctttttgatg gtgttacgga 193980
taacttgggg tgttctgcag ttggagaggg cgtctgtatg gtggtgattc cctgacccag 194040
ggtccttgta tcgcaaggct cagacattcc ctcagtgttg ggagacccta aggatcttct 194100
gcacctggca gaagagagaa gtggggaagc gagagagtga gcagtctcct gggaggtttg 194160
ttggtgaaat tggcatatac cacttccttc catgttccct tgaccagaat ttagtcatgt 194220
ggacatagtc aactgcaggt aaagtggaga attgtcagcc tgtatgtcaa ggagtacagg 194280
gaaactgttt tttcaacaac taaccagttt ctgccacaac tggatacctt cctgacgtca 194340
tctttactcc catcccagcc ccacccgaga tttggccatg agtaccctgt aatttgcagg 194400
gcattatatc tctgtctcag gaacagcagg agaccactga gtcaatcgga actgtttttt 194460
tttttttttt ttctgagacg gagtctcact ctgtcgccca ggctggagtg cagtggtgtg 194520
agcttggctc actacagcct ccacctcctg ggttcaagcg attctcctgt cttagcctcc 194580
ccagtagcta ggattacaag gctcacacca ccatgcccag ctaaattttt tattttttat 194640
ttttagcaga gacgaggttt caccatgttg gtcaggctgg tctcgaactc ctgacctcag 194700
gtgatccgcc caccttggcc tcccaaagtg ctgggattac aggcgtgagc caccaccacg 194760
ccaggccagg actcttcatc ttttaaacca cccgggtctg aactgacagt cccttatgtt 194820
atcttcatgg gaagaagagc aggcagtcat gtgtggctcc ccatgaaaag gcaaggaacc 194880
ttctagatac tgccgctaga aaccaggtgt gggatagaag ccctgccttt gatctatacc 194940
tgttggtcag gaacctgctt ctactttact tcattcatct gcacttctta ggagctgggt 195000
cctgttcttg tttaccatta ctaaattacg gggaaattcc tgaaattatc cagtcctccc 195060
agatggttca ttctttgtgt gtatacccag agcttggtca tgtccccatt cctctctctc 195120
aagattagat ctgctgtcaa aacctagaaa caagtcttta ctgaactgaa ctctttatta 195180
gcctttgatt gccagataac tggacttggg aaggggagtt tgggaaaaag ggttaactat 195240
attaaatttt tttggtgctc tcttatatgg gctgggatga agcatttaga cagtgggaga 195300
agtataggag aggcagacag atgccagaaa aaaaaaactt tggttgtttc caggtaccga 195360
aaaagaaagt tcatttgtaa gtcacccacc tcctcatgat ttcttcacct cctgtcccct 195420
gctcatggta ctagagtttg tctatattat aagctctata gctctttttg ccttcctgca 195480
aaactaagca ctatttataa cactgtttct ctgagaaaat gtgtttggag tttcaaataa 195540
atgacttaca aatgaacttt ctgtatacaa ctcattcata cattgagaac tgcctgtacc 195600
gggcatgtaa cctggagata acttttatct ctgctttatc aatatgggct tgtcaggttg 195660
acttatgtgt acttctctct gccttcgttt tgatgatagc ctctctctta aaatttaata 195720
ctctctttat gtttggagaa acattccctt tggcagcgtt tcaaatattc ttgcgaattg 195780
gaatagtgat tttattttat ctcccaatgt atctttaata ggattcatgg ctatgaaaat 195840
cttttgcaca gtccgcctat aaattgtaga aaaattgaga actatttaaa agaagggggc 195900
gcagaaataa tccttttcta gtattactct gggttgtcag atatctttgc aatataatta 195960
ctgtgttggt ttttaaaggt taaaagagct ctgacgttta taattctctt ttgtgtgtgt 196020
gttctacaca tataagggga aaatctaaca catggaagga aaatacttta gttaacataa 196080
aggtcctgag cattttatgg tttttcaata cagagacata attcatggat tttatatttg 196140
cttttacaga tatctggtga atcagttatt tgctctgtgg aaccaatttg cagtttacac 196200
accttgttta tttctaagct gtgtgcatgg gtaatgtgtg cacaaaaata ctcttgctga 196260
cattagattg taaagtaaaa aggcggaaca ctggtcctgg agatatgcct tctcagggaa 196320
cttactatcc atatacaagt aaaaatttct cattgttagc agagcagctg acagaatatg 196380
atcacaaatg ttgctgatgc tgttctgtta ggaggtagaa atagaatgcc taggactatg 196440
caagcttgtc agagttagat tgtcagggtg atgtgcttcc atattaaaaa gaatactttg 196500
ttcccccctc acacatgcac ccttgcagtg gaaagaaaca tttatttcag aataagcgca 196560
agttattctg acttgcactc acaggctcag actttgatgc cagtgtagtt aaaatttagt 196620
gaataccagt catgtttaat ggtctttccc ttctgtttaa aacagtactg cagcccatgc 196680
aagaaacatt tccctttaat tttatgcatt ttgtggtatc ttttgatggt ttttctctac 196740
tgtcaaaact gtgagaataa tttcaatggc atgttttttc tgccatcttc agttggcagt 196800
catatccccc cagattgtcc tcatagattc cagatcacct ttatgtttaa tcttcattaa 196860
ttgacaagta cctttgaaag ggttttgcaa aaattgaact gcaaagctgt gatttaatac 196920
aaggaaggct acatcagtgt gaaagaaagc actttatgaa ctgtagagta ctatttaaag 196980
gtgaggcatt ataattaaat atgctcaggt tgttactgag cattgaatgc caaagcatat 197040
gaaagacaac ttacgatgcc aggagtttga gactagccta ggcaacacag tgaggaccca 197100
cctctacaaa atgtttttgt tgttgttgtt gttgttgttg tttttgagac ggagtctcac 197160
tctgttgccc aggctggagt gcagtggtgt gatctcggct cactgcaacc tttgcctccc 197220
agattcaagc gattctcctg cctcagcctc ccgagtagct gagattacag gaacccacca 197280
ccatgcccgg ctaatttttt tttgtatttt tagtagagac ggggtttcac agtgttcgcc 197340
aggatggtct tgatctcctg acctcgtgat ccgcccgccg tggcctccca aagtgctggg 197400
attacagtcg tgagccaccg cgcccagcct gtttgtttgt ttgtttgttt gttttttaat 197460
tggccaggca tggtgagatg tgcttatagt ccagctactc tggaggctga ggcgggagga 197520
tcgcttgagc ccaggagttt gagattacag caatgttatg agagtagcta gaagttacac 197580
caatgctgca ggagtttggg ggaatccaga gttgtaaaat gccaacaaaa attattaatt 197640
aaggggatct cttagccgtc tctttgaccc tacaaaaaac atggtggtac tgagtttttt 197700
agcctcaccc aagcaaaaac agaatagggc attgtatttc ttatatctgg atgcaaaaac 197760
atgaaatgtt aattgtagat tataagtcat taagtgtcac ggatttatgt tttatgacaa 197820
gttggagttt acagatttct aggctatttt tttcacatag agatacatga aagctttatt 197880
cttgttattc aacgtaaatc ttttataatc tgctctcaat ttccagtatc ctgaaaaatc 197940
ctttttctct cttttttgag acccttccct ccccctacca tccagagtca tgcagttaac 198000
agttctgata gtgcttggat tcatttgtag attgtacata ccaaatggag ctggcacctc 198060
ttcatggaaa ttggacccag tgggctattt tacacttgcc ggatgtgctt tcctcagtag 198120
aagtttatat tttatagctg atactccatt gaccatagta acctgttata aaacatgatg 198180
ttttatcatt tgttctgtgt cttcagggct gaacatttta tggagagact ttattaacat 198240
ttaaagagac tttattaacc ctagatatta acatggttta cctggaaatt ttttgagcaa 198300
tgttttcatt tgattcctgg aatgttcaaa tagcaaaggc agtttctgtt ggtgtgcatg 198360
tgtgtgtttg tggttaaaag ccagcattac ccagagacct tctggttcat gtggaaatta 198420
ttattattac tatgattatt gttatttttg caaatgaata aattgtcatt ctgatttttt 198480
taacctcaac gttcctttaa aaacactgtt gatttttatg gagaaggttg atttcctgga 198540
agtaataata tgatgttaga gattactttt taggcaatat tttggcatgt ttatcagata 198600
aatcaaacat caaataaata gattatgggg aatgattttt cagtaatctc tttttgcagt 198660
ttcttcccta aacaaaatga tgtggcctat taggtggatt ggtttggagg acaattgctt 198720
acagggaccc tgtccttatg gtgtggagaa gcagaaaaaa ctcacagtac tccagagtag 198780
cccccttatt ctttttcata aacttcaaac taggtatgaa agacctgtcc actttaaagc 198840
tttcgcctgt gaagataaag cagagattga tttttaacca ctatgctcat atggggaaac 198900
agaatgcagg agctaagatt taaagaagca gatgggaaga agagaaataa cctcctctgg 198960
catccacctg gaaatgtctc ctgagaaaga ggatggacat cttctgatat tcataagtca 199020
aggaactgct tgaattctgt attccgtgta cagtattcta cctatcaaga ccctcaccca 199080
gggaagaaag tcttgtttat tcaggagatg gggagcagga ggcattgagg actgcatagc 199140
ttatttaaat taaaaaaaaa agtgcaatga attgcttttt agtgtattta cagagctgtg 199200
cagctatcac cacaataaat tttagaacat tttcatcacc cctaaaggaa atcccatacc 199260
catcagcaat cacttcccat tttcccccaa tcctctaccc tcagctcctg gcaaccacga 199320
agctgtttct ctatatatag atttgcttgt tctagacatt ccatataaat agaatcatgc 199380
aatatgcgga cttctgtgac tgacttcttt cacttagcat aatgctttca aggatcatcc 199440
acatttcagc atacatcagt cattcatttc ttgttatgat ggaataatgt aacattgtat 199500
ggctatacct tattttgttt attcatttat cagttgatgg acatttgggt tgtctccact 199560
ctttcactat tatgaacagt gctgctatga acattccttt ccaagttttt gtgtagacat 199620
agtttcattt ctctgtgcag cctactttta ggtagttaca aattaagatt gtaagtgatt 199680
tttttttcat tttacacatt tgttcgcttc acgatggcct cctctctctt cttacctatc 199740
tcactctccc aaaaatgatt tttcttgaga acatagttgt agaagggtaa gaatatcaac 199800
caacttttgc taagtatgaa tgcccaggcg ctctgctaag catcatgtat gtgttacaat 199860
gtttctcact ttatagacgg gggctgaggt ttagagaggc tgctaagcct ggaggtcatt 199920
cagctgaaaa ggtagaagag ctgggatttg gacccacatc ctgtttactc agcaaggtcc 199980
atgctgtctg ttgactccct catgatatga tcccagatca tacacctgtt gaaatcttag 200040
agaattctct ttctattcgt gagcttctcc caattgtatc ctaaaaagta aggaatataa 200100
atcagatgct ccgtcctaag cccttggacc tggagcgggc atttgtgttc cccgttgaca 200160
aaaagatgat gaaatacttc ctctgtgtct gagtgcagcg gcgtcatgga ccggtgttaa 200220
gtttaacctg acccttctct ctgccctgca gttgcttcat ctcctcacct taagacttca 200280
cctttccttc atttcagctt cccagagata ctgccacacc ccggacctgt gtatcaactt 200340
gaaccctcac accccccaac ttggaccttt ctaaatctta aaatctcaga ctctgtagtt 200400
ctctctgggc atagcctcct gacccccttg ctttccctct cttcctcaga actcagttgt 200460
ctccttattg tgagccctga ctcatccccc actcttggtc actatagcca ctttcttcag 200520
gctccgtatt cctgccccct aaccagccta gacctcatgg cttgaaagtt taactgtgca 200580
tgcccaatag cttagtgcca tgcattcctt tccaggcacc aatcctgcat gatccccatc 200640
acctgcacag ctgcttagag gcccccaaac ccaactgatg ggtcctgatg taaattctta 200700
ctgttaatct gaggagagtc atcattgctt ttctagtggg ctcatagtca catttcttat 200760
gggatctatt ccaaactttt ccagtctctt caaaacttac cctcaccctc actttggtag 200820
aggaccattt attcatcttg cttttttaaa atcttgaaga atccaggcat gaatccttct 200880
actctctttt tccctttaat tctgtccgtt gctcctgtct cacagttgca gacaagtgtt 200940
gcatgctgtg ctcacgcatc ccagaggagc aagaagacct cccactccgc aaggctccaa 201000
gacccctcgt tttctggatc cctctctacc ctgacttctc tgaggctttg tcacctaggt 201060
tatctccctc tcctgcttga tctttcatta tcttcatctt aaccaaaacc ttctcttcag 201120
tctatgaatg tgcctagtgg tgtggcctgt cttttaaaaa ctaaaggagc ccttattttg 201180
accttgttct cctcaggcaa tttccatttc tctattcttt ctttaacctc aacatgtttt 201240
gaaaacatag tctgtgttct attcatccag attattacca cccactgaag tcttagtcac 201300
cagttcttct ctgtcatcca agcactggaa acttctcggc ccaatgtctt cactggccta 201360
agatggactc aaactagtaa gcttttattc agtggttact cctagacctc tgggctgtat 201420
ttcctacggt ggctgctgcc agccatttca tttcttttct tttctttttc ttttgtttct 201480
tttcttttct ttttcctttc ctttcctttc ctttcctctc ctctcctctc ctctcctctc 201540
ctctcctttt ctttcttttc ttttcttctc cttccccttc cccattcccc ttctttcttc 201600
tttcttcttc ttcttttttt ttttttttga gacaagatct agctctgttg cccaggctgg 201660
agtacagtgg ggtgatcttg gctcactgca acctctgcct cccgggctca agtgatcttc 201720
ccatctcagc ctcccaaata gctgggacta caggtgcagg ccaccacacc tggctaattt 201780
ttgtattttt tgtagaggca gggttttgct gtgttgccca ggctggtctc caactctgag 201840
ctcaagcaat ccgcctgcct cggcctccca aagtgctggg attacaggtg tgagccactg 201900
catcagccta tttgtttctg aaaacactct ttatctgcct ttattttctc ttaccctcta 201960
ctgctctgat catttcttct ttatgtcttc cttcttttgt cccttttcgt acttattctt 202020
aaaagtagat tctgcctaag tgtgtataac cacttttctt ccttgtttac atcttccagg 202080
tcctgaggga gtgttgtgac ttggttacag cctaccttcc taaccttact cattgcagcc 202140
caggcttccc cataattata tacatgttcc tctcacacct caagctccct tggttttctg 202200
cttctgttgc atctctggtt tctttcacct aggatcatcc tcctgcctcc cctctctgca 202260
tttctatata ttcttttcca ggaccacatc aaattctgtg ttctccttat gacataatct 202320
caaatgaccc caggaagtta tctttttttt ggtccacatt tttaatggga cctttcttac 202380
ttttacttgg ttttcaaatt atttgttgaa acacatttct tttaaactat gtactcatga 202440
gacagtatat tgagaattta acccctgtcc ttaaacacag taaatattgt gtcaatgttt 202500
gctaaatgaa aggagtgaaa agtatggctc tatgggaact tgttggtgaa tgtcccattt 202560
ttatttacca atgaagaaaa gcaaaactta gcaaaatgta tctgtggaga ggtgggtggg 202620
agagggttgt tgtatagtct gaaccaaaat aattaactcc tgtaattgca aaaatattat 202680
cattgctcag tgcaccattt tgcagttaat cagatagttt tagggaaata ttaaatgatt 202740
ctcaagcttg gaaaatagca atgagtgtta tggcatcact atacagccca gaatgaactc 202800
atggatcctc caatctcttg tatcagatat actgcatact ggatacccaa ggcatcaggg 202860
attcagagaa atttttccga aggtcatctg ggtaggaagc ctgactttta tagaatattt 202920
cataaaattc tttttatttt atttttcaat agtttctcta cattgtatac aaagcacact 202980
aattactcac tcccattgtc tccactaatt acatcactcc cattttgttc tcctatgaac 203040
aaagaagaaa ggaacaagag gttgtttttt cattttgaag aggcaaggtt gatatgtttg 203100
actaaaataa agttgggatt acctgtgaat ttcagccagc tttgccctcc ggtccatcag 203160
gtggacagtg gaaaattgac tgtgatgcta aaaatggtca taattggggg aaagtaagct 203220
ttaccacctc ttttgtgatg ctgaatgtgt cttcaaggga atcaaaaaag ttgtgcttga 203280
caggcaaggt gaaaaaccca gggatttgct acaagaatct ctgcaggagt ggtagaatga 203340
gaagcttcat tggagtctgg gacattttag tgttgctggc ccattaccct gaacactctt 203400
ctaacctcct ccaagacggg tgtctgagag gagctgggcc ctgcagacca attctagtct 203460
tctctctcca cccctgcccc ctttagaaca agcatattaa aggaatgtct gatgagctca 203520
ctatagtctt tgtcaggaca ttttattttt tattttttta tttttatttt tgaggtggag 203580
tttcgctctt gctatccaaa ctggagtgca atggtgtgat ctcggtgcac tgcaacctcc 203640
gcctccccgt ttaaacgatt ctcctgcctc agcctcccga gtagctggga ttacaagcac 203700
ctgccaccat gcccagcaaa tttttgtatt tttagtagag acggggtttc accatgttgg 203760
ccaggctggt ctccagctcc tgtcaggaca tttttacagc tgttttcgtt ctaaccctaa 203820
ctgatgacca ttggaagacc taaaaattca gctacgcaga ataagtaaaa ttggtctttt 203880
tctttgcatc ctgaggataa atctaaacaa acccctctcg ttggcatatc tccagctaca 203940
acagagggca aatttgaatg gattatgaag attgaattat ccacttggtc ttggaggtgg 204000
tcccgtctcc tgtgatggtg gggtggggag gcggtgcaga catgtgtaca ggaagcttag 204060
ccaaatgcct ctatttggga aaagttgaaa tcagtttcct gggcagtcaa ttttgagggt 204120
ttaaaaaact ttattttttt tttattaaac atactaaaaa taacaaagct atccaaaatt 204180
agaccacgta ctttgctcct tttatatttc agtgtccttg gtatgcttgg tttcttttct 204240
ttctttttga agcattaata ttgttttgaa ttgctagata tacagaaggt acgatagatg 204300
tacaaggaaa aataagcatc tctcttattt ctgtgtctaa gtcacttgaa ttctcaccta 204360
gaagcaagta ccattatcat tttcttgtga gtccttttaa ggatatttta tgattatata 204420
agcaaaaata taggtttttt aaaacaatgt ttacacccca tacactattc tgccctttac 204480
ctcttttcac ctaacagtgt gtcctggaaa acctttctta tcggaacata gaacagcctt 204540
attctttttt agtatctaaa tagtattcga ttgtatgatt ttgccataaa gtattcagtc 204600
ccacattgat ggactttttt tttttttttg gttgtttcca gtcacttgct actatgaaca 204660
atgcttcagt gaacaactct ctataaatag catgttgtat gtcagcaagg atctctggag 204720
gagaaattac taaaggggaa ttgttggatc aaaaggaata tgcagtttta attttggtaa 204780
accttgccaa attgccctcc aatttggcat tcgtcctatt gtatgttcct gctagcactg 204840
tttgagtgtg cttttctcca cagacgatgt ttttaaactt cacgatcttt gccaatctga 204900
gaggtgaaaa ctactatatt ctagtagctt taatatgggt ttctgttatt atagtggtgg 204960
ttgaatatac tttcatatgt ttaaaagccg ttcctatttt cttttctggg aaatgtatat 205020
tcatcctcgt tgcccatttt tctactacgt ttttggttta tcctgtgaat tgactttttt 205080
ttttaggagc atgtaacagc taaaaagatt agtccttttg tcttatgcta ttttagttta 205140
aatttttccg tttgtctttt gactttatgt tttcttcatg cagggtttta aaaaattaaa 205200
gtcatcttat ttatcagatt tttatttttt ggcttttaat ttttttacat acttaggtct 205260
cttctacgca gtaattataa tttttaaatt gtctcgtatt ttttattagt attttaaaaa 205320
taatagtttt ggccaggcac aatggttcat gcctgtaatc ccagcacttt gggaggccaa 205380
ggcgagagca tcacttgagg ccaggagtta gagaccagtc tggacaacac agggagaccc 205440
tgtttttaca taataataat aataaatagc caaacatggt ggcgcacgcc tgtttgtact 205500
cgggaggctg aggtggaagg attgtttgag cccaggagtt tgagactgca gtgagttatg 205560
gtcgtgctac tacactccag cctgggtgac agagtgagac cctgtctcta aaagaaaata 205620
aaaattaaaa aggttttatt gagatatgat tcatatatcg taaaacttac cttttttttt 205680
tctttttttt tttttttttt gacacaggat ctcgctctgt cacccaggct ggagtgcagt 205740
ggtgcagtca cagcttactg caacctggaa ctcctgggct caagcagcct cctgccttag 205800
ccttctaaag tgctaggatt acaggtgtga gccactgtgc ccagccacaa tgcagtcttt 205860
taataaatgg gtttttaatc tattcataga attatacaat catcatcaaa acctaatttt 205920
acattttcat tactccaaaa agaaaacctt tacccattaa gcacccactc ccccatttcc 205980
tctaccttct ggcccctggt atccacttaa tctatgtttt atctctatgg atttgcctgt 206040
cctagacatc tcatataaat ggaaccatat aatgtgtggc cttacacaac tgacttttcc 206100
acttagcgta atgttttcaa ggttctttct catattttta tgctttcatt ttttacgttc 206160
aaatctttgg tcaccttggg atttatttta gtgcaggatg tgaattaggg atctatattt 206220
ttttaggtgg ccgtccaatt attggaagtc cttcctccca ctaaagtgca gtgacaccca 206280
tatcattcac tgaagtccag tattcatttg gatcgacctc ttttctgttg accttgctaa 206340
gtattcctgt gcccatgcac actgttttac tttctaaggc tttataatat ttttaatatc 206400
ggtatggtat tcttttctta tttcttttta tatcattgtt atggccattc tttcctgttt 206460
atttttccat aggaacttca gaattagctt tctaatttgt atttttgaca tcatataagt 206520
ttatagataa atatagaaag aattattctc ttgatattga ctttctattc aagaagaaga 206580
tagacctttg cagttgttcc tatctcctcc tctgtccctc agtagtattt aacattcttc 206640
tttatgtaga tttgtttttt tttttttttt ttttgaaatg gggtttcact ctgtttccca 206700
ggctaaagtg cagtggcaca atcttggctc actgaaacct ctggctccca ggttcaagcg 206760
attcttgtgc cttagcctcc ccagtaactg ggactacagg tgtctgccac cacacctggc 206820
taattttttt gtatttttag tagagacggc gttttaccat gtttggttag gctggtctcg 206880
aactcctgac ctcaagtgat ctgcccacct cgccctccca aagtgctgga ataataggcc 206940
tgagccactg cacccagccc tctttatgta gatcttgcat atagtcctcc ttcagtttat 207000
ccctaggcat tttatatttt tgttgttatt taaatatggg ataccttttt actggttgtc 207060
ctttagaaag gttattgatt tttgtatatt cttttgtttc agttacccta cagaattctc 207120
taattaataa gttgttcaat tgacttgctc agatcatagc atttataaat aataattttt 207180
ctgcctgtta taatttttat atcccttatt tatttctctt atgcagttaa attggctaag 207240
tttaacagat cagtgttaaa taacagagat gatggtagac atcctcatgt tgttcctatt 207300
tttaatggga tgcttctcat gttcccccat taacagtgag cctgcctttg gggtggagcc 207360
tgtttattgt ccatttggcg tttgtagggc ttttataatg agtagaaaac gttttggaaa 207420
tgctgaatct gacggaatta tttgcagaaa ggtaaagtat gctgtgttag ttctcccgca 207480
gtgataaaat agtagtctga tttttcttac cagcattgac aggagtttat gagtgggaag 207540
tctgtgctat aaaggaagaa ggcagcaatt gtattttaat ctcatgctat ttttcttttg 207600
ccaacgaagt aaaaagacta agaagctata ggaatatgta gtaaaggctt ttgctaagag 207660
agaaaaggaa gaaaggtgga agaatgggat ggaagaaacg agataaaagt atacctcatt 207720
ttcctcagcg tccccccaga tcaagtcacc tgataaacca aatattacta gggtagtttt 207780
tttccccaaa atattattac caaaaaatga cacaaaacac taattgtcaa ccaaaatgat 207840
aaagagtctc cgaaaaggct tgcaagaaaa tagtgaaata ttttatcatt tgtaagcaaa 207900
agataataat acagagttcc aaatactgag aaaccacaag aggaaaaaga atgcctattg 207960
aaacatgttt atatgttgat tctttttgat ggtgccatta aagaaaaaag aatgttttga 208020
tctcttgcaa agaaagccaa actagagagg tattttatga gctaacccca aacctgacat 208080
tactctagta ataaatacca ggacaggctg tcccttgcat tagcagaact ggaaaacaaa 208140
acaaaagaca gtaacaattg aggctttgat gcttgttgga aacatctaac atacagagtt 208200
agtgtgttgt ggtcataaac aaaaggagtt taggctgact ccataaatta gggaaactga 208260
tgcgtcctgt tgcttgggac acactacaca attatctgca tgacaggcag gaaagaaagc 208320
actggaaggc aaacagactg cagaacaatg tggccaccca gttggtttta gacacacaca 208380
cccctggcct gcagaggtgt ctatttgaca gccggtctca tgtcaaaact ttcttttatg 208440
tgattttccg attgtaggaa ccactgggct ctgggtgggt gtcttaggcg agtctgcctt 208500
agtgttgagt ttgacatatg gtagcattgt taggtggtgt gtttaggaga agccaaccag 208560
ggcctcagag ccaaaagcat ggagctcact ggctgtgtga acttgaccaa gctactgaac 208620
ttttctgagc ctagtttgtc atctgcaagt aatgcctaca gttcacggct tttgtatgta 208680
cttatgagat gttgtacatc tagcacctca catggggctt gtagagagca gttgctcagg 208740
cagtgtttgt aagtggagca caggaagcaa gggatggaaa gagtatcaca tcaggaccaa 208800
ggatgaagga gtgtttgtag gaaagacctc cgagatgatg gttgagatgg attatgtaca 208860
ataaacagga agcatgttct tgggaagtgc ttctaagcat agaagggcag cattttcaaa 208920
ggcatgggtg tggaggaatc tttgaaaccc agggaactgt agtagagcat ggctcagtcc 208980
cagggtatga gatggggagt ttcactcatt gagacaggac agatgagcca gcgtgggatt 209040
gagtggggac tcgtgtatcc tgttcagact atagtcacga tgatggagag tcgttaaagg 209100
ctgtagacat ggccaggcat agtggctcat gcttgtaatc tcagcacttt gggaggctga 209160
ggcgggtgca tcacctgagg tcaggagttc gagaccagcc tagccaacat ggtgaaaccc 209220
tatctctact aaaaatacaa aaaaattagc cgggcgtggt ggcatgtgcc tgtaatccca 209280
gcactttggg acgctgaggt gggtgcatca cctgaggtca ggagttcgag actagcctgg 209340
ccaacatggt gaaaccccat ctctactaaa aatacaaaaa aattagccgg gcgtggtggc 209400
gggcgcctgt aatctcagct actcaggagg ctgaggcagg agaattgctt gaatctggga 209460
gctggaggtt gcagtgagcc aagaccgcac cattgcactc cagcctgggc gacaagaacc 209520
aaactccatc tcaaaaaata aaaaagctgt agacatgagg gacagcattt catttgcatt 209580
ttggaaatgt gacagtaatg tctctcgggt gggtttagag attggggagg aaatgagctc 209640
tggcccaggg taatgatttc ttccatattt tccacaaatc ttagcacagg gctaaacgca 209700
tagtagattt ttagggaaaa cctcttgatg gccttgaaca aaagttattg ttttgccagg 209760
atcatctttt ccatgaatca cttgttatac cattagtaga ttattcttgt gtggagttga 209820
tcattttagc ccccaaatta tttttgtccc tcgattacat catcttaaac gattgtgtgt 209880
tgtggcatag acatatccta atctacttac aatttatggt gcaagtatct gtgtcataaa 209940
agatatcttc ttctttaaaa tatgctagcc tagcactcca tgaaaatgga gactcacagt 210000
gctgccctgt ccttcaaaga tgtttatgta caaagggata actgttccca cccctaaatg 210060
ctttaggctt tgcctatact gcctttcaaa gctttcccta ttttaagatt ttttgaggcc 210120
ccttggatct ctggaaggag aaagctataa tagcttttgg tttctgattg tctttaagca 210180
gagaaaactc acagtctcat ttaggggcgt gacacattcc tagtagggat ggtcagtccc 210240
aggcaatagc tgtggccatg ggctgttgag ggccatggtg agggcccatg cggtaacaga 210300
cagtggtatg catgctggac tggggtgagt aaatagccat tattcagaac cacggattct 210360
attttcaatc agtctgtcaa ctgatatttt tgagagtctg ccatgtacca agcagagtgc 210420
taagttctga agatactaag gtagacaaga taaaaatggc ccctacccac atggcactac 210480
attatagtta ttataggaga gtggatagaa catatctagt caattaccgt gcactgagaa 210540
aggtactgtg agacggaaat acaaagtatg gtggaagcat cctggagtga caactgaccc 210600
tcacttggaa ggccatgcag gacttccatg agggtcaaga gtttcctgaa cccggacagg 210660
agcaagatct accttagaga ggtttggggt gaaataacgc catgaaaggg atagtcttta 210720
atctagaagg aaaaatggag tattacacat ttgtaataag tgttcgagat agcctttgag 210780
tcatacagta tttggaatgt atgcttggct gtcagtgatc ttataagacc caaaccacag 210840
ttttctttat gctgtgtcct ggcgctgcca atggccagct ggaagggcca tggcagggta 210900
gccacgtaga gaggccacct cctagaggcg catagcctga acgaaagcgg aatttgaaca 210960
acacctccga aaagattgga aagtcatggt atctgtgcga ttgcccacaa ggaggtctcc 211020
tgaagtcgaa gccctttggt tctctggcgt tttaatgatt tgctattctg tcatcggaaa 211080
tacgtggagc agccacatcc ttagacagaa gaggcccagc cacgttgctc tggagtagaa 211140
tttagtatga gtgtgagtgg aagttaaaca gatgtggaag cgcagagtgc agctgaacat 211200
cattgacatg gaccagcagg taaacagact tcaaggtgat acacccccgt aaggcaatgt 211260
tctggccagc tccgccagtc aaggctgtac agcggatagt aattatttct gtcacagcga 211320
agatagatgc tggatgtggg cagatggggg tagacttgtg aaaagtgtga gtatctttga 211380
gtatctttta taaatttagt gagtggagtg gcaacccacc tacacttcta atttttgctg 211440
ttggaagcta tgtccagaaa agagaagaga aatttctcta cctgataaat tacaccttat 211500
tcaaaacaca ctgtgtgaat gaaggtgctg cttcgtcttc tctctgctaa cgtaacgttg 211560
tgcacaatat tttttctttt gaagcagcag aaggacattt taatagaaaa atacctttac 211620
tcctgttaaa ggagtatctt ggagttcttc acctgtcttt atgggggaca ctccccacta 211680
catggcttca taaggattta gggatgactt gctcattaga catagagtga gctggttaga 211740
aagacaagtg tgagttgggg tacagtggca tagaatgttt aaaatattga gcaatttagg 211800
atccttattc tggactttaa ttgtttctag agccagcctc tccacgtgtg agtagcatct 211860
ttgagtggca agaaaaccat tctgggttgt cattgagagc atgtgtcctt ggagagtgcc 211920
ttagcagtac ctcctgtgtc ctcccacgac acatatccac ctatgcacac gtccaccatc 211980
ctatacgcac acaggtgcat cttgcagttt cacagcccga gcacagccag agagaaatga 212040
ctaacataga cttgattttt cgatttaaag acgctcctct ttttgctctt cctcttgaat 212100
atgacttttc ttttccttat tttcagtgtt ttcaagggaa atgtcaaatt ttcagacccg 212160
taacttctgc tagaatcaca gaccattagg gactgtagag atctaacatg cccagctgga 212220
agcgccacag caggatagct gtgtagagac gtgcagcagg cattcagaaa aacagatctg 212280
catcttggaa agagaggtca gggctcgact tgtggatttc agagtcactc acttagaagc 212340
agtagacata gtacacatct aatgaaagca ttcccctgct cggaaatctt cagaagtccc 212400
tcagatttta cagaatcaac tcaaattact cagcaagacc tttgacaccc tccaccatgt 212460
aacctcttct ttcctcctct cccacttctg tctccccaca cacatacacc tccaaccgca 212520
atggtctctt gaacatatta gcacacgttt cttcccactt tttctcaagc tgttttattt 212580
ctttagcatt agctcagatt ccacttcctt ctggaatctt tctttcatga attcagatcg 212640
tgaaagacca aagggaatgt tggggcctgt catgaattag aaaatatatt ctctgttttc 212700
accaatcaca agtcttgtat gacttgccta gaatagcttc ctttatgtgt tctaagggat 212760
atgggagccc gtctagactg gcctccttca cagcgctggg atccgttctg caaacccatc 212820
acagaaatac atgtggcttc ttcctgcagt aaaatatgta ggaacttatc caagattttt 212880
ctttttattc ttcatttatg ttattttatc tccagtgtta tgtctccaag gatgttaggt 212940
tgaattatcc cctctgaaaa gccatactag tttttgaatt aggatgcagt gattctaact 213000
tcaggtccac tgtcaactca ttagtttatt taggcaagtt gcataacctc tgccttaatt 213060
tatcatctgt aaaatggggc taggagtaac tcatgatttt tataaggaaa aataagacct 213120
gaagttaaaa cattttggaa aatgttttca aatatggaat acaaacatga ggtgatatta 213180
ttgctaccat attgcttata gtcaagaaaa aaacttaatc ctttttgata atctaataca 213240
gactgtgtca tactatatgt tgcaaaaaat gtatagaact tgacattcga agagatgagt 213300
attttggctc tgtggtttat tagctgtgtg tccatggctg acttacctaa cctttttgag 213360
cttcagtttc ttttctataa attgggaata attatgttac tatttattag ggttgttaag 213420
taattatatt ctgcaactat tatgcatgaa aggcactttt aaaactacag aagagcatag 213480
tcaacagtaa ccatcatggt ctcacttatg gcctaataat tatgcctact gtagaaatag 213540
atcaaaatgt atttggattc ccttttctag gataccctct cagattgtcc caaatataca 213600
agggatgaaa gaagaaggaa caagtgtggg ctgaatatgc agaagaggat ggaaagttga 213660
caggagcatg tggttggaag aggccatgtt gacatgcaga ttgtgtgata gccacattgc 213720
cagagctgag agggtgcagg agggaaggca agagggaagc cttggtatcc atgtaaaacc 213780
agtgaccact tgctagggtg tgtccataag cattgcatgc ctattctttt tttttttttt 213840
tttttgtatt ttatttattt attttacttt aagttctggg gtacatatgt agaacatgca 213900
ggtctgttgc ataggtatac atgtgttctg gtggtttgct gcacctatta acctgtcatc 213960
taggttccct cccctcccca ccccagtccc caacagaccc cggtgtgtgt tgttcccctt 214020
cctgtgtcca tgtgttctca tttttcaact cccacttatg agtgagaatg gcatgcctat 214080
tccttttttt tttttttttt ttttgagaca gagtttcgct cttgttgccc aggctggagt 214140
gcaatggtgc gatctcggct caccacaatc tttgctcctg agttcaagtt attctactgc 214200
ctgagcctcc tgagtagctg ggattacggg catgcacctc catgccctgc taattttgca 214260
tttttagtag agacggggtt tcaccatgtt ggtcaggctg gtctcgaact cccagcctca 214320
ggtgatccgc ccatctctgc ctcccaaagt gctgggatta caggcgtaag ccgctgcacc 214380
tggccagcat gcctattctt gaatgtgccc tttaagcagt agtggacaac ctggggcatc 214440
ggtggtatcc tctgtgggac aacagacacc tatatgggag ctggttccgc ttccctcact 214500
tatggctttt tacagccatg tgccgcataa cgacatttgg gtcaacagtg ggtcacatat 214560
atcatgatag tcccataaga ttataatgaa gctgaagaat ttttatcgcc tagtaatgtt 214620
gtagccattg taatgtccta gtgcaactca ttactcatat gtttgctgtg atgctgcaac 214680
cctactgtgc tgccagtcat gtaagagtag agcacatgca attcggtaca gcacataatg 214740
cttgataatg gtaataaaca actgttattg gtttatgcac ttactatact atacttttga 214800
tcattgtttt agactgtatt tcttctactt atttaaaaaa aaaaaagtta actgcaaacc 214860
aacttcaggc aggtccttcc atagatgtgt aagaagaagg cactgttgtc ataggagatg 214920
acaggtccat gtgtgttatt gccctgaaga cctctcagtg ggacaagatg tggaggtaga 214980
ggtgatatga atgatcctga ccctgtatag gcctagacta atgcgtgttt gtttcttagt 215040
attttatttt gtttgctatt tatgtattta tttatttatt gagacagcct tactttgtcg 215100
cccaggctgg agtgcagtgg tgcaatctct gctcactgca acctctgcct cctgggttca 215160
agccattctc ctgcctcagc ctcctgagta gctgggatta caggcatgca ccaccacgcc 215220
ggctaatttt tgtattttta gcagagacgg agttttactc tgttggtcag gctggtctca 215280
aactcctggc ctcaagcaat ccacccgcct cggcctccca aagtgctggg attacaggtg 215340
tgcaccactg ctcctgcctt agtattgttt taaaaaaaaa agtttaaaat tttttaaaaa 215400
tgaaaataga aaaatgttta ttgaataaag atataaaaga agaaaatatt ttcgtacaac 215460
tttaaagtgg atgatgtttt aagctaagta ttattacaag agtcgaaaag ttttaaataa 215520
tgtgtttata aagtaaaaaa gttacagtaa gctaagttta atttattatt gaagaaagaa 215580
atttcaaaaa taaatttggt gcagcctaag tgtatacagt gtttataaag tctgcagtag 215640
tgtacagtaa tgtcctaggc cttcacattc gctcaccacc cactcactga ctcacccaga 215700
gcaacttcca atcctgcaag ctccattcat gggaagtgcc ctatacaggt gtaccatatt 215760
ttatcttttc tgcttcattt tgactgtatc ttttctatat ttaggtatgt ttgaatgcac 215820
aaatacttac cattgtaata catttgcctg cagtattcag tacagtatca tgcagtgtag 215880
gtttgtagcc gggaagcaat acattgtacc atgtagccta gatgtgtagt aggctgtccc 215940
atctaggttt gtgtgagtag actctacgat gttcacacaa cagaatcacg tgaagatgca 216000
tttctcagag catagcccac cgctacccaa cacatgcctg taggtgagga tgaggaggta 216060
tctgtgttaa actgtgtccc ccaccaaaat gttgacaggc taaacctccc agtgtccatg 216120
aacaatggct ttatttggaa ggagattttg catatgacca agttcagatg aggttattag 216180
agtgggctct aatctgatat gactcatctc cttgtaaaaa ggggaaactt gggctcagag 216240
atagcctccc tctgaggcta ttaccgtgta aagactggag ttatgctgcc caaagccaag 216300
aaacaccaaa gatatccgga aagccaccag aagctgggag aggggcatgg aacagattct 216360
cctttgcacc tcctggaagg aaccagccct gcagacacct tgatctcgga tttctagcct 216420
ccaggactgt aagacaatgc atttctattg ttgaagcccc ccagtctgtg gtactgtgtt 216480
attgcaaccc caggaaacta acacaggcag gtagaccatc cacacacacc accgcttctc 216540
tctgacgcct ggtgcacagc ttgggtcttg tggtgagact ccacatggta ggcatttgct 216600
ggcggtggat gttaaaaatg acaagatttc ctctggtttg acttttgaaa gcaggtgcat 216660
tgaaagccaa atctcagggt ttggggttgg tttagaatgg gatttctgaa acattctaat 216720
tgtctcattg ccatcacctc cccaaatact gtatctttat gtgcatttgg aaggaaaagg 216780
agtgcaattg aacagtatat ttccgtctgt taggcaaaac cttttatttg cttcttattt 216840
ttccaggctt ggacactttc gtgagaatat ttgcagttct gttgtaagtc cacttcggtc 216900
agggatttgg caagtccaca acaaagagag ggaatgtttc ttttcccttt tcccactttc 216960
cttgggcttg cctgttcttt ctctgaaaga tgctagaact tccccaaggg gagggcctgc 217020
ctttttcctc cttgggaaat gttgatttat attatatgaa acatttgttt ttcatagaaa 217080
cttccatttc agcatgttga aatagttggt tctaattttt atgtgaaaaa taaataaact 217140
tgtcgtggca atactctcag ggtacagtta cataataact atgtatgcct ccccaccact 217200
cattaacata ggagatctca cctcacggaa gtcatctcat agtctaagct ttatggcttc 217260
taacagcttt tacgaaactc catgaaaata ccttaaacat aactgttaca agttgaaagt 217320
caaccctttt tataagtatg tcagaagtaa ttatatcttg tagtagcaat ttcatatctc 217380
tacttatagt tgggacaatt aaggctcaga aaaatggcaa agctgagatt aaaattcagg 217440
attttctgat ttctagccaa tgtcatgctc attttctgtg ttaattttat ggctcagggt 217500
ccagttaaaa acgtctgaag ggagtggtaa gtacaagaga gatgggagtt gggggtgggg 217560
cttgaaggag agcacacctg gccccaggtg acaagactgg gctccagccc tgcctcatca 217620
cagttggaca tgatggccct gggtcatttg acttttgagg acctcaggaa aatgagggag 217680
cttaaaaaat tctatggttc ctaatgaaat acttagggat gaaattacag ttctgggatt 217740
tgcttgaaga cacaatcagc catggtttgt cactgttgat gctgagtaat ggatatttgg 217800
tgttctattg tgagtctttg gtacatgttt ggaattttcc atgaaaaaac cttctgcttc 217860
taaaatgcac accttgattc ttcccatcgc cctcctactg gctggtcctg tgcagctcac 217920
tcatttctca ggaacagcag cagactcact actctgaagg aaagaaagcc ctttgctttg 217980
gtctgttcct aatgtacata ttattagaga cttttccgac accctcccca ttttttattt 218040
cttaacagct aatacgatag ctgtgctttc ataataaatt caaaagctgc tctctatttc 218100
tcaccagttt gaattgtaga aaagagtaca aaagattaga gtactttaaa ataaatctca 218160
gctaattata catacaactg cattcactaa atgtgaatat tttcaggctt tctttgctac 218220
caagtgccac ctgctcatga tttaaatggg cacaaattta gttccattaa acaaaatgca 218280
gcaactcttc tcctatagcg caaactcctt taggtcctat tttgaaactg agaagctaat 218340
tccagtgttc tcttgttagc tctcggtcca tgtcaaccac cccacaaggt tgtttacttg 218400
aatagtttgc agccttgctt taaaagttct agtaggcaaa taggtttgtt gatgatgaag 218460
tggtttgtgt tttataagag tccttatggt ctagatggca tttgaacttg tggttccagt 218520
gattaccagg accctgaatt gaagaataca tgctgtggcc ttttcagctc aggaaacttt 218580
ttactttcta ttgccaaaaa aaaaaaagac aagaaatcct tcctcaaaat gttatgtgtt 218640
cttagcccat acaactgtct ccccagaagt cactggactc aaacctccac tttgctactt 218700
gaacatatta aggtcattta aggagaattc attcatctcc tattaatctg gaacattcat 218760
gatcgctgta agaccaaaga ggacattttg gggggtaata agaaagttaa agctgccttc 218820
aaatcaaacg tgaattatga aactcttttc caagaagctt ctattagtgg cctcatcagc 218880
tatgtttcaa gaaaggaagt tgaaaaaaaa tcccacaaca tggaatgcgt atttgccatg 218940
ctcttagaaa aatggtttcc ttgcgaagac tcctttgtct ctacatacct ggacctgaag 219000
accttggtgt tgttttataa ccctggaagc ctggctgtga tcatctatta aggaaggaga 219060
aggaagctgc ttatctgtcc tgaaagtctt atttctactc atcttctcgc ctccttccac 219120
accacctccc cacctacaca cacccttgcc ctaaattcct ttccattttg tcctttcgaa 219180
aactcctccc tcccttagaa aagctaaaaa taatggtaat actttccagt gatcctccct 219240
tattaggatc tcagatgcaa gctgcaggca aggaggaaag cctgcatggt cgctgctgct 219300
cacatctgca tggttacaaa tcgtggctca ctccagctct catcttagat gttcatcctc 219360
acttgaatcc cagtgccata acacgccaac gcgcctggaa aacacctgct gtctataggt 219420
tgcaagcacc ccacagcatc ccagatgtag ggtcatagac tcagagaatt gaatacacac 219480
ccaaatcctc tagctgtcat tagggggagt ttcacatgat tgtagctaca cccaggattt 219540
taagccccca aaagttattt aggaaggatt gcaggctcat tcttgtgttc ttaggagggt 219600
cccgacctgc ggataaagac ctagaggaag ggggaggcct tgaggcggag tcccccaagc 219660
agagccccaa cttgtgtgtg atcctgcgcc acaacttggc cagccggcct ggacagctgg 219720
ctctggttac tgtgggaaca atgcaaggaa ggccgttgtc acattcctct gaggtcaaag 219780
gcacaacctt cgtcacacac tcagtccctg ctggcaaaga gaaagacgag gagcgtggaa 219840
tcggagacct ggagcatgcg agggacttga gaaattcacc aactcccttg ttttactgat 219900
taggaaactg aggtgcagag gagagctatg acttgctcag gatggcacac ccaggactgg 219960
aattttctct tcatggtcca ataccctgat gttcctctca tcatctccag tacttcagac 220020
ttgatagtaa aaaaggattc ttgataacat tattatattt tgttatgttt tcccatgctg 220080
caatcgagtc tttaggttcg aagtgacaac cctgttactt ttgttgcgag acccttgagt 220140
actcccagga caaatctagc caacaaatag catctttagt gaccctatgg gaagtcattg 220200
gcttctagcc ctaaacccag aggttagagt taatttttaa gtgctcgcct ttaactcaag 220260
catgaagctc taaaagcatc aagtagtaat gcttgaaaac atctaaattc ctctgagccc 220320
taggcatgct taaactctct ctctctcttt tttttttttt ttttttttag gaaaatagct 220380
gaaatggtag tggttagaac acatgcaaac agaattactg aataaaattg gtcacgtatc 220440
ccctggttta aggcatattt aggagttcaa ttcacatgta attgatcatt cttttttctc 220500
ttggcatact ttcctgtaag agtcttatgt gccctgcctt tagcatatgt gcaagccgat 220560
aaaggatgtt catttaaaat ttttactatt ttaaaaatac acacagaggg ggaaaagact 220620
tgtcttatcc ccaaatgaaa agaattagaa ataatacttt tgcctgtaaa cttctatcag 220680
ttttcctgtc atgggaaagg gaaccataaa ttacttttta taaggaaagt ggtggtgcta 220740
gggccacatg tcccctcccg cacagaatga gaggtggtgg tggctgcggg acggtgggaa 220800
ggaatgagcg ggacccaggc cagagctcag ctccctgggc tttgcttgtc tcgcattttg 220860
taaactcaaa tgtcccatca ttcccaaagg ccatttgtgg acatgctgtg attttatgca 220920
tcaccttctg gaaagaatgt gttccgttcc ctgtgaactt atccaggttg atacagtagt 220980
tccccccacc ccccatcttc ggtgtcattt tctgctgttt caattaccca cagtcaagcg 221040
tggtacaaaa acaggtgagt gccatgcaat aagatatttt gagagagaga gagagacacc 221100
acattcacat aacttttagt acagtataat gttatgattg ttctatttta ttattagttt 221160
ttgttgttaa tctcttactg tgacttattt ataaattaaa ctctatcatg ggtgtatatg 221220
tataggaaaa aacatagtag atatacataa aggtactatt catggtttta ggcgtccact 221280
ggggtcttgg aacagatcct ccatggatgg gaggacaact gtcttttgaa tgtgtcagac 221340
acaattgtgg catttcttag tgtctttttc ctactcgtta gttgtatttg gctgctgcaa 221400
acaccttggg ctcccaagta gttgggaatg tggaaagcta catactttcc ctctagagag 221460
agccccagtg tgaaaaacta agatagccgt gtgtttgctg atccttggga cgagccaggg 221520
aagggctccg ggagcactgt gtgaattaag gctgtcaaga ccaaagtaac ataggaggga 221580
gaagatgaaa atgcagcagc acgtctctta atgtgatcgt ttctctttcc ccttactgaa 221640
gcatagtgct ctctgctatt tgaagagcgc aatttagatt tatattaagg aatgaataaa 221700
taggatgcgg tgatgaaatc tcatctggag tgaatgcaga ttgtggatgc taatgaccgt 221760
gtggctgtgc agagaaccca ttggaagcct gggcgcttct ccctcctctg ttcacccact 221820
aggcactcaa gagcaactca ggcagtgggg aaaaggttat ctttttttaa tgtctctcag 221880
tgttgcatct tgccttatag cgccttaaag cacttgacaa gccttcaagt aattcttggt 221940
ggtggcgttt tcccccagaa ggccttaaga gatggtttta atagatacac ctatcaattt 222000
attcccaact tgagcatttt gctgtcttgc atcatttgac atcaccagaa agtcctttgg 222060
ttacttctgt agttcacatt gtactttctg tcctttgagt tttgggtgct caggggcaag 222120
atgtcagaaa tcctgagttt tagttgtgcc actgcgtagc tttgaccaag tcactttacg 222180
ttagcaggat acaatttccg tgttcattaa atgaggagac tggactgaaa gctcttagag 222240
gcctcctcta gctcagacgt tctgtaacac tcagggcttt ctgcctcctc tgatttggcg 222300
gtgtcaggat acaggtccaa gtgcggcact gtgccttgca aaattgctct ctctccctgg 222360
ccagcttttc caccactgtg gaatgaagtc tgccgcctgg aagaatccca gatttctcaa 222420
aggcgtccag ttctagggag cagcgtgcaa agcccttgag cacactttga cttcttctgc 222480
cctggctggt gatgaaaaac caggtcacca gaggttgccc tgtttccagt gatcagccct 222540
cgggactgaa aaaggaacaa atacagaaga gctccaaaga aagaaacaga aagagacgct 222600
caagctggga agctaagaac aggtccctct gctggggtgg aaggagaaag aatcttaatc 222660
ctctgccttc ccccatgggt cagagtcgta aatgggtgag acttgaaggt gtggttggtc 222720
accctctctc aaagtttcag ggctgggtca ggtgtcctag tagtgttgcg tggtgcagta 222780
gtgagtcccc agcctgcatt ctgcaaagcc ccagaggctc cccataaact ttgaggctgt 222840
gggctgccct cagcctctat tgaccggggc agcggggcag cttctccttc agctctgtga 222900
tattctgagg ctatgtaaaa tagttttctt agaaaggtcc tgtggttaaa aaaaattttt 222960
tttaaaccac tggtttagtt acgatgagct catattcaaa gcaatatgac cttagacaag 223020
tcatttgatt ttcccaaacc tcattttcct tatttcaaaa caagtttagt catatattct 223080
cagcctgtct cccacagcaa tttaaggatt aattagagtc agttattcat accttcactc 223140
tatgaacacg gtattgaaca cctttcagta gaaggctctg ttgggagagg aactcataag 223200
taaatacatg agacagccat tccaagcaga gggaaaaagc atgtgcaaat attttgtaaa 223260
ctgtaaaaca caacacaaac ctaacattat gtaatattgc tgttcttaac caggcagttt 223320
aatatagtga ctctagagcc taactccttg gctttgaatc ccaactgcag ccatttatca 223380
gtgtgacttc aggcacttta cctaccctct tgtgcctcag tactccaatc tgtacaatgg 223440
gaataataat agaactcatc tcactgggct gttgggagag ctgaatcagt tccgggcgca 223500
gtggctcatg cctgtaatcc cagcactctg ggaggctgag gtgggtggat cacctgaggt 223560
caggagttcg agaccatcct ggccaacatg gtgaaacccg tctctactaa aaatataaaa 223620
aattagccag gcgtggtggc acgcgcctgt agtcccagct acttgggagg ctgaggcagg 223680
ggaatcactt gaacccagga ggcggaggtt gcattgagcc gagatcatgc tactgcactc 223740
cagcctggtg acagaacaag attccgtctc caaaaataat tataataata attaagagac 223800
tgacacagag taagcactct ataatgttta ttattggtga tttcaccaat gcactgtgaa 223860
attctgtttc ttgattctca gcattgcagt cccctgtcat tgcacttcca gttttctctt 223920
ccccagaaga tgcatcccgt gttcgagcgg aaaggcaagg gaaacatcat gtcaagaaaa 223980
gagttccgaa cagtactctg tttctgtggc atggatcctc tttcctctcc ttttctcctt 224040
tttttgaggt tggattggca ctcctctcag acttaaacaa aggctttgct ttgcagagag 224100
gatctttctg ccttcggtgt gtcatctgcc tctaagggtg taatttgttt ctgatgcatg 224160
cagggtgccc ccttgagaag gctttgttga tgttgtgcag aggtgtcctg tattgatcgg 224220
tgatagaact gttctatagt gggtgaatga ggtaattgtc atcaggttac tctagtcggt 224280
gaccttgagg ctgatccgat gactaagcca cagaggtgga tccctggtta tagaatgtcc 224340
ttgtttaaag gtaaatcggt gtgagagtga ctaatagttt taaagaaatg atggcaagca 224400
aatggcatgc cctttggtga gagacacagt ctatatcaat aagctctgag gccacccata 224460
tctgggtgag atattggggc tgattttcaa gggttccttt atctctctgc tcctctctta 224520
tctcttttca ttagattcca attctccata acttccatga ccgtgtataa tacagtcact 224580
gccatgactg tgtataatat cgtcagtgtg aagttcagag caaaatacat aggcctctga 224640
gctagttggc tgggtttctt ttttcttttt taaaaaattc agcagtgggg tgggacagag 224700
ctgaagatga aaagatgctt gatacaagag aagagagaaa gcaagcgtca tgataaaatc 224760
tgcatgcaaa aaaacccttg ttataaaatg aaaagtggaa tgaatcatta gctatacatt 224820
taagctggat caacacatta gccctgtgat taagagtttc taaaacctac ctgccagcat 224880
ccctgctgtt gctgaactgg tcctttctgc atgggaatgg gtagaagtct aaatgaacag 224940
acttagagtg ggttggcagg tgaaggatag tgggggtaag tagtgaggag aggataggtt 225000
agaatagtta ttttgggctg ggcgcagtga ctcatgcctg taatcccagc actttgggag 225060
gccgaggcag gtggatcacc tgaggtcagg agttcgagac catcctggac aacatggtga 225120
aaccctgtct ctactgaaaa aacaagaatt agccaggtgt ggtggctcat gcctgtagtc 225180
ccagctactt gggaggctga ggcgagagga ttgcttgaac ctgggaggcg taggttgcag 225240
tgagccgaga tagtgccatt gcactccatc ctgggtgaca gagcgagact atctcaatcg 225300
caaggacaaa aaaccaaaca ccccatgttc tcactcatag gtgggaattg aacaatgaga 225360
acacatggac acaggaaggg gaacatcaca caccggggcc tgttgtgggg tggggggagg 225420
ggggaaggat agcattagga gatataccta atgttaaatg acaagttaat gggtgcagca 225480
cgccaacctg gcacatctat acatatgtaa caaacctgca tgttgtgcac atgtacccta 225540
aaacttaaag tataattaaa aacaaaaaaa agattaaaaa aataaaaaga acaattattt 225600
tggaatcatt gaataacagt cagctctttg tatgttggtc aataaaagca aacacctata 225660
atactgctct aagtgctttg tgctatatta accctttaat cctcacaact tttgttatgt 225720
aaattttata tctgaaaaca gtgaggttaa gtgatttgcc caaggtcatt taaacccaga 225780
tattggctct gccccggtgc ccttaacact tatagcctct cactgtcctg ggtggtgaag 225840
gtcttgaggg caaagagaga aaggaaattc ctattttcag tggacatatt tcttgtgccg 225900
gtggaaggaa tttaattatt acaaggggtt tcatcaagtg cactaatctg ggaagttgcc 225960
agcaagctga cctgggttta agtgattctc ctgctttgac ctcccaagta gctgagatta 226020
caggcatctg ccaccatgcc tggctaattt ttgtattttt agtagagatg gggtatcacc 226080
atgatggcca ggctggtctc aaactcctga cctcaggtga tccgcccacc ttggcctccc 226140
aaagtgctgg tattacaggt gtgagccacc gcacctggcc aagacacctt ttttagcttc 226200
caaatcgaag tctgtttttg cctgtatcat ggttgtattt cagttagaac atcatttctt 226260
tttttttttc tttttttctt tttttctttt ttttgagaca gagtttcact cttgttgccc 226320
agactggagt gcagtggtgc agtctcggct cactgcaacc tctacctcct gggttcaagc 226380
gattctcctg ccccagcctg ccgactagca gggattacag gcacctgcca ccacgtccag 226440
ctaattttgc gtctttttag tagtgacagt gtttcactgt gctgaccaag cccatcttga 226500
actcttgacc tcaggtgatc catctgcccc agcctcccaa agtgctggga ttacatgcgt 226560
gagccaccgc gcccggccag aacatcccaa tacataggca gccacttatg cactagagtc 226620
cttctcggag ggtgagcaga gttggctctc cctgtcggtg gcatcacgtt ggcagaatac 226680
acacactttt atcctgtggc ggttggcgag gccattgatt tgctgcgtag aatagcaagg 226740
aaatactcta gacaggttta acatttgtta ttgctaatga atttgtcaag catcggaatt 226800
cagggacggt tgatgcacac ttaaaatgct ctgaaataga ttttaccttt tataaaagat 226860
aataataatc tcatgtttga atcacaagag gtacgttttc cttaaatctt ttaattaact 226920
cctatttcaa gaaaaacctc ttatcaaaaa aaaaaaaaag attttacatt tcctaaggcc 226980
aagtaagagt tgaaggtaga atgagtaaat aaccaagttt atggaaattg taaaataaat 227040
acatgtgtta taaatgtgct atttaatgaa aatgtgtatt gactagagca ataatgatgt 227100
atctttgacc atgataagta ccagtgctga aatccatcca agccacaaaa atgattggag 227160
ggtccatgtg gaatataaag ctctgcagag tctagagctc atatcctata tggctttttg 227220
ctaattaata aacattggcc ttttgtctat tatttaatag cctaattgca ttgcacattg 227280
cagtagcaca ttgcaatagc acattggcaa aagtgctgcc tttcactgct aaggggggca 227340
gttttctgta aaagaggtta aaaggagaaa tcagaagcct aatttttgtt aaatgagatg 227400
tcccccaaaa gtcagataca tgcatatttg ggctaaataa atctttcctg ggaaactctt 227460
ctatgactgg gcagagttgt tcacgagaga ctttcccccc aacattttat taggaaaaat 227520
tgcaaacata caagtaaatt gtaagaattg tacagtgaac acccataaac ttgccaccta 227580
gattttgcaa ataatatttt gctatatttg ctttgtcagg tatcaagcca tctgtccatc 227640
ctgcagtcca tcatgtttta gttgatgccc ttcaagacta gttattgtgt atcattactc 227700
aatcaaaata aaatattggc tttagttctt gcttttaggt aaattttatt ttattttatt 227760
attactatta ttattattat tgttgagaca gggtctcact ctgtcgccca ggttggagtg 227820
cagtggtacg atctcagctc actgcagact ggaccttcgg ggcttaagca atcctcccat 227880
cttagccccc tgagtagctg ggactacagg cataggctac cacatccagc taatttggtt 227940
tttggttttt ggtttttttt tggtagagtc agggttttgc caggctggtg tcaaacttct 228000
gggctcaagt gatccaccct ctttggcccc acaaagtgct gggattacag gcgtgagcca 228060
accatgcctg gccagaaaaa cccaaattga gggacagtcc acaaaatgat tagtctgtac 228120
tccttaaaat tggcagattg tcacttttat cacatcatat gtgacctatc atgggctgtt 228180
gatcttgatg acctcagccg aggttgtgtc agggtttgtc aactttaaag ttactctttg 228240
tacacagaca cactcacaca cacccttttc catactgtac tactcgttgg aaggaagtca 228300
ctgtgcacag cccacactta aggggtgggc agttacgctc tacctttaca agggcagaac 228360
atctgcatga attatttaga actcctttgc tcaagagatg cgtgttttct tcctctttta 228420
aaatttattt atatcaatat gaactcatgg gtgtttattt tattctttag gttctaatcc 228480
agtactatgt tgtttatttt gttgctctgg ttgttttagt tctggccatt ggcagctctt 228540
tgagaaatat taggaatatt gtctcttgtc ccccttttat atgcccccat cactgtgggg 228600
tattgattta tctatttagc attttcccac tttctgatac tacaagatgc tccatgctca 228660
tcttggatat tccctgtcac agtactagaa tcagccattt ctccaaagac ccctggtttg 228720
ttttattgga gaatggtgtt aggaactaag ttctgggtgc tggggcttgc agaaatttta 228780
tgcccaacac atattagctc cccctcttcc ttttgtggga gtttggtgtg tgcagtagtg 228840
agtgccctgt gaaatcttca tgctacagat tgactttagt ccctcactga tcctagttca 228900
cttcaggagg agcctagctc actgtggcag actagacaga aggcagccca gccagtcaac 228960
tcaacagatt tcatttattc agctcaatcc aagtcagact tggtgctgtg cttattcctg 229020
tgggcagatg ccctgccctc acagacccct gccctctaga atcaaatgac aggacagtaa 229080
cagagaagtg ctgtagaaaa tcagaataca gaagggctgg tgcgacctag cctaagagca 229140
ttcaaagaaa gctgtttata caagagcaga cttaggaagg tttattccag atgaggaggc 229200
tagaagcaaa gacatggaag tgggaacaga tagtctctta aatatctatg gataagaaga 229260
aagccgaaaa taatgaagga ctttgcttct tgggtttatt ttaggtagga agtagggttt 229320
actgatcttg gtgggatgag gaaatggacc agtggtgtag tggagccagc ttgcactttt 229380
atgagccaag tgttaaatgt tcagaaattt ggggagcatg ttgacatcat gttattacct 229440
tgaaattggc catggtggga gtgtttacac tacagaagtc tgcaaatgct acacatcagg 229500
ggtcctctct cccctcccac ttttattaaa catttctgca cacaccactg gcttcagctg 229560
tctaaatatc tagtatgtac ccttaccctg aatttatttt tttttcctct agtagtcttt 229620
ttcaggtaca catttttatt tggtgctttg aattctctaa caaaactgtc aaaaaatggt 229680
tacagtagag atgtgtgccc ctgattgaaa actgcatttt actgcatatt ggttaaaact 229740
cttaacggtc agaaaatttt ttggttaact gggttatttg ggaccctcta atggccattc 229800
tcaataactg agttggaaaa gtgcatgatt caaatgtact aaaccattac ccagccttct 229860
actttatttt ggcagcatgg ggaaacctgt tgtcacctga aggtagtcat cagtgtcata 229920
tatatgtggt cataggattt atggttgggc tggcttggag gtatcttctg attcttacca 229980
agaatatagg aaaaaacgat atcattttct ttcagctgag aaaccatgac tcaacgttat 230040
tctgcttgta gtaggcaatg caaccctgta tcagtttgac ttttgcaagg atgatacctg 230100
agtaatccag ggaatagtgc tatgcaaata gggacagttt ccatgaagtc acctcttgtg 230160
catggtatat ggtgttaagt gttatgccga attagactca gagcagctta catttcaaac 230220
gagtcaccta aaagcagtta tatgcgtgac gaaggagaat ggttagggaa agaagaagac 230280
ttctcttact cataactgga gattgtgagt tttcactgtg atcctgaaag ataggttggc 230340
tttgccttaa ttacagggat ttcttttacc tctttgccct ttcctatgtc cctccatcag 230400
gtatggtaaa ttttcctagc ttttgttcct attagtgact ttactcctga tccactgcca 230460
aattgggtct ctgaggttgt aaaactcaga aaaggatatt gcaagcattc tggccatatt 230520
acaaatctca tgtgagagct cactctgaat caaaggagct ctcacattct tttttagtcc 230580
aagtgattcc tagatgtgga agccgatttc ctggaacact caaacgaggt cacagttcat 230640
cagctgcctc ccataaacca accctctcaa gtttcaactc tcatttgaaa cttcttggga 230700
tatcttgatc caaacagatc acctgaaaag ctcccttata aggtcaagtg atcacagggg 230760
tcttcttctt cttcttcttt ttattgtgat aaaattcatc atttttccca tttttaagtg 230820
tacagttcag tggcattaag tacattcaca ttatattgca gtcatcacca cgatccatct 230880
tcagaacgtt ttcatcttcc caaagcaaaa ctgcatatcc atgttgtagc atgtgtcaga 230940
atctccttcc tctttagggc tgaataatat tgcacatatg tatcacattt tgtatctatt 231000
catccattga tggacactta ggttgcttcc actttaggtt attgtgaatt atgtggctat 231060
gaacactggt atacaaatat ctgttcaagt gcctcctttc agtttttttg ggtatatacc 231120
tagaagtgga attggtgaat catgtagtat tttttaaatt ttttgaggaa ccatcatggt 231180
atttttcaca gcagctgtac cattttgcat ttctatcagt aatgtacaca gagttccaat 231240
ttgtccacat ccttgccaac atttgttatt ttcttgtttt gggggttgtt ttttttgttg 231300
ttaatcagag ccatcttaat gtgagtgaaa tggtatgtca ttgtggtttt gatttgcatt 231360
ttcctaatga ttagtgatgt tgagtgtctt ttcgtgtgct taatggtcat ttgcatattt 231420
tctttgaaga aatgtcaatt caagtccttt gcccattttt taatcaaggt atttgttttt 231480
tgttgttgct caagagtctt cttgcatgcc tagatagtac actacttcaa gaggctattt 231540
agcatttatc tggggttcca tggggcagcc tgttcccttt gcacatatgt aatgcagaga 231600
tgaatatgta gagacttacc actggaaaac tgcacctgga attctcagat ttgcccatat 231660
ctgcttatca tggacgaggt tcagtggtgg atgctgcaga atataccacc gactgctttt 231720
ggctactgtg tgacattgtc atctaacttt tcactaagaa aaataatctc tttagaggaa 231780
aggaaggaag ttgagagtcc atcttataat ttttcagtgt aataatattc tagaccaggt 231840
attgacaaac tggaccatgg gccaaatatc accccagcct gtttctgtaa attaagtttt 231900
attggaacac cgacatgcct gtttgtatga gtatcttcaa ttgctgcttt tgcacgacaa 231960
tgacagattg agtagttgca atggagatgt ctggcccaca cagcctaaag catttgctcc 232020
ctggtccttt atagaaaaag tttgccaacc tttggctgtt ctaggtgttt aagaaatact 232080
atttttagaa ccgtatatat aatgtagtga tgttgactgc aagctattca ctttgaaaac 232140
aataaagctt atgtagtaga tattactgtt ttaagtattt actgaataag atagacccct 232200
gttacattac tgcttttaag tatttactga attccaattt tgtgtccaga gctgtgttct 232260
ttgcctttgt tttttgattg gggcaatggc tttcatgtcc ttagcaccac tggggctgtt 232320
accagatgtg accaaaaggt ttctaacatg ggtagcactt tttttttttt tttttttgag 232380
acacagtttc gctcttgttt cccaggctgg agtgcaatgg catgatctcg gctcactgca 232440
acctccacat cccaggttca agcaattctc ctgcctcagc ctcctgagta gctgagatta 232500
caggtgtctg ccaccacgcc cagctcattt ttgtatattt agtagagaca gggtttcgcc 232560
atgttggcca ggctggtctt gaacttctga cctcaggtga tccactggcc tcggcctccc 232620
aaagtgttag gattacaggt gtgagccact gcgtcctgcc tgggttgcac tttttaaagt 232680
cacagaatct gaattctgcc tttcctctgt gatatttcct attcgtacta aactttggtg 232740
aagtagctct gatctttagc tgtggtgaga ggagttatgg aagagggacc tgccccgaaa 232800
cgtagaccac aggcaacttg ctgcctggca ccctaaagat ggtttcctgc ttctcttccc 232860
ctctatctcc aggtcagaga tgcagctttg ctaaggcagt gattgccaat ttgggaattt 232920
tgagatactg tggatgtgct gattgttttg tacaaattct cttcaatacc ttgaccatgt 232980
atacagtaaa cttatgctag ctgttagagg acttattaag gtgtatggac actgtctttg 233040
aagagtttat atggtatgtt ttggcagttg aagagtatta agcattgact taaaaaatta 233100
tgtataataa gcattgagat aatgggaaag aaatgctaca catacacaca cacgcatacc 233160
cacccgtgaa cacagacacc caggaaatca taaaacctga ttgacttcta tgtgtggatg 233220
ttttcttttt ttattcattt aacttatatt ttaagttcag atgtacgtgt gcaggttcgt 233280
tatataggta aacttgtgtc atgggggttt gttttacaga ttattttgtc accaggtact 233340
aagcctagta accattagtt atttttcccg atcttctttg tcctcccacc tccaccctcc 233400
agtagattcc agtgtagatg ttctcttaag taaaacgatg gggtagtcgt tttgtacagt 233460
ccaaataaga ttccgacaat ggatgaatct gctaagaggt taccttttgc tccagataca 233520
atatttatct aaaaggaaaa tgaaccctta acccttccat ggaatcgtac tgcttcacta 233580
actttttgag tgaagtgatg ggcattgata cagtattgaa aactttcagg cccttttctt 233640
tactttttga caatttgacc ttttttcacc cctgaaatat agcaatcagt atttctcttc 233700
tggatctggt tctacaacct acgttgattt taattacttt ccttgaaaac cattctcaaa 233760
atactctctg ccccttacat tttaagcttt aatgttgaaa atagagcttt ggtaagagtc 233820
tccttgaaaa tgattttctt cagccaatat cagaggagta tttccttatt tttatattta 233880
tatgttttaa ttccttaaga acagatatct accaaatttc atggtataga tttataatca 233940
tcttttcaat tttagacaaa ttttggaatt cagatgttgc tctttgaaat gctggtgact 234000
tctccaactt ggggacattc acggactcaa taagcatgcc ttttatttat gattctctga 234060
ggattcattc atttctgcat attttgaatg tctgctacac agagataaat gatgtaaaat 234120
ccaggctatc agagctgggt cacaatttag tggagaagat gagtacgaca aaaatttacc 234180
atggagtgtg aaaagtgctc ctcatagaga catgtacatc atgccatagt aagtttaggg 234240
aatttggaaa ctcacttaag tcctaactca atttaaattg tgttagactg tggataaatt 234300
tatccgacga gaaacacata ataatatgta tctactctga ggtaataaat gaaaaaagtt 234360
ggataaaata aaatacatct gttataacca atggccccca gcaaggccag tgctcttgag 234420
ccattattat tcctgcacat tctttgtgtt tgggttatta acattgcgct taggtcagat 234480
gagcgggtgt tcaatctgcc acactttgat aactaaagta aaatgctgat ggagatcatt 234540
taagactgtc tctatgctgt tgattgcatg cttgtggctc ataatcagaa tgatgcaaag 234600
taattgttag actgacttgc caaggctaca ttttgtgtcg ttgccactgt cagcactttg 234660
gtcccgctgt gctgcctgaa gaacgcttgc ctggcacctg ttgggcacta atacacaact 234720
ttccactgaa tgtcatgggt aacttttgtt ctcatatcct cgcttgctat cttcacaaaa 234780
aaaaaaaaaa aacaaaaaac cctgacaaag attttttttt ttttgacaga gtcttgatgt 234840
gttgtccagg ctggagtgca gtggcacagt ctcagcttac tgcaacctcc acctcccagg 234900
tttaagcaat tctcctgcct cagcctccca agtagctggg attacaggca cacaccgcca 234960
tgcccagcta atttctgtat ttttagtaga gatggggttt caccatgttg cccaggctgg 235020
tctcgaactc ctgacctcag gtgatccacc tccctcggct tcccaaagtg ctgagattac 235080
aggtgtgagc cactgtgccc ggctgcaagt gcttattttt tgtttgtcag aatgcttatg 235140
tattgagact ttaatctctc gtgcatgttg ccagggagct catcttttct ctttgaccgt 235200
gaaacccaga caaacctagc tttgtcactt actggtgacc ttggttaggt tacttttctt 235260
gagccttatt ttcctcatct gtacaatgag gccaataaaa cctattttac agagattttg 235320
tcaggattaa agataataga taaaaatgtg tccatacaaa ttagccactc agcaaatggt 235380
tgtggcaaat attaaggaat ttaatactta ctcaggatga tacaatacaa cgacaagaca 235440
acatttccaa aagttagtcc gaaaatataa tgataacgta actgtggaac atgtagtatc 235500
agcacggttt tactgggcaa gtcatgttta ccagagacac acaattggat ttggatgtta 235560
aaatctaaac cgcatggttt tatggctaga tctggaatac atgatatgtt atgggccctc 235620
ccatgtatac cttcagagga tatggagcta cctttggaag caatgtatga tttagtgttt 235680
ttcttttttt tttttttttt gagagggagt ctcactctgt tgcccaggtt ggagtgcagt 235740
ggtgcgatct cagctatctg caacctccac ctcccgggtt aaagagattc tgctgcctca 235800
gcctcccgag tagctgggat tacaggcgtg caccaggaca cctggctaat ttttgtattt 235860
ttagtagaga cggggttttg ccatgttgcc caggcttgtc ttgaactcct gacctcaagt 235920
gatcttcctg ccttggcctc cgaaagtgct gggattacag gcatgagcca cagcacccag 235980
cagatttagt cttgatggtg taaaaaagcc attgtatagc acacaacaca gcctgaccat 236040
ctaatgctca ctcatgtaaa agcggtgacc acgagagagt tgggcaaagc aaaaactctg 236100
tccctataag aagtgcattg ttagatctgg aaacatctca ccaggtcctg aattgtacta 236160
tgaaaagaga tttgttaaaa gtagctcagt tcatattcca tgatattgca aatgcctaga 236220
gtgaattgtc aaagaaatgc tctctctgac tccatccact gctgacattt aaggtctgtg 236280
ttcttagttc ccaacattga ttctatttca catggtcaaa atgtaataga catgtttttt 236340
ctaagagcat gacccccacc acaaattacc actcccctta aaaattgcat cggctggacc 236400
agggatgaag catttaggga gcatttgttg taagggactg tcacctgcca ttggttatgg 236460
accttggttt cacagatcag actctgtgtt gctctacttt gcatctccgc ctttgatctc 236520
gctgggattt tgcagccagt atctatctcc tttggcattt ctttgctgct gctatgtgtt 236580
ctttctccct ctgctgctct ctgccagccc catctcctgc ctgattcatg gagcagtgtt 236640
ggatacttag aaaaggttaa ctgcattcgt gtctccatgg ctggagacac gatttccaca 236700
cactctgccc attgcgggga tatgctcact tccccagcct cccctcaaaa gtgagatttt 236760
cctggaatgt cactagtcgc ggggggaggt atggcaccct taattgaggg caaggatgtg 236820
tcatgtgact tcagcaaatc ctatcacata tatttttacc aaaccaacca ttctctttga 236880
gaaggaactt agattagaaa tattaacact gaatgaatat tttaattttt gataccttct 236940
aaagaaatat ggtaagtcct gatttttttt tttttttttt aggttttcac cttcaaatag 237000
tgatttaatt tctaggatca ctcaagatca tacagttttt tcagttaact ttcctctgta 237060
tcattaagta actctaccat gattgggctg aaacaaggac atttgcttga cttcagactt 237120
agcgatttaa tacttgatct agccatccct attcacccat tatcccgagt ctttaaaatt 237180
gagtcctttt tcgatatgtt gaacacccac tgaatattct tttttttttt tttttgagat 237240
gaagttttgc tcttgttgcc caggctggag tgcagtggtg cattctcgac tcactgcagc 237300
ttccacctcc cgggttcaag tgatcctcct gcctcagcct cccgagtagc tgggattaca 237360
ggcacctgcc accaagccca gctaattttt gtatttttag tagagacagg gtttcaccat 237420
tttggccagg ctggtcttga cctcctgacc tcaggtaatc cacccgcctt ggcctcccaa 237480
agtgctggga ttacaggcgt gagccaccgc gtccggccac ctactgaata ttctaatgtg 237540
tgattctatt ccctgtggta tatgtgttag tttgtgttct tctatgctac acccactcaa 237600
accaaaacaa ctttttgctg ttaaggcttt ttatatttat tcagcctgcc tttctcaatc 237660
ttgaaaaatg tagaagaaaa agaaccacat gctaccacaa tatgtagtca cttcttataa 237720
acttgggaca ctttggtaga ctctgtaaat tcaacaaata aatatgtatt ggttcattcc 237780
ttcaatgtaa tactctttca gtcctcaaat gttatgatgt tgatacatct attgatgtta 237840
aaggaggttt tcaatataat taataagtaa aaaaaatgag acagcaaaat actatgaata 237900
ctatcatagt acattataaa tagattgtat gtatgtatat atatatatat atatatatag 237960
atttatttct atatgtatgt gtacaatata ctctgtatac ttgggcatag gagagagtct 238020
ggggtcatat aaccagactg ttaatagtga ttattagtgg gacttctgtg gatttgtatt 238080
acttgggttt ttctatttat ctaattatta tacagtgaac agttttattt tgttctcatt 238140
tgtctcatcc actttttttg actgcatagt cctgtaattt ttttttaatt tttaattttt 238200
ttgtgggtac ataggtgtgt atatgtatgg ggtacatgag atgttttgat acagacatgt 238260
aaaataaaca catcatgaag aatggggtat ccatccactc aagcatttat ccattacaac 238320
aaacactcca gttatactct ttattttaaa atgtacagtt attattgact atagtcactc 238380
tgttgtgcta tcaaatagta gatcttattt attctaacta ctttttttgt acccattaac 238440
catccccacc tcccctccag ccccctacta cccttcccag cctttggtag ccatcctcct 238500
actctctgtg tccatgagtt cagtaggttt gatttttgaa tcccacagat aagtgagaac 238560
atgctaagtt tgtctttctg tgcctggctt ttttcactta acataatgat ctctcgttcc 238620
atccatgttg ttgcaaatga ctggatctca ttctttttta tggctgaata atattccatt 238680
gtgtgtatat actatacttt ctttatccat tcatctgttg gtagacattt agattgcttc 238740
caaatcttag ctattgtaaa cagtgctgta acaaacagag gaagtgcaga tttttcctca 238800
atatactgat ttcctttctt ttgagtatat acccagtcgt gggatttctg gatcatatgg 238860
caacttgtct catttacttg tgaggggtga ggaaaaaggg aatacagtac aggtactcac 238920
attctggtaa tttttgttgt tgttgttgtt gtttttgttt tgctcttgtt gcccaggctg 238980
gagtacagtg gcatgatctt ggctcactgc aacttctgcc tcccgagttc aagcaatttt 239040
cctgcctcag cttcccaaat agctgggatt acaggtgcat gccaccatgc ccggctaatt 239100
ttgtattttt agtagagatg gggttttacc atggtggcca ggctggtctt gaactcctga 239160
cttcaggtga tccacctggc ttggcctccc aaagtgctgg gattatagga gtgagccacc 239220
acgcccagtc acattctggc aaattattaa gtcaccaaag tctctcctgt gtctttcctc 239280
cattgttaca gatatatgaa catgttgtgt gccaaatggt gataatgcct ttttgtttta 239340
ttcagtctct tctgtgtacc aagcgccaca ctaaaaacta gaaacattct atgaagtcga 239400
tattgttatt gccattatac aaatgaggaa agggttcaga gagtttaagt aactggaacc 239460
acacagctcc tctgtgactc agctgaggct cagactgagg tctgactttg aaatcagttt 239520
tcgtggtctc aagaattcgt actgtagacg tctcgtctgt tgttaggatg aaaaggtcaa 239580
tgcgtgtgag tggattataa agtgttgctt taaaacgaag aagatactca gagattttgc 239640
cagtatctac catttttcaa tgtttgcatg gctttctggc agtttttttc aattggagca 239700
taacctttgt ctttgcagcc ccacctagcc taggatagtc tgactgcata gtaagtgtca 239760
tgttaaacac ttgtgggctg ctctgtggga cttggaggag tgcccttcag attctgagga 239820
actgagtctg ggaatcttcc tgcaggctgg tgggccatcc tgaaaaagct ctatcctgcc 239880
ctggtggccg gccacatgcc gtccacgtcc tctgatgaaa agggcgggaa agctgtggcc 239940
ttccacagct catagaatga atcccaaaga tgctggaatc ctgggaaact tgcccacaga 240000
acatcaggag ctggaatagc tttgcctcac agcctctctt aaacctgcaa aggcgtcttt 240060
aaaatagtct ctggagatta ttgttgagtt ggatcttgaa cttagttcct tgtgtggtgt 240120
agattaaata gtctgttgcc gtcgctccct tatctccctt tctttcaggc ttcctctgtc 240180
caacattcac atcatctctg ttctttccca cactttgttt ggcccgtcag tatctcagac 240240
actgtggctt cctcacggga ttactcagtc agcctgatat gtggcctcca gcgcccctct 240300
gccaagtcca cattcccata tgagcctaat tacatacaga tcactgcagg gagtgaagct 240360
gtgggtatac cattttggga aagagcaaag tgcaggaatg gggtactttg gttatttatt 240420
aagacttctt cacagcctgg caatgtagca aaactccatc tccgcaaata aagaaaaaac 240480
acaacatttt aatccaggtg tggtggcaca tgcctgtagt cccagctact tggcggctaa 240540
ggcaggagtt tgagtctagg agttggaggc tgcagtgagc tatgatggca tccccatcca 240600
cggtcactga attcccccat gagagggact ttggagggag gatcccaggg tctgagctca 240660
gctctgccac tcacagccat gtgcacgtga gcaagtggct cagtcccctg ggcctcaggg 240720
tttccagcta taaaatgggc acggatctat gacaaacccg ggtaacaaag caagacccta 240780
tctcaaaaaa ataaaacacg gctgggtacg atggctcaaa cctgtaatcc caacactttg 240840
ggaggctgag gtggaaggag cgcttgaggc caggagttca agaccagcct gggcaacata 240900
gtgagacccc atctctacag aaacattact tcaaaaaaat acaaaaaaag acttcttcaa 240960
taagcatcat ggtgggcatg gaggacatga cattttaaga aaggcaccta aaaaattgat 241020
ttcttgggca ccacaatatg gactccttgt cacaaggacc atacatctca tgataaatga 241080
atcatgcctg tgattgttct ctacatattg attgttcaaa gctctgcttt taaaattcat 241140
atagtcagcc aaataatcac gcatctattg ttcttcagac atttattgtg cacctaataa 241200
aggccaaagt gctaggggct ggaatttctt atcacctcta ggcctgctca tttggactga 241260
tttagagaat ggagttatta atttttttaa aaaatctttt tttctattcc agttttccaa 241320
agaaattaga ccattttctt cgtgagaaag aaatcgacgt gctgttttca tagggtgagt 241380
gatcctttga atctttcatg tatttttacc cacatcaaaa tattatccaa ttactatgat 241440
gcaccaagaa aaagtgtgtg acagcatgca ctctctagtt ttctcctgct tggaaccaag 241500
gtatttttcc tattctttga ctctcctcat cactgggtcc tttggagagg atggtttccc 241560
ttgtagattt ttctgcgatt tcttttttgc cgttcacatg ctttgcctcg tgcgaggtca 241620
tcattgttgc tattaccttg tccagctcac agaaaggaag tttctttccc tcagcaactg 241680
gtgcacagag atacagctgt aggcaagggg gaaccatcca gtttcaagtg actgtgatgt 241740
cttttgaatt ccatgaccaa gaataacagg atatgagcac cagatgagac ctgagagctt 241800
gtctggcaaa ggccctatgt acagatgggg catctgaggc ccagaggctc acatcacctt 241860
tatggggctt catggagagt agcagagcta ggattttgat actggtgtgt ttggctccta 241920
gctgcatgat gtttgccctg cacaagtctg gttttggaat ctgcagattc tttttgaggc 241980
tgtagagtta taggtagttt aacttaatgt ggtcttggta atctaataat gatcacccct 242040
aaggcaaggg tcaagactga tactgataga ctatttgact ttctcataat cctagttggc 242100
tactaagtaa aggggttggc agagtgagtg cacccagaac acttctgtta tggatgtcat 242160
ctgagaaagc ttattttctt ctgcgccctt tccaaaccac tgcatctgca atgccacgtt 242220
gtcatgtgct gagacttggt ggtacatctg ctttgcagct agaagtcatg gtacacctgc 242280
aggtgtgtgc agtccagctg cagacccaca cacccgactc gcggttgtct gcacctgcag 242340
aagaatggct aacagggttc ctatattgaa gtacaaatct gaccttcata gagacttttg 242400
agaaacattt attcttttat tttatttgtt tatttattta ctttgagacg gatctccctc 242460
tgtcgcccag gctggagtgc agtggcacga tctcggctca ctgcaagctc cgcctcccgg 242520
gttcacgcca ttctcctgcc tcagcctcct gagtagctgg gactacaggt gcctgccacc 242580
atgcctggct aattttttgt atttttagta gagatgggtt tcactgtgtt accaaggatg 242640
gtctccatct cctgacctcg tgatccgcct cggcctccca aagtgctggg attacaggcg 242700
tgagccaccg cgcccggccc catttattcg ttttttttaa agttatgttg gtttttacat 242760
aagagtgcag ttgtgcaata agatggagag aagttaagaa tatgattctc agttagaatc 242820
ccagaaggta aacttgactg tgtgtgtggt ttgtttgttt gtttgtttgt ttttttagac 242880
atcctaggtt aaatctggct tcaaattgtg ttcatttagg ttggtgaact aagtgcactt 242940
atttccaaaa catttcatct cacctaggga gtggtcaaag ggtagtatta agagcttgtg 243000
tttattattt tatccaactt gtcagcttaa tcactttgtc ttcttcccta actagagtca 243060
ttattgcgga acttgatcat ctccttatgt acatacagac gtaattggtg tctaccaaca 243120
tactgaatgg aatgtagaac atagattgct gatttgtgag ggatcatctg ctgagttacc 243180
ctaacattga tcgctcctgt ccacagagct gggtctacac gagttagcat tcattagaac 243240
tgtgaaggtt tccattttcc tgtcttatct gagaaaagcc caaaaagttt attctcagag 243300
cacaccacag tacaatgtgg gtcactgaca cctgttgctc tctggggact gtaaaggtct 243360
ctttagagtc aagagattaa ttagactaaa agaagggggc aattaagggc cttgagaaag 243420
tgaagaaatg tccatttcca tgcttacatc ataggattct ttgggtaaag aataaactgg 243480
tagagaaggg tctgaggcaa gaaatggtga aggaatgaaa gaaggactgc ctgaacccat 243540
gtagaccact tgtggctact ttggtttcct tctggggtca tgagcacttt gatgttgaca 243600
ttcaagaggg catcaaatta ttatccaaaa tattacaagc cgtaattttt ttattttacc 243660
aaatgagaaa aaactaaaca cagatagaag ccatgagtat ttttctccct aaaaagaagc 243720
tcagaagctg gcccccacat gcatatatac cttgtaaaac gtgagtccct gggctcagtt 243780
tcatggtatg caatggggct gggtcttggg aacaatgctg ctgttgtttc taagctcaaa 243840
cagcactcac catcaatggt atctctttaa gggaaatcca gggaaatgct cttgccagcg 243900
ctgtgatttt atttgctaga ggccaggtgg caatgacatg cattggttcc atagcaacgt 243960
gactgtgctg ccagaaaaca tataatgact gtgacagcca gtgtatcctg ggcaggatga 244020
gggcagccct gataccctct tttatttccc accttatcct ctcttgcctt tcccctcctg 244080
gggcctgtga tatgcggaga atgtggtttt cgtaatggtt actatctact cttgctatta 244140
acacttgcct cctgtctcgg tccatcttgg aacttgatga gagacaaggc aatgcctgta 244200
ggagtgttct gcaggcctct gaatgggtca gcagggttgg cagcacctgc ctgtcttagc 244260
aattgaaagg aggtggagag tctgtgcttt tcatcctccc tgtgtgtggc acagcggctc 244320
tgtcagaatg acctggtggg gagggtactt cctgggcatc gtggtcagct gctcctggct 244380
gaaatgtgtg ggtagtgaca tggagcaatg tgaaatccag ggaaacagag tgctcattta 244440
atatgctgca gattgaggag acacctacca gtggagcctg caatgccagg cccagtagga 244500
ctgcacagag aaatgcaata cccatttctc atcttctggg agctcttacc agagaggcag 244560
tttctaattg cagtttctct actgatgtgt ggttggggct ttcacatttc tctaatgttt 244620
cctcatctat ataatccttg atgaaagaat tgtaagaact cttagttcca acggatactt 244680
tttttcccct ctgaactcct gaagcatttt taaaaatctt taccatccat ttgacattgc 244740
tcttgtattt ccttttttca tatatattgc tttgggggcc tgagtgtttt ctaggtcgag 244800
gctaagccct tcaaggatac gaaacatgta tcttcttctt cctcttaaaa aaatttctct 244860
aatgctcaca actgagttct gcagatagta accatgacat taatatttgt tcacgacaac 244920
gttatattct cactccatct cccaaggaaa ttgtgaggca agtgtgtaaa tatattgaaa 244980
atgttgttca gttcttcaaa gaaaagataa actcaagaaa ttattttcct aatgtggttt 245040
ttttaatgca gatataaagt cacaaggtaa gaatatctaa aggcttcata tttcctcatc 245100
ttcctctttc tggctactga ccatagcata tacccctggg ttttatactg gcaccaaaat 245160
catccttttt cccacctcac tcccaatatt cactgtattg aatttgtctt tgggatcaga 245220
cttctcagtc tagcgttttg gactattaag taagagattt gagggatttt tccattaaga 245280
tgacagatag attaggtttg atagattagg atagtgattc ctaatttggt tttgaggtct 245340
gtttagggga gggaaggttt ttatcttatg gaaactttta tcttacaaga gttctcttcc 245400
cgtcccaagt tctgagccca ctgagaaata agacaagagt attgaggcag acgggggcca 245460
gaatgcaact atgtgactga gggcaatgag ctaacttgac acctgcctgt tccccagtct 245520
agcctggtcg caggccacct gcaggaaagt tttgagtcta caggcacctg tctgtgtgaa 245580
gagggaagga gaaagaggcc caaatccctg ctaaccctgc tcaaaattat atagattcac 245640
cctatccaag gagggggcat aggccacgtt ggctttagcc ccagccgggt tactcattcc 245700
acacccttgg ggaagaaaag gttggagcaa gaggtcagag ggcataaggg aaatcctccc 245760
ccatagaaag ctggggtggg gcgtggcgtt tccttcctgc tctggccata tttctgctcc 245820
ctgcacccca tcaggcctac ccgcccccag ctcactcaag ccttcttacc tgttgttttc 245880
ttcgtggcgc ttgggcttct gcatccgact gctggtttat tgttagtctc ctctattaga 245940
attagctcag tggaagcaaa agccttgtcg gtctcatgga ctgcatgtat cccagtattt 246000
aaaactgtgc caagcacata ggaggcattt gatcaatatt tgttgaatga ataaacacat 246060
agatgttgtt tgatgcctct gctcacactc tttaattacc tggacatccc tggtgccctg 246120
tcttgtctgg caagtctgta ggagctagtt cagcaatcgt ggtctcttct tgctctgtat 246180
gtagctcatc agttggcagt agttggcatg tgtgcatgtg tgtgctctca tgtaggtgag 246240
tgtgcatgtg tgtatctttg tatgcatgtg tgtgcaccta catacctgta tccttttgtg 246300
catatgtatt tgtatgtact tgtgttctct ctctctctgg ctctgtaata cttcacttat 246360
ttgtttacat atcttttacc cttactagat tgcaaatgct tgaagaactg gggaacctgt 246420
taatcattct tgttcctcta atatctgcca tgtagtaggt gctcagtata tgataatatt 246480
agcattctaa gcacttacaa catgcccagt actgctttat tttaaaattt aaaataactt 246540
ttatgtatct tgcatatatt aacttgtgta attctcacaa caaccttaca agatacattt 246600
taaactcgtt ttgtgggaaa ggaaactggg gacatgaaga ggtcaagtgg ctggcccaca 246660
gtctcacagc tagcctgact ccatagcttt ttttctctgc tacctctcag aaactgacta 246720
ctgtatttgt gtgaatgaac aaatgactga atgagaattt tagaagccca gaccaaaatc 246780
attaaataga cctaaagaca ttagggtcaa cacaaataag taaaaatgat gagccatggt 246840
tgacacagaa tcaaggccat ggctaagata aattcacaga tgaatagcta atgccttctt 246900
gtagccattg cacttaattc ctgatgatcc atgcctgcat ggtggtattg gttaatgcaa 246960
atgaataatt gttattacgt attgggaatt atttcctagt gggaaaatat caagtcatca 247020
gttatgagtt aagcagctac tgcttgcgag gctcacaact aaattttggg gaaaatgatg 247080
agaggaagga aaatgtgagt tggagggtga aaaggtaagc cctgaaagta caagccaagg 247140
tcactgtctt caagaggctc ttgtctcatt aagtggcaag gagtgagtaa aagtgacatt 247200
aaggcaatta aaagatactg agggcagtaa atataaagcc tagcacaagg cattgttaga 247260
catgattcat taccaaatgg taataataga gaaaataaaa gctattgtat tagtcaggat 247320
aggataagct tttgttgcag aaaggtcaac cctaaacttt cagtagctta gcaaaataaa 247380
agtttatttc tcattcatac agtgaccgct gtggatgcag tatctctcca ggacaactgt 247440
cctccatgca taactccatg atgcagtctg ctttgatctt tttatccagc catctagggg 247500
cctctttcat gatcactgga agagagaaaa attggaaaat tgcaccagca attcaatgct 247560
tcaaagcttt ggcctagaag ggacacttgt cacctgctat gtcctaagca tggcttttag 247620
ctttttgtat aactcccaac gtcccagtcc tctcacacag cacacagtag gtgctcgata 247680
acgtgtaggg taaaagaatg aatgaactta agaatgcatt gtgacttgct cctgatggtg 247740
ttgtagcagt aatatacctg gcagccccca aagcccaggc ttggaacagt cagatctggc 247800
tcaaaaatat ttactaaaat taaaagagca ttaataaaaa taacaacata gttaacatta 247860
attagctatg gtgatgggac aatcataagg acacgggcaa attaaactca atttagcagg 247920
tggctaaact tacgctaaag ccccggcctg ccagacattg gccttgtctt agacacatca 247980
ctgtctaaca gtccagagct caactcacag ttcacaagtc atctggtccc atcttgtctt 248040
tctgaccttg ttcctcctga atgagatgga gatcattagg cttgttaaaa attaagaagc 248100
tttattaagg caaagttaac ctgtctggga tgcttccatg attccatccc aggtgtatgg 248160
accaccctat accatccccc tcctgcatcc gcttctctca tgctttcatc tttcatctgg 248220
ggtcctggtg aacagaccac aattcagctc cagatcaacg aagaggggct tccagacagg 248280
ggccacgcat atgctgagga aaacacagca atctaacatg taaagtaagt gggaagctcc 248340
gtgtaggact caacacggag aatggacagc tcatagagag aaagggggag actgccttgg 248400
acagggagat aggggtcaca ccacatgtgt cagaccaaag aatggggacc cctcaaccac 248460
attcgctacg tgtgtattat gtggtgaaga gaaacctgcc tgcgaggagg actgagtccc 248520
agccactgac agattcccag gacacggtgc ttcttgttgg tttgtggttt gggggtggta 248580
gtggtaggga gggaggagtg gtcactgtgt aaatgggcag tgctgtgggg aggggtcctg 248640
aactgggggt tggcagtcac tggagatttt tcaacaagtt ggggatgtga agaaccatgt 248700
tttagtgaga tgagctttac agctgtgtcc atatcccgtg agatggtgga gaaaaaagag 248760
actggggtcc cagagggaag gcagttgcag gcgtaaggag ataaggtttt gagaactact 248820
gtgggcgtgt tacaaaggga ccgatgtgga ggacactaca aagaaagagt tgaacaaact 248880
gagcaactgg gtattagaaa caatgaaagg aatggagtca gagataaccc aatttttgag 248940
cctaggtggc taccgaaggt gtcctgtgtt gtactttatg gatattatta ttattaatta 249000
ttattattat tattattttg agacagagcc tcgctctgtc gccaggctgg agtgcagtgg 249060
cgtgatctcg gctcactgca acctctgcct cccgggttca agtgattcac ctgcctcagc 249120
ctcccaagta gctgggatta cagcctccca ccaccacgcc tggctaattt tttgtatttt 249180
tagtagagat ggggtttcac catgttggcc aggctggtct cgatctcttg acctcgtgat 249240
ctgcccacct tggcctccca aagtgccgtg gatattattt taataacagt gtcatcccat 249300
gagatagaga gcctgtggca gaacccaggg attgcctggg acccagatat gcccacgtga 249360
gtatctgagt tgccttaacc ccacctccct tccttcgagc cctccctccc caaggtttag 249420
gatcaaatct taaatcagca gcaaaactgc caggctgaaa tttcatctcc atcctggccc 249480
tctagtggag ataaaatggt ttgaatgtgg gcgagaaagt aaaacggaat gtgtggttgc 249540
tgagtctagc tgttgataag agagggttca ccatccaccc atgagaactg tctctctcct 249600
gctggtgtgc ctcgctctca gacgcagcct ccctatggct ctgggacatg aggggtaatg 249660
tcttgccggt tggtaaaatt cttgcaagct gacagtcttt ttttgttttt ctttttttta 249720
agctccacaa ggctactgca cattgcgttc ttgctctttg tgatccaaca agagggagtc 249780
agttttgatt tgggagaaag gaggaagaaa gctgtttgat gggcgagagg aggcatgtat 249840
tgattgcatt cccgttttgc tttctggggc tggctggtca tgtcactctt catagctgcc 249900
tggctctagt ggtagaagag agtctaatga gagacgctac ggctgtgtgc agcttgcaca 249960
cagcaactct tcagctccaa ggaatcagag tgagctcctg agctccctgg gattcagagg 250020
tgcctcagcc ccaaatcttt ttcccctgca tttaggctag aacaggaaag atgctactgg 250080
gagagaagag aattcctgac atcttgcctt tcttgtctgc tttctgcttg ggtctgtgga 250140
gcagccacct ctgggcagag gtgcaggaag tgtgacagaa caggaaagct ttaaagtcac 250200
tgtctccctc cctcccatgc cctaggctac ccttgctggt cagaacctcc tgcttactct 250260
ggtggacaga cacctgagtt gctgctcttg atgaagtttc tcccacttct tcaaaccagc 250320
aaggcatagg accccacttg gcttggaaga cacgtgacgc tcttgatcat ttcagtccct 250380
tttacatccc cataatatca ccgtggcctg ttagattgat ttgtgagtaa gattccttgc 250440
aaatagcaag atgatcggaa gcctctatct tttccggggg aggtgcatat ttaaacagac 250500
agcctaagct atttatagat tgtaatgtat tgtgttacag ggaaaaggtg gaagtcaaca 250560
gtaatgttct gttccccatt tcctatagtt tcaagcatat tttcttgcta gtcctagaga 250620
ctttaaacat ttagaatctc cagtgatatc tatattcttt tgatgtactt tgtgtagaaa 250680
ctcaagcacg agcaggcttc agagtcagct aaccaaagaa tcttggggct tttgatcact 250740
ttccattagc acaaacagtg atctctgccc tgttgtatat tgtttgaaag gacatttgct 250800
gtttaatgaa gataaacatg ttgctgggtt tttaatatgt cttctcaact caggagctga 250860
aaaatgcata catgagatta gttctgttgg cgtagaaggg attctgcgtg ccccaaacat 250920
tttcctagcc gttggctgaa cttttgaaat gtgctttgca ctgcaagaac agatactgaa 250980
cagatatttt acttagaaag ccttctgttt caatggtgat tcccaggggc cactcaacca 251040
catcttacta aataatattt ggtcaaaaga gaaacgtgag tgcaagaagg acacatgatc 251100
acagccacta acaaattcct agaaagtgct gcttgttgtc atttctggtt aggaggtgat 251160
ggtgatggca ggtagagggt ctaagccatt ctcctgtctc tcttttaaag tacattcttc 251220
tgttgctgta gctcctggca ttggctgtca ccctcacttg caggagggag ggaatgactg 251280
tttgttgctg ttggtgtctg aaaatctgtg ggcagaactt ttagaaaaag cagaccacag 251340
agcctgctat atattttgtt cagcccattc tatttctctt cactttttaa ccgattgcga 251400
caaaaaaagg ggcctgcctt ctaaacttgt ctttatcttt aaaagagaat accttttata 251460
aatgcttaga acttggagat gctgttgttt ttatttagta tttgaaaagc taagtatgct 251520
gacactgtcc tgggagtgca ggcccctcat tgagagagaa cagtaaacac agcaatgact 251580
ttgcttttaa tttgaaatgc gttactcttc ttagagctga ggggtgattt gagatgttcc 251640
tgttttcaca ttcagctatt tcctggttct gtgatcataa taaattccat agctccaaaa 251700
cattagagca aattgtgtct tctgtaggag ttatttacgg atactcaaac aaatggtgct 251760
ttctgaggaa gaagaactgt gtatgaaaac tatgtggtaa agcctttcat atctgccgtg 251820
gtggcagaac ttctgaggag ctggctttga gggtaatgat atctttatca ccctgacgct 251880
gaatggaggc ggggaggcct ttgtgtgttc tgttgccaac taacacctgg ctgcctcagg 251940
gcatcctgcc tggtaattga acccatgagt atgtacaaag attagaggga ccgtttgagg 252000
agaaagatgg gggctggaga ggcaaggtta gtcttgccat tataagctta ggtgcagaag 252060
gaagccaagc tacctggaag gccacctcgt ggcaaagaca cccactaagg cagggcggtg 252120
gcctgggact gaccatcaat cacttcccgc tcattctcct cagaactgag gactgttgtc 252180
ttcagtcttc cccagcctcg cttatcttcc tcctgcttcc tgaaggaaat atccttttgc 252240
aatgggtgga ctatcaactt gaatttttag caagcaggct ggagaagttt ttggaagttt 252300
tggagacatg gctggtcttg aattcctggg ctcaagcaat cctctcactt tggcttccca 252360
aagtgctagg attacaggta tgagaagttt ttggaggttt cggacttgtt gctaggttga 252420
ttctgaggga gaaaagacct ctgttattca gaaggttgtg gacttctgaa gaatggaaat 252480
cgggcaccct gaaggaaaca tatgtcaatc ctagtcctgg agctagcatg gctcaagttt 252540
attcccttaa atgtctattg tgttaaaaca taaaaagagt ttagatatac ttccacatct 252600
ttgcagttgt tagctctctg gacatttata aagggaaagg aagagtgaag cagagcccca 252660
ttaattccca tgcatggtgt ctgctgtttg aatcctggaa atcaggatga ttttattcac 252720
atgttaatgc cctctagtgg ctagtgaggt gccctctaag caggactttc cccagcttcc 252780
accccttcct ctccctaact aaattaagca cccactttac agtagttgag tatgtgtcat 252840
atcaagtctg tattttctta ctaagattca tctaccacgt gggaaaaaaa aaatcaaaag 252900
ctttgttaca gttcaaagaa cgtagtgctg ttgctacatc aagtgaggat aaatcttcca 252960
tctgtagcaa tctgtattat aagtctactg gatgtgacag aaaactcttt aaaactttga 253020
tgcacatatt ttcacagcca accgatttca ttaaagtggg agaagtgtac tattggcaag 253080
cagtttttct gctgacttcc cacccttaaa tagacaagct ttataaaaag acaaaatctt 253140
cccagatcta tttggttggc caaggtgaca tttgtcttcc tccctcagaa ggttggtaaa 253200
attaaccttc tgctttctgt atacctttac tgtattttta tttctattta tttatttatt 253260
tatgagacag ggcctcactc tgtcacccag gctggagtgc agtggtgcac tcacagctca 253320
ttgcagcctc aacctcctgg ggttcaagca gtcctcccac cttagcctcc caagtagctt 253380
gggactacag gtgtgtgcca ccatgcccag ctaatttttg tatttttggt agagatgggg 253440
tttcactgtg ctcctctggt tggtcttgaa ctcctggact caagtgattc tcccacctct 253500
gcctcccaca gtgctaggta taagccactg tgcctggccc tagttttata taggtaaagc 253560
attagtcact cacaatgatc tttgaatgag ttatgtaagt tatgtttggt ttctcctact 253620
ttgttttcct agtcagttca accagtcaag tatgagatga gtggctgctg tgagcttgat 253680
caagtgggtc ggaatcccct gggaatattg ttaaaatgca ggttctgatc ctgtcggtct 253740
gagatagggc ctgagatgct gctggtccca ggaagacact ttgaggaaca agttgctagg 253800
tgatgcagaa gacagaagcc atatttgatt ttcaaaaatc ctatgatctg aaaaggaact 253860
aggagaagta tacaaataag tatggcataa gacagaaggt gataaactgt atataaaagt 253920
aaaaacacgc ttcagagggt taaagataga agtgatcact tctgattggg aagatcaggc 253980
caatttccac agagaaggtg atttgggaat gggattttag tttgcaacag ggattgcggg 254040
gaggcgtgcg agggccattg agaccagaga cgcagattct ggaaagtgaa gagtacgttc 254100
tggaacaagg ggccacccgt atgcctgtga tggggaaaag tgggagataa cagttgggaa 254160
ggtaagtgga agccatattg tagactgtca gacagtctgg gatggaaact ctggacttaa 254220
ttcaggaagc gaagaggaac cagcaacaag agattttgaa acgagaaaga agattgaaac 254280
tgcagtttag aaagattcat ctggcatgta tatgtaggat agacgggagt ggggagtgac 254340
agcccattcc aagagaagga gtagtagata ggacagatag catgattact cttagcaatg 254400
gggaaaatag agactagatg cgatacagag agagaaggat cagaaggtgt ccaggggctg 254460
tcagagtttc agtcctgaat ggctacagaa ttaccataaa taggacagtc agaatgagct 254520
atcgaatgct tttgaatgga aaaatgacct gaatgagtgc acaaatgtca cctccaagag 254580
gccttccttg tccatcctat ctaacatagt atgccggtct tcttaccctg ctttgctatt 254640
ttcatgacac tttttactgt gacattaaaa ggatggcaag aaaaacaggg aggccaggta 254700
agaaacctgt agttgacagg atagaaaatg acagtggctt gggcttgaat ggtggcagtg 254760
gcatcagaga gaggtagctg ggttcaagat acagcctgat agtatccagt atattctcgt 254820
tgtgcatcca gtctcagctg tttgtgtctt gcaaaactct gtacccatta gacaataaat 254880
tcccccttcc cccttccccc tccctcctgg taatcaccat tctactttct gcctctatga 254940
atttgactgc tctagggacc tcctatgagt agaatcacac agggtttgtc cttttgtgac 255000
tttttgttta gcataatgtc ctcaaggtca tccatgttgt aacatgtgtc agaatttctt 255060
tttttaaggc tgatgaatat tccactcttg tatatatcac attttgttta ttcattcatc 255120
tgtccataaa cacttgggtt gtttccacct tttggttact gtgaataatg ctgctatgaa 255180
tgtgggtgta caaatttgag gttctccttt cagttctttt gggtatatac ctggaaatgg 255240
aattgctgga tcacgtggca attctatttt taaatttttt atgaactgct gtatcgtttt 255300
ccacagtggc tgcaccactt tgcatttcta ccaacagtgc acaagggttc cagtttctct 255360
atgtcctcac caacagttgt tattttctgg ttaaaaaaat gtatttgata gtagccatcc 255420
taataggttg gaggtttgag accttttttt aggggatatt tcagatagac agttgagtct 255480
tcaggcctgc agctcaagaa gtctgggcct gcattatacc atagaagttc atatttatgc 255540
catcctttat cctttcaatg aattttttgg ccagtttgtc tataagcatt taaggattta 255600
gagatttcta ttaaaccatc agatttgtgc ttaaattatt taatctcaaa gacattttaa 255660
ataatatata cattaattta gacatactgc tttcttccac tttcatatta tatgaaataa 255720
ttttacttac aacttttatc tactatatca gtatcttcct cacgttttga actacatggc 255780
aggtcatgta gtatcgtttt ccaaagcaca tcatcttgac gttcatctac tctgtgtttg 255840
atgctattac cagaaatttc atcctaagcc gcaagtgccc attcctatat tcgttggtta 255900
catttgttga gaccccattg gccaaaaaaa gacatatagc caagcccaca gttaatgtga 255960
gcatggctat agggaggcat cctacattgg ggaccattat tgtcacaata tcctaaacca 256020
tattattaag agatgttttt cttcattctt cctgtgagtg tattttgatg aactctgcaa 256080
cttaaccact tactgtgttg cttttaaaag taatctttaa aatgcttttt tatttatagt 256140
gacatccagt gcttgcaact aggaaagtca tacttccaag aataattact agtcaaattt 256200
gttttcttcc attaaaaaac aaaaggaaaa acagttctgt taggtggctg ttatataaac 256260
atgccaaact agcatttatc aaggtagttt taaggtaata tgtcttccat aaagactact 256320
ttatttaaga gaccaataga tacaataaac tttgtaagaa ctcaaaaatt aagggtactt 256380
aggcttttct gagggctttc tttggagaaa aattacctta tattatatta ccttttattc 256440
aggcatacat aataattgta aatttggctt tggagacttc agtcaaagaa agagcttcta 256500
tacaggaaaa gcccttaaac actaatatag tgattgagcc cattgctcat aaatgtttgc 256560
taagaaaaat acttgtctgg cgtattcaaa ggtcagtctt tcctagaggc atgaggaacg 256620
tttcagagtt ccttcggaca ttgcagtgct gtggctggat gatgccactt acccatctat 256680
ttatccattt atttattcat taacttcaaa caccttctat agtgcagaga atttctaaat 256740
accatatatt agaaaatctt tattttatga gtttggctga caagggtagg aataacaaca 256800
gatattaaac caaaaagttt tgcattactg aaaaaattgg acaaattcat attaaaagtt 256860
cctaaccaaa aatctcacag atatgatgca gtaattgaaa tccatcatat tctaaggctt 256920
aaagcatgat gatctgcttc tacagtgata atttgggtaa gaaggacagt gttctaaaaa 256980
agcagcctta atatataaca cggaggagta tatgtatttt ggtcaccggc catttgtctg 257040
tccatccatc catctgtcca ttcatccatc cagctgtaca tacatcccta catcctttgg 257100
tttatttcag tggtgtcaac tcattacatg gcgttgaatg atgttatcaa taatcattgg 257160
catgcccttt actcccttag ggtagaagag aattaggtaa aaggtagtac tgaaaaaatg 257220
ttttcccctc ttgctgcaaa gttataagct tttgtttcct aatcaggccc actagaccac 257280
attttgccag tgagcctcca ctgaaacaaa taatgataat gttcatttca catctttgac 257340
ctgggaattg cagagtgatt taccaacatt aactcatcaa ttctcctaac acttctgaac 257400
aagacattat aatatatcat tgaattcatc atgtaaatgg attctgtgtt ttccagagaa 257460
tttcaatatc ctggccacca attacatagg gagtgaggag aaaaattaaa acaaaaatta 257520
cccttttctg aactactgtc ttgtggcctg atctccatca gaatgtctta ttttctggaa 257580
attttaaaag ggggaggtca gaggagacat cagctttgct tatgtaaaac tattaaataa 257640
aatcatacta gagaaaaatc attagaaaat gaccatttcc cttaaaccac tttcttcatt 257700
tgactcattg cttaataaaa tgatgaactt gaaacgatgc tgcctgctcc atgtcaccca 257760
aatgatgagt cacatcatgt gaacaaatgg aaataaatca ccagcgaaaa ggccaaactt 257820
ctgtgctacc ctagaaatat tttctatttt tccagggctt ccaatgatct tccattcctg 257880
tttaactcag cttatagtaa gccctgatgc caagattttc tgagttccct gccaaaacca 257940
tgatgctctc agcctgggcc tctcttctag gagggaagac actgccctcc agatgaagtg 258000
aaaaggagaa tcacaaaaag aggattattc cttatgggag gaaatgggac acgtgctgct 258060
tattgtaaca tcattcgcca ttcgttgggt atatggaggc ttttatgaga aagcagaggt 258120
ttttataact catttactct ggcaagtgaa gcaacactaa aattacttaa gtgtttaaaa 258180
gatagacgca tagtagttta tgttctcagt catcttatta ctgagaccct aatttgcttt 258240
cgttaaactg tcggttctcc ctgagagtgc tattgttatc ggagcctcat aaccgtgtac 258300
acgggtcagt gatggtacaa tatttccgga aatttaagtc ctccataagt agtcaattgc 258360
aggttgtttt aaggaacaaa gactgctttt ccagcaagcc tggcttgtgt tcctattaag 258420
gccccttctt ttttattgca aggggaaatt tcaaaatctc attgctgtat ttaactttct 258480
attttagtag gctgccagtg cacttaacct tccatataaa gcttatatgc gtttatgcgt 258540
tctttccctt attaactttt taaggtttgg gatgtcagcc tgacctaatg atagaatatg 258600
caaaaatagt cctgatacca gcaccctgag cccacctaat aagggacctt tttcatactg 258660
tttacttatt tctgagtaac agaaagtctg atggtttggt gctggctggt taaattcaac 258720
acatggtaag cttgcctgtt agtgaagaag gttgagattt gggctgccgg tatgttttct 258780
tctttcaggc aaggactgag tggcttcccc atgtgtgcct aggtgtccag ctgaccacag 258840
ctgagaggga taagcaggga ttgtgtccag ctgagtttgg gcccctcact cagtggccta 258900
cgttcctcgg agggtgtgtg taattagctg ctgagtagta gaaggcagta gccatgatcc 258960
cagttggaaa atagaagtag agctaaagct aaaaaaaaaa aaaaaaagga aacaggagag 259020
ctgattgcag gaggaggagg aggtgggctc ttgctatttt ctagagcctg aaccaaccat 259080
gcaaagtaga atagcaggtg ttgcagctct ttcccccagg aggactcctg agcctcgtaa 259140
gaaggtcaga gagctggttg aatgttggtg caggaagcac gtcaggaaca gcttaacact 259200
ggtttaattt tcatttcccc tgtgttattt tacacatgag gggagtctga ggctgagcgc 259260
cgtggagagg tctttgtggg gagcagttca cgtcagatcc aggcctggtc acctcctggc 259320
ctcatcccat tcacctgagt gacttgtcac ccttttcaag tccttttcct tctttgcttt 259380
ttgcttctcc aagtgtgaga ttggcaatgt gatcattata tgaaaaacat ttaaaattaa 259440
aaacgattct gtgcaaatat gaaatagata ccagttttct ttgatttctg tagtgtcact 259500
gatgataata tgcactgtag attaaatgat tagtttctgg gggtgggggt gctaccactc 259560
ttttatgtac caatcatata taaaataagt cctgagttca gaaatgttaa aatgacaaaa 259620
atcacatggt tgtcatatat aagctatgtg tgttgtatac aggctgtttg acacacaggc 259680
cctgttcttt acaaggcatg ctttctggaa gcccaaacca gtcccaggag tgaaagctgg 259740
ctcctagcaa tacatgcgag taggagtcag tgagggctta ggaaaattat ccaggaaatt 259800
cattttgagc agcccaaact gctagctagt agctaagcta gtaggcagga gtttcattga 259860
ccacatgtct caaccacatt taccacattt cttgctaaag atgccctaag tggggctgaa 259920
aggcacaaga tatatagcag gtgggggcaa gggggaagtg aagaacctgg gtaccccaca 259980
ccctagatca ttcaattaca tttttaagaa ttttttaaat gtacgtatgt taaaaagttt 260040
cagttttgca aaatgaagag tttggggggt ggatggtggt aatggttgtg catcattgtg 260100
aacgtactta atgccactga ctgtatagtt aaaaatgttt aagatggtac attttatatt 260160
tgtgtagttt accacaattt ttagaagtat atatgtaata tatatgtata tttacataaa 260220
tatttttccc tagtttgatg aaagtatatt gtcatgtcat ccactcaccc atccatcttt 260280
attcattcat tcaacaaata tttatgaagc cactgttagg tcaacatctg tgttccaagc 260340
tggaatataa ctatgaatac attttctgtg cttgtgttac tctgaggtta gtttaagtga 260400
aagccatatg aacaataatt accagccagc gtggtgagcc aaaaatgaat gtgtatgtgg 260460
agttaagact gtgtccagct gtgcagagtt gtggggtgtc ttggcatctg tcaaagagaa 260520
gatggacata aagagatcac ctgccaaggg acagcatgga caaagcacag ggaacaaaca 260580
gcatggtgca gtgtgtgcag ggaacagtca gtactccatt ggtggtaact tgtcatgagg 260640
ccaggagcaa accatagagg gtctcatagg ccatgttaag gagtacagac tcctcagctc 260700
ggtggaggtc agaccacatt ctccagtagc ctgaggattt ctcagtctcc caacctctgc 260760
cctgtgaacc tctgtggggc tgccttcaga agtacttggt ggtgatggat gaggagtagg 260820
aggaaccgat aaaactagat agtgtaagta gcctcaattt tatttatctt gtgtattaga 260880
tttctatata agattttgtt tgaaggcaga gttctggctt ttaaaaaaca catttgaaaa 260940
tcattgctgt tggcaatgag gaatcataaa aaattattat agttggtgac gattagctta 261000
gtgttttaaa aatcaatatt ctgcattcaa agcaataaac cttctttctc catttctgaa 261060
cctcacctca cagtactttg cacatactaa gcattcaatg aaatgttcag tgggaattgt 261120
tttagggcta tgacttaggg atattttcat tatactactg tcataagggt ccacttaaat 261180
agaatgttgc ccagtaactc aaaaggaatt tgtagaaata taaactatat aacttgcctt 261240
ttattctcac ttttctttgt gtgcgattgg actgtaataa ttattttttc tgagttttct 261300
tgtctatttc tgagacatca ggttttataa tttgatgctt tggacctggt tgacaattcc 261360
gattctgtat gtaggattga actttgtggg aaatagcagt taattgtatt ttttaatgct 261420
taaaatgata ttctgggcaa gttttgtttc tttacggtct atagccagaa tcctactgtt 261480
tttcaatttg tttaaatgca acagcttata cagcatatgt acatgttcag ttgaagataa 261540
aggatatcat tatttttagc ctattacaaa gaaaaccaca ttttctctta aatgtcttga 261600
tataaagtaa tttgaacaca atttctgcac aaatcatttt caagagattg gctgtcaagt 261660
gtattttttt aagtagcact ttcataagaa ccaatgaaac tttgcaaatt tagatagatt 261720
ctaagcctga aatgtggttg aagatgtcag tttttaaaca gcactttgag aagtagttaa 261780
cttaaaagta tagcaattca gagcatactg agaatgattt tgaagagtaa agtcttgata 261840
cactgaaaag aaagttgaca gattcactac aattaggaga caaggaggta caactcccac 261900
ttgtgaaaac ttttctcatc taaccaactt ctaatacttg cctaagaaaa tcttcagcaa 261960
atccttactc ctttgcagct cctaaatcta ttgtatagaa ttcttccagt ttcctaatag 262020
atgctggcga ggctgtggag aaataggaat gcttttatgc tgttggggga ctgtaaatta 262080
gttcaaccat tgtggaagac agtgtggcga ttcctcaagg atctagaacc agaaatacca 262140
tttgacccag caatcccgtt actggttata tacccaaagg attataaatc attctgttat 262200
aaagacacat gcacacatat gtttactgca gcagtattta caatagtaaa gactggaaac 262260
caacccaaat gcccatcaat gatagactgg ataaagaaaa tgtggtaaat atacaccatg 262320
gaatactatg cagccataaa aaagaatgag ctcatgtcct ttacagggac atggatgaag 262380
ctggaagcct cattctcagc aaactaacac aggaacagaa aaccaaacac cgcatgttct 262440
cactcatagt aggagttgaa taatgagaac acatggacac agggagggga acatcacaca 262500
ccagggccta tcggtgagtg gggggcaagg ggagggagag aattaggaca aatacctaat 262560
gcatgagggg cttaaaacct agatgatggg ttgataggtg cagcaaacca ccatggcaca 262620
tgtataccta tgtaacaaac ctgcatgttc tgcacatgta tcccagaact taaagtaaaa 262680
tttaaaaata ttttaaaaat aaagaattct tccagtttcc ttatggcata ataatggaaa 262740
cagaataata acatgacaac cctcctttcc ttgttttaag gaaaagtaag ttgttaggcc 262800
tgtgaacaat ggcagaactg aaatggagtc ttcactcaag ccttgtgtgt gattgtgtgt 262860
atgcatgtgt gcatgcgtgc atatgtgcac actcacgcac atgcacaaac ctacacattt 262920
gagtgcacca gtttaaaata agagaaaaaa gtgacatgaa actcacttcc caatttctac 262980
catcattaat aatacatttt accaattctg atttgttcta ctattgtgtc aaggctagtt 263040
aatgtgcccc atgcattggc agacaagatg atattatgtg gaaattgtgt cttgtctatt 263100
ataagaacct gaatatttaa gtatgggaga tttttgcctg atattcttca gtcttgtcac 263160
tcactactga ttaagctttg taatctatat atgggcatta gatgaatcca taaatgaatg 263220
aattggtagt ttcctcaatg tttttttttt tttttttttt ttatcataat gaagatattt 263280
catgaccttt taccagtctt atcacatctt ggaaagaatt actacatctc tgaaaaccct 263340
acccaggtac cttcttgtag ttgggccata tgtttctcaa ttcagatata cccttgaggt 263400
ccactttcct taggtggaca tacacttatg tacactcaca cacccacatg catacaatat 263460
agagaaagaa aggtaaatag taaccgacag aggtagtgcc tgctattctc ttcagcgagt 263520
tgttatcccc tcgtcccatt ccacaagatg ggtgccacat tgaagatgca accaaattac 263580
atgcccacac tcacagtggt tggccctttt gaaattactg ggagattata atgatacaga 263640
ctgtggggtt gaaacaattg tattaaaatc aattttctgc cacttccaag ttctgtgatc 263700
tagggctgtc gcttaattaa tctctcagag tttgtttcct cgtgtgtcat atgggaacaa 263760
taaacttact ttcacacggt tgttgagaag agtgaatgat aactgataca agaaattcaa 263820
gttttgttag ttttaatcgg acatcataag acttttaaaa tcatgtaaat gtacatccct 263880
aattgcttgc aagtggtgca aggtgacaag aggagccacc tttgtgggag gagtaggtgg 263940
caacctctga tgacttcagg acagtgactc tccaccttgg ctgcatagta gaatcacttg 264000
gggagctttc caaaattcta ttgcctgagc cataccccag accagttaag taaggatctc 264060
tgtgggtgga acccagacat tagtactttc taaatctctc tgggtggtca caatgtgtag 264120
ccaagttgga gaactgatgc tttaggggga tttaaaagtc ttcactcctt gcattggctg 264180
aattgatgat agccagaatt ctacaaccta cactgtattc tttttgctta agataaacag 264240
agtcttaggt atcatgccaa aagtctatta tttctcttgg ttatacacga tttggcatga 264300
attagtttat taagttttct ccaaagagcc aatcttaatg ggtgggtgtc gggcttggaa 264360
agagaacaga ggtctgtgga tatctgaaga caggggctgt tcactagagg ggcacaaaca 264420
cagaggcaaa tgcaacccaa agtcagcaat ttcaagctac tgttgctttt gaaaattagt 264480
tcttgcaaaa gcaccacctc aagaggtggt tggcttccct gaaagctcag catcatggct 264540
ctggtgggtc atcattcatg aaaacttgct gcatctttaa aatgtgggat gaggaaaaac 264600
atttaaatag tggctgaata cagtcatagt gtaaccaaaa gccagaaaat taatttttaa 264660
aataatgtat atttttaaag ttttgttttt tcaagagaaa agactaaaat cacttcatac 264720
tcaaaatctc tcttacctct tttcaacaat tggtgctgag acaatggaaa aagtcacctg 264780
ggacacatgc cagagaaaga agttgaaccc ttacctcaca ccatatacaa aaatgaacta 264840
aaaatggatc aataccctaa atgtaggaac tgaaactata aaacttttaa atgaaaacag 264900
gagtaaatct tcatgaccat ggatttggca atagattctt agatgtgaca ccaaaagcac 264960
aaacaacaaa agaaaaaaat agatgcattg gacttcatca gtatcaaagc ctttgtgaac 265020
caaagggcac tgtcaagaaa gtcaaaagac agcccacaga atgggagaaa atatttgcaa 265080
gtcagtatct cataagggtc tagtttctgg aatatataaa gaactcttac aattcaaaga 265140
gaaaaagact aacaacccag tttaaagatg gacaaaggca ttggatagag atttctccaa 265200
agaagatata taaatagcca ataagcttat gaaaagatgt ccaacatcat tagtgtttag 265260
gggaatgcaa atcaaaacca caatgagata ccactttatt atggtcaccc attatgatgg 265320
ccataatttt tttaaaaaag gaaaataaca agtgttggca agcttgtgga aaaaatggta 265380
atcttcctac ctggctggtg ggaatgtagt atggtgcaat cactatagaa aacaatttgg 265440
caagtcctca aatagctaaa tacagaatta acatatgact cagtagttct gctcttaggt 265500
atacactgaa gagatttgca aacaggtatt caaacaaaaa catgtacatg aatgttcata 265560
gcagcatgat tcatagtagc ccaaatatgg aatcatccca aatgtccatc aactgacgaa 265620
taaataacaa aatgtggtat agcctacaat agagtattat tgaaccaaaa caagaatgaa 265680
gtactggtac atgttacaat atgaatgagc cttgaaaaca ttatgccaag agaaagcagc 265740
cagacacaaa aggccacata ttgtatgatt cagtttatac acaacatcca gaatagacaa 265800
ctccttagag tcagaaagta gattagtctt tgccaggggc tgagaggagt gggggacagg 265860
gagtgactgt ttcatggata agggggatga tgacaatctt ctggaattag atagtgatga 265920
tggttgttca acatgtggat ggagtaaaag ccactgactt acacacttta aaaacagtta 265980
aaatgctgaa ttttgtttta tgtgaatttt atcttcatta aaaaataccc ctttgacccc 266040
atctcttctc taatcctgca catatagcct taaaccagtc attttaccct ttgtgattcc 266100
attttcatct tattctgttt tttcctctaa tgttcaactt ctgcaaagag acatctacac 266160
tggtcttcat ttcctttcca gcccttccat tcatcactcc agattctaca cctgacctgg 266220
aaaggtctgt gttaactcaa acagaagctt gggcacctct tccttactag aagggcattc 266280
cagtgattga cattagaaat caagttccca gcatggccct gccaccaggc tggactcgtc 266340
cattgcactg tcaccaagga atgttaagtc ttggaaacag atggaggaac ttgcacggcg 266400
tttcccagca ggcacaggcg attcctgcaa acttaggaga gtgaaagtca cacgaacaag 266460
aatgtaaatt tgtgtgagaa gacgtgatgc tgttactagc agagttaaag tgcttttaac 266520
tttggataat ggatagtctg ctctgattgc ctcgaaggtg gatctccaag cccacagaac 266580
ggtctaaaag tggaaggaag ctgtattaat catttattta attttctttc tttctctctt 266640
tttctgctgg ggtcagcagg aatgggaatc tttttttttt ttctttttac atcagtctta 266700
ttatgattat gattatactg aaagacctgg atgggaggaa tgctgcaatc tgaattaaaa 266760
atagcatttt ctgtcctccc acacacaaca cttgagtgct ctgaatgcct tttataaatg 266820
cagactttct gcctggctag ataaaagaag ctgtcacttc atttccataa cgaagtcatt 266880
cccgggagaa ttccattgtt ttagcaatag aatttttgta aaaggcctct tattttgcct 266940
gaaaaaggta acaaaaatga acttttgaga gcttattcga caaaacaatt aagcagtgaa 267000
gagagatttt ctcctttttt gatatattag gagttgtaag tgtgagaatc ccctgagcca 267060
tgatactagg ataaacccct aaatctgcaa gatgaaggag gaggggagaa atcctgttat 267120
tctttctcct aatagaaatg gggatatgct cttccccgag aatatgtgtc ctagagccaa 267180
gtgacacata gatgatgcta attctaaaga gttttaaata tttagtctta aagagaggta 267240
ggaaacttgt agaatgctca tggtgtaaag aaattccttg gggtttttaa tgaaacgcga 267300
tcatcaggta ttttaactga gtttcaggac tcttaagaca aaccacggct gcatcttgcc 267360
agcgtccttt actcataaaa tagtagttga tatttttctt tatttgcatt gaaattgcag 267420
caagtggagt acagggtcct tcatgatgca gtgtgacctg tagcgagctc agacaggcct 267480
gtggacatgt ggtcacactc agcacccctc tcctgtgttt ccccatccct ccacacgatg 267540
gatctgtgct ccaaatatgg tatcaaatct tcagcgccac attcatagaa agaaagaata 267600
attgtatttc ttgttactta cccggccctg cgtaacccac atcaaagtat acctgtcttt 267660
ggtgtttcaa caggtaatcc ctagatataa tgccaagtgg catttctgct acatggtatt 267720
cacagttaag accattgaaa tcccagtttt aagctagaat gcttttatga agcctcctcc 267780
aaaaaaagag aagttttcaa tagcaccttt gtcttgcaat actttgttct gattgagtca 267840
gaaaattgta atatttaaac aaggaggcag ttactcggaa tagtattaaa aaaggagttt 267900
aaagtatgga gttgttgtat ctgttggctt ttaatttagt aaaacaagta gaccaaaaag 267960
aaaatgagtg ctgttgacgt aatattatta tggaaagttc tgtgggggca aacattatgc 268020
aaaagtagtt aaatctggca ctgattttga atttcagaaa ataattctgt tgtttttgag 268080
ctttgaatgg cttttactaa tataccaata ataacttttt tttttttttt gagagagaga 268140
gagagagtct cactctgtca cccaggctag agtgcagtgg catgatctcg gctcactgca 268200
acctccgctt cctgggttca agtgattctc ctgcctcagc ctcgtgagta gctgggacta 268260
caggcgcctg ccaccatacc tggctcattt ttgtattttt agtagagaca gggtttcacc 268320
atgttggcca ggctggtctt gaactcctga cctcaaatga tccacctgcc ttggcctccc 268380
aaagtacagg gattataggc gtaagccacc acgcctagcc ccaatactaa ttttttaaag 268440
catgatttga tgtcccagct gtagccatgc aattttgcat ggtagtagtt cataaaaaga 268500
aaaggaagtt gtggctttga taggatgctt ccaaggtcgt gtttttaata cttttggtaa 268560
attctgttac ttgtgtctgt tcaaaaggac agaggttggg agatgcatat gtggattctg 268620
tctcttcatt ttatcttcac tccccgtttg gtactttgtg aagtcaggcc aaataaaata 268680
gttgaagata ctatcatata actctcaata ttatggcaaa aagagaatga gaggaaaata 268740
tttagctatt tcttttttag gatttttact aattgtgtta ttaaaaagga gcaaatagag 268800
caggaactga aacagactta aagtcagagg actggactgc acacattagc atcttgcaga 268860
ccttagctgc tcatgattta taaatgcttc agaaattatc aaagcatgag gcacaggctg 268920
tgtttcagcc ttccccattt tcaccaagca cttctgcaac acctaaacac tgaccttttc 268980
aagcaggcat gaataaaact ctcctctggg cagaaggtgc gtgatgactc atggcaacca 269040
gaaaggggat gtgtaactcg ggatgtggag tctctgggct tctagaccca gacctccctg 269100
tcttctggcc cactgttctt tctgttgtgc tacagcaata cctgaaggac ctgcgtgttg 269160
aacaaataag gccaggaata agttgtcaat aggagcacat gacatcttgt ctttaaaata 269220
ctaatttcct gagacgtcgt tctacagctg ctcagcacag attgggtatt tatcatctat 269280
atgttcaact tacattttat tttcatttta ttcttgatat gcagacatac ttttctccaa 269340
tgtataatta tatttcatag caaactttgc actacgtcca taaggagatg taacctgcat 269400
acaaatacac acagcagcag tctctgtatg aataaatcct tacctttatg tgataagcca 269460
tgctaatgat aagaagcagt gacatggatc aacatgaaat ataatttttt taaaaaacct 269520
ttgaggatag acatttttcc agcatattta tctctgataa tgtgttcttt aggccggtac 269580
taattttgga ttttattcct tgaacacaaa ccagttaata tacacagaga atattctgag 269640
tgcatgctag gtatccaagg actgccagtt tgtaagaaat tttacaatgg ataactccca 269700
taaatgatca aatgttgact gaacagggaa cgcatgatat tgtgaataaa tcatattctt 269760
cagaatacct tgagttttgg cctacctccc acgctgacct ccctccaact cttcttgagg 269820
tctaactgga ctctcagtcc agccctgcac tggagatgcc tctcagtcca gccctgcact 269880
ggagatgcct ctcagtccag ccctgcactg gagatgcctc tccatgggaa aggggtgttt 269940
ttggcccagt ttgcctgcca cttaagctcc ttggtgggca gggtggagac agggctctgc 270000
accctgctgg gctgagtgtg ctcattcaga ggaagcattt ctgaactctg caattgccag 270060
cagccctggc agcttctctt tattcctcag aaaggaaata caaagagtta cctttagttc 270120
tgagttggaa aaagaggctg ttgtggaaca tttcattgag ggactgcaca gtttccttag 270180
agacttatgt gatgattttt ctccaagtca cccaaaaggg tgttcttcca tttgaacacc 270240
tgtcctcttc catggaggac agagactcaa agacatataa cgtcttcaag tataatgtaa 270300
tataatacca tgttatcaat cagttaatca acaaatattg atcaaagagt tatcatttgc 270360
gaaagccccg tgaagcttac aaaaagaaga cagacataaa ccctaccttt acggaagtta 270420
ccacattcca cttggggaga tgacacctat tgtaggataa ggaataaaat ggttagtaac 270480
ataaggaaaa tgaattttaa aaccataggc attcacatgc aaaaacaaaa caaccaaaaa 270540
aaaaaaaaaa aaaacttctg attgagaaag ttgtagaata agaggataaa agagttgtag 270600
aaaaagtggg atttgagctg gtcttgggag gtctggctta cattttgaca cgtggagtag 270660
aaatgcgggc tctcagagag gaagtgagaa gctcactgtg gctgcttcag tgtgcatgag 270720
gggagaagta gaaatgaagt tggaaaagca tgctggggcc agattgtgaa gatcttcagc 270780
atcaaataaa gaatttcgaa gatgttcagt aagctgtagg aaccaatgaa ggtatggatg 270840
gcacggggaa gttgtgttat atctacttta ggaagttcga tccaacaggg atgactcaaa 270900
tggtttagag agagaaagca ttgacaagaa gaccaatgag caggctgctg tgagaggaat 270960
tcagtctgag ctagcatggg gcggtgaaga tagaaagggt gcagaattgg taggacttgg 271020
aaaccgatgg aatgtgggag aaagagtaga agatgatgat gctgtcagct tccatcagaa 271080
attaaagagg aggagctggg tttggagcaa gggactggga aagtttgaaa taaacataat 271140
ttgtttccac tgcatatatc caggagtttg tagggggaga taccagggac caggatacag 271200
atttaagaac gataaacagt agaaggaaat cattatagaa agtgaataga actgagcaga 271260
tagccttagg aaatctgtcc cctagagtta gaaagaacag agagagcaaa aaactgcaga 271320
ggggccataa ggagtaatat aaggaaccca agaaagtacc atctcagaga aattaagaat 271380
atttgtttat tttggttaca atagacaaat taaactcaaa gtgattcaag caaaaaaaaa 271440
aagaaatgta ttgtattata tgtggattgg ttttctattg ctgtatgaca aactacaaat 271500
atagtgactt aaacaacacc tatttatttt tttttgtgtg tgcatctttt ctttttttat 271560
tttttatgtt attattatta tactttaggt tttagggtac atgtgcacaa tgtgcaggtt 271620
agttacatat gtatacatgt gccatgctgg tgtgctgcac ccattaactc gtcatctagc 271680
attaggtata tctcctaatg ctatccctcc ccgctccccc caccccacta cagtccccag 271740
agtgtgatgt tccccttcct gtgtccatgt gttctcattg ttcaattccc acctataaca 271800
atacctattt attatctcac agtttctgga ggtgcgaagt ccaggcatgg cttagttgaa 271860
ttatctgttg gaggtccgaa gtccaggcat ggcttagctg aattatctgt tcagggtttc 271920
ataagactga aattgaggtg tcaacagggc tgccttatta tctggagctc atggtccttt 271980
ttcaagctca catggttttt tgtatttagt ttcttgtggt cgtaggacca aggtcccgtt 272040
ccattgctgg ctgtgagctg ggggccactc tcaggtcctg gcattcacct tcagttcctt 272100
gccatatgac ttgcctcctc catcaacatg tcctctctca ctttgaatct cattcctggt 272160
aaagccccat cccttttagg gttctcttaa ttagatcagg ctcaccaaga taatctctct 272220
attttaaggt tggttgactt tggacctcac ttatatttgc aaaatccctt cacaacagca 272280
gaaccttgat tactgtccca ctgactaact gggaagaggt gtgtgtctgg caggggacat 272340
ggcaatcttg tgggctacgt tagaatttgg tctatcataa tataactaaa aattccaggg 272400
atcaggccgg gcgccatggc tcacacctgt aatcccggca ctttgggagg ctgaggcagg 272460
tggatcactt gaggccagga gttcaagacc agcctgtctt gaacatggcc aacatggtga 272520
aaccctgtct ctactaaaaa taccaaaaat tagccgggcg tagtggctgg tgcctgcagt 272580
cccagctact caggaggctg agacaggaga attgcttgaa cctgggaggc agaggttgca 272640
gtgagctgag attgcgccat tgcactccag cctgggcaac aagagcgaaa ccttgtatca 272700
aaaaaaaaaa aaaaaaaaaa aaataataat aataataata attagccagg tgtggtggca 272760
tatgcctata atcccagcta ctcgggaggc tgagtcagga gtattgcttg aactcggagt 272820
cagaggttgc agtgagtgag accgtgccac tgctctgtct gggtgatgga gcaagacttc 272880
gtctcaaaaa aaaaaaaaaa aaaaaaaaaa tccagggatc cgtctaactt ctggcatggc 272940
taaatccaag ggactttact gtcatcagga ctcagatttt ctgtctttca gcttttctct 273000
gtactgggaa gcttccttct ccagtgggct ttctgtaaga ggtggctaaa gaaaccagct 273060
gttagtagca tcatgctccc gtggtctcac taggaaagag tgtgttgctc ctcttagttc 273120
caggtagtct gagagaggcc tttgattggc ttgccttggg tacatgccta cccctaggcc 273180
agtcactgtg gctggagggt tgttgtatta cgattgccca gacctgggtc atatgtccat 273240
cttccaggcc aatgtgtgaa gtcatcccag cccagataac agccaagggg agagatcatt 273300
ccagaaaaga tgctgttcag gcaaaaatgc tagtctacta aataaaagga aaagaaaatg 273360
gaaggaacta ttactagtga actgtatcag acattgttag agaagttaag aggaggactc 273420
agcaaaggtc actgcattta gaaggcagga aaccattctt gacctttgga ggagaaggaa 273480
ggttactaac acagagaaaa gtggtggaaa tcaagctcca gagttttaag atgtaggcgg 273540
tgaaatactg gcattgaatg tatagtacaa ctgtttgttg gtaaacagaa gagagaggac 273600
agccatttgg gactgtatta gggtatggat aaattctttt aggaatagca gtgactgagt 273660
atgcttggag tgtgagaaat ttccagtaga gaggaaaaag actgaaggga agttgggagc 273720
agagttgacc ccagcaggat ctggaaccag taggaggaga atggattcag actccaagta 273780
gagaggccac acacagtgta ataacctggg taatatagtg tgtgaagttt tttgttgttt 273840
ggtttttggt tttttttttt ttttttggtc atttgtcgct tctttgaaat agacaggtat 273900
cattgctttc aatgtagcta tcaaatggtg attaaatgta ctcaaaagat cctcagcatc 273960
tctctggccc tgtaattgac agaaacattt aaccttagag aagtggttct caaagtctgg 274020
tccctggacc agcagtatca gcatcacctg ggaacttgtc agaaatacaa attatctgac 274080
cccaccccaa gcctactgaa tcagaaattc tacagatggg tcttagcatt ctctgattta 274140
acaagaccct ctagccattt ctattcgttt ctttcctttt tttgagtcgg agtcttgttc 274200
tttcgcccag gctggggtac agtggcgtga tcatagtgca ttgcagcctt gaactcctga 274260
gctcaagcca ccttcctgcc tcagcctccc aaagtgctgg gattacaggt gtgagccact 274320
gcacctggcc ttctccagcc atttctgatg ctgcttcaag tttgaatatc actgcctcag 274380
aggtctgcat ctcccctcca catgccatga aggtttcctt aatagtggct ttgagaagct 274440
atgagagcta gtgatgtaag ctgctggtga tgaggaaatg ggggagtttg taaatcttga 274500
aaggagatga caactgttca aattccacta atgacttaag atgtaatgga ttggaagaac 274560
agaatagaaa ggctaagttg taatttaatt ttttttgagt ttgtggaggg ctgacacatg 274620
atgatgatag gcatcatcag actttcaagt ccctggaaga cagagaaagg tgaaatgggc 274680
ttaaagcata gctgtagact ggtgattctt ttggagtaag ggttaagtcc tagaacaggt 274740
tttggatatg gatcatttaa gttaaatcca ggctcttcca ctagatgctg ttaggaggtt 274800
gcaaaagaag ggcatggcaa ggtttctttc atcagagagc ttagaaactt tttgagcctt 274860
caagacttaa ataaatccag tggagtataa aaagacagta taacaaagtg ctgaactgaa 274920
aaggaccttg ggtcagaatg tgtggtagag actgtaagtg ctgtgggcag tcaggggaag 274980
gagaaattgg cattgtgtca ttttctcctc taggcagagg atgaaactga cagcctggcg 275040
taatttccca ggtccgatgg caagatattg gacaccttgg cttcaggaag tgctttttct 275100
tgttctctct ctcctttctg agtgtgtcaa agttgccagg tcaaagtgaa ggtttatact 275160
ctgagacttt gaatgtggaa tattgttaat atttttgttt gtataagaag cttgtaggat 275220
aaattacatt ttatcttgga cattttaaat ggaaagagac tcaaatagaa gtttggcata 275280
tttgtttcag acaggctttc agacttactc cattcatggg gagaacatga atgagcctgt 275340
tggatgatgc tttaatgttg taggatgaag aaagcaaact actgattttc cttagtggaa 275400
gaattaagtt gagccagatg tgggatgata gggaagaaga aaacacttca gatgaacatg 275460
acatttccac tgcttttaat ttctttgcac cttgcttgcg gctcatgtgg gtaagtaaac 275520
agaccactga accaagaacc aagagagaag gttgacggaa cactgttaac ggtgggcata 275580
aaagctgttt aagtccaaga gagaaatagt aaaaataccg taatcatcaa ggggaagcca 275640
gaaatctggt acctgatcca aggtcctaaa gatgtttttc agaagtctac aagtaatgtg 275700
atctgttttc agtccttttt gggggagggt tttcttaact tcagctgtgg catgcaggtg 275760
tcaacaagag agcttccttt tacttcactg tgataacgga gtgacttggg gtgcattaga 275820
gagcagggtc attatttgct gtcacatcaa gaataatacc tgcatcaggg gtgttcctct 275880
caccgaaatt aatcacagag aaggtgtgtg ttgctctgat ggcctagcag tcagaaagat 275940
gaatcatctc ttatttcaag gtatggagaa cagttgtgtc actcatttct ttttcaagga 276000
gactcagttg aaatggcaaa ataaaaaaga gagaaataac agaacacagt tgtacatcac 276060
tagatcagtt cgtataatac agactgtttc ctctacctgg aaacctgatg cctggctaac 276120
ttctgctcat ttttgacttt cctgttcgaa tgttagtttt gtaagagaag ccttcctgag 276180
accctccttc taagtgaggt acccccatca tgactacaaa tcacaatgtt catttttcct 276240
tcatattgcc tatccagttt tcaaatttta tgcatctcct aaaactcata taattattta 276300
attctgtccc tcttgaggca gtgagctcct tgggtgcagg gtcctgggct attttgttta 276360
ccatgtattc cccagttgaa cacagagcct ggtggattta gcaagtacca agtaaaattg 276420
tatcaagcga atgatttaat taatgagaaa gcacttggta aactgtattc attatgaaag 276480
tgatggttaa ttatgtgagt agcagacacc tcctttctct cttctgtccc aattttgtct 276540
ctccattttt tattagttct ttattttgag atatacttgt cagtgtgtta ccaattccaa 276600
atctaagatt tgttattatt cattcttgcc tttttttaga gataaaggac cactcttttt 276660
tgtttttttt cctcagaaat gctattaatg acacccacaa tgctaatact acaactgttt 276720
tttctgtgca tgctcatgat ttgaaaggaa aaacatgact ggcctttgtc gatgatgtat 276780
ttgggaagca acaagattct agtgtagcac ttaaattctg tttcttgtca tcctcaaagc 276840
tgctaataca agttcctttg cctcaagtgt gcttctcaaa agtatacaag gcgaaataag 276900
ttgatagtat cgttccagga gaagctgttc ctgggtcagc cttgaaaggg ggaaaaaaat 276960
caagaaatcc aggtgtggaa aatattaatg atcaggatat gaataagtct tttcattaaa 277020
agcaacagca aataaacaaa aagttatcca atccttttcc agcagggcct cgctgtgcca 277080
ctctggtggg tgtaagtgtt gtcttcggtg ggcggaaatg gcagacagcc aagtggaaaa 277140
tttcacagtg tcgcaaacat tcagtgcacg aaacgctgca aaccagcaat ctgagggagc 277200
cgtgtaccaa ataaccacgc tcctgcatgt gccctactgc ccaccttaca ctctttctcc 277260
tagcttcctg cgtgatgcct tcactttctt tttcccggag attccagatt cttcgtttct 277320
gttcctattc tttcctgaaa ctcagcacag tagggcatgc agacgtttgg atgctcccgg 277380
gatagttgat gattggtgcc ttaccagtgc tggcttttgt attctggctc cagagctcag 277440
gaacaggctt atgaccacca acaacgcttt gcattaacat agtggatttc ttctcgggaa 277500
ctgtgtgtgc tttgcaagaa tgatcttctt gatcttctcc atgacccagt aagatatgac 277560
agtggcagaa ggtgctagtc cttgcctcct tttgcagaag agtaaagcca agtggcctgt 277620
tttgaggctt ttgcaagttt gcatctcagc taagattgtg tctgaagtct cccagaaatg 277680
gcttcaactt tggggtgagg agaggctggc tgtaccatgt tgtgttcttt ttgggaaaag 277740
agcaagaaca ttgaacttct tttttaagaa aatggtcttt ggtgaactat caattcgtct 277800
aattggtcgt gagactgtat ttgttcagat aacaagtgat ttgatgatgt gtttaccttt 277860
ttctttttct tctgttctat ttccatgcta ggtatttctc acttctctgt gaaaggaaga 277920
aagaacacgc ctgagcccaa gagccctcag gagccctcca gagcctgtgg gaagtctcca 277980
tggtgaagta taggctgagg ctacctgtga acagtacgca gtgaatgttg taagttaaca 278040
accaagaaca atatgtgtag tggcttgcct tgtaggattc atgaatcact tgatgtaacc 278100
gagccaggtg ttgaaggggt attagcatga gctctaggtg atcgtccaat taatttcttt 278160
ttttaattgg aagggaattt aattttttaa gggaagaggt cctgtttgta tttgctggaa 278220
cttgcctttc tctcggcttc tatggcatgc tgcaaactat ctacttcagg aataaaagga 278280
tggaatacag tgattctttc attgtaggaa caccttttct actggtacag tcaaatagta 278340
tcagatttag agcagcccct ttaaactggg ctgttgcagt tcttttaggt tggtgagtag 278400
ggggtaaaat tctccaggct aaggattagc aatcagagtt tccatccagc aattattctt 278460
ctgtatgtgc agttgatgaa aatgacattt ttctctctgg cttgtaaaat cttgaggtat 278520
gcaagttaca agcagttatg tttggtgctt cccttactta aaatgagctg atttactggt 278580
tttgatcagt tactggcttg ggattttgag attagtaaag tttgttccca catgtcacct 278640
gatggccgcc ttgcatgaga agttttagtg tcaggtaatg gaagagatga catagtgtga 278700
cttcagggag cccttccact aggaaataat gcaaaggtgc tcagccctcc tactttctag 278760
agaatttacc ttgttgctgg actgtgtcac aaaacacagt taggagattt tgaccaggaa 278820
agaaaatagc tacatgaaac ccaggatggc ctatgaatac ctctgaggac gagaagatat 278880
tatcttcaaa ttttaggaaa tgacaagcca atttcttcta ggtttttgtt gttgtttttg 278940
tgtatatata aatacatata tttctgtaat atatatgtat actcttgttt atgtatgtgt 279000
gtgcgtgtac acacacacac acacacacac acacacacac acacacacac acatatatat 279060
ttaggtttcc agcttcttaa ctcagccaga aaactttttt gaacatgtat tacctatttt 279120
ttttgcagtt gcctacaaga tttgtaaaga gcaaagtgta gcatatatca gggagaaaag 279180
tattgacaag gaaaaaaaat gttcctaatt tttttggttt catagatttc taaacatttg 279240
tattaaaata tgcatatgta tccatatcat ctcctcaggg ttaaataatc agtaatatta 279300
atatgagctt attaaattca aattttccca gtgcttcatt gaaagcagac agtgggagac 279360
actgaagctt cattgtgttt ccattctgta cacgttgggt ctagtggaaa tcagtcagcc 279420
tggaatcagc tgacctgaat cctattccta ctgttgagat caagtacact ggcaaccttg 279480
ggcaagtcgc gagcccccat aaaacaatat tttgcaagtc tgtgtattgc ttcatactac 279540
cttattttca tttttttctt tttaattgag gtggtgcctt actctgtcac ccaggctgga 279600
gtgcaatggc aagatctcga ttcactgcaa cctctgcctc ccaagctcaa gtgaccctcc 279660
cacctcagcc ttcagagtag ctgggaccac aggtgcacac caccatgcct ggctaatttt 279720
ttgtattttt ggtagagaca gagtttcacc atgttgctca ggctggtctt gaactactga 279780
gctcaagtga tcctcccgcc tctgcttccc aaaatgtttt gattacaggc atgagccacc 279840
atccccagcc catactacct ttttattaag caatcagcat cttggtttag ggtcctcata 279900
aggggaagag cattgtgaaa gcactatttt acttattttt ttaaaaaaaa ccttattgta 279960
aaagtttctg tcactatcaa ggaataattg tgggccatgt tagatttggg tactccagtt 280020
acagtgtgtt ttactagaaa tcattttccc aatcaggtaa ctgttagaat gcacttctgg 280080
tggtattttt taaagcattt ttatcctagg aaacaagtgt cttatgtaaa actgctttag 280140
gtttcaggct ctatttaaat aactcatgca gttaccataa tcaagatagc ttttgtttca 280200
aatctagtgg gggttttttg ttgttgtttt aaccgttgct ttgaactgtt catgtgacac 280260
cctgtcagac ctcaaagatt gagtgaggtt ttcaaaggac ttctgaagtg tacactttaa 280320
gatgccacat ggcagacttg aagtaatttt aaaatccttc tgtaaatgga gtgtgttgag 280380
agagcaagga aataccaaat tctagtgaac tctttgtgca tgctaagtac tttcttttca 280440
aaaccgcatt tgcttggtag gggcagtggg gggttcctag ttttcttagt aaactgtgat 280500
gttggtaacc tttcattatc tgggcacatg tttacaacac tggttttctg tcttcctggg 280560
tttagtgtcc tgcatgcccc aaagcctgtg ccatggagaa ctgttgcagt agagaaggca 280620
ggcaattttc aaagaatgca tgtttgcaca taaacagggt ctaggagtgg gtgtataaat 280680
gtgtgagtga taatcacagc agccattgga agtagtggtt cccatgctca gcagtccttg 280740
cagatgttac tcctggcatt cattcctgtg catgtcccat taactgcctc tcaaatctgc 280800
caccacttgc cagcagatgg cctttgcccc tgaagatgtt tcagactggc tgtaagggct 280860
ggggggaggg gggatcttgt acaagaagag aatgatgctg acactgaact cagagttagc 280920
agacctggat tttatgcaca atgctgttgt tagccatata accttgggtc ctctctacca 280980
tggggactca ttttatgatg gacaacttga gaaaattgag ttaaatcacc tccagtggtg 281040
gtttttaccc taagtgtctc aagttgcata aagtatcagc cttagatgag gccaattgaa 281100
cgtttatttt accttcttgg gttcctaaaa atcaatgatt tggcactacc tcatttacaa 281160
ctgtttttaa aacattgagc acagtcttag ggttaaaaga aaaaaagagt tattacatct 281220
ttcactacca tgaaaccctt tccacaagac cctcctgggc accatatgac aattcaaagg 281280
tatttatttg agactgtcct tagactatag ctttagctgt ttaaatttag ggtccacact 281340
cattggtcct tttgaaaata aacaggaacg atttttgaac ttgagttttc taaaaccacc 281400
tctgtgctca aatattggtt agagtctaag caaggagaaa gtgatccata tttcattcct 281460
aagcttctct gcttccttaa gtaggaattc ttgagttacc ttatcaaagc agccttccct 281520
gatctacata aaatagcatc caccccatcc ctctcagtcc tctagccttc tgtgtttttc 281580
ttttaagcac cttacatatt atatatttat ttgttaatca tcagtctcct caactagtct 281640
gcaagctctg caaaaggagg gatggtattc ttatccttat tctcattctt attcttccct 281700
ggtgaatgaa tagtacctaa aatactgctt gttcccataa tgggcagtca gtaaatattc 281760
attgagtgaa tgcctaaatg acattcacta agtgaatgcc tctcatgtgt gggcctgagc 281820
cattaggaaa aggaacatac atgctgttct gatgagaatg cttgaatctg atagcagttt 281880
aagggtgtgg ggaagggatg gagagtctag actattttcc ttagaagtgg atacttgatg 281940
tgtataaaga aatgtgagga gggaacaatt tgtgtaaaaa aaaaaaaatt ctagacctat 282000
cagtagagtt tggggatttt ctaatacttt ttttaaaagt ctgcactgtc tgtatttcct 282060
ctccttttcc atttgagtgg tttgctttgt cacttgtttg tgagcatcct gccctggctt 282120
tctgtgaacg gcggtggttt tgtctcttat catcacatca tttcatcact gcttacgttc 282180
atatttcttt tcaaagtagg gatgggcctg aagtgctgta tctccctaga aaggggctga 282240
ctgaataaca cttcattcta gtgcacacct tagaatgaaa aaatggtgtg ctggtacaaa 282300
tgaaacccat ttaatgtctc tgtggtgtgt gatgggaagt tcacaaaagc tttcttaggg 282360
aggcattgtg ctagttagct tttgaggaca gcaataataa aggtttctgg aattttgtgt 282420
gtctatggac tcccttttca gaataactgc tctgagtgca ggcattactt tattcctagg 282480
aagaaatgga gagactaaaa taaatacctc tgtacctgtg taaacagcat tatgctgtct 282540
gtgtaagtct taaaaaatgg gagctgaatt tctcttactc tgaatctcca gactaagaga 282600
attgcacaca cacgcacact ctaataagag caatctggga atttccctct gtgtctgtca 282660
gtttgtacct tttagatttg ccatctgtga taccaaattc tccagcgtta caaaaaaaaa 282720
atctgaagta gataagaggg tcaggagaga aggggagatt ccaccacttt tggacaagtg 282780
agggagaaca atctcctttt tcttaaatcc ttgcttgtaa tgctcctgca gattgaccta 282840
cagattgtaa aggcagagag gttatgactg agctcattcc atccaagtgc actggggata 282900
gcttcaagtc ttctagagtt ttctctttca cccatttctc tctcttcctc agacttcctt 282960
gaatggcttc tgattgacag cttcactagt tcctggccat tgcccctggt gtgttatttg 283020
ggatgggcac ctttggcagg gtctttgcag gagtcactgc ttctaagaag tggtgtcaga 283080
gctacctcct gaggcaactg acaaagcgta gcccatccca ggcacaccct ttcccctcag 283140
caccttcttc ctcaagtact cagctcctcc tctcagcatc ttggagagga ggaggaaaat 283200
gcaaagaaca cccagacgtt gtggaaggaa aaaagttcat ggatctttta caacatttgt 283260
gttctatggg gtgaaacaac atcaacagcc tggtcaggct gctttgtaac tgaatagtgc 283320
caaggtaaaa tgcttttgtg tcctctttaa gtttagagtt cactcaatta catgatattt 283380
attaaaagag tgttgtgtgc caggatgttc ttgagtctat cagggatcca gggctgagta 283440
atctgtactt actgcccttt gagactctag gaaggtgcta tgggaaggat gtacttggtg 283500
gcggagtcag gtgtaccgaa agggacgatg ggtaagagtt gtcagcgctg gaatttcagg 283560
gaagacatct aaattgagcc ttcaagcaga ggtggaattt caacccaata tatatgtgta 283620
tttagagaag acaaaggatg ctttgagaag agactaggaa tagtatttta tgtactactt 283680
ctgtgtctgg gcatgtgaga gctcagagcc agagctttcc ttccatcaga aattgtttgg 283740
tttgaacact gacaaaaaca tagcatgagg atttgtagca catggccacc aggccaccat 283800
tttcttcagg atcattttag atattttttt tttttttttt ttttttgcag atgaagtctc 283860
ttgctgtgtt gcccaggctg gagggcagtg gcacgatctt aactcactgc aacctccacc 283920
ttctgggttc aagcgattct cctgcctcag cctcccaagt agctgggatt acaggtgtgc 283980
ctcacaatgc ccggctaatt tttgtatttt ttgtagagac aaggtttcac catgttggcc 284040
aggctgatct caaactcttg agctcaagtg atctgcccac ctcggcttcc caaaatgctg 284100
ggattatagg catcagccac tacgcctggc acattttgga tctttatatg taaaagttga 284160
agcaagaact tgggatgcct aaagaatgat gcctcccagc attagtaagg gcagtgtttc 284220
caactgaact ttgtacagaa aaacccaaac aaaactaaag atgtattttt taggtggtat 284280
aaattcgaag tgctcaatgt tcaagaatcc acaataaaga agggcaggga tgactgaata 284340
gtgataagaa ctagttgaca ttgtttagtc atagaaccca aacaaaatct attggttctt 284400
aacaacacat aaattactcc ttaggactaa tgtaaacaga caaatagaaa ggtaacttca 284460
ttttttaatt atctaaattt ttcacttttg taaaagaatc atattatacc ataaaaatat 284520
taaccatgtc tccaacttaa attcatgtta aatttccagt ggtagctatg taataaatta 284580
ttgctaagta gaattgtaga ctgaaagaat taatccatct tctataaatc ctgaagatta 284640
tgttaacctt ttccagacac ctaaacaagt atgttacatg attcagaaaa agtcattttt 284700
gacaagtata aaatgatttt gaggtgtgat agcaaattag ctgtttcaaa cctatgttag 284760
agaaattaag ttttcagagc aatttttttt tgtatttgtg cttatattcc tgaaacaact 284820
tgcttaagga gagtctcctt aaatggaaac ataaatggta tacaaatggc tatcctctat 284880
cataatcttt tatttccaaa actcagacag gtttttatca tcatgctctt tggactctta 284940
accatcttct tctactttta aattctactt ctttctcaat acatttttaa acagcatctt 285000
gtgatcattt cccagtcttg agtgcctggc actgggaggt gacctgccca cattgctgtc 285060
agaattcgct gctggacccc tgcacaggtc ccaggctgtt ggttacgtgt ttcaatctgc 285120
acatcagcca tcctcaccag ccttcctttg tgcatctgga aataaaaatg ctcttgataa 285180
aatggttttc taaagtttcc attaggttgc tcttcatttc atttttcctt tcttcttccc 285240
aagcctttgt ggcttgcata gaattgaaaa aaaaaatgta atttctccag ggctaaaatc 285300
caagactttg ataggcagtc ttaatgcatg gggctcctac gagttgctac ccgttataag 285360
cattgtaaaa ctcaccctgc agaacaaaga gaactgggca caaagattat tctcttcttc 285420
aaccatggca agccctagtt ttccggtttc ctttgccttt tccttctttg atctctaaaa 285480
gaaggtagaa gagtagaacg ctattgttca gaaaggagaa agctattgct tgtccaaaca 285540
gattgttttt tccttctgtt tggcaacctc aatggctcta cctgtttctg gctgtcatac 285600
ttcggcttgt gaacagcctt cctccctaat tttcaggaaa ctaacaaatt aaaggtgcaa 285660
atgtcaggtg gttactacat atctactggc tcacataatt caaaacagag tcatgcagct 285720
cctatctaaa gctagttcct tgccccttct cagtcactac cacatcaagc acaaatgtag 285780
atgaaagggt agtgtgtcaa ggtgagagct gcccactggg tagtgttact cggtcacttg 285840
ctatagggga cagattagct gccaatcagt atctcatcac tgtcattggc gtttataatc 285900
caggttccta gccccactgg tgatctattt ctgtgcctcc gcagtgacgc cagttgtcct 285960
agcaacgtgc tggctggcac ttcgttaaag gcaagtaagg gagtggtggt ggaagagggt 286020
ggcctcgaga gggtcagaag ggagttggca gtcaccttgc tcaaagagga ttttccattt 286080
ccctcatctg ggcaggcctc caggaggaaa acgtcactta ctaagtgtat catgggagtg 286140
tcacttacta aggatcatgg accacatggt ctttctggta cagatagaat cccacggaga 286200
ataacaaatg aattaatggg tagtccaggc agaatgtggg gactgccggg ccaagatgtt 286260
aggcgatctc aaagcatctg atggtatcag tttttcttgt gaattaggtt aatgttttgc 286320
ttgtttatca gcactggcat gcagagttgg agacatgagt agatgtttgg gaggaatcag 286380
aggtcaaggg aggcagaagg aagggaaaca ccatgacagt ccctcttggc cccttttcct 286440
gttgacaggt ctggcctgaa agccatccag tgtaacgaga gccttcttac tgagctctgg 286500
taatttatcc atgcacccag ccttgaagag gaatatggct cactttgtaa tcttcttaat 286560
tgctctcctc tcattatgcc acattgaatt ggcactaaat gactttttct gccattttcc 286620
gatttggatc caaagaacat agaaatactg tggattgtat cttaaagtcc ctgtccaaag 286680
tggccttgcc tagatgaaat ctaaaatgga cagtcaagtg acattggcag agctgggggc 286740
ttccctccat ggccacttct ctgtggaagc ccctaggcaa tgggtttggg tgacattttc 286800
tcctgagagt gcttcgtctg tgtggccctg gagatgccaa gacatttttc acgaagaaag 286860
agactcaagg tgggtctttg caaggaaatg gggaacaagg gagactgatg aaagggtgtc 286920
cccagagcat tgaagaccca cagatgacag gaagtatgac gtatgcattg ttgcctttcc 286980
cttcacgact aaaagagttt ttgtagtctc aatgaccgtt gtcatttgtt ccactgaatg 287040
accacactca agtcgagata attgcatgaa actgtgtgct tatgatggga aagacattta 287100
gggtgtaact gaccatttct agcacgtttt gtatactcaa cagaaggtat attcactcct 287160
tctaccatag ctgaaataag ggctggtagt gaagatctgg gactggaatt gaaagaaata 287220
atttttggaa aaagaaaaac tccaagggta gctgttggca ctttcagagc atcccatatt 287280
ttcaggatgt tttgtatgag ataaagtaaa tcagttttgt ttgacagggt gtagtgtgcc 287340
cagccaggtc attattttaa attgacaaaa tgatttaaat gatagaagac attgtatatt 287400
cctgaaacaa taaataccta ttaagtacat tttgatacag tggagaagta cagtttttgt 287460
tttttgtttt tttttttgga ttattatata actgttaatt caacacttag tgtttaaata 287520
ctcatcattc tttatagtgc acaggtcata aagatagttc tctcatatga ataagaaata 287580
caactaatgt gaatggcatt aaagttagaa gcttcaaatt cttctctggg tttgatggtt 287640
gcttttttag aagaaatttg gtaaagtaga tgatagacca gttaggtttc atgaacttcg 287700
tgcttcatat tcttttcttt tcacaaccta gctagataca cagtaaataa ctggaagcat 287760
actagagtag aaagaaccct tcttcctgaa taagttgtcg ttgatcacag gggtaggcgt 287820
taatcaaaat attaatgact aggccaggca cagtaattcc agcactttgg gaagccaagg 287880
cgggtggatc acctgaggtc aggagttcaa gaccagcctg gccaacatgg tgaaacctta 287940
tctctactaa aaatatatat aaaattagct gggcatggtg gtgcatgcct gtagtcccag 288000
ctactcggga ggctgaggca ggagaatcac ttggacccgg gaggtggagg ttgcagtgag 288060
ccaagatcat gccactgcac tccagtctgg gtaacagagt gagactccat ctcaaaaaaa 288120
aaaaaaaaag taatgactaa ggagaagata gggacacctt gggctctgtc cagtagcagg 288180
aacctcaggc taagaaggga cacctgggtt ctcttcccat ccctgccctt ttagaccagt 288240
ggcaagctac tctctatctg ggtgcctcta tttccttatc ttccaaagga agatcattat 288300
cactgccact taacagcatc agatttaaag tattagttca tataagagac tctttgaatc 288360
acatttgggt tcagatttca gacctgccac ccagtagctg tgtgtccttt gggaaattgc 288420
ccaacttctc tgagccttat ttacttcatc tataaagaag gtctgaccac acctaccctg 288480
atgacctgtt aagagagtta aatgcgataa agtctgttaa gtttttagcc cagtgattgc 288540
tccctaataa ctgtggcagc catgatgctg ttatgataaa tttcacacaa caaaatctat 288600
catgatgcgt tgctgaagtg aacaggtgag cagttgcaac ttgctcatct ctttgttgta 288660
gagacatttc tgctataata ggagttgtca ttaactgtca ttgtcattac actgacagtg 288720
aattcggtta tgtattgtta agaccttctg cttccttgac atgtatatag tagaataatt 288780
atgacagtga aggtgacaca tttgtcagaa ttatccatgt gcatatgctg agggcccttg 288840
gaattttagg tgaattttat agtattagtc aaactgaaag gcacagtgag tttggaaact 288900
ataatagtct catctataaa aggagtaggg agattcccaa aggctgttga tatgagtaga 288960
actctgaaaa agtaaaacat taaaatacat tttgatgtgg ttaccgtgtc taggtggtga 289020
taggtaaaaa cagtctagtc taattctttg aaatttagga tagaagaaag cctgaagatg 289080
gatatctaca ttcttgtatc ttctttcagc aaatatttac agaaagagag agagagtgtg 289140
tgtgtgtgtg tgtgtgtgtg tgtgtatgca cacacatatg ctacaggcta ggcacctaca 289200
gtagttaaag gagctttcag tcactgggga aagaaatgag aaaacaggca attcctttac 289260
accatgacca gctctctcct aatggtaccc acaggttgcc atggatgcag accagcatgg 289320
catcttctgg gatcagggaa gctttcatcc tcagacttga atgaggagta gatgttaacc 289380
agaaaacaaa gtggatgtat cagttagcat atactgtgta acaagccatc ccaacagtta 289440
agggccaaga ccacaatctt atgattgtgg gtcacctgga ctattttagt ctgggccagc 289500
ttggctggga ctggttaatc cagcatggtc tcactcacat agctactaga aggctggttt 289560
gcctgagaga tgggtgatct tcagctggga cagcttgtct ctgcttcagg tggcctctca 289620
tcctccagta gactagtctg agcttcttca ctttgcaggc taagggttcc caaaagcagc 289680
aagaaagggc aagccccagt gcatgagtgc ttttcaagct ctgcttcaag atgcttgcta 289740
atttcccttt aaccaaagca aattacttaa tttgttcagt tcaaaggatg gggaaactcc 289800
agctctagtc acatgaggac aacatgagca aagctcaaag gtaagagaga acatggcatg 289860
ttggaagaca gcaagtagtt tggagtggct ggagtcaggc atatgtgaag tctcatgaag 289920
aaaaagccag atcataaagt gtcttttcag taagttctgc tgaggagttt agagtttatc 289980
ttgaagacag gggagtggtc attgaaagag tttaagcagg atgttgacat gatcaatgag 290040
atgtgtagag acatggttag gtggtagaag cctaaaaaca ctcgttagcc tagacaattc 290100
aggaagtttc caaagagatg acccagggat agcataggag aagatggaag gacttgactg 290160
agaggtggct caaagctgac gtgtactttc agaacaatgt gaccagaaaa gaggttggag 290220
gcccttcaag gtagagcaga aaagacagag gctcaggtca tcagcaatat ccgtatgaat 290280
ctggtgggag aactccacca gtgttcctca cctcgctcct ttgtgggatc ctgccagact 290340
ccaatgtcct tgggttctaa ataaacacct accaaggggc tgagtcaaag agattccagt 290400
ctctggaagt gtcttcttgt cattgtcatc acccagccaa agactctttt ccttccaaca 290460
tgtttttccc tttgacctca aaataaacaa tgtgttctaa aggctctggg gcactctcaa 290520
aatgcttctc tgacctcgga taggaccatg cttacccatt aatttccaga tctgaccttt 290580
tcactacacc tttaagcata actctttcaa aaggcaaaaa tagaaatgac tgtttcattt 290640
caccaaattc aagtcgccaa gagtgagaac gtgtggtttt caccggtacg tttggggacc 290700
agtttgttgt cactgaaact gcctgatatc gggtcggagt ggctgggtat ttttcagtcc 290760
ttggggttat aactcaaatg ttggaagtgg tatcttttat aggtaaaatt gagggagggg 290820
agcatcaaaa tgtgtgcgat gcagataata atttgccaag ttttctaatt tttttcatta 290880
aaaaagaaca tacagaagag tctacaagta gggcaggcag ccttcattcc tatgctcttt 290940
tccttgaggg acaccttccc taaccaaata attgaaaata aatgggaatt gtgggaacag 291000
aggaagacaa gaaggaaaac taaaaaccca ggacctaatc ttccaggggc aggcaggcca 291060
cttttgtagc tcagattctg accttttctc caatcaaaga gttcgaacag actgactgat 291120
tggagtgctc tgtcagcatt aaactcaatg cagggttctg ctctggcacc tttaggggtg 291180
gtggtttaga ccctctgcgt gccatgtctt atcaccagca ctgctaactg aatgggatgc 291240
attttcaaag acaggagagg gtttgaaaaa ccccagggca tgctcggagc ctgcaggcat 291300
ttgtttgctg ctgagaacca tggcaagcat ttttgacatt tttatcagag tcttagttaa 291360
acaattatgt ggaggactga taaagaagtg tgtgatagga gacttcataa tttaaagtgc 291420
ccaaatttgg tgagctttat actcatgtga aatggaaatg aaaacatggc atgttttgga 291480
attcctgatt ctgcttattt gctttaatag cagatcattg cataaacact gactcattgc 291540
attctatact gaaaggaaga tatggtttgc tgtgttcaat ctggtctggc ttccagaaca 291600
cagtatagaa caagtgccag aagaagggat gagctcagct ttataggtga ctggagagat 291660
acccaattcc atgttttgtg ctgtacaaac acatgacctt acatgaagtt ttgcataaaa 291720
tattgaaaca atacatttct ctttataaat atgtatgtaa tctgttctag agtgtatgga 291780
gtagacagta aaaaaaaata gaatcttctt atttttggaa gtggggtgaa gacgcaggtg 291840
tgcatatgct gccacctgcg tgttatttca ctgagttttg tcaggttctt ttcttactca 291900
tctgcacttt gtatgttacc ttaagcgctg taaccattct aagctgccag ggacatgggt 291960
atgcaatcaa agtcaacact gtgattaaaa ccacctcctg ttgtttacct ttttagaaat 292020
tttaataata cagtcaagtc tgaaagagca gaacttttct caaagctaca cacttggttg 292080
cctcttcttg attaatgcat gggggtggtc actgtaacct aaggtctgac agatggtgcg 292140
gagattgatg aagttaaggc ctgttaggta ttccgagtgt cttataaaga aaaataggct 292200
accttaattc aaattgttgt tgctcttcca accttctctt atgtaaactc cctgtatatt 292260
acaatgacag actctctctc tttctgtctc acacacacac acacacacac acgcatgcat 292320
gcacacatac gcacactcct gacatgctct actgaaagct gcccagctac agagaggtgc 292380
gaatctaatc cagggcacat ggctgctttg catttcactg gctgtctagt gtcactctat 292440
gatataggca taaggtcatg actgtgagct atcattgtca cttatcttaa tattaaaacc 292500
cctctgatcc aatctgtctg ccttatctat tacatcattc acatatctag attcttcaaa 292560
cttaactact cattgcagca aactcaggaa tgccgagctc taaggcatct ccatttactt 292620
cgttcatctc aatctcaaat tactaaccat agttcagttt caggatgaca ctgaaaattc 292680
aaaattactt cctgtgatta acttacattg tgatggttgg gaattatttc gcagaagacc 292740
tgttcatctt ctgatgaagc ccttttcaag ttttgaattg tgtgtgtgtg tgtgtgtgtg 292800
tgtgtgtgtt ttaattgcca gaagtctttc agatagcagg gagattattg gaatgagaaa 292860
gcaaagcttg tatgaaaact tgtggcaaaa ggtcatctgt gctgtggggg aaatttcaaa 292920
gtaggcgcag tttgtttcca gtggttcctg cctgtccttt cagtggctgg tcactctctg 292980
ttccctttcc agacgaatct ttcccctctt ccaaatgcct cacatcagtc taggtacctt 293040
ggttggcctg tggagaaaaa cagtcttgtt gagacactca cattaagctg atagagacct 293100
tggctaggat aattgcattt ttcaaaggct aagggttgga aggatttaat ttttctctta 293160
attatttttt atagagatga agtctcacta tgttgcccag gctggactca cactccctgg 293220
cctcaagtga tcctcctgtc ttgacctccc aaagtgctga aattacaagc atggcctgaa 293280
tttttttaat ggtgatttca gctgatccca ggggagatct tttgggtgtc atttttcaaa 293340
cagattagga agcaagcagc tgtctaccta atcagtctaa actacccatt ctgacttctg 293400
tccaataact ttccatataa aatagctaac ataataataa tcagataact ttgcatgtaa 293460
gtttcaaagc tatggtatag ttcaccaaca taattttcca gtttttttta ttatagtaaa 293520
gtacacataa cataaaattt actgtcttag ccatttttaa gtgtatagtt gtacattcat 293580
attgatgtga agccatctcc attgtcttgt cttcacacct ctttttttct ggcaaaactg 293640
aatctagacc cataaaatac taatgctcta ccctccaccc tagcccccgg cagccaccat 293700
tctacttgct gtctattatt ttgactactg taagtggctc atataagtgg aatcatgtag 293760
tatttgtcct tttgtgcctg gctcatttca ctgagcataa tgtccttcag gtctgtctgt 293820
gctatagcat gtcagaattt ccttcctttt tagactgaat aatattctgt tgtatgtgta 293880
gaccacattt agcttatcct tcatctatca gtgggcactt gggttgcttc cacctttagt 293940
ttattgttaa taatgctgct atggatatga gtgtgcaaat atctctttga aactctttga 294000
aaccattcat caactctctc tttttctttt tttttttttt gagacagagt tttgctcttg 294060
ttgcccaggc tggagtgcag tggtgtgatc tcggctcaaa acctctgcct cccaggttca 294120
agcaattctg ttgcctcagc ctcccaagta gctgggatta caggtgcccg ccaccacacc 294180
aggctaattt tgtattttta gtagggtcag ggttttgcca tgttggtcag gctggtctca 294240
aattcctgac ctcaggtgat ctgcctgcct cggcctccca aagcactggg attacaggca 294300
tgagccaccg cacccagtct tcaccaactc tctttcacgt ctttattaga tacaagtgtt 294360
tgaagaagcc ttgcatctac ccactttgaa ccttttttca tgatagaact gtaggtagac 294420
tttctgccta gtagtgttat ttgaagcatc ctttctgctg acctctttcc tgaggcctga 294480
aatgctacta atagtagttc agtcctcaag tatcaagcaa agccatcagc tagttttcta 294540
ttaaaatgca aatgatcctg gggcagaggc cacagataag atattagcac cttggtgtga 294600
atttgtttaa ttagatccta tcttagaagc tttctttaac cccttgccta gttcttcact 294660
aattgctccc tgataaggtc ttgcattatt actgcaagta tcacactgta ttaaacttat 294720
ttatattttt gcttctcctg atagaataga agcttcttaa gggcaagact cttgtataat 294780
tgctgttggt ttttcaggcc ctaatagaat gtcacagaca actttcaata agctactcac 294840
tcattctttc atgcattcat tcattcattt cactcattta ttcatcaagc atttattggg 294900
tgcccacggt gtaagtgcat tttaaaactc tgcctttcta gaaggtttgg acagccaagg 294960
gccagctctg ttgcacagtt ttggcagatt ttagaaacct taaaatctaa cttcctgtat 295020
ttttaggtgc agggacttgg tccagatgag tggatcaacc tctgaaatag ttttctatca 295080
cagtcctacc tttttttttt ttctgcttct attcagaaga agcatcgatc taagtaagtt 295140
tgtgttctgt tcaaaagtaa ggtgatgttt caatgtatat tctcaagcat ctgaaaactt 295200
ctctagttgc tctaaatctc aatatttcca atatcagcca tgtacagttt ttaaatgctt 295260
gcattctctt aggacattgt taacaatctg cttagaaagg ggagtgactt ttgcctcttt 295320
tggctaattt gctttgcatt gatttgtaac tgtgtacttc agtatatacc agcaactcct 295380
agcccaggga tagcatatac tcgcttactg gttccagtga ctgttcattc atcccacagt 295440
ggcttccctg gaaacaagtt actctgataa caatttgatg gtacttccct ttataaggta 295500
ataaccagtc cgggccaggc atggtggctc acgcctgtaa tcccagcact ttaggaggcc 295560
gaggcgggca gatcacgatg tcaggaaatc aagaccatcc tgactaacac agtgaaaccc 295620
cgtctctact aaaaatacaa aaaccaaatt agccacgcgt ggtggcatgc gcctgtagtc 295680
ccagctactc aggaggctga ggcgggagaa tggcgtgaac ctgggaagtg gagcttgcag 295740
tgagccaaga tcgtgccact gcactccagc ctgggcgaca gagtgagact ccgtctcaaa 295800
ataaaataaa ataaaaataa aaataataat aaaaaccagt cctaaaccaa attcttactt 295860
tagtctctag cctcagagtt tattagttct tagtaatgtt actatgaagg caaataggag 295920
acaaattatt attctggttt ttattgttac tgccactgca attcctatga ttattgctat 295980
aattccctat ttaataggta aacaagttac aacatattcg atggtcacta gatagaaata 296040
gaaatggaat gtctttacca agagaatatc cgtgttttac agagaacagg aaacaagtac 296100
taaatggaat cttcagacaa tcttttggtc ttcttgtagg cagtggttca gcttttttac 296160
ctactaaaat tttggacagg gttgttaaca ggcaatacag tttaaaatga actgttttaa 296220
gttttccttt ctgacttttt catactccta cattaatgca ataggattga aggctacaac 296280
aatgataatt gcaatatgct gaaataatga actacagtaa atagctatag tgaatgtatg 296340
cccatagaaa agaatggaaa acaaatggct tttgattaaa ggtacttatt gtaacagatt 296400
tcaaggtgaa attgttagtt cagaaaagat ggtagataga gtctttaaaa atactgtcac 296460
tgggatgcgt gttcttctat aatgctccct ccatccccca cccgaagaaa cacacactcc 296520
tccctcctct gcatgtaaag cagtagtttt gacaaataaa accaaacagt aaaacctgac 296580
actggtgatt ggaccgtgcg tccctctggt ttgtggatga ggagcatatc tccgtgatag 296640
aataaccacg cttcatgcta actcccggcc acatcgctgc atcctcttca tacataattt 296700
gcatcatggg gtgtttctgc atatgttgtg cattttgatg ttatttttag ctacaatttt 296760
taaaacaata acattttttt aaatagacta atcaagaaag cgcctccaga gtcaagaaaa 296820
caagtgctgg ggatgtgtgg gtgggggtct gtctccccgc ccagggcatt tccctttgct 296880
gctgttgtta ctactccttc cattactttt tgtgacttta gctttttgaa atttccattc 296940
ctttgttttc ccttgtgcat caggatgtgg ctgttgaagt catttatgtt atgcgaggct 297000
gcaccacagt catttaatgc aaacactggc ttttgtgtaa ggcactgact attctaccct 297060
cagcgaggaa gacgttattg gaaacttgag ttatgagatg gaaagaacat taatcctttc 297120
attgaaaaca ttagtctttt acatggattc tctgtaatag cttgaagaga aattaaggaa 297180
atacaaacta gtaatattaa aaatctgcca tgtcattatt atctacctgc ccatagatgt 297240
tcaccaccgt tagcatttga gtgtgttttc ttccagaaga ttttctatgg atatatatat 297300
atacaaataa atacatgtag ctttacagaa atagaatcgt gcttgatcta cttttccgaa 297360
atttcttctc tcacattgca aaagttgtga atgtctttcc atctgaatta ttacagattt 297420
tcaaaatatt tttctggcta ctgacttttc cagtatatga atgtaagagt gaaagttctt 297480
cgatttcacc agttggatat gccccctttt ctcttttctg ccaatatcaa ttgtactgcc 297540
ctcttgcgct atcctaaata tgatcagatg agaattctga aagagaagaa atctaggaac 297600
cctacttgat agagagttat cctcttgggt tccctcctga catttaggcc tttttttttt 297660
tttttttttt tttttttttt tttgagatgg ggtctgactc tgtcacccag actggagtgc 297720
agtggcgcaa tctcggctca ctgcaatctc tgcccccgcc tgggtacaag cgattctcct 297780
gcctcagcct ccctagtagc tgggattaca ggcacctgcc actgcgccca gctaattttt 297840
gtatttttag tagagatggg gtttcactgt gttagccagg atgttctcga tctcctgacc 297900
ttgtggtcca cccgccttgg cctcccaaag tgctgggatt acaggcatga gccaccgcgc 297960
ctggccacat ttagtacttt taagaagtta ttcctcttcc atctcagctt cctggacaca 298020
gttcgctatg acttttcttg gaaattatgc attcccttag aatccttgta ttttctgttt 298080
actttccctc aaagcaagga ctcatgacct cacctgtagt gggcctcccc atctctcatg 298140
tctttatgtg gcccggactt agcagagaca cctcttggta catcattttg attgcatcat 298200
gagctttccc agagtctgga gtgactctgt ctttcagatt tcattttaac ctcctaatca 298260
caggctatct ttgatgcacc tatctttacc tccagttctt ctgctaaaga actggaggct 298320
tgtggctctt gtcttccggt caaacatgat gctctgctga ctactcttcc ccatgcattc 298380
atcccacccc agaccctgcc cttgccctca tccccatctg aatcattgca tcctcctagt 298440
tcttggccaa aaaactggct ctcctctagc ccttcaaacc ttgcctggga gtcatcttta 298500
tggcaccttc cctgattttt tgttttgttt tgttttgttt ttggaaatgg aatttcactc 298560
ttgtcaccca ggctggagtg cagtggcacg atcttggctc acggcaacct ccgtctcctg 298620
ggttcaagca attctcctgc ctcagcctcc caagtagctg ggactacaga cacctgccac 298680
catgcccagc taatttttct atttttagta gagacggggt ttcaccatgt tggccaggct 298740
ggtctcctgc cctttggtga tcaacctgcc ttggcctccc aaagtgctgg gattacaggc 298800
atcagctacc acacccagcc gttgcacctt gcctgattaa ttccacttgg ctctagctag 298860
tatctggaag gacacctggg aggaacactt caaacagctg tcagtgcagt gttgttgttg 298920
tttttgtttt ttaattaata ggctttttta tagaacagtt ttaggtttac agaaaaattg 298980
atttgaaagt acaaagagtt cctatattcc tagcctcccc gacccctgac aaacagtgtc 299040
cctactgcta acatcttgca tcttacattt gttgaaattg aactaatatg gatacattat 299100
tattaactaa agtctatagt tcatgttaga gttcattctt cctgttgtac attctgtgtt 299160
tgacaaatag atgacatgtg tcctaacaac tctttgtgct ctgcttattt gttcctccca 299220
atccccaaaa cccctgattt tttttttttt ttttactatc cctgtagctt tgccttttcc 299280
aaaatgtcat aaagttggaa tcatacagta tgtacccttt tcacattggc ttctttcatg 299340
tggcaatatg cgtgtaagtt tcctctatgt ctttttgtgt ctggagttgg ttcctaccgg 299400
tgggtttatg gtctcgctga cttcaagaat ggagctgcgg accttcatgg tgagtgttac 299460
agctcttaaa gatggcatgg acccaaagag tgagcagtag caaggtttat tgtgaagagc 299520
aaaaggacaa agcttccaca gcgtggaagg ggacccaagt gggttgctgc tgctggctgt 299580
ggtggccagc ttttattccc ttatttgtcc ctgcccatgt tccatttctg ttctgtcaga 299640
gtgccctttt tttcaatcct ccctgcgatt ggctaccttt agaatcctgc tgattgatgc 299700
attttacaga gcactaattg gtgcgtttta cagagcactt attggtgcat tttacaaagt 299760
gctgattggt gcattttacg aacctcttgt aagacaggaa agttcctgat tggtgcattt 299820
tacatcctct tgtaagacag gaaagttcct caagtcccta cttgacccag gaagtccagc 299880
tggcctcacc tctcaatccc ccctctaaac aggacacccc agctgctgtt gggaactggg 299940
tgatgactgc tctagctact tcctgctgga taggggtgaa gaaggggccc tgcagttgta 300000
gtgccctcca gaggggaaca ctctaggcca aagggctggt gggtcagtcc aggggtcctt 300060
ggtagaagtt gtgagttgag ctcatttggg gttccatttg taagaccatc tgtagcttga 300120
tggtatcgat cctggaggaa acaaatttga caaagaggtt aaaaacacag ggcccgaagg 300180
tgagtaatag caagatggct gtcatgggac gtagaaaggg gagaaaccat gttgcccaac 300240
tctagaggtt ggtataagag tttgaaaggc attgtctgat ttcagaagcc ttttcctgta 300300
actgctgggc agcatcttgt actatccctg agtggttagt gtaaaaacaa cagtcttctc 300360
ctaagaaggt gcagagtctt cctttctcag cagtgaggag gtctaggcct tggcggtttt 300420
ggatattcac tactgccaaa gagtctattt gggattgcag agtaaggata gattttgtta 300480
tttcttgcaa actgtcttga gaaatccttt gagagtgtgt ggtagtagga taatgaagta 300540
gataaactgg ctattctggt tcctgtagca gtggctattc ttaaccgtat aagtaggggt 300600
attagttgta tggccctgta ctgacggacc tgagctttga ggggcactga tagggtctga 300660
tttcctgcgg taatgttaat gttgggactt aggaagacta aggtacaggt gcctgtccag 300720
ttagtgggga ggcagatgta agttgaagtt ccacataaga atatgccttg gctgggtaga 300780
cagaactggt tgtgtatgtt aaaaaggtgt gtgagtttgt tgttttcatt ttcccatact 300840
cctagagtac ttgccaaggt agtctggtga gtggctggaa aggggtgttg ggagcaaact 300900
gagtgactcc ctgtgctcta ttttcccatt ggagaaaaaa ctgttttgta tctactagga 300960
accattcaag agagtgattg aaagagagga tgagaaggta ttccttagtg gtgggggtgc 301020
tgctgcaggg ggtccagggg tgaatagtca tacagggagt atgtttgcca ttacaaaacc 301080
tggactgttt gttaagcagg gaggaggtga tgatttttgg gggccctgag aagcggacaa 301140
gccatctgaa tagagcggtt tgggtgcctt ggaagttact atgatcattt ggggcttgaa 301200
gttggagagt gtaattacac tgatgggata gtaggtgccc caggggcagg cctgataaca 301260
ggttgcgttg gatgcataac ggggcttgga aagttaagat ggtattcacg gttacagggc 301320
ttttcattgc tcatgtaata ggtgaggttg gaaatgtaag agcgtaaaag ctggattgca 301380
tgtaaaaaag gttgatgtga ttaggatttt tgtcccggca ggagctacag tatatagtcc 301440
tgctgcaaag agaatggtta gtatactgct taataatgtg atgaaactgt aaaaggattc 301500
cattaaaggg gcaaggagtg gtgttaaaga ttatgtaggt tttcacttat cctttttaaa 301560
taggaaagag tttttcctta ggatcagcta taggggcctt tttagtctgg gatgtttcct 301620
tctgaaatag gagacacaaa tcttccaatg gttcacaggt ttatcgaggc tggtctggct 301680
gatcttggga ctcctgagct gatggtccta caggttcttc agggggtgtc caaagtttaa 301740
ctcgcatgta gtgaatccaa gattccactc ctgccacctt aactgcagtg ggggtagaga 301800
ggattactga gtatggtcct tcccacaagg aatccataga tgaggaggaa gaggggaggg 301860
acttgaccaa cagtaaatct cctggttgga acaactctgt tcccttgtct ctgtgacatc 301920
ctttgggtag gtttttaacg ttttgttggt attttgccaa agaagttata tctttgacca 301980
acttggccgt ttcctgatca agtaggaggt catttgtgag aaaaggtcat ccatacagca 302040
cttcatatgg actgagcccc attttgtgag gagaattttg gattctcaac aaggccatgg 302100
gcaagagagt aggccatggg agatgagttt cttgtgttcg tttccttaag tgcctcttga 302160
gtgtttcgtt tgccttctca gccttccctg aggattgtgg cctccaggca cagtgaaagt 302220
gatattgtat ccctagtgcc ctggaaattc cctgagttac cgtggcttta agagccggac 302280
cattgtcgtt ttgtaagctt tggggaagcc caaatctggg aattatttca tgagttagta 302340
ctttaaccac ttcctgagcc ttctccgtct tgcaggggaa ggcttctatc caatttggtt 302400
ggtcaacaca gaccaacaag tattgaaatc cccttgactt aggcatatgg gtgaagtcta 302460
actgccagtc ctctccagga tagtgaccta ttctttgttc cccaaaaggg gccttacgat 302520
ggaccaagag atttttcctt tggcacacct cacaggcttt gactacttgt tggatggtct 302580
ggaggagata tggccccata aatagggatt tggccatttg atgagtgttc tcaaacccat 302640
gtgaaaagtt tggcaggggg tcttaagtat tttccactgg ctggcttcgg atatgagtac 302700
ctttccctct tctgccgtta accaccccaa ggggagaaaa ctatgccccc gtgaaagtcc 302760
ccattctgtt tcgatcaggg agtactgggg cttaatctct tggagggggt tgttccatac 302820
catgggtcct tccataggta tttctaatgg gaggttctgc ctggcagcaa ttttggcctc 302880
agcatctgcc cagtggtttc cttctgcctt ttctccttca cctttttgat ggcttcagca 302940
gtgtaacact gccacctcct tgggtttttg cactgtgtgc aataactcca taatttcctt 303000
gtggtattta atgggggttc ccccagaggt taggaactcc ctttctttcc atattgcagc 303060
atgggcatgt aggattagat aagcatactt gctatctgta tacacattta ttcttttttc 303120
ctttcccggt tctaaggctt gggtaagttc tgctaactag gcgctggtcc gtggggggaa 303180
gagacttact ttcaagtact gttacatcac taactatggc ataacctgcc cttcatatcc 303240
cattctccac aaatgaactt ccatcggtat ataggttaag gtcaggatta gctaagggta 303300
cttctaagag atcctgttgg gaagcataag tctgggctac aatttgttgg cagtcatact 303360
cgattggttc tccatcctct gggagaaaag tagcagggtt gagggctgca cacgtgtgta 303420
tttcaagcac cagtccctga atgagtagcg cctggtacct gagtaggtgg ttttctgata 303480
gccataaatt tcctttggca cctggtatgc catttacatc atgagtagtc tagatggtga 303540
gatcctttcc ttgtattatt ttgatagcct ctgacactaa gatagccact gccacaacta 303600
cccgtaaaca gtgaggccag ccttttgcta ctacatcaat ttccttactt aggttgtggg 303660
gttccttcct tactggttgt ggggttgtcc tacaagtctg agtaaggact ccaagagcta 303720
ttcccgctct ctctgtgagg tataaagaga agttttgtcc tggggaaggc ttaagtcttg 303780
agtttgtact agggcctgct ttaaggtttt gaaggctgtt tctgcctctg gttcccattc 303840
tactagatga atatttgccc tctcggtctc cttgattaga gtatagagtg gcctggccat 303900
ctcgctgtat ccggggatcc atagtcggta aaagccagtg atcccaagga acccccacaa 303960
ctgttttaat gtgttagggc aaggacaagc cagtataggc tgtatttgtt ctttgctgag 304020
ggccctggtt cctctggcta ggattaggct tagatatttg acttgttgta ggcagagctg 304080
ggccttcgat ttagatgcct tgtacccttg attagctaga aagttcaaga gatctagagt 304140
agcctgctgg catgaagctt ccgaactggt agccaaaagt aaatcatcca catactgaag 304200
gaccagcatg cctggacttg agaagtggcc tagatcttgg gacagtgcct gaccaaacag 304260
atgagggcta tccctaaacc cttgaggcaa gaccgtccat gtaagttggg ttttgtggtc 304320
tgtgggatcc tcaaaggcaa agagaaactg ggagtccaag tgcagaggaa cgcagaaggc 304380
agcatccttg aggtccagaa cagtgaaacc attctgcttc ctttggtatt tgagagagca 304440
gggtataggg gttgggtaca accggatata gaggaattac ttcctcactg atgagtctag 304500
gatcttgcac tagtctccac tgacgattca gtttttgtac tcctagaatt ggggtgttgc 304560
aggggctact gcattttctt actaagcctc gaacttttaa atgtataaca atatcctgta 304620
atcctttatg agcttcaggc cttaagagat attgcctttg ataaggaaaa gtggtggggt 304680
cttatagcct gatttggact gggtgggcat tttttgcctt tccgaattgt ccttccaatg 304740
cccagacttc agggttgatt ccctcctcaa gtaggggaca acaaatgggt aacttgttcc 304800
ccatattcat atagttaatg gctccagctt tggctaatat gtccctccct aataagggtg 304860
tggggctttc aggcataaga aaagcatgtg aaaagagcaa agtctcccaa ttacaactga 304920
ggaggtggga gaaatacctg gttacaggct gtcccaggat tccttggatg gtaatggatc 304980
ttgaggacag ctgtctgggg caggagatta acactgagaa ggccatgcca gtgtccagga 305040
ggaagtcaat ttcctggccc tcaatggcta aacttgccca gggctcagtg agggtgatga 305100
catgagctgg tgcttgcacc aggcaccctc agtcctgttg ttggatcatc tggttggggg 305160
cttctggccc ggagaacctt tgtcctctgg ggcagtaccc cgtctagtga ttgccttggc 305220
atagtggaca tgggtgaggg agtagcttgt ttcttgttgg acagtctttt ttaaggtgtc 305280
cttgcaaacc acactgataa caagccctac tgggtgattg gcctgctcca ttttctgtcc 305340
tctctgaacc accaaggttt gtttgtctga gggccatgac tgaggctgcg gcctttctct 305400
tatctcgctt ttccttttct gcctgttcct cttggttcct attagagaac accgcggttg 305460
ccaggtttaa taatgcctcc agattttgtt cagggccaag ggctcgcttt tggagctttc 305520
tcctgatatc tcagctgatt gggtaataaa catcttttag gatcaattga ccctcgaggg 305580
agttgggtga caggggagta tattttctta aggcctccca tagctgcttg aggaaggcag 305640
taggattttc ttcctttccc tgagttatgg tggacatcat tgaataattc atgggctttt 305700
tcctaattct ccttagtcct tctggaatac aggtcaacag atgtttgcga ctccagttcc 305760
catgatctga gtctaggtcc cagtggggat ccataatggg gatggcttgc tgcccattag 305820
ggaatttgtc cctttcttcg gctgtcattt tgtcatttac ttgactaaga taccaggtat 305880
ctccaaattc tcgggctgca gctaaagctg cattcttttc attaaaggcc agggtttgat 305940
ctaacaatag catgacatct ctccaagtga ggtcgaaggt ttgccctgga ccctgtagga 306000
catctatata cctaccagga tcatctgaaa actttcccag gtctaccttg atctgcttta 306060
attcagagag agagaaggtc ccatgttggg ccaaattccc ctccccctac agcttaaagg 306120
agacataact gatagcctga ggggtttggt ggtcctttgg aaatttcttt gcttgtttcc 306180
ttctggatgg aggagattag aggaggctca tcattaatag gaaggggagc tgtagggagg 306240
ctaggatatg gaggtaatct gagaggtcct cctgtggaat gtaaatcgcc agctttgcat 306300
agttgtggat tatccttcag taaaaagaaa gcttggacat aaggtatttc actccatttc 306360
ccttccctct tacagaaaag gtcaacctgc agaatagtgt tgtaatttat acttccctca 306420
ggtgaccatt tttccctatt agagagataa tattaaggcc agaccgtagt gcagaaaaaa 306480
taagccgctt ctttttcagg gtttgcggga caaattggtc ccaatggctt aggatgcgtt 306540
tcaagggtga gcttgttgat gcctgggtgt ttcccatctg aaagaaaaaa ccgcctgcag 306600
tttttttttt ttttctcttc tccctgccca agaacccaca acagtccctg gatcctgctg 306660
ttcggaatag ctgtgctcac caaagcagca gcggaaacac tagttttcct cctagaccac 306720
aaaaaggact gaggaaggtc agatttagtg gcccttacca atggattctc aaaaacctgc 306780
acccttgcct ttcgtcttta gaccacaaag aggactgaga aaagtcagat ttagtggccc 306840
ttaccaatgc attcttgaaa acctgttaga gtcctaagtg ttttctcctg ttgttattag 306900
gaccttaccc ttgtactata aagataatat gcctcaaaat ggagtggagg gccataccct 306960
gagggaagga agggatctcc agggttggaa gagtgatgcg ttttgtcctc acttatcata 307020
tgaataggaa ggatataatt tctgagtctc ctcctatcct agctttggga atagcctttg 307080
ttaggtctgc tagtctgagg agggatccta aaattccaga tagtccccca caacagggct 307140
ttggacaaaa attatgtctt tctgattggt gagcctgggt gcctaaagaa gggagcagag 307200
tcctgaaatt tatattagaa atcatcctta taggagaaac tggaagagca ccagggacag 307260
ggagtggttt ttagaagcaa gactaacctt ggagaagaga ggcgggagaa agtttgtctg 307320
acaggtgtta ggacccagga ggcaagggtc aggatagata ggatagatgg gtgagtcttg 307380
tttgggctat gtaactttga gagttctgct catggctgca gggccaacca actttttgtt 307440
gagaccccgg agctgaatgg ctttcctctc tgtcgaccct aggcttagcc cggaagtgca 307500
ggaaaagcag aagctggttc caggcaaacc aatgctcctg actccaaaca gtcgggggtt 307560
gttagtgagc cctttcccag agagcctgac atccatgtcc ttagtcctgt ggccatgcta 307620
gttgctttta actggctgac aggtgcctag ttttagcccc tgaattctaa ggaaaaatag 307680
gacagaatag caagcaaaag gggtctgatg gtactcacca cgttgcaata tctgggagga 307740
tcccccaaga tgtgtccaga gttggttcca gccggtggat tcatggtctc gctgacttca 307800
agaatggagg cacggacctt cacggtgagt gttacagctc ttaaagatgg cacagaccca 307860
aagagtgagc agtagcaagg ttaactgtga agagcgacag gacaaagctt ccccagcgtg 307920
gaaggggacc caaatgggtt gccactgctg gctggggtgg cccgctttta ttcccttatt 307980
tgtcccctcc catattctgt ttctgtccta tcagagtgcc atttttttca atcctccctg 308040
cgattggcta cttttatact cctgctgatt ggtgcatttt acagagcgtt gattggtgca 308100
ttttacagag cgttgattgg tgcattttac caagtgctga ttggtgcgct ttacaaacct 308160
cttataagac aggaaagttc ctgattggtg tgttttacaa tccttttgta ggacgggaaa 308220
tttccccaag tccccactca acccaggaag tccagctggc ttcacctctc atttttatgg 308280
cctgaaagct tatttgtttt tagtgctgaa taatattcta ttgtatggat gtaccacagt 308340
tcatgtaccc attcacgatt atgaatgaag ctgctataaa catttgagtg caggtttttg 308400
tgtggactta agtttttagt ttatttgtgt agataccaag gagcatgctt gccacattgc 308460
atgttaagag tatgtttagc tttgtaggaa actgccaaac tgttttccca agtagcttac 308520
tatttgcatt cccacccgca atgacttgag agttcctatg gctctgcatc cttgccagca 308580
tctgctgttg gcagtgtgtt ggattttggc cattttcata ggtggtatct tgtgtttgtt 308640
ttaattcaca gttccctagt gattcataat gtggagcatc tttttatgtg cttacttgcc 308700
atctctatgt ctaatttggt aaggtgtctg gtcaggtctt ttgtccattt taaaaactgg 308760
gttgtttgtt ttctaatagt gaagttttct acagctctgt tgtgtggtta cttctttttt 308820
acatcaagat gagtcttact acctggttag attgggtgtt acttgtagag atgctctcct 308880
tccttccttc tgtctcctag agcatttgcc acacttcaga tcctcagtaa atacagtctt 308940
cccaacccaa tgcctgccac atgtttcctg acctcaagtt catatatcct ctcgcattcc 309000
ctttactcct ttccatacat aacagtggtg gtcactgctg agtccccctg aaggtgagct 309060
tatctacctc tttttatatc caagctgctt aattgctata atatccaagc tcccagatca 309120
cagcttttag ttctttttct gaatctgaac tggtgataag attaagaaat ctcttggttc 309180
ttttgcatta atttcttggt tttgctgtct actataataa tttaatagca tattttaaaa 309240
atgtttctga tggctgttta gttttgtctg ctgactacaa aggttgtttt gacctcatct 309300
tgctgacctg ccaaaagcac taagtctatg gcagtaagag agtggaaagt ctgttccagt 309360
ctctgtataa tacaattaca tgtactgtgt agcaataata attaacatgg gaggaaatca 309420
gtacaaatta gggatattcc tgaatcattg gctacactgt agataatgca gcttctcaag 309480
ccagtttgtt acaaatgggc tacaggtata tccaagtatg gattgcctca gccctcaggc 309540
agccttgacc cctgaggcta cagagcccct agcagggggg gttaaccatt tatgcaatta 309600
tgctgctgcc cagatgttat tttctataca agtagttcct ttagagagag caagtgcaag 309660
ccccaagcac tggcacaata tggagtgggg aaaacaatga ttttgaattc agaagaattc 309720
agttcctggt cagctctctg atggcaggga ttttgtctgc tcagctcact gctctatccc 309780
tgtacctaaa tcagtacttg gcacactgta agcactcagt aaatatttat cgatctaatt 309840
cttctgtttt tttttttttt tttttttttt tttttgagac agagtctcgc tcttattgcc 309900
caggctggag tccagccatc tcagctcact gcaacctcca cttcctgggt tcaagcgatt 309960
gtctgagtag ctggaattac aggcacgtgc caccatgcct ggctaacctt ttttgtagtt 310020
ttagtagaga cggggttttg ccatgttggc caggctggtc ttgaactcct gacctcaagt 310080
gatccgcctg actcagcctc ccaaagtgct gggattacaa gtgtgagcca tctcgcccag 310140
cttcgattta attattgaag catacttgaa ttcaagcatg ttacttaatc ctctctgcac 310200
ctcattttcc agaattagaa atatagttta ttcctataca gcagatataa atttatgtgt 310260
agacagttgg gctgttgttg taacctaaaa gtgacatatg cacaacctgt agcacaatgc 310320
caggtacaga gtaggggatc cagtgggttc tttcttaccc tctttcattt gaagttttta 310380
aagtatcagg tgaagatgat gatgatgatg ataatgataa tgaaagtgat attttttgca 310440
tacatttcag taaagttcat taccttacac tgatgtaatc ctcagagcaa ttcttagaca 310500
attatggttt tttaccccct ctttatttta ttttattttt gagacggagt ctcactctgt 310560
cgcccaggct ggagtgcagt ggcgcaatct tggctcactt caacctctgc ctcccgggtt 310620
caagcgattc tcctgcctca gcctcctgag tagctgggac tacaggcacc tgccactacg 310680
cccagctaat ttttttgtat ttttagtaga gacggggttt caccgtgtta gccaggatgg 310740
tctcgatctc ctgaccttgt gatccacccg cctcggcatc ccaaagtgct gagagtgtac 310800
cccctctatc aatgatgaga ctgatgctga gaaaagtaac atgattatgt aagattacac 310860
aagtgaaaca caccaaaaac agaccttgaa cccagttttt ttattttctc acgtcaactt 310920
ttcctccaca ccaaatctaa taaaatttta taaagaatta ctttaaagac taaatcactt 310980
tcgactagca tgttgtctgg atgcaaatga tggtgataaa gtaagtttaa taatgcttaa 311040
aggaggtaaa caattcctaa accttttaaa aaatctagtc agctaaagta ggtttacgct 311100
aaactttcat cagaatcctt aaattctaaa tcttgaactt ttaaatcagt aatagagttt 311160
taatgtgaat taattgtctg taacattttc aaaagataaa agtgataaat gcacaaacct 311220
acctgctatt ataaaacttg ttgtggtgga atgagacaag aatagatgta ctataagaac 311280
aagagggata tgaagaggca ggtttatgtc gatacttaaa atacatttga cgccatcctt 311340
ttgacaggaa ggaatgtctt taaaatctca caccagtgag agtgggaaaa aaatcagcca 311400
tatttctgct ttttttaccc tttcattgga atgctcagtc acttggtcta ctctggtttt 311460
gattcacaaa tgagttttca gaaatgactg tcccactggc tttttaaaag aaaaattcag 311520
tttttcctct gaagactgac acacaatcac tcagagatgg ataatcctaa atgttttcct 311580
tttccagctg aatttaatct tatgctatca acaaaatctg gaaaggttta ctttctcata 311640
tcattcatta ctagttatga attctgaacc gtatttgtaa cctgttcatc acatattcat 311700
ccctgcatgt attcattccc taaatattta ttgaatgcca gcaatacacc ctgaactcgg 311760
agaaaacata atctttaccc tcaaaaagct cacagtctgg tgctcagttg accaaacatc 311820
gtgtttcttt tctaccgagt tgcaggtctt ctctctgtgg atgtcattga atgtcgtttg 311880
cagaattcta cttgctatag taggcatctg tcttgttcat gagccacatt acaacctcgt 311940
gtgttatagg caaaaaggca atctaagaac ggcctgacat tcggacgcct aaggggactt 312000
ccctagtgag ggcacaagac agacaaatcc cagaatattt tctatatgca gaggaaactt 312060
ctctggcatc ttagaaagac aaagacagca agactgaaga tagaaacagg aggatagcaa 312120
ccttttaaac aacttgtttt tgtgaaattt gtttctgttt gctttgagaa tgggggaaaa 312180
gagaactcta attacaaact ccacgtttct ttcaactata ctattttctt tctttttttt 312240
tttttgagac ggagttttgc tcttgttgcc cacgctggag agcaatggca cgatcttggc 312300
tcactgcaac ctccgcctcc tgggttcaag tggttctcct gcctcagcct tctgagtagc 312360
tgggattaca ggcatgtgcc accacgcccg gctaatttta catttttagc agagatgagg 312420
ttcctccatg ttggtcgggc tggtctccaa ctcccgacct caggtgatct gccggccttg 312480
gcctcccaaa gtgctgggat tacaggcatg aggcactgca cctggccttt ttttttgaga 312540
cggagtctcg ctctgtcgcc caggctggag tgcagtggtg tgatcttggc tcactgcaaa 312600
ctctggccct cgggttcaag tgattcttct gcctcagcct cctgagtagc taactaattt 312660
ttgtattttc agtagagact aatttttgta tttttagtag agacagtgtt tcactgtgtt 312720
ggccaggctt gtctcgaatt cctgaccttt ggtgatccac ccacctgggc atcccaaagt 312780
tctgggatta caggcgtgag caactgtgcc caaccagtta tactattttc aatcctatat 312840
aatttgtaca gctgaagtgg caactgcttg cttttaaatg ggaagagaag atgtccccat 312900
ttaatgctta gaaaagattg acttcggttt aagccaaagg agcatcctgg agaaccgaat 312960
gattcatgat tagtaattct caaggaatgg ccatgtggct cttcatagcg ttggcccttg 313020
ggggggtcta ctttaatctt tgttctaacc cccgccgccc ctgttgtcct tttaatcctc 313080
atggatcagg tgcgttcaca gataaccact aaagtgaggc tgaaagaggt taggatgggg 313140
atggacacct gtatttctga gaggacctct ccatgatgtt taggaatggg gttgacatcc 313200
ttcacctaga aggtcctttc ccaagattgg acattgattt tggtcgctgg agcagcctca 313260
tcagcatttc tacaaggtcc ccagaaggga ggaagctatt cattgaatac ttcatatgga 313320
ggtggtttta tgttattttt atgagatatt aaggaatctt cagaaactca tagcatctcc 313380
atgttgcaga taaaagaggc tcgatggaat gggagtgagt cagttcagag ttactctgct 313440
aataataaac gtgctggctt tgaacctacg tctctctgag taataagccc ctgccctctc 313500
ttccaaagca cattccttcc cttgaatcag agagcactag atgggaaggg tgatgggagc 313560
tacattatca ctggcagatg gaactattca gctcctgtcc ttccattctc taagaaccat 313620
gcatgtgtgt aaacacatgt tgcatcagtg attgttccag gctttgccta cttgctccca 313680
aacatgtgaa aaagaagagg aagattaagt aagtcattca tatattactt atatctgagt 313740
gtttgcaatc atatagggga gcatagttcc cacaaggacc ggtttttgta aacttttgct 313800
tctctttcct gtatttaggc attatatagc tatggcagtg atcacccaca ggtacaaatt 313860
ctgtatcatt cattgccttt acttggaggt ttacaaatat ttttagtctc tacttctttt 313920
tcaaacacaa tcttgaaacc tcaacatatg aaacgaataa aggaaaattt tgttagcata 313980
atgtatgtta gatttcagcg tgtaatgctg acttataaaa tcaagaagaa agaacaatga 314040
agctttgtga tgaacacaga aatttgaaag cagtgttaga gatgacagct gcaatcttct 314100
ttaacttcag tttccaattt attgcctttt gttgttaggt atatttttta tgttgttgtg 314160
cagtattgag aaaaccctga ttccctaaaa taaggagttg caaataataa tgagttgttt 314220
tattttttta aacagttacc ttgcaagctc aggatatgtt ttcctttaaa cttatccact 314280
taaaacgtgt tcacttaaaa caaaaggaag aaaagaaatg gcttctttca aagctgatat 314340
cgctaacaat gtgaaaccat ttacattttt taattggtaa gcctgcgatt tggaggacca 314400
atgatagctt cctctagcct aaatcttcca ttagagggag aaaacacttt ttaaattata 314460
acattaatga gatgctcatt gatgtactta aaaaacaaga agaagaagaa actcataagc 314520
ctgagggagg gctcatctct ttcaatttta gaaggaagaa attgtctttg ctttgcatgg 314580
tgggtccaat cttgaacttt agatttaatc tctgacattg gctaccataa gcatggtatg 314640
tctgacagtt taatgccaat aatttaattt tattacacca ttttatacta catgtttatt 314700
tattacatac caaaattcac tgaggacaag aactcagggt gttttgtctg gtcttggccg 314760
ttaattgtcc atgatacact catgctgtac tagggtgctc acttgtgaaa tttcatgcaa 314820
gtggacgtag ggagaactta agtttatatg tttaaaaaaa gcaatggtag cgctacaacc 314880
tttctacctg agaaacagga tgtcactgag atgacgggat acctttattt tgagatctac 314940
acaagcctgg cagtatggtc tggcccatta gtagttgtgg caatgccagg atggaagtta 315000
catttgatta acggggtaac taagaatcta acttcagaag aactcttgct atccccttta 315060
accctcacaa caacagcaac aaataaatca gttggcaaat cttgaagatg tagagcctta 315120
ctaacaaaat ggagttaaga aaacccttca tgcaagcaaa aaagcttgat ctctgctagg 315180
gacatcaaag gtgcagtggt gtggacgtcc agacacagat ctgatgtagg ctttcctctt 315240
gggccttagc ctagctcagt ggttttcaaa ttccactgta tgtgagcatt gttgcacagg 315300
gtggtataaa caaaaactgt atatagtgtc cttgttgggc aatgtaagac acttttattt 315360
attgagccaa tacttacaga gtgccttctc tgtgctaaga ctcataggtg ctgcagtttg 315420
agcaaggatg aagagaagtc agttaatggg tgatacaaaa atacagttaa atagaaggag 315480
taagttttag gattcaatag tacatatcac ttgtaccccc aaaatatgta cacctgtgat 315540
atatcagtaa tgaataaata aggagcatca ttctagcgca ggaaacaaac caacaaggac 315600
tttgtggtgt aacatcagct gtgatgaatg aagagaagaa tcagaggggc gagggaagag 315660
ggggcctgct cttttagaca aggcgaccag ggagggacac atcacagcag agacctgaat 315720
gaagagaact catttgccag aggagcattc taggtaggac caggattgtg cctggatgtg 315780
gaagggagtg tggaggccac tatgctggag cagaacatag ggaggagatg ggcaggaaaa 315840
aagaggagga gggtttcaca tagttggggt cagatcatgt agggccttct aagtcttgac 315900
atggaccagg actgtggttt ttaccataaa tgtaatagga agcattgaaa ggtttgagtg 315960
gaatggtatt aggatctgat ttgcacctta caatttcaag gatacttttg aacccacaca 316020
ctctgcattg ggtgggaact ttagacccta gcccctgaat taagtgttat tctactatat 316080
ggcacatgga gagcttttct gaaactacag ttacttaata atgagaaatt caatttaaaa 316140
ataaaacgca gatgctctga agcccgttgg tagaatcttt ggggctttta aataagttta 316200
aaagctacaa gcttcaataa agattaaatt agaaatccta tataaagctt ctaagagtgt 316260
aactagcatt ttagtaatgc ttactaagtg ctggttctgt ccctttctgc tctcctattt 316320
tttttatcag cgcctttgct attaggccag gcgcagtagc tcacacctgt aatcccagca 316380
ctttgggagg ccgaggtggg aggatcactt gacgccagaa gttcaaaacc agcctgggca 316440
acatagtgcg attctgcctt gataaaaaat aaaaataggc agggtgtggt ggctaacact 316500
tctaatccta gcactttggg aggctgaggc aggtggatca cttgaggcca ggagtttgag 316560
acaaacctgg ccaacatggt gaaaccccat ccctactaaa aatacaaaaa ttagctgggt 316620
gggtggtggg cacctgtaat accagctact caggaggctg aggcaggaga atagtttgaa 316680
cccaagaggc caaggttgca gtatgctgag atcatgccac tgcactctaa cgtgggtgac 316740
agaacgagac cctgtctcaa aaaaattaat taattaaaaa tttttaaaaa atacaattaa 316800
aaaatacctt tgctattgat gtctgtttct gattgtctgt catcccggta cactatattt 316860
actttccagg gaaactgagt cattcaacaa gcctctggct tctagtgata agcactatca 316920
ttagaaagaa ttatgttctg tgtgttaagg ataagggaca cattcttttt ggaaaatagt 316980
gcttgtgagt ctaggaatag ttgtataatc tgggaatata tgctaatgct atagctgagt 317040
tcaaatcact tttttaaaaa tgcaaactta tcttctctgt caccaagcat gtcttccata 317100
caaaaggcac atttctgtag cttcatccat gttactctag gctatttcct ctagtttatt 317160
aaccacacgc tcagcaaact gtagagagta tggtctgatc cctttctccc ataataaaaa 317220
ttttaagact atgtacttgt tgatagatga caccaacagg atatatttta cagaaatgaa 317280
acaacaacat gtgaagaata ttttaggtca ctgtaaagtt cctttaatag aaaaaaaact 317340
ttagatttaa ctgttaaacc ctttgaaaaa gaaataattt atttcatgca aatgactaaa 317400
gcaaaatgga gtgtgcagaa gacctacctg catactgtat gtaaaataca gttttctggg 317460
cttcactccc aggaattctg attcacaaat ctggggttgg gcagctttca attttgagaa 317520
gtgccccgag taagctgatg tcaggaatgt gaattttaac aggcacccca aaggaaggct 317580
gtgggaaacc acatttgaga aacactgcca aattaccaaa ggaactttaa ctttgtgtta 317640
tagaaatatc aaacacattt aacagacact tctcaaaaga agacatttat gcagccaaaa 317700
gacacgtgaa aaaatgctca tcatcactgg ccatcagaga aatgcaaatc aaaaccacaa 317760
tgagatacca tctcacacca gttagaatgg caatcattaa aaagtcagga aacaacaggt 317820
gctggagagg atgtggagaa ataggaacac ttttacactg ttggtgggac tgtaaactag 317880
ttcaaccatt gtggaagtca gtgtggcgat tcctcaggga tctagaacta gaaataccat 317940
ttgacccagc catcccatta ctgggtatat acccaaagga ctataaatca tgctgcaata 318000
aagacacatg cacatgtatg tttatggcgg cactattcac aatagcaaag acttggaacc 318060
aacccaaatg tccaacaatg atagactgga ttaagaaaat gtggcacata tacaccatgg 318120
aatactatgc agccataaaa aatgatgagt tcacgtcctt tgtagggaca tggatgaaat 318180
tggaaatcat cattctcagt aaactatcac aaggacaaaa aaccaaacac cgcatgttct 318240
cactcataga tgggaattga acaatgagaa cacatggaca caggaagggg aacatcacac 318300
tctggggact gttgtggggt ggggggaggg gggagggata gcattaggag atacacctaa 318360
tgctagatga cgaggtaatg ggtgcagcac accagcatgg cacatgtata catatgtaac 318420
taacctgcac attgtgcaca tgtaccctaa aacttaaagt ataataataa tataaaaact 318480
taaaaaaaaa agaaatatca aacacatttg aaagcagaga ggtggtaaat gaacgctttt 318540
gccccaccac cccattcagc agcagagcca acatcgtttt ctctactcca cctctgcacc 318600
tggattattt tgaagcaaat tccaaataac agtattccct ggaccttgca tcttcataac 318660
agattgctgt tgactcaaaa tatctataaa atattttact atttctataa atgattagga 318720
ttcttcttct catacacaac tacaacatca tcatcacacc aaaaaatgca ttaacagtca 318780
tttctcaata tcatcaaata tcccgtcagt attcatattt tcctaattga cttattaata 318840
agttttattt tatgttgtag gattttttaa tagtttattt gaaccaagat ccaaataaag 318900
gtcatttcgg tctcctaaac ctcttttaca ctactcggta tcacctatgt ctttttttta 318960
ttttgcagtt ttttctgttg agaaaccaga ccatttgtct ggtagaattt cccacccgtc 319020
tgggtttgga tgattgcctc catgtggtgt tgctaagcat gtccctctgt ctcctgaatt 319080
tcttgggaat tgctaggaag ttctagaggc attgttttgt ttgctttgct ttgcctgact 319140
gcttcatagt tggtgttgtg ttgtgtattt ccttcaggag gtaatggttg gtggcatctc 319200
tttttgcagt gagactgtca tctgaattca taaatttatc agggattgca aatagtggta 319260
gtctaattct attattattt gttcatttgt tagcaggaat tattgttcat gaagagaaac 319320
tccttgcatc tgtaatttat ctacccggtg cttcaggttt tgtaggaaaa gcaggataat 319380
atactagatt ctgtctattt accaatttgc acgatacagc tagttcacag tgtcaaacca 319440
agtcactgtg ttttgaaagc atgactgtaa attcatagat tgcagcatat ctgttgtgtt 319500
tcagtccatg acagtgatta ccctttttca tgttcagatg gtcccctgtc tgagcattgg 319560
gatcctattc agtttggcta ctgagtcctt ttaatccaat actggctgtc tttgatagtt 319620
ttcttgcttt ctagtataac actatgttcc aggctcatct tgtacatttc ttgccttagc 319680
tctgggatca gcttttttcc aaggagacct ggtttctttc agtgagaaat gatatttgga 319740
gaccaaagac tgggccccag gggaactgtt ctcactgggt tgaatattgt ttttcctttc 319800
cagtggacac agccagtgat aggaaatctg tgtctctcta gatatagata tagatcgatt 319860
gtgtgtactt tttttttttt tttttgagac ggagcctcgc tctgtcgccc aggctggaat 319920
gcagtggcgc aatctcggct cactgcaagc tccacctccc aggttcacgc cattctcctg 319980
cctcagcctc ccgagtagct gggactacag gcgcccgcca ccacgcctgg ctaatctttt 320040
ctgtttttag tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc 320100
ttgtgatcgg ccctccttgg cctcccaaag tgctgggatt acaggcatga gccatcgtgc 320160
ctggccgtgt gtacgtattt tttaaggtaa aatacctcat gagtttatac tgatgtgcca 320220
caaggctttt acttaacttc attcatttta catcagtatt ttctttctct caaactgaaa 320280
atagcagttc tcactcacac caacacaatt tactcattta ctttctccca cactacactt 320340
gcaataattt ccgaacaaaa atgccagtga cattgcaaca atatgcttac tgaaaatgtt 320400
taaggttttt tttattttga ttgtttagtt ttgtattggt ttttagtcca ctgggctaga 320460
gatggacaat tacattacaa tatgttaggg tcatttggaa tagttacagt ctgtgtgttt 320520
atgccaataa ctggatatac atttgagttc acttacttta atttgagact tcctaagagg 320580
cttttgaaaa gtgattcttg ttcaataatt atataaaaat atttaaattt tcctgaaaca 320640
aaacccacaa aacaaggtga agtcgttgaa gtctgtcttt catgcctgtc tgctttattt 320700
tctccttttt accattttta ggcatatctt tcatttttat tataagcaat catactattt 320760
aggtaggttt tttttttttt tttttttttt ttgctccaat agatttattt atttatttag 320820
agacagggtc tcactttgtc acccaggctg gagtacagtg gtacagtctt ggctcactgc 320880
agccttgaac tcttaggctt aagcaatcct tctgcctcag ccccccaagt agctgggact 320940
acaggtgtgc cccaccatgc ccgctatttt ttttgtttgt ttgtttttcc agaccaagcc 321000
ttgctctgtc acccgggctg gagagcagtg gcaccatctt ggctcactgc agcctcaccc 321060
tcctgggttt aagcaattct cgtgcctcag cctcctgagt agatgggatt acaggtgtgc 321120
gccaccacga ccaggtaatt tttggatttt tggtagagac ggggttttgc catgttggcc 321180
aggctagtct caagttcctg gcctcaagtg atccacccgc cttggcctcc caaagtgttg 321240
ggattacagg tgtgagccac catgcccagc cttccagtaa aaatgtttag aataattcct 321300
taatatggta cccttcttat cccccaaact tttcttagct gttgtttatt ggtttccaac 321360
tctgagtgat tttgaaattc ttagtaccct ttctttctta ttttcttctc tggctataat 321420
ttgatttaag gtaatatcct tttactccca cttaacatct atgttagtga gattattttc 321480
gttcctttca tattcttccc gcgtgttttt ttttaatcat tatactatct atattgtcag 321540
ggcacatagt cattatatcg ttctggctat atgtaatatt gtttccttgt aatcatcttt 321600
cagtaacaga cctacagctg attatgtgtt aaatgctcac ccagtctttg tatcagtgcc 321660
tttccagcca gactggttgc ctgactcttc tcccttgcag attactaagg gtttctgcga 321720
acaatattcc ttgggtcctt gcatattcat aacagattgt tgttggctgg aagatcattt 321780
tggctgggta taagatcctt ggcttagttg tctttcctga gtgtcacgct actgactttt 321840
agcatgaagc ctggctcttg aaaaatcggg tgacactcta attttctgtc ccttataggt 321900
aactcagtca ttttacctga gtgtccaaag aatttttttt tgttttcttt cctaggtcag 321960
tttttccagg tgcatggagt attctgtcaa tatatagttt caaatctttt tctacttcta 322020
gaatttgtgc ttcagtcacg attttaagca tttgctgttt ttattgcttt tcttcttcaa 322080
aggctcttat tacagtgtta tgttgggttt tctttgctca tgttcctttt ctgagtcttt 322140
ctcttgaatt ctatttcttt cctcatttct ttttgatgtt taacactttc tcctttctat 322200
tttttagcac tcctcaaaga ttatctgttg tatgtattcc ctcttgtgtt ccttcttatt 322260
tggtcttcat ctagaaaatg gattttcttt tttcgttttc ttcaaattct ttcccacgtt 322320
cttttgcctc tctctatcca actatttctt ttctccaatc acttcatttc tgaatgtttt 322380
tattgggatt agtgttcctt tatctcttct tactgcctca ttttctttta gctcttttga 322440
aatattaaag ttttcatctg ttttgggggc atgtctctgt ggtaagaatg ctactctgat 322500
ttttcttctt ataataactg tgcactgtat ttgaccacaa tcctattttg ttactcattt 322560
ttaagtggaa tgagttttct tgtattttta gggataaggg atgggccaga aaatattttc 322620
tagtgtctag gccatagaac tccgtcttct gttgtttcca tggaataaaa taaggcctat 322680
attttcttag cttcgtcttc tctgcctccc ttcacttgga tctgccccct cccttcactt 322740
tggctaaatt attactgcca tgttcgattt agattctgct ctcaaaagtt tcttctcaag 322800
gtgatttggt cgtggaagga agcttagatt tgttggtctc aagagtgccc tggctccgta 322860
acacctaagc acctcagacc ttcccagggt tccttgccct caccccatga attggattct 322920
gcaggacccc ttgccaatga tgctgctgtg ctcaaaatag ctcaccaccc tgctgaccgt 322980
gccgtaagga cctttggaag cttgggagcc cgttgtgcca aaaccttcag atgcccactg 323040
cctctcctcc aactttctct tgcacagata ttgcttctgc ctggctctgt cactataaat 323100
ggttcggcca cacccattcc tgtcttcagg tttatggact acacagtaac ctcattttgt 323160
cttgatgtgg tccatgggtt tttggctgtg taattccaat ttctctgttt ttgttgttat 323220
cattgctatt gttactggca gggaggagga gggcagggat tctgaaaaat ttttttaaac 323280
tgtgctacct ttgacactgg tgccatcatc ttccctgaat tcccgcttta attttttctt 323340
ttcttttctt tttttttttt aagacagggt ctcactctgt ttcccaggtt ggagtgcagt 323400
ggtgctattt tggctcactg caacctctgg ctcctgggtt caagcaatca tcccacctta 323460
gcctcccaag tagctgggac taaaggtgta tgtatgtatt ccctcttgtg ttccttctta 323520
tttggtcttc atctagaaaa tggttttttt tttttctttt acttcaaatt ctttcccacg 323580
ttcttttgcc tctctctatc caactatttg ttttctccaa tcacttcatt tctgaatgtt 323640
tttattggga ttagtgttcc tttatctctt cttacttcct cattttcttt tagctctttt 323700
gaaatatcaa agttttcatc tgttttgggg gcatgtctct gtggtaagaa tgtgccacca 323760
cgcctggcta attttttgta tttttggtag agatggggtt ttgccatgtt gcccaggctg 323820
gagactcctg ggttcaagcg atccacccat ttagacctcc caaagtgctg ggattacagg 323880
catgagccac cgcacctggc cccacttcaa tttttttttt tttttgagac gaagtcttgc 323940
tcttgtcccc caggctggag tgcaatggca ccgtctcagc tcactgcaac ctccgcctcc 324000
cgggttcaag tgattctcct gcctcagcct cccgagtagc tgggattaca ggtgcctacc 324060
atcacaccca cctaattttt gtatttttgg taaagatggg gtttcaccat gttgcccagg 324120
ctggtctcga acttccgacc tcagatgatc tgcccacttc agcctcccaa aagtgctggg 324180
attacaggcg tgagccactg tgcctggccc cactttaatt ttttaatagt gcttgagaag 324240
atgtttctgc taaatactat gcctctggat taaacctcaa atacttcaaa atgaaaagtt 324300
tgatttcggt cacagatttt tagtaaatac tttttaggga caagaaaact acaaagtgct 324360
ttgaaaaaca aaacaagctc aattttttat ttgtttaaca tatgtagaaa ataaaattaa 324420
tacacgtatc ttttccaaat taacacagta tgaaaccaac cactactaat tcatcaaaag 324480
acacaattta gatcaagttt aggcttggtt aggacgctgg acgctgagta aatggtagct 324540
ctgaggctga aaaaaaaccc ctgagtcact ctggtacaca ttctgatgtc agcatcccca 324600
ccccacccca acccttattc ccgccccgcc cccggccccg cccccccccc cccccccccc 324660
ccgcgaaaag aagtctctag ctctgaaaat tggcttgtta taactttaca aatgtagttg 324720
ccaaattgcc attgacatca catttttctt tttggctttt agtagctaga tagtaatact 324780
ataaaggaac tctctgcttt ttctattttg tcctttttaa attcttggag gcccttcata 324840
acatggaaca caggatgggc aaacgtgctt cttatagtgt aggttagatt tagcaccttt 324900
tgacaaaggg ccttgtttcc tgtgcagttt aaatttagat ccactgagaa tctgagaaat 324960
tcagtaatga aagggtaact ttggagtttc ctcttttgga agctttcctt attaaattct 325020
attaatgact ctgttagact tgattcccat cttacacaag agattccaga atagcaactt 325080
gaattgcttc ttagtccctc ttacgaagtc actccttcat ttggcattga tcgagtacct 325140
cccgtgtact ggctgacggg gcttatatac agagccacta ccttattttt cattctgtta 325200
ttttaagagt ttcttgatag tccatctact taagaagtgt tgctattaaa tttcagtcta 325260
tctcataaat attattctga gatcctcctg gctggattta taggtataaa tcattcttgg 325320
ataaaatata caatataaac agtaagtgga ccagttatct gattatacgt gctctgagtc 325380
tacagaaaga caatatcttg gtatgtttca ggagacttgt agagatgagg tgtaggactt 325440
ctcatttcta attaaaacta attaaaattt actgtctaca agggagatgg attgaacatc 325500
acctttacct ttctcttgac agcaatgaaa cctgactcaa agctggcact aaatgtatta 325560
tttcagtatc tgtgtcctat tatgtgttgt aatattttgg attaaaaaat ggagaaaaaa 325620
taaacaagaa atttttattt ctgctaaaaa gtcaacagag tccattgtta tctttctttg 325680
cttttcagat ggcagaaatt gggtgtcagg tcctataaca caggggttcc caacccctgg 325740
gccatggacc attatgggtc tgtggcctgt taggaactgg gtggcacacc agtaggtgag 325800
aggcaggcga gccggcatta gccagctcag ccagcctaag ctccacctcc tgtcagatca 325860
gtggcagcat tagattcttt ctcataggaa agtgaaccgt actgtgaact gcacatgtga 325920
gggatctagg ttgtaccttc cttatgagaa tctaatgcct gatcccccta cccctagcct 325980
catggaccag tgccaaaaag tttggggacc actgccataa gaagtcccga ccagaagtgt 326040
cacatctttc tattgcatga tgctgcttct tgaacaccca tagtagccaa ggccagaatt 326100
agtgtggcac cctcttcccc agacaaggtc catggacagt gcatttcaaa atacaggaag 326160
ctctccttac actctctgct acctagcttc catggttatc aagtaattat actttatgct 326220
gagccaactt atgcatttag gaagagatga agagaaatta tatcctcaaa tgggctggaa 326280
caaaagggaa taccaataat ttgtaagtta atcaaattat aattaaagca ggaagagaca 326340
caaggagctt ggattatcta tgttttctgt tagaaaataa tacaacaaaa gtatccaggg 326400
agtcttatca gttctgtagg aatttggcag aacagtaagg ttataagttg tccttttaat 326460
tcccagccac ctctggcctc tgcttaccat ggccctgcct tctgacttgc tgtttgctca 326520
gctccttagt gcatgggaag agcagaaaca tcaggggaag agcgctgaga tctgctgtgc 326580
acctgtgccg cacagccctt cccatgtaga catgtgtagc ttttgggttt gccagtggat 326640
ggaacttatc cgcatcaagt agccttccac gggggtggtg ctgatacgca ctcccaccca 326700
cagccgatac agcctaatca caagtggaac aatcagagtg gaaagtagcg gaaagtagca 326760
gcctctggtt tccaaatgtg agagagcctc agggctcagt cctcaaacct ggtctgtttt 326820
ttgttgatgc cttcaaacca tctcaaaact gacaccttct ccagcctggg ccttttcttt 326880
gaacctcagg cttgcatatc ccactgtctc ttaactgcct tcagtgggat gaactcttga 326940
tattctaccc caacctgctt ctcccactgc cttcccatct ccttccagtt actcaggcca 327000
cagttgttga cgttgtcctt gatgcctctt tttctcctac acaattctgc tggtccacgg 327060
tgccaccatc tcttggctgg agttcatcag taacctcctg agtagtctct ctgcttcttc 327120
tcagaatatc tcctccatgc aacagccagc atgaactggt gaaaatgtag tccagaccct 327180
gtacctcctc tgatcaaaac cctccagtgc ctctcagctc actcagagta aggacctcag 327240
actttattgt ggctcaaaga acttgtcacc cccaccctct gacttcattt cctgctcccc 327300
acccccttta ctcagtgcca ggaacaccac ctcgatggtg ttcctccaac acaccacaca 327360
ggagcccacc ccaggacctt ggtaccttct gttctttctg tcaggaaggc tcttccccca 327420
gtcaccacat tgctttctat ttccctttct tcaggctttt ccccaaaagt tactgtctct 327480
gtgaggtctt ttttgactga caagcttgaa aaaatggtca ccagaccacc accctagccc 327540
ccttttctgc ttaacttttt agcatctatc accatttaat ggaaaatact tcattataaa 327600
tcttttattt ccatgaggat aggtaattat ttgttgttgg gggtgtcttt gtcagcatct 327660
agtacagtgc ctggcagatg gatgctcaat aaatattgat ttaatgggtt atgagggtgt 327720
taatataaaa ttagcattta ttcagcaact actatgagtc agccactggg ctaagtggct 327780
tacatgttaa gaacctcaca gaaggccagg tgtggtggct cacgcctgta atcccagcac 327840
tttgggaggc tgaagcaggc agatcacctg aggtcaggag tttgagtcca ggctggccaa 327900
cgtggtgaaa ccccatctct actaaaaata caaaaattag ccagttgtgg tggcaggcgc 327960
ctgtagtccc agccactcag gaggctaagg caggagaata gctggaaccc gggaggtgga 328020
gattgcagtg agccaagatt gcaccactgc actccagcct gggtgacaga gtgagactct 328080
gtctccaaaa aaaaaagaaa aagaaaaaga acctcacagc aacctagtag gtgagcactg 328140
ttactcttgt tttacaggtg agaaaattga gccctagaga aataaagtaa cttgcttcag 328200
gtctcatggt taaggggaac ctgggcccta acagtccact tcctgtacct tcaaccacgg 328260
ctctaccgcc tccgctagga gatggcccga ggacattcct tagctggctt cagcttgctc 328320
tttttcccct gcggtccacc cctgtctcct gcttggtcat cagtgatttc catgccatcc 328380
catgtcattg gaccagttgt gtgtttttaa taggagttct catctcactt tctccacagc 328440
tttgccaatt ctgctctccc cctcctgtct aaataccttc ctcccttggc ttcctgaaca 328500
ccactgtctt cgggtgccat catccctttc tggcccctcc ttcctaagtc ttcaggtgtt 328560
ccctttctac ctgctttcta cgcctctaag tgttggagtt cctcatggct tagtctctag 328620
accactttgc ttctccactt aagtgttctg ctagatgatc tcatccaaac tcacagtgcc 328680
ttgatggatc catgactcct gcatccatgt ttctaggcca gacctctcat catcttcggg 328740
cctgtgtctc cagctaccta ctctgcacct cctttggggt atcacaatgt cacctgaact 328800
cagcacgttc aaagtcaaag ttataacaat caccatccca ccaaacctca tctacccaag 328860
aattccccat ctcagccatt ggcatcatct agttacccaa gacagatgcc taaaagtcct 328920
ccttgaagca tttctgtccc tcttcctctg catctaatgt gtcaccaagt cctactgatg 328980
caatctcctc agtgtctttc gaatgcactc tctctcttcc ggcccactat caccattcta 329040
gtcctaaaac ctaccttctt tctaggagcc acagcttctc tggagttttt acacctcttc 329100
caactgttcc catcaccccg ttcttttctt tgacaacatt ttttacatat aaaaataggt 329160
atttatgtga ttatatcatg aatgtctttt ctccccaact aagaagcact atgagagcag 329220
ggagcttcct gtttctcccc gttcaatcct cagctcctag cagcacagtg cctggtgtat 329280
agcagattct ccatcagtat ttgatttgtt gagtgaaaaa cttagatgta ttaaatgaca 329340
aactgagatc aagggagaat gaagaatcaa tcagaagcag atagaaaatt atgctgtgtg 329400
gtatggcaac atcatgaatg gactgttacc gataatacac actgagtcat caaagaaaca 329460
ttaacatgta ttctctattt taaaagggag gtacataaat atagaaccaa ataaacagat 329520
ctcaggaaca tttccattca gtaagcaaag ttttagaagg gaaagagaaa ttaagttcac 329580
atcatttccc aataacacag atgaatgttt tccatccaat tctgaggaca aagatagcac 329640
ctcctcgccc atccatgcca acggaggctg aggtagcaca gataattgaa attacagtga 329700
agaaggaaag gggttgattg atttgcatgc catctctttt ctttaatagt ggaggaattg 329760
ccaaaaaagg ctaaaaatgg gcaacaggaa aagggagaaa cagtaagaat cttggataat 329820
cttccactag ataattaaga cttaactggg tctgttttga tgtgtgcaca tgtttctgta 329880
catggagaag gatgaaccca caaatattat aaatgccaat ttccgaaggc ttttggaaaa 329940
tgtaacccat agcatatggt gtcaaattaa tttggggttt tacttgtttc agtctgattt 330000
gggcacattg aattatgaga taatagtttg gcatccatgt ttgctgagtg cttgttgtaa 330060
gtttctcaat ttcacaaaaa ttctctgagg ttagaggacg cgtcgtgacc ctcgtttggc 330120
aggtgaggag gtagcggcac agagccgatc cgtggctcgc ctgagctccg gcaggaactc 330180
ctgggcggag ctgctgagac ccaggtctgc agactgtcac tctggcttca ctatttctgg 330240
ccttcctttg agcacttttc ttacttttgt tctgtttcat gcacttaatg cacctgtttc 330300
atcatgctgc ctgtcacagt taaaggaatt taaaacagaa tggatcgtat ttgacagtaa 330360
ggagctgtac agctgaattc catcaagaca atgtgcttgt agccccaacg gcattaaaac 330420
tttcaaatga tgctttatca caacttcctc tgggctgcac gtgacaaagg ggtgcttaac 330480
caggagggac atctctcttt gcttgtaggg gcaggttgct gttttttgcc cacctctaaa 330540
atctccttgg agcactcagt tcttcttatc ctccttaaag ccaacaacta taaaatttaa 330600
tttaatgttg aacagctgtt tctgttgcgg tccaggtgaa atttgaggta tcagctaatt 330660
gtgctaaagt tcccaaaaag aagtattcag aaggtgtgga tcaccaatta cctcttggca 330720
gagctgtgaa ctaataacta gtagcagtag ataatgtact cagatgccac atgaaatgca 330780
aaagattcta tgctttattc cataaagcat ggctatagga cattgtctac tatgtaacta 330840
atatttaaat atttatagat ttttaaaaga tttcttcaac cttcttttct caccctgttt 330900
ctagatctga tgcacaaagg aaaataataa tacaaaaccc ataacctatt cattgtattg 330960
ttgcggtaga tcgagctaca tgctgcacag caaaagacct tctttgcact tctttcaagc 331020
agaattattg ctgtatattc actctgaact gagaggtgag gattgaactg tgtagtgcct 331080
cagaaaatat caagagtttt aaaacattag ttttgagaga ttgaaataca tagaaacttg 331140
gaatgtttga atgtcagccc agacattggc aggcttccat gcagatttca ttgtgagtaa 331200
aatgtgtact cagtggctgg gttcaagccc ttcatagttt ataagcaaat gtctctgctt 331260
cttctagatc attgcaaaaa aaaaaaagaa gaagaagaag agaagaaaag aaaaaagaaa 331320
taggttaagc aaattttgtg gtggtgctta tgtgtgcaca gacatgcatg aggcctccgc 331380
atcttccaaa cttggaaagc atattttaac agcacaaata tatctacatg tttgatctac 331440
atcagagcct ctttttttcc ctcttccttg catgctttta aattatatag tttaaatgtt 331500
ttaactatta aatctgtttg gtcttcaagc tgtaaacatc acacacagct aataagcttt 331560
aggaaagaaa aggaaattga catttagtat agaggttcta caaaaccaat gaaaaccatg 331620
caaatgagct atggaacaga gagatttgca tatcctcgtt gatttcatga tgatattctc 331680
agcatgagcc tggcagcctt gcctttttac ctcttgggat gatgcatgta ctggtggtag 331740
agccctgcag ggtcaattta acgagtgtaa cattgtgatt ttccatgcgg tttctcagaa 331800
ccactgagca aaatgcagca ataaccagtg acagaggaaa tcgatttttg aagtaaatac 331860
ttttggagga ggggaagaag gtacattccc ttcatattta atgttgccaa agtaggttga 331920
acaagttttt atattagtac catttggtat ttcaaaataa atagattatc caccatttcc 331980
atcactctct ggataccctc acatgtttac caccaaaact cctgcgcaga gactggtcct 332040
cttttgcaaa ctgcctttgg ctcccccgcg atctctcatc agaaaagcag gctaaggaat 332100
ctgcttttgc ccccatcctg ttagaatgat aaatagtagc ctgatggcca agttgtatat 332160
ttatttaata catcgtctgt attgatagtt tatgatgtcc tggatatgaa tacacgaaag 332220
cacagttgca tagtggcgaa gaaggatttt gatatcgtgg agatctggat ttgaactcaa 332280
ctctggcagt tctccctgcc ttagtttctt gcccgtaaat gggggtgatg aggtagttgt 332340
gagaattaaa tgagagacta tgcaaattgt tataatactc cctggaaaat agttaaatac 332400
ccaatagata gcatcactat tttgaaatgc tttcaaaatt atactcgagt tttacttctg 332460
caaaatcaag gcagctttct tcagaaaaga gagaaatgaa cttcacccct aaaatgtact 332520
tggagaattt tagagggtct tttccaagtt gttataaagc acttctgaag tgaatttgcc 332580
catttctgcc cacaccaatc ttataacatt ccaggaataa aatctgcact cgagtttaaa 332640
aataaaacgg gtggaacaaa ctgaattaga agtccttggc agacatcccc cccagcagaa 332700
tgttctctca attggtggta ttgcaataaa agagatgtat attttttagt ctgctcttcc 332760
tccctgataa tttcagccag ttgtatttct ctattctaaa aacctggtat gcttggattt 332820
aatctcacca ctcctatcta cgctcctgct cctaccccca cacccatttc ccccaaaaaa 332880
accccacatc tgcacagacc ctccttccca agaaaacatg gaggcgggct gctctctgat 332940
accgtacatg tgcattccgg actgtgctga ggaaggtcat agaaacatga gagggctctg 333000
ctgttgtcag ttgtaaagac tgccaagaaa gaacaacaaa aaaatctcaa atgcattcac 333060
atttctcccg cctctttttt cttctgtaaa tattcaaccc tttttagaga ggcttttgat 333120
aatgtgttat ctcagcaaac accacgaacc ttggatgtac gcagtactcc ctaatcccat 333180
aggaatgact cagtcaagag agttagatga aatatggttg gcaagattgg gtggggaatc 333240
ttgttactac acacacatac acacacacac acacgcgcac acacacacac acaccagcag 333300
caccagccac tgcaccccta tcatcgccat agacattatg taaaaactag acattctcct 333360
ctcccttaca cagtcagttg catctttccc aaaaatggaa ggggaaaaag ctttctttgg 333420
ctgagccata tgcaaaaaat catggaacat ctgtgtaagt aacaacatac aacaagacaa 333480
attattggtg gtaaaaggca aagcccttgt ttcaaaaaca tgtctggaaa tagtgtgtat 333540
acagaacctt cctttgtgct aattactcat aataactgtc agctttgtgt accacaggct 333600
gggctgttaa taactagtgg tcgcagtacg gtgttctttt tctttccctt tctttttttt 333660
tttttcctat ccttccttcc ctctttcctg ccttcttttc attgttgttg cacaaatcat 333720
atagccttat tccaatagtt gctggaagac caaatcagag atgtggggga ttcagggact 333780
cgcgacatct tggagtatac tagtggataa atgccacttc acccctgatg tggccgtttc 333840
cctccaacac ttgtctaagg agtgcaggga ctttggggtc caagcaatgt atcagtaaac 333900
ttcagaattt ttttcctaac atttaactct attctcagtc tcaacacccg ccacaaaaat 333960
aatgtcactc caggcaaatt tagtcgctta cggattctga gtcttattgt gattttgcct 334020
gagtggcaag cttttcaggc acgtgtactt aaaaatgtga tgtggtagaa tttgcctcca 334080
gctaggaatc cacagacttg ggtttgagct ccacgtccca cagtcaccac gtgatcttca 334140
gaaaagaatc actgaactgc ctgtgcctcc atgcccccgt ttgtcaagag ggaggtggta 334200
atacctgctg cggtttttat gtggatcgaa tgggcctaaa actcatagaa acacagaatg 334260
cttctatgat aagagaaaac tccagccagg ctcagtggct cacacctgta atctcagcat 334320
tttgggaggc cgagatgggt ggatcacctg aggccaggag tttgagacca gcctggccaa 334380
catggcaaaa ccctatctct actaaaaata caaaaattag ccaggcgtgg tggtgggcac 334440
ctgtaatccc agctacttgg gaggctaagg catgagaatc acttgaacct gggaggcgga 334500
ggttgcagtc agctgagatc gtaccactgc actccagcct ggaggagact ctttctcaaa 334560
aaaaaaaaaa aaaaacgaac aaaaaatact ctgatgctat tgctactggt tgtttttttt 334620
tttaatgcta aaaggactcc aaacatcctg ttatcaccca ctgtcaaatt tctgcatata 334680
ttttgcagtg ccagtgagaa acttggggtc tctacagtca gtaaggaaaa aggagtttga 334740
aagaactaag ggatctctgt ctatggggaa gaaatagtag ggcagagaat ttaaatttag 334800
ggttcttagg aaatgatgca ccagggccac cgcacagccc tcatgtctcc tctcttcagt 334860
gtcctctctg cctccatcac ctagtgagga gggaacaggt gcaggaacag gtcgccaggg 334920
tgtccagcag gtgacctccc acccccctac cctcgccgcc cccactgctc cactggcagc 334980
ctatgtccca accaaacctt acttcacatt gtaattctaa tgttctgtgc gtgttcatcg 335040
ccatatttcc ctccatctga cccagcccgt caaaatcctt cctctacttc agggcccagc 335100
tcccatcccc tcttccgcaa agccttctaa ccgcaaaccc attaacctct ccccacttgg 335160
ggcttctgag tccctttatt atttatggtt aggagaaagc atcacgtcgg tctggtgatg 335220
tgtagtgagt tgtgtgaatg tgttagcaga gcagggtggc cctgcatgtg atggttgggt 335280
gttagctgga gtgagccagc ctgggttcaa atctccctct ggcatcagct tgtgctgtaa 335340
ttggggtaag tgctgaaact ctccctgtct cctttcctca tttgcaaact tggcttaata 335400
atgatagcta cctcaaaaag ttgttgtgat aattaaatga atgtcaagct cttggaacag 335460
tgcaagcgct taagaaatat tatgttggtg caaaagtaat tgtgattttg ccattacttt 335520
caatggcaaa aaccacaatt acttttgcac caacccagta tttgctatta ctagtcctgg 335580
tcagctgagc atggtggctc atgtctataa tctcaacact ttgggaggcc gaggcaggtg 335640
gatcgcctga ggtcaggagt ttgagaccag cctggccaac atggtgaaac cccgtcgcaa 335700
ctaaaaacac aaaaatgtgc tgggcatggt ggtgagcgcc tgtaatccct actactccag 335760
aggctgaggc aggagaatca cttgaacctg ggagccagag gttgcagtga gccgagattg 335820
ccccattgca ctccagcctg ggtgacaaga gcaaaactac atctcagaaa aaaaaaaaaa 335880
aaggcctggt ctaccagaga caagaggcca tgtcttgtcc atgaaagcct tgcaaccata 335940
ttttacagat agaaaagacc cagtccatga acattaaagt cagtatcagg tacatttatc 336000
aacataaaat ctgttccttt gaatcagctc aataataaaa gagtgcagct gagcaccccc 336060
tcccacagcc ccatgcctct agtcactgaa aatctgtgag gaatttttat agagtgtttc 336120
agaacagagc atttcaagac aaccctagag ccctatggaa tacattttca atcatctttc 336180
tgcgtctgct ttcttttttg ggtgcacaca gcagacactg gtgatgaggc atgtgcctgt 336240
gtgcactgtt gttttataga agctgaatga aagcctggga gttgtatctg cctgaaaact 336300
tccatcctgg cttctagagc tcaacacctg aaacgctgga ggcagttgag gtcactttga 336360
aaacggaacc cttgatgttc tgctcaaact ttagaggcat ttacaacaaa tcaggcaaat 336420
gaaagtgtgg aaaaatcaga aacgaggacc actctgtctt agggattttg tcattgtatc 336480
gtgtgtgtgt ttatgaatgt gagtgtgtgt cacatgtgag tgcatttaac cttcatgcaa 336540
taagagagta gttttccact tagaaccagc caactctcta taaaatttac ctccgtgatt 336600
ctaattttgc tccctccgcc gtgggcaagt tggcaatgtc tgaatgtctg aagtcatttt 336660
tgcttgtcac gactggggag gagctaccag catctagtga gtagaagtga ggaatgctgc 336720
taaacatcct gcaacacaca ggacagcccc caccacaaag aatcatccag cacaagatgt 336780
caacagtgcc aaggctgaga aaccctggtt taccttaacc ttaaaagaac aattcgaatg 336840
cttgggaagg gatgtctgcc acatctgtac tggagagaag catggccccc agtcaaggac 336900
atggagagtt ccatgtctgg atctagaccg tgtccatcca caaagatgcc tcctgctctt 336960
ctccgacata caatctggtc catgagaata gactttattg gtgagggggc ggggctttag 337020
gtgagcggca ttgaagggct tgttctgagc ttggcctctg ctggcagatt attttctggc 337080
cactttaatc tcgatcctgc ctctacttgg tctttttttt tttttctttc ccccagtttt 337140
tggatcttat agttccacag gacaagatac atctaagaga tgggggaaaa ggttaaagca 337200
gcaaggggat gctggataga gggggaggga aacaagaaag gaaaaaacaa gacagagaga 337260
cagagataga cagagatgta caaatggggg ctgcttggtt aaagtgtcct ggagttttca 337320
gcaagagatt ttgctgccag tgtctctcca tccttctctc tgcctctctc tctctctctc 337380
acacacacac acatacagac acacacacac acacactcgg ccccaccacc acacacaggc 337440
caggtggctc tgcttacata catggcttgg cgcttttact ccttggctaa gaccatttca 337500
cacatgaaca acacagcctc ctcctagaga tttgtcatcc atctgcttgc agaagagctg 337560
tctgtttccc tctgaaaatt ggtccaatca acattttcct ttggccaggg tagcttacca 337620
gcagctcctc cataaggtcc ataattgcaa tttctcattc tcatttgcct ggctggcttc 337680
acccttctgt cctctctgca ccttcccaca agtgccccac cctccccacc agccctctcc 337740
tccttttgtg ttaataagcc ctgtcaaaat gaatgacaga atcaacttcc ttctcccaaa 337800
atggctcatt actcataaat ttcaagcaat attgccttct gtcctcaaaa ggtttgcaga 337860
tttttttccc ccaactgatc ccctttccag agtgaaatag cggatgaatg ccttgcctag 337920
caccctctct aagctctgcc tctgtggcag tattgtgggc caatatgcca acgagtcttt 337980
ccttgtgatc tgctccagcc tgtcttgtgc catatgcttg tggcagacag tggttaatat 338040
cagtctgtga gcatcttgag gctagctttg aagtctaatt ctaatgtcat catgcttata 338100
gggtgcacac tttgtttgtt ctggaacaga gggtcatctg ctacgggatg tggaacactg 338160
accctgatat tgcagccgtg tttgtggttg agtgagggag caggtgatgg gcataggagg 338220
gaaccaagcc ctgagccgtg tttcagggat gctcggtccc atcccctttc tcccagatga 338280
cttcttattc ttaaattttg aatagtgagt aacacaagca ggaggtggga tagcatgaga 338340
acttaggaaa tcttcccatc tctttgttac ttacaagata aatgtctata ctgaagcttt 338400
agggacccag attacaactg aattgtttta taaatgcgtc tgaaatctgc tgttttgaag 338460
gacaaagtaa tacctgaaga atgattaaga aggcttagag aatccgcagg ctccaaggtg 338520
tgtgaataat acctttccat ggttcactac caggtgatct ggacctacag ccagtcttct 338580
gtgtttcagt atattatgtt gggagcattc ccagacagtt aatgcgtaaa atgctattca 338640
aattctcctt taccgaaagg cattttaaag taatacacgt gggtgaggaa tacaagtgcc 338700
tggtgggata cttttggtaa acaacgtggc acagtgggat ggagtagggt ctactttttc 338760
ccaaatgtga agttagtagc tacagagggg tcctgagaca gaaagcattt gtaaatatta 338820
atttgtgctc tgtttcacag aatctgaaat caggcatctg tgcactttaa aatatgaaag 338880
aactaagaga tctagtgttt ggtagcattt tagagggaaa aaaggccata gctcaaatat 338940
tgctctgatt tcagttggct gaatttatgt gtaaagggca tgttagggaa tagtctgcaa 339000
aggtaccaga aactgccatt catggaaggc cctgagtgca aaatgcagca gtcagtagtt 339060
ctgacccatg ccattagatg gttctggaag gtcctcagag gagacgcaac accaacagtg 339120
acactgcttc cagctcaggc aggctggagc tgttctgagt cttcctgaag gttctgaatg 339180
gtccagccct tggactccct tcagagagtc atggagcacc cacatttcct ttgcacctga 339240
aacacttctt tgtttctgtc ttcaccctga ctcctcatct attcagagat cccagctgat 339300
cctctctttc aaagccaggc cagtgagctc ttacagaagc ttacttcagc attccttcca 339360
ccgtcttctg agtagcaggg cagacagaga cagcaatgga gaattccagt tgattcccca 339420
taaaatggcc actttgttgt ggggcatgag ctggtctgta cttgtttgtg cctggcagtg 339480
cacacactag aaccctgggc aaccctggat gtaaatcaac tagatactat tattaaatag 339540
ccgaaggttt gccagtgcag cctggagcaa agagagaggg gtaaaatcag gctcccaaca 339600
gacttcccca taggaaacct ctcctctgct gtgattttcc agatgagctg cgtaaatggc 339660
tccaaatcac cgaatgtttg tgcacgcagg ctccattcat gcgcatgcac acacccggct 339720
tgtgtccttc ttccctctcg tcccttgaac ccgtagctct tgattctgcc tgtaggagca 339780
atgatgttgt agcaaccatg acaaaagaaa caaaatcaga aggcagatcc aggccgctcc 339840
ctgccacctg ccctctgtct accttagaca gatcacttag gcccactggg tcttgataag 339900
acatggtctt ttcacacctg ttcttccagt cttataggat tacctggagg atcatgtgat 339960
gcgaaggatg taaaagtgct ccaaggggtt aaaaggactt tatataataa attcctacaa 340020
actgctatag gcacagccat agctctgaaa ctagcattct cgtaaggcta gtccaatcca 340080
taagtttcgt ttgcttcaag cagctcagat agacactctc tgaagataaa tgatgcataa 340140
aaacaccatt gtttgtgatc agaataatca ggtaccacta aatagtcctg catgtgtatg 340200
catgatacca gcagcctcca acttgcttct ccaggagcac tgtacttaac ttggaaaccc 340260
ctttatttaa tttctgtcca ctcacaaagc ttcaccttgt cttctctcct ctctgtcctc 340320
ccgaggttaa tccttgagag cctgtaatca aggctaggcc ctgcccacct taagtcaccc 340380
tcccctctct ctaggcctcc acctcactgg ggagcgtcat tgcagccagt ggcaagaagc 340440
tgcaaaattc tctcatctgt gaagagagcc cctaaaaccc caaatcccgg accagtagag 340500
gaaaccattg ctgccctaat atcacatgtt acaagtcttc gagcccatgg tatctgagat 340560
gttaggagct agcattcctt gtaattaaac ccctggaaca tcacaaggac ccagttcagg 340620
gggcttggtt ggttgactga ttgatgacag catctcaatt atgtaggaga tttctgtaaa 340680
gaggagtgac tggaaggaaa agaagataac cttcatttat atcatgagac cttgcgtagt 340740
agaaggccgt gaggatggga acaaagtgaa atcatgaaaa acagcctgat gcaaaatgac 340800
aaagaagaat ttcagggtcg ttgagatcac acttgaacaa taactgaaca gagccagcac 340860
tacagttttc agacctgatg gctaacaagt gaaatgtatt cagagagagg tgtgtgatta 340920
taaagactcc ccctacccct ggtgctctat tccactgact gtccctttat gaaaaatgaa 340980
ttctagagtt ccctttctga aatttcttac ctgaatcaga tcagatatga caattctatt 341040
ttttaaagca ccttactgaa aataaagtgc ttttcagtag taaaccttta agattcctgg 341100
tttccctctg acttgtgaaa atatgaaaga actgaaatta gaccacattg gcccaggttg 341160
ggaaaacaga tggcagagat aaggcagatc aaagaaacat ctctctgtgg gtgaaggagt 341220
tcctggttgt catgtatcca ttttttgtag cgttttccct acttgaggag gctgttgtga 341280
agggcaggat tcttcactga atctttattg taaaaggcat aggtgtgtct tgggtggatt 341340
ccagttctca ggttgatttg cttgacaact cttaggaagg aacaattaat actgctgccc 341400
ctcaactagc tagggagatt tcactgtgga ggtagaagtc ggattcactg aggcagaatt 341460
gccagggctt gagacccttc atgcctctct tttccaagtc tctctctcca agaaagggtg 341520
aacttttcaa gtcaaagagc agggacgtaa ataaatgcag ttatggctgt cttaggagga 341580
tccattcact taaggcaaag gtcttagaag ttacagaaga ggagagagaa tgggaactac 341640
tgtggcacca ggatgtctgg agaagagaaa gtgcgcttac tgtgcacagc ttcctctccc 341700
tcacctgcgc cacggtgaac ccacctatat ctttctgctg gcaaaaacat ttgctcagtg 341760
tgtcgccgga gtacttgagt gtctgatatt tctcaaggca gaatctacct cactgtctct 341820
gaaacctcaa aatatgtggc cctctcgaag gataacagtt ggcagcaacc taaggctgtt 341880
ctgctccaac ttggaatgaa gaggaatatg atttggccat tcttcttagc acagaggcaa 341940
ataaaaaaaa aaacccttat atacttcaaa agatgaagat cttacttctt actggctatc 342000
tttgcaccag gtcctgggat tggcatataa taaaaaatgc atatgcagtg gccatgaaat 342060
gggcttaaag gtcaatcttg gctgccagtc gtggctaaac tgcattgtat tccatgtttt 342120
tttccatatt gcccctgcag tgtacatata catgcacagt catggcccct gcacactgtg 342180
tacacactca cgcctgcaca catgtatgca tatcaacgcc tgcacatgta cttgtatgca 342240
cactcaccca cacatgtgca tttgtgtgca ctcacttctg cacacctatt tgcatgcacg 342300
ctcatctccc acaaatatgt atgcatgcac actcacgccc cccccaccct cccgtgtgaa 342360
actctgcacc tgcttgtctt taccctcacc cttgaacctg tgtataacct cataaagtag 342420
gaagaagccc agtgttgaac tctacagcct tttacattca aaatggtttt gaaaaatgcc 342480
cattcagagg aacaggaaag caccaaacct aaaaggtctg aggacctttc catgctttct 342540
gtctcctaat ctcagagctg taccaatctg ttatttaaaa attagtcatt atttatccaa 342600
ggcaggaggg gacaaatgta actgttagtt cagtaaatga tttcattctt ttttttttcc 342660
tgtgtccttt ctactgttaa agtgacgaaa atgacaccac ggtttgatat gtggggttgg 342720
tttcagtttg aataatctca tccttagctg catgtgaact catgtcttct cacactctat 342780
tagataaaag cctaaaacag gaaggccaga aacaactgtt tttaaaaagc tcatgctacc 342840
ctggcaactt aagttggaag aacctaataa ataaatacaa agctgcccct ctgtcctaat 342900
gtacttcttc tgaattccag ctgggcacct catggtttca tgcctgaatc acaaaggcga 342960
gtgccagtac ccagccagag cagttttcct accataaacc agtaaatgtg tgtgtatcac 343020
atgtaagtca gggtcagatg gggaaaatca actacaaaac cgcagagaca ttatgcaaaa 343080
ttggattacg tacatgtttt cagttttgtc tcttagcagt ttaagtcttt aattaaaata 343140
cacacgagag agagagacag agagagagag agagaatctg taactgttag attttatagg 343200
ccccggttat gagataatag ccttccaagt aatttttatg ggtcattcta tctagtggca 343260
acttagacta taaagccatc tcccagcttc ccaaaagtaa tgtctgtttt ctcactttct 343320
aataattact tcagatttga aagtaaggag ttgtcacagt gaatacaaat tagagtcagc 343380
ttcagggtat tactaaatgt ggattgtttt gttccgagtt ttatccattt taggcagagt 343440
aacatgatca tttatataca tctgcctcta tgcaggctgt gtagacatac tcagaacacc 343500
agcttcacct cttcagtctt ctaagacagt ctttctaata ctctatattg tctaatagct 343560
aagctattgt taaataaaaa cacgcaaatg tttgcagtta ggctcccccc tccattctca 343620
acctcttaag tgatacagac agtaaatgca ttttgatgtt tatttagaaa gttggcatcc 343680
tgggactgtt cacaagatag ctaatttgtc tgaaggtccc cagagacagt gaaagtcatc 343740
ccaccatctc tctagctgcc ctcataccgg ggaagtaaaa tgcagcatag aacactgcag 343800
ctcacgttat ggagaacagt ggtgctatgg tgatttcctt tctattcaaa tcatttagtg 343860
aggatttaca taatttgcat taacgtgtga ctttcgatca cttatgctgc agcagagtat 343920
tcgttgccta tgttctctaa ggcaccagtg tggtggttca tgtgtccttg tataaaagat 343980
tactgtcctc cccatcccca gtctttgtat ctgtgcacca gaacaaaatg ccctcggatc 344040
atggccaccc aggccagaga atgaggaccc acactttaaa aaccctgtag atgataggat 344100
gagcggtcct catccgtccc ctccctgaga gtgaggttgg gttggagtag aaggatggac 344160
tctgccaaat gatgacagca gccctgagag tccttctcac aggtggccag ctctgtcccc 344220
tccagcctca ccacacattc ccctagtaca caaaggcaga cccgggcagc cactcagcat 344280
gcacatgtag cagtgtcccc tgtacactgg taccctcaag gcctccctgg cacctttgct 344340
tgttacgttg gctgatttct tcaaagggaa atatgggatg tggtgcagcc tggccctcac 344400
acactctgaa aatagcactg cccagggcca ggccttttcc tttgcacact gccataccca 344460
ccctggaaag tactccatgg ttgtatcaca agaaaacagc catttgggca ttttaaatta 344520
ctcaaaatat tataaaaata tttataaaat atattaatgt atatatttat aaaatacaaa 344580
gagtatatga ttaccaggca aatgagtaga cagtgataga actatcataa gaataggatt 344640
ggctattaat tataataatg attggaatag ataacattta ttgaacatgt attatgtgcc 344700
aagcactgtg ctaaaatatt tacatgcagc agttcatcaa aagctcatgg gaagccatgt 344760
gcagtgtcat gcacctgtac tcccagctac ttgggtggct gaggcaggag gatcacttga 344820
gccccagagt ttgagcctag cctaggcaac atagcaagaa cccatctcaa agaagaaaac 344880
aatacaaaaa gctcatgaca gttgtaagac atatgtacca tcattaccct tattcaacag 344940
aaaaggaaat tggggcttag ggtgggtggt taccttactt gtacaaagtc acacagctag 345000
taagtggagg agttggttca atgaaggata accagggaag catctgtggg catatcgagg 345060
cctgaaaata ggaacacctt ggccaaattt cagaccatga catcaagcga atgcttgaaa 345120
gctaaggaac aaatagaaat atgttgtatc atttataaca aattgttacc attaacacct 345180
acaattatta gcgttaggag tattgcggtg ggaattgaac aatgagaaca catggacaca 345240
ggaaggggaa catcacactc tggggactgt tgtggggtgg ggggaggggg gaggggggag 345300
ggacagcatt aggagatata cctaatgcta aatgacgagt taatgggtgc agcacaccag 345360
catggcacat gtatacatat gcaactaacc tgcacattgt gcacatgtaa cctaaaactt 345420
aaagtataat aataataaaa taaaataaaa aaaaggagta ttgcatggtc agactgttca 345480
gatctcatga atgctccctg cttctctatt ccttctttga tttgacatgt gccaggccat 345540
gtattccagt ggatttctgt actttctact ttattccaaa ggctaagcat tcctgaaagc 345600
cacagaggga gttgatgtgc ttaaggaaag aagtatcgct taatgtggcc aaaaaccgat 345660
tccatttctg tacaaatgca aggagttttt gccaggagcc agggattaat agtctagagg 345720
aagggactaa ttgtacacag gaacaatatt tacttttata atgggaatag tttgagacag 345780
tgcatcttct agacacaaac attcagtagg aagggttatg cattaattct ttcatttaat 345840
gagcatttta agcacctatt atgtgccaaa tatcttttcg tagctctaca acagtgttca 345900
cttctcaatc ttttgctaca ccagagcgtt gggaccatgc tcccattaat caccctgtct 345960
caaacaacat gctttacctt cattcgttga tttactcatc cattccttct catagttttt 346020
aacctcaaga gctctgaggt tcagggtgga ataatatgga gggcctttga gaggctaact 346080
tttgaaccaa atcttcgagg atgaactagg gtagtggcag gtagaaaact gcctttatat 346140
ttagccttct ttggtacctg gtcatggatt tcttcttcaa gcatgaatgg catcagttgt 346200
ctgggagtga gatacagtgt tcgtatgctg agaaacagat taggccatta aaaaaaaagt 346260
tgtggccacg tgtggtggct cacgcctata gtcccagcac tttgggaggc cgaggcaggg 346320
ggatcacgag gtcaggagat cgagaccatc ctggctaata tggcgaaacc ccgtctctag 346380
taaatataca aaaaattagc caggtatggt ggtgggcgcc tgtagtccta gctactcggg 346440
aggctgaggc aggacaatcg cttgaacctg ggaggcggag cttgcagtga gccgagatcg 346500
tgccactgct ctccagcctg ggtgacagag caagactccg tctcaagaaa aaaaaaaaat 346560
aagaaacttg taactccctc tctctacttg atgaagtaga catcaggaaa gactttctta 346620
ttctgctttc cattaaaagc cataacttgg aaattattat tgattgggct tggtgtggtg 346680
gcttgcgcct gtaatcccag tgacttggga ggctgaggca ggaggattgc ctaaggtcag 346740
aagttaaaga ccagcctggg caacatagtg agaccctgtc tcaaaagaaa attttttttt 346800
aagtagccta gcatggtgat gcatacctgt agtcccaggt actggggaag ctgaggtggg 346860
agaatcactt gagcccagca gttcaaggct gcagtgatct atgattacac cactgccctc 346920
cagcctcggc aacagagcaa aacctcatct ctaaaaaata aataaaataa tatcttaggg 346980
gaagttgaca aaacattaga aatattgtag ggttaggtgc ctgttgagcc ccaggattta 347040
ttccattatt cactcatatc ttcatgtatc cattcaataa atacttatta aaagcctaca 347100
ccatgcaaga taaaagccac attctactga gtatgcaatg atacacggta tggggtttct 347160
gctttatgga aactaaaggc ctactagagg aattcaggaa ttccagtgtg taccagctcg 347220
gctgtaacac agtgaggaag agataggaac catgaactaa gcggtgaaaa tgtgatggga 347280
ttcagagggg tcagaggtat tggatacagt gagattattt taaacgttta gggtgtacga 347340
gcaagatgag taggagattt ctttaggaaa catctcccta tgaaataaaa gtttatataa 347400
aaggaataat aattacagtt gatatttatg aatacttaat ctgggccagg gactatactt 347460
agtacttttc atgcattgtc tgattaggtc ctcacaacag ccctgtaagg caggtattgt 347520
actttcttat attttatagt ttgcactatt gtgtgctcca tggttatagc aaaagctttg 347580
tctgtaaaag gccacaggga tagaaggcag agaggaaagt agatgtgtga tgcagtatta 347640
attattgagc caataaaatc tctctaattt agatttttta ggaggaagtc attttacatt 347700
ttacattaat ttaatctata ttgagagatc cttctaagaa aataagttgc attacttcaa 347760
gtatacatag ccatataaat tattgaccaa tttttttttt ccaattcata gacattactt 347820
tccagaaact agataatgac catttgttat cagcacactg actgcaaaat ggatgatgaa 347880
gaaagcctgg gttttttttt tttttttttg aaagcttggt agttcttctt gtgaataaat 347940
taaacacttt cctgacgatc ctgtttgcat tattgactta tatgtactgg ctcatatgta 348000
gctgcccatg tataattctc cccactcatt ctgaagggag ggaaaaaaac gattaaaaat 348060
ttcccctcct tctttttcct gttttgagat tatttttgct cccagcagag gcgcggagga 348120
gggagctctc agagccccat tctgttccct acctacagca tgaaggatcc agataaccgc 348180
agaatgaatg aggtttgagc atttgttttt gctataagta agatggtttc ccattaataa 348240
aagtggcact cagtttactt tgtcttcgcc agacaggcaa agggtaaatt aaggtggtta 348300
cctgtggtgt cccagctctt tcccaaggct ggactagtgt gagccgagaa ccaggcagga 348360
ctcactcaca ggtccctttc tctgctactt ctgctctggt tttatgcgaa gccctatttc 348420
ccagctgctt cgggtaaaca aggacttctg tgttgaaata ataaccactt gggctgggcg 348480
cggtggctca cgcctgtaat cccagcactt tgggaggcca aggagggtgg agcatctgag 348540
gtcaggagtt cgagaccatc ctggccaaca tggccaaacc ccatctctcc taaaaataca 348600
aaaaattagc cgggcatggt ggcaggtgcc gtagttccag ctactcggga ggctgaggca 348660
ggagaatctc ttgaacccag gaggcagagg ttgcagtgag ccgagatcgc accatttcac 348720
tccagtctgg gcgacagagt gagaccctgt ctcaaaaaaa ccaaaaacaa acaaacaaaa 348780
aaaccactta ttgtttcact gcctaatatt aattaattgg ccaaatttct attttattat 348840
attccatata ttttaaaata atttcttctt ctgttgtaca aaccaagata gaagataatt 348900
tgcccaagaa cacaattggt aggtatccta gctaggaaag tgggtgcttc tgaaaattat 348960
aaaaatgaaa tgaggtaatt ttctgggccc ttggtacaat gcctgagatg tcatatatac 349020
tcagctaatt ataagtgaca ttttgttcta gaatccagta gctcaacttt tagtccattg 349080
tgctgaacac aaatctatag atccttaaat tgtatacttt tattaattta attttaaaga 349140
gccagaaaaa ttgactacat tggaaacatt ccagtccacc aacatattga gtagaaagaa 349200
ggacaaaggc catattctct ttcagatgct acaaattgtg tatattttca gtaagctgtg 349260
tctgcttaag gaggcattac tgcattcgga tagataaact caaataaaaa ggcctgagtg 349320
aagaggctct actgggttta gcgttttttt gttgttgttg ttcagttttg catgtgtgtt 349380
tttaaatcag tttatggttc ataagctgat gaagcagtga gtacaagttt gaactatgag 349440
aagcaggttt gaataagtct agacatttgg ttatcttctg tctagcattc atttgtgtcg 349500
tgggcgtcac actctgggga ttagtgtttc attatgcaga agctgtttta tctttagctt 349560
tcttataata gcttaaagtg aattctgagt ggagagagaa tgaaggccag gccttagtaa 349620
ctgcaagaat cataccaaaa tgggttggat gggttttaac agtgaccgat aagcattacg 349680
acctcactct ctgatagttc agttggctcg atgctgtctc atcacctcat ttagggtaca 349740
atatgctgag gaactgacca aaggtccctg aacagtgaga gatagggaag agcagaaatc 349800
cgttcctgta ccaagtgtct aacacttaat ataggtgaga gctggcgtga gattatctgt 349860
gctgtggaaa aatgaggacc tatcgatacc tctaagtata taatcactgc cgtgtcacat 349920
tttaattagc tccttgaggc tatagaaaga agttcgcttc ttatcctcca aattaagcat 349980
cacttttaca aacaatcaat gttccatttt caaaacccca agtagagcaa tgtttgattt 350040
tccttacttt ccagctttga gaatgtttca tttttagaaa tatgttatag gaatgtaaag 350100
taactcttgt ttccccaaat aaccacctcc ttattatctg ttcccctaag ctgaatcctt 350160
tcaaaggaaa ttttgtcttc aggctaagtt tagtggctga tggaaatcaa aattatatca 350220
ggtgggccat tgcgtcagta aaaaagccca gaccaccacc acacaggatt tttctccaga 350280
cacccaaaca tcatgtcaca aagctcaaaa aagtagtgat taacatgcag tgctttcagg 350340
aggcccacat tgccgattca gtcccagtat gggctcgtca gtttcacttt cattcattca 350400
tttatttatt tattccccca cccattgatt cacattcact catccattca ttaaacattt 350460
gctgcacaca atatcactgt tagacagact ttcagaaatg attgggttcc tgtattacag 350520
acatgagccc acggcacaaa ggtcaaacta agagtaagat ggatgtttat agcacaagcc 350580
tataacaaaa agaatgggtc ccgagccgca tcttcttcca aatgcacaaa ctatatttgt 350640
accttaaaaa aaaaacaaaa acagtgtttc cttttgagag gcagcatggt atatgggaag 350700
aacacggatt taagaactag acaggcctgg gtttgaattc tgcatccata atgtgctaac 350760
tgtatcattt cgaggaagtt cttttgagtt tcagtttgtc tttaaataga gtcatcattt 350820
ctactttgta gggttgtgtg aggattaaat ataaaatatg cagcataatg actggcacat 350880
ttaaacgaag tgctcagcaa gtgctatttc ccttcccctt tcttcatttc taacatagtt 350940
tgggaatggt ttaggatgac tctttttctt cttgtgaata gatagagacc tcatcaccct 351000
aacactagaa aactatagga cagagaccat acttcttgct gtggccagcc ctcatccact 351060
ttgatgatgc ttgcagctcc caagagagac aacagccccc acggcatggc caagagagga 351120
gcaaactctc tccccaaggc agtcactctg gggatgccat tgttccattg ccaaactcat 351180
gacctttggg gaatttggaa atctactact ttgtggggag aaaaggacaa agaaagtcaa 351240
gattaagctt tatatgtaaa ggccttttat tttaatggtg ttgaattgag tttggatttt 351300
gcgtaccctt caaatttctt agggtgtggg tgagggcatc ctaggagatt taattagctc 351360
cttgagcggc actgaagttt gcgacattga ggcacatttt cttctattgt ccattgaagt 351420
gggggagcct ggcaatgaaa tttctgagaa actgacgctg ttgccgtgga tagaattgta 351480
tggatatttg aatttagttt agtcacttgg tggagtttta ttttgttgtt tggtttcttt 351540
tggaaagaga aaattagtat agtatgaatc tgagcagtct ggttacatgc tttaatgggc 351600
ctctgagata aagcagaaaa ggatgtagtc tagtagtaac cctttagatg ataagggaca 351660
cgcaggaggc tgtccaagac agtctgttaa tcttaatagt ctctcacttg ttaagacctg 351720
atttatttca aactaaattt cttgttttga gtttccgggt gaaagttctg gactgaatcc 351780
ctaaaaacat gcacaacaaa gaagaaggct tttagaaagg tttctcctat tgacagggtt 351840
catattctat agttcacaat tcagtgaatc aacatttata ttaatttcat ccgttacaac 351900
ctcagaattt gcctacaaga tccaatggca tttttactgc ccttatttag caagcctata 351960
cagtacttca tgcacttggt catgtcttca actaatattt attgggtgtc ttccctaagc 352020
aagatagtgc gagagagaga gctgagttaa aacattcaag ataacctcaa gaagctgaca 352080
atctactaag ggagataaga catacatatt aataagaaca acttaaacac aaaggacaag 352140
atgatatgtg gcatatctta tcaattaaat aatgttggac ttcagagggt gaaggaatta 352200
ggcatgaagg tatatctcaa cagggctgtg aatgactgga aacaaggtct tctctcttca 352260
cactgtgagc cagccacatc catactacgg tgacattcat ttctccccca ggccagctat 352320
gggcagaagt ttaattatcc ttgaacgtct tcaatgatcc tcatctttgc ccttgttccc 352380
tctttatcct ttctttctcc ccaatgtctt aaatcctgat gcagccaggg agattttttt 352440
tttttaacct tcaagaaggt aaaaaactat gccagggcaa aatgccagat caatgttgct 352500
attaatataa tcagatataa actttttcca gttggcacca acaaccctgg gccttctctg 352560
agtaccacct ataaacaggg cttcaatttc ccatttttgc atacttacta atgtactaca 352620
gatcttgcac tgactttaat tcaatatcaa tattaaagtc atatgaggta gtagtaaata 352680
gagatagcca taccttagag tcaataagac ataaaattag ttatgttatt attattatta 352740
attatgcata atatgtcatt ttcctgaaga gaacagacta atagctgatt tcagcaagca 352800
tctttaggct tttgttttca aattatttta catctttttc ttttcttttc ttttcttttt 352860
tttttttttt tttttgacac agaggtctca ctctgtcacc caggctggag tgccgtggtg 352920
tgatctcagc tcactgcaac ctccgcctcc caggttcaag caattctcct gcctcagcct 352980
cccaagtagc tgaaactaca ggcatgtgct actacacacg gctaattttt gtatttttgg 353040
tagagacgtg gtttcagcat gttggccagg atggtctcaa actcctggcc tcaagtgatc 353100
cgcctgcatt ggcctcccaa agagctggga ttacaggcgt gagccactgt gcctggccac 353160
ccacctattt tccatcttta gcactggccg ttctcattca aaatacgtac tgctacacta 353220
agaggagact taacttcaaa ttcactttgc tccacggatg ttgtatatga cctgaataga 353280
tgtaattctg acaagcttgt agttcattgg aggctcacaa tttgaaagaa atgcatgatt 353340
aagactttag aacataaaga agattctagt aaaacaaatg attgcaccct tttggatttt 353400
ttgcatatta tctttatgta gggaagggaa tgatatgtta gaaagaatcc tcaaacaggt 353460
ttagacaaat cactggttga accataatct ccaaaatatc gctacatcag aaaaagccca 353520
acatagcctc tgaggtattc gtcagaaatc ccagtgcaag cattaggaaa gaaatgtact 353580
ccctgctcct cacctttgta agtcagattt agtcttcact gttcatttca ggttctctgc 353640
ctccataggg gtcccttcag cacttgtttg gttctctaat tggcttatga tagtgggtct 353700
tacatcatca actggattgt aaattccttc agaaagagat gtcaattaag tacacagcag 353760
agtcacagta tttcaaaatt ggaagtcata gtaaggggga aggagggccg ctagatgctg 353820
tgattcacac ggcgtcatag taagcaagag gccgaggcag tgccagcacc caggtagggc 353880
tccggtgcca ccctctgctt catcctctgc caagcctatc acgacggtcg ttcagctcat 353940
gctctccatg cacgtctggt gatttgatgc tcatctttgc cagcttcaga gcatcactgg 354000
acacatgccc agtcttgaag ggttaatttt caagtaccaa gcatgctttg gacaaactca 354060
aatctgttcc ttgttttcgc tcaacccgca accagcatca tcagcccaga cgcagcttcc 354120
ccagaaggcc agcaggtgga gcacagtttt gtggaacttc tctagaactc gctgtttaaa 354180
agccgcaaac caagacatgt gaggctgtgg ggtggggggc aaagaagagc cccagattct 354240
gcacgtctgg aagcttttaa aattgtctta caacaatttt agacctacaa aagccagctt 354300
ttgaaattgc ataaacggca agtcgagttc tttttttttt ttttttttga gacctagtct 354360
tactctattg cccaggctgg aatgcagtgg cacgatctta gctcactgta gcctccacct 354420
cccaggttca agctattccc ctgcctcagc ctcccgagta gctgagacta caggcgtgag 354480
ccaccacgcc aggttaattt ttgtattttt agtagagaca gtgtttcact atgttggcca 354540
ggctggtctt gaactcctga ccttaagtga tccacctgcc tctgcctccc aaagtgcttt 354600
gattagaggc atgagccacg gtgcctggcc agcaagtcaa atttttaatt agacttaaaa 354660
tgttggtgct cataacaact acagttactg tggttttttt tttttagttt cataaagagg 354720
acagacgcta aggcaattgt gtggaacaga gcagcttctc ggggtaacca tctcctgctg 354780
atgtataaat atcggggcaa aactgagtaa gttttagaaa ataaatgtca aagcaagtcc 354840
gagtcattta ttccttagca ggaaatatcg atcctgtgac attatttgat tataatgact 354900
gtttctatta ggttaaatga ctgaggtata cttaaccagt ttaggtgaag aatgaggctc 354960
attgcaccat ttgattgact aaaccttaga acccatgtat tctttttatt tgttcagtca 355020
ccaattttta tgaagcacct actgtgtgcc aaacaccctc ttgggtgcca aggtaagaat 355080
taaattttgg aattaagcaa agcatgatgg ctcatccatg tagtcccagc tactcagcag 355140
actgagacag gaggatcgct tgaacccagg agattgaggc tgcagtgagc taagaacatg 355200
ccactaccct ccagcctgga tgacagagac ctcaactcta aaaaacaggt tttttaaaat 355260
tggaattaaa cacacttggg ttcaagttct acttcagcta cttattagtt gtgagaaaat 355320
aaatgtcaaa tgtttttcaa tttgcataag ttatttaacc acattatcct tactttcctt 355380
atcattaaaa ccctgaaaag gttgtaagtg acaaaatacg tgatacacac ttagtgcctg 355440
tcagatgata ggcctgagtt actgttaact tttttttttt tttttaccat cctcatcatg 355500
ttcctcattc tcatcttctt ccagggttct cacttgatga aggaaagtat ttaagacaat 355560
acttctttaa catacttaat aatggaatgg atatagaaat gggagaaatc agtgtgaaag 355620
caggctttgg tgaggccact atttaaaata actatagttt atttaaagga gacacgaagt 355680
aactgagatt tcacaaggcc ccagaccccc ttctcgaatg ttattatcaa ctcccgtttc 355740
tgccctgtga tgtcatgagg gttgatgatc ggttcttctt ttattttgtt gccaagtaca 355800
gcagggatat gtgtcctctc tattcctgag tggtgaaagt tctcttctga gaccacaaaa 355860
catggtggcc tcaggttctt tatggcccca cggtctcttc ctgcacccct ccccaagggg 355920
ctgggttggt agatattcct aatgttatat cccctgttgt tgacaccccc atgcccccaa 355980
tcccgcatgc ctagcagatg caccttaacc caaccactct gggtcagttc cttcctcaca 356040
cagcaagctg ctaagaaggt tgaagaatta ctggacttca gataccacat ggcaccatta 356100
tccctggcag gtttcctgtc actgcctgtt tctttttctt ccaggaggct catcaaacag 356160
gcctccacac aaacagaaca tccatccact tcacaggcca cccagacgta tccagagatg 356220
cccagatgag acctgatttg cctgggttaa ccgtgtgtct gcagctcaga ccctccaatg 356280
gggcttctag ctacatagtc taatgatgaa aagctactgg cctgggattt aagagcacag 356340
ctttctagcc taactccaca actgtgcccc tgggaatttt agtctcctct ctgcatttca 356400
acttcaccaa ctaaataagt accttttaat atctaattga attgatatgc tatataagca 356460
aaccagatgt tgtgagtaaa accagcttca gcatccaaaa gttgatacag atacttttga 356520
ggagcatgtt tcaacatatt ccttaggaca gccttactat gagaaggtca tctctcagtg 356580
atttcaatgt gccattggaa gaagagcttc tgccatttaa atgtccagtt aggcactggt 356640
ggacacagca gtatccttcc cattcattcc gaccatatta ttttgaatca taaaggcata 356700
tccttagagg agaacattta aaaaatttaa taatgtattt gtttcattaa catgaagtta 356760
agactttaag ataagggtag tgcccacaac acaatctttt aaaatgaagc caagttaaca 356820
gtcattactc tgtgatctca ggcatgccca ttatctctct gagctataac ttcctcatgg 356880
atgatcacta gtctcctgcc gctgtgaact tttacaaatc tgattccata gtacacatct 356940
taagtgttag aaatgcttgt tctttggtgc tgtaaagaaa tagaccttga acataaattt 357000
aatttcctca gcaagaccat ttttactttc tgcagaaagg gtacacttgc cagcagtttt 357060
gccacaagag tacacggaac aaaggagaca gggtcattat aacctgacgc gtccacccta 357120
ctgctatgtc cagtttccat tggctggaat gggacctcac attctgtatt tgtcccgaat 357180
ggctagcagc ttagaacttt ttaaaagcag caaaagcaga agagaacaaa ggaaggagga 357240
agtaacttgt gaaatgctga gaaaggtaaa aaaccttcaa ataaggaaga ggaacaggct 357300
atgacctaat gcttgcttgg accagtataa gcatgctagg gtaaatattt aggctaaatt 357360
gtgggagcta agaacataaa gtacattgat ttctttatta cagctagcag atatttaaga 357420
atgttagcac aggtctttga ataaattttg cttctaagag aaagtactat taattcctaa 357480
ttagatgggg aggaaaatct ttgaagagga acctctactt tactttttac attaaggaaa 357540
tagggtgtct agtaatgccc tcaaaagtta tgaatgcccg gtatccgtta ggtttgaact 357600
aactgatctt cacattactt taaaaataga gatgactcaa ttattggttg gctgtgagta 357660
aaaccaaata aagctttatt taaagtttta tttagattct tgaaaaaatt atttaacttg 357720
ggttctcctt ggtatgatta atttagagag aaaggaatct gagaatgctg ttgacctcat 357780
cattccttca catgttccac ttttttagtc tctcatttta acttaatgaa ggaaagtcat 357840
agggagaaaa aagagagaga aaagaagata aggctgtgaa gagagagggt tgttttaaga 357900
cctcacgttg aacaatcagc taaatctgca ttgaaagcaa gagaaatagc tcaaacacag 357960
gtttatagta ttttctttct gagagtgaac attgtgcagt aaaaggtcct tcacatgcta 358020
tggttcatac actggcattt catgaagcag tagggagcag agttaacccc accaagagca 358080
ctgcagtgcg gccttccttc ccagcccccg ttccagcacc tctttccatt tcccgacttt 358140
tctttcaccg ccagtaaatt taatgtcttc agctgagcac tgatttcatg agcgtaaagg 358200
acattagcag tacttcgcac atggtatgca caaatattag gcaagtccaa ggacaggatg 358260
agctgcaagc agtctatgat aagagtcaaa ggcaggagtt ggggttgtag actcctccag 358320
ccaaccacag caaccaggaa tttggatgct tcggccgcca gagtgcttgc aagagttcat 358380
ctctgaaatc gcttccattc cagcgctaac attttatgaa acctgtgctt ttcaaacaga 358440
ttgttttatt gcttcctgca tcaccaatgt gttttctctt tgctcccagc tccctgagag 358500
cattttgaat tatagcacag atcattgcca tccacaaggt gcatgacatc acagtggact 358560
tgggggaagc aatgtcaaat gagactgagt ggaatgggaa ggagataggc tggaaaattt 358620
aaataaaggt ctttaggata aaatacagaa tccagaatag ttcctaactc tcactacgta 358680
gtcgtttgta gcaaactgct aggactcttg gcttttattg gtgtgatata gatgcgctgc 358740
tccttaatgg tagagactgt gtctttaatc aaaagttggc tacagagttg tttgtgcctg 358800
tgatatactt attagtccag agcagatata ttttctgtcg tgtgtgctga ggagcactga 358860
tgtaaatcca cttaatgttc atatcaaact ctattctcca ggaaaaggtg agggactgaa 358920
atgtacatac ttgttggctg gtcacatttg atattcagag acccaaatga gaaagtcttg 358980
cttctgagaa agtacccaaa caccaggaca tcttccaagc cccacacagt agcattaatg 359040
ttttaggtgt gcaataaata gtgctgaatg aaggaagaaa gtttcccagg ctagaaacag 359100
gtgagtggag acgtgattat tattaataca aaatctggtg tgaggtgggg gtgggaccct 359160
ctccccaggc tgtaccgaca gccccttgct ctcagtcgga ctcccaggct gagatccggc 359220
cactaaagag ggaacagtga catttcacag gaaatgaccc agaaaactaa caacgtggag 359280
tgtgtgtgcg tgtgtgcgcg cgcgcgagtg cgcgtgcatg tgcgtatggt gcacatgtgg 359340
tgggggctgg ggacagcttg aatacaaccc agggacctta actggaggaa agactttacc 359400
aggcagactc tggtaaaagt cgagcaggaa gctgagcgtg acaggaaccc caagggtgtc 359460
aaaatgcccc ctcactcagc atctcttgag tcccatcagg acagaacttg tgcttagtca 359520
ggttctggac ctgacagatg tgaaccagac gccctctcat tgctgggggc tctgggaggg 359580
aaaggtggga tgaagagggc acattcctcc caaaggacaa agcacctttt agtggaaaat 359640
gtgaaaacaa aacatgctca gttcaaacaa ggctcacttt ggtccagtac ttcctttgtt 359700
atgttcctgc ctcttaaatc tttctgcttt aaagaactct ccaagaaaat attttcagag 359760
tatacttttc agaggccctg tggaagccaa gaataaatgg cctccttttt tgggtaaaga 359820
gtcatatgtt taagatagtt ttatttgctc cccccacctc ctgccccgca tgcacacacg 359880
ttgatatggt taactatctt ctgctctgaa tcagtattaa gaatgggcac agagatgact 359940
aaaagccaga atttaccata ttatcccaca aagcagtaac ttttcaattt taggatacat 360000
aatttcagca tttttcctat cactagatgt ttagagctcc ctccagtgtc tctatattgt 360060
catatttact ttgagatttt tttttttccc aaagatccta agaattcttt taaccatagc 360120
agggagagta tgttattgtc tttaagctta cttcaagaac agaacgtgaa agccagaaat 360180
atcacatgca gccccacaac ctatagattg tccattcctg ctgtctgtgc tttttttcag 360240
gatgaggaga gttttggagg tagaagaaga tgaagtggtc agaggatggg actcaggagg 360300
ggacagggta ataaatatgg tatgaaagtt gctgcattta aagagcttag ggccgggcgc 360360
catggctcac gcctgtaatc ctagcacttt tggaggccaa ggtgtgagga tcacttgagc 360420
tcaagagttc gagaccagcc tggccaatgt ggcgaaaccc catctctact aaaaatacaa 360480
aaattagtca ggtgtattgg catgcatctg tagtcccaac tacttaaggg gctgaagcag 360540
gagaattgct tgaacccaga aggtcaaggc tgaagtgagc tgagattaca ccactgcact 360600
ccaacctgag tgacaaagtg agaccctgtc ttaaaaaatt tttttttaaa gagcttgaat 360660
aacttcctct tcttagaaaa cgcataaact ctgatgtgtc agctgagaag ccgaggacct 360720
gggatttcaa cctcttgccc gtgtgtttgt gattctggcg tgaaggtgat gatgcatttc 360780
caaagttgaa cttggtctgc taggtttggg atgtggcaga attctggttc ctgccagagt 360840
cccagtcttt ctgagtgtat gtgtgtgtac atgtgtgtgc atgtgtgacg tatgtattta 360900
tatccataca tacatacacg tgcacatcta catgtgtatg tatatataat caagatgttc 360960
aaaattcaaa gcgctgtttt aagagagtta aaaaaaattc actatctaca gatttgaatt 361020
cagactgggt taaaaccacc ttcctcctct ggttgtcaag aggaaggttt tggagttcgt 361080
gaattttttc tgtggagtta agataacgtt tgatgtagga gagcaaagct gcttcccatg 361140
cctaattcca taaaaagccc agaacctctg aggcccatct tcagccaagc agccttgccc 361200
tctggccttt tctgcaacag tgagacaaca gccctgggca cagcgggagt tggttctgac 361260
accagatgtt ctctgctcct ggttaatgtc agtgagggct ggaagttgaa taaatgagaa 361320
caggagtggt ctgggcccat gtaaatgatc ctcccttgaa aggaggaaca gctttcatca 361380
tttgttccag ctaagccttg catgcattat agatctggtg ctaagcagtg ggaaagatct 361440
cataagtaat gttttatgtt ctttctgtct ctcctcttct gttgttcttg gcttgtgggt 361500
tgtgttcgtg ttgttaactg gaaaattgct ataagccagt tgtctcgtaa gttttaaaaa 361560
cgaattagaa aaaccataaa atcctctggc ctatgcacat tgtccctgtt ttgtgaaaac 361620
attaaagggt aaataaaaag gaaggagaac agtcaataat gtgcatcaaa tatattctga 361680
gttctagaga aattaatgac caagcattag aactagaagc aaaaaaaaaa aaaaaaaaaa 361740
aaaaaaaaaa aaaaaaaact gtcagtggtt ggcgagaagt cttgtttttt ccagccatat 361800
agatcaactg atgatatggt ttggctgtgt ccctgcccag atttcatctt gacctcccat 361860
gtgtgtggga gggacctggt gggaggtatt gaatcatggg gggcaggtct ttcccatgct 361920
gttctcgtgg taatggataa gtctcacgag atctgatggt tttaaaaaga ggcattcccc 361980
tgcataagct ctctctcatt ttttgcctgc caccatccat gtaagatgtg acttgctcct 362040
ccttgccttc caccatgatt gagaggcttc ctcagccatg tggaactgta agtccaatta 362100
aacctctttc ttttgtaaat tgctcagtct cgggtatgtc tttatcaaca gcataaaaat 362160
ggactaatac gactggtggt tgagaaaatg tagcagcctg agatttaaga aacaagtgat 362220
ccctgagaca gagcccttga ccctaaaggg gaaaaatatt cagttacact catgagatat 362280
aaacatagta cttttgttgt aactgctgag aactgaagag ctaaaagtca acattatttt 362340
cctttttgag actcaaagtg tgtccaccag gagcactctt cccaatggag gcaaaatctg 362400
ccaaagttgt ttttgttgct gtctaacctt agaccatttc atctgcccca actaaaagtc 362460
ctagccacag ctctctcaag cgattctcca ccctcagcct ctgagtagct gggactgcag 362520
gcacatgtac cacacccagc tatttttttt aaatttttaa attatgtttt ttagagtcaa 362580
gggtctcacc ttgtttctcc ggctgatctt gacctcctgg tgtcaagtga tcctcctgcc 362640
tcagcttccc aaaacaccag gattacaggt gtgagcctgg tcccccaggc ttgacttggc 362700
acattgaatc ttttatgaag aacaattaat gacttcccat gttgtgtaaa gagacgggca 362760
aatgtggctt caaagcaagt cttgccaacc ctcgctacaa ccagactgtc cctggcctaa 362820
gcaagcccct cccatgtaga cctggaaagc cacttccagg tttcaaggat gagttttaga 362880
aaattaatgg ggtactagca tatgtgggtc aactctttat tttaatgtaa ggacactgga 362940
cactttaaaa taagttttct aatcttttta aaaaggaagg gatattttaa catccccaaa 363000
gtgaaaataa tataatatca gagtaagtcc tagaaattta atattatggt acatttacta 363060
tgttgtcttt atttttcttc atttccacgg attggccctg gttctcagac cagcatgtgg 363120
gaactactgg gttggagtgt tagccaataa aaatggccaa aaagtagacc atgaccttct 363180
ttgagctttt ctctggcttg taattcccga agctccttct agtgccaaaa tacttctccc 363240
tccctccctc ttttagactg taagctcatt gagaacaagg acaatatggt aatcttaata 363300
tctttagcac acagtcagat atgaaagaga cacatcataa atattggatt aacaaatgaa 363360
tgttctgaag gggaatgtgg ttgttgccac tgtagaaaag gttcaggaac caggaattct 363420
tgtgtaagat gtcatccaca tagtcactgg agaattccac agttgggttg agggcaaata 363480
ggaatgccat gatccaggta cctagaactg gcttgaaaac ttgtaccttg caacaataaa 363540
tggaagccaa tggccatgtg gtctggccat ggccacgtgg tcagaagaga aggaattttc 363600
gaatgaggat agaggaagta gccacggagc cctgaacagg ggcttgggag gttgagctct 363660
ctccacctca gagggctgta ggagaaacag ggctgtctgc agggagccaa ggttacagtc 363720
tgggttggag agaatgttct gaggaaaggc tgaagcaaga agagagctac tttttactag 363780
attactgtgt attcagaggg cagagtggaa ataattaata ctgagtgaat agaaggacag 363840
acagacctaa ggataggtga gagaggtctg tctggtgctt ctgaaagttt caagtgtcta 363900
ggaagccccc agcgttctag tggaaatgca cattctggtt ctgtcagtct gggtgggacc 363960
tgagattctg catttcccac atgctcccta gtgatgctga tgctgctggg ctgtgggcca 364020
tggtgaggct agcgtttagg tcaaggaaac aagcatcttc agaggatgtc ctccaggagc 364080
ccaggcaaca gttagaaggt caatggaaaa ttctctggct gcagctgatc ttttctgctt 364140
ccctttagag cagggaatct caacagcact gttgacattt ggggcccaga tcatcctatt 364200
tggggaagca gggagatgga gggggtggag gtgtcccgtg cattgggaga aatttagcag 364260
cattcctggc ctctatgcgc tggatgctgg tagcacccgg cagttgtgac aatcaaaaat 364320
gtcctcagac acttccaggt gtcccttgca gagcaaaatt gcttccggtt gagagccaga 364380
gggttagaag gagaattatg tgtcttccct ccccgcttgc tgccacctcc acctcttgtc 364440
ttctagaacc atgaggcaga aatgacttaa gtctgatatg cttggaacgc aacactcttt 364500
tcgctatttc tgtctttaga aatgttgaga aagtgtttgc ctttatttga cggcctgatt 364560
actttaaggt gtcctcggca tagaccagtg agcgccttgg ccctatttgc tgacagtttt 364620
aatagaacag cagggaaagt cctttccaag aaagtgttgg ctacgtagcc taacgtcatt 364680
ttaagtcatc accatacacc caccaaacct ctgagataaa atggaaactc catcatctct 364740
tgccagggta atggtgttag taattcacta gtgacctcta agaatttctc tgtgcattca 364800
ctgccacatt taacttttgt tacacggcct ccaaaatgtt ttccagccac aaggtcagtc 364860
cattgacaat ctcaaaaatc ctgacaaggg gacagatggg tttagttttt gcctttgtga 364920
tggttagttc tgcttaatgt gttgagaaaa catctgaagg ttttaaccct ggctggagtc 364980
gtgagacgga ggcatgttta atggaatagc acacgatcgt cctctcatgg tgagtccacg 365040
ttggagggcc caaagaccca tgttgtacaa tcggttcaac tttttctgaa agccaaagaa 365100
aacctacctc caaacaggat ttagtctcaa gctagagcaa aaatgtacat catgttgaaa 365160
agtcttctcc aagtgctaca attcataagc agtgttgtgt ttttactgga aaagcttgcc 365220
atctagccaa gcattcttca catttttccc aggatttagt cataaaatca ttttagacat 365280
attgcaagga taaaatgtgt acatatctga taaaaggcag ggattttttt cttctttttt 365340
gctgtataac tcctggagga ggcgaaaaac aaactagaca cacacataca cactcacaaa 365400
acacacgtat ttgtgcatat gtatgtgtat atagagagtg cacacatgtt catatatata 365460
cgtgtatatg tgtatgtata tagtttgttt tccccctcat gaaatgtgtg tgtgtgtaaa 365520
ataaactcta tacacatata catatatatt attttcacca ttaagtgcaa gaacttggat 365580
tctttattca cgattacttc tatttgaatt taaattagat gccttaggct tctctttggg 365640
tttgaataac ttagacacaa agtataaaac acttcctaat gatgcccacc tgcctaggac 365700
atctttagga attcaggtgg aagtgtgttt gcatttgatt tatctaagac gttgcagcag 365760
tggggatgta atttctgcct ttgggcagga agggagctta gatggtggag ttcgtatttg 365820
taaacgtaga tgtgggtgcc tcaaagttgg ctgcgttgct aactaaagga aggagagaag 365880
tgagcccaga tgttgacctt ttgaaaaaaa agtcccattt tcatgacaga ttggcataaa 365940
agcaataacc tgtggtaaag tctaaagaat acaagatttg gatttctgga tttgagtcct 366000
gtctatgcaa cttactagat atgtggcctt ggacagatca cctaatctca cctgtcaaac 366060
agggacaatg aaactcaaca tagcaatggt tgcgaggagt taatgaggta atccgtcaaa 366120
ttctgtggcc gtggtgaagg atgatacaaa tatccagtgg cgtttttgtt cttgaagata 366180
gtattcttgt gtgagttctt gccaacacac atacaattac atttctgagt cagactgatt 366240
tcagtagcag ataaacagag ggagtaaatc agcaatagat tagttggaaa ctctggacag 366300
caatgatttg gtggcatatg gcttggtggt atgtacctgc acatgtaatc atggaaagtt 366360
gactattcct actgttctcc cctagttcta tttcacttaa gaaaaagttg gaatggatac 366420
cagcagtgtg ctgataaaag tttagctact actggcggcc gggcacagtg gcactttgag 366480
aggctgaggc aggcagatca cctgaggtca ggagtttgag accagcctgg ccaacatagt 366540
gaaaccccat ctctactaaa aatataaata ctagccgggc atggtggtgg gcacctgtaa 366600
ttccagctac tcgggaggct gaagcaggag aatcacttgg aggtggaggt tgcagtgagc 366660
caagatcgtg ccattgcact ccagcctgga tgacagaacg agacttcatc tcaaaaaaac 366720
aaaaaacaaa aaaacaaaaa acaaaacaaa aagtttagct actggctcgg gaataacagg 366780
acgtttgatt tgtagcattt actgatttct gtaatataaa tactctcact gtgactaatt 366840
tcaaactacc aatgtgacat taccaaccat gagattgtaa agagatgcac agtagcacac 366900
caccatatag gacagtcgtg catcacttaa taatgggaat gcattctgag aaatgcatcc 366960
ttacatcgtc cttctgcaaa tatcataaag tgtgttcacc caagcctaga tggtacagcc 367020
tgctacacat ctaagctata taatgcagcc tgttgctcct aggatacaaa cttggacata 367080
gggttacgat tgcctacagc actcagcacc ttactgtact gaatactgta ggcacttgta 367140
acacaatgtt cctaaacata gtttttgtgc atctagacat agaataggta cagtaaaaat 367200
gaagtagaaa agattttaaa agggcacacc tatatagggc acttaccatg aatggagctt 367260
gcaggactgg aagttgctct gggtgagtca gtgagtgggt ggtgagtgaa tgtgaaggcc 367320
taggacatca ctgtatcact gtaccccact gtagacttta taaggactgt acacttaggc 367380
tacactaagt ttgtttttta aattgttctt tctttgataa taaattaacc acgctcagct 367440
tactttttta ctttataaac tttttaattt ttaaaaactt tttgataact ttcataatag 367500
cactcagttt aaaatacaaa cacattttac agctgtacaa gaatattttc tttctttata 367560
tctttattct ataagcttgt ttttgtagaa actaagtctc actatgttgc ccaggctggt 367620
ttcgcgcacc cgggctcaag ccatcctcct gcctcagcct cccaaaatgc tgggattaca 367680
ggtgtacacc accacatcca gtttataagc tttttcttat taaaaaaagt tttttttttt 367740
taagttttct gttaaaaact aagacacaaa cacatacatt agcctagccc cacacagggt 367800
catgatggtc agtatcactg tcttctacct ccttatcttt tccatctgta aggtcttcag 367860
aggcaatacc atgaatggag ccatcatctg cgatgataac aatgccttct tcttgaacac 367920
ctccagaggg acctgcctga ggctgtttac agttaattgg cttttttttt tttttttttt 367980
tttttttgag acggagtctc gctctgtcac caggctggag tgcagtggca caatctcagc 368040
tcactgcaac ctccgactcc ctggttcaag tgattcttct gcctcagcca cccgaagagc 368100
tgagattaca ggcacgtgcc actatgccca gctaattttt gtatttttag tagagatggg 368160
tttcaccatg ttggccagga tggtctcgat ctcctgacct cgtgatctgc ccaccttggc 368220
ctcccaaagt gctgggatta caggcatgag ccactgcgcc cggcctacag ttaatttctt 368280
ataggtagaa agagtccact ctcaaataac aataaaaagt atagtatcgt aaatacacaa 368340
accagtaaca tagtcattta ttttcactat caactattat gtactgtgcg taattgcatg 368400
tgctatactt ttataggact ggcactgcag gacgtttata tataccagca tcaccacaaa 368460
catatgagta atgtattaca ctattacatt ggacagctac agcatcagta ggcagtagaa 368520
aattttcagc tccattataa tcttatgtga ccgctgtcac atatgcaatc cgcggctgac 368580
ccaaatgttg ttatgtggtg catgacttta tatccactat acaagtagat gtaattaacc 368640
tcagtcatac agataatagt aaaatagagt aaaatgaggg atgatgatga gtttttgttt 368700
ttgttcttgt tttttttttt tttttttttt gagacggagt ttcgctcttg ttggccaggc 368760
tggaatgcaa tggcgcaatc ttggctcacc gcaacctcca cctcccgggt tcaagtgatt 368820
ctcctgcctc agcctcctga gtagtgtgat tacaggcatg agccaccatg cccagctaat 368880
tttgtatttt tagtagagac gggatttctc catgttggtc cgactggtct cgaactcccc 368940
gatctcgggt gatccgcctc gcctcaggag tttttaatat aatttattaa accataagtt 369000
tatataagtt aatttttaac attggctatg ttgaacgctt ggctgtcaag cttaactgtt 369060
agctctcaca gacctggctc caacatgcta ctgtttctcc ttggctgtgt tacagtacaa 369120
agttatacca tgaattagca agttcaggac catcctggaa agccagcgtg gaaaatgcag 369180
tcataaatgg atttttattt ctgtggactt tggactggct gtctactctt ggtctcacat 369240
tctctactgc atatctcttt ggctaagaaa attagtattg aaaaatggtt tatggatcta 369300
gttattggag ctagtattca actttttagt tacttaaaag ataggactta aacagagctg 369360
aattttatag ggtcttttat tttcttcttt ggtccttaag agaagactgc agaaaactag 369420
acaagaggaa tttgaatgtt ctcataacaa agaactgata aaggtttgaa gtgaaaaata 369480
tgctaattac cgtgaattga tcattacaca atatatacat gtattgaaac atcatactct 369540
agcccataaa tataagaaat tatcagatgt caattaacaa tggaataaaa tgaaattaaa 369600
ttttaaaatg aaaacattct agaaaatatt cccaagaaga gatttattta tttatttttc 369660
tggctatcta tccttaaggg ttcgggaaaa aatggccggt ggagaacaaa agattgaaat 369720
tttagctcat tcatgatgca cgtgaccggg aaggagtgtt aagatgtcct gtacttcctt 369780
ccataatcac aggttgaggt gagggttgcc taaagtctga tcagccacat tttgacagtg 369840
gagactcaga ggcctagtta ggaacacaga aggaaaaatg ttaaaggcag acctttataa 369900
ccaaaacaat caacaggtct aaaagccaaa gaaaccagta tttcagaatt gttaacttac 369960
tcctagatgt gtgttaggca tcgggcttat cttaaagaag tgtcttagac cacagaaaca 370020
tagacccatg atatttggac caagcatagg ttaaaactag gggagggagg cacgaattac 370080
aaaaaaaaaa aaaaaaaggt gattccatgt tagaatccca tgttgaaaag gtattacact 370140
ttattgtaat acagacaaga tttcactgtg ttggccagac tggtcttgaa ctcctgacct 370200
cgtgatcctc ccaccttggc ctcccaaagt gctgggatta caggtgtgag ccactgcgtc 370260
tggcctaaaa agcatatttt aaaattagtc acatatggaa gctaagtagt gcattttgtg 370320
tttccgaaca ggacttaaaa cgtcagtgcc ataaacactg gtatgtattc agacacactg 370380
gtcatatgtc atgaatttgg tagacatatt tgtaggcaaa taatgtagag atagagtcac 370440
atattttaaa ctaaacaact cactatgaac catcatgatg gttcacacct acaattccaa 370500
cactttggaa ggccaaggta ggaagatcac ttgaggtcag gaattcaaga ccggcctggg 370560
caaaaaagca aaactcctct ctacaaaaaa atttaaaaat tagccgggta tggttgtaca 370620
tctctgtagt cttagctact caggaggctg atgtgggagg attgcttgag cccaggagtt 370680
tgaggctgca gtgagctatg gatgtaaccc agaaagaccc tgtctctaaa aaaaataaat 370740
atatacaata aaataaaaat aaattaaaaa tttaaaaagc cactgtgatt cttctctgtg 370800
atcattcgta agtcatacac tattttgtgt gggtgaaaca tgtgatctgt tagtgggtct 370860
gagaaaatca tatttattaa gcaaaaaagt caatatgtgc ttgtgttttg cttatgaatt 370920
tactcgaata aaatgtctga aggtcttgaa acttcttaaa agaaaatggt tcttacttca 370980
ttttggtgtg tttacattaa ggggagccat gtgacctctt atgagagtta ctgtcaaatt 371040
tcaagtgcat gggcattgcc tggaggactt gttcaaacac agattgctgg aaagcccaag 371100
aatttgcatt tgtaacaagt ttacaggtga tcatgatgcc gctttccctg ggtgactcac 371160
tttgagaacc actgtcttgt gagtttagag ataaagaatg gttgaggtcg tgtgcgatgg 371220
ctcatgcctc tagtcctagc actttgggag gccaaagcgg gtggatcacc tgaggtcagg 371280
agttcgagac cagcctgcct aacatgatga aaccctgtct ctactaaaaa tacaaaaatt 371340
agccaggtgt ggtggcgggc gcctgtaatc ccagctactc aggaggctga ggcaggagaa 371400
tcgcttgaac ctagaaggcg gaggttgcag ggagccaaga ttacaccgct tcactccaac 371460
ctgggctata gagcaaaact ccatctcaaa aaaaaaaaag aatgggttgg aaaaaatgtc 371520
tgcacatcag taagcacaaa ataaccattg ataaatagca ttacaagcat ccaggatcct 371580
aacaggaggg gagaaaatca ggccacttta gaaacacttt tatgactggc agttatccag 371640
tttgctacta aggtcaggtc taaaagattg ttaagactag cctgtttctg tatccatggg 371700
tatcagctgg ggaagccaag ttctgtcttt gtgcttggca gccctcccca atgccatgtc 371760
tctgctgatg acattggaat ttcctccaaa ttaaacagcc tgacagcagc catctgtaaa 371820
gaaggcagca aggttacgag tgatcactgg ctagtgccat ttctgctgcc aaccaggcag 371880
gcaaagcttc tggcatgttc ttgaccacct ctgagaagag ttgatgtttc ctttggggta 371940
tcatagagtt tctgccaccc agctctgttt ctctgcctcc tggtgcctgc ccctaattat 372000
tgcatagttg tcactgatcc tggtaacctg actgctggat ttttgctcca gaaacctaca 372060
gtaaaggaga ccgtaggcca ccagaagcca ggaggaaaca tcaggctgca gtcaagggca 372120
ctgccttctc ccctccaggc tgctgggctt tgagggcaga gaaataaaaa gactgaaagg 372180
gattagaggc ctggagtcca caacaaagcc ctgtagtcat ccaccacctt gcacagcctc 372240
ttcctgccat gcttacaggt gaaaagtcta gttcatagga cacattgctt ttccagaacc 372300
ttccgctgcc ttccagagcc agcattcttc ctgaaaactc tctcttgcca gttgtttgcc 372360
ttcagagtta cagtttaaaa accaacactt aaactgatat cctctgaaga aaaaaacaga 372420
taacaaattc atgaatcata gttatactta aatttcctcc gtcacagaga aacatgttat 372480
ttttagaaag tggatcccaa acctaactga tcagaatccc ttgggggaaa tgtttttaaa 372540
aaataccatt acctgtgcac tggcccagaa aatccagggc cattagagac tgcaaatgtc 372600
tgagaatctg tgtttcctaa aaggcacaat ggtgattctg atgggcagcc atgtttgaga 372660
acctctgatt gaattgtgca caattttgat ggtgctgctg ttgcattata ggtaattcaa 372720
agaagagctt ctttttttta aaaaaaaata gtaatctata aatataatag ttttcatctg 372780
aatagtgttt tcttgttttc agaagacctt cataactttt tttttttttt tttttttttg 372840
agatggagtc ttgctgtgtc acccaggctg gagtgcagtg acgcaatctc ggctcactgc 372900
aacctccgcc tcccaggttc atgtgattct cctgcctcag cctcctgatt agctgggatt 372960
acagacgtgt gctcctacgc ccagctaatt ttttatattt ttagtagaga tggggtttat 373020
ccatgttgtc caggctgatc tcaaactccc aacctcagat ggttcacctg cctcggcctc 373080
ccaaagtggt gggattacag gcgtgagcca ccacgcctgg ccataactat tatctttgac 373140
aattttcctg ggaggtggat gacaggacct gttactgacg ccagtttaca tctgagatgc 373200
tgcagtggag aggaattgga actagaaccg acacttacgg cttcttgtct ggtgtactct 373260
ctgctgttcc atcttcattg cttgtgtgca tgcgtgtgtg tgtgtgtgtg tgtgtgtgtg 373320
atgtgtttat ttgactcctt gaatctatgt tgtcttgttt ttcgtaaatg gattaacgcc 373380
actaccacgg atcatcaggg agatatgacg ctagagatag ataagccaaa tggaggtaga 373440
aaatccaaac tgaaaacagg gagagaagct aagatagacc caaggagtct aacaacccaa 373500
gttctaaact agagagaagg ccactgttca tctatttcag ggatgggcag ttatggaaat 373560
agtatgaact caggcatccc aaaggcagtg cagtgtatga gagaaagatg cttgcatgca 373620
tactcccagc aaagctctca gtggggccca agatgcaggg catggagggt aataaagatt 373680
agccaggaag gtgataggac aacagatact gaaaacatgg caatgaaaaa acatcagcat 373740
tcagaggtga gaattaccat tgccagaagt tcttgggaag taaaacaagt acagagctat 373800
gggtcaagga tctcacagtt agagtactag tagcagtagg gtggacttga gtctgtagtt 373860
tgggaccagc tgctaactta aagcctggga agctcgtgtt agccagacat tacagatact 373920
ttttatgtca ccttgaacaa gcttcactat ccttatattt aaaataagga gtaggcctat 373980
taataatctg tatgtatttc ttgcagtaag gaaatctaat tttgggaaat gaatagcaag 374040
aacatagctt ggtgcagtga gtcagtgaga ggatttacaa aaggtgaacg tacacaggac 374100
tcttaatact gatcctgggc tagtcatgtc attgcacatg acacctgctg ttggaaggaa 374160
caggttaagc atttagttgt gtgcaatgaa cctgtgagcc ctgtgggctg gtcccactta 374220
tttgaaatag aacgattgca gtgcctatgt gagtcagggt acacctgaat gtttagttag 374280
tgctttccat taaccctttt caattttgct tctatgtttt cttttcctcc agaaggaaaa 374340
tgagcagaag gtgtgtcaca tgctcgcttt ttatctgctg cgtagttctt gtagtgaaag 374400
gattgtcgat aagttcagaa accaagacta ctgctgcctc cccttcattc attcagtagt 374460
cttacagcct aaagaagaca agaaaattaa ggactctcaa ggcaaaagga agtcaaatga 374520
aattgggaag tgggtctaca gtaaatgcaa tatctgtcgc tttcttttag aactgcataa 374580
accacatgga aattttccgt gtatatttgc taccaaggga tgctatcatc tttttctttc 374640
cttttttttt tttctttttt tttggagatg gagtctcgct ctgtcactca ggctggagtg 374700
cagtggcgcc atctccactc actacaacct ccgcctcccg ggttcaagcg attctcctgc 374760
ctcagcctcc cgagtagctg agatgacagg cgcgtgccac cacgcccggc taatttttgt 374820
acttttagta cagacgaggt ttcaccatgt tggtcaggct ggtctctcga actcctcacc 374880
tcgtgatctg cccgccttgg cctcccaaag tgctgggatt acaggcgtga gccaccacgc 374940
cgggccacta tcatcttttt aatttaggca catagtgctc aggaaaagac aaggatgatg 375000
gatggtaatt aagtaaatga agacagcatt ggtcaggagg gcagtataaa caaagtaaaa 375060
tagaaagtct cttgttctat tttttttaaa taatgataat tatatatttc ttacagtcat 375120
atccagagct tacttgaatc taaagcagta tttatctttg cagcaagcct atgaattagc 375180
tttacagact gtaggatgca gagacccttg gattagaaaa gttcagtaac ccatgagcag 375240
aggcatgaga atgttaaaac aagtcactaa aggtcacata gcattccact agctgggctg 375300
tggttagcac tcatgacctc ctggggtctc atcttttctg aatcttattg aatcatgcca 375360
gctttctgat atggtccata aaatgctgat agaaatcaca tgtgaagttc ccaactgtga 375420
ggacagcaga cttcctttag aagataaata ctagacctaa tctaatacac tttatttgac 375480
gtagcagaat ttctcctgca tccttatttc aaaagcatac ctgcctgtgg tcttcccggg 375540
tcttaggaga gtccatatgt ctgatggaag cagacaatct agtgctactc agagaaacca 375600
ccacttgatc ctcagttttt ttgaggaatt tcatgtgttt ttatgtgaag aatcactctc 375660
aggaaagttc tgtattttgg tagcagagat cctgtcaaga aggcagtgag atagatacac 375720
ataataagct gttcatcatt actgctgatg gaactcttcc caggcctgca gctgacagca 375780
ttgcatggga cctgcagccc ctttcaccgt gactgcagat tctttggtta agagactgtc 375840
agtggtcaag gctctgcccc ggcttctcgg gatcttcaca ctcccctgtg catagtaggc 375900
tttgggttat tggccatcat gaaaaccaag attgtcgttt aatgatcaca tctatggact 375960
tggggtcgga ggaacctgga ttcacatctt ggctcctcca ctgactggta agttgcttag 376020
attagttgct tttttcctct ctggctgaat ttatgcaatt gggagtttta aaaagtatcc 376080
actaaattca ttgttgttgt tgttaagatt tagttgtgta ttgtacacta cctggcatgt 376140
agtggatgtt tggtcaatgg taactattaa aattattgca gatatcctca ggtattatat 376200
ttttgacagg agatatctga tagcctgatt cgatatttta tgtggaagga agaattaaat 376260
acagaagaac cctaagacaa tgctatctgt tctagagagt gtttcgttaa agttgcagtg 376320
tttcataacg aagcaggcag gacggccctc tgctatgcag agctctcccg ctcatgacaa 376380
cacaacaagc actcccggtt catccctacc tactcatccc aacaatgttt ccaagttgtt 376440
ttaaggattc agaatggccc cactcctttt cagatgtccc tgggagggta acccctgcct 376500
tgtttgagaa tcacgagcaa gcatagtctg agtttgactt ctgtacccaa gtagcagggc 376560
accacctccc tctcagtggc tgatggagag gtcttccaca gtgaactttc agtgaagaag 376620
ttcatgtctc tctacattat ctgttttact cagcattcag agatatgtgg tgcctccaca 376680
ggggccatat ccaggctttc tgatgaccct atagggagca atggcaattt aatgaggagg 376740
ggaaaagatc agcttaacct agcttctact tcatccgggt tctcatggtt agttgagagt 376800
gctgatccgt gaccaccatt gagtcattga tctcccgctc ttcctagtca atctgtcatt 376860
cagagatttg cttgatccct tgtgccagat gcatgtattt aacaagctaa catgcactaa 376920
gcatctgcta tgtgtcaggt actattagac gcatcatact acaatgacta agacacagtc 376980
cttgtcctca aagaaatagt agccctggga gtaaaaatga tataggggag gctgggcacg 377040
gtagttcacg cctgtaatcc tagcactttg ggaggctgag gcaggcagat tgcttgagcc 377100
caggagtttg agaccagcct gggcaacata gtgaaacccc gtctccttta aaaataatca 377160
aaatattttt aaaaagtgat ttgaaggagt aacatcctgt tcatgttcag aggcattcag 377220
cctatgagcc caaggagtta cgctcatttc tctctatgta catcttttag tcctaatatg 377280
cgtttcttca tttcttttat ttttgttacc attatactct ttacacaagg tccttcacca 377340
gagacctgtt atcagtgtca gagacccagc cctggtggcc ttgtgcagca gatcagaata 377400
actcaaggag ctcccacatt tgctctcctg actttctaga ggcacacgat atccacatat 377460
gttaatgtat tggttttatc ataggtttct ccttgcattt ctttcatgta aaagtgttaa 377520
gagttcagtc tgatctgaaa gcaaaagttt aagttctcag cataactatt cttacaatct 377580
tgtgcctttg caaatatgtt aaaatgttct cagccccctc cagtcctgaa ctccccattt 377640
ttttatggtt aacgcgctgt caccactacc cagcagacta caaagcagca gcaagtgcaa 377700
tgcagagaac gcgatgtaga tcttgttcaa agcagctgac atgttgtcat ctcaggaagg 377760
gcagaatggc aaggaggagt gattgatgga aacttgatgg agcaaccttc acttaattat 377820
ttttgcatag attcctgaat tgtggcttct ttgctggaaa aaataataat gatcctgtaa 377880
tgcagactgc tttagaggct ggaatgtgtc atcgtatgtg aggattacca cttgctcttt 377940
tagaacccca agcatctatc tctacctaga aattttttat cgtgaagact aatagcctta 378000
agggtgaagg agaggacaga gaccctaacc cagagtaaga taggaatgat taggaatgat 378060
tgttggtgat aatcagatga acacactgta gccctgtatc aggagagaaa atgtgtttga 378120
gattagcacg ttatcagaaa aatgtttgca cttatcttat tctttgaata agttgcaagc 378180
tatttctctt ctttcacaaa ggcaaagtag taagccaaac ctgtaatcag aaaaatattg 378240
atatgttaga tagagaaagt tatttttgtg tgtttgtttc agttgttgaa tcaactggta 378300
tgtatcgagt acctactgca tgtaggggga ttgtagagaa ctttcagcgt caagttagag 378360
attttaaact ttatcctaga agtaaaacga gaaattaagg cactgagtta gaaaggagct 378420
agaccatgat ttctcccata tctcttgtgc aaatggcact agccaagcca gaagccccta 378480
tgctgttcct ccatgtgccc ctgcccagcc attcagcagc cttggtgctg agtctgcctg 378540
ggacatctcc cctgtccgcc tcctcttctc catgcttact gcccctgcag caggccaaac 378600
ctgatgacag ctcagtggca ttgcagcaag ttcctcccga ctgtttgcct tgcctgtaga 378660
acctggtccc ttctcatcca tcttctactc tatgaccaga gtgacatttt taatcaaaaa 378720
atgttcctgc ctaacccttc tgagattctc cataccttca agagatatct tggggagaga 378780
agggcactcg ttacctcctt cctcccctcc tggcatgcca tacttgtgct tccctgaatg 378840
tggcatgtcc ccttatgtga ctctgcatga gctccctcct ctgtctagac aatgttccct 378900
ctcacatcac atgcagtcac acattcctgt gtactcttca aaactcaacc ctgccatcag 378960
ctccaaggag cccaccctaa cttttccctc ctggtctcac tgagccactc tgtgcttccc 379020
acccatgaaa ctcatatgta agatttttag tgtctgttct cttgaccatc tctgcacact 379080
ggatacagat gtattagtct cttctcacat tgctatgaga actacctgag actggataat 379140
gtgtaaagaa aagaggttta attggctcat gtttccacag gctgtacagg aaacatggct 379200
ggggaggcct caggaaactt acaatcatgg cagaaggaga aggggaagcc agcacgtcct 379260
acgtggctgg agcaggagga agggaaaggg gaggtgctac acacttttaa acaaccagat 379320
ctcatgagaa ctcactatca tgagaacaga gagggagaaa tctaagcccg tgatccagtc 379380
atctcccacc aggcccttcc tccaaacact ggggattaca atttgacatg agatttgggt 379440
ggggacacaa atgccaacca tatcaatgga gctccttgag aacaggaact gtgtctttta 379500
gatcttctgt tttatatgtc tgatgcatag taggcagttg gtgatcactc atttggtgaa 379560
tgaagtgtta ggctgaactg aagtgggaat gaatatgaag agataccaca cacctgcatt 379620
ccttgctatc tgtgccattt gttccatctc atatctcatg gtcacaccag tctgagcaag 379680
gtcagatact ctttttagag aaccttctgt ggccttattc catgttcagt tgtttaatca 379740
cgattacctt tatttttgta ttggtccatg tcctgagtat tttttaaagc attgactgtt 379800
gtggatccat ggagaagtca gagaaaacag atgaagctct ctgataggaa aaaggattga 379860
ataatcttgc catccaaact gtggtatcaa aatatgacta tatatgttgc aatcaggtgc 379920
atgcgtttct tggctttcct ggatgtgcaa aatagaattc aagacagggt acagagagaa 379980
cacattctac ataccccaca taaccttggc atgactgttt ggaccttgct ggtaagaagt 380040
ggcattggct agtcttttgt tcacaggctg gcaaggttgc tcctgatttt ctctttacac 380100
ggataattcc tttactgacc aaatctcatg agagcaaagt gaagtatcct gtagctggca 380160
ctacattcat gaccttttct atgacaggtt aatcatttct ttgtgtgttc actcactgac 380220
ctttacttca ttggccaaag gagtgcccca tgtcaaagta atgtcctcgt tcctccattc 380280
catcatccct ttggggcaga aaagatgctg tcttacccgt ttttgtcccc agactagctg 380340
ggtgcctggt gtgtagatgt taaatgaata aattgtttag gcaaagccgt tagtagcatg 380400
atctaatgac cacaaacaga aaagtgtgtg tggtggggaa gggcaactta tattttaaga 380460
attgtgtttt aataagtggt gaattatttc agtataaatc cagtattatc attaataata 380520
gataaatata ttgagcattt accataagca ccatattcta tcgcctctcc cattacgtga 380580
aagactaagt tttatagttt gaaaagaagg aaaataggaa atatataact acatttaata 380640
ttatagcata aagggctcaa gtggaatgat gctggtatga cagagtattc ccaacagtcc 380700
tcccagttct ttttacatta atataaaatg ttccatgaat taaagaaaaa tatagcaagt 380760
cataaacatt tacaattctc tttcctcacc atctaaggag gacaagttct gtgcttattt 380820
agcttgctat tccttgtgag gtcagaaagg tcaatgatta aacttagatt aggccaaatt 380880
cctccttaag agaagatatg gtgcggggta gggagtgggg aacataagaa cagccattat 380940
agggacctgt aagagaggag ggcgagatgg gaggaagagc aatcgtcctg ggaaaaggga 381000
acttgggaca gagaggagta acaaggcttt cagggagtct ttctgagcat ggtgccatgc 381060
tccctactcc ccacttccac cctccccact ccccccctcc cattcacctc tgccatccag 381120
gccttcccag gaacacttgg ccaagacttg caagtttatt tatttttttt ttagctcatc 381180
agctgtcatt agtgatagtg tcttttatgt gcagcccaag acaatttttc tccttccagt 381240
gtggcccagg gaagccaaaa gattggacac ccctgctcta gatgtgagtc ttggatgacc 381300
acccttcact ctacctaggc tacagtaaca gacgttgaaa gtcagcatct tcattgttat 381360
ggaggaatgg aaatgggata aactatttta aaacaatttt ggatttaaaa aaatagttta 381420
aatattcctg ttctctcacc ccacccaccc ctaacttctt tgcattatta attttcttag 381480
ctaatcttat ttctaaaaaa gcaaaacctt ccaagggaat tctttttctt ttctttaggg 381540
agagagtctc actcttgtca cccaggctgg agagcactgg cacgatcata gctcactgca 381600
tcctcaaact tctgggccca agtgatgctt ccacctcagc ctcccaagtt gctgggacta 381660
taagtgcaca ccaccgtacc tgggtatttt tttttttttt tgagatggaa tctcgctctg 381720
ttgcccaggc tggagtgcag tagtgtgatc ccagctcact gcaagctccg cctcccaggt 381780
tcacaccatt ctcctgcctg gctatttttt taagcttctt gtatagatgg ggtcttgcta 381840
tgttgcccag gctggtctta aactcctggc ctcaagggat cctcctgcct tggcctccca 381900
aagtgctgag attagagcca taagccacca ggcctggccc aaatgaatta ttaatttgtt 381960
ttgggtagaa ttactaatag ccaattacta gttagtggaa cttcaatttg ggatgttttt 382020
atctatttga ataaactttc attctgtata actccatgtc taaatctata aatgtagaca 382080
tacatcagta tagaaacgtc agtggctctt agattgggta ctttaataat aactctccat 382140
gactgaccac tggggacttc tcaaggagca ggagaagtat ctaccaaacg tagatacctg 382200
agaaatagtg gagtctgctg taatgttcac tgtggataac ctgactggca gagttgtccc 382260
ttctggaaga gaggcagctc aggtcactgt gtaaggcacc tgtcttaact tgcaatggga 382320
attttgcagt caggtgaggg gcacaatata tgtgaagagg aagtgaatgt tgttgatagc 382380
atcacatcat aattaaattc cagccactgg atgatgaagt cattccttca cacacaaacg 382440
gcattatatg cctgtaatat ttttccaggg ctgccattac aaagtgccag aaactgggtg 382500
acttaacaga cattgagtgt ctcacagctg gggggcctgg aagtcagaga tcaaggtgtg 382560
ggcagggcca tgctccctgt gaagatgctc gggaaggatc tgttccaggt cactccctag 382620
cttctggtgg ctccttagca tgtggctctg tcactccagt cctcacagag cactctgcct 382680
gtgtgcctga gtccacattt cccccttttt ttttcatgat ggagtcttgc tctgtcaccc 382740
aggctggggt gcagtggtgc gatctcactt actgcaacct ctgcctccca ggttcaagag 382800
attctcctcc ctcattctcc cgagtagctg gaattatagg cgcccgccac cacgccaggc 382860
taatttttgt aatagtagag acagggtttc accatgttgg ctagactggt ctcgaactcc 382920
tgacctcatg atccgcctgc ctcgacctcc caaagtgctg ggattacagg cgtgagccac 382980
cgcgcccagc ccacatttcc ccttttcaca aggacaccag ttctgtcaga ttaggaaccc 383040
ctctcctcca ggatgacctc atcttaacta attatatctg caacaaccct atttccaagt 383100
aagttcacat tcagaggtat taggggtcag gatgtcaata tataaatttg gagggacaga 383160
attcagccca taacaatgcc tgccagtggt agttttttgg gggtcagggt gagtctagta 383220
tctgcatttt caacagcatg cctttttggg gagatgagtg tcaagcattc actgatttga 383280
ggtaacgggg ccctcttgag tctgtgatgt aatctcacac tcccctaaga gctatttatg 383340
gcctacaagc ctgtgcacat ttgaatgcgc gtgtgcagaa aagacaatga gccagacagg 383400
cttctacacc cacttaagag cactcacatg gatcagtcac ccaccctgaa tgccacgtta 383460
gttttgacat ctgaaatgtg tctggcattt tcaggcagag aaggctttta aaaaaaaaaa 383520
aaagtcacat ggatgccagt tccttactat ctccctaaaa gagcctaaac acagaaatcc 383580
agacacagga actcacaaga atattagata ataaatagcc aagcttctga agaggcctgg 383640
aaccagagaa tgatatttaa gggttattaa gcttaatttt ttgcactgtg gtctgcctgg 383700
catatagtag acactcactg aaagtttgtg aacagatgac taggagagtc tctgttccgt 383760
gggtatgaat cttaaagatg catgtattca gccccttctc ctggcttctg ttctaagcag 383820
agggaatctg atgccttgtt tctgcgcatc tgtgatctgg gcagattaca gatgtcacaa 383880
gccagtgatg tacacctgga ttgcatcctg accaaaatca gggaagtacc cgctggcatg 383940
ttgaggacct cctttgaaga aaatcctgtg gctaaaccaa ttcattgccc ttgggagaga 384000
aacattctat agcctgctgg gtggatgtgt acagtccatg tggacccacc taagtttcct 384060
attttgttcc ttctttcttg ttttcctttc cttcctcttt tcttactttt taagccactt 384120
attgagttta tcctttcaaa actcatcttg aggatatgtt caaaaatgac ccatctagag 384180
cttcctgtac acttctttgc agagtgagtt gctgctgact tatttctcct tccagcgtct 384240
tgctgatgcc tctgtagagt catttattac ctgcgtaaga gtgacctcta cacgtgcctg 384300
gttcccaaca agacatggag tctcaactga attttactca tctctgtttc cctaatacct 384360
agtgcagtac ctggttagca cttcctggat gttcagtgta tggttattga atgaatgaat 384420
gaataagctg ttactttctg cttgcatagc actgttctag agtgtcatgg aggacacaaa 384480
ggaatagaat tgatagtagg tcattcttca gttgcgttgc atcacaaggg taaaacgtgt 384540
acttattcaa aataagtggc ataataataa cttcttaaaa tttttatttt atttttccgt 384600
aagttattgg gatacaggtg gtatttggtt acataagttc tttagtggcg atttgtgaga 384660
ttttggtgca cccatcacct gagcagtata cactgcacca tatttgcagt cttttatccc 384720
tctccccact cccactcttc cccctaagtg cccaaagtcc gctgtatcat tcttatgcct 384780
ttgcatcctc atagcttagc tctcacatat cagtgagaac atatgatgtt tggttttcca 384840
ttcttgagtt acttcactta gaataatagt ctccaatctc atccaggtca ctgcaaatgc 384900
tgttaattca ttccttttta tggctgagta gtattccatc atatatatgt accacagttc 384960
ctttatccac tcaattgatg ggcatttggg ttggttccat gattttgcaa ttgtgaattg 385020
tgctgctata aacatgcgtg tgcaagtatc tttttcgaat aatgacttat tttcctctgg 385080
gtagataccc agtagtgggc ttgctgaatc ggcatcataa taacttaata agtcaagagg 385140
aggtctgggc actgtgctca tgcctatact cccagcattt tgggaagctg aggtgggagg 385200
actgcttgaa cccaggagtt tgagaccagc ctgggaaata tagtgagact ttgtctttac 385260
aaaaaagtta aaaaattagc caggggtggt ggtgtgcacc tgtagtccca gctactcagg 385320
aggctgaggt gggaggatat ttcagccagg gcagtcaagg ctgcggtgag ccgtgattgc 385380
accactgcac tccagcctcg gtgacagagt gagaccctgt ctctaaataa ataaataaat 385440
aaataaataa ataaataaat aaagtcaaga gaggggccca gtggtgtaat ggaagagcac 385500
tgttcataga atctgtagat ttgttttcta gtcctggctc cacaagttac atattctgtg 385560
ctcctgggaa cttcccttaa cctacatgag cctgagttta ctgatctaaa aagtgggcct 385620
aacgcctatc tgaaagaatt actggggata ttaagggtat aatgtatatt ataaagtgct 385680
tggtaagtca tagcatggta tctaaatcta aggtatgttg cttttatgac acaaggcagt 385740
atctgagtta ggacagacca ggggagtggt acaatcagtt aatgttctga gttgctgggt 385800
aggagttagc aagtaaggca cgtgcaagaa ttagaacttg gccagagctt tgaagaataa 385860
ggccacctgg catagacaaa gggaagcagt gtggcctgag tacctgcaca caggttgtgg 385920
tgggccagga ggatatgaac gagccccatg gctgccatag agggctggtg gtgcccgaga 385980
tggccctcct tgccatgaag taggcagaag gcgcttagag ctctagtttc ccaaatggag 386040
ctcaattgct tgtcatatta catacacgtg ctgttatgtg tgatgatgct ctgttctaac 386100
cctgaaagac ctggtggagc cttagcaaat cactggccat tctcccaaac actgcgtgtg 386160
cttatgctat gccgccatag ttttacaagc atttttcagc gtttatgcaa atgctgccct 386220
tctgtctttg gtaactgctt tgctcatctt tcaggattca gcttacatct tgtcttctct 386280
gtgccacatt cctgtcagca gccacctcac accacccgct cctgtgcaca caggcgtaca 386340
gagatagtct tgttcctctc tgctcttaga gcaccattca gctaccccca gtggagcact 386400
aatcccagtg agctgtgatg gtttcttggt gtctgtctcc ccgcgagacc atgggctctt 386460
ggtgaacagc ggctgtagcc tgttcagctc tgaccctccg gaccctcata taacctgtat 386520
gacccatgaa ggtgcacagc aatgggaagg atgagggaag aagaaggatc ttttcaaact 386580
ctgtacattc ttcacacaga aaagcaggct catatcagct gacttgttct cccaggcaga 386640
gaacaagagt gtgccacatt cactccagtt gaatggtttc aaacttttct tcctttgagg 386700
tggatgtatt tttggctttt ggcagtgtct tagtccattt ggactgctaa gcaaaatacc 386760
gtaaacttat aaacaacaga aatacatttc tcacagtgct ggtggctggg aagtccaaga 386820
tcaaggtgcc agcagcttca ggatttggtg aggtttgatt tttttggttc atagatgaca 386880
ccttcttggt gtgtcctcac atggtggaag gagcaaggtc gctctctggg gtcccttata 386940
gatgggcact aatcccatat atgagggata ctgaaagtaa attgatggaa gtgctcgtgt 387000
gaatgaatga atgaatgaaa ccattttgaa gctagattgc taggttcctg caggttatat 387060
ctttgtatac tccttacctt tcaagaatgt ctgcagctct ctgcatacaa taacttcctt 387120
gagtatatat aactacagta tgacaaggct tttaaattga acaattctaa agactgtttt 387180
tttgagtcca aaaagtagaa tttggtatca acattaggtt taaaagaagt gatttcagag 387240
tttgtcaact attcaagtgt cagaaaaaaa taatgtaaat gatgtgctta agacatttat 387300
ttttgtattc tcgattctcc tgaaataaag ggaaattgtc ttgaaaagct gtagatttta 387360
aatgaaaagg aaagcgggaa ggtgacataa tttgcctctg cctttgcaga aattcaagtg 387420
tatatggcct ctctccaatc caccattttc ccacctccac aggccccatg tcagctgttt 387480
ccttcatatc attgcaatgc tttgagggtg attgttggtt taagctacag tcccttcaaa 387540
tttgtgaaag actaaacaga ttgataacaa ctccacctag attaaatgaa attctgtggg 387600
tagacaggct agtcaaaata caatccccac acaccccaag tgagcattgc ttctcctttc 387660
agatatgctg tgggtacaaa gaaaggattt agtccaaagt gccttggggt tttgttcagt 387720
ccagagtgta atttttttct ctcttttgcc tatagccatt tctgtaacat tactgaaagg 387780
gcttttttcc taatgaagca tgaaaattga tcgtatcttg ccaggagagt tcttcctaag 387840
tcttaagata ttaaagattt catgagaacc gcatgaagaa tatcttcttg aatcatttac 387900
atttttccct tttgtaggct tatgtaacca tgcagaaaat ctaataataa gtgtgctatt 387960
agtgtaccat gtgccatccc gcaggcagct gtgccatggg gcaccagtgc ccagggcttg 388020
tggatagcat taacctgtac aactttctaa agtaaagccc agtgggaaat ctgtaggtaa 388080
ttgaacagat agtccatttt tatcagactt ccccctgccc cttccctgtt ctgtcttttc 388140
tcttttcttg tgccagaagg aaacaccttg gccataggcc tttcattcac aatggagtat 388200
attttccaaa gcaaatagct tggactattt caattcccag agcaatctag gtgggcacac 388260
agagctaaat ttgggtttga aagaactctt aaattagtat cataggaagg caatgagcag 388320
gaaaaaaaaa aataaagata caagcattgt ggtctgatgg aaattatcca gcactcactt 388380
acaaatgaca agtgggtacc acccagcctt tctcatgttc caaaatttaa taaagggttc 388440
catctaggtc ccccagaaac tactgtgatt atcagggtga gagaaggggg aatgatgaat 388500
ttttgtaatg ccccaatctt tgtaaccagg catagaagga cattcgctgg gctcaggatg 388560
ggtgttagca tgtagtggat aaaggaattg cagagttgtt gacagctgtt tcctcagaga 388620
cacttgtcct gatgatattt gctttggatt ctaagtaaca gagctgtagt tcttaaagtt 388680
taaattgaaa aaaaggagtt ttctgtcaag tggcttagtc atggaaatca gtgaagttaa 388740
gcttgggcaa taatatatcc ttttcaaatc caggtgcctt cctgatcatg ccagagcttt 388800
tgtgactcct ttctccttgg tgttcttctt ttgatgcggc gatagggtct gaacacgtcc 388860
aggctgtctt tgctgggaga gggcagaatg cctcggcttt cttcagcctt gcctttcttc 388920
attgtcttca ccctgcagca cttctgcaaa gctgctgggg taggtgggtg agtgggcgtc 388980
ttttctttgc tagcccaagc tgagttctga agggaagtta gcagggctca gctgctgccg 389040
caaagtcagt cagaccaatt ctcatttgca tgcctacaga attagacata ttcaggggct 389100
cgggttaatg ccataccctc ctcttgtcct tggaaaactg taagaatgcg tgcaggtaac 389160
tctgcagcaa ttctgtgttg ctcagatgta tttctcttct ttcagaattc ctccttctat 389220
agcattcccc taatatttat gtgctggggc tttcttcttt catcccaggc cccagcttcg 389280
ctctatatca gacagaggtg ggagctgctg atcaaggggg cacacttgcc atccaaacct 389340
cacgatgctc acaggtgtcc tttcaaccct gctaacccag atgatacatc accatttata 389400
cctttggagg cattttctct ttaattgatg ctcacttaga cctaagattg ttcattaaag 389460
tccagaggtg ctcattaaaa tgaacattgg atagtgtggt agatgcaggt tatcattatg 389520
aatccaagaa agggctctgt ggaacttgtt atatacggca tttataggtt gttaaattaa 389580
aggattagtg ttgtgctaaa ccattttcag gttaatcagt tgtgggaaac cagatctaat 389640
gttaaagcag gcttaaacta tggtttttat agtagggaag tttttaagct actgttattt 389700
ctaataaacc ctctagcttg ctaatcgagc atacttttca atttttgcac ttaactgaat 389760
atggtcttgt tccctaattt ttttatgtgt gggctttatt tcttcaagct ggattgtaag 389820
ttccttttta gcagggtcta tgtctttttt tttttttttt ttgctcatat cctaaaagct 389880
tctggtataa ttcgaggtat atagcagatg ctaaggattt tattgagtga ttactacatt 389940
tttagagtgt cattacaatg tattatcacc tggtttatgc cgtggtgctt tatgtaacat 390000
gtgcctattt acagaacatt gatataacat gttggtctgc aaccaggttg ttatcagcaa 390060
taggaaaagc attacagagt tcatatggaa gtagaggaga aacaggtcta atttgggtgt 390120
gatgccctgt attagtctgt tttcatgctg ctaataaaga catacccaag cctaggtaat 390180
ttataaagaa aaagaggttt aatggactca cagttccacg tggctgggga ggcttcacaa 390240
tcatggtgga aggcaaaagg catgtcttac atggcagcag gcaagagaaa atgagaggca 390300
atcaaaaggg gaaacctctt ataaaacaat cagatctcgt gagacttatt cactaccacg 390360
agaacagtat gggggaaact gcccccatta ttcagttgtc tcccagcagg tccctcctac 390420
aatatgtggg aattgtggga gctacgattc aggatgacac ttgggtgggg acacagccaa 390480
actatatcat gccctaacct gatcagatat ggcttccaga ctggcccctg gagtggcctg 390540
aataccttca ccaagacacg tgtgtgggac agatcaaaag tttccatctg ccatttgtct 390600
ttcacttggt aactgctaat gattgcttgt taaccataca cattaatatg cccgtgaagc 390660
agatagaaaa taaaataagt aaaaaattgt ataagtggaa aaactaagac ccaaacaaga 390720
aattatggat catttctaaa tggtggccag gacgtttata cggagaaacc ataccattga 390780
accataatca atgtaagaat acaactgatg gtttcagact ttcaggaata gaatgagtct 390840
caggcagaca tgttctcagg caacatggcc tgggacatcc ccagaaacct cctccatgga 390900
gttaacagga cacctacatg gccctatgtg tccctccact tgggcctctt gttcaacctc 390960
gtatcacatg tccccttcct accacataaa cttctgtctc tacattctct actctaccac 391020
aggttcattt atttgtttgt ttgtttgttt gtttgtttgt ttgtttattt atttatttat 391080
ttattttgat acagtgtctc actttgctgt ccagctggag tgcagtgtgc aatcacagct 391140
ccctatagcc tctgtctccc aggctcaagt gatcctcctg cctcagcctc cctagtagca 391200
aggactatag acatgtgcca ccacgcccag ctaattttta cctttttttt gtagagatga 391260
gttctcactg ggttgcccag gctggtctca aactcctggg ctcaagtgat ccttctgcct 391320
cagactccca aagagcttgg attacagaca tgagccactg tgcccagccc acagtcatgt 391380
tttaaagtgt ctgagctata aatactacta taaaggtgtc aactggttgt atatgtgggc 391440
ccttggcatt tcagaaatga cagttattgc caaccattac caaatggaat ccattttatc 391500
caaatgggca tggttggggc tgagcatggg atggagtaat gcagtcttat tgcatttcag 391560
tgttagaggg ctttcactcg gtttgcagtt tctccacagc tcacccacca attctacctg 391620
tgtacttctt ttctgttccc tctcaacttc ttttccattc tctccttcct cttgtttctg 391680
tccatatctc tggcttcttt taatttccct tttcccttct ttcttattgg tctggccctg 391740
ggtctggtga gaccaagggc acagaaggat actggctcca tgccaacctt tcctccaagg 391800
cacaatctcc ttcttggcat ttactgagat gttcaacttc ctgtgtttct aatattcctt 391860
cctgttttat aaaagaaaaa tagattggat ttgcaaagtg ccttaatttg ttgattttct 391920
aaaaagcaat tttaaaaatg tgtatcaaca atatcacata catgtaactg atttattgac 391980
tctggcttgc cctgggttta atcacacata aagaaatttt acaataacac atgatccagt 392040
agagaaagaa gtcaaagaaa tatgtaaagt cctgtgacct ctgtagacat ttgggattaa 392100
accaaattaa aacacctgta tgggctgggc atggtggctc atgcctgtaa ttccagcact 392160
ttgggaggct aaggcaggag gatcacttga gcccaggatt ttgagaccag cctaggtacc 392220
atagcaagac ccaatctcta ctgaaaaaaa taaaaataaa aataaaaata aaaataaaaa 392280
taaataacca ggcatagtgg catgcctgta gtcccagcta ctcaggaagc tgagatggga 392340
ggatcacttg agccagcagt ttgagactgc agtgagctat gattgcacca ctgcactcta 392400
gatgcaacag agcaagaccc tgtctcggct caaaaaaaag aaaacacttg tatcaattca 392460
ggtcaaatat tggtttcttt tttttaagag cagattaaca tcttgcatat cttttgctat 392520
cacatttctt cttatctgac cagctgaaat ggaactagtg ttaaatacaa ataataaaac 392580
ctgtaaagat cctaagtttt tgcatggtac aataaatcct cactcattca catgcttgga 392640
gaaagtccag tctgattcaa ttaatgaaaa gcaaaaaaaa aaaaaaattg taactacata 392700
atttttatct catgtattag ctcctattta gttcacataa gtgttcaaat aggtactcat 392760
ttttaattaa caaaatattt gtgtgtagtg agtattttta aaccaattaa aacagttcct 392820
tcttgtaagt aaattaagtg ctattcttag acgatggtat gcatcattca tttgctttgc 392880
aaaccattct ttcacaccat tctagttggt gtgaaagcaa attgagccca tctctactgg 392940
aatttattgc attctcttaa tttctgacac tctatgctcc caatagtagg gactccatct 393000
tagccaccac gacatcccag gcatggctcc tagaataatt tcagctcttt aagactcaat 393060
taatatttgc tcactgatta atatttagct ccattaattt atgtgtccaa attccttacc 393120
atttgccaag tgcttttgga ttttacagtt agttacaaac tgtagtttaa ggtttttctg 393180
gctttacttc attcttcctt taactagctt taaaaaacta gtttataatt ctagttacaa 393240
tacaatgtta agtgaaagaa ctgattcaaa attatatatt cagaattatt ctaactttgt 393300
aaacatgcat agatatatgt gagctttaaa aaagaaaatt atatatatat gccaaaatac 393360
aatcaaaatg taaatagtgg atatatcatg ttggagatat taggagcagt tttatatttt 393420
ttaagttttc tgtgtttcca catatgatca cactttattt ttatatcaga aaaaagctat 393480
cttagttgtg cattgtacat tagaaatatt agttttgaag ataacctaaa cacaagtttt 393540
tatttcttct gtcacagttg cctcttttct taaaatcgtg tttgccagtt tctttcacga 393600
cactgcaaac aattttagta gcttcagttc tttgataaat ctgtagcttt tagatctttg 393660
attactatta gcaaagaaaa gatagaccca aatgaaaaac agttgcattt ttgaaatatg 393720
tccggcgggg gttgatgtgg aaagaacaat tcctctcaac tccagggtca aagcagcagc 393780
cctgccaggc tctgtcgggg tcgcctggag aacatcactt aactttctac atcagttcct 393840
gcttctggac attataacat tcatgatatc cacctcatgc aggattcctg ggaggagcag 393900
atcagatcat aatgtgtgtg aaggggcttt gaacgacagt caccacatta ttaccaccat 393960
aagcattatt tccatttcaa aaatggtaga ggagggaaga tgcagatgtt ctctttatgt 394020
tggctcggca ccaggcacgt ccaggttgtg ctgctttacc ctccagcatg aagagttaga 394080
aggtaaatat cgatattgct tttcataact aatagcttca tagttcatgt caggtgattt 394140
cttggcttcc gttagcattt cagagaccat tatacacagc agccatcctc tgcagagctg 394200
gagaaaactc atttttcaag gcaaatagtc ccaagtcagg gttcagtcct ggtggaatga 394260
aataaagaag gagagtttat ctttaaggta agctagcatt taagtagatg ttggatatta 394320
tcagagatgc ttatgagggg cagagagcat tgaagactta taccctttgc acatctttaa 394380
atgcctgtaa gtgcttacca ggagccaaga gcgaacgggt ggctgcgtgc aaatgctaga 394440
ggttaacccc tgtccatggg catttaccgc atgagtaaaa atttattgca gagttcagga 394500
ctgtgattct gctgctcatt tctgtagcgt atttctttat ctgaaaggat gcccattgtc 394560
ctttctagct ttttgggcca taaccgtgag ggaaggccca aaggaagaac ctctgttgga 394620
gatcaggttt attcatccat gtgggtggag gtacgaagga gggaagaacc tctgttggat 394680
atcgggtttc tttgtctgtg tgggttggag actagtagaa taggggaaac cacatactgc 394740
ccattcctcc aggatcattt tccatttgga tatttagaaa gcaacaagag aggagtttta 394800
gaagacaagg tagatgattt caagttactt taacatagag gaagaaagtt tccttctatt 394860
tttaatggct agtgcatgat ttgtgggagt gaagattggg agggggcacg gacgaacacc 394920
aggaagaggc ggttaattta ttggtcccca ttaattgaat ttaataagtg agttttgtca 394980
gtttagcaat atccattagt ttcagagagt gtttcagtat tattctgtaa aagcatccag 395040
ggatatattt tacagctaca gcatagatta tcttgcacac atattgaagt aaagatacct 395100
ttcaacattc cagatactga cttttcaccc aaatttgaaa atctccattt agcactttct 395160
aaaataccag tgaaaattaa tatagttttg tagatttatg tactaagatg cagattaaga 395220
catgtggaat ctaatgaaca tagcaggaaa agaaaatttt ctcaagtctg ttcattacta 395280
ttcctcatca cattttttat tatttaatag cttattcctt gaatatgtgt gacttgggat 395340
tagatgtgcc agttggaaga cctcagaggt tcagaaattc acagacatgt gaaatataaa 395400
accgtattca tttagcagat actgataggc atataaaata gaaccttcat catctatctt 395460
tagaaaaaga agattaaaca gaagtgtaat taatttgcca actctgcttc ccgattgaga 395520
catttatcaa agttgatctt taatcattag tttcctaatc tgtaaaatga agtctattat 395580
gacctctaag gtctatttgt aacagttagg attaggttca gttccatatc accaaaaaaa 395640
aaaaaaaaaa aaaaaaagaa gaagaagtca agccaaagaa atagacattt atttttctct 395700
cacataaaag tggttttgag aggtaagcag tccagggtga ttatggtcac tgcacaggct 395760
cagaaacatt gtcacctttc tattctgcca tgctgtagta tatttctttt cttttctttc 395820
tttttttttt tgagacagat tcttgctctg tctcccaggc tggagtgcag tggcatgatt 395880
tcagctcact gcaacctctt cctcttgggt tcgagcaatt gtcctgcctc aggctcccga 395940
gtaactggga ctacaggtgc gcaccaacat gtctggctaa tttttatgta ttttttagta 396000
gagacagggt ttcacatgtt ggccaagctg gtctcgaact cctgacctca agtgatgcac 396060
ccgcctcagc ctatgtctca catacaagat ggctgcatag ctctagcctt taacattacc 396120
attccagaaa gcagaaagga ggaagagacg aaggacctac cccctttcca aagacacttg 396180
ccagaggaac cataccacat ttttgtttac ttcatgtcaa caagaattta gtctaggcat 396240
acctagctgc aaggctaggc ataccttctt gcaagtctag gcataccttc ttgcaaggca 396300
agaagaagat caggtcattc agttgggcag caatgtgtct acctcaaaac caaggtttct 396360
acttctaagg aaaagaagga aagtgggata ttggggtaag caacaattat ccacaggttt 396420
tgagctcaaa aagccgtgat cgcatgtttc tgggaaaatt tgacctatac aatcgagtct 396480
gaatgtgtgc tgggtgtgta caaatcagac aacttcaact gtgagccttc attagctctc 396540
ccctttatct agacttagga ttgtatttcc aggcataggt cagaatcttt acactgattg 396600
tgtgtgtgtc tgtatgtgtg tgtgtgtgtg tgtgtgtgag agagagagag agagagagag 396660
agagagaaac agaatcttgg ctgcaagatg tgctgaatat aaacacaata acttagcaat 396720
ttataactgc ccctttccca tctctgcccc ctccccagta tcagcatacg cagtgttacc 396780
cccacactat caatatgtca atgattaata gcaactggca aatgtgtgct ttccatgaga 396840
cttgtatgca aggttactcg ggttcacaga ggctgctaat aacagcagca ctattgaatt 396900
atgctatgtg tctgtgtctg ttaagacagg tcggaggaca ggggaggaaa cttcccccag 396960
ggtaattgag agacaaagtc actaaaagct acagatctcc agtttgggct ctatgcatga 397020
gattgttctt aaaagtcaaa gaaatataaa aggaaattgc acatttgtaa tttttttaag 397080
ttccccattt catagctcat taaaaccagg actttaatat tctgggtcag aacccccatt 397140
ggatattttt gtgaacatgt aacatgtggg ttgattagag gtttgggcct gtttttttct 397200
ttttcttttt tttttttttt cagacagagt ctcactctgt cacccaggct ggagtgtagt 397260
ggtgtagtct cggctcactg caacctccac ctcccgggtt caagtgattc tcctgtctca 397320
gcctcccgag tagctgggat tacaggtgcc cgccatcatg cccggctaat ttttgtattt 397380
ttaatagaga aggggtttca atatgttggc tagtctggtc tccaacacct gacctcaagt 397440
gatccacctg cctcggcctc ccaaagtgct gggattacag gcatgagcca ccgtgcccag 397500
cctggcctat tttatttcat gcatatatag tttaagtgtc tctgagattc ttgatcaact 397560
aacaaaatcc aagaggccct tttgttatat tctaaattca ttcctgcttc tgattgttgc 397620
aaaggggtca gcggataggg tgccagagcc agaagttagc taggtggcag gttctgaatt 397680
aatgtggtat tctgggtaat ataatgtcat ttcctaggga actgccagca tctagctgac 397740
ctccaagagg acaagtggtc aggaaggtgg agatagtatt agaactgtta ttattgttgt 397800
tgtttttaac aagcagacct gtcatgaaac ttgccataga ggtccccttt tccatatatc 397860
accaaagcct cataggtaag aaaaggtaaa catccaagat tgtttcttta aagattgctg 397920
ttgggcagac caagatttag ccacaaaaat aaacataatc tctgatgctg agaagagatc 397980
agaatgagtt gaaacacagg ggaaaaaaga agtaagcaga aaaaaatttt acaatagtag 398040
atatggggat tagatagata gacggctata tagatatata ggactctgaa tagacccatt 398100
acaggcaggc atgtaagtgg aaatgattaa tatatagatg tagacacagg taattctata 398160
taaatgtgga agagcagcag gaagtttcta cagctgggaa ggaaaaggta attttttaaa 398220
aatgaggtca ttacaggttg tttgggtcca ggcagattcc cattgtcctc cctaaacact 398280
gcttgtaaac agttttggga ctgaatgcac cctttgactg tagtctatgc tttacattga 398340
ctagaactga caaacagatg aaaagtaaaa taatgtttct agagattttc tatttggtta 398400
tgtcattttt ttccatggac acatctggct aaagccaagg ggtgttaagc ccccaaatgt 398460
catttgaatg ttcttacagt atgaagaaga ggaagaagaa acactttgaa aaccaataat 398520
tcggccaggc gcagtggctc aatgcctgta atcccagcac tttgggaggc caatgtgggt 398580
ggatcacctg aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccccatctct 398640
actaaaaata caaaaagtta ggcaggcgtg gtgatgcgtg cctgcagtcc cagctactca 398700
ggaggctgag gcagaagaat cacttgaact tgggaggcag aggttgcagt aagccaaggt 398760
tgcaccactg cactccagcc tgggcaacag agtgagactt tgtctcaata agaaaaaaaa 398820
gaaaaccggt aattctgttt tggaactcct tgctctgcta tggcacatgt atacatatgt 398880
aacaaacgtg cacattgtgc atatgtaccc tagaacttaa agtgtaataa aatatatata 398940
tatatgaaaa aagaaaaaga aaacaacagt gctgattgag gtgtcacact tttgctggtt 399000
gtctctcctg ggtatacctc tagcttatca ccgccattct gggaagacag gagcaactgc 399060
cttttagctg tagtcaccac tcatttccct gttagcccct tgtggactgg aagctccttg 399120
aaggagacaa ggcaccaagt cacattttac ttcatatccc accaccatga tgtgcctggc 399180
acgtaaatgt tgaataatct gaacgagtgg atccctgaac agtttaataa aatggggttt 399240
aaggagactg tgacattcat gaatagcatc acatccaggc ttatttctat ggctttctat 399300
tgggctcaat gcctgggtcc ctggcacatg agaaacaagt atccttgagc agtaggggaa 399360
ccatacctta ttcttaccac ctcaaaatat ctagaactgg ctgggtgcgg tggctcatgc 399420
ctgtaatccc agcacattgg gaggctgagg cgggcagatc acgaggtcag gagatcgaga 399480
ccatcctggc taacacagtg aaaccctatc tctactaaaa atacaaaaaa ttagccaggc 399540
gtggtggcgg gtgcctgtag tcccagatac tcgggaggct gaggcaggag aatggtgtga 399600
acgtggaggc ggagcttgca gtgagctgag atcgcgccac tgcactccag cctggcgaca 399660
gaacgagcct ccatctccaa aaaaaaaaaa tctagaacct cagcatgaag ccatttttaa 399720
aatggtgccc tatacttagt caaattcagg caattcagtt tggggaatta ttttctgtaa 399780
atgaggtgct ctgaatcaga gttctgactc cagctttact ggctgcctaa gtgccatggt 399840
ttagtgtaat gaaaatacag tggggggtcc ttaaggcatc attcagggtc tacctttaag 399900
cgactccagc tcttgaactt aatgaactgg acactttcaa gttctgaaca tggtaaataa 399960
aagccagcac ctgctgccaa aataccttgt ctcataatca aaatcatttc tagagccagc 400020
ggaacatgga ttccctgaga aattcccact gactcagcaa ttttaggttg ggattttatt 400080
ttagagtcac ttaacgaaaa gatttcacct agtggcatgg ccccaatatt tatcaggtaa 400140
ctctggcccc atctcagcag actgactgat tcaatcatct taccctttac tggggatgaa 400200
acgaaatgct tactaactca ctcctgaccc cacctgccac tccaagtcat tccagcaaac 400260
aaatccgtaa tagattgctg agagggggaa gataggtgaa attggagaat acactaaaaa 400320
tcaactagtt ttaaacggta cgggtgggag ccatgccccc tctgtactgg tccactttat 400380
aaatcccaga gggaactcat tctatgcttg aaggaaaact ttgccttgtt ctttggttag 400440
attgtgctga acagatcaat tcatgtcaaa gagcatcaac ttttcttatt tatgccatgg 400500
cttccatacc acatcacact ttatttactc ttagtggaac cttgaatcaa tgatcaattt 400560
tgttttgtcc ttcagtggag tatcagacac caggacaacc tggtcagcaa atattctgaa 400620
gtcctcagca gttattacta gacaggatat tagcatatgg cacatcatgg aattaattta 400680
tgtaacacat acttagcatg cacctatcaa atatgtatca ggcacagtgc cacggcctta 400740
ggatggagaa gaaaaaacat agttcttgct ctcagagagc ttagatctag aagttgatag 400800
atgctgtttt ccaagtttct ccacttgtat ttctgaaact gtgaacagcc aactgacatg 400860
tagtaagcaa tcatttttcc agaaaaagtc tgttggggtg aaataacatg ataagggatc 400920
tgagaaaagt aggcagggta gggatggcaa tggggaagat tccgttataa aggaacagca 400980
tacatataga ttatatcgct gtatatttgt gtctgtgaag cacctcattt aattagatgg 401040
tatcatggca actagaagag tgcttactta aatgagcggc tccatgcaaa gccctagcag 401100
actgaaagtg ctttgtaggt attagctgtt attattccta ctgctcatca ctaatatgta 401160
gtaggcactc cataaaggtt tgcgacatga gtgggtggga gatttagtgc tgaaatgtaa 401220
acctatacat aaactgaata tcacatctat atgaatagag aaccttttac agtacaagca 401280
agagcaagat gttcacatta tattctgcaa agaatgatct gaacacttaa acttacaggc 401340
tccgaaagtg tctctctgcc caacatccct atccatttaa atagaaatgg cagtagcagc 401400
ttcctggtgc tgctggtggg aagagccgtg gtaaggtgtc tcctttcttt cactccggag 401460
cgggggtgat gacaggagag ggaccgggcg ggagcgaagt gatgatggtg ataatggggg 401520
taactgctga gagcgggagg gtgggggcca ggaacaggag gagtgtgagc gtgagaagac 401580
agtgctcaga agccgacacc caggtgactt ctctggaatc tccctgctct gaaatgggta 401640
acgtggctcc tttctctgaa gctccaacac ttaaaggagc ttcttgtttt aagcttcttg 401700
tgttaagctc cagattttta caagcatctc ttcagagcct ggtctccaaa gccatccgtc 401760
cagtcagatc aagagctact tgccctgttt ctccatagtc acgaactggt taatgtgagg 401820
ggaaggcaag aatggtctcc atcgtcacgg gtttctgcct tggtttgaag caagctccag 401880
cagttacatg aacaccagtt acggaatgtc tacagttatg acaagacaca gcagggctga 401940
cccggctcac ccagcaaggg aacaaaggcc atccacacgt cagacccagc aattcaggtg 402000
aaggaacaca cagaacctcc tagttcgctg gatgaggagt cccccaattt caccagataa 402060
tcacacaaca tgttttcata tggccacatg cccacagcct caagaaggtg aagcattttc 402120
agagaatgat tcctgacact acagaaacat tgaccattta gaatcagaag accctcagtc 402180
aaggctggcc tcacaggaaa atcaaatgta atgattccca taatgagttc aagccagaca 402240
actgaattat gcatctgaca ttaaaacaac tgggggattg taggaggagg agaagtttgg 402300
gaagagagag gacagtgtaa tcttctggga gtaaaattta ttactgaaca ttaaaaaaag 402360
atctgcaagt taagttgaga gtcattttgt ttatactcga aatgctacaa tgtcctttga 402420
tttgtttatg caagttttag gggacaagtt acgttttttt agcatataat ctacatttat 402480
tcccaaaaca ctgctcctga gacaatccat cagatatttc ctcaaggctg tggaaaaggg 402540
gataaaaggc atatttttaa aggtgggcgt gtatgtgcaa aacatgtttg ttttaaagag 402600
atctgaatgc tgtagaaata attagccatg tgcgtgaacg aaaataatga ataccaaatg 402660
gtacaatgtc ctgcttgaat cctgtttcag aaacagaatg tgaaggaaac attacgttct 402720
ctcatccctc tcttttctct ttcacccttg ttacccctga attttgtaat aatcactatt 402780
acccttttgg ctatgaattt aatgtctcta tatatagagc cacaccccta acacagattc 402840
ttcttgcctc tcagagacag ttaaatgtct ttgggtattg cactacttat tctccatagg 402900
ggctcagaca tattcactat tgagcatttt cattagctaa aataaattaa atgtatgtcg 402960
taaatgtgca gcaacactga agaagctgcg agctacatct tgtccttggg agtcatttac 403020
ttagaataag taaagacttt ctcacttgct agtttcaggc gtcttacctt gtgttattcc 403080
ttacaaatgg acagggctgt tctagaaccc acttcctgaa tacagggaaa gaccccagtg 403140
gtgtattggg ataatggaga cagacaggtc tgaatgtgag gtgtggacgt gggcttgtgt 403200
gtgtgttttc tccactggat ttcttcaaac ctaaagttgc tggatcacat ttctaacaac 403260
aatttgcctg accttatagg atctcctttc tcactgaata tgttacgatt agaggaacta 403320
agattggcta aaggactttt ggaatgagcc ctggacttaa aaacccgttg aagagggagc 403380
aaacaagagg aacagtgttt tccaagaggc ttacttctct taaattgaaa tatagtcatg 403440
ttccctggct ctgagggcac tttctcagag cccatatgtt tattcaagca tttgcttcgt 403500
gatgtgggag gctcagccag tgtaatccca ggcatgagat gttcaaatgc tgaatatgtt 403560
attcaagcac attatttccc attgacatat gtaaatttaa aaataaaata ataatgcaaa 403620
tttacatatt gaatcttggg aatggaaaac acatttccga tgtcactggg tatatctgtt 403680
cccctacttt aaaataggac tatagagctg ttctctttga agtcatctct gaccatacag 403740
tttaatccag tgggcattaa ttcagattct gggttagtgt cttgtagaag ctctccggtg 403800
cttctaatat tcagcagata ttgagaaccc atggtctaat ccaatggcca ttcttagtct 403860
ttctgtttct ctgctgcatt taatataatt gatgtcttaa ttttcttctg tcttttttat 403920
ttttattttt tacgtccata ggttttgggg gaacaggtgg tgtttggtta catgaataag 403980
ttcttcggtg gtgatttctg agattttcgg tgcagccatc acccgagcac tatacactgt 404040
acccattttg tagtcattta tccctcaccc ccctcccacc ctttctccca agtccccaaa 404100
gtccactgta tcattgtgag gcctttgcat cctcatggct tggctcccac ttatgcgtga 404160
gaacatactg ttataggatc tctggggtgt caatttttct gatgggaaac ttctgtggcc 404220
gcaacgcctt ttaagcccaa gtttttgtcc tgcgtccaga aagaatgagg tacacagaca 404280
tgtgaagggt gaaaaagaag agttttattt agtgttagaa caactcggag gagtggggag 404340
ctcctctcta taagcagatc gtcccattga gtgttcagct ctcagcagag aggaggccct 404400
ggaaagggtg gctcctctct gcaggcaagt cattctgcag gtctctgaag cactcctctt 404460
agcagagagg gtagctcctc tctgccagca ggtcatctct gcagctggtt gtcccatcgt 404520
ctccagctat cagcagagag ggtactcctc tctgcaactg gtcatccagt cccattctct 404580
ctctgccccc tttgtccctg gccatcctcc tgcctgctgt ggctaagccc agggctttta 404640
tggacctcag aggggaggaa gtatgtgcca attggtccat gggtggccat gggtggacgg 404700
aagaggcacc acgagtcccc actctggtcg gcaggactgg cagcccggcc cccagccttc 404760
aggccctccc tcgcctgaag gtggggccta attggggact cccctctttt ctgccccgga 404820
ccctgtcttc ctcctgctgc cattcatggc cccggggctt ggccccaacc cagctctgag 404880
atctgagtgg gtgcctggaa cggagagagg ccaggcagtg ggcgcagaca catctgagca 404940
tgcagagatg gggagggtcc ttcctggggc gcccaagggt gcaggctgca gagacgccca 405000
ggtcctgtgc ctgggagggt tggccacagc tgcacccggg agctcccgcc ctgacaactc 405060
ggaaggggca gggctcccgc ttgttcctgg ctcctgcctg cttcctggaa tgggaggccc 405120
aggtctgcag ccgtgggtgc ggcagctgca gctgcacctg ggaaggcaga tcctgcctgt 405180
tccaggctcc cccaagagca cagggagact cggatctaca gctgcagttt gggtggctgt 405240
ggccccaaga gggcggggct cctgcttgct ctgtggagca ggaggcctgg gtctgcagct 405300
gcagttcagg tggctgcagt ggcacgcgga gctcccatcc caactcggaa tgaacagggc 405360
tgccaccagc tccatggagt atgcagcacc agccgcgcag ccagcttgat ggcagcagcc 405420
actgccatca ttacggtgtt cagttttcca ttcctgagtt acttcactta gaataatggt 405480
atccagttcc aaacaggttg ctgtgaatgc tattattttg ttccttttta tggctgagta 405540
gtattctgtg atatatacat acaataattt atccactcat tgattgatgg gcatttgggc 405600
tggttccata tttctgcaat tgcgaattgt gctgctgtaa acatgcatgt gcaagtatct 405660
ttttcataag acgtctcctc tgggtagata cccagtagtg ggattgttgg atcaaatggt 405720
agttctactt taagttcttt aaggaatctc cacactgttt tccatagtgg ttgtattagt 405780
ctacattccc accagcaatg taaaagtgtt cccgtttcac cacatcccca tcaatatcta 405840
tcattttttt tattatggcc atttttgcat cttcgccctt cttgactact tttcctctct 405900
ctaaccaaaa ttatggtagg tgtttgctct tcttgccttt tgattgcctt tcttggatat 405960
ttctcccagt gtcagcttcc ctcccgggta ctggtgctgc ttctgtcacc ccgttccctt 406020
acctactctt ggtcctttca ggagagttcc tgtatgttta tcttagagcc acgtaaagct 406080
aaatgggtct tactatcttt attaacgagc tttattatct gcccctcctc tagcttagca 406140
ctctgtccat tctgtgtatc ttattgcagt tgtacctttc ctattcccac ctgagagctc 406200
ccactccttt ggttcaaccc agcttccatc aatcattcct cgagccttgc caattttttg 406260
tctctcttcc atgtttattg tcgctacctg agtctagacc ctctgggaac tgagctgatt 406320
ggattgcagt cttctgcacg gggagccatg gtgtagagtg gaaagtgtaa tggatgtgga 406380
gttagaaaga tcaaattctg gactcggtta agcatttaat taaaatgtct tggccaggca 406440
tggtggctca cacctgtaat cccagcactt tgggaggccg atgtgggtgg atcatttgag 406500
gtcaggagtt tgagaccagc ctgaccaaca tggtgaaatc tcgcctctac caaaaataca 406560
aaaattagcc gggcatggtg gcgggcacct gtagtcccag ctactcagga ggctgaggca 406620
gaagaaccgc ttgaacccgg gaggcagagg ttgcagtgag ccggggtcac gccactgcac 406680
tccagcctgg gtgacagagt gagactgcgt ctcaaaaagc aaaaaaaaat aaaataaaat 406740
aaataaaata aaataaaata aaataaaaaa taataaaata aaaataaaaa tgtctcaaac 406800
ccataggacc ttagtagtgc atatttgtct ctaggcctgt ttcgccacct ataaaataag 406860
ctgcatttta taaatggaat aactataaat gaatataaat cgatgtggaa tttgcataaa 406920
ttccatatag atttgggttt cttggcctta tgctgaaacc agcatttgag actgttggtg 406980
aaaagaatat aaagaggtgg tgtggtgtac atattactgt ccgtattatg gtctgattgt 407040
caccacagtc ctccatatta gctttttata tgacccctgc tttcccaatc tagatctcca 407100
gaattttttt ggtgtttttt gaatataatc aaaagtttgt tttgctcaag attcatcttc 407160
ctaaaaatgt ttgacaaatg cctaatttga aaattagttt gctgtcttca agcttctctt 407220
aggaaagaaa cgtggtccaa aagaagtttg tctagtatgc agggattttt aaaaactgga 407280
taacccaggg tggtctgcat aagttatatg cttttccccc aaagaatttc aaacggcttt 407340
cctggtatca tttgtcctta tgtttcttta gttccaggac agttcatact gttcttggca 407400
gcttacaaaa tgagaaactg aggtattgta attcagtcta cttcccttcc aaggaaaatt 407460
gaaaaacact gtggggaaaa tactaacaat tatgtgagcc tcaactttag attctgaaaa 407520
atttattcat ggaaagcaaa aattcattac tattcccata acattgccaa cagcaaagag 407580
attatattca gaattaaata cagccctgtt ccatttcttc tttgctttga aactcagtgt 407640
gagacagcag tggaaccttt tctgacttaa ggccaaatta ggtcaaaaac ctttgctttg 407700
aaccttctga gtcatagaat aagcagggag gaggaagaaa atccgtgacc tgtgccacga 407760
ttttttactg aggttttgtg caaagagtgc cgtgggcagg aaatgtagga agaagagagg 407820
acatcacttc ttcagtgttt ccctgtatgt ccagagatag gaaattcaga catttgcttt 407880
atttgctaaa cttcacagat gtgagcaaga ggaatattag aggcaatgtg tctaaattac 407940
ttacttcgat gtaatgactt cagagctctc aggaggagaa tggtcgcggg gaaggaacga 408000
gcccaaccaa tggcatgccc agagtcagcc cttcatctgc agttttaaga agtggtggtt 408060
ggagcaagac gtgtttgcag ttacaggaat aagcaggaga gggcagctca agttgcccat 408120
caaaagggtg ggtgaggggc tgggcgtggt gcctcacgcc tgtaatccca gcactttggg 408180
aggccaaggc gggtggatca cctgaggtca ggaattcaag accagccttg ccaatacggt 408240
gaaaccccgt ctctactaaa aatagaaaaa aattagccgg gcgtggtggc gcatgcctat 408300
aatcccagct actcaggagg ctgaggcagg agaattgttt gaacctggga ggcagaggtt 408360
gcagtgagcc gagatcgtgc cacttcacac cggcctgggc gacagagcga gactccgtct 408420
caaaaaagaa aaaaaaaaaa gggtgggtga gtattcctgc aggaagggga agattgagca 408480
gagaaaaatg tcatcccttt cttatccatg gggcttctcc tcccccacca agctcatcca 408540
tcagggtcga cactgctctt gtttgtgtct tcgcttagaa gagcctgcta gaagagtggc 408600
agatgagtca cctgtcacta aaagtaggtg ttcttagtgc tggggaaaat ggaaggtggc 408660
agcaaattcc tgctgcagtt ttccgtaaaa ttggattacc actactggtt ttaggtgccc 408720
ctggttttag gtgctctgta tgtaagtttg tgcaaaagta cagcggcatc tgtgggcatc 408780
caagctgggt tctgctctca gcaaactgaa gcaagcccag gccagtccaa gggaagatgg 408840
ctgtggacct tccttctgtt ttatgcagcc tagtttgagg cagttcaact gccccagagt 408900
taaacagttc accatacata atagaggact tcgtaattaa aataaatacc tctccaccaa 408960
gagaggagaa aaagaaagat gtgcacagtg tgatgcagaa atgcaaggtg ccctaaagtc 409020
aaatatgtta caggacacag tgtgcagctg tcagggcctc tggccagtct ccagctatgc 409080
tggaggtatt ttctgtgctc tgaccatagg ctacaagacc acatggctgc tgctccactc 409140
tgtagagttt cttgcatatc agaaaatctg agacctgaca tttgtgatga atatttcttg 409200
tacccatcac aaatcagaag aacaacccag agaggatgtc aggcacctgt tggtctttcc 409260
tcttgatcta cttgttgcct ccaagcaact aaggttcttt ttagagctct cacccctcaa 409320
agtgtagata attatattat cctctaaata tctaaaaact ttgtttaaaa ggactcgatt 409380
ttgttttctg ggaaaagctt ggtttaatac aaacaaattc catgtgtaac ccagctttat 409440
aaaatagaag ggtccgagtg cggtggctgt aatccccaca ctttgggagg ctgaggcagg 409500
tagatcagga ggtcaggaga ttgagaccat cctggctaac acagtgaaat cccgtctcta 409560
ctaaaaatac aaaaaattag ccaggcatgg tggcgcacac ctgtagtccc agctactaga 409620
gaggctgagg caggagaatc gcttgaaccc aggaggcaga ggttgcagtg agccgagatt 409680
gcaccactgc actccagcct gggcgacaga gcgagactcc atctcaaaaa aaaaaataag 409740
tgaaataaga tagaaggaag ggggtctggc tttattgtgg agggcactgt tttagggagg 409800
tacatacatg aatatgttcc tccgtcaggg aactgagggt ccactgcact gattctcaac 409860
catggctgca cattgaaatc actgataccc actccgaccc tataggttct gagttcagtg 409920
gcctggagtg tggtgtgacc ggcaagactt ttcaaaatct ttccaggtga ttctcctgtg 409980
ctgccaaggt taagaagcac aggtctagtg tagtagttcc ccaacctagc tgccaatcag 410040
aatcaccaaa agagattttt aaaatacaga ttcctaggtc ccagcccaga cctacacaat 410100
cttgggaaac tacagaggat gtgtattttt acagcatcac atgtatttct gattatcgac 410160
tcaggggacc ctcactgtaa tgtcctcatg cacgattgtg atcttaaagc ataatgcctg 410220
tagcagtttt tatttattta ttctcgtaga cgaagctgtt tttcactgct tcaagtttaa 410280
tggccaagtg tgtttgtaat tgtggttttt tgttttttgc tttttttgag acaaggtctt 410340
gctctgtcgt ccaggctgga gtgcagtggt gcaatctcag ctcattgcaa cctccgcctc 410400
ccaggttcaa gtgattctca tgcctcagcc tcctgagtag cagggattac aggcacaagc 410460
caccatgcct ggctaatttt tgtagtttta gtagagacgg gggttttggc atgttggcca 410520
ggctggtctc gaactcctga ccccaagatc cgcccacctc agcctcccaa agtgctggga 410580
ctacaggtgt gagccaccat gccgggcctc ctgtaattgc ttgttaagag aatcagacac 410640
ctttctgaag ccactaacca accagcagca ttccccattc tatgagcgct tttcctttct 410700
gctttcttgg cacatttctg tcatagacct cgttctcagc cttgttgaga cacctccttt 410760
agtttagtgt ggagtatttt cctagaacac cgcagccaga cgtcccccgt tatccgcagg 410820
ttgatttctg aggccaactg cagactgaaa gtatgaaatg gaaaattcca gaaataaaca 410880
gttcctaagt tttaagttgc gtgctgttct cagtagcatg ataaaatctc acgccttacc 410940
ccatcctaac gcagacgtga atcgtccctt tctccagctt gtccgctgcg cagcgctccc 411000
cgccggtgag tcacctagcg gccatcttgg tgcttagatc cactgtggtg ggatggaagt 411060
gcttgtgttc aagtcacctt tattttactt aatgatggtc ccaaagcact tagtgatgct 411120
ggcatactgt tacaatcgtt ctattttatt attagctatt atcattaatc tcatactgtg 411180
cctaatgtat aaatcaaact ttatcgtagg tatgtatata taggaaaaaa acatagcgta 411240
catagggttt ggtactatcc agtgggtttc aggaacccac tgggggtctt ggaacctatt 411300
cctcatggat aaggcgggga ctattgtact gaaatctgac aataactctg ccatgatgct 411360
tcttttgagc cacaaaggga gccctcgatg tgccttgctg tggtcatttc ctttaaattc 411420
ccttgctgtg atcatttcct tccatccagc ccagcctgag atgtggagac taccagacag 411480
agcctcgtgt gatgctctgt cggcttgagt gtgaggaagc ttgtaaatcc atgcgttttg 411540
ttaaaacatt atcttctaca gtgtcattga gggaagtttc aaatcagctg tgaaagaaaa 411600
caaaacccac ccatctaagg cattactcat gcctggctgt tcctggcttg cattagactc 411660
cctggctggt cccttcaggc tctccgttga gagctttctg tgaagttctt tgtatatttt 411720
cccaaatatg tttattatgg gttcatttta tcttctacgt tggaaacgtt atagattgag 411780
actcagtcac tgccttattg ctgcttttca tcatcccacc caccatccct tgggttaacc 411840
agagcaaaat agaagcaaac tatattattc gcgaaactat agcagggaaa aagatccaag 411900
tttctggaac gtgtcctgat gaaaaaataa gagtgcatca gatgtggaga taaaatgtct 411960
caatgttgaa gggatgcatt tatctactta acactcagat gtttttctga tggaagcctc 412020
tgcttattta tattttagca aaggccaaac taacctgttc taagaaataa tctcatactg 412080
aaagagagac ctcacttccc atttcccaat ccaaagtaaa tgctgtgaaa gaccaggaat 412140
gtagtaccgt cagcacacat ctgggactgt ttgtagccta cgttctgaaa tcaggggatg 412200
ctgacaggct caagctgcga tactgaaagg aggcctggtt tcccttctgt tggaattaca 412260
ttacaaggag aaatattgat ccagcatact caagaatggg ctgggtgtgg tagctcatgc 412320
ctgttatccc aacactttgg gaggctgaga caggcagatc tcttgagccc aagagttcaa 412380
gacaagcctg gacaacatgg tgaaaccccg tctctacaaa aactacaaaa attagctggg 412440
cgtggtggca tgcgcctgta gtcccagcaa ctcaagaggc agaggtgggt ggatggcttg 412500
agcctgggag gtcgaagcta cagtgagcca agattgggcc actgcactcc agcctgtatg 412560
acagagtgag accttgtttc aaaaaaaaaa aaaaaccctg aaattaaaaa aacattcact 412620
gggggaaaaa ttggtttctt agtagaagaa taccagcaaa actcaaaatg aaaatggaaa 412680
tgctctgctg ccaatcagga aaagactgaa aatcttggca gaattctgct ggaatcctct 412740
gcccatttcc ttcatgttct cataattata aaagaaaaag aaatgaacat tgataaagtt 412800
cctgctgaat aagagaagtt ttttctacct cacatttgtt gaatgcatct catttagtca 412860
tcaccctaac cctgtagggt acgtgttatt atctccattt tctttatttt ttgagacagg 412920
gtcttgttct gtctcccagg ttggagtgca gtgccgcgat ctcagctcaa tgcagctttg 412980
atctcccagg ctaggctcaa gcaatcctcc cacctcagcc tcccaagttg ctgggactgc 413040
aagcatgcac caccacacct gcctaaattt ttttattatt ttgtagagac aggcctcact 413100
ttgttaccca ggctggtctc gaattcctgg cctcacatag tcctcctgcc tcggcctcct 413160
gaagtgctgg gattacaggt gtgagccacc acacccagcc aattcccatt ttaaaatgag 413220
gaaaccaagg cttgggttcg gtgatttgct gtgactgaaa atccttccct ccccacaaat 413280
agggacacca ctatcagata tcacatagat catttcccag gagccaaggg caaagggcag 413340
acccgtcttt ggccaaagcc aaattctttc ctacacagta aatatgggaa aaagagagac 413400
ttcaagcttc accccaagag ttgagacatt ttgaagaaag actgacacaa ttaggggagt 413460
cgctggatat aggagtgaag tgcgagagag gtatcaaata tcaggctctg gcctatgctt 413520
ggagaaatgg tgcaaaaccg ttagcagaaa tatggaaccg gagtgcatgc tgatttgaga 413580
ggggtggtaa gcatccaagt ggaaattcct cacagactct tgagctgaga ctgaagttca 413640
ggaagaagaa cacacctgga ttttttttct tatgctaggc attatagttg cttttatttc 413700
atctcaacaa tcttttgaaa acgtattatc atcattcaca tattccagat gaggaaactg 413760
aggcttacag aggttaactg catcttccac gtccacagtg ctagtataga aaatgagctt 413820
tgttgtaaac aggagactgc cttacttttt ttgcatttcc gcttgtccat taaatatttt 413880
attgcctgtt tagattacag tcattggtgc ctacagcagc attatttatc tttcattggg 413940
aattagggcc ttaaattaaa tcgttagtca tattttatgt ttttataatg ttgtagagat 414000
tctagttagg gcatggtatt ctaaaaagga aaagcattga tttaatttat aatgaataat 414060
tgtatctaaa cagtgtacta tgtgttctgc gttcaaataa gccagaaagc ttctatttat 414120
accaaaggaa taaacagcaa acaacagaca tacttaaatt gaaaacatga gcacatttga 414180
attttatttt tgaatgtaga tgtaattgac catttgttct gcaaacaagg ctttggtcca 414240
gtttaggggg aaaaaaaaat cagtgcacta gtgtggagta ttttctaaaa gaagacaatt 414300
ttagagactt agtaaacttt ctgaaccggt aagacttgaa atgcctcatg aagggaagtg 414360
aggcagggaa acttttaatg agagattatt ccattcacca tctttgctgg agctgactgg 414420
tgtctatgat gcaggaagta acctgagaaa gaattctagg gaggaaaatg tgtttttttt 414480
ttttctttct ttcttttttg agacacagtc tcgctctgtc accaggctgg agtgcagtgg 414540
catgatctca gctcactgca acctctgcct cccgggttca agtgattctt ctgcctcagc 414600
ctcccgagta gctggaacta caggcacgtg ccaccatgcc cagctaattt ttgtattttt 414660
agtagaaaca agatgtcacc atgttggcca ggatggtctc gatctcttca tctcgtgatc 414720
caccagcctc agcctcccaa agtgctggga ttacaggcgt gagccaccat gcccagcctg 414780
aaaatgtgat ttttttatgc agatgaaaat aggaccacag tgaaggaggt agagaagagg 414840
gcctttctta gaaaataatc ggaacaacca cagccagtaa ttgtaggtct tgagtacgcc 414900
aggccctcat ctaaattctt cttatgtgtg aactcacagc aagcctgtgg ggtaggaact 414960
agtattattc ccactttgga gatgagcaaa ctgaggcaca gagaaatgaa ttagttaggc 415020
ctggttagta cttagatcag agaaattaat taacttgcat cagatataca cagctgagga 415080
gtaaggccac caggattcca aatcaggtgg cctagatccc aggcctgtgc tgtttgctgc 415140
agcagtcata ggaggtagtt tgaactggaa agcagttcat catgagaggt agcatttttt 415200
gaggcactac tgcctgcttg catgctaggc actgaattgt cccatgcaat tctcataaca 415260
acttcatgaa ataaggcgta ttactatctt catttttttt tttctaaggc agagtttcac 415320
tcctgtcgcc caggctagag tgcaatggta caatcttggt tcgctgcaac ctccacctcg 415380
cgggttcaag tgattcttct gcctcagcct ccctggaatt acaggcactc accaccaagc 415440
ccggctaatt ttttttgtat ttttagtaga gacggggctt tgccacattg accaggctgg 415500
tctcgaactc tggatctcac atgatctgcc ccccctcggc ctctgaaagt gctgggatta 415560
tatgtgtgag ccaccgtgcc tcgccatact atcttcattt tcttaaagag gaaatcaaag 415620
cttagaaagt tgaatgggcc cggtgctgtg gctcatatct gtaattctaa cactatggaa 415680
agccaaaatg ggaggatcgc ttaagcccag gagtttgaga ccagcctgca cagcgtgatg 415740
aaaccctatc tgaataaaaa agtttaaaat gtagctagat gtggcggcac aagtctgtaa 415800
tcccagctac taaggaagct gaggatcact tgagcacagg gaggtcgagg ctacagtaaa 415860
ctatggttgt gctactgtgt ccagaattag gtgcgttctt ggtctcactg acttcaagaa 415920
ttaagccgtg gacccttgcg gtgagtgtta cagttcttaa agcggcatgt ctggagttgt 415980
tcattcctcc ctgtgggttc atggtctcac tggcttcagg aatgaagctg cagacctttc 416040
cggtgagtgt tatagctcat acaggcagta tagatccaaa gagtgaacag cagcagcaag 416100
atttattgca aagacaaaaa gaacaaagct tccacagtgt ggaaagggat cggagaaggt 416160
taccactgct ggctcgggca gcctgctttt attctcttat ctggccctac ccatgttctg 416220
ctgattggtc cattttacag agagcccagt ggtctgtttt gacagggtac tgattggtgc 416280
atttacaatc cctgagctag acacaaaggt tctccagggc cccactagat tagctaaata 416340
aagagtgtcg acacaaaggt tctccaagtc cccaccagag tagctagata cagagtgtgg 416400
attggtgcat tcacaaaccc tgagctagac acagggtgct gattggtgtg tttacaaacc 416460
ttgagctaga tacagagtgc cgattggtgt atttacaatc ccttagctag acataaaggt 416520
tctccaagtc cccaccagag tagctagtta cagagtgtgg attggtgcat tcacaaaccc 416580
tgagctagac acagggtgct gattggtgtg tttacaaacc ttgagctaga tatagagtgc 416640
tgattggtgt atttaaaatc ccttagctag acataaaggt tctccaaggc cccaccagac 416700
tcaggagccc agctggcttc acctagtgga tcttcacaga ggcagtaggt ggagctgcct 416760
gccagtgccg tgcgcccgca ctcctcagtc cttgggtggt cgatgggact gggcgctgtg 416820
gagcaggggg cggcgctcgt cggggaggct ctggctgcac aggagcccac ggaggggcag 416880
ggggaggttc aggcatggcg ggctgcaggt cccgagccct gcccgccaga aggcagctaa 416940
ggcctggcga gaaattgagc acagcggctg ctggcccaac tgctaagccc ctcactgccc 417000
tagggccggc ggggtccgcc gctgctccga gtgcggggcc cacggagccc acagccacct 417060
ggaacgcgcg ctggcccaca agcaacgcgc gcagcccggg ttcccaccca cgcctctcct 417120
tccacacctc cgcgcaagct gagggagccg gctctggcct tggccagccc agaaagaggt 417180
cccacagtgc agcggcgggg tgaagggctc ctcaagagcc gccaaagtgg gagcccaggc 417240
agaggaggcg cagagagcaa gtgagggctg tgagggctgc cagtatgctg tcacctctca 417300
ctacactcca gcctgggtga cagagtgaga cccggcgaca aaaaagaggg agagaaaatt 417360
gaaagacttt cctaaagtca cgagttatca aatgccagtt agcccggtct aacatgacac 417420
tgaatcaact atgtgcttcc tgctcaggag tcagaacgat attatcaagt gttaatgctt 417480
ctaaatgcaa agagggagca aggtgtttct tctctttagt ctgtgaccag cagctgctca 417540
ctataacctc tcttccactg catgtccaag gattactgca tagaggagga ttcccatctt 417600
cccagcccct aaatttaaaa ataaattaaa taggctgagc gtggtggctc agggctgtaa 417660
tcccaagcgg tggctcactc ccactttggg aggccgagat gggcggatca cctgaggtca 417720
ggagtttgag accagcctgg ccaacatgat ataaccctgt ctgaaaaaag tacaaaaact 417780
agccaggcat ggtggcaggc gcctgtaatc ccagctactc aggaggctga ggcatgagaa 417840
tcgcttgaac ccaggaggcg gaggttgcag tgagctggga tcacgtgact gcgctccagc 417900
tctggctact gtctcaaaat aaataaataa ataaataatt aaaagaatat agaaccgccc 417960
tcacacttcc tgccggatgc agtcaatttg acagtgtgcc tcattcagag ggtgttgcct 418020
acatccaggg agtgtcaatt tttttttatt gaatgaatac ctgattaagt taatgacgct 418080
gagctggggg aggaggagca gtttggcagc ccaatgctga agggcttctg gcagctcatt 418140
cagtgtcctt aatgttccat tggctttgtg ctgggccgca tgtgagcccc aggagaggct 418200
gctgtaatta ctcagctttt ttattgaaaa cagctgcagg tagcgagtca tcccattgtc 418260
catcttgcta gtgactggaa acaactcggg gccatcttgg gctccactac actgcagcct 418320
cattctgaag tcagtggagg tagaaagtag gcttcccact tgctgggctt ttcaaaatga 418380
gccattcatc ttttgagggt cagaagtcag ccacccattc accgagtgtg agtcataccc 418440
ctaattttaa aacaaacatt tattgcagag agaattctta tcttggccga tgtgtacagc 418500
tgatctcctt gtccttccta cgattgattt aggctggttt caacaaaatt gttgtctttg 418560
taaatacaca cctcttccag taaatccaga gactaccgag gtgtttcctt gagattgagc 418620
ctaagacaat ctttaattag ttttggataa ttggatatga atgtttagag gccttcccat 418680
atagcaagtg tctttaacat ctcacacaat atattatact tgtacttcct gacccgagaa 418740
gtaacaggag ttaataatct cacgtgagaa agtatgtttg aaatggaatc tcaaggggca 418800
gattctttgc agataccaca acattatttt atgtccctcc gtaatgagtt cagtttttta 418860
tcatcacatc caaaatctag aaaatgatcc agaaatcctt tgccttttaa taaccagctt 418920
gtaaggaaga caaactgcaa gagatggaca caagataaga acagtaacca accaaggacg 418980
gacagcaccc tagaaaccca aggggttgtg aacttcagtc tctaagcagc atcggagttt 419040
acggtctaat gacgaaaaca cgtgaaaaca aggattgcag cagccggaag tggctttgct 419100
gagagtttag gaatgattgc ctaaggaagt agcagttagg ggacccactg tattagtcag 419160
ggttctctag acagacagga ctaataggat agatgtatat atgaagggga gtttattaag 419220
gaatattgac tcacatgatc aaaaggtcaa gtcctacaat aggccacctg caagctgagg 419280
agcaaggaag ccagtggttg accagtctga gtcccaagac ctcaaaagta gggaagccga 419340
cagtgcagcc ttcagcctgt ggccaaaggc ccaagagccc tggccaacca ttagtgtagg 419400
tccaagagtc caaaagctga agaacttcaa gtcgggtgtt cgagggcagg aagcatccag 419460
cacgagaaaa agatgaaggc cagaagactc agccagtcta gtccttctac gttcttctgc 419520
ctgctttcat tctagcctca ctggcagctg attagattgt gcccacccag attgagggtg 419580
ggtcttcctc tccaagccca tgacccaaat gtttatctcc tttggcaaca ccctcacaga 419640
cacaaccaag aataatactt tgcatccttc aatccaatca agttgacact cagtattaac 419700
catcatgccc accatggtga aggcatgcgg gggtggctgg tgttagacta attggagcct 419760
tggaggatag tcgaggaaac ggttcctgaa cggtgtgtgg atgagaatgt tggagcaggg 419820
tgctaaggag gcacagagga gaggcagagg gtatggggtt ggagtgggga gagccttaag 419880
gaggtgacat ggaaggagag acctgaaaga tgggtgaggc cagtgcttct ggaagtgtgg 419940
ttcctggacc agcagcatca gcagcatctg ggaactccgg gtgaatgtga tgcgcacgct 420000
cgagtataag aaccactgca ttagaaaaca ggtgacagtg ccttgcggag gagcggtggc 420060
tggtgtggaa agtactctaa cagagcagag ggaacacata cccagaggcc tgcagcaggc 420120
atatttgagg cttgatcagg acacagccac ccacacccac tggttacaaa ttatctgtgg 420180
ttgctttcag cctgcagagg tagagctgag taatggccac agaggtgtat ggcccgcaaa 420240
gccacacgat ttactaggtg gccgcgcatc gtcaaggttt tccagtccct gattcagagg 420300
gtggaactga cataacctga tgacagaatc aggggagaag aggcatacag ggatatcggc 420360
cagctttcag tcttcagtga gcaatgacat gatagagcag tgacactaag atactgctgc 420420
ctcacttttt acagctcaca gtcccctttg cggatgtgag aaagggcata cagctttaag 420480
ggcttaaagg atgccctgac gtccagtcct ggaatacagg ctaatgccag caggtatctc 420540
agagatcctt gtagctccaa gcagatgagg gagcggggcg ctgtgtggtt tcaaaacaga 420600
aatgcagttt gttcacaaac ttttaagatc atgacatatt tatttattta tttatttgag 420660
acagagtctc gctctgtcac ccaggctgga gtgcagtggt gcgatctcag ctcactgcaa 420720
gcctgcctcc caggttcacg ccattctcct gtctcagcct ctcgagtagc tgggactaca 420780
cgtgcccacc accacgcccg gctaattttt tctatttttt agtagagaca gggtttcacc 420840
gtgttagcca ggatggtctt gatctcctga ccttgtgatc tgcgcgcctc agcctcccaa 420900
agtgctggga ttacaggcgt gagccaacgc gcccagccat gacatactta tttttaaaaa 420960
tttttgactg gtgacaaaat atgcataata tgaaatttac catcttaatc atttttacgt 421020
gcacggttaa gtggcacatt cttgttcaac catcaccacc atctgtctcc agaatgtttc 421080
catcatacca aactgaaatt ctggaaccgt taaacaactc ccattgcccc gtcctcccag 421140
ctcctgctaa cgcctgttct acgctctctc caaatttgac tattctagat tcctcataga 421200
aggggaatca tatgatattg ttcttttgtg tctggcttct ttcacttagc ataatgtttg 421260
aagatttatc aatgtcatag catgtaacag aatgtcattc ctttgtaagg agagggggat 421320
gaataatagc tcgtcataag gatataccac atttttaaag tttattcatc tgttgatgat 421380
cattgggttg ttgacacctt ttggctcgtg tgcacaatgc tgctatgaac acgggtgtgg 421440
aatatctgag tccctgcttt cagtgctttg tggtagatat ccagacgtgg aattgctgag 421500
tcatgtggta attctgtatt tcacattttg aggaactgcc aaaatgtttt ccatgcagct 421560
gcatcatttt acgttcccac caacgatgca cataggttct cgtttcccca tctccaccaa 421620
cacttgctat tttccatttt tgttttgttt ttttttttaa aaaaaagaat ataatgtcca 421680
tcttaatgag tgtgaagtgg tgtctcattg tggacatagc atataatttt aagtatgatt 421740
aaaggaggtt agaacacgac ttttgtgttg gcaaagtggg gaaaaggatt ggctgctgta 421800
attaaaatca ctgagacagg ccgggctcag tggctcacgc ctgtaatccc agcacgttgg 421860
gaggccaagg taggtggatc gctcaggtca ggagtttgag accagcctgg ccaacatggt 421920
aaaaccccgt ctctaccaaa aataaaaata aaaataacat agccaggtgt ggtggcaggc 421980
acctgtaatc ccaactactt gggaggctga ggcaggagaa tcacttgaac ctgggaggtg 422040
cagtgagccg agactgcacc cattgcacac cagcctgggt gacagagcga gactccgtct 422100
caaaaaaaaa aaaaaaaaaa aaatcactga gacatactgc caaggacaga tggagttagg 422160
gggcttaaag atcctctata ccagccgggt gcggtggctc acgcctataa tcccagtact 422220
ttgggaggcc gaggcaggca gatcaagagg tcaggagatc aagaccatcc tggctaacac 422280
ggtgaaaccc catctctact aaaaatacaa aaaaattagc caggcgtggt ggtgggtgcc 422340
tgtagtccca gccactcggg aggctgaggc aggagaatgg tgtgaacccg ggaggtggag 422400
cttgcagtga gccgagatca cgccactgca ttccagcctg ggggacagag cgagactctg 422460
tctcaaaaaa aaaaaaaaaa aaaaaatcct ctataccaga ggttctcacc tctggctgca 422520
aattagaatc ccctggtgca tttcctaaaa tgccagtggt ggtcccaaca tctagggatt 422580
cttattcagt tggtctgggg tagatctgga cattatgttt ttaaaagctc cctgggtgag 422640
tctgatgtgc cgtcagcatt gatttcttat tctgcaggtg agagagtatg gccctagtac 422700
taaggctgca agggttctgg tctctcagcc agagctgctg ccactgatac accattattc 422760
agcatgacca caaacacagt gaaaccagta gtgtcccagg tacatgtgca tcctcctttg 422820
tattgtggag gaaatatgtc cccaaaatct gcagagccaa gtgcgggagc caactcctcc 422880
atttggtctg ttgggatgtt cagtattcta tggtagattt ctagtaagtc aatttcactc 422940
agtgggctga ggatattaag acaccggaag ttagctgatg tgttccccca ttgctccaac 423000
actttgaact ctgtacccca aaaattgatc cactcagtgc ttcttacatg tatgtgccat 423060
tggggagatt tccacaggga ggctttctct gagcctttgg ccctggtgac attacactga 423120
gtaatatata tccctgttcc tttctgtacc acccatctgc ctgttccctg gccacagttt 423180
ggggtatacc aatttagatt aacctaatta ttgtttcaca aggcattctt atcactgaac 423240
gctgatggat gttacttcaa cgttgttata ttttattact tggcctattt aagtgtataa 423300
ccatcactag ctataagaag gtgaccaact acaacgttag agagagcagt gcctgcacca 423360
cgaattgcaa gttcaggggg tttcccagac caccctccgt tttgataatt cagtaaaagg 423420
actcacagaa ctcactgaaa gctgttctac tcatacttat tacagggaaa ggatacaagt 423480
taaacttagc cagggtaaga ggcatatagg agaggtctag aggggtccag acatggggct 423540
tctgttgccc tctgcccatg aagtgatgaa cagcattacc tcctcccagc catgatgtga 423600
agaatcacca accagggaag ctcacgcgaa cctcagcatc tagagttttt attggagctc 423660
aattgctact gtcctcatga ctgacctcta gtccctaggc cctcctggag atcaggcaaa 423720
tatctttcat tattagttcc tctgaggttg gaacgtatac ctcatggccc aaagccccca 423780
tcataaatca cattgttact ccatccagtg gccaataaac atacttctgt gaggcaggac 423840
attccagagg ccgagagatc acctccccac aggtgggggc aaaggccaga cctgagtttg 423900
ggtgaggtta aattcttcat ggtcaggcgc ggtggctcat acctgtaatc ccagcacttt 423960
gggaggccga ggtgggcaga ccgcgaagtc aagagatcga gaccatcctg gccaacatgg 424020
tgaaaccctg tctctactaa aaatacaaaa attagctggg catggtggca tgcgcctgta 424080
gtcccagctt cttggaaggc tgaggcagga gaatcgcttg aacccaggag gcagaggttg 424140
cagtgagccg agatcacgcc actgcactac agcatggtga cagagtgaga ctccgtctca 424200
aaaaagaaaa aaaattcttc actacacact aatgacccac tacacaaccc aagaactaga 424260
tcccaagttt tcatattagg attttttgtg tgttgtttct gccctttttt agccatgtaa 424320
tcttaggcaa gtgacttaca ctctgagctt caatgtcctt gtctttgaaa tggggtgatc 424380
atatgctagt tgttatttat atgtaaagca ttgctgtagc ctgcacaaat taagcatcgt 424440
gacttgtcct gcctgctgtg ccttagagag cctgggtccc gggaggtctt ggggtctttg 424500
cagttgagag cattgaattg tgcagtgtct cagtgactga aaccaccata gaaggtaagc 424560
cagtgtgtga cacctggagg aacagctggt tagtttatga attatctgga ggcattggct 424620
ttgctttcat tcagccacac caaggacagt gaatagtttt aagactctcc cagagtacct 424680
cagttcccac gagacctttt tcctgacttg atggagagtt ttatgttctc tgttgtagac 424740
tggggctgtc taatgtcctg gaaacccagc cccctggtgg ctggcaggat ccagcctagg 424800
cctcctggag cagttgctgg cgctttgcat cgtgttgtgt ggtgaagctc gtgagtgtgt 424860
gtgcgggtag acagctggca gccttccctg cgggatgtgg aaggaggatt ctgcatttcc 424920
ccaccatgcg tcttgggaat tactcatcca aaaagtattg tggaaaagca ggcagagtga 424980
aacacggagg cattgcactt aacccttccc tggaaatgcc atccttgagt ttagcgtctg 425040
agctttctgt ttattctgct tgtgtgctga attgccttcc ttcttgttgg tgtgcatagg 425100
ggtctgcaca ttgggcactt ataaatatta tcccacctat caagtgaaga aaaaaatgaa 425160
ctctcaaaca cccatcactt cctctttttc tatcacagat gtgaggaaaa aacagatgtt 425220
tgaaagaatt gatagtttga aggtgttgta ttgattacat catggccagg agagatgagc 425280
aacagataag tgtgggtgat cactgagaat tcatgaggaa atgtttattg aattataact 425340
acgatggcga ccatgtactg agtgtgtgtt atactaggca ctgtgcatgt taattcttcc 425400
ccattttaaa ggcagagatt acaactttac acattgttga aatgaaattt ttgcctcatt 425460
aaacttgggc acatgtataa tcgcaagtaa aattaaaatt attattttga gatggagtct 425520
cgctctgtcg cccaggctgg agtgcagtgg tgtgatctcg gctcactgca acctccgcct 425580
cctgggttca agcgattctc ctgccttagc ctccctcgta gctgggacta caggcgcctg 425640
ccaccacgcc tggctcattt tttgtatttt tagtagagac aggatttcac tgtgttatcc 425700
aggatggtct caatctcctg acctcgcaat ccgcccgcct cagcctccta aagtgctggg 425760
tttgcaggca tgagccacca cgcccggcca aaattatatt tttaaaaatg gataacatag 425820
gtggtttggg gtaaagccaa ggtttgaacc tgttctctac cttacggcgt agcccactct 425880
aactacaatt ctgtgtgtcc ttagtagtaa tagcagtgga atattattga tctattatca 425940
tcattgttag taataataat attaatattt atcttgatat tctaaatagg acagtggatg 426000
tgaatgcttc atgcatcggg tagtgagatc tatcacagtg gtggtaagaa acattcaagt 426060
gagagtcaaa gtgacaggtt ctcatcctcc tgaccccagt tcttactgtg ttaccttggc 426120
caatactttt catcttcttg catcagtcct tgaaataaga taatgaagag ggctcacttc 426180
ctctcacttt gaaacaagtt agtctggact gggatgagaa ccactaactc caggcagcgt 426240
ggaaagcatc tgtgtaactg ttcccagcct tcaaccagag tggtggataa acagaaacgt 426300
gggtgccccc gggtagctaa cctggaatgc actacgcttt aaagcaaaaa agtatttgct 426360
tctgtattga atcaggaaag gtcttgacag aaaggcattt ccagcttttc ttaaaaactc 426420
caactcaacc tctgtcagac aattcatttg ggaccagctt ggatccagat ggttattttt 426480
ccatcttgag cctttccagg aattccggca tgggcaggcc gccagagaca ctggctacac 426540
agccactgca gcgcgttttc catgtgagcc ggcttctagg gatggcccag ccaagctgtg 426600
gccccgcccc tcctccttcc tcatccaggc tgatcctcca gctctcacgg acatgtgcca 426660
tgagccacgc agggggaccc cagccacatg gccgatgtcc tgatgtttcc aggggtggca 426720
gagctcacta actgcacccc cagaactgtc atctgctcac tacgaatagc aatggcagaa 426780
gccaggaatc taagaattga tgaagcctgg ccctccatta tgtggacagg tagtagcaaa 426840
tcactcagcc ccacttaggg ataagggaga cagcaactta accacgtgcc aagcagacaa 426900
gttcagcaga atggcagcca gtgcagctgt gtgtcttgag gaattctttc cagcctcccc 426960
ttcaaggccc ttaatcaaag aacaactccc cactggacgc agagctaccc aagccagcga 427020
ccacccgaat gagactatta ttttgggtgg atttaaattt tttaatcatt gcttcaagta 427080
tagtcgtatc cattgcccaa aaagtctata gatgcatggg gtcaaaaaac actactattc 427140
gtggtgctga taatataagt agtggggctg cttttctcct gcctttgctt gacccactgc 427200
agtcccagct ggcagtggta gtggcagatt cccctgaccc aaccaccccc aggaaggtct 427260
tgcctcaaag aaaaggaaaa tgtggtgtgt gctgctggct gccacggact caggggagcc 427320
tgtgccaggt tgcaggcttg aacttgcttc ttgtgacact agagggagag agcttgtttc 427380
aaaagcatgt tagtgctctc agttcctcac gtccgacctg tgccagaggc tccttctgca 427440
gtctcaccac tcctatggcc tggatcacaa ttgggtgggt ggtcttgaac ttggctgctg 427500
agcctgaggt cccctgcttg cttgcctggg aaatacaaac atcctgacct ctcttccttg 427560
gtcactgatc agtctcttcc ttactgaacg tctcaccagc tgcagttctt gattagtcaa 427620
catggtgcag aggtccccta gacatctttt cccctactta tccctgtgca ttctgtccct 427680
tttctacatg aaaaataaat aggcatattt gctatgaggc tgccatcgcc atagccagga 427740
ggtgagtgta acccgcatca tggttgggta gactaagaaa gtgatttcca gtgctagttc 427800
tacctctgac tgtatggcct tgggaaaacc tcagtgtcct tatctggaaa atggagataa 427860
taatacaaac ctcacaaatt tgttatgaag agtaaatgag atatttaagt aaggttcttg 427920
gcatgtataa taagtaatca ataaatggaa gatatttgga ttggtttctt agggctgcca 427980
taataaatta ccaaaacata tcgtggctta aaacaacaga aaagtattct ctaacactcc 428040
tggaggcttg aagtctaaaa ttaaggtgct ggtggagcca tgttcccttc ataggctcta 428100
ggggataatc tttccttgct tcttgctgct tctagtagct tcgggtgatc cttggcttgg 428160
gactgcgtca ttccagtctc tctgcctctg cctccacagg gcctttgcct ctgtacatct 428220
cacatctttc tctgcctttc tcttataagg acatttgtct ttgaattgag ggcccacctg 428280
gatcatccag catgatctca tttccaaatc cataattaca tctgcaaaga ccctttttcc 428340
aaataaagcc attcccaggt tctgagtggg cataactttt agggatctac cattcaaccc 428400
actgtccttc cttattcatg ataaaaatta agatacataa aattatttat tttttatgtc 428460
cttaggccct cgtgtggact ccttctagct tggattacga gctttcattt cttgcttttt 428520
ctcttctcac tcactacact tccgtgaaga gcaagatccc atgtcccagg ggtgcagagc 428580
cgagaaggga aacccgagcg cgttggggcg aggctctcag acagcatctt ctacaaagtt 428640
gtgccaggtc ccagctcgcc tctctggtgg tttctggcct ggatgtctct agacagggcc 428700
ttcagtcccc ttcaggagcc tcctcatttt gggccaagag gcctgcccca tgaagctcca 428760
cgcttagata gacatggaag agaaggtcaa tagtcagttt ccactgagga cacagcaaga 428820
agaaattgtg acagtagact gggatgacaa gccagccacc ttgacacaga gtggaatcac 428880
agtctcagaa tgttcctaat ggcaaaaaaa tgtagagtaa gtagttcgaa cacccaacca 428940
gggcagggac ccctacccca tatccctgag tttctatcct gacccttggg gtgacccaga 429000
gatccctgac tcatgaggca gcccagtcca tttttaacca ttctcattgc ttcctaatgc 429060
tgcagctttt tctgttcttc cccagggcac tcattcccag ttgtctcagc tgttactcat 429120
ctgcttgcct ccagacctct tgcgcaactg atcactcccc ctagacatgc cccatccttc 429180
ccacgtgcct ttgcagcagg atttcaactg tggctttacc cgtgccatct atggttgcag 429240
tatttattcc cttattctga acattgtttt ctttctcttt tcttgagaca gggtcttgct 429300
ttatcaccta ggctggagtg cagtggagca atcatggctc actgcagcct caacctcctg 429360
ggctcaagca atcctcctgc cttagcctcc tgggtagcta ggaccacaga tgcaaaccac 429420
catgcctagc taattttttt tattttttgt agagacagga tctcgatatg ttgtccaggc 429480
tggccttgag ctcctgggct cccaaagtgc tgggattaca ggtgtgagcc actgaaccca 429540
gcctgaacat tatatttttt ttaatgaagg ttataattac tatacttttt aagaacccta 429600
ccaaatggtt gttcatattg agtgtatagt caaacaaaaa ctttctgggc tctttcattg 429660
aaaccattat taaaccagat ctcttcaacc ctgctagtag gctaattgag ctgttgaaac 429720
caagggcagg catttacatt tattctcatt gatcttaatt ttcctggttt ggtaccatca 429780
cttccggctt cttaagatat atttgaatct tattcgcaac atatatccct tctagccttc 429840
tgttacttcg aaatatgata accaaaacac tgtattagta ttgaatagaa cagaactaaa 429900
aatagagttc tggcatacca tttgcttcac actgacattg aacaattgag gtccccgtca 429960
tacatactag aaacggaatg agtgtttgat gaatgaatgt gtgatccact ttgggggcat 430020
gcctgttcag tcaaccataa aggcatctaa ttatagctat catccaatcc acctttctcc 430080
attctagata ctccaagcat gtcgggtttg gacctgtttt taatgcttgg ccaaaatgaa 430140
gtgctttctg ccagtgcacc acacaggcct tccagtttag tgatgtaata aagctggaag 430200
gagattggtg agtcagcact ttgagaatcc ttgacatgcc caagtaacct ctgtcctcac 430260
acccaggtat tctgccctct tcagtgtttg catacgtagt ttttccagtc ctggcacaag 430320
ctcatcagcc tgctcttcct cttctttaaa gctgaaaccg tgccctgttt gtccatagat 430380
atacaggcca ggcagccatg ggttcattca aactgagaag cacaggattg ggggtgtagg 430440
aaaagcaacc cattttcttg ccctaggttt aagatgtatt tttaggagtt tatatatcaa 430500
attctaagag catcttccat tctgagcagt tggctgctat ttactggact tgcagtcagt 430560
gggcatatat tccccacatc cctagcacag aagcatctca ttttcctatc acttcccaag 430620
cagtctgaat ccatggtaat agcaaaaaat ttctcgaaat gaaattatag caaagaaaga 430680
agtgtggagc ttcctttgtt aaatttcatt tttcttcctg ggaatgattg agttgtgtat 430740
aaaatttatg ataatagcct ttttaaagta tatttctctg cagttgtgta aagaaccaga 430800
agaaaagcag catttgttat ttgcagccgt attaggttta gatgacccca gaggaagcag 430860
tggagcatca cctaaatatt agatgtttat ctccgaggct ccatcaactc tgtgtttacg 430920
tacaacacct agtttggttt cccagtgcct gctccattag gaagaggcta gagatgttta 430980
atttgcttaa gagtttagca gtagaaaatt taatcggata gctgctaggg tttctcaaac 431040
cttactgtgc atagaatcat ctggatatct tgttaaaatg caggactggg tggggcctga 431100
gagtctgcat ttccagcaaa cttgcagagg atgctgatgt cacgggtcgg aggaccacac 431160
ttcgactagc aaagccttat accactgggc taaatttaga aattatgata gagagatagt 431220
taatgtagct ctaaagcggc ttaagatgaa tgtattcaga acagtgatta tcaggcaaac 431280
catgggtagc aaactctaaa tacatttgtc ttgattcatc tattaactct ccctccaatt 431340
tcccttttcc aataggaatg tttaaacagt gcgatctgca tatgtggctc tctggtaatt 431400
tggcattgat ataattgtgc atggccccat gtttggaaga aatctttttg ttgtggcagg 431460
tgcttccaga gataaactcc tcgggggtcc cctgggaggg caattcagga cacagaggcc 431520
agttgtctgc aactagagac tctaagagca gaaatcccac tctccttttt tcttttttct 431580
tctttcgttt ctttttctct cttccttatt ttccaaatct acttttccac cttcataagt 431640
tacttctttg ttgtttagtc ccatgatcac ccgatagacc aggaatgtgg tgccatcctg 431700
gggcgccctc tggtggttca ttgaaaatac agcaagaccc aatctctacc cgtgggtttc 431760
cccttatcag tactgaaagc ttacggggcc cagagaaggg acacatacct cagcgttaga 431820
gagccctgtc tgctccgtgc tgcactggta aatagcccta aatgtaggag gaggatgggt 431880
ggaaactttt atcggtttgg ccccagctcg ctgcaactgc tgtcttaatc attgtgtcct 431940
tgatttctca ttggcaatct ctggaaaaga tgctgtttat caatggataa gttttcagaa 432000
gaataaattt ggatttgtgt gttaaggcca atatgtctta gcaatcattt cgcagaagac 432060
cagtccagtg agtcttcagg gctgactaag ccgatgtctc tcaaataaac agtataatta 432120
aacctgagca ctactgagaa ccaagtcagc attctttttc aaatttacga aagctggctt 432180
cctaaagaag taccttcaga ggagttttct agttttgtgt attgtgcatt caattgtaca 432240
ggcaatgtta catttgcatt gctaatagac ccttcctgaa tgtgtttgac attttacttg 432300
gctttgaaag gacttttatg ccgctgcttt ttcttcccta gtgctgcctt gggctaatta 432360
acctattccc ttactggctg ggcctactat atgcaaatgt tctcattttg cattctgaca 432420
catcactctt gcataaatat ccctcatgaa accctgtggg gttttattgg atcagtgctg 432480
caggagggcc agcagggggc gcatggactg gttctctctg agtaggtctc acgcatgagt 432540
tttccttgct cgttggtatg gaaatgtggg agcgtttggc attccctttc ttaagagtga 432600
gtcttgaaat ttaaagataa aagttcatta ttagaacttc tttttacaag ggaaggctgt 432660
acagaacaca gttatttgtc acttacaaaa accctaggtg ggcagggcgc agtggctcac 432720
gcctgtaatc ccagcacttt gggaggtaga ggctggtgga tcatttgagg tcaggagttc 432780
gagaccagcc tggccaacat ggtgaaactc cgcctctact aaaaatacaa aaattagcca 432840
ggcatggcgg cagccgccta taatcccagc tactcaggag gctgaggcag gagaatcgct 432900
tgaacccggg aggcggaggt tgcagtgagc cgagattggc acattgccct ccagcctggg 432960
cgacagagtg agactccatc tcaaaaaaaa aacacctggg ttgcgagagt aaataagtga 433020
cattactcct tcaacacttc atttcttcag cataagtgtt ttagggtttt tttaacctta 433080
tttttcattt ccgtcccagt ctttaagcgc ctctcttgtc atatgagaaa ttctattctt 433140
actgaaatgt cctttgatat cgagacacca aatttctaaa cctgcacctt cctagatatc 433200
tgatcaaaat cattaaggat tgagaacttt ctgttgtatc atttgtcatt tcattatgat 433260
gttcattgat gatgttggag caaaaccaat aagggccatt aaatcattgc cccttccaag 433320
ctggctgcag tggctcatgc ctgtaatccc agcaccggga ggccaagtgg gtggatcact 433380
gaggcctgtt caagaccagc ctggccaaca tggcaaaacc ccacctctac aaaaagtaca 433440
aaaattagcc gggtgtggtg gcgtgcacct gtagtcccag ctacctggga ggctgaggtg 433500
ggaggatcac ttgagcccag gaggcacagg ttgcagcaag ccgagatcac gccactgcac 433560
ttcagtctga gcaacgaagc aagacctttt caaaaaaaaa aaaaaaaaaa ggaaggaagg 433620
aaggaaaaaa atcattgccc cctctaaaaa atagttacaa agtagggggc agagtagaga 433680
aagggggtta tgtttcagta gggatttcag tgttgctcca acatggacaa ggattgaatg 433740
ctgaaggccg ctactttatt gtgtttgttt taaaatcgga tcattggcta cacacagtgg 433800
ctcatgcctg gaatcctagc actttgggag gccaaggaag gaggatttct tgaggccagg 433860
atttcaagac cagcctggtt aacatagcaa gaccccatct ctccaaagaa agaaagaaag 433920
aaagaaagaa aatcagatca ttgaaaagag ggtctggatg tgagatacca aaacccaagg 433980
gtgtggaatt cccaaagccc aatcccacag ctctcagaat cacagcatgt tgcactgtgc 434040
atacctacag ctgctacctg tggaagcaat cacatccgct gcttgctagc ctgggtcatg 434100
tcagttccac tgatatttgg cctcttgtct gttgggcatt ggtttgccca cacagcagca 434160
gtaactcaga cttcagtggt tagtaagaga ctgagatact tgaccataag aactggctcc 434220
agggtcacca tttgtatgtc caggtttgaa cacactgatc tgatttgtct gaaagagctg 434280
tcgtctctag tgttaatggc gagttgttac tttccaatga gaaaggggac ggtgtgaagg 434340
ggaacttcaa tgacaacttg aaaaggaaga gagagatgga caaaccaagc atgtaaccca 434400
ctgagaaaac attcagtgca ctagccctat ttttgtatgg tatttgggtt ttttaaccat 434460
aatcaaattc ggtttttaac agtctcactc cgtcatcata tgagtggctg tactgggaat 434520
tcttttgaaa cttgcagaga acaggattat ttctggcggc ctctgctgag ttggcgtgtg 434580
tgtgtgtgtt tgtgtgtgtg tgtattaggg agaggaaatc gtaggtccag tgtggaccca 434640
gagctaaggg gaatcttgga gagtagtggc tctggcagat gaggattcag aaatcgagtg 434700
caaggactgt tctggacttt cactgctaac ctgctttttc tcagtgcctg gctctgaggg 434760
cagggtccag ctggtgtcat gctctccaag ggcttcattt tatgttccag ccaggcaaag 434820
gagaggtgag aaatggaacc aacatttctg aaaaggaaat ttaagaactg catcatctgc 434880
ccttgaagaa gaaaaggaga aaaaaaaaca ggagagaggg tattgagaac atcttagggg 434940
agttgttaac tccattaaaa aatatatgtg ttacagtgtt cacttgccca gtgtcttcat 435000
aatcttcctt tataatgtgc agctgccacg gctagtgttt ttgtttttgt tgttgttgtt 435060
ttgtttcgtt tttggagaca gagtgtcgct ctgttgccca ggctggagta caatggtgca 435120
atctcggctc actgcaacct ctgcctcctg ggttcaagca attctcctgc ctcagcctct 435180
caagtagctg ggactacagc cgtgtgccag ctaatgttac accaggctaa atttgttttt 435240
tattttttat ttttggtaga gacggggttt caccatgtta gccaggatgg tcttaatctc 435300
ctgacctcgt gatctgcctg cctcggcctc ccaaagtgtt ggctagtgtt ttctctgctt 435360
cagtgcttgg ggtatgattg ggttatggga gttcacaccg agtccagggc ctagtcttaa 435420
tcttgccaaa gatgttcttt ccccggtgct catgttctga tgtcctttcc ctccttccct 435480
ttctcctccc tttccttttc cctttgtcac tgccctcttc cctttcccag catccagagc 435540
tgctgttggc ggattgtacc cacggggaga tgattcctca tgaagagcct ggatccccta 435600
cagaaatcaa atgtgacttt ccgtttatca gactaaaatc agagccatcc agacagtgaa 435660
acagtcaccg tggagggggg acggcgaaaa atgaaatcca accaagagcg gagcaacgaa 435720
tgcctgcctc ccaagaagcg cgagatcccc gccaccagcc ggtcctccga ggagaaggcc 435780
cctaccctgc ccagcgacaa ccaccgggtg gagggcacag catggctccc gggcaaccct 435840
ggtggccggg gccacggggg cgggaggcat gggccggcag ggacctcggt ggagcttggt 435900
ttacaacagg gaataggttt acacaaagca ttgtccacag ggctggacta ctccccgccc 435960
agcgctccca ggtctgtccc cgtggccacc acgctgcctg ccgcgtacgc caccccgcag 436020
ccagggaccc cggtgtcccc cgtgcagtac gctcacctgc cgcacacctt ccagttcatt 436080
gggtcctccc aatacagtgg aacctatgcc agcttcatcc catcacagct gatcccccca 436140
accgccaacc ccgtcaccag tgcagtggcc tcggccgcag gggccaccac tccatcccag 436200
cgctcccagc tggaggccta ttccactctg ctggccaaca tgggcagtct gagccagacg 436260
ccgggacaca aggctgagca gcagcagcag cagcagcagc agcagcagca gcagcatcag 436320
catcagcagc agcagcagca gcagcagcag cagcagcagc agcagcacct cagcagggct 436380
ccggggctca tcaccccggg gtccccccca ccagcccagc agaaccagta cgtccacatt 436440
tccagttctc cgcagaacac cggccgcacc gcctctcctc cggccatccc cgtccacctc 436500
cacccccacc agacgatgat cccacacacg ctcaccctgg ggcccccctc ccaggtcgtc 436560
atgcaatacg ccgactccgg cagccacttt gtccctcggg aggccaccaa gaaagctgag 436620
agcagccggc tgcagcaggc catccaggcc aaggaggtcc tgaacggtga gatggagaag 436680
agccggcggt acggggcccc gtcctcagcc gacctgggcc tgggcaaggc aggcggcaag 436740
tcggttcctc acccgtacga gtccaggcac gtggtggtcc acccgagccc ctcagactac 436800
agcagtcgtg atccttcggg ggtccgggcc tctgtgatgg tcctgcccaa cagcaacacg 436860
cccgcagctg acctggaggt gcaacaggcc actcatcgtg aagcctcccc ttctaccctc 436920
aacgacaaaa gtggcctgca tttagggaag cctggccacc ggtcctacgc gctctcaccc 436980
cacacggtca ttcagaccac acacagtgct tcagagccac tcccggtggg actgccagcc 437040
acggccttct acgcagggac tcaaccccct gtcatcggct acctgagcgg ccagcagcaa 437100
gcaatcacct acgccggcag cctgccccag cacctggtga tccccggcac acagcccctg 437160
ctcatcccgg tcggcagcac tgacatggaa gcgtcggggg cagccccggc catagtcacg 437220
tcatcccccc agtttgctgc agtgcctcac acgttcgtca ccaccgccct tcccaagagc 437280
gagaacttca accctgaggc cctggtcacc caggccgcct acccagccat ggtgcaggcc 437340
cagatccacc tgcctgtggt gcagtccgtg gcctccccgg cggcggctcc ccctacgctg 437400
cctccctact tcatgaaagg ctccatcatc cagttggcca acggggagct aaagaaggtg 437460
gaagacttaa aaacagaaga tttcatccag agtgcagaga taagcaacga cctgaagatc 437520
gactccagca ccgtagagag gattgaagac agccatagcc cgggcgtggc cgtgatacag 437580
ttcgccgtcg gggagcaccg agcccaggta acgttagcca gggtggcaca gggatgggac 437640
accacaccgt gatgccatca tcatctcctg gcaagacgaa ttgcttctat gaggcaggat 437700
taagggttct cgggtacacc tagaccttag actcggcctt tcccaactgc gttctctaga 437760
aaaaataagc cccatttccc cgtgatctct gctgtgtgta atgaattaac ctccatgcat 437820
ggagagtggg gctagttatg gagtccttga gacaatccag aaactcacca ctctagttat 437880
tttttgaatt ctgtgattaa gatgaggaac cctgattagg aaacgctgct ggacttcagg 437940
tccttctagt ggtcattcgg cactttttct taccaggaaa agacagagga tgccgttgga 438000
gtgaggggat tagatgctaa agcaatcata tcccattgca acatccatgt tttaaaatat 438060
gtcttattag ctgggtacag tggtatatgc cttcggtccc agctactcca gagactgagg 438120
caggaggatc acttgagccc aggagttcga ggctgtagtg agctatggct gaacctgtga 438180
ctatcactgc actcaagcct gggcaacata gcaaggcccg gtctccaaca tatatataat 438240
gtcttattat ttaggtatga taaggccaac agatagatca gcagacaact ctctttgacg 438300
agataatttt tatactctct gatcccaaga ggaaagggca ctctacacca agaggtgtag 438360
aacaccgtaa agtggggggc acctggggaa gccccaggtg ggtcaggagg tggagggagt 438420
gaggggaaat gtggcaaaca acagccttta ttgtggtttc atgggaggca gggtaaacgg 438480
gtttaggatt ggttagagtg gataattcca gtgtgctctg gggtgtaggg gctgtcctta 438540
gttgtctggc tgctggtgct ggggtgatca atacaggtgg aagggctggg cacagtggct 438600
cacacctgta atcccagcac tttgggaggc tgaggcgggt ggatcaccag aggtcaggag 438660
ttcgagaccg gcctggccaa catggtgaaa ccctgtctct actaaaaata caaaaattag 438720
ccgggcatgg tggtgtgtgc ctgtaatccc agctactcca gaggctgagg taggagaatt 438780
gcatgaaccc gggaggtggg gattgcagtg agccgagatc aggccactgc actccagcct 438840
tggacacaca gcaagactct gtctcagaca aaaaaaaaaa aacagatgga aggcagccct 438900
aagtgtgatg gaccaatata ggaggctgct ggggagtggg ctctggactg gttagtttgc 438960
atatgaaagt caggctccta ggaattagct ctggactggt tggtttgcat ataaaagtca 439020
ggcctctagg aattagctaa tcctaggaga gactatacct ctgggatcca caagacacta 439080
aaatatcaaa gcatcagaaa ataaaagcgt ggttaataca atctgagaag tcagggctgt 439140
cccaggtgac ctgctgggct tggggtaaag tcagctgtag ccaagatgag tcactggaag 439200
tatggttaac gctcttaatt tccacaggct ccttcaatct acccttttcc aggttcttag 439260
atcgattaca tgcatttatt ccacagccca tttctttcac tgcccaagtt gctgggagtc 439320
cagcaggttc agcctgcagc tgagagcttt cctggctatc gagcgtactt tctacaagtg 439380
tttccatcta ggatttgaaa acattcaaat gggacagagc ctccttccag cttgagttga 439440
aaatagtcat gaaatagctg ctatttggga cattcagata aaataaaaca agaaaaaaaa 439500
gataaactaa ttaatggttt gaattgtttt gggcattttt ttttttcatt tttgagacag 439560
tgtttcttgt ctcctaggct ggaatgcagt ggtgcaatca tagctcactg tggccttgac 439620
ctcctaggct ccagcgatcc tcccacccca acctccctag tagctaggac cacaggtgca 439680
taccaccatg cccagctaat ttaaaaataa aaaacatttt agtagagatg gggtcttgct 439740
gtgttgccta ggctggtctc aaactcctgg gctccaagca gtccttccac ctcggcctcc 439800
caaagccctg agattacaga cacgagtccc tatgtctggc ttttttgagc atttcttaaa 439860
tgcccaagtg aggaaaggac caaatcagtt ttccagaacc actcgtgaat gactggatat 439920
gggggcttgc acaaagccgg ggccctgcat tgccgagagc ttttagccct gaatactttt 439980
ctttgtatta tgagatgtca ctgtaggttt acagtctttg gaagggccca agaaagattt 440040
ccccaaagat cttatttaaa aaaaaaagaa aatcaggatt tttaaaataa atggcataat 440100
aatacagctc actacccctc tgtagtggct gttcacttcc tgcatgaatt aggggtgggt 440160
actaggagaa agaaaatgaa ctaccttgag caaagttgac tcttcacaga ccccaggtga 440220
cacatggaaa ataaacatga gtgaagagtc attgcttttc atggtactta gaatccttaa 440280
cacatttttg tgaacagagg caggtgtgaa aagaggtttt gtttagaaat gcgactggtt 440340
ccttgccggc cagcatcaac ttcagcttga gaatgaaggc agccacttca gctgtgggcc 440400
acacttccca ggcctggcag cctctgcaga aaccagactc ttctattttt tttttttttt 440460
tttttttttt tttttggaga cagagtcttg ctctgtcacc caggctggag tgcagagtgc 440520
agtggggtga tcttggctca ctgcaacatc tgcctcttgg ttcaagtgat tcttctgcct 440580
cagcctccca agtagccgag actacaggca cacgccatca ccccctgcta atttttgtat 440640
ttttagtaga gacagggttt caccatgttg gccaggctgg tctcgaactc ctgacctcag 440700
gtgattcacc cgcctcagcc tcctaaagct gggattgtag gcgtgagcca ctgcgcccag 440760
ccccttacag ccctcttctg ttcttgggga ggaagatcta ggtgtgtttt tccctactcc 440820
aaactttgca aaattaatga ttaaatgaaa gagaaattgg cttccctgtg aagtcagagc 440880
cctgttctca tgttttttcc catagtgaga tcactaaatc tctctactga cagccagggt 440940
gcagacgagc aggtagaagt gttgtcaggg cctgttggca ggtctgtgag gttggccccc 441000
gcgtggctat gctgcatgcc gggaagggct tcctcaaaga aaggcaagtg tgctgagacc 441060
tgctgaaaag gcagctaggg cttcacgctg tagaaacaaa agtgcaaggc ctgacgcaac 441120
caatgatttg tcactttacc gaggagccta tcagaaatcg gctgacatca tcacagctaa 441180
aatactccac cagctgtgtt tgccacaagt gacaggttca gagtcagtgg agactcagac 441240
agagagcatg agagggggag atgggaggga gagagagaac tcatatctgg acttaattga 441300
ggttccaaag gctacatcct tctcccctct gcagtgcctt cctgaggggt tttctcccct 441360
agcctgaaga atcttcctgg tcttctcaac tggttaggca ctgctgacac tgcacccaca 441420
gagaaattca gaaatgtgca aattgttgag cttaataagc aaaatcacaa atttgattgg 441480
ggaagttgtg gaagaagaga tggttttctc caaaacagat ggcattgtga ctctaggcag 441540
aaatcctgca tgaacagact cttgaggatg cctgaactca taagaccccc ccaacatcac 441600
acccccaggg aaagcagtgt gatatagtat ggtggtgaca gacccagggg tgcggatttg 441660
ggtctctggc aggacaagtt acttcacctc tctgagctgc agcactctcc tctctaaacc 441720
aggcaaatga gttttgtttt tctgtgggtt tttgtgttcg tttgtttgct tgttttgaga 441780
cagggtcttg ccctgtcacc caggctgaag tgcagtgatg ggatcattgg ctcactgcag 441840
cctcaacctc ctggactcaa ttgatcctcc cacctcagcc tccccagtag ctgggactat 441900
gggtgtgtac cactacaccc agctaatttt ctgtgttttt ttgtagagac agggttttgc 441960
tatcttgccc gtgctggtct ggaactcctg ggctcaagcg atccacccac ctcggtctcc 442020
caaaatgctg ggattatagg cgtgagccac ggcgcccggc cacgtatgat tcttcatagg 442080
agataatctc ttgagagggt tccgtttttt aatgcttcac ttttatactt tccagaacag 442140
cacagccctt gtaaaaattt attagcgtcg gttaacaaaa aaccaagaag agcattaaga 442200
tgaacatgta ctgacctcat gctaagcggc acacagacct catgggaact aaagccatgg 442260
catataaaac tgaggggtgt ttagtttggg gatgattttt aaggggctga attcctcatt 442320
aagactgtgg aaagatgccc ccagcattgt cccagctgac gctccagacg aggcaatgta 442380
ggagaaaaat gcttttccgt gtttgtcact atccctgtgg cattgccctg cccagtacag 442440
cttttctcca ctcgagcaaa gcgtctatgc atcccccagg cccccaccta ggtgctgtgg 442500
gaggaaaggg gaatgccagg tgttgtccat tgttactgcg tgcaccaaag gaagcctcct 442560
tcctcttcag tggagggtga tagcacgttc cccaccctgg aagagagttg ctgctttgcc 442620
atgccttgat tctggttgag agtcccaaag gatgacagaa tcacttccct tgggcctcac 442680
tgccaaatat aatccactta atatcctcca agtttgaggc cataagtctg tggcgcatcc 442740
agatgcgacc cccgaggcga tagcatcaac gtgggagcca atgcaactca aaagaaggat 442800
ggggcttcgc acctcctcct tgggtaggaa gtaggttagc tgcttggaaa atgcaggaac 442860
tggcactgaa gagatctgag tctgaacata tccctcaccc gtcagtagca ctgggacctt 442920
gtgcaatgtt agttttccct tccctgcttc aacttagatg gctcgggccc tgagaaagtg 442980
attcacagct gaaaaataaa tcaaaggcct cgtgttctaa aaagagttta tggaaggaga 443040
ggcagctgat gaaagtctag aaagaaggct gaacttttcc aatgagcaca ataagccatt 443100
tttaccctgc ctgtaatcct cggggtggaa tcccgcgagt ggccgaggcg agcacccttc 443160
ccgccgttcc tgtttctaag gctaaatgat gtcatgccag cctgcgtgag catatcaatc 443220
tgtatttctg agtatgaact ggatttgagg ggtgcattgg tgctccagcc ctccagatca 443280
gtaagacaac caatgcagaa acaagggctc ccaggctcct cttctgcaag aggctgttag 443340
tgacgtgccc gctgggacag ccctgcccag gatggcccca gctggggagc ctttggcttc 443400
catctggcgg cgttctatat tatcccatcc ttctgtctca cccttcctag gttcagcttc 443460
tctgaagagt acacagcatt tgctcagtgg agttgtaaaa tgtattggta aagtgctctg 443520
ggttgacacg ttcctttgct tctttcctaa atgccaggct ctgtgttatt agggccgtct 443580
gtcgcttccc agcgcctccc gaggtgactg cttccctgac tcggtggctg cttaatattc 443640
agtgccattt cctcctcccg actgtcctgg cgtgggtgtg agtgtgcctg tgtgtgtgct 443700
cgtacagcag ttgttatcat gatgtactta ctggctgtct accgatggct ttcctttcat 443760
tctactattt tttggttgac ttctgtgagc tgtgagtcat cggtggtaac attatgcatt 443820
gaatggatta gctggtacct aaaaatagcc gaggccctca tgcaggcggc acatgagcct 443880
gtagagtcag tccctttgca gccaaggcag acccacttgc caacattgaa catgccgagc 443940
ttggtggcga tgaatcctaa tgtatcaaaa aatagatagt tggtgactgc cctgtgtgca 444000
gagcccagcc ctggatttgt gccgcagttg ttggtaatac acacttcctg tctgttctgg 444060
tgctggaaag gctccaacag agaaactatg tcaaaccaca tttttgtttg tgggtctttg 444120
tacctctcta aaaaaaaaaa aaaaggagaa aaatgctctc ctttaaactg tatgtgctat 444180
atgtgccccc aactgggtca tcttatatgt tttgattctc tcagactgtt gttgtttata 444240
gcatttagaa aaaaattaaa gactattgtt taaagcagtt ttaggtgtac agcaagtaga 444300
gagaggtctc acacacctaa cagttttccc tgttattaaa atcttgcatt ggtgtgatag 444360
attggttaca actgatgagc cagtaccgat accttatttt taactaaagt ccatagttta 444420
tactacagtt cactctgtgt tgtacatgct gtttttgatg aatttatgat gtcatgtatc 444480
cagcattaca ttattataca gaacagctgt accaccctaa aaatccctta tgcatcaact 444540
atttgtcccc cacaccccac ctgaaactcc tggcacccac tgatcatttt actctctcca 444600
tagttttgcc tgttccagaa tgccatgcag ttggaatcat ccggtatgtc gccttttcac 444660
attggcgtct ctcacttagc gatatgcatt tcaggttctt ccatgtcttc ttgttgctct 444720
gatagctcat ttctttttag cactgaatat tatgttgttc tttaaggcac attttttttt 444780
tttgagatag ggtcttgctc tgttgcccag gctggagtgc agtgacacca taatagctca 444840
ctgcagcttt gacctcctag gctcaagcaa tcctcccact tcagcctccc taggaacagg 444900
gaccacaagt acacaccacc acgcccagct aatttttcta tttttttgta gagacggggt 444960
cttgccatgt tgcccaggct gctcttgaac tcctgagctc atgtgatcct cccgcctcag 445020
gcccccaaag tgctgggatt acagggatga gccacccttc cctgcctaag gcacacattt 445080
taaggcccca gaaaaggaag gcaagtgagc tagaacctgt gtgcctaagg gcttccgtgt 445140
cacagctgct gtggtcactc actgggcagt gtccttcctg gccatccctg agcctcccca 445200
cagggccttc ccacaaggga gctctgtgag ccacgctacc atgtgtaaga aaaacccagc 445260
ttttaatgtg ggatttgtgt taggaggcgt cccggtgcta gggtgtgggt ttactgaaca 445320
accctgaaac acttccacca aggactgagt caggctttgc gtgaacatga ttcagtgttt 445380
taaatagaac actcacagag attcttacac tcagccaaag cgttttgact gtttttatta 445440
atgattttta aacattgcag taaatgggtc tctcgcttac ccccttcatc tttgagacgg 445500
ggttttctga tttttttcat gctgagaacg taaccatgca gacttagcct tccaggaaag 445560
cagaccggcc tttctctaca ggtaaaacaa gactgagaat ttcacttgca gacaaagtta 445620
agaatgccca atttaataat ttcgccaaaa aacaagacat acttactgaa acctagctta 445680
tgagagaatt cattgctccc agcaacaggc gaaatttgta tgtctgggat agtgtcatga 445740
aaaaatgttt tgtaaaacag atgcccttcg caatttgtga aaacagggac tcttgtgaag 445800
gaaatgggag acatatttaa acaacagacg ttttgttttc tttctatctt gtttttggtg 445860
atatgtacat atgtgtgtat atagacatag caccaatcta agattgaaat atacaatcaa 445920
acagcataaa tatgcgtgta tgtgcatagt gtttagatat agtagttatt gactaagtgg 445980
tgaaaggaat tttattgaat tttcatacag aggagctaaa atttttctta aaagccagtc 446040
attagtcaga ttaggaaggt gacatttaaa aaataattat gagcccagaa gtgagtcggt 446100
gttgtctccc tgtctaggtt cgtccatcca aaatgggagt tggaggtgac agttctagag 446160
gagtcgattt agggggatgg atggaggaag gggtaggcag atctcttata accacactga 446220
tgagcacatg ggcttgctgg cagcagtggg aggagggagg gaaagagtgg aggagggtgg 446280
gaggcggtcc acccccaaaa gcaagaggtg ctggcgacag ggcatccaga gatgaaagac 446340
agagggccct caagcttaca aaagtataaa ggccatccct gggcgcggtg gctcacacct 446400
gtaatcccag cactttggga ggccgaggtg ggtggatcat ctgaggtcaa gagttcaaga 446460
ccagcctgac taacatggtg aaaacccgtc tctactaaat acaaaaaaat tagcctggtg 446520
tggtggcagg cgcctataat cccagctact tgggaggctg aggcaggaga attgcttgaa 446580
cctgggaggc agaggttacc gtgaatcaag atggcaccac tacactctag ccttggcgac 446640
agagtgagac tctgtctcaa aaaaaaagaa agaaagaaag aaagaaaagt tataaaggct 446700
attctactta ctgcttaggg tgtttgaaac aggatatatt tactggatga aaaaatgggc 446760
tatattgagc tgtctggcgt tatgtaacgt gctttggtta tctgtggtac tgctcccatg 446820
agtttatttt cattgggatt taatcagaaa ccattctgga aaatgtgtgg aaccccagca 446880
agatcataaa atgacttaat gattactaac acagctgcaa gaacgagagt ggagagaaaa 446940
taactgaagt gtgattcaat aaaatcatga cgacctcagc atctgacaag gtgaggtggc 447000
tatggctccg ctgagaaagc tgcctgttag gcggtaaagc cacaccctgg agaaagcact 447060
gctcctctcc ctgggggagg tcacagccca ctttagttct ggctggttaa aaaaaaaaaa 447120
aaaaaaaaaa aaaaagacag gcagtctctc tattgccccc tgttgtccac ttgtaccatt 447180
gcaatgtttt tccatacaga aggcaaacag aactattctt tcagtttttt ttttgttttg 447240
tttttgtttt ttttaagacg gagtcttgca ctgtcacctg ggctggggtg caatggcgtg 447300
atcttggctc actgcaacct ccgcctccca ggttcaagca attctcctgc ttcagccttc 447360
agagtagctg agattacagg cacctgctcc cacgcctggc taattttttt gtatttttag 447420
tagagacagg gtttcaccat gttggtcagg ctggtcttga actcctgacc tcatgatcag 447480
cccgcctctg cctcccaaag tggtgggatt acaggtgtga gccaccatgc ccggcctctt 447540
ctttcagatt ttaactgagc acctattact tgctaggaag tcttttagac tctggagata 447600
gaacactgag tttggggaaa gaggcaaaac agacaaatat acaagtaaat aaaaaagaat 447660
gcataagaag ataaccagtc ccttttggca ccagggactg gtttcatgga agaagatttt 447720
ttggcaggat gggaagaggg agggggatgg ttttgggatg aaactgttcc acctcagatc 447780
atcaggcatt agttagattc tcataaggag tgcacaacct ggattccttg catgcgcagt 447840
ttacaatagg gttcacgctc ctatgagaat ctaatgcttg cgactgatct gacaggaggc 447900
ggagctcagt ctggaatggt tgctcacctc cagctgtgca gcccagtacc taacaggcca 447960
tggactgcta ctggtctgtt gcctgggggt tggggatccc tggtataaag aggagaaggg 448020
gccaggctag gtggctcatg cttgtaatct cagcactttg ggaggctgag gcaagagggc 448080
acttgaggcc aggagttttg aaaccagcca ggccaacata gcaaggctcc atctctacat 448140
aatgatcatc attatcttca ccaacaaaac attagctgga catggtggtg catgcatgtg 448200
gtcccaacta ctcaggcggc tgaggcagga agatatcttg agcccacgag gtcaaggctg 448260
cagtgagcca tgatcatgct actgtactcc agcctgggca acagaacaag accctatctc 448320
aaaataaaaa aaggaagcta tggaaactag agggttgtta ttttaaatag aactgtcagg 448380
ggagttctct ctgaaaagga cagtgggtgg caacagtacg tgaggcaaaa aagattccaa 448440
atgaatggag agagtagcag gtgcccagac ggaaggcgca agaggggtta aagaaccagc 448500
aaggagacca ctgttgctac agtgtaggga gtaaggggca catgcagacc acatcaggct 448560
tgcatgtggt gaccgagcga gtgagatgca gcttggccag gacaaaggtg gtggaggtag 448620
taaaaaaata gtatcattct aggtgtattt ggaaaaggaa cccatacagt ttgcttataa 448680
ttgggatgtt tgtgatgtaa gagaaagagc ggaagaaagt atgattccaa ggtgcttgat 448740
tgaacagccg gaagaatggg ataccattta tggagatggg gaagaacatg ggatggccac 448800
cgggcagggg cacatcggga ggtctggtgt gttttaggtc actttaagtt tgagttgccc 448860
attcgacatc tgagtggacg tcatcggata gtgtggtcac tggtgtccaa atgtacccgt 448920
tttgcgtgta tgttctgtct cctggtggga ggcaagaaac taggtcttaa ccaatagata 448980
ctcttctaag gttcctaaca cttagcaggt gctcggtgta tacttgttga acttttatta 449040
aaactggaaa gcctgaaatg tatcattagg aaccctcaat aatattttga ggccgggcac 449100
ggtggctcac acctgtaatc ccagcacttt aggaggccaa ggcaggcaga tcacttgagg 449160
tcaggagttc aagaccagcc tggccaacat ggtaaaaccc cgtctctact aaacatacaa 449220
aaattagcca ggtgtggtgg cttatgcctc ccagctactc gggaggctga ggcaggagaa 449280
tcgcttgaac ccaggaggtg gagtttgcag tgagccgaga tagtgccact acattccagc 449340
ctgggcaaca gagcaagact ccatctcaaa aaaaaaaata ataataataa caatattttg 449400
aagctatcag catcatagag aatacccata tgggttttaa attcaaggaa ttcacagact 449460
tattgttcca gttgaagatg acatcatcct acaaaatcac accgtctctg tttcacatcc 449520
aaaccagtcc ccgctggcat tgacagcatg ttttgagatg gagaaggctc ctctccaagg 449580
gaatttcaag caacagattt gatgatatat attctcactg agaaacccct cagtgagatt 449640
tcttcattaa cggttaatga tcagttaacc tttaagaatg tttatatcct tatgacaaac 449700
ctaattataa aataaagata gatttgctat gaatgcttga gtgtacctat ttgagatgtg 449760
tgcaacaaga ttttaacttt caccaaagaa gggaaaaaaa ccttatttta cttctcatac 449820
attcagaccc caagggggaa aaagtacatt gtctaggtag ttcacactaa ttagtgagga 449880
gaaaactagc attgggctgg caagctatcc gatctgtgcc tacaatgatc agattatctg 449940
aataatcttc cgctcccacc tcagctttca tggacccagc tgatatctgg tcgtggcatc 450000
ttttcgcagg gtgacacagc tcctttggta ggaagcaaag gcagaattta ggcaaaaaga 450060
aacaaagaga agcctttgaa gtgattaaag aagaatctcc caagcctatc taggttaaca 450120
taaatttcat taacaggcca ggtgggcgcg gtgactcact tctgtaatcc tagcattttg 450180
ggaggctgtg gcgggcagat cgcctgagat caggagttca agactagctt ggccaacatg 450240
gtgaatgaaa ccccgtgtct actaaaaata taaaaaatta gccaggggtg gtggtgggca 450300
cctgtaatcc ctgctacttg ggaggctgag gcaggagaat cgctcgaatc caggaggcag 450360
agattgcagt gagctgagat ggtgccactg cactccaacc tgggtgacag agcgagactc 450420
tgtctcaaaa aaaaaaaaaa aattccatta acgtcatctt gttttagtac gcatctcaaa 450480
tattctctct ctccatcact tttctctcgt gaatttttcg gcaggctgtt ctagctatgg 450540
ttcacaccac agcatttaat tctaaggcct gtctttggag atttggagtt tggtttggtt 450600
tggtttggtt tttagagaca gagtcttgct ctggcacaca ggctggagtg gtgcagtagc 450660
tcgagtgacc ctcgcacctc tgtaactgaa cttaggtttg gctgctcacc actcaaaagc 450720
caaatacgag agatgaggtt ggtgagagga aaagcaggtt tattgggaaa gccagagaaa 450780
ttgagaagat gatgagctag ccttctaaag taccatctcc aggccaggca tggtagctca 450840
catctgtaat cccagcactt tgggatgcca aggcaggcgg atcacctaag gtcaggagtt 450900
tgagaccagc ctgacccaca atggccaaac accatctcta ctaaaaaata caaaaattag 450960
ccaggtgtgg tggcacatgc ctgtagtccc agctactcag gaggctgaga caggagaata 451020
gcttgaacct aggaagcaga ggttgcagtg agccgagatt gtaccactgc actccagcct 451080
gggcaacaga gaatccatct caagaaataa taattttgta aaaattaagt aaaatctcca 451140
attttttagg ctggttggag ggtttttatg ggaggggggt atggggggag acgaaggggt 451200
tagtatcgag gagactgagg accatagaca tttgggcacc agtgagggtt caagaaggtt 451260
gagaacttct ttgtccttgg tcaggtcata atgctccttc agtctttagt atttttaata 451320
gagggtttca ccatattggc cagactggtc tctaactcct gacctcaggt gatccgcccg 451380
cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgtgcccag ccactcctat 451440
cagtctttaa caatatatag ttagttgttt atatacttcc cctttaatcc cagagttagt 451500
ttctaaaagt acatgattgt tgtttgtgta tattatctcg gtgccataaa attatcctag 451560
cctacgtgca ggaaagggta aaacccttta aacaaaaatg gagttagtta tgttcgttct 451620
tttgctattt cacaattgta cctcagcctc ccaaagtgct gggattacaa gagtggtgtc 451680
tttggagttt tgagatgcgg aaataatgaa aggctttcaa aatgtccaat aacattatga 451740
agtctttaga gggaaacacg tgtatctgta tcctgacttt tgcactaatc aattatagta 451800
cctgttataa agggcttgta gacatttctt aatgagtcta cagatacttg gtaacgtgga 451860
aatcctcaga taagtttacc tatgagaaca cagtagatgt tattttcaga aaattaaata 451920
ttgcctgccc tgtgaagtgt gtataatgtg gctcacacac caagggcctc tccatgggta 451980
ggtgtccggc catctgccag caaggagaca gggagttatc cgggaacacg cagaaccaga 452040
aaagaggctg acatgtttgg aactaaggct tctggtcttc tgaatgtcac attacctctg 452100
cctggtgttg ggcaagaata agcaaaccgc aactctggta gagagtctta cgagacagat 452160
gttaacacct gagagtttta tttttatgac ttggatttgc agcaaaacaa tctccacttg 452220
atgtgggatt ggtttccttc tgttcagttt atgttgttaa tgactctaag aggtttgcaa 452280
gaggatctat ggagccagtt ccagattggt cctcctactt agaatacagt gggtatcccc 452340
atctgataca gtcacttgta agtatatttg tctatgtata tatgcacata tatgtttctg 452400
tgtgtgatgt aaatgtagtt ttgaaaccaa atagtgtcac acacttgtac agggtaacta 452460
gaattgtatg agtggctata aggcaaacac tgcatcacaa ttatctgtac catggaacaa 452520
gcccatgagc tcatgccttt ggatcctact tatttcagtc aatattcacc actgttgggg 452580
ggtagcagga atgcttagtt catctctttt ggtggcattg taatgtcttt gctcacaagg 452640
gtagaggtca ggaggcacag aaaaaagaaa atgggtttgg gggccaatga ctgggataaa 452700
atcctaaacc cattagctaa tagctatgac attaggcaag tgacttaatc tctctgtgac 452760
tattcgtaaa atttacaaaa ttggaagagc aatactattc catactaata ctattatgaa 452820
cattaaacaa aatacttttt gtaaagtttg tacctgagag cttgacagag agtaggcact 452880
caaaaacttt tagcttgctt cacattataa aaatagccca gaacaatgaa actttccccc 452940
agtaatacac acaggagaag gggttcatgc ttacaagctg ccatatgaat gtactcaagt 453000
tgtctcttct aaaaatatgc cttgtatgga tccagtaaag tctgtcattc tagaaatgta 453060
tcagaactag atcaatcaga gttaacaaag gaaacaaaga agatgaagta gaaaagcaac 453120
aatctgtgga aatctactac ttttaaagtt tttttggtac ttcaattatg catgtgtgtt 453180
tttgtgtgtc tgaatgtgta taaaatccaa tggaggcctg acacggtggc tcacgcctgt 453240
aatcccagca ctttgggaga ctgaggcggg tggatcatga ggtcaggata tcgagaccat 453300
cctggccaac atggtgaagc ccccactcta ctaaaaatac aaaaagtagc tgggcgtggt 453360
ggtggtggtg catacctgta gtcccagcta cttgggagtc tgaggcagga gactcgcttg 453420
aacccgggag gcggagattg cagtgagccg agatcgcgcc actgcactcc agcctgggcg 453480
acagagcaag actccctctc acaaaaagaa aaaaagaatc caacaatatt ttaaatattg 453540
ttacatatag ccaatattca ttcagattca ccatgtatct accattttca ttcctcttca 453600
ttcctccctg tacaaacttc aatctagatt tgttttttct ctacctaaag aatacctttt 453660
agtattttct ataatgcaga tctgttgatg gtgaattctt ttaattactg tttgtctgaa 453720
catgtctcta ttttgccttc attctggaag gatctttttg ctccatatag aattcgccat 453780
tgacaattct ttttctttag cactgtaaag atattccatt gtctccattg tctactggct 453840
tccattattt ttgttgagat gtaaactgtg agttccattg ttgcttattt ggagataata 453900
tgtattttgt tctagaggct tttttttttt aatggagttt ctctattgtc gcccagtcta 453960
gagtgtgatg gaatgatctt ggctcactgc aacgatcttg gctcactgca acgatcttgg 454020
ctcactgcaa cctccgcctc ccgggttcaa gtgattctcc tgcctcagcc ccccgagtag 454080
ctgggattac aggttcctgc caccatgccc agctaatttt tgcattttta gtagagatgg 454140
ggtttcacca tgttggccag actggtctca aactcctgac ctcaggtaat ccacccacct 454200
cggcctccca aagtgctggg attacaggca ggagccacca cacccagcct gttctagagg 454260
cttttaacga tattttttcc tgtttagttt acaagatgtc tttgatttat agcagtttaa 454320
ttctcatctg cctcagtgag gatttctttt tgtttatttt tcctgtttgg ggctaggcct 454380
tcttgaaact gtcttattat ccttcttcag tttgggaaaa ttcttagcca ttacctcctc 454440
aagtattaac ttctgcccta ttatctccct ctcttcctcc tcctaggatt caaattatgt 454500
gtctgttagc ccctctcaat gtatcctatg tgtctcttac cctctcctcc atattgacca 454560
tctttttgtc tctatgttca ctctgtggag tctcttctaa agctctaatt agagaatcca 454620
gttcctgaat tctttcttaa tccatgtcta ttcaactgga aagctcattg cattcttgat 454680
ttcagtggtg tatattttaa ttctacaatt ctcatagacc ttttttaatt aattaattat 454740
tattattatt attatttatt tttttttttt ttagagacag agtctcactc tgttgtccag 454800
gctggagtgc agtcttgtga tcatagctca ctgcaacctc taactcctgg gctcaagatc 454860
ctcctgcctc agcctcctga gtagttggga ctacaggcac gcatcaccac actaggctat 454920
ttttttttaa atttctgtag aaacggggtc tcattttgtt gcccagactg gtctgaaact 454980
cctggcctca agtgatcctc cctgtctcag cctcccaaag tactgagatt acaggcatga 455040
gccaccatgc ctggcttcat ggatctttta aaaacagatt ctagtttcct atcaaaattc 455100
tcaagctgtc tttaatcttc ttaattattg taagcatagt ctttgtaaag tctatatgta 455160
tgactctata tgagaagccc tggtgcatcc ttttttaaga tctgatattt tgctagtgct 455220
tatacaagct atctggtctc ctcatgacca ccacccccct tttttaaatt gaatgctttt 455280
atttgcaaaa ttgtgaaagt aattcaagac cttaatccag ttttagggac tcagatgagt 455340
caatctgagc ttcagacctt gaaaggcctg ttggcttgtg gttcactgtc tcctctaagg 455400
gacagtgctt tggggtcaca actcaaaaga atggggctca ccagagaaca ccctcccttg 455460
gtgtatcctg aactccatta cctgttccct atgctcttaa cactatcaaa agcccacttg 455520
gtttcccaac tgctccactt tggaatgttc aagtgccttc aggagaaaac aggcccccaa 455580
caccagcttc acctctctgg gccatcatct tttcctgatc caacccagga agtgtgtgtg 455640
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgac ggagtttcac tctgtcgccc 455700
aggctggagt gaagtggcat gatctcggtt cactgcagcc tccgcctccc gggttcaagc 455760
gattctcttg cctcagcctc ctgagtagct gggattatag gcgcctgcca ccacacctgg 455820
ctaatttttg tatttttagt agggacaggg tttcaccatg ctggccaggc tggtctcaga 455880
gtaaagtggc acgatcttgg ctcactgcaa ccttcgtccc ccggactcaa acgattctcc 455940
tgcctcagcc tcctgagtag ctgggattat aggggcccac caccacacct ggctaagttt 456000
tgtattttta gtagagatgg ggttttgcca tggtagccag gctggtctca aactcctgac 456060
ctcaggtgat ccacgcgcct tggcctccca aagtgctggg attacaggca tgagccaccg 456120
cgcctggcct ttttactatc ttatttgctg tccagtacta taagaaaaaa agtttaaaca 456180
ttttgtccag agtttttaaa tttatttgtt tgcttatatt tttgttcaga gtttttagtt 456240
gtcctcagaa ggagggttgg tccaaattac ctagtctact acatctagaa aggacattgg 456300
aaattgactt tttttttttt tttttgagac ggagtctcac tctgtggccc aggctggatc 456360
gcccagtggc acgatctcgg ctcgctgcaa catctgcctc ctgggttcaa gtgattctag 456420
tgtttcagcc tcccaagtag ctgggattac aggtgcccgc caccacgcat ggctaatttt 456480
ttttttttat ttttagtgga gacggggttt ccccatgttg gccaggctgg tcttgaactc 456540
ctgacctcaa atgatccacc caccttggtg tcccaaagtg ctgggattac aggcatgagc 456600
cactgtgccc agccaccaag catcctttta ggggctgggg actcagtgat aaacacactg 456660
tgcctgcttc ttggaactca cagtctcact ctgatccatg tttagtcctg tcctgtatga 456720
taatagcagt tgtccattga gctcataaaa tctaagaccg cgctgggctt gtgagccacc 456780
tgcagagcct agcttggtgc tgaaagctaa gtgggtgctc tgtcattact ggggttcgat 456840
tgactggttc taacagagac cagctataga gctaacactt gatggaatat tttgaatatt 456900
gatgaccttt tcactggctt ctgcctatgg caagtagagg tacaacccaa agagaagagc 456960
ctcatttata gtgtgtggct gggggagagg gaggtttgca aactgagtca ttttccccca 457020
ttcagcctgt gtgtgtctgt gtgagttcat acctgtgtgt gtgcataaaa tcaaacaaga 457080
ataaaatgtt ttcatttgtt cccttccttc ttcctctctc tgtctctccc tgtttccaca 457140
ggtcagcgtt gaagttttgg tagagtatcc tttttttgtg tttggacagg gctggtcatc 457200
ctgctgtccg gagagaacca gccagctctt tgatttgccg tgttccaaac tctcagttgg 457260
ggatgtctgc atctcgctta ccctcaagaa cctgaagaac ggctctgtta aaaagggcca 457320
gcccgtggat cccgccagcg tcctgctgaa gcactcaaag gccgacggcc tggcgggcag 457380
cagacacagg tatgccgagc aggaaaacgg aatcaaccag gggagtgccc agatgctctc 457440
tgagaatggc gaactgaagt ttccagagaa aatgggattg cctgcagcgc ccttcctcac 457500
caaaatagaa cccagcaagc ccgcggcaac gaggaagagg aggtggtcgg cgccagagag 457560
ccgcaaactg gagaagtcag aagacgaacc acctttgact cttcctaagc cttctctaat 457620
tcctcaggag gttaagattt gcattgaagg ccggtctaat gtaggcaagt agaggcagcg 457680
tgggggaaag gaaacgtggc tctcccttat catttgtatc cagattactg tactgtaggc 457740
taaaataaca cagtatttac atgttatctt cttaatttta ggtttctgtt ctaaccttgt 457800
cattagagtt acagcaggtg tgtcgcagga gactggtgca tatgcttttt ccacgagtgt 457860
ctgtcagtga gcgggcggga ggaagggcac agcaggagcg gtcagggctc caggcatccc 457920
cggggaagaa aggaacgggg cttcacagtg cctgccttct ctagcggcac agaagcagcc 457980
gggggcgctg actcccgcta gtgtcaggag aaaagtcccg tgggaagggt cctgcagggg 458040
tgcagggttg cacgcatgtg ggggtgcaca ggcgctgtgg cggcgagtga gggtctcttt 458100
ttctctgcct ccctctgcct cactctcttg ctatcggcat gggccggggg ggttcagagc 458160
agtgtcctcc tggggttccc acgtgcaaaa tcaacatcag gaacccagct tcagggcatc 458220
gcggagacgc gtcagatggc agatttggaa agttaaccat ttaaaagaac atttttctct 458280
ccaacatatt ttacaataaa agcaactttt aattgtatag atatatattt ccccctatgg 458340
ggcctgactg cactgatata tatttttttt aaagagcaac tgccacatgc gggatttcat 458400
ttctgctttt tactagtgca gcgatgtcac cagggtgttg tggtggacag ggaagcccct 458460
gctgtcatgg ccccacatgg ggtaaggggg gttgggggtg ggggagaggg agagagcgaa 458520
cacccacgct ggtttctgtg cagtgttagg aaaaccaatc aggttattgc attgacttca 458580
ctcccaagag gtagatgcaa actgcccttc agtgagagca acagaagctc ttcacgttga 458640
gtttgcgaaa tctttttgtc tttgaactct agtactgttt atagttcatg actatggaca 458700
actcgggtgc cacttttttt ttttttcaga ttccagtgtg acatgaggaa ttagattttg 458760
aagatgagca tatattacta tctttaagca tttaaaaata ctgttcacac tttattacca 458820
agcatcttgg tctctcattc aacaagtact gtatctcact ttaaactctt tggggaaaaa 458880
acaaaaacaa aaaaaactaa gttgctttct ttttttcaac actgtaacta catttcagct 458940
ctgcagaatt gctgaagagc aagatattga aagtttcaat gtggtttaaa gggatgaatg 459000
tgaattatga actagtatgt gacaataaat gaccaccaag tactacctga cgggaggcac 459060
ttttcacttt gatgtctgag aatcagttca aggcatatgc agagttggca gagaaactga 459120
gagaaaaggg atggagaaga gaatactcat ttttgtccag tgtttttctt tttaagatga 459180
acttttaaag aaccttgcga tttgcacata ttgagtttat aacttgtgtg atattcctgc 459240
agtttttatc caataacatt gtgggaaagg tttgggggac tgaacgagca taaataaatg 459300
tagcaaaatt tctttctaac ctgcctaaac tctaggccat tttataaggt tatgttcctt 459360
tgaaaattca ttttggtctt tttaccacat ctgtcacaaa aagccaggtc ttagcgggct 459420
cttagaaact ctgagaattt tcttcagatt cattgagaga gttttccata aagacattta 459480
tatatgtgag caagattttt tttaaacaat tactttatta ttgttgttat taatgttatt 459540
ttcagaatgg cttttttttt tctattcaaa atcaaatcga gatttaatgt ttggtacaaa 459600
cccagaaagg gtatttcata gtttttaaac ctttcattcc cagagatccg aaatatcatt 459660
tgtgggtttt gaatgcatct ttaaagtgct ttaaaaaaaa gttttataag tagggagaaa 459720
tttttaaata ttcttacttg gatggctgca actaaactga acaaatacct gacttttctt 459780
ttaccccatt gaaaatagta ctttcttcgt ttcacaaatt aaaaaaaaaa tctggtatca 459840
acccacattt tggctgtcta gtattcattt acatttaggg ttcaccagga ctaatgattt 459900
ttataaaccg ttttctgggg tgtaccaaaa acatttgaat aggtttagaa tagctagaat 459960
agttccttga ctttcctcga atttcattac cctctcagca tgcttgcaga gagctgggtg 460020
ggctcattct tgcagtcata ctgcttattt agtgctgtat tttttaaacg tttctgttca 460080
gagaacttgc ttaatcttcc atatattctg ctcagggcac ttgcaattat taggttttgt 460140
ttttcttttt gttttttagc ctttgatggt aagaggaata cgggctgcca catagacttt 460200
gttctcatta atatcactat ttacaactca tgtggactca gaaaaacaca caccaccttt 460260
tggcttactt cgagtattga attgactgga tccactaaac caacactaag atgggaaaac 460320
acacatggtt tggagcaata ggaacatcat cataattttt gtggttctat ttcaggtata 460380
ggaattataa aataattggt tctttctaaa cacttgtccc atttcattct cttgcttttt 460440
tagcatgtgc aatactttct gtgccaatag agtctgacca gtgtgctata tagttaaagc 460500
tcattccctt ttggcttttt ccttgtttgg ttgatcttcc ccattctggc cagagcaggg 460560
ctggagggaa ggagccagga gggagagagc ctcccacctt tcccctgctg cggatgctga 460620
gtgctggggc ggggagcctt caggagcccc gtgcgtctgc cgccacgttg cagaaagagc 460680
cagccaagga gacccggggg aggaaccgca gtgtcccctg tcaccacacg gaatagtgaa 460740
tgtggagtgt ggagaggaag gaggcagatt catttctaag acgcactctg gagccatgta 460800
gcctggagtc aacccatttt ccacggtctt ttctgcaagt gggcaggccc ctcctcgggg 460860
tctgtgtcct tgagacttgg agccctgcct ctgagcctgg acgggaagtg tggcctgttg 460920
tgtgtgtgcg ttctgagcgt gttggccagt ggctgtggag gggaccacct gccacccacg 460980
gtcaccactc ccttgtggca gctttctctt caaataggaa gaacgcacag agggcaggag 461040
cctcctgttt gcagacgttg gcgggccccg aggctcccag agcagcctct gtcaccgctt 461100
ctgtgtagca aacattaacg atgacagggg tagaaattct tcggtgccgt tcagcttaca 461160
aggatcagcc atgtgcctct gtactatgtc cactttgcaa tatttaccga cagccgtctt 461220
ttgttctttc tttcctgttt tccattttta aactagtaac agcaggcctt ttgcgtttac 461280
aatggaacac aatcaccaag aaattagtca gggcgaaaag aaaaaaataa tactattaat 461340
aagaaaccaa caaacaagaa cctctctttc tagggatttc taaatatata aaatgactgt 461400
tccttagaat gtttaactta agaattattt cagtttgtct gggccacact ggggcagagg 461460
ggggagggag ggatacagag atggatgcca cttacctcag atcttttaaa gtggaaatcc 461520
aaattgaatt ttcatttgga ctttcaggat aattttctat gttggtcaac ttttcgtttt 461580
ccctaactca cccagtttag tttgggatga tttgatttct gttgttgttg atcccatttc 461640
taacttggaa ttgtgagcct ctatgttttc tgttaggtga gtgtgttggg ttttttcccc 461700
ccaccaggaa gtggcagcat ccctccttct cccctaaagg gactctgcgg aacctttcac 461760
acctctttct cagggacggg gcaggtgtgt gtgtggtaca ctgacgtgtc cagaagcagc 461820
actttgactg ctctggagta gggttgtaca atttcaagga atgtttggat ttcctgcatc 461880
ttgtggatta ctccttagat accgcataga ttgcaatata atgctgcatg ttcaagatga 461940
acagtagctc ctagtaatca taaaatccac tctttgcaca gtttgatctt tactgaaata 462000
tgttgccaaa atttattttt gttgttgtag ctctggattt tgttttgttt tgttttttaa 462060
ggaaacgatt gacaataccc tttaacatct gtgactacta aggaaaccta tttctttcat 462120
agagagaaaa atctccaatg cttttgaaga cactaatacc gtgctatttc agatatgggt 462180
gaggaagcag agctctcggt accgaaggcc gggcttcttg agctgtgttg gttgtcatgg 462240
ctactgtttc atgaaccaca agcagctcaa cagactggtc tgttgccttc tgaaaccctt 462300
tgcacttcaa tttgcaccag gtgaaaacag ggccagcaga ctccatggcc caattcggtt 462360
tcttcggtgg tgatgtgaaa ggagagaatt acactttttt tttttttaag tggcgtggag 462420
gcctttgctt ccacatttgt ttttaaccca gaatttctga aatagagaat ttaagaacac 462480
atcaagtaat aaatatacag agaatatact tttttataaa gcacatgcat ctgctattgt 462540
gttgggttgg tttcctctct tttccacgga cagtgttgtg tttctggcat agggaaactc 462600
caaacaactt gcacacctct actccggagc tgagatttct tttacataga tgacctcgct 462660
tcaaatacgt taccttactg atgataggat cttttcttgt agcactatac cttgtgggaa 462720
ttttttttta aatgtacacc tgatttgaga agctgaagaa aacaaaattt tgaagcactc 462780
actttgagga gtacaggtaa tgttttaaaa aattgcacaa aagaaaaatg aatgtcgaaa 462840
tgattcattc agtgtttgaa agatatggct ctgttgaaac aatgagtttc atactttgtt 462900
tgtaaaaaaa aaaaagcaga gaagggttga aagttacatg tttttttgta tatagaaatt 462960
tgtcatgtct aaatgatcag atttgtatgg ttatggcctg gaagaattac tacgtaaaag 463020
gctcttaaac tatacctatg cttattgtta tttttgttac atatagccct cgtctgaggg 463080
aggggaactc ggtattctgc gatttgagaa tactgttcat tcctatgctg aaagtacttc 463140
tctgagctcc cttcttagtc taaactctta agccattgca acttcttttt cttcagagat 463200
gatgtttgac attttcagca cttcctgttc ctataaaccc aaagaatata atcttgaaca 463260
cgaagtgttt gtaacaaggg atccaggcta ccaatcaaac aggactcatt atggggacaa 463320
aaaaaaaaat tatttcacct tctttccccc cacacctcat ttaaatgggg ggagtaaaaa 463380
catgatttca atgtaaatgc ctcattttat tttagtttta ttttgatttt tatttaatat 463440
aaagaggcca gaataaatac ggagcatctt ctcagaatag tattcctgtc caaaaatcaa 463500
gccggacagt ggaaactgga cagctgtggg gatattaagc acccccactt acaattctta 463560
aattcagaat ctcgtcccct cccttctcgt tgaaggcaac tgttctggta gctaactttc 463620
tcctgtgtaa tggcgggagg gaacaccggc ttcagttttt catgtcccca tgacttgcat 463680
acaaatggtt caactgtatt aaaattaagt gcatttggcc aataggtagt atctatacaa 463740
taacaacaat ctctaagaat ttccataact tttcttatct gaaaggactc aagtcttcca 463800
ctgcagatac attggaggct tcacccacgt tttctttccc tttagtttgt ttgctgtctg 463860
gatggccaat gagcctgtct ccttttctgt ggccaatctg aaggccttcg ttggaagtgt 463920
tgtttacagt aatccttacc aagataacat actgtcctcc agaataccaa gtattaggtg 463980
acactagctc aagctgttgt cttcagagca gttaccaaga agctcggtgc acaggttttc 464040
tctggttctt acaggaacca cctactcttt cagttttctg gcccaggagt ggggtaaatc 464100
ctttagttag tgcatttgaa cttgatacct gtgcattcag ttctgtgaat actgcccttt 464160
ttggcggggt ttcctcatct ccccagcctg aactgctcaa ctctaaaccc aaattagtgt 464220
cagccgaaag gaggtttcaa gatagtcctg tcagtatttg tggtgacctt cagattagac 464280
agtcttcatt tccagccagt ggagtcctgg ctccagagcc atctctgaga ctcgtactac 464340
tggatgtttt aatatcagat cattacccac catatgcctc ccacaggcca agggaaaaca 464400
gacaccagaa cttgggttga gggcactacc agactgacat ggccagtaca gaggagaact 464460
agggaaggaa tgatgttttg caccttattg aaaagaaaat tttaagtgca tacataatag 464520
ttaagagctt ttattgtgac aggagaactt ttttccatat gcgtgcatac tctctgtaat 464580
tccagtgtaa aatattgtac ttgcactagc ttttttaaac aaatattaaa aaatggaaga 464640
attcatattc tattttctaa tcgtggtgtg tctatttgta ggatacactc gagtctgttt 464700
attgaatttt atggtccctt tctttgatgg tgcttgcagg ttttctaggt agaaattatt 464760
tcattattat aataaaacaa tgtttgattc aaaatttgaa caaaattgtt ttaaataaat 464820
tgtctgtata ccagtacaag tttattgttt cagtatactc gtactaataa aataacagtg 464880
ccaattgcag atgtgtgtct ttgccttctg ttgggtcctc aaggaagagg ccaggaaaag 464940
agtgctaatt cctcctcctt attgaccccc gctcacgagt tctccctggg taggtcggag 465000
gtagggaggt gtgacatgag gcattgcctt cgctgctaat gttttggggg gaagagtacg 465060
tgtgagatga ggttctaaga taaaaggcac acagccacac ctgatgtctt ggtttcttca 465120
gttcatgttt atgcctccta gctgaacact gctgttcaca agaggtatac ttgtctttaa 465180
acatgtggta gcttcatgcg ctcgtgtggc ataatctata cactccttac agatttgctc 465240
taaactggtt agtggtctgt aagtggaaaa tttattttta cttcctgtaa ttcaagctca 465300
ttagaaattc agcgagcaga ccgggcacag tggctcacgc ccataatccc aacagttggg 465360
gaggccgagg cacaaggcct gcttgagccc aggagttcga gaccagccta gtcaacatag 465420
taagacctca tctctacaaa aaatgaaatt agccgggtgt ggtggcacat acctatggtc 465480
ccagctactt aggggactga ggtgggagga tcgcctgggg ccaggaggtc gaggctgcag 465540
tgagccataa tcataccgct gcactccagc ctgggcgaca gagcaaaact ctgcctcaaa 465600
aacaaaaaaa aaacccaact cctcgagcag gtctctcagc atgtggagga actccccgtt 465660
tacctcaaga gtaccacatt acagctttgc actgggccca gtcttggaaa gatatggctt 465720
agcagttgtg ccagaaaaag taattcctca agaacccata gcttccaggt ggaatcccct 465780
gcacccacct caacccacct caacccacct caagaccttc cagcctcaag gttacacaga 465840
ggtgggagaa cgcttggggt taaattcatt ttcacttagc caaggaggaa ctatcttctt 465900
gggaaggtgt tttggactct cctctgatta tttagttgag gtcctgacac attatataat 465960
aaatatgtga aaggacacac agcaaaccag agctgtgtag gtgcaactca ggctacaagg 466020
gctgccccag gtcctgtgga gtagcccggg caaatgtgcc tgtgtgctgt gggcaaactc 466080
ggcaaagcag tctgcatctc tgccttccct ttttgtttgt gtgagatact gattgttctg 466140
acaagtttgg ggtccagtgg ctgtgttact tacctcagct ggtgaaatca attaggggga 466200
accatacctt caggtgctgc agcggggcag gacttgaaac catcaaaagc actgccagag 466260
ccctcagatg gaacggccag agtggcccaa ggcaaatggc gtcgagttca ctggctgtcc 466320
tcctcctccc ccagctctgg cacaggaagc ccagtgggtc agcagcaaag ctgcatgctt 466380
catctccagg tcctgtggga cacccggtcc aagggacact ctggtgtggg ctcccccagc 466440
cccactccta tcagaggcag agatgaacct gctaaggcaa acggtgacgg agccttacaa 466500
gttctcttta tgggccaggc gcggtggctc acacctgtaa tcccagcact ttgggaggct 466560
gaggtgggtg gatcacccga gcccaggagt ttgagaccag cctgggtaac atggcaaaaa 466620
cccatctcta ctaaaaacat aaacattagc cagacgtggc gggcacctgt aatcccggct 466680
actctgaagg ctgaggcacg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 466740
gagattgtgc cactgcactc tgcctgggtg acagagcaag acttggtctc aggaaaaaaa 466800
aaaaaaaaaa agacattctc tttctgaagg ctctgcttca aaatggtcct aacgagtttt 466860
tgattttgta actactcagt tacaagcagc tggaagacca cagagagcaa ggcggggagc 466920
ctgcagccaa gccccatgtc ttgctccacg ttaaatcgcc tcttggccct cccgtctcca 466980
aagtgcagcc cttgtgtttc tacaggtgca agagttattc ttaatgggcc gggcacagtg 467040
gctcacacct gtaatcctag cactttgggg aggttgacgc aggtggatgg cttgagccct 467100
ggagtttgag accagtctgg gcaacatggt gagaccctgt ctctataaaa aatacaaaaa 467160
ttagctgggc gtggtagcag gtgtctgtag tcccagctac ttgggagact gaggtcagag 467220
gatcacctga gcccgggagg tcaaggctgt ggtgagctgt gatcctgcca ctgcactcca 467280
gcctgggcaa cagagaccct gtctcaaatt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 467340
ctcttaatgg atttagtagg ggaaagtatt acaatggaga caatgctgct ggctggatct 467400
ctaaacataa tcttaaagga ccaacagtgg gcctgtatta tcccagagtg tgacagctct 467460
ggttggaccc ttctcatgcc atcggtcact gtggacaatc aggccattca ttcaccctgg 467520
cacagcagca ccctgtggat cttctctact ccagggtcat tgcttgcctt tccaaagaaa 467580
actgacttgt gtatctgctc ttcagcctta ttaaaaagca aagtaaaaca acctgatctg 467640
catacgcttt ccaggcctgg aactcaatac ttcaaagttt agcggccggt catcacttct 467700
tctgcgttca ctgtttaaac aagcatcctg gtggactgct gcaggtcagc tgcagaggcc 467760
aattctccaa gacaatgtca ttgttcccaa cccgttaact gacccttata cagtagtgcc 467820
atgtggtcct tccgagaaag gattcactgg cacactgagg gaatggctct aactcatgtc 467880
tcaaaccaat gccttttagg atgccactga tcaaagcttt ggctcttttt cagtgtgact 467940
ccacctgcta atttcttggg agacaacctt cccataaaac atcctgtgga atttcaaatt 468000
<210> 3
<211> 10587
<212> DNA
<213> Homo sapiens
<400> 3
gaggagagag cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg 60
acctgtttca ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag 120
cagccgcaag acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca 180
tttacacttt acagagcatc gtgcatcaag tcaccagggt ggtccattca agctgcagat 240
ttgtttgtca tccttgtaca gcaatctcct cctccactgc cactacaggg aagtgcatca 300
catgtcagca tactggagca tagtgaaaga gtctattttg aagcttcaaa cttagtgctg 360
ctgcagacca ggaacaagag agaaagagtg gatttcagcc tgcacggatg gtcttgaaac 420
acaaatggtt tttggtctag gcgttttaca ctgagattct ccactgccac cctttctact 480
caagcaaaat cttcgtgaaa agatctgctg caaggaactg atagcttatg gttctccatt 540
gtgatgaaag cacatggtac agttttccaa agaaattaga ccattttctt cgtgagaaag 600
aaatcgacgt gctgttttca tagggtattt ctcacttctc tgtgaaagga agaaagaaca 660
cgcctgagcc caagagccct caggagccct ccagagcctg tgggaagtct ccatggtgaa 720
gtataggctg aggctacctg tgaacagtac gcagtgaatg ttcatccaga gctgctgttg 780
gcggattgta cccacgggga gatgattcct catgaagagc ctggatcccc tacagaaatc 840
aaatgtgact ttccgtttat cagactaaaa tcagagccat ccagacagtg aaacagtcac 900
cgtggagggg ggacggcgaa aaatgaaatc caaccaagag cggagcaacg aatgcctgcc 960
tcccaagaag cgcgagatcc ccgccaccag ccggtcctcc gaggagaagg cccctaccct 1020
gcccagcgac aaccaccggg tggagggcac agcatggctc ccgggcaacc ctggtggccg 1080
gggccacggg ggcgggaggc atgggccggc agggacctcg gtggagcttg gtttacaaca 1140
gggaataggt ttacacaaag cattgtccac agggctggac tactccccgc ccagcgctcc 1200
caggtctgtc cccgtggcca ccacgctgcc tgccgcgtac gccaccccgc agccagggac 1260
cccggtgtcc cccgtgcagt acgctcacct gccgcacacc ttccagttca ttgggtcctc 1320
ccaatacagt ggaacctatg ccagcttcat cccatcacag ctgatccccc caaccgccaa 1380
ccccgtcacc agtgcagtgg cctcggccgc aggggccacc actccatccc agcgctccca 1440
gctggaggcc tattccactc tgctggccaa catgggcagt ctgagccaga cgccgggaca 1500
caaggctgag cagcagcagc agcagcagca gcagcagcag cagcagcatc agcatcagca 1560
gcagcagcag cagcagcagc agcagcagca gcagcagcac ctcagcaggg ctccggggct 1620
catcaccccg gggtcccccc caccagccca gcagaaccag tacgtccaca tttccagttc 1680
tccgcagaac accggccgca ccgcctctcc tccggccatc cccgtccacc tccaccccca 1740
ccagacgatg atcccacaca cgctcaccct ggggcccccc tcccaggtcg tcatgcaata 1800
cgccgactcc ggcagccact ttgtccctcg ggaggccacc aagaaagctg agagcagccg 1860
gctgcagcag gccatccagg ccaaggaggt cctgaacggt gagatggaga agagccggcg 1920
gtacggggcc ccgtcctcag ccgacctggg cctgggcaag gcaggcggca agtcggttcc 1980
tcacccgtac gagtccaggc acgtggtggt ccacccgagc ccctcagact acagcagtcg 2040
tgatccttcg ggggtccggg cctctgtgat ggtcctgccc aacagcaaca cgcccgcagc 2100
tgacctggag gtgcaacagg ccactcatcg tgaagcctcc ccttctaccc tcaacgacaa 2160
aagtggcctg catttaggga agcctggcca ccggtcctac gcgctctcac cccacacggt 2220
cattcagacc acacacagtg cttcagagcc actcccggtg ggactgccag ccacggcctt 2280
ctacgcaggg actcaacccc ctgtcatcgg ctacctgagc ggccagcagc aagcaatcac 2340
ctacgccggc agcctgcccc agcacctggt gatccccggc acacagcccc tgctcatccc 2400
ggtcggcagc actgacatgg aagcgtcggg ggcagccccg gccatagtca cgtcatcccc 2460
ccagtttgct gcagtgcctc acacgttcgt caccaccgcc cttcccaaga gcgagaactt 2520
caaccctgag gccctggtca cccaggccgc ctacccagcc atggtgcagg cccagatcca 2580
cctgcctgtg gtgcagtccg tggcctcccc ggcggcggct ccccctacgc tgcctcccta 2640
cttcatgaaa ggctccatca tccagttggc caacggggag ctaaagaagg tggaagactt 2700
aaaaacagaa gatttcatcc agagtgcaga gataagcaac gacctgaaga tcgactccag 2760
caccgtagag aggattgaag acagccatag cccgggcgtg gccgtgatac agttcgccgt 2820
cggggagcac cgagcccagg tcagcgttga agttttggta gagtatcctt tttttgtgtt 2880
tggacagggc tggtcatcct gctgtccgga gagaaccagc cagctctttg atttgccgtg 2940
ttccaaactc tcagttgggg atgtctgcat ctcgcttacc ctcaagaacc tgaagaacgg 3000
ctctgttaaa aagggccagc ccgtggatcc cgccagcgtc ctgctgaagc actcaaaggc 3060
cgacggcctg gcgggcagca gacacaggta tgccgagcag gaaaacggaa tcaaccaggg 3120
gagtgcccag atgctctctg agaatggcga actgaagttt ccagagaaaa tgggattgcc 3180
tgcagcgccc ttcctcacca aaatagaacc cagcaagccc gcggcaacga ggaagaggag 3240
gtggtcggcg ccagagagcc gcaaactgga gaagtcagaa gacgaaccac ctttgactct 3300
tcctaagcct tctctaattc ctcaggaggt taagatttgc attgaaggcc ggtctaatgt 3360
aggcaagtag aggcagcgtg ggggaaagga aacgtggctc tcccttatca tttgtatcca 3420
gattactgta ctgtaggcta aaataacaca gtatttacat gttatcttct taattttagg 3480
tttctgttct aaccttgtca ttagagttac agcaggtgtg tcgcaggaga ctggtgcata 3540
tgctttttcc acgagtgtct gtcagtgagc gggcgggagg aagggcacag caggagcggt 3600
cagggctcca ggcatccccg gggaagaaag gaacggggct tcacagtgcc tgccttctct 3660
agcggcacag aagcagccgg gggcgctgac tcccgctagt gtcaggagaa aagtcccgtg 3720
ggaagggtcc tgcaggggtg cagggttgca cgcatgtggg ggtgcacagg cgctgtggcg 3780
gcgagtgagg gtctcttttt ctctgcctcc ctctgcctca ctctcttgct atcggcatgg 3840
gccggggggg ttcagagcag tgtcctcctg gggttcccac gtgcaaaatc aacatcagga 3900
acccagcttc agggcatcgc ggagacgcgt cagatggcag atttggaaag ttaaccattt 3960
aaaagaacat ttttctctcc aacatatttt acaataaaag caacttttaa ttgtatagat 4020
atatatttcc ccctatgggg cctgactgca ctgatatata ttttttttaa agagcaactg 4080
ccacatgcgg gatttcattt ctgcttttta ctagtgcagc gatgtcacca gggtgttgtg 4140
gtggacaggg aagcccctgc tgtcatggcc ccacatgggg taaggggggt tgggggtggg 4200
ggagagggag agagcgaaca cccacgctgg tttctgtgca gtgttaggaa aaccaatcag 4260
gttattgcat tgacttcact cccaagaggt agatgcaaac tgcccttcag tgagagcaac 4320
agaagctctt cacgttgagt ttgcgaaatc tttttgtctt tgaactctag tactgtttat 4380
agttcatgac tatggacaac tcgggtgcca cttttttttt ttttcagatt ccagtgtgac 4440
atgaggaatt agattttgaa gatgagcata tattactatc tttaagcatt taaaaatact 4500
gttcacactt tattaccaag catcttggtc tctcattcaa caagtactgt atctcacttt 4560
aaactctttg gggaaaaaac aaaaacaaaa aaaactaagt tgctttcttt ttttcaacac 4620
tgtaactaca tttcagctct gcagaattgc tgaagagcaa gatattgaaa gtttcaatgt 4680
ggtttaaagg gatgaatgtg aattatgaac tagtatgtga caataaatga ccaccaagta 4740
ctacctgacg ggaggcactt ttcactttga tgtctgagaa tcagttcaag gcatatgcag 4800
agttggcaga gaaactgaga gaaaagggat ggagaagaga atactcattt ttgtccagtg 4860
tttttctttt taagatgaac ttttaaagaa ccttgcgatt tgcacatatt gagtttataa 4920
cttgtgtgat attcctgcag tttttatcca ataacattgt gggaaaggtt tgggggactg 4980
aacgagcata aataaatgta gcaaaatttc tttctaacct gcctaaactc taggccattt 5040
tataaggtta tgttcctttg aaaattcatt ttggtctttt taccacatct gtcacaaaaa 5100
gccaggtctt agcgggctct tagaaactct gagaattttc ttcagattca ttgagagagt 5160
tttccataaa gacatttata tatgtgagca agattttttt taaacaatta ctttattatt 5220
gttgttatta atgttatttt cagaatggct tttttttttc tattcaaaat caaatcgaga 5280
tttaatgttt ggtacaaacc cagaaagggt atttcatagt ttttaaacct ttcattccca 5340
gagatccgaa atatcatttg tgggttttga atgcatcttt aaagtgcttt aaaaaaaagt 5400
tttataagta gggagaaatt tttaaatatt cttacttgga tggctgcaac taaactgaac 5460
aaatacctga cttttctttt accccattga aaatagtact ttcttcgttt cacaaattaa 5520
aaaaaaaatc tggtatcaac ccacattttg gctgtctagt attcatttac atttagggtt 5580
caccaggact aatgattttt ataaaccgtt ttctggggtg taccaaaaac atttgaatag 5640
gtttagaata gctagaatag ttccttgact ttcctcgaat ttcattaccc tctcagcatg 5700
cttgcagaga gctgggtggg ctcattcttg cagtcatact gcttatttag tgctgtattt 5760
tttaaacgtt tctgttcaga gaacttgctt aatcttccat atattctgct cagggcactt 5820
gcaattatta ggttttgttt ttctttttgt tttttagcct ttgatggtaa gaggaatacg 5880
ggctgccaca tagactttgt tctcattaat atcactattt acaactcatg tggactcaga 5940
aaaacacaca ccaccttttg gcttacttcg agtattgaat tgactggatc cactaaacca 6000
acactaagat gggaaaacac acatggtttg gagcaatagg aacatcatca taatttttgt 6060
ggttctattt caggtatagg aattataaaa taattggttc tttctaaaca cttgtcccat 6120
ttcattctct tgctttttta gcatgtgcaa tactttctgt gccaatagag tctgaccagt 6180
gtgctatata gttaaagctc attccctttt ggctttttcc ttgtttggtt gatcttcccc 6240
attctggcca gagcagggct ggagggaagg agccaggagg gagagagcct cccacctttc 6300
ccctgctgcg gatgctgagt gctggggcgg ggagccttca ggagccccgt gcgtctgccg 6360
ccacgttgca gaaagagcca gccaaggaga cccgggggag gaaccgcagt gtcccctgtc 6420
accacacgga atagtgaatg tggagtgtgg agaggaagga ggcagattca tttctaagac 6480
gcactctgga gccatgtagc ctggagtcaa cccattttcc acggtctttt ctgcaagtgg 6540
gcaggcccct cctcggggtc tgtgtccttg agacttggag ccctgcctct gagcctggac 6600
gggaagtgtg gcctgttgtg tgtgtgcgtt ctgagcgtgt tggccagtgg ctgtggaggg 6660
gaccacctgc cacccacggt caccactccc ttgtggcagc tttctcttca aataggaaga 6720
acgcacagag ggcaggagcc tcctgtttgc agacgttggc gggccccgag gctcccagag 6780
cagcctctgt caccgcttct gtgtagcaaa cattaacgat gacaggggta gaaattcttc 6840
ggtgccgttc agcttacaag gatcagccat gtgcctctgt actatgtcca ctttgcaata 6900
tttaccgaca gccgtctttt gttctttctt tcctgttttc catttttaaa ctagtaacag 6960
caggcctttt gcgtttacaa tggaacacaa tcaccaagaa attagtcagg gcgaaaagaa 7020
aaaaataata ctattaataa gaaaccaaca aacaagaacc tctctttcta gggatttcta 7080
aatatataaa atgactgttc cttagaatgt ttaacttaag aattatttca gtttgtctgg 7140
gccacactgg ggcagagggg ggagggaggg atacagagat ggatgccact tacctcagat 7200
cttttaaagt ggaaatccaa attgaatttt catttggact ttcaggataa ttttctatgt 7260
tggtcaactt ttcgttttcc ctaactcacc cagtttagtt tgggatgatt tgatttctgt 7320
tgttgttgat cccatttcta acttggaatt gtgagcctct atgttttctg ttaggtgagt 7380
gtgttgggtt ttttcccccc accaggaagt ggcagcatcc ctccttctcc cctaaaggga 7440
ctctgcggaa cctttcacac ctctttctca gggacggggc aggtgtgtgt gtggtacact 7500
gacgtgtcca gaagcagcac tttgactgct ctggagtagg gttgtacaat ttcaaggaat 7560
gtttggattt cctgcatctt gtggattact ccttagatac cgcatagatt gcaatataat 7620
gctgcatgtt caagatgaac agtagctcct agtaatcata aaatccactc tttgcacagt 7680
ttgatcttta ctgaaatatg ttgccaaaat ttatttttgt tgttgtagct ctggattttg 7740
ttttgttttg ttttttaagg aaacgattga caataccctt taacatctgt gactactaag 7800
gaaacctatt tctttcatag agagaaaaat ctccaatgct tttgaagaca ctaataccgt 7860
gctatttcag atatgggtga ggaagcagag ctctcggtac cgaaggccgg gcttcttgag 7920
ctgtgttggt tgtcatggct actgtttcat gaaccacaag cagctcaaca gactggtctg 7980
ttgccttctg aaaccctttg cacttcaatt tgcaccaggt gaaaacaggg ccagcagact 8040
ccatggccca attcggtttc ttcggtggtg atgtgaaagg agagaattac actttttttt 8100
tttttaagtg gcgtggaggc ctttgcttcc acatttgttt ttaacccaga atttctgaaa 8160
tagagaattt aagaacacat caagtaataa atatacagag aatatacttt tttataaagc 8220
acatgcatct gctattgtgt tgggttggtt tcctctcttt tccacggaca gtgttgtgtt 8280
tctggcatag ggaaactcca aacaacttgc acacctctac tccggagctg agatttcttt 8340
tacatagatg acctcgcttc aaatacgtta ccttactgat gataggatct tttcttgtag 8400
cactatacct tgtgggaatt tttttttaaa tgtacacctg atttgagaag ctgaagaaaa 8460
caaaattttg aagcactcac tttgaggagt acaggtaatg ttttaaaaaa ttgcacaaaa 8520
gaaaaatgaa tgtcgaaatg attcattcag tgtttgaaag atatggctct gttgaaacaa 8580
tgagtttcat actttgtttg taaaaaaaaa aaagcagaga agggttgaaa gttacatgtt 8640
tttttgtata tagaaatttg tcatgtctaa atgatcagat ttgtatggtt atggcctgga 8700
agaattacta cgtaaaaggc tcttaaacta tacctatgct tattgttatt tttgttacat 8760
atagccctcg tctgagggag gggaactcgg tattctgcga tttgagaata ctgttcattc 8820
ctatgctgaa agtacttctc tgagctccct tcttagtcta aactcttaag ccattgcaac 8880
ttctttttct tcagagatga tgtttgacat tttcagcact tcctgttcct ataaacccaa 8940
agaatataat cttgaacacg aagtgtttgt aacaagggat ccaggctacc aatcaaacag 9000
gactcattat ggggacaaaa aaaaaaatta tttcaccttc tttcccccca cacctcattt 9060
aaatgggggg agtaaaaaca tgatttcaat gtaaatgcct cattttattt tagttttatt 9120
ttgattttta tttaatataa agaggccaga ataaatacgg agcatcttct cagaatagta 9180
ttcctgtcca aaaatcaagc cggacagtgg aaactggaca gctgtgggga tattaagcac 9240
ccccacttac aattcttaaa ttcagaatct cgtcccctcc cttctcgttg aaggcaactg 9300
ttctggtagc taactttctc ctgtgtaatg gcgggaggga acaccggctt cagtttttca 9360
tgtccccatg acttgcatac aaatggttca actgtattaa aattaagtgc atttggccaa 9420
taggtagtat ctatacaata acaacaatct ctaagaattt ccataacttt tcttatctga 9480
aaggactcaa gtcttccact gcagatacat tggaggcttc acccacgttt tctttccctt 9540
tagtttgttt gctgtctgga tggccaatga gcctgtctcc ttttctgtgg ccaatctgaa 9600
ggccttcgtt ggaagtgttg tttacagtaa tccttaccaa gataacatac tgtcctccag 9660
aataccaagt attaggtgac actagctcaa gctgttgtct tcagagcagt taccaagaag 9720
ctcggtgcac aggttttctc tggttcttac aggaaccacc tactctttca gttttctggc 9780
ccaggagtgg ggtaaatcct ttagttagtg catttgaact tgatacctgt gcattcagtt 9840
ctgtgaatac tgcccttttt ggcggggttt cctcatctcc ccagcctgaa ctgctcaact 9900
ctaaacccaa attagtgtca gccgaaagga ggtttcaaga tagtcctgtc agtatttgtg 9960
gtgaccttca gattagacag tcttcatttc cagccagtgg agtcctggct ccagagccat 10020
ctctgagact cgtactactg gatgttttaa tatcagatca ttacccacca tatgcctccc 10080
acaggccaag ggaaaacaga caccagaact tgggttgagg gcactaccag actgacatgg 10140
ccagtacaga ggagaactag ggaaggaatg atgttttgca ccttattgaa aagaaaattt 10200
taagtgcata cataatagtt aagagctttt attgtgacag gagaactttt ttccatatgc 10260
gtgcatactc tctgtaattc cagtgtaaaa tattgtactt gcactagctt ttttaaacaa 10320
atattaaaaa atggaagaat tcatattcta ttttctaatc gtggtgtgtc tatttgtagg 10380
atacactcga gtctgtttat tgaattttat ggtccctttc tttgatggtg cttgcaggtt 10440
ttctaggtag aaattatttc attattataa taaaacaatg tttgattcaa aatttgaaca 10500
aaattgtttt aaataaattg tctgtatacc agtacaagtt tattgtttca gtatactcgt 10560
actaataaaa taacagtgcc aattgca 10587
<210> 4
<211> 1676
<212> DNA
<213> Homo sapiens
<400> 4
ggggaggaga gagcagagta taccgcagac atcatttcta ctacagtggc ggagccgtac 60
aggacctgtt tcactgcagg gggatccaaa acaagccccg tggagcagca gccagagcaa 120
cagcagccgc aagacattgt ttctctcctt ctgccccccc ttccccacgc aaccccagat 180
ccatttacac tttacagtca cagaacagaa agtgctggtg gacatctctt cttgccccaa 240
gatcttcgtt ggaagtcccc gggacttggt gtctttgccg ttcaaagtgt ttatgaactc 300
gccaggaggc ataatgtgtc accattttat tctgggccac cctaaaggat gacacccagc 360
ttcagagacc tcctcttgga cgacatccct gagaatcaat gttttagctg tcccatagtc 420
tgacgtctgt ttccgaccgc ttttgagctg gcgcaggctt agtcattaat ggccaggacg 480
atgttaaatg ttctgcctga ttggcttgca gctacacacc ttttgtcatt tgcagagcag 540
caactccctc ttgagctctt ggggagtctt tacacaaata cactagaaaa aaggcaccca 600
tccatttttt ttccatcttg gcattagctc acaggcatag tcctgggatg acctggagta 660
gaggcagtgg aggataaatt catcttgcac agacttgttt gtgctagttc tagcctgtct 720
ctcgccacag atctagcttt taaatactca agtgattggt tttgtgtagg aatgtgtgga 780
ttgttggatt ggaagaattt tctccctgga tttctagtgt ttacataagc agatacaaaa 840
aaaatttgat cactgattta aatagcaggg cttattttaa aaagttatgg gtgcttcaag 900
gtggtacaga ataaaaatgt cagggttttt tttttttttt ttttttaaca agtcgtaaca 960
caaccaaaat gtatatatta atgttttgtc aggaaagggt caaaatggaa aatttgcaac 1020
aaagacaaac tacaatagaa caagtgcaaa cagaagctga caaatatatg cccctcgttg 1080
ggagttcagc ccatggaatg ttatgtagga caaaaggaat ggaagagata tttcagtaac 1140
attttgttct ctgtcaaaaa ccttctgaaa tataaatctg ctgtgtattg gagaatggat 1200
acagcaattg attcaagttg aatagctttc atttaactag aatatcccac agaaagcagt 1260
tcttgttctg acaaccatat ttttgctttc tttcacttaa agaaaattga attcatgttt 1320
acatatctta tagggttgtt ttatggacaa agacacgggt caaaccccat cacagtggct 1380
agtgttacaa caaatagaaa catttctaaa tgaaataaca tttctaagcc agggccagtg 1440
cctgcagtaa taatactagg ttggtattat gaagccattt gcaactataa ataattcagt 1500
catagatgtg ctttttttaa aatcctggtt ttttaaaatt ctagtctttt gccaatacac 1560
acacccatac acatacttca cctatttgca taatagagga ggaatatgaa tatgtatata 1620
ataaagtcac tttattttgg acttgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1676
<210> 5
<211> 924
<212> DNA
<213> Homo sapiens
<400> 5
gaggaggagg gatcacttga gttgagctct gctgactaga ttgcatttct gtgggaagag 60
atggatggag catgaggaag gccatgtgtg tgtctgggac ataacaagcc aatgcacgca 120
tactggagca tagtgaaaga gtctattttg aagcttcaaa cttagtgctg ctgcagacca 180
ggaacaagag agaaagagtg gatttcagcc tgcacggatg gtcttgaaac acaaatggtt 240
tttggtctag gcgttttaca ctgagattct ccactgccac cctttctact caagcaaaat 300
cttcgtgaaa agatctgctg caaggaactg atagcttatg gttctccatt gtgatgaaag 360
cacatggtac agttttccaa agaaattaga ccattttctt cgtgagaaag aaatcgacgt 420
gctgttttca tagggtattt ctcacttctc tgtgaaagga agaaagaaca cgcctgagcc 480
caagagccct caggagccct ccagagcctg tgggaagtct ccatggtgaa gtataggctg 540
aggctacctg tgaacagtac gcagtgaatg ttatctgatg cacaaaggaa aataataata 600
caaaacccat aacctattca ttgtattgtt gcggtagatc gagctacatg ctgcacagca 660
aaagaccttc tttgcacttc tttcaagcag aattattgct gtatattcac tctgaactga 720
gagatcattg caaaaaaaaa aaagaagaag aagaagagaa gaaaagaaaa aagaaatagg 780
ttaagcaaat tttgtggtgg tgcttatgtg tgcacagaca tgcatgaggc ctccgcatct 840
tccaaacttg gaaagcatat tttaacagca caaatatatc tacatgtttg atccaaaaaa 900
aaaaaaaaaa aaaaaaaaaa aaaa 924
<210> 6
<211> 3375
<212> DNA
<213> Homo sapiens
<400> 6
gtataccgca gacatcattt ctactacagt ggcggagccg tacaggacct gtttcactgc 60
agggggatcc aaaacaagcc ccgtggagca gcagccagag caacagcagc cgcaagacat 120
tgtttctctc cctctgcccc cccttcccca cgcaacccca gatccattta cactttacag 180
agcatcgtgc atcaagtcac cagggtggtc cattcaagct gcagatttgt ttgtcatcct 240
tgtacagcaa tctcctcctc cactgccact acagggaagt gcatcacatg tcaggtcaca 300
gaacagaaag tgctggtgga catctcttct tgccccaaga tcttcgttgg aagtccccgg 360
gacttggtgt ctttgccgtt caaagtgttt atgaactcgc caggaggcat aatgtgtcac 420
cattttattc tgggccaccc taaaggatga cacccagctt cagagacctc ctcttggacg 480
acatccctga gaatcaatgt tttagctgtc ccatagtctg acgtctgttt ccgaccgctt 540
ttgagctggc gcaggcttag tcattaatgg ccaggacgat gttaaatgtt ctgcctgatt 600
ggcttgcagc tacacacctt ttgtcatttg cagagcagca actccctctt gagctcttgg 660
ggagtcttta cacaaataca ctagaaaaaa ggcacccatc catttttttt ccatcttggc 720
attagctcac aggcatagtc ctgggatgac ctggagtaga ggcagtggag gataaattca 780
tcttgcacag acttgtttgt gctagttcta gcctgtctct cgccacagat ctagctttta 840
aatactcaag tgattggttt tgtgtaggaa tgtgtggatt gttggattgg aagaattttc 900
tccctggatt tctagtgttt acataagcag atacaaaaaa aatttgatca ctgatttaaa 960
tagcagggct tattttaaaa agttatgggt gcttcaaggt ggtacagaat aaaaatgtca 1020
gggttttgtt tttttttttt ttttaacaag tcgtaacaca accaaaatgt atatattaat 1080
gttttgtcag gaaagggtca aaatggaaaa tttgcaacaa agacaaacta caatagaaca 1140
agtgcaaaca gaagctgaca aatatatgcc cctcgttggg agttcagccc atggaatgtt 1200
atgtaggaca aaaggaatgg aagagatatt tcagtaacat tttgttctct gtcaaaaacc 1260
ttctgaaata taaatctgct gtgtattgga gaatggatac agcaattgat tcaagttgaa 1320
tagctttcat ttaactagaa tatcccacag aaagcagttc ttgttctgac aaccatattt 1380
ttgctttctt tcacttaaag aaaattgaat tcatgtttac atatcttata gggttgtttt 1440
atggacaaag acacgggtca aaccccatca cagtggctag tgttacaaca aatagaaaca 1500
tttctaaatg aaataacatt tctaagccag ggccagtgcc tgcagtaata atactaggtt 1560
ggtattatga agccatttgc aactataaat aattcagtca tagatgtgct ttttttaaaa 1620
tcctggtttt ttaaaattct agtcttttgc caatacacac acccatacac atacttcacc 1680
tatttgcata atagaggagg aatatgaata tgtatataat aaagtcactt tattttggac 1740
tttctgaaac agattacctt ttttcttctc ctcatgatgg ctccctgagt tgcttccaat 1800
tgttgaaatt ccataattac ccacaaatat ggatgtgccc ttctaagggt cttgccatgt 1860
caaccagccc agctgaaagc taatagccag tgttagcggt ttaaggaact gagcttcaga 1920
attgagagcc cccagcaaag gaagttctgt ttttattctc catttctact ctcctcaagg 1980
agaaattagg tgtttattgt tttgttttgt tttttaaatt cccagatcat tctggcattg 2040
gtcctggatt cgctgcaaat gtaattttta gcaacatcta ttactcctga aatattttgg 2100
ctcttcgtgg cctgtatgat tcagtagact ctgaggtttt ccaagtacat taaggactta 2160
aatacagaat gtcttaaaat tttagggcta ttgatcaaga gaaagcttct cgaggaataa 2220
agttctgtta ggttttagcc ctattctgct ttcaaaattc ttaactggat gccgtctatt 2280
ttgttttctt tctgtgttta taactaattt gctacttggg tttattgttt tcttacttag 2340
aaactacttt tttttttgtt ttgtaaatgc acagcactta aaaatataaa acagttccaa 2400
acagttccaa cctgttcatt gtttatacct tgaccatctt ttctgtctta ttgctgaacc 2460
atcgcttctc tttctacttc tcttctggga tttcatcttg ctcagctaaa attctagtgt 2520
gttattctga atattatggc tggagtttcc tgaccaactt cttgcatctg agtccatttc 2580
ctgtgcttaa ggctgctggc attccattca ctgctcctag tcaaaactga aacttctcct 2640
gctaatgaga ttaggcctta caacactatt aatttcttcc tctctatttc ttgctccatt 2700
gttatttctc agagatgaaa atctatttgt cattatgaga ttcattttgg catcacttac 2760
taaagttccc ttggattttt ctgttcttca tacaccctac agcttcaaac tgcaacagtc 2820
atcaactggt ctttgacaaa ttagttgtct ctacacatgg tttacaatat tacactagct 2880
gtttaaaaat aattaagctt ctttctgtgt tctttgctgt gggtcaggaa ctttacttcc 2940
tttgccatgc aacacagaag ttaatcacaa atgggtcctc tgaaccaaat aattaaaaat 3000
agagcaaagt ttctgaacca ggcggttggc agaaacgtct gtacttccat ctgtgcatgg 3060
ttaggaaaat atttcacgat atttaaatag catcagcttt gctctctttt gtgtgagagt 3120
gtgtctgtgt gtctatgcgt aattcattgc tttgaaggtt tgtttgactg ttagataatc 3180
atataaaaaa agttactggc aaggaaacag gaaagcaaat ccaggtgttt tgtgcataca 3240
ttctttattt accagtctct gtgaaggagc aatgatcttg cttttgcttt tctctctgac 3300
tgaaagtttt tgccttgtta tgtgctgcag aaaactaaat aacattgcat tttgactttg 3360
aaaaaaaaaa aaaaa 3375
<210> 7
<400> 7
000
<210> 8
<400> 8
000
<210> 9
<400> 9
000
<210> 10
<400> 10
000
<210> 11
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 11
catccagagt gcagagataa gc 22
<210> 12
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 12
actctaccaa aacttcaacg ct 22
<210> 13
<211> 25
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 13
agaggattga agacagccat agccc 25
<210> 14
<211> 21
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 14
gtataggctg aggctacctg t 21
<210> 15
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 15
gatccaggct cttcatgagg 20
<210> 16
<211> 26
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 16
acagcagctc tggatgaaca ttcact 26
<210> 17
<211> 15
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 17
tcgccgcttg ctgca 15
<210> 18
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 18
atcggccgtg atgtcga 17
<210> 19
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 19
ccatggtcaa ccccaccgtg ttc 23
<210> 20
<400> 20
000
<210> 21
<400> 21
000
<210> 22
<400> 22
000
<210> 23
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 23
ctgcggtata ctctgctctc 20
<210> 24
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 24
ggaggaggag attgctgtac 20
<210> 25
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 25
gtgcaggctg aaatccactc 20
<210> 26
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 26
gtgttctttc ttcctttcac 20
<210> 27
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 27
atttcatttt tcgccgtccc 20
<210> 28
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 28
ctttgtgtaa acctattccc 20
<210> 29
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 29
tcagctttct tggtggcctc 20
<210> 30
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 30
gtgtggtctg aatgaccgtg 20
<210> 31
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 31
gtcttccacc ttctttagct 20
<210> 32
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 32
ggctgtcttc aatcctctct 20
<210> 33
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 33
tccgttttcc tgctcggcat 20
<210> 34
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 34
acttgcctac attagaccgg 20
<210> 35
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 35
accgctcctg ctgtgccctt 20
<210> 36
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 36
cgctctctcc ctctccccca 20
<210> 37
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 37
tgtttttgtt ttttccccaa 20
<210> 38
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 38
attgaaactt tcaatatctt 20
<210> 39
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 39
cccttttctc tcagtttctc 20
<210> 40
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 40
ttttttttaa agcactttaa 20
<210> 41
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 41
gatttttttt ttaatttgtg 20
<210> 42
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 42
tgtgtgtttt tctgagtcca 20
<210> 43
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 43
gtgttttccc atcttagtgt 20
<210> 44
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 44
tgggaggctc tctccctcct 20
<210> 45
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 45
cggtaaatat tgcaaagtgg 20
<210> 46
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 46
gtttgttggt ttcttattaa 20
<210> 47
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 47
ggcatccatc tctgtatccc 20
<210> 48
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 48
cattggagat ttttctctct 20
<210> 49
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 49
tctctatttc agaaattctg 20
<210> 50
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 50
atctatgtaa aagaaatctc 20
<210> 51
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 51
aattttttaa aacattacct 20
<210> 52
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 52
ggtatagttt aagagccttt 20
<210> 53
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 53
gcctctttat attaaataaa 20
<210> 54
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 54
tctgaattta agaattgtaa 20
<210> 55
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 55
acctaatact tggtattctg 20
<210> 56
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 56
gtgtctgttt tcccttggcc 20
<210> 57
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 57
gtatgcactt aaaattttct 20
<210> 58
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 58
atagaatatg aattcttcca 20
<210> 59
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 59
attggcactg ttattttatt 20
<210> 60
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 60
ggctctttaa atattactcc 20
<210> 61
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 61
gtttgactag atgtgcttct 20
<210> 62
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 62
tcttgagctt ttaattttac 20
<210> 63
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 63
tgctcctttt atcattgtca 20
<210> 64
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 64
cggtggtttg ttgtaccctt 20
<210> 65
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 65
tgtactctat aattttttaa 20
<210> 66
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 66
tgagctgctt ttcatattct 20
<210> 67
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 67
caatagacaa aaattatcat 20
<210> 68
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 68
tttccgaagc tgctatatgt 20
<210> 69
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 69
gtctctcttt ttctaagtca 20
<210> 70
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 70
agactaatat atatatatat 20
<210> 71
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 71
gggtctcttc atctaccttc 20
<210> 72
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 72
tgttcctttc ttctttgttc 20
<210> 73
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 73
gggtgtgtat tcaattctct 20
<210> 74
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 74
gtgactttaa agctttcctg 20
<210> 75
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 75
actgagaggc atctccagtg 20
<210> 76
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 76
tgtcaactag ttcttatcac 20
<210> 77
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 77
ggtaagggcc actaaatctg 20
<210> 78
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 78
cttaccacag agacatgccc 20
<210> 79
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 79
ggagtattat aacaatttgc 20
<210> 80
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 80
gtctgggctg atgatgctgg 20
<210> 81
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 81
gtctgccttt aacatttttc 20
<210> 82
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 82
tgttgtttat aagtttacgg 20
<210> 83
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 83
tgcagcttat tttataggtg 20
<210> 84
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 84
cggtgtctta atatcctcag 20
<210> 85
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 85
gttcctcatc ttaatcacag 20
<210> 86
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 86
gtgactcatc ttggctacag 20
<210> 87
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 87
attttccatg tgtcacctgg 20
<210> 88
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 88
gtgcagtgtc agcagtgcct 20
<210> 89
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 89
gttgtcttac tgatctggag 20
<210> 90
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 90
tgagacctct ctctacttgc 20
<210> 91
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 91
tcagtccttg gtggaagtgt 20
<210> 92
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 92
tctgttgttt aaatatgtct 20
<210> 93
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 93
tctttcatct ctggatgccc 20
<210> 94
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 94
gtgttctatc tccagagtct 20
<210> 95
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 95
tggtgaagat aatgatgatc 20
<210> 96
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 96
tccagtttta ataaaagttc 20
<210> 97
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 97
attttactta atttttacaa 20
<210> 98
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 98
atgtgcatat atacatagac 20
<210> 99
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 99
cttttctact tcatcttctt 20
<210> 100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 100
gtgttctctg gtgagcccca 20
<210> 101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 101
tgtagtagaa atgatgtctg 20
<210> 102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 102
aaatagactc tttcactatg 20
<210> 103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 103
gtggcagtgg agaatctcag 20
<210> 104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 104
tcagcctata cttcaccatg 20
<210> 105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 105
ggttggattt catttttcgc 20
<210> 106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 106
tccactgtat tgggaggacc 20
<210> 107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 107
ctcagctttc ttggtggcct 20
<210> 108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 108
cgcttccatg tcagtgctgc 20
<210> 109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 109
tctgttttta agtcttccac 20
<210> 110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 110
ggcgaactgt atcacggcca 20
<210> 111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 111
tggttgattc cgttttcctg 20
<210> 112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 112
cctacagtac agtaatctgg 20
<210> 113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 113
cacgggactt ttctcctgac 20
<210> 114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 114
gttcgctctc tccctctccc 20
<210> 115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 115
ttgtttttgt tttttcccca 20
<210> 116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 116
catttattgt cacatactag 20
<210> 117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 117
ggttctttaa aagttcatct 20
<210> 118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 118
ctttttttta aagcacttta 20
<210> 119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 119
ggttgatacc agattttttt 20
<210> 120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 120
gtgtgtgttt ttctgagtcc 20
<210> 121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 121
atgtgtgttt tcccatctta 20
<210> 122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 122
gtctccttgg ctggctcttt 20
<210> 123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 123
gtgttccatt gtaaacgcaa 20
<210> 124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 124
tcttgtttgt tggtttctta 20
<210> 125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 125
tccactttaa aagatctgag 20
<210> 126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 126
gcacggtatt agtgtcttca 20
<210> 127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 127
tcttaaattc tctatttcag 20
<210> 128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 128
tcttcagctt ctcaaatcag 20
<210> 129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 129
tctgcttttt tttttttaca 20
<210> 130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 130
aagtactttc agcataggaa 20
<210> 131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 131
cgtatttatt ctggcctctt 20
<210> 132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 132
aatacagttg aaccatttgt 20
<210> 133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 133
acagcttgag ctagtgtcac 20
<210> 134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 134
tggtgtctgt tttcccttgg 20
<210> 135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 135
ggaattacag agagtatgca 20
<210> 136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 136
gttttattat aataatgaaa 20
<210> 137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 137
gtagtagttt ttgtgaggta 20
<210> 138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 138
gtcacctttt ctatttgcac 20
<210> 139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 139
attttgactt ttgattggtg 20
<210> 140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 140
gggactctgt ctttatttcc 20
<210> 141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 141
atgtttctat ctaagtccca 20
<210> 142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 142
gtgtgcattt ttaattttgt 20
<210> 143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 143
tgaggacatc atgatggtgc 20
<210> 144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 144
gttttgtttc agtattaggt 20
<210> 145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 145
tacatcctga aaatcacagc 20
<210> 146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 146
ctctcacttt tcttctcctt 20
<210> 147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 147
gtctccttac atagtgctgc 20
<210> 148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 148
atatattaga ctaatatata 20
<210> 149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 149
tcaggtttat atgtatacaa 20
<210> 150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 150
gtttgtttag atttatcctc 20
<210> 151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 151
gtcatagctc tcctctgcac 20
<210> 152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 152
gtcagcatac ttagcttttc 20
<210> 153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 153
cagggctgga ctgagaggca 20
<210> 154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 154
tgagactatt atagtttcca 20
<210> 155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 155
taaaatgcac caatcaacgc 20
<210> 156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 156
gttactttat ttctctaggg 20
<210> 157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 157
atttgtcttg ttgtatgttg 20
<210> 158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 158
gttattttaa atagtggcct 20
<210> 159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 159
tctttggctt ttagacctgt 20
<210> 160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 160
atgttatatc aatgttctgt 20
<210> 161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 161
gtctcagctc aagagtctgt 20
<210> 162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 162
tggcctgtat atctatggac 20
<210> 163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 163
tcagccatag ctcactacag 20
<210> 164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 164
gtcccatttg aatgttttca 20
<210> 165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 165
tcactcatgt ttattttcca 20
<210> 166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 166
tctgaatttc tctgtgggtg 20
<210> 167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 167
tgtactcttc agagaagctg 20
<210> 168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 168
gttaggtgtg tgagacctct 20
<210> 169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 169
tctgtgagtg ttctatttaa 20
<210> 170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 170
tggtgctatg tctatataca 20
<210> 171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 171
tggcctttat acttttgtaa 20
<210> 172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 172
tgtatatttg tctgttttgc 20
<210> 173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 173
cttccttttt ttattttgag 20
<210> 174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 174
tctttatttt ataattaggt 20
<210> 175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 175
tctatggtcc tcagtctcct 20
<210> 176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 176
gtgacactat ttggtttcaa 20
<210> 177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 177
gcttttctac ttcatcttct 20
<210> 178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 178
tgggcttttg atagtgttaa 20
<210> 179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 179
gttgctctgg ctgctgctcc 20
<210> 180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 180
tctctcttgt tcctggtctg 20
<210> 181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 181
gcttgagtag aaagggtggc 20
<210> 182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 182
gtcacatttg atttctgtag 20
<210> 183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 183
tggttggatt tcatttttcg 20
<210> 184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 184
gctgctgctg ctcagccttg 20
<210> 185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 185
ggctgctctc agctttcttg 20
<210> 186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 186
gttgaagttc tcgctcttgg 20
<210> 187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 187
ttctgttttt aagtcttcca 20
<210> 188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 188
cggcgaactg tatcacggcc 20
<210> 189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 189
actcccctgg ttgattccgt 20
<210> 190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 190
ctgtgttatt ttagcctaca 20
<210> 191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 191
gttcctgatg ttgattttgc 20
<210> 192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 192
gtgttcgctc tctccctctc 20
<210> 193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 193
tttttgtttt tgttttttcc 20
<210> 194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 194
ggtcatttat tgtcacatac 20
<210> 195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 195
actgcaggaa tatcacacaa 20
<210> 196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 196
gtttagttgc agccatccaa 20
<210> 197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 197
gggttgatac cagatttttt 20
<210> 198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 198
tggtgtgtgt ttttctgagt 20
<210> 199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 199
attttataat tcctatacct 20
<210> 200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 200
cattcactat tccgtgtggt 20
<210> 201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 201
gtgattgtgt tccattgtaa 20
<210> 202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 202
ttcttgtttg ttggtttctt 20
<210> 203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 203
tcacaattcc aagttagaaa 20
<210> 204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 204
gtaccgagag ctctgcttcc 20
<210> 205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 205
gtgttcttaa attctctatt 20
<210> 206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 206
tgttttcttc agcttctcaa 20
<210> 207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 207
ctctgctttt ttttttttac 20
<210> 208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 208
gtttagacta agaagggagc 20
<210> 209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 209
tccgtattta ttctggcctc 20
<210> 210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 210
agatactacc tattggccaa 20
<210> 211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 211
gcaccgagct tcttggtaac 20
<210> 212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 212
gttctggtgt ctgttttccc 20
<210> 213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 213
gtacaatatt ttacactgga 20
<210> 214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 214
atttatttaa aacaattttg 20
<210> 215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 215
cttgtagtag tttttgtgag 20
<210> 216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 216
ggagggtgct tagtccttcc 20
<210> 217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 217
gtttggcaca cagtaggtgc 20
<210> 218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 218
gtgactgctg ctgatacctg 20
<210> 219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 219
gtttgatatg ctatgctcac 20
<210> 220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 220
tgtttggttg aagtatgtgg 20
<210> 221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 221
atgtgggtat ttaatgtttc 20
<210> 222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 222
gtctttctaa atggttgtac 20
<210> 223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 223
ttcagcatga tctcagttct 20
<210> 224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 224
atgacataat tctaataact 20
<210> 225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 225
tctccttatc ttgtcctctc 20
<210> 226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 226
tattatatat tagactaata 20
<210> 227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 227
gttctatttt ataatagtag 20
<210> 228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 228
tgtgtaatac tccatttttc 20
<210> 229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 229
gtttgtgttg tgttttacag 20
<210> 230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 230
gttttcatac acagttcttc 20
<210> 231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 231
attatattac attatacttg 20
<210> 232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 232
tcctgggttt ttagttttcc 20
<210> 233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 233
tgaggattac atcagtgtaa 20
<210> 234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 234
tcttgggtag atgaggtttg 20
<210> 235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 235
tcttgttttt tcctttcttg 20
<210> 236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 236
gtctcctttg ttccgtgtac 20
<210> 237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 237
gtctttttat ttctctgccc 20
<210> 238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 238
ttgcaagaag gtatgcctag 20
<210> 239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 239
tcctgtttac aacaaagctc 20
<210> 240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 240
tctttctttg ctataatttc 20
<210> 241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 241
gtctgctgat ctatctgttg 20
<210> 242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 242
attagtttat cttttttttc 20
<210> 243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 243
ctgtcagtag agagatttag 20
<210> 244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 244
tgcacatttc tgaatttctc 20
<210> 245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 245
gtaccagcta atccattcaa 20
<210> 246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 246
tgttctgtat aataatgtaa 20
<210> 247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 247
cgagagaccc atttactgca 20
<210> 248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 248
tgggctcata attatttttt 20
<210> 249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 249
aagtcatttt atgatcttgc 20
<210> 250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 250
atttacttgt atatttgtct 20
<210> 251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 251
gtttccatag cttccttttt 20
<210> 252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 252
tctcaaatag gtacactcaa 20
<210> 253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 253
ttttgtttaa agggttttac 20
<210> 254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 254
gtgtgacact atttggtttc 20
<210> 255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 255
attgttgctt ttctacttca 20
<210> 256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 256
aagtgggctt ttgatagtgt 20
<210> 257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 257
tgctgttgct ctggctgctg 20
<210> 258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 258
tctttctctc ttgttcctgg 20
<210> 259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 259
tcttttcacg aagattttgc 20
<210> 260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 260
aagtcacatt tgatttctgt 20
<210> 261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 261
tcttggttgg atttcatttt 20
<210> 262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 262
tgaggtgctg ctgctgctgc 20
<210> 263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 263
tggcctgctg cagccggctg 20
<210> 264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 264
ggttgaagtt ctcgctcttg 20
<210> 265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 265
tcttctgttt ttaagtcttc 20
<210> 266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 266
tggctggttc tctccggaca 20
<210> 267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 267
tgctgggttc tattttggtg 20
<210> 268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 268
atgtaaatac tgtgttattt 20
<210> 269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 269
ggttcctgat gttgattttg 20
<210> 270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 270
tgggtgttcg ctctctccct 20
<210> 271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 271
aaagcaactt agtttttttt 20
<210> 272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 272
gtagtacttg gtggtcattt 20
<210> 273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 273
tgctacattt atttatgctc 20
<210> 274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 274
tgttcagttt agttgcagcc 20
<210> 275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 275
aatactagac agccaaaatg 20
<210> 276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 276
aggtggtgtg tgtttttctg 20
<210> 277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 277
attattttat aattcctata 20
<210> 278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 278
tccaggctac atggctccag 20
<210> 279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 279
atttttttct tttcgccctg 20
<210> 280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 280
aggttcttgt ttgttggttt 20
<210> 281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 281
atagaggctc acaattccaa 20
<210> 282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 282
tgttgagctg cttgtggttc 20
<210> 283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 283
tgatgtgttc ttaaattctc 20
<210> 284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 284
ttttgttttc ttcagcttct 20
<210> 285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 285
ttctctgctt tttttttttt 20
<210> 286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 286
caagattata ttctttgggt 20
<210> 287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 287
tgctccgtat ttattctggc 20
<210> 288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 288
gttattgtat agatactacc 20
<210> 289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 289
gcactaacta aaggatttac 20
<210> 290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 290
aacccaagtt ctggtgtctg 20
<210> 291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 291
gtgcaagtac aatattttac 20
<210> 292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 292
attttattag tacgagtata 20
<210> 293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 293
gtgcttgtag tagtttttgt 20
<210> 294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 294
gttagtggag ggtgcttagt 20
<210> 295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 295
tcctgttatt ttggtactgg 20
<210> 296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 296
gtttgcctac tcctggtctg 20
<210> 297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 297
gttgactatc ttattttttc 20
<210> 298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 298
tcttgctttt aatttttttg 20
<210> 299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 299
gttcacctac atgtttcccc 20
<210> 300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 300
tctttttttt ttaattacag 20
<210> 301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 301
tggtgcactc agctctacct 20
<210> 302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 302
aaaaatcctg atcaaaaaaa 20
<210> 303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 303
ggctccatac tccattctgt 20
<210> 304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 304
tgtataatat tccattctgt 20
<210> 305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 305
attttattac atttttcttg 20
<210> 306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 306
tctatgttag tcatttctct 20
<210> 307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 307
tcttgacatg atgtttccct 20
<210> 308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 308
attaccttaa aactaccttg 20
<210> 309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 309
taagccatgc ctggacttcg 20
<210> 310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 310
gtttgcatta aatgactgtg 20
<210> 311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 311
tgtttgatat ttcttttttt 20
<210> 312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 312
tcttgggtaa ctagatgatg 20
<210> 313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 313
gttttttttt ttatttgcct 20
<210> 314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 314
gtcaggttat aatgaccctg 20
<210> 315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 315
tcttctgtat ttaattcttc 20
<210> 316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 316
gttattgtgt ttatattcag 20
<210> 317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 317
tggtgacatc ttgtttctac 20
<210> 318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 318
tgagccactg tgtgtagcca 20
<210> 319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 319
ttgtctgctg atctatctgt 20
<210> 320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 320
gttttttatt tttaaattag 20
<210> 321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 321
ccttgcactt ttgtttctac 20
<210> 322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 322
tcagtacatg ttcatcttaa 20
<210> 323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 323
cggcatgttc aatgttggca 20
<210> 324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 324
gtgagctatt atggtgtcac 20
<210> 325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 325
gtctgctttc ctggaaggct 20
<210> 326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 326
atccccctaa atcgactcct 20
<210> 327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 327
gttattttct ctccactctc 20
<210> 328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 328
attctttttt atttacttgt 20
<210> 329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 329
tctagtttcc atagcttcct 20
<210> 330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 330
tctttgtttc tttttgccta 20
<210> 331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 331
tccatttttg tttaaagggt 20
<210> 332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 332
tggtacagat aattgtgatg 20
<210> 333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 333
tggattttat acacattcag 20
<210> 334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 334
cttagatttt atgagctcaa 20
<210> 335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 335
gctgctgttg ctctggctgc 20
<210> 336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 336
ctctttctct cttgttcctg 20
<210> 337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 337
accataagct atcagttcct 20
<210> 338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 338
gtctggatgg ctctgatttt 20
<210> 339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 339
tccgctcttg gttggatttc 20
<210> 340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 340
tgctgaggtg ctgctgctgc 20
<210> 341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 341
gttcaggacc tccttggcct 20
<210> 342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 342
ctcagggttg aagttctcgc 20
<210> 343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 343
tgcactctgg atgaaatctt 20
<210> 344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 344
cttcaggttc ttgagggtaa 20
<210> 345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 345
gcttgctggg ttctattttg 20
<210> 346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 346
cctgctgtaa ctctaatgac 20
<210> 347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 347
tggttaactt tccaaatctg 20
<210> 348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 348
gttttcctaa cactgcacag 20
<210> 349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 349
atgtagttac agtgttgaaa 20
<210> 350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 350
caggtagtac ttggtggtca 20
<210> 351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 351
attttgctac atttatttat 20
<210> 352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 352
gtatttgttc agtttagttg 20
<210> 353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 353
gctattctaa acctattcaa 20
<210> 354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 354
ggtttagtgg atccagtcaa 20
<210> 355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 355
aagtgtttag aaagaaccaa 20
<210> 356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 356
tggcaggtgg tcccctccac 20
<210> 357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 357
atagtattat ttttttcttt 20
<210> 358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 358
agagaggttc ttgtttgttg 20
<210> 359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 359
tgctgccact tcctggtggg 20
<210> 360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 360
gtctgttgag ctgcttgtgg 20
<210> 361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 361
ctctgtatat ttattacttg 20
<210> 362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 362
attttgtttt cttcagcttc 20
<210> 363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 363
ccttctctgc tttttttttt 20
<210> 364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 364
gttcaagatt atattctttg 20
<210> 365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 365
gtccggcttg atttttggac 20
<210> 366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 366
ttgttgttat tgtatagata 20
<210> 367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 367
tttagagttg agcagttcag 20
<210> 368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 368
tgtcagtctg gtagtgccct 20
<210> 369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 369
attttttaat atttgtttaa 20
<210> 370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 370
gttattttat tagtacgagt 20
<210> 371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 371
ggtgcttgta gtagtttttg 20
<210> 372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 372
tcctcctttt atatctgttt 20
<210> 373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 373
gtttgattac tgtcatgact 20
<210> 374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 374
gtgaaaagaa agatgtactt 20
<210> 375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 375
cgttgactat cttatttttt 20
<210> 376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 376
tctcaattat aatttgtttt 20
<210> 377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 377
gtttccttaa aagcaactgt 20
<210> 378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 378
agagtcaatg attaaattca 20
<210> 379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 379
catgactctt tcttaagaat 20
<210> 380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 380
aaattttcta gaaacattaa 20
<210> 381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 381
gttaccattc tcctttcccc 20
<210> 382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 382
tgctagctac agagcactga 20
<210> 383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 383
cgttggatat tttattcttt 20
<210> 384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 384
atgtttgtat tccatatttg 20
<210> 385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 385
tcttttcatc ttcagctctg 20
<210> 386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 386
gtttgtgctt ttggtgtcac 20
<210> 387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 387
gtttgctttc ttcatcctac 20
<210> 388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 388
aatcgcaggg aggattgaaa 20
<210> 389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 389
tgacctttat ttggatcttg 20
<210> 390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 390
tggcatttat aatatttgtg 20
<210> 391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 391
attttcttag aaggatctct 20
<210> 392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 392
gtttgaactg agcatgtttt 20
<210> 393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 393
tggtcattag atcatgctac 20
<210> 394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 394
tgtagctttt agtgactttg 20
<210> 395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 395
attttggctt tccatagtgt 20
<210> 396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 396
gttactgctg ctgtgtgggc 20
<210> 397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 397
ctaggattag ctaattccta 20
<210> 398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 398
tctctactaa aatgtttttt 20
<210> 399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 399
ggagtatttt agctgtgatg 20
<210> 400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 400
gcttcctttg gtgcacgcag 20
<210> 401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 401
gtttgacata gtttctctgt 20
<210> 402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 402
tggtgtgtac ttgtggtccc 20
<210> 403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 403
gtttcagtaa gtatgtcttg 20
<210> 404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 404
gttataagag atctgcctac 20
<210> 405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 405
atcacacttc agttattttc 20
<210> 406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 406
tcttcttatg cattcttttt 20
<210> 407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 407
ccacccactg tccttttcag 20
<210> 408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 408
attcttcttt aatcacttca 20
<210> 409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 409
gtttgcttat tcttgcccaa 20
<210> 410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 410
tccatggtac agataattgt 20
<210> 411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 411
gttggattct ttttttcttt 20
<210> 412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 412
tctatagctg gtctctgtta 20
<210> 413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 413
cttgcggctg ctgttgctct 20
<210> 414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 414
actctttctc tcttgttcct 20
<210> 415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 415
gtaccatgtg ctttcatcac 20
<210> 416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 416
gtttcactgt ctggatggct 20
<210> 417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 417
tgctccgctc ttggttggat 20
<210> 418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 418
gtactggttc tgctgggctg 20
<210> 419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 419
gccggctctt ctccatctca 20
<210> 420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 420
ccttctttag ctccccgttg 20
<210> 421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 421
tgcttatctc tgcactctgg 20
<210> 422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 422
agagccgttc ttcaggttct 20
<210> 423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 423
gccgaccacc tcctcttcct 20
<210> 424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 424
tgcaccagtc tcctgcgaca 20
<210> 425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 425
tgttctttta aatggttaac 20
<210> 426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 426
gtttgcatct acctcttggg 20
<210> 427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 427
tgcagagctg aaatgtagtt 20
<210> 428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 428
cgtcaggtag tacttggtgg 20
<210> 429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 429
aatggcctag agtttaggca 20
<210> 430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 430
caggtatttg ttcagtttag 20
<210> 431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 431
tcctcttacc atcaaaggct 20
<210> 432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 432
tgttggttta gtggatccag 20
<210> 433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 433
tggcacagaa agtattgcac 20
<210> 434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 434
gtggtgaccg tgggtggcag 20
<210> 435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 435
gtttcttatt aatagtatta 20
<210> 436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 436
gtcattttat atatttagaa 20
<210> 437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 437
ggagggatgc tgccacttcc 20
<210> 438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 438
cagtctgttg agctgcttgt 20
<210> 439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 439
ttctctgtat atttattact 20
<210> 440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 440
cttcaaaatt ttgttttctt 20
<210> 441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 441
tgacaaattt ctatatacaa 20
<210> 442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 442
tgagtcctgt ttgattggta 20
<210> 443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 443
gtttccactg tccggcttga 20
<210> 444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 444
tcttagagat tgttgttatt 20
<210> 445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 445
atttgggttt agagttgagc 20
<210> 446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 446
tccctagttc tcctctgtac 20
<210> 447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 447
tccatttttt aatatttgtt 20
<210> 448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 448
ctgttatttt attagtacga 20
<210> 449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 449
tggtgcttgt agtagttttt 20
<210> 450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 450
tcttcatttt aatgttgttt 20
<210> 451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 451
tctgctctaa aactttctac 20
<210> 452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 452
ttattagtga aaagaaagat 20
<210> 453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 453
attcagatat aattgtttac 20
<210> 454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 454
gtgtgaataa ctaattcctt 20
<210> 455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 455
tgtttgataa atgttattct 20
<210> 456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 456
tattatatta aaagttaaaa 20
<210> 457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 457
agaggcttct ggaaatcccc 20
<210> 458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 458
cctgtcttga taaaataaaa 20
<210> 459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 459
tgcatctatt ttctattctg 20
<210> 460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 460
gaaaattcct actcattttt 20
<210> 461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 461
gtttctgcta atctgtgaca 20
<210> 462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 462
gtttgcagtt aacttttttt 20
<210> 463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 463
tggttattta ctcattctac 20
<210> 464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 464
tcttttcata agcttattgg 20
<210> 465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 465
gtctgctttc aatgaagcac 20
<210> 466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 466
actttcctgt cttacaagag 20
<210> 467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 467
gtgagaactg ctattttcag 20
<210> 468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 468
tcagctgtac agctccttac 20
<210> 469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 469
tggtcattat ctagtttctg 20
<210> 470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 470
gtgtgtctag tttgtttttc 20
<210> 471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 471
gttatatatt tcctattttc 20
<210> 472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 472
tctatatatt aatcatttcc 20
<210> 473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 473
gggttatatc atgttggcca 20
<210> 474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 474
cggtgtggtg tcccatccct 20
<210> 475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 475
ctttgatatt ttagtgtctt 20
<210> 476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 476
tcctgatttt cttttttttt 20
<210> 477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 477
tgctctctgt ctgagtctcc 20
<210> 478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 478
gtgccagttc ctgcattttc 20
<210> 479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 479
gtggtttgac atagtttctc 20
<210> 480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 480
gtttttctta cacatggtag 20
<210> 481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 481
ggtttcagta agtatgtctt 20
<210> 482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 482
tgtggttata agagatctgc 20
<210> 483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 483
tcatgatttt attgaatcac 20
<210> 484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 484
tctttatacc agggatcccc 20
<210> 485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 485
tcatactttc ttccgctctt 20
<210> 486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 486
gggtttcatt caccatgttg 20
<210> 487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 487
cggtttgctt attcttgccc 20
<210> 488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 488
attttctttt ttctgtgcct 20
<210> 489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 489
tgttggattc tttttttctt 20
<210> 490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 490
tgggttgtac ctctacttgc 20
<210> 491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 491
tggtgacttg atgcacgatg 20
<210> 492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 492
tccactcttt ctctcttgtt 20
<210> 493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 493
tctttcttcc tttcacagag 20
<210> 494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 494
gtgactgttt cactgtctgg 20
<210> 495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 495
cgttgctccg ctcttggttg 20
<210> 496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 496
ggtggcctcc cgagggacaa 20
<210> 497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 497
atcacgactg ctgtagtctg 20
<210> 498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 498
tccaccttct ttagctcccc 20
<210> 499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 499
cgttgcttat ctctgcactc 20
<210> 500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 500
gtgtctgctg cccgccaggc 20
<210> 501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 501
ttctgacttc tccagtttgc 20
<210> 502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 502
gtgcccttcc tcccgcccgc 20
<210> 503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 503
tttattgtaa aatatgttgg 20
<210> 504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 504
ggcagtttgc atctacctct 20
<210> 505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 505
cttgctcttc agcaattctg 20
<210> 506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 506
atgccttgaa ctgattctca 20
<210> 507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 507
ctcacatata taaatgtctt 20
<210> 508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 508
aaagtactat tttcaatggg 20
<210> 509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 509
cagcccgtat tcctcttacc 20
<210> 510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 510
gtgttggttt agtggatcca 20
<210> 511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 511
tggtcagact ctattggcac 20
<210> 512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 512
tgtttgctac acagaagcgg 20
<210> 513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 513
tggtttctta ttaatagtat 20
<210> 514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 514
cagtcatttt atatatttag 20
<210> 515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 515
gtgcaaagag tggattttat 20
<210> 516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 516
tggccctgtt ttcacctggt 20
<210> 517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 517
gtttggagtt tccctatgcc 20
<210> 518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 518
tgagtgcttc aaaattttgt 20
<210> 519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 519
gtagtaattc ttccaggcca 20
<210> 520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 520
tgtccccata atgagtcctg 20
<210> 521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 521
gtccagtttc cactgtccgg 20
<210> 522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 522
ggacagtatg ttatcttggt 20
<210> 523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 523
ggctgacact aatttgggtt 20
<210> 524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 524
ccttccctag ttctcctctg 20
<210> 525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 525
cttccatttt ttaatatttg 20
<210> 526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 526
cactgttatt ttattagtac 20
<210> 527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 527
ataaaagttg agtagctaga 20
<210> 528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 528
tccgcattat ttttccctgc 20
<210> 529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 529
tcctactttt aagtttccag 20
<210> 530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 530
aaactaattt attagtgaaa 20
<210> 531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 531
tgtatagtag aatttttttt 20
<210> 532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 532
gtgtgtttag ttgtttgggt 20
<210> 533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 533
gttgagactt aattgctcag 20
<210> 534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 534
gaatactatg tatttgccac 20
<210> 535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 535
ttttgacaag tcagtctttt 20
<210> 536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 536
gtttccttaa aatatgttgg 20
<210> 537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 537
tccattgtat atgtatctgt 20
<210> 538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 538
gttatattta atcatgttcc 20
<210> 539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 539
gtcatatttc ttagtttctg 20
<210> 540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 540
gttatgttta aggtattttc 20
<210> 541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 541
cgtcggataa atttatccac 20
<210> 542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 542
gttttctata gtgattgcac 20
<210> 543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 543
tctttttttc ttttaaccct 20
<210> 544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 544
caatcaggaa ctttcctgtc 20
<210> 545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 545
aggaacacaa gagggaatac 20
<210> 546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 546
tctttcctaa agcttattag 20
<210> 547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 547
gttttaactc agctctctct 20
<210> 548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 548
cggctagtat ttatattttt 20
<210> 549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 549
gtctacattt atagatttag 20
<210> 550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 550
gtgttacata aattaattcc 20
<210> 551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 551
gttactgttc ttatcttgtg 20
<210> 552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 552
ggtgagtttc tggattgtct 20
<210> 553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 553
gctttgatat tttagtgtct 20
<210> 554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 554
tgagctgtat tattatgcca 20
<210> 555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 555
tccagatatg agttctctct 20
<210> 556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 556
gttcagactc agatctcttc 20
<210> 557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 557
atagtcttta atttttttct 20
<210> 558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 558
gtggaagtgt ttcagggttg 20
<210> 559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 559
tgttgtttaa atatgtctcc 20
<210> 560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 560
gtgtggttat aagagatctg 20
<210> 561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 561
cagtgctttc tccagggtgt 20
<210> 562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 562
tcctctttat accagggatc 20
<210> 563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 563
atctccataa atggtatccc 20
<210> 564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 564
ggagagagag aatatttgag 20
<210> 565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 565
tgcggtttgc ttattcttgc 20
<210> 566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 566
acttgagtac attcatatgg 20
<210> 567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 567
atctagattg aagtttgtac 20
<210> 568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 568
tgaggctctt ctctttgggt 20
<210> 569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 569
attgctgtac aaggatgaca 20
<210> 570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 570
gcaggctgaa atccactctt 20
<210> 571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 571
tgttctttct tcctttcaca 20
<210> 572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 572
cggtgactgt ttcactgtct 20
<210> 573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 573
cggtggttgt cgctgggcag 20
<210> 574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 574
agctttcttg gtggcctccc 20
<210> 575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 575
gcttccctaa atgcaggcca 20
<210> 576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 576
tcttccacct tctttagctc 20
<210> 577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 577
gtcttcaatc ctctctacgg 20
<210> 578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 578
ctcggcatac ctgtgtctgc 20
<210> 579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 579
gtcttctgac ttctccagtt 20
<210> 580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 580
gctcctgctg tgcccttcct 20
<210> 581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 581
atacaattaa aagttgcttt 20
<210> 582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 582
acccgagttg tccatagtca 20
<210> 583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 583
ctttcaatat cttgctcttc 20
<210> 584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 584
cttttctctc agtttctctg 20
<210> 585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 585
gctcacatat ataaatgtct 20
<210> 586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 586
ttttttttta atttgtgaaa 20
<210> 587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 587
gtgtgttttt ctgagtccac 20
<210> 588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 588
atcttagtgt tggtttagtg 20
<210> 589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 589
tgagctttaa ctatatagca 20
<210> 590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 590
tggctgatcc ttgtaagctg 20
<210> 591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 591
tgttggtttc ttattaatag 20
<210> 592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 592
tcttaagtta aacattctaa 20
<210> 593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 593
ataggtttcc ttagtagtca 20
<210> 594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 594
tctgctggcc ctgttttcac 20
<210> 595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 595
tccggagtag aggtgtgcaa 20
<210> 596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 596
gtgagtgctt caaaattttg 20
<210> 597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 597
gtatagttta agagcctttt 20
<210> 598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 598
cattgaaatc atgtttttac 20
<210> 599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 599
cccacagctg tccagtttcc 20
<210> 600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 600
acttggtatt ctggaggaca 20
<210> 601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 601
gggtaatgat ctgatattaa 20
<210> 602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 602
atgcacttaa aattttcttt 20
<210> 603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 603
tcttccattt tttaatattt 20
<210> 604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 604
tggcactgtt attttattag 20
<210> 605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 605
tgctcattaa ataattgcag 20
<210> 606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 606
gtgtcactag aagatgccca 20
<210> 607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 607
gtgctcacta ataatagtct 20
<210> 608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 608
tctcctctac ttaagctcag 20
<210> 609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 609
gtttcctatc ctgattccca 20
<210> 610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 610
gtttgtgtgt ttagttgttt 20
<210> 611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 611
gtgaccactc tcctcctccc 20
<210> 612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 612
aaggttttct cttaaatatt 20
<210> 613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 613
tccgaagctg ctatatgtca 20
<210> 614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 614
gtgtgacact attattcttt 20
<210> 615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 615
cgacctttaa aattttttca 20
<210> 616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 616
atttgtttac ttctatattg 20
<210> 617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 617
gcttctttaa atcttagctc 20
<210> 618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 618
gtttgagtcc agtgacttct 20
<210> 619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 619
tcttgagttt atcttttctt 20
<210> 620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 620
ctccagtgca gggctggact 20
<210> 621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 621
gtttgggttt ttctgtacaa 20
<210> 622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 622
tggtaggtat atagatgtcc 20
<210> 623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 623
atcccaataa aaacattcag 20
<210> 624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 624
tgttccatag ctcatttgca 20
<210> 625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 625
tgctgtgtac ttaattgaca 20
<210> 626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 626
tcttgtctag ttttctgcag 20
<210> 627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 627
gtcatttttg aacatatcct 20
<210> 628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 628
gtctgtgtac ctcattcttt 20
<210> 629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 629
gtgtgggtgg ctgtgtcctg 20
<210> 630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 630
tggtgagttt ctggattgtc 20
<210> 631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 631
cttttatttt ctgatgcttt 20
<210> 632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 632
gtagttcatt ttctttctcc 20
<210> 633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 633
aagtccagat atgagttctc 20
<210> 634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 634
atgttcagac tcagatctct 20
<210> 635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 635
aatagtcttt aatttttttc 20
<210> 636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 636
tccttggtgg aagtgtttca 20
<210> 637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 637
ctgttgttta aatatgtctc 20
<210> 638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 638
tcctccactc tttccctccc 20
<210> 639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 639
gtttgccttc tgtatggaaa 20
<210> 640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 640
tggagccttg ctatgttggc 20
<210> 641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 641
tggttaagac ctagtttctt 20
<210> 642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 642
atttcttgag atggattctc 20
<210> 643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 643
tctaccagag ttgcggtttg 20
<210> 644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 644
cttcatcttc tttgtttcct 20
<210> 645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 645
cattcttttg agttgtgacc 20
<210> 646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 646
gtttgatttt atgcacacac 20
<210> 647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 647
agaccaaaaa ccatttgtgt 20
<210> 648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 648
actctggatg aaatcttctg 20
<210> 649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 649
gctgggttct attttggtga 20
<210> 650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 650
ttttattgta aaatatgttg 20
<210> 651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 651
gatagtaata tatgctcatc 20
<210> 652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 652
ttggtggtca tttattgtca 20
<210> 653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 653
atcttgctca catatataaa 20
<210> 654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 654
ctagacagcc aaaatgtggg 20
<210> 655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 655
ccagtcaatt caatactcga 20
<210> 656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 656
ctccacattc actattccgt 20
<210> 657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 657
ttcttaagtt aaacattcta 20
<210> 658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 658
ggagtaatcc acaagatgca 20
<210> 659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 659
tcctttcaca tcaccaccga 20
<210> 660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 660
atgtaaaaga aatctcagct 20
<210> 661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 661
acatgacaaa tttctatata 20
<210> 662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 662
gtttttactc cccccattta 20
<210> 663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 663
tgcacttaat tttaatacag 20
<210> 664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 664
gggcagtatt cacagaactg 20
<210> 665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 665
tcttaactat tatgtatgca 20
<210> 666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 666
tcaaattttg aatcaaacat 20
<210> 667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 667
tgagtgcaca tttaatcttt 20
<210> 668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 668
ttgtcatatt tttatagcat 20
<210> 669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 669
tgttcattcc cttagtaact 20
<210> 670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 670
ggcaagatct tttaaagtcc 20
<210> 671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 671
agactgtttc tttaccacat 20
<210> 672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 672
tccaccagta tttatggagt 20
<210> 673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 673
ctttagtatt tttatcatta 20
<210> 674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 674
aacagtacaa tttacttgac 20
<210> 675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 675
cctttaaaaa ccaacacagt 20
<210> 676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 676
tcttgtcatt tttaacatcc 20
<210> 677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 677
actcaatttt aaagactcgg 20
<210> 678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 678
atgtgttgaa tttaaccagc 20
<210> 679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 679
ctcattaatt aaatcattcg 20
<210> 680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 680
cacctaaaaa tacaggaagt 20
<210> 681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 681
ccaagaattt aaaaaggaca 20
<210> 682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 682
tgtctcaaac tattcccatt 20
<210> 683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 683
ttaacaatct tttagacctg 20
<210> 684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 684
gacatatttc aaaaatgcaa 20
<210> 685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 685
aacttgtttc aaagtgagag 20
<210> 686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 686
tcagggttcc tcatcttaat 20
<210> 687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 687
agagagtata aaaattatct 20
<210> 688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 688
gcagcctcct atattggtcc 20
<210> 689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 689
ccagtgactc atcttggcta 20
<210> 690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 690
tggtcctttc ctcacttggg 20
<210> 691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 691
catgtttatt ttccatgtgt 20
<210> 692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 692
acacacctag atcttcctcc 20
<210> 693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 693
cagcagtgcc taaccagttg 20
<210> 694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 694
tgccagagac ccaaatccgc 20
<210> 695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 695
tcatccccaa actaaacacc 20
<210> 696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 696
gctaacctac ttcctaccca 20
<210> 697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 697
catgacatca tttagcctta 20
<210> 698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 698
ggccctaata acacagagcc 20
<210> 699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 699
gcggcacaaa tccagggctg 20
<210> 700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 700
gtagtataaa ctatggactt 20
<210> 701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 701
agggttgttc agtaaaccca 20
<210> 702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 702
gctaggtttc agtaagtatg 20
<210> 703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 703
acacgcatat ttatgctgtt 20
<210> 704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 704
acctccaact cccattttgg 20
<210> 705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 705
gtaaatatat cctgtttcaa 20
<210> 706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 706
tcaccttgtc agatgctgag 20
<210> 707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 707
ggtgagcaac cattccagac 20
<210> 708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 708
ctcggtcacc acatgcaagc 20
<210> 709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 709
gacctaaaac acaccagacc 20
<210> 710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 710
atagcttcaa aatattgtta 20
<210> 711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 711
atctttattt tataattagg 20
<210> 712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 712
gatgccacga ccagatatca 20
<210> 713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 713
accaaactcc aaatctccaa 20
<210> 714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 714
tcaaccttct tgaaccctca 20
<210> 715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 715
tcattatttc cgcatctcaa 20
<210> 716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 716
ccggacacct acccatggag 20
<210> 717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 717
cactgtattc taagtaggag 20
<210> 718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 718
gcctcctgac ctctaccctt 20
<210> 719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 719
agtagatttc cacagattgt 20
<210> 720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 720
agcctctaga acaaaataca 20
<210> 721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 721
agcttgagaa ttttgatagg 20
<210> 722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 722
gaaccacaag ccaacaggcc 20
<210> 723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 723
actgtgagtt ccaagaagca 20
<210> 724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 724
tgggtacaat ccgccaacag 20
<210> 725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 725
tgtcttcaat cctctctacg 20
<210> 726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 726
aggaagagtc aaaggtggtt 20
<210> 727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 727
gttgctttta ttgtaaaata 20
<210> 728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 728
aagatagtaa tatatgctca 20
<210> 729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 729
catcaaagtg aaaagtgcct 20
<210> 730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 730
ccattctgaa aataacatta 20
<210> 731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 731
ggtgaaccct aaatgtaaat 20
<210> 732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 732
tccagtcaat tcaatactcg 20
<210> 733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 733
acactccaca ttcactattc 20
<210> 734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 734
actgaaataa ttcttaagtt 20
<210> 735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 735
agcattatat tgcaatctat 20
<210> 736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 736
tctcctttca catcaccacc 20
<210> 737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 737
gaggtcatct atgtaaaaga 20
<210> 738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 738
gacatgacaa atttctatat 20
<210> 739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 739
atcatgtttt tactcccccc 20
<210> 740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 740
cctattggcc aaatgcactt 20
<210> 741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 741
tcttgaaacc tcctttcggc 20
<210> 742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 742
ctcttaacta ttatgtatgc 20
<210> 743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 743
gttcaaattt tgaatcaaac 20
<210> 744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 744
cccaaatttc aaaggtcctt 20
<210> 745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 745
gtggtcaaag aatctgtttc 20
<210> 746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 746
tagaaactaa tttattagtg 20
<210> 747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 747
acacagatta tttatagtca 20
<210> 748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 748
cactttctag attattctta 20
<210> 749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 749
actctctacc tttaagattt 20
<210> 750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 750
catctattta tttaccttct 20
<210> 751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 751
gaacttaaaa ttccctagga 20
<210> 752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 752
tcttttaacc tttaaaaacc 20
<210> 753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 753
acctgctttc aaaagtcaaa 20
<210> 754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 754
caagtaatac aaatccacag 20
<210> 755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 755
caggacttat tttatatatg 20
<210> 756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 756
cttcccaaat acatcatcga 20
<210> 757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 757
catttaaaaa ctgtacatgg 20
<210> 758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 758
atctaaattt aaactgcaca 20
<210> 759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 759
tggtcaataa tttatatggc 20
<210> 760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 760
aactattata tttatagatt 20
<210> 761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 761
agctgtaaaa tatatccctg 20
<210> 762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 762
aaccttactt aaatatctca 20
<210> 763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 763
atcagggttc ctcatcttaa 20
<210> 764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 764
gtgccctttc ctcttgggat 20
<210> 765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 765
cccagcagcc tcctatattg 20
<210> 766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 766
acttccagtg actcatcttg 20
<210> 767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 767
atttggtcct ttcctcactt 20
<210> 768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 768
ctcatgttta ttttccatgt 20
<210> 769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 769
agggaaaaac acacctagat 20
<210> 770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 770
gtcagcagtg cctaaccagt 20
<210> 771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 771
acagaaaaac aaaactcatt 20
<210> 772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 772
ccttaaaaat catccccaaa 20
<210> 773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 773
cagctaacct acttcctacc 20
<210> 774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 774
tcagaaatac agattgatat 20
<210> 775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 775
acggccctaa taacacagag 20
<210> 776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 776
actgcggcac aaatccaggg 20
<210> 777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 777
tgtagtataa actatggact 20
<210> 778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 778
gaagtgtttc agggttgttc 20
<210> 779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 779
agctaggttt cagtaagtat 20
<210> 780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 780
tacacgcata tttatgctgt 20
<210> 781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 781
aactgtcacc tccaactccc 20
<210> 782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 782
ccagtaaata tatcctgttt 20
<210> 783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 783
catagccacc tcaccttgtc 20
<210> 784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 784
gcaacagacc agtagcagtc 20
<210> 785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 785
tacctccacc acctttgtcc 20
<210> 786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 786
gtgacctaaa acacaccaga 20
<210> 787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 787
gatagcttca aaatattgtt 20
<210> 788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 788
gcaaatctat ctttatttta 20
<210> 789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 789
cctgcgaaaa gatgccacga 20
<210> 790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 790
aagttcagtt acagaggtgc 20
<210> 791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 791
gttctcaacc ttcttgaacc 20
<210> 792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 792
ctttcattat ttccgcatct 20
<210> 793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 793
gccggacacc tacccatgga 20
<210> 794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 794
cccactgtat tctaagtagg 20
<210> 795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 795
tttttctgtg cctcctgacc 20
<210> 796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 796
aagtaccaaa aaaactttaa 20
<210> 797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 797
agcctctaga acaggctggg 20
<210> 798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 798
acagcttgag aattttgata 20
<210> 799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 799
acagtgaacc acaagccaac 20
<210> 800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 800
acaggactaa acatggatca 20
<210> 801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 801
atccaggctc ttcatgagga 20
<210> 802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 802
tatggctgtc ttcaatcctc 20
<210> 803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 803
caaatcttaa cctcctgagg 20
<210> 804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 804
tatacaatta aaagttgctt 20
<210> 805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 805
cagtattttt aaatgcttaa 20
<210> 806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 806
actgattctc agacatcaaa 20
<210> 807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 807
gccattctga aaataacatt 20
<210> 808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 808
ctggtgaacc ctaaatgtaa 20
<210> 809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 809
atccagtcaa ttcaatactc 20
<210> 810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 810
ccacactcca cattcactat 20
<210> 811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 811
cccctctgcc ccagtgtggc 20
<210> 812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 812
tgcagcatta tattgcaatc 20
<210> 813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 813
ctctcctttc acatcaccac 20
<210> 814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 814
tcctatcatc agtaaggtaa 20
<210> 815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 815
aatctgatca tttagacatg 20
<210> 816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 816
aatcatgttt ttactccccc 20
<210> 817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 817
atagatacta cctattggcc 20
<210> 818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 818
atcttgaaac ctcctttcgg 20
<210> 819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 819
agctcttaac tattatgtat 20
<210> 820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 820
gtatacagac aatttattta 20
<210> 821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 821
acatggtatt tttatcagtc 20
<210> 822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 822
cctaacaaaa tttcccttca 20
<210> 823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 823
gtgaattttc cttaaatttc 20
<210> 824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 824
tgcaaattct aaaaattact 20
<210> 825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 825
ttcttgtttc aaagtgagga 20
<210> 826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 826
gacctcatcc attataatat 20
<210> 827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 827
ccaaccaacc aaaaactcac 20
<210> 828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 828
catagttata tttaatcatg 20
<210> 829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 829
atgcctcacc tttaaatagt 20
<210> 830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 830
gacaagttta tttatttttc 20
<210> 831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 831
aactgatttc aaagtcagac 20
<210> 832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 832
actgaaactt tttaacatac 20
<210> 833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 833
cagcaaatac aaacaggacc 20
<210> 834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 834
acacagttac aaatcaatgc 20
<210> 835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 835
tggatctaaa tttaaactgc 20
<210> 836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 836
atgctcaaac ctcattcatt 20
<210> 837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 837
tactccttat tttaaatata 20
<210> 838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 838
aaggttctat tttatatgcc 20
<210> 839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 839
agtgttagag aatacttttc 20
<210> 840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 840
aatcagggtt cctcatctta 20
<210> 841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 841
tgccccccac tttacggtgt 20
<210> 842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 842
cagtccagag cccactcccc 20
<210> 843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 843
aaccatactt ccagtgactc 20
<210> 844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 844
ccagtcattc acgagtggtt 20
<210> 845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 845
tgactcttca ctcatgttta 20
<210> 846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 846
gtagggaaaa acacacctag 20
<210> 847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 847
catttctgaa tttctctgtg 20
<210> 848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 848
ccacagaaaa acaaaactca 20
<210> 849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 849
cccttaaaaa tcatccccaa 20
<210> 850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 850
gcagctaacc tacttcctac 20
<210> 851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 851
tactcagaaa tacagattga 20
<210> 852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 852
acagacggcc ctaataacac 20
<210> 853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 853
tgtattacca acaactgcgg 20
<210> 854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 854
acagagtgaa ctgtagtata 20
<210> 855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 855
agcctgactc agtccttggt 20
<210> 856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 856
gaattctctc ataagctagg 20
<210> 857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 857
atgcacatac acgcatattt 20
<210> 858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 858
ccatccccct aaatcgactc 20
<210> 859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 859
atccagtaaa tatatcctgt 20
<210> 860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 860
ggcagctttc tcagcggagc 20
<210> 861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 861
atccccaacc cccaggcaac 20
<210> 862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 862
actacctcca ccacctttgt 20
<210> 863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 863
aagtgaccta aaacacacca 20
<210> 864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 864
tgatagcttc aaaatattgt 20
<210> 865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 865
tagcaaatct atctttattt 20
<210> 866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 866
aggagctgtg tcaccctgcg 20
<210> 867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 867
cagccaaacc taagttcagt 20
<210> 868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 868
agttctcaac cttcttgaac 20
<210> 869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 869
aaagcctttc attatttccg 20
<210> 870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 870
ccggataact ccctgtctcc 20
<210> 871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 871
acccactgta ttctaagtag 20
<210> 872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 872
aacccatttt cttttttctg 20
<210> 873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 873
gattttatac acattcagac 20
<210> 874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 874
catcttgtaa actaaacagg 20
<210> 875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 875
gcttacaata attaagaaga 20
<210> 876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 876
agacagtgaa ccacaagcca 20
<210> 877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 877
ggacaggact aaacatggat 20
<210> 878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 878
agtctgataa acggaaagtc 20
<210> 879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 879
tatcacggcc acgcccgggc 20
<210> 880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 880
atgcaaatct taacctcctg 20
<210> 881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 881
ctatacaatt aaaagttgct 20
<210> 882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 882
acagtatttt taaatgctta 20
<210> 883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 883
aactgattct cagacatcaa 20
<210> 884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 884
gatttgattt tgaatagaaa 20
<210> 885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 885
cctggtgaac cctaaatgta 20
<210> 886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 886
tagtggatcc agtcaattca 20
<210> 887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 887
tctccacact ccacattcac 20
<210> 888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 888
cactttaaaa gatctgaggt 20
<210> 889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 889
gctactgttc atcttgaaca 20
<210> 890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 890
agtgtaattc tctcctttca 20
<210> 891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 891
aagaaaagat cctatcatca 20
<210> 892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 892
atacaaatct gatcatttag 20
<210> 893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 893
aaatcatgtt tttactcccc 20
<210> 894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 894
gtatagatac tacctattgg 20
<210> 895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 895
ccacaaatac tgacaggact 20
<210> 896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 896
aagctcttaa ctattatgta 20
<210> 897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 897
tggtatacag acaatttatt 20
<210> 898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 898
aactttaaaa ccaaagagcc 20
<210> 899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 899
tgtacaataa tatatttctt 20
<210> 900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 900
gcagaaattc attaaaaagg 20
<210> 901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 901
tactggtata tttatttgtt 20
<210> 902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 902
cttgagtttc attatctcct 20
<210> 903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 903
catacattcc cttaagccaa 20
<210> 904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 904
agtattattt aaaactacat 20
<210> 905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 905
ccatggtttc aaagctctgt 20
<210> 906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 906
agctataaaa tataaacttc 20
<210> 907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 907
agcttttgaa tttattatga 20
<210> 908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 908
cagagactat tttaaagacg 20
<210> 909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 909
ctcttatttt aaactggtgc 20
<210> 910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 910
ttactgatta tttaaccctg 20
<210> 911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 911
agttcatttt aaactgtatt 20
<210> 912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 912
tgtattattt tctaacagaa 20
<210> 913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 913
aagtatacaa tttaaggatc 20
<210> 914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 914
attagatttc cttactgcaa 20
<210> 915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 915
cctctcaaaa ccacttttat 20
<210> 916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 916
ccctcaattc aaagacaaat 20
<210> 917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 917
tttcctaatc agggttcctc 20
<210> 918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 918
gtgcccccca ctttacggtg 20
<210> 919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 919
cctgactttc atatgcaaac 20
<210> 920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 920
ttaaccatac ttccagtgac 20
<210> 921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 921
ccccatatcc agtcattcac 20
<210> 922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 922
gcaatgactc ttcactcatg 20
<210> 923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 923
gagtagggaa aaacacacct 20
<210> 924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 924
aagctcaaca atttgcacat 20
<210> 925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 925
acgaacacaa aaacccacag 20
<210> 926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 926
ccccttaaaa atcatcccca 20
<210> 927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 927
agcagctaac ctacttccta 20
<210> 928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 928
tcatactcag aaatacagat 20
<210> 929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 929
ttaagcagcc accgagtcag 20
<210> 930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 930
gtgtattacc aacaactgcg 20
<210> 931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 931
ttcatcaaaa acagcatgta 20
<210> 932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 932
cacgcaaagc ctgactcagt 20
<210> 933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 933
tgaattctct cataagctag 20
<210> 934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 934
actatgcaca tacacgcata 20
<210> 935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 935
atccatcccc ctaaatcgac 20
<210> 936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 936
catccagtaa atatatcctg 20
<210> 937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 937
ctttaccgcc taacaggcag 20
<210> 938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 938
gatccccaac ccccaggcaa 20
<210> 939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 939
ttttactacc tccaccacct 20
<210> 940
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 940
actcaaactt aaagtgacct 20
<210> 941
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 941
tgggtattct ctatgatgct 20
<210> 942
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 942
tcatagcaaa tctatcttta 20
<210> 943
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 943
gcttcctacc aaaggagctg 20
<210> 944
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 944
gcagccaaac ctaagttcag 20
<210> 945
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 945
aagaagttct caaccttctt 20
<210> 946
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 946
gaaagccttt cattatttcc 20
<210> 947
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 947
tagttccaaa catgtcagcc 20
<210> 948
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 948
gacaaatata cttacaagtg 20
<210> 949
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 949
cccccaaacc cattttcttt 20
<210> 950
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 950
ttggatttta tacacattca 20
<210> 951
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 951
gctataaatc aaagacatct 20
<210> 952
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 952
tgcttacaat aattaagaag 20
<210> 953
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 953
ttgtgacccc aaagcactgt 20
<210> 954
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 954
gctattatca tacaggacag 20
<210> 955
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 955
gattttagtc tgataaacgg 20
<210> 956
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 956
cgacggcgaa ctgtatcacg 20
<210> 957
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 957
tagaccggcc ttcaatgcaa 20
<210> 958
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 958
atctatacaa ttaaaagttg 20
<210> 959
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 959
gaacagtatt tttaaatgct 20
<210> 960
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 960
gaactgattc tcagacatca 20
<210> 961
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 961
accaaacatt aaatctcgat 20
<210> 962
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 962
gtttataaaa atcattagtc 20
<210> 963
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 963
gctccaaacc atgtgtgttt 20
<210> 964
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 964
gcctccttcc tctccacact 20
<210> 965
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 965
ttccacttta aaagatctga 20
<210> 966
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 966
ggattttatg attactagga 20
<210> 967
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 967
ggcctccacg ccacttaaaa 20
<210> 968
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 968
tgctacaaga aaagatccta 20
<210> 969
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 969
ataaccatac aaatctgatc 20
<210> 970
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 970
ttacattgaa atcatgtttt 20
<210> 971
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 971
tgtatagata ctacctattg 20
<210> 972
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 972
ggtcaccaca aatactgaca 20
<210> 973
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 973
tgtcacaata aaagctctta 20
<210> 974
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 974
actggtatac agacaattta 20
<210> 975
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 975
cccagcaaag ccatccagtg 20
<210> 976
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 976
ttgattacaa tttaaattca 20
<210> 977
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 977
aagggaatat tttactttat 20
<210> 978
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 978
ctattattat tttactggca 20
<210> 979
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 979
ttttatagcc actaaccaac 20
<210> 980
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 980
aacatatttc attataattc 20
<210> 981
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 981
acccagcatt tttaacatta 20
<210> 982
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 982
ctttcattta tttagtgaaa 20
<210> 983
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 983
ttccttactt tttaggatac 20
<210> 984
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 984
gatttatttt aaagtactct 20
<210> 985
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 985
gattccaaaa ccagacttgt 20
<210> 986
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 986
ccatatatag attacaaagc 20
<210> 987
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 987
tcttttaacc ctaagactgt 20
<210> 988
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 988
tgacagtatt tttaaagact 20
<210> 989
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 989
actggcaaac ccaaaagcta 20
<210> 990
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 990
actgttaaaa cccatccaac 20
<210> 991
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 991
atgcagttct aaaagaaagc 20
<210> 992
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 992
aggcccaaac ctctaatcaa 20
<210> 993
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 993
aagattcaaa tatatcttaa 20
<210> 994
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 994
ggacctgaag tccagcagcg 20
<210> 995
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 995
actccctcca cctcctgacc 20
<210> 996
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 996
gcctgacttt catatgcaaa 20
<210> 997
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 997
gcctgtggaa attaagagcg 20
<210> 998
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 998
tgcaagcccc catatccagt 20
<210> 999
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 999
ttaaggattc taagtaccat 20
<210> 1000
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1000
tcattaattt tgcaaagttt 20
<210> 1001
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1001
ttttgcttat taagctcaac 20
<210> 1002
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1002
aacgaacaca aaaacccaca 20
<210> 1003
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1003
agccccttaa aaatcatccc 20
<210> 1004
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1004
aagcagctaa cctacttcct 20
<210> 1005
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1005
gttcatactc agaaatacag 20
<210> 1006
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1006
cactgaatat taagcagcca 20
<210> 1007
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1007
tgtgtattac caacaactgc 20
<210> 1008
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1008
acatgacatc ataaattcat 20
<210> 1009
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1009
aatcatgttc acgcaaagcc 20
<210> 1010
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1010
aatgaattct ctcataagct 20
<210> 1011
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1011
ctatatctaa acactatgca 20
<210> 1012
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1012
catccatccc cctaaatcga 20
<210> 1013
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1013
tcatccagta aatatatcct 20
<210> 1014
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1014
gctttaccgc ctaacaggca 20
<210> 1015
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1015
cctctttata ccagggatcc 20
<210> 1016
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1016
tttttactac ctccaccacc 20
<210> 1017
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1017
gcaactcaaa cttaaagtga 20
<210> 1018
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1018
atgggtattc tctatgatgc 20
<210> 1019
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1019
attcatagca aatctatctt 20
<210> 1020
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1020
tgcttcctac caaaggagct 20
<210> 1021
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1021
agcagccaaa cctaagttca 20
<210> 1022
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1022
accctctatt aaaaatacta 20
<210> 1023
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1023
tttgaaagcc tttcattatt 20
<210> 1024
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1024
ccttagttcc aaacatgtca 20
<210> 1025
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1025
acatagacaa atatacttac 20
<210> 1026
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1026
gcccccaaac ccattttctt 20
<210> 1027
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1027
atgcaccacc accaccacgc 20
<210> 1028
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1028
tgctataaat caaagacatc 20
<210> 1029
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1029
ttacaaagac tatgcttaca 20
<210> 1030
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1030
agttgtgacc ccaaagcact 20
<210> 1031
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1031
tgctattatc atacaggaca 20
<210> 1032
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1032
tggctctgat tttagtctga 20
<210> 1033
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1033
tactctacca aaacttcaac 20
<210> 1034
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1034
ttagaccggc cttcaatgca 20
<210> 1035
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1035
gcagaaatga aatcccgcat 20
<210> 1036
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1036
tgagatacag tacttgttga 20
<210> 1037
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1037
ttctccatcc cttttctctc 20
<210> 1038
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1038
gtaccaaaca ttaaatctcg 20
<210> 1039
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1039
cggtttataa aaatcattag 20
<210> 1040
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1040
tgctccaaac catgtgtgtt 20
<210> 1041
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1041
tgaatctgcc tccttcctct 20
<210> 1042
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1042
tttccacttt aaaagatctg 20
<210> 1043
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1043
agtggatttt atgattacta 20
<210> 1044
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1044
ggttaaaaac aaatgtggaa 20
<210> 1045
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1045
gcttctcaaa tcaggtgtac 20
<210> 1046
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1046
ggccataacc atacaaatct 20
<210> 1047
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1047
ggcctcttta tattaaataa 20
<210> 1048
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1048
tcagataaga aaagttatgg 20
<210> 1049
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1049
aggtcaccac aaatactgac 20
<210> 1050
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1050
ttctcctgtc acaataaaag 20
<210> 1051
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1051
gtactggtat acagacaatt 20
<210> 1052
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1052
gtcctcaaaa cctatggagc 20
<210> 1053
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1053
tggcttaacc agggagatgt 20
<210> 1054
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1054
actgataatt tttagacata 20
<210> 1055
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1055
acctcaatca tttactctct 20
<210> 1056
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1056
actcctaaaa tttattgagg 20
<210> 1057
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1057
ccctgaatag tctatgccat 20
<210> 1058
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1058
ttccttaaaa tatgttggca 20
<210> 1059
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1059
ggaaacaacc aaaaactgct 20
<210> 1060
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1060
tgacacaata tttactgtgt 20
<210> 1061
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1061
tctcagtttc aaaataggac 20
<210> 1062
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1062
cctcaaaaag aatctgcaga 20
<210> 1063
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1063
tcggttacta tttacctttc 20
<210> 1064
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1064
ggaccctaaa tttaaacagc 20
<210> 1065
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1065
tggaaatttc aaaaagctaa 20
<210> 1066
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1066
aacaacaaat aattacctat 20
<210> 1067
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1067
aaggaaaatc aaacattgct 20
<210> 1068
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1068
aggtctagta tttatcttct 20
<210> 1069
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1069
gaaacattat tttacttttc 20
<210> 1070
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1070
tcctaaaaat acatcttaaa 20
<210> 1071
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1071
ctggtaagaa aaagtgccga 20
<210> 1072
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1072
gccacatttc ccctcactcc 20
<210> 1073
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1073
agcctgactt tcatatgcaa 20
<210> 1074
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1074
gtaatcgatc taagaacctg 20
<210> 1075
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1075
tttgtgcaag cccccatatc 20
<210> 1076
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1076
tgttcacaaa aatgtgttaa 20
<210> 1077
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1077
catttaatca ttaattttgc 20
<210> 1078
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1078
attttgctta ttaagctcaa 20
<210> 1079
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1079
ccaatgatcc catcactgca 20
<210> 1080
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1080
cagcccctta aaaatcatcc 20
<210> 1081
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1081
tgccagttcc tgcattttcc 20
<210> 1082
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1082
cagttcatac tcagaaatac 20
<210> 1083
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1083
gcactgaata ttaagcagcc 20
<210> 1084
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1084
gtgtgtatta ccaacaactg 20
<210> 1085
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1085
tacatgacat cataaattca 20
<210> 1086
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1086
acactgaatc atgttcacgc 20
<210> 1087
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1087
gagcaatgaa ttctctcata 20
<210> 1088
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1088
tactatatct aaacactatg 20
<210> 1089
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1089
tcctccatcc atccccctaa 20
<210> 1090
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1090
cccatttttt catccagtaa 20
<210> 1091
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1091
ggctttaccg cctaacaggc 20
<210> 1092
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1092
ctcctcttta taccagggat 20
<210> 1093
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1093
ttttttacta cctccaccac 20
<210> 1094
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1094
tgggcaactc aaacttaaag 20
<210> 1095
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1095
aatttaaaac ccatatgggt 20
<210> 1096
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1096
cacacatctc aaataggtac 20
<210> 1097
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1097
gcctaaattc tgcctttgct 20
<210> 1098
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1098
gtgagcagcc aaacctaagt 20
<210> 1099
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1099
aaccctctat taaaaatact 20
<210> 1100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1100
ctaaagactt cataatgtta 20
<210> 1101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1101
agccttagtt ccaaacatgt 20
<210> 1102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1102
gtgcatatat acatagacaa 20
<210> 1103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1103
ggcccccaaa cccattttct 20
<210> 1104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1104
aatatttaaa atattgttgg 20
<210> 1105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1105
ctgctataaa tcaaagacat 20
<210> 1106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1106
tagactttac aaagactatg 20
<210> 1107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1107
ctggtgagcc ccattctttt 20
<210> 1108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1108
ctgctattat catacaggac 20
<210> 1109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1109
gttggatttc atttttcgcc 20
<210> 1110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1110
atactctacc aaaacttcaa 20
<210> 1111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1111
ccacgctgcc tctacttgcc 20
<210> 1112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1112
agcagaaatg aaatcccgca 20
<210> 1113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1113
agtgagatac agtacttgtt 20
<210> 1114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1114
actggacaaa aatgagtatt 20
<210> 1115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1115
tgtaccaaac attaaatctc 20
<210> 1116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1116
acggtttata aaaatcatta 20
<210> 1117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1117
ttgctccaaa ccatgtgtgt 20
<210> 1118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1118
ccacacttcc cgtccaggct 20
<210> 1119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1119
ccaacataga aaattatcct 20
<210> 1120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1120
aagagtggat tttatgatta 20
<210> 1121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1121
gggttaaaaa caaatgtgga 20
<210> 1122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1122
agcttctcaa atcaggtgta 20
<210> 1123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1123
cttccaggcc ataaccatac 20
<210> 1124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1124
ctggcctctt tatattaaat 20
<210> 1125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1125
gagtcctttc agataagaaa 20
<210> 1126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1126
ctctggagcc aggactccac 20
<210> 1127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1127
catatggaaa aaagttctcc 20
<210> 1128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1128
tgtactggta tacagacaat 20
<210> 1129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1129
ccaataaaag ccacaacttg 20
<210> 1130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1130
aaggtgtata tttatatgtt 20
<210> 1131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1131
gctcaaattc aaaagatgaa 20
<210> 1132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1132
tcagtaaaac ctcaatcatt 20
<210> 1133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1133
tggaatattc tttattttgg 20
<210> 1134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1134
ttactctttc aaatgcaaaa 20
<210> 1135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1135
aggttctata tttagaacac 20
<210> 1136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1136
ctcacaattc aaaagttgtg 20
<210> 1137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1137
ttagtcaaac atatcaacct 20
<210> 1138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1138
ggctgcaaac tattcaagta 20
<210> 1139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1139
tcattattag attaccaaga 20
<210> 1140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1140
cagtaatttc aaaagggcca 20
<210> 1141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1141
tggatgctat tttatgtaga 20
<210> 1142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1142
gaccacaaaa cccaacttac 20
<210> 1143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1143
tcaacaaatc aaatactgat 20
<210> 1144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1144
tgctgcatat tttatattta 20
<210> 1145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1145
agtgtattag attaggtcta 20
<210> 1146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1146
ctccttaaac cccattttat 20
<210> 1147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1147
ctcctaaaaa tacatcttaa 20
<210> 1148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1148
cctggtaaga aaaagtgccg 20
<210> 1149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1149
gtttgccaca tttcccctca 20
<210> 1150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1150
cagagctaat tcctaggagc 20
<210> 1151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1151
gcatgtaatc gatctaagaa 20
<210> 1152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1152
ttcagggcta aaagctctcg 20
<210> 1153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1153
ctgttcacaa aaatgtgtta 20
<210> 1154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1154
tcatttaatc attaattttg 20
<210> 1155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1155
gattttgctt attaagctca 20
<210> 1156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1156
gtgagccaat gatcccatca 20
<210> 1157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1157
tcagcccctt aaaaatcatc 20
<210> 1158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1158
ggatatgttc agactcagat 20
<210> 1159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1159
ccagttcata ctcagaaata 20
<210> 1160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1160
tggcactgaa tattaagcag 20
<210> 1161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1161
agtgtgtatt accaacaact 20
<210> 1162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1162
ctgtataata atgtaatgct 20
<210> 1163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1163
tctatttaaa acactgaatc 20
<210> 1164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1164
gggagcaatg aattctctca 20
<210> 1165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1165
ctactatatc taaacactat 20
<210> 1166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1166
ttcctccatc catcccccta 20
<210> 1167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1167
agcccatttt ttcatccagt 20
<210> 1168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1168
tgtggcttta ccgcctaaca 20
<210> 1169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1169
tctcctcttt ataccaggga 20
<210> 1170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1170
tattttttta ctacctccac 20
<210> 1171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1171
agtgaccaca ctatccgatg 20
<210> 1172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1172
cttgaattta aaacccatat 20
<210> 1173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1173
tgcacacatc tcaaataggt 20
<210> 1174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1174
tttgcctaaa ttctgccttt 20
<210> 1175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1175
ctcaccaacc tcatctctcg 20
<210> 1176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1176
acaactaact atatattgtt 20
<210> 1177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1177
gtttccctct aaagacttca 20
<210> 1178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1178
gaccagaagc cttagttcca 20
<210> 1179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1179
acacagaaac atatatgtgc 20
<210> 1180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1180
attggccccc aaacccattt 20
<210> 1181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1181
tctgaatgaa tattggctat 20
<210> 1182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1182
gatgagaatt aaactgctat 20
<210> 1183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1183
gagtcataca tatagacttt 20
<210> 1184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1184
tcaggataca ccaagggagg 20
<210> 1185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1185
aactgctatt atcatacagg 20
<210> 1186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1186
cccggccacc agggttgccc 20
<210> 1187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1187
gatactctac caaaacttca 20
<210> 1188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1188
cccacgctgc ctctacttgc 20
<210> 1189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1189
gcactagtaa aaagcagaaa 20
<210> 1190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1190
gtttaaagtg agatacagta 20
<210> 1191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1191
aggttcttta aaagttcatc 20
<210> 1192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1192
ggtttgtacc aaacattaaa 20
<210> 1193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1193
tacaccccag aaaacggttt 20
<210> 1194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1194
ctattgctcc aaaccatgtg 20
<210> 1195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1195
actggccaac acgctcagaa 20
<210> 1196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1196
accaacatag aaaattatcc 20
<210> 1197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1197
agtaaagatc aaactgtgca 20
<210> 1198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1198
tgggttaaaa acaaatgtgg 20
<210> 1199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1199
tcagcttctc aaatcaggtg 20
<210> 1200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1200
tagtaattct tccaggccat 20
<210> 1201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1201
ttctggcctc tttatattaa 20
<210> 1202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1202
cttgagtcct ttcagataag 20
<210> 1203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1203
tctgatatta aaacatccag 20
<210> 1204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1204
gcatatggaa aaaagttctc 20
<210> 1205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1205
tactgaaaca ataaacttgt 20
<210> 1206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1206
tcttcctcct tttatatctg 20
<210> 1207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1207
ggattaaaaa ttatgacctc 20
<210> 1208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1208
ggagcagttc cttaactatc 20
<210> 1209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1209
ccccttaccc aaacccttgg 20
<210> 1210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1210
agagataatt tttaatgcag 20
<210> 1211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1211
ccattaaaca tttattttgc 20
<210> 1212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1212
tctatattcc cttaaccgta 20
<210> 1213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1213
cattttcaac cttatgatat 20
<210> 1214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1214
cagacattcc tttaatatgc 20
<210> 1215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1215
tagaactttt aaagcaaggc 20
<210> 1216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1216
agtcaaatag tctatcagta 20
<210> 1217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1217
acatgatttt aaaagtctta 20
<210> 1218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1218
tccccacacc cttaaactgc 20
<210> 1219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1219
tacacataaa tttatatctg 20
<210> 1220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1220
tggttctata tttatgtacc 20
<210> 1221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1221
ttgtctaaac ctgtttgagg 20
<210> 1222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1222
gctaccaaaa tacagaactt 20
<210> 1223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1223
gcaccatttt aaaaatggct 20
<210> 1224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1224
tcatctaaac ctaatacggc 20
<210> 1225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1225
tctgtctttt cctggtaaga 20
<210> 1226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1226
ctgttgtttg ccacatttcc 20
<210> 1227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1227
ccagagctaa ttcctaggag 20
<210> 1228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1228
ttgggcagtg aaagaaatgg 20
<210> 1229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1229
acctacagtg acatctcata 20
<210> 1230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1230
tctgttcaca aaaatgtgtt 20
<210> 1231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1231
ctctttcatt taatcattaa 20
<210> 1232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1232
tccccaatca aatttgtgat 20
<210> 1233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1233
gtagtggtac acacccatag 20
<210> 1234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1234
ggcatctttc cacagtctta 20
<210> 1235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1235
ccgagccatc taagttgaag 20
<210> 1236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1236
atccagttca tactcagaaa 20
<210> 1237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1237
cacccacgcc aggacagtcg 20
<210> 1238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1238
ttccagcacc agaacagaca 20
<210> 1239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1239
tctgtataat aatgtaatgc 20
<210> 1240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1240
gttctattta aaacactgaa 20
<210> 1241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1241
catacaaatt tcgcctgttg 20
<210> 1242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1242
actactatat ctaaacacta 20
<210> 1243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1243
taccccttcc tccatccatc 20
<210> 1244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1244
ctcaatatag cccatttttt 20
<210> 1245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1245
gacctccccc agggagagga 20
<210> 1246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1246
ttctcctctt tataccaggg 20
<210> 1247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1247
actatttttt tactacctcc 20
<210> 1248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1248
accagtgacc acactatccg 20
<210> 1249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1249
ccttgaattt aaaacccata 20
<210> 1250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1250
gaaagttaaa atcttgttgc 20
<210> 1251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1251
ctttttgcct aaattctgcc 20
<210> 1252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1252
tctcaccaac ctcatctctc 20
<210> 1253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1253
aacaactaac tatatattgt 20
<210> 1254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1254
agtgcaaaag tcaggataca 20
<210> 1255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1255
tcagaagacc agaagcctta 20
<210> 1256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1256
acatttacat cacacacaga 20
<210> 1257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1257
ggattttatc ccagtcattg 20
<210> 1258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1258
gaggaatgaa aatggtagat 20
<210> 1259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1259
cagatgagaa ttaaactgct 20
<210> 1260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1260
agagtcatac atatagactt 20
<210> 1261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1261
atggagttca ggatacacca 20
<210> 1262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1262
ggtcttagat tttatgagct 20
<210> 1263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1263
ggccccggcc accagggttg 20
<210> 1264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1264
ggatactcta ccaaaacttc 20
<210> 1265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1265
gtttcctttc ccccacgctg 20
<210> 1266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1266
tgcactagta aaaagcagaa 20
<210> 1267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1267
ttttttcccc aaagagttta 20
<210> 1268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1268
aaggttcttt aaaagttcat 20
<210> 1269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1269
tgggtttgta ccaaacatta 20
<210> 1270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1270
ctaaacctat tcaaatgttt 20
<210> 1271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1271
atgatgttcc tattgctcca 20
<210> 1272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1272
tcttcctatt tgaagagaaa 20
<210> 1273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1273
gggaaaacga aaagttgacc 20
<210> 1274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1274
tcagtaaaga tcaaactgtg 20
<210> 1275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1275
tctgggttaa aaacaaatgt 20
<210> 1276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1276
cttcagcttc tcaaatcagg 20
<210> 1277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1277
ataggtatag tttaagagcc 20
<210> 1278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1278
atgctccgta tttattctgg 20
<210> 1279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1279
gacttgagtc ctttcagata 20
<210> 1280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1280
atctgatatt aaaacatcca 20
<210> 1281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1281
tacaatattt tacactggaa 20
<210> 1282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1282
gcactgttat tttattagta 20
<210> 1283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1283
ctgtggtttt aaaggctgta 20
<210> 1284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1284
ggttttaaaa acatcctcct 20
<210> 1285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1285
ttttagcacc tttaaactct 20
<210> 1286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1286
ctctcatttt aaagttttct 20
<210> 1287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1287
atctttattc aaaaatgcaa 20
<210> 1288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1288
ttcatgtttt aaagctgaga 20
<210> 1289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1289
ctcacaattc aaaattattc 20
<210> 1290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1290
aaccttagaa atgtacattt 20
<210> 1291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1291
ctagcaattc aaaacaatat 20
<210> 1292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1292
cttctccttc cttaatagat 20
<210> 1293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1293
tctcaaggcc cttaattgcc 20
<210> 1294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1294
acttttaaat ccccctaaag 20
<210> 1295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1295
ctcacatttc tttatacaca 20
<210> 1296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1296
gtgagatttt aaagacattc 20
<210> 1297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1297
gatgccaaac tattatctca 20
<210> 1298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1298
agacaatttt aaaagcttcc 20
<210> 1299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1299
tctcttaacc aaagaatctg 20
<210> 1300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1300
atgctgttcc tttataacgg 20
<210> 1301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1301
aatttctaaa tttagcccag 20
<210> 1302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1302
tcccctcact ccaacggcat 20
<210> 1303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1303
ctcccatgaa accacaataa 20
<210> 1304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1304
ctgactttta tatgcaaacc 20
<210> 1305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1305
ctcgatagcc aggaaagctc 20
<210> 1306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1306
actgtaaacc tacagtgaca 20
<210> 1307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1307
ctctgttcac aaaaatgtgt 20
<210> 1308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1308
ttctctttca tttaatcatt 20
<210> 1309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1309
ttccccaatc aaatttgtga 20
<210> 1310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1310
gagattatct cctatgaaga 20
<210> 1311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1311
agcatttttc tcctacattg 20
<210> 1312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1312
ggcccgagcc atctaagttg 20
<210> 1313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1313
aatccagttc atactcagaa 20
<210> 1314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1314
actcacaccc acgccaggac 20
<210> 1315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1315
ccacaaacaa aaatgtggtt 20
<210> 1316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1316
ctgttctgta taataatgta 20
<210> 1317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1317
tgttctattt aaaacactga 20
<210> 1318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1318
gacatacaaa tttcgcctgt 20
<210> 1319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1319
aactactata tctaaacact 20
<210> 1320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1320
ctgcctaccc cttcctccat 20
<210> 1321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1321
gacagctcaa tatagcccat 20
<210> 1322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1322
agccagaact aaagtgggct 20
<210> 1323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1323
ccttctcctc tttataccag 20
<210> 1324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1324
atactatttt tttactacct 20
<210> 1325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1325
gacaccagtg accacactat 20
<210> 1326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1326
tccttgaatt taaaacccat 20
<210> 1327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1327
tgaaagttaa aatcttgttg 20
<210> 1328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1328
tctttttgcc taaattctgc 20
<210> 1329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1329
tcctctcacc aacctcatct 20
<210> 1330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1330
cttttagaaa ctaactctgg 20
<210> 1331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1331
gtactataat tgattagtgc 20
<210> 1332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1332
gtgacattca gaagaccaga 20
<210> 1333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1333
actacattta catcacacac 20
<210> 1334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1334
ttaggatttt atcccagtca 20
<210> 1335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1335
gcattataga aaatactaaa 20
<210> 1336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1336
gcagatgaga attaaactgc 20
<210> 1337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1337
tcatatagag tcatacatat 20
<210> 1338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1338
tgaacattcc aaagtggagc 20
<210> 1339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1339
gcggtcttag attttatgag 20
<210> 1340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1340
ccctgccggc ccatgcctcc 20
<210> 1341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1341
cacaaaaaaa ggatactcta 20
<210> 1342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1342
atctggatac aaatgataag 20
<210> 1343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1343
gtccaccaca acaccctggt 20
<210> 1344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1344
cagagctgaa atgtagttac 20
<210> 1345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1345
gcaaggttct ttaaaagttc 20
<210> 1346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1346
atgaaatacc ctttctgggt 20
<210> 1347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1347
tagctattct aaacctattc 20
<210> 1348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1348
tgatgatgtt cctattgctc 20
<210> 1349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1349
gaagaatttc tacccctgtc 20
<210> 1350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1350
atcccaaact aaactgggtg 20
<210> 1351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1351
aacatatttc agtaaagatc 20
<210> 1352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1352
tctatttcag aaattctggg 20
<210> 1353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1353
tgcttcaaaa ttttgttttc 20
<210> 1354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1354
ttcccctccc tcagacgagg 20
<210> 1355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1355
attctgagaa gatgctccgt 20
<210> 1356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1356
aagacttgag tcctttcaga 20
<210> 1357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1357
gatctgatat taaaacatcc 20
<210> 1358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1358
agtacaatat tttacactgg 20
<210> 1359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1359
gtcaagtttt aaaatgtgac 20
<210> 1360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1360
actgaaacaa tttatctaag 20
<210> 1361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1361
acaaaaataa tttaagccac 20
<210> 1362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1362
tactatcacc tttaaacttt 20
<210> 1363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1363
accgccaaaa ccaaccaggg 20
<210> 1364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1364
ctaatctatc aaataaagga 20
<210> 1365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1365
gagaggtttc attatgtaaa 20
<210> 1366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1366
gcacttagac aatgctgcag 20
<210> 1367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1367
ggtaagttat tttaaaactt 20
<210> 1368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1368
agttttacga tatatgaatc 20
<210> 1369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1369
taccattatt tttagctttt 20
<210> 1370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1370
cagtttattc tttacccaaa 20
<210> 1371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1371
cccacatttt aaagatgcag 20
<210> 1372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1372
tccagaaacc tttattattg 20
<210> 1373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1373
aacaggttac aaatacggtt 20
<210> 1374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1374
attctgtttt aaattccttt 20
<210> 1375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1375
atgcaatttc aaaagctggc 20
<210> 1376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1376
gtggatactt tttaaaactc 20
<210> 1377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1377
gtcgcaaacc tttatggagt 20
<210> 1378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1378
caaatccaaa tttattcttc 20
<210> 1379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1379
catctaatcc cctcactcca 20
<210> 1380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1380
gcctcccatg aaaccacaat 20
<210> 1381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1381
cctgactttt atatgcaaac 20
<210> 1382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1382
aagtacgctc gatagccagg 20
<210> 1383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1383
aagactgtaa acctacagtg 20
<210> 1384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1384
cctctgttca caaaaatgtg 20
<210> 1385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1385
atttctcttt catttaatca 20
<210> 1386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1386
cttccccaat caaatttgtg 20
<210> 1387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1387
agagattatc tcctatgaag 20
<210> 1388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1388
agggatagtg acaaacacgg 20
<210> 1389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1389
agggcccgag ccatctaagt 20
<210> 1390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1390
cccctcaaat ccagttcata 20
<210> 1391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1391
catcatgata acaactgctg 20
<210> 1392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1392
cccacaaaca aaaatgtggt 20
<210> 1393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1393
gagtaaaatg atcagtgggt 20
<210> 1394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1394
gtgttctatt taaaacactg 20
<210> 1395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1395
agacatacaa atttcgcctg 20
<210> 1396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1396
gtcaataact actatatcta 20
<210> 1397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1397
tctgcctacc ccttcctcca 20
<210> 1398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1398
ccacagataa ccaaagcacg 20
<210> 1399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1399
ccagccagaa ctaaagtggg 20
<210> 1400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1400
ggccccttct cctctttata 20
<210> 1401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1401
tgatactatt tttttactac 20
<210> 1402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1402
gagacagaac atacacgcaa 20
<210> 1403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1403
attccttgaa tttaaaaccc 20
<210> 1404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1404
gtgaaagtta aaatcttgtt 20
<210> 1405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1405
tgtttctttt tgcctaaatt 20
<210> 1406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1406
ttttcctctc accaacctca 20
<210> 1407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1407
acttttagaa actaactctg 20
<210> 1408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1408
gccctttata acaggtacta 20
<210> 1409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1409
tgtgacattc agaagaccag 20
<210> 1410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1410
tcaaaactac atttacatca 20
<210> 1411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1411
ggtttaggat tttatcccag 20
<210> 1412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1412
tgcattatag aaaatactaa 20
<210> 1413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1413
ggcagatgag aattaaactg 20
<210> 1414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1414
cagggcttct catatagagt 20
<210> 1415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1415
ggcacttgaa cattccaaag 20
<210> 1416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1416
gctcacaagc ccagcgcggt 20
<210> 1417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1417
tgttgtaaac caagctccac 20
<210> 1418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1418
gtccaaacac aaaaaaagga 20
<210> 1419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1419
tattttagcc tacagtacag 20
<210> 1420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1420
cctgtccacc acaacaccct 20
<210> 1421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1421
tcagcaattc tgcagagctg 20
<210> 1422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1422
aagttataaa ctcaatatgt 20
<210> 1423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1423
tatgaaatac cctttctggg 20
<210> 1424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1424
tctagctatt ctaaacctat 20
<210> 1425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1425
ccacaaaaat tatgatgatg 20
<210> 1426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1426
cgaagaattt ctacccctgt 20
<210> 1427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1427
tcatcccaaa ctaaactggg 20
<210> 1428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1428
gcaacatatt tcagtaaaga 20
<210> 1429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1429
cttaaattct ctatttcaga 20
<210> 1430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1430
gtgcttcaaa attttgtttt 20
<210> 1431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1431
accgagttcc cctccctcag 20
<210> 1432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1432
acaggaatac tattctgaga 20
<210> 1433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1433
gaagcctcca atgtatctgc 20
<210> 1434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1434
ggtgtctgtt ttcccttggc 20
<210> 1435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1435
aagtacaata ttttacactg 20
<210> 1436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1436
ggccataaaa ttgtaaactg 20
<210> 1437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1437
aacatctaaa tttataatga 20
<210> 1438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1438
aggtggttac aaacataaat 20
<210> 1439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1439
agctaaaaac ccaacatggg 20
<210> 1440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1440
gacagttatt tttaagaggc 20
<210> 1441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1441
ttggactttt aaatgtaagt 20
<210> 1442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1442
tgtgtctaaa tttatggtag 20
<210> 1443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1443
gttgaatttc aaaaatcaaa 20
<210> 1444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1444
caggaaaaaa tacagggtgt 20
<210> 1445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1445
acctaaaaaa atatagatcc 20
<210> 1446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1446
ctaattaatc cttaaattgc 20
<210> 1447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1447
tttcaatata tttacacact 20
<210> 1448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1448
ctcacacaaa tttacattct 20
<210> 1449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1449
acctaaaaaa tacatcttta 20
<210> 1450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1450
ctgaagattc cttaatatct 20
<210> 1451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1451
ctaatgtttt aaaactcttg 20
<210> 1452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1452
ttccaatttt aaaaaacctg 20
<210> 1453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1453
ctgtcaaaaa tataatacct 20
<210> 1454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1454
tgtcgcaaac ctttatggag 20
<210> 1455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1455
aagtcctttc aaagccaagt 20
<210> 1456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1456
agcatctaat cccctcactc 20
<210> 1457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1457
aacccgttta ccctgcctcc 20
<210> 1458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1458
gcctgacttt tatatgcaaa 20
<210> 1459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1459
acacttgtag aaagtacgct 20
<210> 1460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1460
cttccaaaga ctgtaaacct 20
<210> 1461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1461
gcctctgttc acaaaaatgt 20
<210> 1462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1462
aagccaattt ctctttcatt 20
<210> 1463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1463
cacaacttcc ccaatcaaat 20
<210> 1464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1464
ctcaagagat tatctcctat 20
<210> 1465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1465
acagggatag tgacaaacac 20
<210> 1466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1466
ctgtgaatca ctttctcagg 20
<210> 1467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1467
acccctcaaa tccagttcat 20
<210> 1468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1468
gtagacagcc agtaagtaca 20
<210> 1469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1469
acccacaaac aaaaatgtgg 20
<210> 1470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1470
cgccaatgtg aaaaggcgac 20
<210> 1471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1471
agtgttctat ttaaaacact 20
<210> 1472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1472
ccagacatac aaatttcgcc 20
<210> 1473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1473
agtcaataac tactatatct 20
<210> 1474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1474
ccagcaagcc catgtgctca 20
<210> 1475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1475
agtaccacag ataaccaaag 20
<210> 1476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1476
ctgtatggaa aaacattgca 20
<210> 1477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1477
atgatgatca ttatgtagag 20
<210> 1478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1478
aatgatacta tttttttact 20
<210> 1479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1479
ggagacagaa catacacgca 20
<210> 1480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1480
tctgtgaatt ccttgaattt 20
<210> 1481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1481
ggtgaaagtt aaaatcttgt 20
<210> 1482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1482
tctttaatca cttcaaaggc 20
<210> 1483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1483
ggctttccca ataaacctgc 20
<210> 1484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1484
gtacttttag aaactaactc 20
<210> 1485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1485
aagcccttta taacaggtac 20
<210> 1486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1486
gcccaacacc aggcagaggt 20
<210> 1487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1487
tttcaaaact acatttacat 20
<210> 1488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1488
ttgtaaattt tacgaatagt 20
<210> 1489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1489
accatcaaca gatctgcatt 20
<210> 1490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1490
gcctagcccc aaacaggaaa 20
<210> 1491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1491
aggatgcacc agggcttctc 20
<210> 1492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1492
gggcctgttt tctcctgaag 20
<210> 1493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1493
ggctcacaag cccagcgcgg 20
<210> 1494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1494
ctgttgtaaa ccaagctcca 20
<210> 1495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1495
atgaccagcc ctgtccaaac 20
<210> 1496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1496
actgtgttat tttagcctac 20
<210> 1497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1497
cccaaccccc cttaccccat 20
<210> 1498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1498
cattgaaact ttcaatatct 20
<210> 1499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1499
caggaatatc acacaagtta 20
<210> 1500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1500
ctatgaaata ccctttctgg 20
<210> 1501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1501
ttctagctat tctaaaccta 20
<210> 1502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1502
aaccacaaaa attatgatga 20
<210> 1503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1503
ccgaagaatt tctacccctg 20
<210> 1504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1504
atcatcccaa actaaactgg 20
<210> 1505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1505
ttttggcaac atatttcagt 20
<210> 1506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1506
tgttcttaaa ttctctattt 20
<210> 1507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1507
gagtgcttca aaattttgtt 20
<210> 1508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1508
cagtattctc aaatcgcaga 20
<210> 1509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1509
ggacaggaat actattctga 20
<210> 1510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1510
gggtgaagcc tccaatgtat 20
<210> 1511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1511
ccctcaaccc aagttctggt 20
<210> 1512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1512
gcaagtacaa tattttacac 20
<210> 1513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1513
cactgaaaaa tatatgttca 20
<210> 1514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1514
cactataaaa acatctaaca 20
<210> 1515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1515
ttcaacaata tttatgccca 20
<210> 1516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1516
cagctaaaaa cccaacatgg 20
<210> 1517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1517
agttatatat tttagctgaa 20
<210> 1518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1518
gctatatttt aaaaaggatc 20
<210> 1519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1519
ctttcatttc aaacttactg 20
<210> 1520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1520
actttctttt aaattctaac 20
<210> 1521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1521
gatggtaatt tttagaggtg 20
<210> 1522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1522
tctttctata tttatctata 20
<210> 1523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1523
gtttacaaaa tatttgcaca 20
<210> 1524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1524
tctatcaaac ctaatctatc 20
<210> 1525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1525
aaggaatttc tttacaccat 20
<210> 1526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1526
gcacttcgaa tttataccac 20
<210> 1527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1527
aacataaaaa atatacctaa 20
<210> 1528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1528
gctgttaaaa tatgctttcc 20
<210> 1529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1529
gggcactacc cttatcttaa 20
<210> 1530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1530
cctgtcaaaa atataatacc 20
<210> 1531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1531
cctttaaaaa tatgcctttt 20
<210> 1532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1532
ccaataaaac cccacagggt 20
<210> 1533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1533
ctttagcatc taatcccctc 20
<210> 1534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1534
aaacccgttt accctgcctc 20
<210> 1535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1535
ggcctgactt ttatatgcaa 20
<210> 1536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1536
gttttcaaat cctagatgga 20
<210> 1537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1537
gggcccttcc aaagactgta 20
<210> 1538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1538
acctcttttc acacctgcct 20
<210> 1539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1539
cacagggaag ccaatttctc 20
<210> 1540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1540
catctcttct tccacaactt 20
<210> 1541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1541
ctctcaagag attatctcct 20
<210> 1542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1542
ctttcctccc acagcaccta 20
<210> 1543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1543
gatttatttt tcagctgtga 20
<210> 1544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1544
tgcacccctc aaatccagtt 20
<210> 1545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1545
ccatcggtag acagccagta 20
<210> 1546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1546
ggtacaaaga cccacaaaca 20
<210> 1547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1547
aacataatat tcagtgctaa 20
<210> 1548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1548
gagtgttcta tttaaaacac 20
<210> 1549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1549
tcccagacat acaaatttcg 20
<210> 1550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1550
tagtcaataa ctactatatc 20
<210> 1551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1551
gccagcaagc ccatgtgctc 20
<210> 1552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1552
cagtaccaca gataaccaaa 20
<210> 1553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1553
gctcagttaa aatctgaaag 20
<210> 1554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1554
gtgggctcaa gatatcttcc 20
<210> 1555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1555
agaatgatac tattttttta 20
<210> 1556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1556
gcctcccacc aggagacaga 20
<210> 1557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1557
gatgtcatct tcaactggaa 20
<210> 1558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1558
ttctttggtg aaagttaaaa 20
<210> 1559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1559
ttcttcttta atcacttcaa 20
<210> 1560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1560
tctggctttc ccaataaacc 20
<210> 1561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1561
aacaacaatc atgtactttt 20
<210> 1562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1562
acaagccctt tataacaggt 20
<210> 1563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1563
ttgcccaaca ccaggcagag 20
<210> 1564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1564
gtttcaaaac tacatttaca 20
<210> 1565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1565
tcttccaatt ttgtaaattt 20
<210> 1566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1566
caccatcaac agatctgcat 20
<210> 1567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1567
aggcctagcc ccaaacagga 20
<210> 1568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1568
cagatcttaa aaaaggatgc 20
<210> 1569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1569
atcaggaaaa gatgatggcc 20
<210> 1570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1570
agagcaccca cttagctttc 20
<210> 1571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1571
aacctattcc ctgttgtaaa 20
<210> 1572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1572
acggcaaatc aaagagctgg 20
<210> 1573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1573
acagaaacct aaaattaaga 20
<210> 1574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1574
acccccaacc ccccttaccc 20
<210> 1575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1575
cctttaaacc acattgaaac 20
<210> 1576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1576
gcaggaatat cacacaagtt 20
<210> 1577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1577
aactatgaaa taccctttct 20
<210> 1578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1578
aaggaactat tctagctatt 20
<210> 1579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1579
tagaaccaca aaaattatga 20
<210> 1580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1580
accgaagaat ttctacccct 20
<210> 1581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1581
aacagaaatc aaatcatccc 20
<210> 1582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1582
aacaaaaata aattttggca 20
<210> 1583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1583
atgtgttctt aaattctcta 20
<210> 1584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1584
tgtactcctc aaagtgagtg 20
<210> 1585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1585
acagtattct caaatcgcag 20
<210> 1586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1586
ctgtccagtt tccactgtcc 20
<210> 1587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1587
cagcaaacaa actaaaggga 20
<210> 1588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1588
gccctcaacc caagttctgg 20
<210> 1589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1589
tatgaattct tccatttttt 20
<210> 1590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1590
aacattattc aaagaaatgt 20
<210> 1591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1591
aggcagaaca tttaacatcg 20
<210> 1592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1592
tctgtgttta tttaggtttc 20
<210> 1593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1593
actgcatttc aaaacctaca 20
<210> 1594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1594
ttgaagtttt aaagtacatg 20
<210> 1595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1595
atgtttaaaa tatgcatgcc 20
<210> 1596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1596
tttctcagaa tataactgta 20
<210> 1597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1597
gtgtaatttc aaaatagggt 20
<210> 1598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1598
agctttcaaa tttatccact 20
<210> 1599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1599
acttagccaa tttaactgca 20
<210> 1600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1600
tctttaaaac tattagtcac 20
<210> 1601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1601
ctaatctatc aaacctaatc 20
<210> 1602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1602
tcagttaaaa tacctgatga 20
<210> 1603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1603
ggttaatatt tttatggtat 20
<210> 1604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1604
gttataattt aaaaagtgtt 20
<210> 1605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1605
ccgttttatt tttaaactcg 20
<210> 1606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1606
gcttcatttt aaaagattgt 20
<210> 1607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1607
ccacataaaa tatcgaatca 20
<210> 1608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1608
cagggctgta tttaattctg 20
<210> 1609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1609
gttctcaatc cttaatgatt 20
<210> 1610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1610
gacatatttt aaaacatgga 20
<210> 1611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1611
aaccaatcct aaacccgttt 20
<210> 1612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1612
aggcctgact tttatatgca 20
<210> 1613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1613
tgttttcaaa tcctagatgg 20
<210> 1614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1614
ttttaaataa gatctttggg 20
<210> 1615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1615
aacctctttt cacacctgcc 20
<210> 1616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1616
agtagagaga tttagtgatc 20
<210> 1617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1617
ggagaaaacc atctcttctt 20
<210> 1618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1618
gcattaaaaa acggaaccct 20
<210> 1619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1619
ttcccctttc ctcccacagc 20
<210> 1620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1620
tgatttattt ttcagctgtg 20
<210> 1621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1621
aatgcacccc tcaaatccag 20
<210> 1622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1622
agtcaaccaa aaaatagtag 20
<210> 1623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1623
agagaggtac aaagacccac 20
<210> 1624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1624
aacaacataa tattcagtgc 20
<210> 1625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1625
tgagtgtaag aatctctgtg 20
<210> 1626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1626
acactatccc agacatacaa 20
<210> 1627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1627
ccacttagtc aataactact 20
<210> 1628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1628
tgccagcaag cccatgtgct 20
<210> 1629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1629
gagcagtacc acagataacc 20
<210> 1630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1630
tgctcagtta aaatctgaaa 20
<210> 1631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1631
ctctagtttc catagcttcc 20
<210> 1632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1632
ttccaaatac acctagaatg 20
<210> 1633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1633
cttgcctccc accaggagac 20
<210> 1634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1634
tgatgtcatc ttcaactgga 20
<210> 1635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1635
ggtttttttc ccttctttgg 20
<210> 1636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1636
gattcttctt taatcacttc 20
<210> 1637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1637
ctcatcatct tctcaatttc 20
<210> 1638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1638
cacaaacaac aatcatgtac 20
<210> 1639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1639
ctacaagccc tttataacag 20
<210> 1640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1640
tattcttgcc caacaccagg 20
<210> 1641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1641
ggtttcaaaa ctacatttac 20
<210> 1642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1642
tctcaggtac aaactttaca 20
<210> 1643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1643
ttcaccatca acagatctgc 20
<210> 1644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1644
agacagtttc aagaaggcct 20
<210> 1645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1645
tcagatctta aaaaaggatg 20
<210> 1646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1646
aagatagtaa aaaggccagg 20
<210> 1647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1647
atcgaacccc agtaatgaca 20
<210> 1648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1648
ttgtgtaaac ctattccctg 20
<210> 1649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1649
acacggcaaa tcaaagagct 20
<210> 1650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1650
aaggttagaa cagaaaccta 20
<210> 1651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1651
cacccccaac cccccttacc 20
<210> 1652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1652
ccctttaaac cacattgaaa 20
<210> 1653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1653
ccccaaacct ttcccacaat 20
<210> 1654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1654
atgatatttc ggatctctgg 20
<210> 1655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1655
gtcaaggaac tattctagct 20
<210> 1656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1656
attcctatac ctgaaataga 20
<210> 1657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1657
caccgaagaa tttctacccc 20
<210> 1658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1658
ctcacaattc caagttagaa 20
<210> 1659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1659
agtagtcaca gatgttaaag 20
<210> 1660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1660
gatgtgttct taaattctct 20
<210> 1661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1661
acctgtactc ctcaaagtga 20
<210> 1662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1662
aacagtattc tcaaatcgca 20
<210> 1663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1663
cttaatatcc ccacagctgt 20
<210> 1664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1664
ttggccatcc agacagcaaa 20
<210> 1665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1665
tgccctcaac ccaagttctg 20
<210> 1666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1666
atatgaattc ttccattttt 20
<210> 1667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1667
cgttataaaa tatattacta 20
<210> 1668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1668
gcaagatgaa tttatcctcc 20
<210> 1669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1669
cacaacttat tttaatgtca 20
<210> 1670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1670
tgagtatttt aaactcttct 20
<210> 1671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1671
attccattat tttagaaagc 20
<210> 1672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1672
acttgcaaaa tttcaagttt 20
<210> 1673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1673
agcaagttaa tttatggcca 20
<210> 1674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1674
gattgaatca tttacctcgc 20
<210> 1675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1675
atctgctttc tttattccct 20
<210> 1676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1676
atctctgtta tttaacactg 20
<210> 1677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1677
ttctttaaaa ctattagtca 20
<210> 1678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1678
gacctcaaaa ccaaattagg 20
<210> 1679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1679
tctgaaattc aaaatcagtg 20
<210> 1680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1680
ccactggaaa tttaacatga 20
<210> 1681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1681
tgtatcaccc attaactgac 20
<210> 1682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1682
gactaaaaaa tatacatctc 20
<210> 1683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1683
ggtctatttc tttacagcac 20
<210> 1684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1684
ttcttctgta tttaattctt 20
<210> 1685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1685
actgagtttc aaagcaaaga 20
<210> 1686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1686
atccgatttt aaaacaaaca 20
<210> 1687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1687
agacatattt taaaacatgg 20
<210> 1688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1688
taaccaatcc taaacccgtt 20
<210> 1689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1689
attagctaat tcctagaggc 20
<210> 1690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1690
tgaatgtttt caaatcctag 20
<210> 1691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1691
ccatttattt taaaaatcct 20
<210> 1692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1692
catttctaaa caaaacctct 20
<210> 1693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1693
cagtagagag atttagtgat 20
<210> 1694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1694
tggagaaaac catctcttct 20
<210> 1695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1695
gtgaagcatt aaaaaacgga 20
<210> 1696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1696
ctggcattcc cctttcctcc 20
<210> 1697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1697
ttgatttatt tttcagctgt 20
<210> 1698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1698
ccaatgcacc cctcaaatcc 20
<210> 1699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1699
ccgatgactc acagctcaca 20
<210> 1700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1700
gagagcattt ttctcctttt 20
<210> 1701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1701
gaacaacata atattcagtg 20
<210> 1702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1702
tcattaataa aaacagtcaa 20
<210> 1703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1703
tgacactatc ccagacatac 20
<210> 1704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1704
caccacttag tcaataacta 20
<210> 1705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1705
ccaccctcct ccactctttc 20
<210> 1706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1706
gggagcagta ccacagataa 20
<210> 1707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1707
gtgctcagtt aaaatctgaa 20
<210> 1708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1708
ccctctagtt tccatagctt 20
<210> 1709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1709
cttttccaaa tacacctaga 20
<210> 1710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1710
ttggttaaga cctagtttct 20
<210> 1711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1711
tggatgtgaa acagagacgg 20
<210> 1712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1712
ataaggtttt tttcccttct 20
<210> 1713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1713
agattcttct ttaatcactt 20
<210> 1714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1714
gagatggtac tttagaaggc 20
<210> 1715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1715
acacaaacaa caatcatgta 20
<210> 1716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1716
tgtctacaag ccctttataa 20
<210> 1717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1717
tgcttattct tgcccaacac 20
<210> 1718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1718
tggtttcaaa actacattta 20
<210> 1719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1719
ggctattttt ataatgtgaa 20
<210> 1720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1720
acagtaatta aaagaattca 20
<210> 1721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1721
cagaagttaa tacttgagga 20
<210> 1722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1722
gcaaaatatc agatcttaaa 20
<210> 1723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1723
ggacagcaaa taagatagta 20
<210> 1724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1724
ccagtcaatc gaaccccagt 20
<210> 1725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1725
tttgtgtaaa cctattccct 20
<210> 1726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1726
gcagacatcc ccaactgaga 20
<210> 1727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1727
ctcctgcgac acacctgctg 20
<210> 1728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1728
attggttttc ctaacactgc 20
<210> 1729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1729
tccctttaaa ccacattgaa 20
<210> 1730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1730
cccccaaacc tttcccacaa 20
<210> 1731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1731
cccacaaatg atatttcgga 20
<210> 1732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1732
ggtaatgaaa ttcgaggaaa 20
<210> 1733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1733
ttttataatt cctatacctg 20
<210> 1734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1734
ggcaccgaag aatttctacc 20
<210> 1735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1735
gctcacaatt ccaagttaga 20
<210> 1736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1736
cttagtagtc acagatgtta 20
<210> 1737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1737
tatatttatt acttgatgtg 20
<210> 1738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1738
attttttaaa acattacctg 20
<210> 1739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1739
agaagtactt tcagcatagg 20
<210> 1740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1740
gcttaatatc cccacagctg 20
<210> 1741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1741
ttggccacag aaaaggagac 20
<210> 1742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1742
tggtagtgcc ctcaacccaa 20
<210> 1743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1743
ccacgattag aaaatagaat 20
<210> 1744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1744
tcaaacaaaa tataatgctt 20
<210> 1745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1745
ctacacaaaa ccaatcactt 20
<210> 1746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1746
cgccttaatt tttattatag 20
<210> 1747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1747
ccatttagaa tatagctgtt 20
<210> 1748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1748
attctcatcc attatacttt 20
<210> 1749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1749
ttaccaaaaa ccatttgtgt 20
<210> 1750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1750
tccttctttc aaagttcacc 20
<210> 1751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1751
ctgccactat tttatgtctg 20
<210> 1752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1752
cccaggttcc cttatcatct 20
<210> 1753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1753
ttctgcaaat aattccgtca 20
<210> 1754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1754
ccatcatttc tttaaaacta 20
<210> 1755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1755
aagtacatac aaatacatat 20
<210> 1756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1756
cctatcaaag ccacaacttc 20
<210> 1757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1757
ttgtatacca tttatgtttc 20
<210> 1758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1758
ccactcaaac ctttcaatgc 20
<210> 1759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1759
gagctcaaac ccaagtctgt 20
<210> 1760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1760
accctatttc cttaatgtaa 20
<210> 1761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1761
ctccttcacc cttaaggcta 20
<210> 1762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1762
atcgagtcct tttaaacaaa 20
<210> 1763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1763
acaactcgcc attaacacta 20
<210> 1764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1764
agctaataag acatatttta 20
<210> 1765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1765
ctaaccaatc ctaaacccgt 20
<210> 1766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1766
gattagctaa ttcctagagg 20
<210> 1767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1767
ttgaatgttt tcaaatccta 20
<210> 1768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1768
gccatttatt ttaaaaatcc 20
<210> 1769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1769
gcatttctaa acaaaacctc 20
<210> 1770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1770
tgaggaagcc cttcccggca 20
<210> 1771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1771
ttggagaaaa ccatctcttc 20
<210> 1772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1772
ggaaagtata aaagtgaagc 20
<210> 1773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1773
gcacgcagta acaatggaca 20
<210> 1774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1774
ctttgattta tttttcagct 20
<210> 1775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1775
cccttgtttc tgcattggtt 20
<210> 1776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1776
tgttaccacc gatgactcac 20
<210> 1777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1777
gcacatacag tttaaaggag 20
<210> 1778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1778
ggtccctgtt cctagggagg 20
<210> 1779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1779
gcaatgttta aaaatcatta 20
<210> 1780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1780
ttcatgacac tatcccagac 20
<210> 1781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1781
cctttcacca cttagtcaat 20
<210> 1782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1782
gcctcccacc ctcctccact 20
<210> 1783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1783
atgaaaataa actcatggga 20
<210> 1784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1784
gtctaaaaga cttcctagca 20
<210> 1785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1785
tctatttaaa ataacaaccc 20
<210> 1786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1786
ttccttttcc aaatacacct 20
<210> 1787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1787
tagaagagta tctattggtt 20
<210> 1788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1788
catctcaaaa catgctgtca 20
<210> 1789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1789
gagaagtaaa ataaggtttt 20
<210> 1790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1790
gagattcttc tttaatcact 20
<210> 1791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1791
ggagatttta cttaattttt 20
<210> 1792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1792
tacacaaaca acaatcatgt 20
<210> 1793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1793
ctcattaaga aatgtctaca 20
<210> 1794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1794
gactctctac cagagttgcg 20
<210> 1795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1795
atttggtttc aaaactacat 20
<210> 1796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1796
gggctatttt tataatgtga 20
<210> 1797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1797
gttcagacaa acagtaatta 20
<210> 1798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1798
acataatttg aatcctagga 20
<210> 1799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1799
tagcaaaata tcagatctta 20
<210> 1800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1800
ctggacagca aataagatag 20
<210> 1801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1801
tgttagaacc agtcaatcga 20
<210> 1802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1802
tagtccagcc ctgtggacaa 20
<210> 1803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1803
tgcagacatc cccaactgag 20
<210> 1804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1804
catatgcacc agtctcctgc 20
<210> 1805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1805
tgcaataacc tgattggttt 20
<210> 1806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1806
tcatcccttt aaaccacatt 20
<210> 1807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1807
tcccccaaac ctttcccaca 20
<210> 1808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1808
ttcaaaaccc acaaatgata 20
<210> 1809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1809
agggtaatga aattcgagga 20
<210> 1810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1810
tattttataa ttcctatacc 20
<210> 1811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1811
ggacatagta cagaggcaca 20
<210> 1812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1812
ggctcacaat tccaagttag 20
<210> 1813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1813
aataggtttc cttagtagtc 20
<210> 1814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1814
tgtatattta ttacttgatg 20
<210> 1815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1815
gtgcaatttt ttaaaacatt 20
<210> 1816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1816
gcaatggctt aagagtttag 20
<210> 1817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1817
tgcttaatat ccccacagct 20
<210> 1818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1818
aaggccttca gattggccac 20
<210> 1819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1819
tctggtagtg ccctcaaccc 20
<210> 1820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1820
tagacacacc acgattagaa 20
<210> 1821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1821
actcaatatt tttaaaaccc 20
<210> 1822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1822
gactgaatta tttatagttg 20
<210> 1823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1823
atgcaatttt aaattcatgt 20
<210> 1824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1824
gggaaaattc cttagcatat 20
<210> 1825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1825
gctgagttcc aaagcaaatt 20
<210> 1826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1826
atgacttacc aaaaaccatt 20
<210> 1827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1827
agggcttaaa tttaactgaa 20
<210> 1828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1828
aacgaaattc cttaaggaca 20
<210> 1829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1829
ttggttctat tttataatag 20
<210> 1830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1830
agactactat tttatcactg 20
<210> 1831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1831
tcacttaaac ccaggtcagc 20
<210> 1832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1832
ttccccaaaa tttagttgtg 20
<210> 1833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1833
cttcaactat tttatttggc 20
<210> 1834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1834
agtagaattt aaaagtagaa 20
<210> 1835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1835
ggatttctaa tttaatcttt 20
<210> 1836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1836
tagttctttc aaactccttt 20
<210> 1837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1837
gctataattc aaaatgctct 20
<210> 1838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1838
gcctaaacaa tttattcatt 20
<210> 1839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1839
acccttctat tttataaagc 20
<210> 1840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1840
tgcaagtttc aaaagaattc 20
<210> 1841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1841
aaggcatata ccactgtacc 20
<210> 1842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1842
tctaaccaat cctaaacccg 20
<210> 1843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1843
agaggtatag tctctcctag 20
<210> 1844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1844
tgactatttt caactcaagc 20
<210> 1845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1845
tattattatg ccatttattt 20
<210> 1846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1846
tcgcatttct aaacaaaacc 20
<210> 1847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1847
tttgaggaag cccttcccgg 20
<210> 1848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1848
gttttggaga aaaccatctc 20
<210> 1849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1849
ctaataaatt tttacaaggg 20
<210> 1850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1850
aaggaggctt cctttggtgc 20
<210> 1851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1851
aggcctttga tttatttttc 20
<210> 1852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1852
gatggaagcc aaaggctccc 20
<210> 1853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1853
aatgttacca ccgatgactc 20
<210> 1854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1854
tctgagagaa tcaaaacata 20
<210> 1855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1855
ctcacttgcc ttccttttct 20
<210> 1856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1856
tgcaatgttt aaaaatcatt 20
<210> 1857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1857
aacatttttt catgacacta 20
<210> 1858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1858
tcctttcacc acttagtcaa 20
<210> 1859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1859
tctgtctttc atctctggat 20
<210> 1860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1860
ccaatgaaaa taaactcatg 20
<210> 1861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1861
ccagagtcta aaagacttcc 20
<210> 1862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1862
ttctatttaa aataacaacc 20
<210> 1863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1863
gtatgggttc cttttccaaa 20
<210> 1864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1864
agttttaata aaagttcaac 20
<210> 1865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1865
ccatctcaaa acatgctgtc 20
<210> 1866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1866
atgtactttt tcccccttgg 20
<210> 1867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1867
tgggagattc ttctttaatc 20
<210> 1868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1868
tggagatttt acttaatttt 20
<210> 1869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1869
gataatatac acaaacaaca 20
<210> 1870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1870
tagactcatt aagaaatgtc 20
<210> 1871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1871
agactctcta ccagagttgc 20
<210> 1872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1872
tgtgtgacac tatttggttt 20
<210> 1873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1873
ctgggctatt tttataatgt 20
<210> 1874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1874
agacatgttc agacaaacag 20
<210> 1875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1875
acacataatt tgaatcctag 20
<210> 1876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1876
actagcaaaa tatcagatct 20
<210> 1877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1877
actttttttc ttatagtact 20
<210> 1878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1878
tctgttagaa ccagtcaatc 20
<210> 1879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1879
tcagactgcc catgttggcc 20
<210> 1880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1880
gagccgttct tcaggttctt 20
<210> 1881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1881
gcctggagcc ctgaccgctc 20
<210> 1882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1882
atgcaataac ctgattggtt 20
<210> 1883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1883
attcatccct ttaaaccaca 20
<210> 1884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1884
tcagtccccc aaacctttcc 20
<210> 1885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1885
gatgcattca aaacccacaa 20
<210> 1886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1886
tgactgcaag aatgagccca 20
<210> 1887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1887
caattatttt ataattccta 20
<210> 1888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1888
gtggacatag tacagaggca 20
<210> 1889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1889
aggctcacaa ttccaagtta 20
<210> 1890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1890
tggagatttt tctctctatg 20
<210> 1891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1891
ctgtatattt attacttgat 20
<210> 1892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1892
tcgacattca tttttctttt 20
<210> 1893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1893
atgtcaaaca tcatctctga 20
<210> 1894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1894
gggtgcttaa tatccccaca 20
<210> 1895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1895
gaaggccttc agattggcca 20
<210> 1896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1896
agtctggtag tgccctcaac 20
<210> 1897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1897
acaaatagac acaccacgat 20
<210> 1898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1898
gttgagttac aaatataaat 20
<210> 1899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1899
ccaggatttt aaaaaaagca 20
<210> 1900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1900
gctaaatttc cttaagcttt 20
<210> 1901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1901
catcagttcc aaaacctgga 20
<210> 1902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1902
ccaatacacc tttatttttc 20
<210> 1903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1903
cgattaatcc cttatgtttt 20
<210> 1904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1904
ctcttcaaaa acatatccga 20
<210> 1905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1905
ttctaaattt aaaactccaa 20
<210> 1906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1906
acaggcaata tttactataa 20
<210> 1907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1907
gccttcttcc tttatagcac 20
<210> 1908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1908
ttaggctatt aaataataga 20
<210> 1909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1909
ctcagtatct tttaattgcc 20
<210> 1910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1910
tgggccaaaa acaccccttt 20
<210> 1911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1911
ctgtttaaaa atgtattgag 20
<210> 1912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1912
gtcccttatc cttaacacac 20
<210> 1913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1913
ccctaaattt aaattctctg 20
<210> 1914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1914
acctttattt aaattttcca 20
<210> 1915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1915
gctcaatata tttatctatt 20
<210> 1916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1916
tctgtatttt aaaaatctct 20
<210> 1917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1917
cgagaaccct taatcctgcc 20
<210> 1918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1918
cgaaggcata taccactgta 20
<210> 1919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1919
ccactctaac caatcctaaa 20
<210> 1920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1920
ttttattttc tgatgctttg 20
<210> 1921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1921
catgactatt ttcaactcaa 20
<210> 1922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1922
gctgtattat tatgccattt 20
<210> 1923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1923
gtcgcatttc taaacaaaac 20
<210> 1924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1924
agtgacaaat cattggttgc 20
<210> 1925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1925
agtcacaatg ccatctgttt 20
<210> 1926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1926
gctaataaat ttttacaagg 20
<210> 1927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1927
tgctatcacc ctccactgaa 20
<210> 1928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1928
cttccataaa ctctttttag 20
<210> 1929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1929
cagatggaag ccaaaggctc 20
<210> 1930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1930
cagctaatcc attcaatgca 20
<210> 1931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1931
gctataaaca acaacagtct 20
<210> 1932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1932
cacggaagcc cttaggcaca 20
<210> 1933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1933
gagagaccca tttactgcaa 20
<210> 1934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1934
gttttacaaa acattttttc 20
<210> 1935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1935
aattcctttc accacttagt 20
<210> 1936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1936
ctctgtcttt catctctgga 20
<210> 1937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1937
cccaatgaaa ataaactcat 20
<210> 1938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1938
ctctttcccc aaactcagtg 20
<210> 1939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1939
gttctattta aaataacaac 20
<210> 1940
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1940
tataagcaaa ctgtatgggt 20
<210> 1941
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1941
tcaggctttc cagttttaat 20
<210> 1942
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1942
ctccatctca aaacatgctg 20
<210> 1943
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1943
caatgtactt tttccccctt 20
<210> 1944
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1944
aatgaaattt atgttaacct 20
<210> 1945
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1945
ttggagattt tacttaattt 20
<210> 1946
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1946
accgagataa tatacacaaa 20
<210> 1947
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1947
taggtaaact tatctgagga 20
<210> 1948
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1948
tcaggtgtta acatctgtct 20
<210> 1949
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1949
ctcatacaat tctagttacc 20
<210> 1950
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1950
gggaaagttt cattgttctg 20
<210> 1951
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1951
gcaaaaagat ccttccagaa 20
<210> 1952
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1952
gctaacagac acataatttg 20
<210> 1953
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1953
cactagcaaa atatcagatc 20
<210> 1954
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1954
aacttttttt cttatagtac 20
<210> 1955
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1955
ttcaaaatat tccatcaagt 20
<210> 1956
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1956
tcaccgttca ggacctcctt 20
<210> 1957
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1957
gcccttttta acagagccgt 20
<210> 1958
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1958
gccccgttcc tttcttcccc 20
<210> 1959
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1959
gggagtgaag tcaatgcaat 20
<210> 1960
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1960
cattcatccc tttaaaccac 20
<210> 1961
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1961
gttcagtccc ccaaaccttt 20
<210> 1962
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1962
agatgcattc aaaacccaca 20
<210> 1963
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1963
cagcactaaa taagcagtat 20
<210> 1964
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1964
accaattatt ttataattcc 20
<210> 1965
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1965
ctgtcggtaa atattgcaaa 20
<210> 1966
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1966
ctaacagaaa acatagaggc 20
<210> 1967
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1967
ttggagattt ttctctctat 20
<210> 1968
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1968
tctgtatatt tattacttga 20
<210> 1969
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1969
gccatatctt tcaaacactg 20
<210> 1970
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1970
aatgtcaaac atcatctctg 20
<210> 1971
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1971
aatttaagaa ttgtaagtgg 20
<210> 1972
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1972
aacgaaggcc ttcagattgg 20
<210> 1973
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1973
tagttctcct ctgtactggc 20
<210> 1974
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1974
ctacaaatag acacaccacg 20
<210> 1975
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1975
aacagtagcc aaaatgttct 20
<210> 1976
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1976
ctagaatttt aaaaaaccag 20
<210> 1977
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1977
agtacaatct tttatagata 20
<210> 1978
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1978
tgcctgagaa tttaatacta 20
<210> 1979
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1979
agtaagcttc tttaacttta 20
<210> 1980
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1980
tggataatta tttaattcat 20
<210> 1981
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1981
ccaaactaag aataatctag 20
<210> 1982
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1982
gaggaaatta tttactggct 20
<210> 1983
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1983
atgcacatac aaataagctc 20
<210> 1984
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1984
gagattaaaa tacaattgct 20
<210> 1985
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1985
gatttctcct tttaacctct 20
<210> 1986
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1986
ttctcaaaac cttatctcct 20
<210> 1987
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1987
cattttattc cttatcctac 20
<210> 1988
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1988
catttgcacc tttaatttgt 20
<210> 1989
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1989
ttccaaaaag aatgtgtccc 20
<210> 1990
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1990
ggtagctatc attattaagc 20
<210> 1991
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1991
cgacagaaaa tatatctgct 20
<210> 1992
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1992
gactgcaaaa ttcccattgc 20
<210> 1993
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1993
ctgtaaaaat acacatcctc 20
<210> 1994
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1994
cccgagaacc cttaatcctg 20
<210> 1995
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1995
cacaggttca gccatagctc 20
<210> 1996
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1996
tccactctaa ccaatcctaa 20
<210> 1997
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1997
cgcttttatt ttctgatgct 20
<210> 1998
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1998
tcatgactat tttcaactca 20
<210> 1999
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1999
agctgtatta ttatgccatt 20
<210> 2000
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2000
agtcgcattt ctaaacaaaa 20
<210> 2001
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2001
aagtgacaaa tcattggttg 20
<210> 2002
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2002
gcctagagtc acaatgccat 20
<210> 2003
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2003
cgctaataaa tttttacaag 20
<210> 2004
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2004
tcaaccagaa tcaaggcatg 20
<210> 2005
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2005
ctctccttcc ataaactctt 20
<210> 2006
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2006
gatgggataa tatagaacgc 20
<210> 2007
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2007
ccagctaatc cattcaatgc 20
<210> 2008
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2008
atgctataaa caacaacagt 20
<210> 2009
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2009
gacacggaag cccttaggca 20
<210> 2010
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2010
gcgagagacc catttactgc 20
<210> 2011
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2011
ggcatctgtt ttacaaaaca 20
<210> 2012
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2012
aataaaattc ctttcaccac 20
<210> 2013
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2013
ctttatactt ttgtaagctt 20
<210> 2014
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2014
tcccaatgaa aataaactca 20
<210> 2015
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2015
gcctctttcc ccaaactcag 20
<210> 2016
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2016
cagttctatt taaaataaca 20
<210> 2017
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2017
atcccaatta taagcaaact 20
<210> 2018
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2018
tttcaggctt tccagtttta 20
<210> 2019
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2019
tctccatctc aaaacatgct 20
<210> 2020
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2020
ctacctagac aatgtacttt 20
<210> 2021
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2021
cccacctggc ctgttaatga 20
<210> 2022
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2022
ccagcctaaa aaattggaga 20
<210> 2023
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2023
caccgagata atatacacaa 20
<210> 2024
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2024
actgtgttct cataggtaaa 20
<210> 2025
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2025
aagtcataaa aataaaactc 20
<210> 2026
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2026
actcatacaa ttctagttac 20
<210> 2027
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2027
agcatgaacc ccttctcctg 20
<210> 2028
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2028
agcaaaaaga tccttccaga 20
<210> 2029
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2029
atagagacaa aaagatggtc 20
<210> 2030
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2030
gcactagcaa aatatcagat 20
<210> 2031
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2031
tctggacaaa atgtttaaac 20
<210> 2032
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2032
aatattcaaa atattccatc 20
<210> 2033
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2033
ctcaccgttc aggacctcct 20
<210> 2034
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2034
tggccctttt taacagagcc 20
<210> 2035
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2035
agccccgttc ctttcttccc 20
<210> 2036
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2036
ttgcatctac ctcttgggag 20
<210> 2037
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2037
acattcatcc ctttaaacca 20
<210> 2038
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2038
gctacattta tttatgctcg 20
<210> 2039
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2039
gcactttaaa gatgcattca 20
<210> 2040
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2040
acagcactaa ataagcagta 20
<210> 2041
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2041
aaccaattat tttataattc 20
<210> 2042
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2042
gctgtcggta aatattgcaa 20
<210> 2043
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2043
acctaacaga aaacatagag 20
<210> 2044
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2044
agtgtcttca aaagcattgg 20
<210> 2045
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2045
tctctgtata tttattactt 20
<210> 2046
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2046
agccatatct ttcaaacact 20
<210> 2047
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2047
tctttgggtt tataggaaca 20
<210> 2048
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2048
ttctgaattt aagaattgta 20
<210> 2049
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2049
cacttccaac gaaggccttc 20
<210> 2050
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2050
ccctagttct cctctgtact 20
<210> 2051
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2051
gtatcctaca aatagacaca 20
<210> 2052
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2052
actcactatt tttaagagca 20
<210> 2053
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2053
ctgggaattt aaaaaacaaa 20
<210> 2054
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2054
tccataaaca tttatacaga 20
<210> 2055
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2055
ggttcaaaac cttagtcaga 20
<210> 2056
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2056
atagaatatt tttatcattc 20
<210> 2057
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2057
gaataaatta tttactgcgg 20
<210> 2058
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2058
ggtcaatttc aaactgttct 20
<210> 2059
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2059
ggcctaaaac tattcttgat 20
<210> 2060
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2060
acacttaaac ctgttaatat 20
<210> 2061
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2061
gctcataaaa tacctctcta 20
<210> 2062
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2062
ccaggaaaga tttatttagc 20
<210> 2063
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2063
agcacatttc aaaagttcag 20
<210> 2064
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2064
attcattttc cttatgttac 20
<210> 2065
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2065
tcacccaaac ccattgccta 20
<210> 2066
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2066
ttctgtaaaa tatatcctgt 20
<210> 2067
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2067
atctgtaaaa tatggttgca 20
<210> 2068
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2068
aacttatttt aaagtgtcca 20
<210> 2069
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2069
acattatacc cttaatatcc 20
<210> 2070
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2070
gctgtaaaaa tacacatcct 20
<210> 2071
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2071
gcttattttt tctagagaac 20
<210> 2072
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2072
agtgatagtc acaggttcag 20
<210> 2073
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2073
ttatccactc taaccaatcc 20
<210> 2074
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2074
ccacgctttt attttctgat 20
<210> 2075
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2075
cagctatttc atgactattt 20
<210> 2076
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2076
gagctgtatt attatgccat 20
<210> 2077
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2077
cagtcgcatt tctaaacaaa 20
<210> 2078
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2078
cggtaaagtg acaaatcatt 20
<210> 2079
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2079
ctgcctagag tcacaatgcc 20
<210> 2080
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2080
acgctaataa atttttacaa 20
<210> 2081
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2081
actctcaacc agaatcaagg 20
<210> 2082
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2082
cctctccttc cataaactct 20
<210> 2083
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2083
ctgtgtactc ttcagagaag 20
<210> 2084
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2084
accagctaat ccattcaatg 20
<210> 2085
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2085
aacaatagtc tttaattttt 20
<210> 2086
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2086
gtgagtgacc acagcagctg 20
<210> 2087
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2087
agcgagagac ccatttactg 20
<210> 2088
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2088
ctgttttcac aaattgcgaa 20
<210> 2089
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2089
caataaaatt cctttcacca 20
<210> 2090
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2090
gcctttatac ttttgtaagc 20
<210> 2091
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2091
gtttctgatt aaatcccaat 20
<210> 2092
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2092
tgcctctttc cccaaactca 20
<210> 2093
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2093
gagaactccc ctgacagttc 20
<210> 2094
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2094
acatcacaaa catcccaatt 20
<210> 2095
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2095
gatacatttc aggctttcca 20
<210> 2096
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2096
cttgaaattc ccttggagag 20
<210> 2097
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2097
aactacctag acaatgtact 20
<210> 2098
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2098
cgtactaaaa caagatgacg 20
<210> 2099
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2099
accagcctaa aaaattggag 20
<210> 2100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2100
gcaccgagat aatatacaca 20
<210> 2101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2101
tctgaaaata acatctactg 20
<210> 2102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2102
ccaagtcata aaaataaaac 20
<210> 2103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2103
atagccactc atacaattct 20
<210> 2104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2104
aagcatgaac cccttctcct 20
<210> 2105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2105
ggagcaaaaa gatccttcca 20
<210> 2106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2106
ggattctcta attagagctt 20
<210> 2107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2107
gaggagacca gatagcttgt 20
<210> 2108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2108
ctctggacaa aatgtttaaa 20
<210> 2109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2109
tcaatattca aaatattcca 20
<210> 2110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2110
gggcaggacc atcacagagg 20
<210> 2111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2111
ctggcccttt ttaacagagc 20
<210> 2112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2112
ctgcaggacc cttcccacgg 20
<210> 2113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2113
tcaaagacaa aaagatttcg 20
<210> 2114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2114
attcacattc atccctttaa 20
<210> 2115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2115
gttagaaaga aattttgcta 20
<210> 2116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2116
cctacttata aaactttttt 20
<210> 2117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2117
tacagcacta aataagcagt 20
<210> 2118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2118
cacatgctaa aaaagcaaga 20
<210> 2119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2119
aagaaagaac aaaagacggc 20
<210> 2120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2120
cacctaacag aaaacataga 20
<210> 2121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2121
tagtgtcttc aaaagcattg 20
<210> 2122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2122
agtatattct ctgtatattt 20
<210> 2123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2123
gagccatatc tttcaaacac 20
<210> 2124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2124
ttcaagatta tattctttgg 20
<210> 2125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2125
gttgccttca acgagaaggg 20
<210> 2126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2126
actgtaaaca acacttccaa 20
<210> 2127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2127
acatcattcc ttccctagtt 20
<210> 2128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2128
tgtatcctac aaatagacac 20
<210> 2129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2129
ggctgatttt aaacttagtt 20
<210> 2130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2130
gttttatatt tttaagtgct 20
<210> 2131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2131
acatttaaaa tatttcagac 20
<210> 2132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2132
tgtctatttt aaagactcaa 20
<210> 2133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2133
ggatatctat tttaattctt 20
<210> 2134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2134
acagtatttc aaaagaagcc 20
<210> 2135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2135
ctggataata cctaactgtc 20
<210> 2136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2136
agtgacttag attatccttt 20
<210> 2137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2137
cacatcaaac ctcaagggca 20
<210> 2138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2138
gtttccctaa tttatggagt 20
<210> 2139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2139
attcttacaa tttacttgta 20
<210> 2140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2140
attctctttt aaagataaag 20
<210> 2141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2141
ctatggtttt aaaattcatt 20
<210> 2142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2142
actaccagcc cttatttcag 20
<210> 2143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2143
ctctgctttc aaatgtgttt 20
<210> 2144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2144
tctttcatat tttaaagtgc 20
<210> 2145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2145
tccagtaaaa acacaacact 20
<210> 2146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2146
tataatatac attataccct 20
<210> 2147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2147
ccacaattac aaacacactt 20
<210> 2148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2148
ggcttatttt ttctagagaa 20
<210> 2149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2149
gcagtgatag tcacaggttc 20
<210> 2150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2150
ggaattatcc actctaacca 20
<210> 2151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2151
tgtattaacc acgcttttat 20
<210> 2152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2152
agcagctatt tcatgactat 20
<210> 2153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2153
gtgagctgta ttattatgcc 20
<210> 2154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2154
gcaaggaacc agtcgcattt 20
<210> 2155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2155
agccgatttc tgataggctc 20
<210> 2156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2156
gcaggatttc tgcctagagt 20
<210> 2157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2157
atgttcatct taatgctctt 20
<210> 2158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2158
gactctcaac cagaatcaag 20
<210> 2159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2159
tgcctctcct tccataaact 20
<210> 2160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2160
ttttacaact ccactgagca 20
<210> 2161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2161
ctcggctatt tttaggtacc 20
<210> 2162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2162
tgctttaaac aatagtcttt 20
<210> 2163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2163
ccagtgagtg accacagcag 20
<210> 2164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2164
accccgtctc aaagatgaag 20
<210> 2165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2165
ccctgttttc acaaattgcg 20
<210> 2166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2166
tcaataaaat tcctttcacc 20
<210> 2167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2167
ggcctttata cttttgtaag 20
<210> 2168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2168
tggtttctga ttaaatccca 20
<210> 2169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2169
tttacttgta tatttgtctg 20
<210> 2170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2170
ctgtcctttt cagagagaac 20
<210> 2171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2171
tacatcacaa acatcccaat 20
<210> 2172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2172
aatgatacat ttcaggcttt 20
<210> 2173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2173
atatatcatc aaatctgttg 20
<210> 2174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2174
ttagtgtgaa ctacctagac 20
<210> 2175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2175
ctgccgaaaa attcacgaga 20
<210> 2176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2176
aaccagccta aaaaattgga 20
<210> 2177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2177
aggataattt tatggcaccg 20
<210> 2178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2178
gcaatattta attttctgaa 20
<210> 2179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2179
tgctgcaaat ccaagtcata 20
<210> 2180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2180
ccttatagcc actcatacaa 20
<210> 2181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2181
agtacattca tatggcagct 20
<210> 2182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2182
ggcgaattct atatggagca 20
<210> 2183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2183
aactggattc tctaattaga 20
<210> 2184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2184
gcattcaatt taaaaaaggg 20
<210> 2185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2185
aataaattta aaaactctgg 20
<210> 2186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2186
atcaatattc aaaatattcc 20
<210> 2187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2187
ctgttgcacc tccaggtcag 20
<210> 2188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2188
gctggccctt tttaacagag 20
<210> 2189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2189
cctgtgcacc cccacatgcg 20
<210> 2190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2190
tgaactataa acagtactag 20
<210> 2191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2191
aattcacatt catcccttta 20
<210> 2192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2192
aaccttataa aatggcctag 20
<210> 2193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2193
tctccctact tataaaactt 20
<210> 2194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2194
atacagcact aaataagcag 20
<210> 2195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2195
ggtcagactc tattggcaca 20
<210> 2196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2196
ttactagttt aaaaatggaa 20
<210> 2197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2197
acacactcac ctaacagaaa 20
<210> 2198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2198
cttcctcacc catatctgaa 20
<210> 2199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2199
gctttataaa aaagtatatt 20
<210> 2200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2200
agagccatat ctttcaaaca 20
<210> 2201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2201
tgttcaagat tatattcttt 20
<210> 2202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2202
aacagttgcc ttcaacgaga 20
<210> 2203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2203
attactgtaa acaacacttc 20
<210> 2204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2204
aacatcattc cttccctagt 20
<210> 2205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2205
gagtgtatcc tacaaataga 20
<210> 2206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2206
tctagcaaac ctctttttcc 20
<210> 2207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2207
aggtataaat cccctttcca 20
<210> 2208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2208
gatagtaatc aaacctgagt 20
<210> 2209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2209
atttgtctat tttaaagact 20
<210> 2210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2210
atgagtaaaa tatggtcctt 20
<210> 2211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2211
cacttcataa tttaatattt 20
<210> 2212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2212
gtgatatttt aaagacttac 20
<210> 2213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2213
agggccttat tttaatcaca 20
<210> 2214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2214
catttatttc cttacccagt 20
<210> 2215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2215
gtgtctaaaa ccaactgggt 20
<210> 2216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2216
aagccaatat tttattttga 20
<210> 2217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2217
ggtgataaag atatcattac 20
<210> 2218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2218
ttcgaaattc tttatttgat 20
<210> 2219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2219
cactataaag aatgatgagt 20
<210> 2220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2220
tagagaaaac gatgttggct 20
<210> 2221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2221
ccttcggcta tttaataata 20
<210> 2222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2222
aggcatctaa tttaaattca 20
<210> 2223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2223
gcttgtaaaa ctatggcggc 20
<210> 2224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2224
ggcaataaaa tatttaatgg 20
<210> 2225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2225
gggcttattt tttctagaga 20
<210> 2226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2226
acattatata tatgttggag 20
<210> 2227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2227
actggaatta tccactctaa 20
<210> 2228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2228
attgtattaa ccacgctttt 20
<210> 2229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2229
tagcagctat ttcatgacta 20
<210> 2230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2230
gtgaacagcc actacagagg 20
<210> 2231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2231
ccttcattct caagctgaag 20
<210> 2232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2232
gatgtcagcc gatttctgat 20
<210> 2233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2233
aggcatcctc aagagtctgt 20
<210> 2234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2234
gtacatgttc atcttaatgc 20
<210> 2235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2235
ggactctcaa ccagaatcaa 20
<210> 2236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2236
gctgcctctc cttccataaa 20
<210> 2237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2237
caatacattt tacaactcca 20
<210> 2238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2238
ctgactctac aggctcatgt 20
<210> 2239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2239
ctgctttaaa caatagtctt 20
<210> 2240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2240
agggatggcc aggaaggaca 20
<210> 2241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2241
atcagaaaac cccgtctcaa 20
<210> 2242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2242
tccctgtttt cacaaattgc 20
<210> 2243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2243
ttcaataaaa ttcctttcac 20
<210> 2244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2244
atggccttta tacttttgta 20
<210> 2245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2245
acacattttc cagaatggtt 20
<210> 2246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2246
cttttttatt tacttgtata 20
<210> 2247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2247
cactgtcctt ttcagagaga 20
<210> 2248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2248
cttacatcac aaacatccca 20
<210> 2249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2249
ctaatgatac atttcaggct 20
<210> 2250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2250
atatatatca tcaaatctgt 20
<210> 2251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2251
ctcctcacta attagtgtga 20
<210> 2252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2252
gcctgccgaa aaattcacga 20
<210> 2253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2253
ccaaccagcc taaaaaattg 20
<210> 2254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2254
taggataatt ttatggcacc 20
<210> 2255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2255
caggcaatat ttaattttct 20
<210> 2256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2256
ttgctgcaaa tccaagtcat 20
<210> 2257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2257
tgccttatag ccactcatac 20
<210> 2258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2258
tgagtacatt catatggcag 20
<210> 2259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2259
tggcgaattc tatatggagc 20
<210> 2260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2260
agttgaatag acatggatta 20
<210> 2261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2261
actttcacaa ttttgcaaat 20
<210> 2262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2262
tctgaacaaa aatataagca 20
<210> 2263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2263
aaggtcatca atattcaaaa 20
<210> 2264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2264
aggcttccct aaatgcaggc 20
<210> 2265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2265
ggccgtcggc ctttgagtgc 20
<210> 2266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2266
aggcagagaa aaagagaccc 20
<210> 2267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2267
agtcatgaac tataaacagt 20
<210> 2268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2268
ataattcaca ttcatccctt 20
<210> 2269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2269
aacataacct tataaaatgg 20
<210> 2270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2270
ttctccctac ttataaaact 20
<210> 2271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2271
cgtttaaaaa atacagcact 20
<210> 2272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2272
gctttaacta tatagcacac 20
<210> 2273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2273
gcctgctgtt actagtttaa 20
<210> 2274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2274
aacacactca cctaacagaa 20
<210> 2275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2275
ctctgcttcc tcacccatat 20
<210> 2276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2276
tgctttataa aaaagtatat 20
<210> 2277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2277
ttcaacagag ccatatcttt 20
<210> 2278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2278
gtgttcaaga ttatattctt 20
<210> 2279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2279
gttagctacc agaacagttg 20
<210> 2280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2280
gtaaggatta ctgtaaacaa 20
<210> 2281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2281
caaaacatca ttccttccct 20
<210> 2282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2282
cgagtgtatc ctacaaatag 20
<210> 2283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2283
tgccagagaa tttatatgta 20
<210> 2284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2284
cctgtcaaaa ccagtcactc 20
<210> 2285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2285
ctaataatag tctaattaca 20
<210> 2286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2286
ttgtgctttt aaattcaaac 20
<210> 2287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2287
acatcctttt aaatgttagg 20
<210> 2288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2288
tgtcttaatc aaacctcccg 20
<210> 2289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2289
cagttctatt tttagttata 20
<210> 2290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2290
atttaccttc tttaacacaa 20
<210> 2291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2291
gggatatttt aaaattctac 20
<210> 2292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2292
cctgggtttc aaagattcct 20
<210> 2293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2293
tagagaattc aaagcaccaa 20
<210> 2294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2294
tcaaagtttt aaagagtttt 20
<210> 2295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2295
tgctccaaac ccagctcctc 20
<210> 2296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2296
ccctactcct tttatagatg 20
<210> 2297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2297
tcatccaaac ccagacgggt 20
<210> 2298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2298
ataaagtcct tttaacccct 20
<210> 2299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2299
gtgccctttt aaaatctttt 20
<210> 2300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2300
agccaaaaat acatccacct 20
<210> 2301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2301
actgtaatct aaacaggcaa 20
<210> 2302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2302
ttcattacac acagcagaga 20
<210> 2303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2303
agacattata tatatgttgg 20
<210> 2304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2304
cccctacacc ccagagcaca 20
<210> 2305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2305
gattgtatta accacgcttt 20
<210> 2306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2306
tgaatgtccc aaatagcagc 20
<210> 2307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2307
cacccctaat tcatgcagga 20
<210> 2308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2308
gccttcattc tcaagctgaa 20
<210> 2309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2309
tttagctgtg atgatgtcag 20
<210> 2310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2310
tcaggcatcc tcaagagtct 20
<210> 2311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2311
ctttagttcc catgaggtct 20
<210> 2312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2312
aagtggatta tatttggcag 20
<210> 2313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2313
atcagctgcc tctccttcca 20
<210> 2314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2314
ccaatacatt ttacaactcc 20
<210> 2315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2315
ggactgactc tacaggctca 20
<210> 2316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2316
actgctttaa acaatagtct 20
<210> 2317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2317
tttttcttac acatggtagc 20
<210> 2318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2318
tcagcatgaa aaaaatcaga 20
<210> 2319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2319
agtccctgtt ttcacaaatt 20
<210> 2320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2320
gcttttaaga aaaattttag 20
<210> 2321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2321
ggatggcctt tatacttttg 20
<210> 2322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2322
tcattttatg atcttgctgg 20
<210> 2323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2323
ctggttatct tcttatgcat 20
<210> 2324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2324
tttggaatct tttttgcctc 20
<210> 2325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2325
ctcttacatc acaaacatcc 20
<210> 2326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2326
gttcctaatg atacatttca 20
<210> 2327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2327
aatatatatc atcaaatctg 20
<210> 2328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2328
ttttctcctc actaattagt 20
<210> 2329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2329
agcctgccga aaaattcacg 20
<210> 2330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2330
ccataaaaac cctccaacca 20
<210> 2331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2331
ctaggataat tttatggcac 20
<210> 2332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2332
gcaggcaata tttaattttc 20
<210> 2333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2333
ggaaaccaat cccacatcaa 20
<210> 2334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2334
agtgtttgcc ttatagccac 20
<210> 2335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2335
ttgagtacat tcatatggca 20
<210> 2336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2336
tgctaaagaa aaagaattgt 20
<210> 2337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2337
tttccagttg aatagacatg 20
<210> 2338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2338
aattactttc acaattttgc 20
<210> 2339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2339
ctctgaacaa aaatataagc 20
<210> 2340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2340
acacactata aatgaggctc 20
<210> 2341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2341
caggcttccc taaatgcagg 20
<210> 2342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2342
gctgcccgcc aggccgtcgg 20
<210> 2343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2343
cccccccggc ccatgccgat 20
<210> 2344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2344
tagtcatgaa ctataaacag 20
<210> 2345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2345
tcataattca cattcatccc 20
<210> 2346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2346
gaccaaaatg aattttcaaa 20
<210> 2347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2347
tatttaaaaa tttctcccta 20
<210> 2348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2348
tcttaccatc aaaggctaaa 20
<210> 2349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2349
agctttaact atatagcaca 20
<210> 2350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2350
cctgactaat ttcttggtga 20
<210> 2351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2351
aaaacccaac acactcacct 20
<210> 2352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2352
gacaaccaac acagctcaag 20
<210> 2353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2353
gtgctttata aaaaagtata 20
<210> 2354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2354
tcattgtttc aacagagcca 20
<210> 2355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2355
cgtgttcaag attatattct 20
<210> 2356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2356
agttagctac cagaacagtt 20
<210> 2357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2357
tgtcacctaa tacttggtat 20
<210> 2358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2358
gtgcaaaaca tcattccttc 20
<210> 2359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2359
aattcaataa acagactcga 20
<210> 2360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2360
ttcagaattt aaaattcagc 20
<210> 2361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2361
acaattagcc aaaactgaat 20
<210> 2362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2362
cgttccaaat tattcctgct 20
<210> 2363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2363
atttgctcct tttatcattg 20
<210> 2364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2364
acattatttc aaaacccaca 20
<210> 2365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2365
tagtggttag attaacagct 20
<210> 2366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2366
gtctcataac gataaccaaa 20
<210> 2367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2367
acctttaaaa ttttttcagc 20
<210> 2368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2368
gcttacaaag ccatagaacc 20
<210> 2369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2369
gtctacagcc tttaacgact 20
<210> 2370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2370
ccagttaacc aaaaaatttt 20
<210> 2371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2371
ggctactatc aaatacattt 20
<210> 2372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2372
tgtttatttc aaactttccc 20
<210> 2373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2373
ggtcttggcc cttaactgtt 20
<210> 2374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2374
ccctgataaa tttatgaatt 20
<210> 2375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2375
tttgatctgc cttatctctg 20
<210> 2376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2376
tttgtatttt aaactgagtg 20
<210> 2377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2377
aagccaaaaa tacatccacc 20
<210> 2378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2378
ctttttagaa taccatgccc 20
<210> 2379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2379
aattcattac acacagcaga 20
<210> 2380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2380
aagacattat atatatgttg 20
<210> 2381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2381
aaggacagcc cctacacccc 20
<210> 2382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2382
cagattgtat taaccacgct 20
<210> 2383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2383
tgttttattt tatctgaatg 20
<210> 2384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2384
ccacccctaa ttcatgcagg 20
<210> 2385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2385
gctgccttca ttctcaagct 20
<210> 2386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2386
ggtggagtat tttagctgtg 20
<210> 2387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2387
ttatgagttc aggcatcctc 20
<210> 2388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2388
ggctttagtt cccatgaggt 20
<210> 2389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2389
ttaagtggat tatatttggc 20
<210> 2390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2390
ctagactttc atcagctgcc 20
<210> 2391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2391
accaatacat tttacaactc 20
<210> 2392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2392
aagggactga ctctacaggc 20
<210> 2393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2393
gacctctctc tacttgctgt 20
<210> 2394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2394
tgggtttttc ttacacatgg 20
<210> 2395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2395
gtcttgtttt acctgtagag 20
<210> 2396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2396
catttccttc acaagagtcc 20
<210> 2397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2397
cctaatctga ctaatgactg 20
<210> 2398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2398
agggatggcc tttatacttt 20
<210> 2399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2399
aatcattaag tcattttatg 20
<210> 2400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2400
actggttatc ttcttatgca 20
<210> 2401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2401
actctctcca ttcatttgga 20
<210> 2402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2402
tctcttacat cacaaacatc 20
<210> 2403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2403
tgagggttcc taatgataca 20
<210> 2404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2404
gtgagaatat atatcatcaa 20
<210> 2405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2405
cttgccagcc caatgctagt 20
<210> 2406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2406
catagctaga acagcctgcc 20
<210> 2407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2407
cccataaaaa ccctccaacc 20
<210> 2408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2408
gctaggataa ttttatggca 20
<210> 2409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2409
tatacacact tcacagggca 20
<210> 2410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2410
cagaaggaaa ccaatcccac 20
<210> 2411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2411
cagtgtttgc cttatagcca 20
<210> 2412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2412
aacttgagta cattcatatg 20
<210> 2413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2413
tggaatatct ttacagtgct 20
<210> 2414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2414
cactgaaatc aagaatgcaa 20
<210> 2415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2415
tgaattactt tcacaatttt 20
<210> 2416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2416
aactctgaac aaaaatataa 20
<210> 2417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2417
agccacacac tataaatgag 20
<210> 2418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2418
ccaggcttcc ctaaatgcag 20
<210> 2419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2419
attccgtttt cctgctcggc 20
<210> 2420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2420
ctgctctgaa cccccccggc 20
<210> 2421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2421
ttgtccatag tcatgaacta 20
<210> 2422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2422
ttcataattc acattcatcc 20
<210> 2423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2423
gatgtggtaa aaagaccaaa 20
<210> 2424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2424
atatttaaaa atttctccct 20
<210> 2425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2425
cctcttacca tcaaaggcta 20
<210> 2426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2426
gagctttaac tatatagcac 20
<210> 2427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2427
ttcgccctga ctaatttctt 20
<210> 2428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2428
ggatgctgcc acttcctggt 20
<210> 2429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2429
ccatgacaac caacacagct 20
<210> 2430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2430
ccaacccaac acaatagcag 20
<210> 2431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2431
actcattgtt tcaacagagc 20
<210> 2432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2432
cccttgttac aaacacttcg 20
<210> 2433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2433
ccctcccgcc attacacagg 20
<210> 2434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2434
tagtgtcacc taatacttgg 20
<210> 2435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2435
ggtgcaaaac atcattcctt 20
<210> 2436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2436
ccataaaatt caataaacag 20
<210> 2437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2437
ataagctttc tttaaatgca 20
<210> 2438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2438
gtgttctttc tttaacagtt 20
<210> 2439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2439
cccccgttcc aaattattcc 20
<210> 2440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2440
gtttttatcc attacaagag 20
<210> 2441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2441
acccgcaatc aaatactgcc 20
<210> 2442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2442
ctaatgtgcc cttaacatgg 20
<210> 2443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2443
gctcataaaa ccatgtgctc 20
<210> 2444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2444
gcttgatttt aaactttata 20
<210> 2445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2445
accctcaaac gaataggctc 20
<210> 2446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2446
tccacacaag aataatctac 20
<210> 2447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2447
gctaggaaaa tttaccatac 20
<210> 2448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2448
gattaaataa tttaagcaca 20
<210> 2449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2449
tcttgggttc cttatattac 20
<210> 2450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2450
taggtgttta tttagaaccc 20
<210> 2451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2451
tcatgctttc aaaacacagt 20
<210> 2452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2452
aatgaaatca tttactgaac 20
<210> 2453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2453
agtgtaatac attactcata 20
<210> 2454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2454
gtatacaaag atataacctg 20
<210> 2455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2455
tgtttgtttt aaaattaggg 20
<210> 2456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2456
ggttaattca ttacacacag 20
<210> 2457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2457
acctaaataa taagacatta 20
<210> 2458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2458
agccagacaa ctaaggacag 20
<210> 2459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2459
tcagattgta ttaaccacgc 20
<210> 2460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2460
ttgttttatt ttatctgaat 20
<210> 2461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2461
gtacccaccc ctaattcatg 20
<210> 2462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2462
tggctgcctt cattctcaag 20
<210> 2463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2463
tgtggcaaac acagctggtg 20
<210> 2464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2464
atactatatc acactgcttt 20
<210> 2465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2465
gttttatatg ccatggcttt 20
<210> 2466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2466
tggaggatat taagtggatt 20
<210> 2467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2467
tctagacttt catcagctgc 20
<210> 2468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2468
ttaccaatac attttacaac 20
<210> 2469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2469
ggcatgttca atgttggcaa 20
<210> 2470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2470
acagggaaaa ctgttaggtg 20
<210> 2471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2471
ctgggttttt cttacacatg 20
<210> 2472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2472
cagtcttgtt ttacctgtag 20
<210> 2473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2473
ctcccatttc cttcacaaga 20
<210> 2474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2474
gtcaccttcc taatctgact 20
<210> 2475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2475
cctttataac ttttctttct 20
<210> 2476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2476
gttagtaatc attaagtcat 20
<210> 2477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2477
ccctggtgcc aaaagggact 20
<210> 2478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2478
tctttaaccc ctcttgcgcc 20
<210> 2479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2479
tttctcttac atcacaaaca 20
<210> 2480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2480
ttgagggttc ctaatgatac 20
<210> 2481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2481
agtgagaata tatatcatca 20
<210> 2482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2482
aatctgatca ttgtaggcac 20
<210> 2483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2483
tggtgtgaac catagctaga 20
<210> 2484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2484
acccccctcc cataaaaacc 20
<210> 2485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2485
ggttttaccc tttcctgcac 20
<210> 2486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2486
cacattatac acacttcaca 20
<210> 2487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2487
tcattaacaa cataaactga 20
<210> 2488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2488
catggtacag ataattgtga 20
<210> 2489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2489
tactggatcc atacaaggca 20
<210> 2490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2490
atggaatatc tttacagtgc 20
<210> 2491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2491
ccactgaaat caagaatgca 20
<210> 2492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2492
tcttgaatta ctttcacaat 20
<210> 2493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2493
gaggacaact aaaaactctg 20
<210> 2494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2494
cagccacaca ctataaatga 20
<210> 2495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2495
gccaggcttc cctaaatgca 20
<210> 2496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2496
tcgccattct cagagagcat 20
<210> 2497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2497
tgggaacccc aggaggacac 20
<210> 2498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2498
atctaattcc tcatgtcaca 20
<210> 2499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2499
gttcataatt cacattcatc 20
<210> 2500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2500
cagagtttct aagagcccgc 20
<210> 2501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2501
aatatttaaa aatttctccc 20
<210> 2502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2502
ttcctcttac catcaaaggc 20
<210> 2503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2503
atgagcttta actatatagc 20
<210> 2504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2504
tcttttcgcc ctgactaatt 20
<210> 2505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2505
aagaggtgtg aaaggttccg 20
<210> 2506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2506
gccatgacaa ccaacacagc 20
<210> 2507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2507
ggaaaccaac ccaacacaat 20
<210> 2508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2508
actttcaacc cttctctgct 20
<210> 2509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2509
atcccttgtt acaaacactt 20
<210> 2510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2510
tccctcccgc cattacacag 20
<210> 2511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2511
tgagctagtg tcacctaata 20
<210> 2512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2512
aggtgcaaaa catcattcct 20
<210> 2513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2513
agggaccata aaattcaata 20
<210> 2514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2514
ctcctccaaa tttatcttca 20
<210> 2515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2515
cacaaaatac attaagtcct 20
<210> 2516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2516
tccagcaaaa tatttcttta 20
<210> 2517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2517
ttgatcaacc aaagatggct 20
<210> 2518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2518
ccaatggctt tttaacagat 20
<210> 2519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2519
aacacattag attatgagta 20
<210> 2520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2520
agggtgttat tttagagtaa 20
<210> 2521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2521
gctggaaaag aatctgagca 20
<210> 2522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2522
gttatattat tttatccctt 20
<210> 2523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2523
gaagatatct tttatgacac 20
<210> 2524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2524
cacagtagcc aaaagcagtc 20
<210> 2525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2525
gtatatatta tttaaaatgt 20
<210> 2526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2526
agctggtttc tttagccacc 20
<210> 2527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2527
gactgaaaaa tacccagcca 20
<210> 2528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2528
taggccttat tttattccat 20
<210> 2529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2529
tgagcttttt aaaaacagtt 20
<210> 2530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2530
tttcttagcc aaagagatat 20
<210> 2531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2531
tgttcaattt aaaagccttg 20
<210> 2532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2532
atctgcaaag aatctgcccc 20
<210> 2533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2533
aggttaattc attacacaca 20
<210> 2534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2534
tcatacctaa ataataagac 20
<210> 2535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2535
cagccagaca actaaggaca 20
<210> 2536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2536
cctgacttct cagattgtat 20
<210> 2537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2537
attcaaacca ttaattagtt 20
<210> 2538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2538
agtacccacc cctaattcat 20
<210> 2539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2539
agtggctgcc ttcattctca 20
<210> 2540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2540
gactctgaac ctgtcacttg 20
<210> 2541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2541
ccatactata tcacactgct 20
<210> 2542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2542
ctcagtttta tatgccatgg 20
<210> 2543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2543
ttggaggata ttaagtggat 20
<210> 2544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2544
ttctagactt tcatcagctg 20
<210> 2545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2545
ctttaccaat acattttaca 20
<210> 2546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2546
attcatcgcc accaagctcg 20
<210> 2547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2547
atctatcaca ccaatgcaag 20
<210> 2548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2548
gctgggtttt tcttacacat 20
<210> 2549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2549
agtgaaattc tcagtcttgt 20
<210> 2550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2550
gttgtttaaa tatgtctccc 20
<210> 2551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2551
tgtcaccttc ctaatctgac 20
<210> 2552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2552
gcctttataa cttttctttc 20
<210> 2553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2553
tgttagtaat cattaagtca 20
<210> 2554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2554
ccaaaaaatc ttcttccatg 20
<210> 2555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2555
ttctttaacc cctcttgcgc 20
<210> 2556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2556
cttggaatca tactttcttc 20
<210> 2557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2557
attgagggtt cctaatgata 20
<210> 2558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2558
tcagtgagaa tatatatcat 20
<210> 2559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2559
cagataatct gatcattgta 20
<210> 2560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2560
gtggtgtgaa ccatagctag 20
<210> 2561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2561
ccccccatac ccccctccca 20
<210> 2562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2562
gggttttacc ctttcctgca 20
<210> 2563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2563
gccacattat acacacttca 20
<210> 2564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2564
gtcattaaca acataaactg 20
<210> 2565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2565
ccatggtaca gataattgtg 20
<210> 2566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2566
ctgatacatt tctagaatga 20
<210> 2567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2567
tcacagttta catctcaaca 20
<210> 2568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2568
tagaattaaa atatacacca 20
<210> 2569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2569
gtcttgaatt actttcacaa 20
<210> 2570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2570
tggaccaacc ctccttctga 20
<210> 2571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2571
tcccccagcc acacactata 20
<210> 2572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2572
tcaggtagcc gatgacaggg 20
<210> 2573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2573
ttcgccattc tcagagagca 20
<210> 2574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2574
gctgggttcc tgatgttgat 20
<210> 2575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2575
aatctaattc ctcatgtcac 20
<210> 2576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2576
agttcataat tcacattcat 20
<210> 2577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2577
tcagagtttc taagagcccg 20
<210> 2578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2578
gcagccatcc aagtaagaat 20
<210> 2579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2579
gcccgtattc ctcttaccat 20
<210> 2580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2580
ggaagatcaa ccaaacaagg 20
<210> 2581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2581
gtattatttt tttcttttcg 20
<210> 2582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2582
cagagcagtc aaagtgctgc 20
<210> 2583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2583
agccatgaca accaacacag 20
<210> 2584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2584
aagagaggaa accaacccaa 20
<210> 2585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2585
aactttcaac ccttctctgc 20
<210> 2586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2586
ataatgagtc ctgtttgatt 20
<210> 2587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2587
ccggtgttcc ctcccgccat 20
<210> 2588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2588
cagagaaaac ctgtgcaccg 20
<210> 2589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2589
aaggtgcaaa acatcattcc 20
<210> 2590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2590
aagcaccatc aaagaaaggg 20
<210> 2591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2591
acccaatttc aaagatcact 20
<210> 2592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2592
gttcacaaaa tacattaagt 20
<210> 2593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2593
agatcaattc aaaggctcct 20
<210> 2594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2594
gatttgtatt tttaattgac 20
<210> 2595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2595
ttgacatttt aaaacagctc 20
<210> 2596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2596
aagcttatcc aaaaacattt 20
<210> 2597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2597
cccctcaacc aaacttttac 20
<210> 2598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2598
tattaatttc attaccatga 20
<210> 2599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2599
cctagaatac attattcctc 20
<210> 2600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2600
agcatatttt aaagaagaag 20
<210> 2601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2601
gtccatacac cttaataagt 20
<210> 2602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2602
gattactttt aaaagcaaca 20
<210> 2603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2603
cctaaaagaa tttatccata 20
<210> 2604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2604
cttggcaaat tattatctgc 20
<210> 2605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2605
gctaagaaaa tataggcctt 20
<210> 2606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2606
ggctttatag tctaagttgc 20
<210> 2607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2607
acttcaaacc tttatcagtt 20
<210> 2608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2608
caaacccaaa tttagctctg 20
<210> 2609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2609
cctttaagcc cttaaagctg 20
<210> 2610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2610
gaggttaatt cattacacac 20
<210> 2611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2611
ggccttatca tacctaaata 20
<210> 2612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2612
accagcagcc agacaactaa 20
<210> 2613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2613
taccccaagc ccagcaggtc 20
<210> 2614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2614
ccaaaacaat tcaaaccatt 20
<210> 2615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2615
tttctcctag tacccacccc 20
<210> 2616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2616
aagtggctgc cttcattctc 20
<210> 2617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2617
ggaacctcaa ttaagtccag 20
<210> 2618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2618
caccatacta tatcacactg 20
<210> 2619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2619
cctcagtttt atatgccatg 20
<210> 2620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2620
ttatggcctc aaacttggag 20
<210> 2621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2621
tctttctaga ctttcatcag 20
<210> 2622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2622
cactttacca atacatttta 20
<210> 2623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2623
ttaggattca tcgccaccaa 20
<210> 2624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2624
ccaatctatc acaccaatgc 20
<210> 2625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2625
tcccacatta aaagctgggt 20
<210> 2626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2626
tctgcaagtg aaattctcag 20
<210> 2627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2627
gtacatatca ccaaaaacaa 20
<210> 2628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2628
atgtcacctt cctaatctga 20
<210> 2629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2629
aatagccttt ataacttttc 20
<210> 2630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2630
tgtgttagta atcattaagt 20
<210> 2631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2631
ctgccaaaaa atcttcttcc 20
<210> 2632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2632
tgctggttct ttaacccctc 20
<210> 2633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2633
gctgttcaat caagcacctt 20
<210> 2634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2634
ctcaaaatat tattgagggt 20
<210> 2635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2635
tctcagtgag aatatatatc 20
<210> 2636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2636
tcagataatc tgatcattgt 20
<210> 2637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2637
cttagaatta aatgctgtgg 20
<210> 2638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2638
gtctcccccc atacccccct 20
<210> 2639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2639
aactccaaag acaccactct 20
<210> 2640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2640
agccacatta tacacacttc 20
<210> 2641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2641
tcttagagtc attaacaaca 20
<210> 2642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2642
tgggcttgtt ccatggtaca 20
<210> 2643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2643
tctgatacat ttctagaatg 20
<210> 2644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2644
actcacagtt tacatctcaa 20
<210> 2645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2645
gtagaattaa aatatacacc 20
<210> 2646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2646
aggtcttgaa ttactttcac 20
<210> 2647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2647
ttggaccaac cctccttctg 20
<210> 2648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2648
tttgcaaacc tccctctccc 20
<210> 2649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2649
gctcaggtag ccgatgacag 20
<210> 2650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2650
tcagttcgcc attctcagag 20
<210> 2651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2651
agctgggttc ctgatgttga 20
<210> 2652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2652
caaaatctaa ttcctcatgt 20
<210> 2653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2653
tagttcataa ttcacattca 20
<210> 2654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2654
ctcagagttt ctaagagccc 20
<210> 2655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2655
agttgcagcc atccaagtaa 20
<210> 2656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2656
agcccgtatt cctcttacca 20
<210> 2657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2657
gggaagatca accaaacaag 20
<210> 2658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2658
ggtttcttat taatagtatt 20
<210> 2659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2659
acaaccctac tccagagcag 20
<210> 2660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2660
aacagtagcc atgacaacca 20
<210> 2661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2661
tgccagaaac acaacactgt 20
<210> 2662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2662
catgtaactt tcaacccttc 20
<210> 2663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2663
ttttgtcccc ataatgagtc 20
<210> 2664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2664
acatgaaaaa ctgaagccgg 20
<210> 2665
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2665
cctgggccag aaaactgaaa 20
<210> 2666
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2666
tttcttttca ataaggtgca 20
<210> 2667
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2667
ctagaaaacc tgcaagcacc 20
<210> 2668
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2668
gctgaatttc aaacgcagca 20
<210> 2669
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2669
gcagtaattt aaagtatgaa 20
<210> 2670
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2670
aacaaatttt aaagctcttt 20
<210> 2671
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2671
agcatcaacc aaattcagta 20
<210> 2672
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2672
ccctgaccta tttaacatac 20
<210> 2673
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2673
ctgtttaacc aaaaacatct 20
<210> 2674
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2674
atcactaaac gatagcacaa 20
<210> 2675
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2675
aactcctttt aaattgaatt 20
<210> 2676
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2676
gggattaaat aattatgtgc 20
<210> 2677
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2677
gctagcatat tttaaagaag 20
<210> 2678
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2678
ccagcatttc aaagagcaac 20
<210> 2679
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2679
ggcatgttta tataacagcc 20
<210> 2680
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2680
ttcctaaaag aatttatcca 20
<210> 2681
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2681
gtttcaatat tttatgcaaa 20
<210> 2682
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2682
gcagtaataa tttagccaaa 20
<210> 2683
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2683
gctattagac aatatagagt 20
<210> 2684
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2684
cacttcaaac ctttatcagt 20
<210> 2685
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2685
aatcctttaa tttaacaacc 20
<210> 2686
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2686
ccatgaagaa tttaacctca 20
<210> 2687
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2687
ggaggttaat tcattacaca 20
<210> 2688
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2688
tggccttatc atacctaaat 20
<210> 2689
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2689
attgatcacc ccagcaccag 20
<210> 2690
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2690
ttaccccaag cccagcaggt 20
<210> 2691
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2691
cccaaaacaa ttcaaaccat 20
<210> 2692
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2692
attttctttc tcctagtacc 20
<210> 2693
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2693
agaggctgcc aggcctggga 20
<210> 2694
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2694
tggaacctca attaagtcca 20
<210> 2695
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2695
accaccatac tatatcacac 20
<210> 2696
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2696
ccctcagttt tatatgccat 20
<210> 2697
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2697
acttatggcc tcaaacttgg 20
<210> 2698
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2698
aagttcagcc ttctttctag 20
<210> 2699
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2699
agcactttac caatacattt 20
<210> 2700
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2700
actatctatt ttttgataca 20
<210> 2701
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2701
gtaaccaatc tatcacacca 20
<210> 2702
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2702
atcccacatt aaaagctggg 20
<210> 2703
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2703
gcattcttaa ctttgtctgc 20
<210> 2704
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2704
gtgctatgtc tatatacaca 20
<210> 2705
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2705
gggctcataa ttatttttta 20
<210> 2706
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2706
gaatagcctt tataactttt 20
<210> 2707
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2707
tcagttattt tctctccact 20
<210> 2708
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2708
cctgccaaaa aatcttcttc 20
<210> 2709
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2709
ttgctggttc tttaacccct 20
<210> 2710
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2710
cggctgttca atcaagcacc 20
<210> 2711
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2711
cctcaaaata ttattgaggg 20
<210> 2712
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2712
tgaagaaatc tcactgaggg 20
<210> 2713
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2713
agattattca gataatctga 20
<210> 2714
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2714
ccttagaatt aaatgctgtg 20
<210> 2715
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2715
tcctcgatac taaccccttc 20
<210> 2716
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2716
tcaaaactcc aaagacacca 20
<210> 2717
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2717
gagccacatt atacacactt 20
<210> 2718
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2718
cctcttagag tcattaacaa 20
<210> 2719
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2719
agtaggatcc aaaggcatga 20
<210> 2720
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2720
gttctgatac atttctagaa 20
<210> 2721
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2721
gaactcacag tttacatctc 20
<210> 2722
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2722
tgtagaatta aaatatacac 20
<210> 2723
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2723
tgagtcccta aaactggatt 20
<210> 2724
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2724
tcctttctag atgtagtaga 20
<210> 2725
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2725
gtttgcaaac ctccctctcc 20
<210> 2726
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2726
ggagcctttc atgaagtagg 20
<210> 2727
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2727
tctggaaact tcagttcgcc 20
<210> 2728
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2728
ttaactttcc aaatctgcca 20
<210> 2729
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2729
cttcaaaatc taattcctca 20
<210> 2730
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2730
tactagttca taattcacat 20
<210> 2731
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2731
tctcagagtt tctaagagcc 20
<210> 2732
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2732
atttgttcag tttagttgca 20
<210> 2733
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2733
gagaacaaag tctatgtggc 20
<210> 2734
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2734
ggctccttcc ctccagccct 20
<210> 2735
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2735
ttggtttctt attaatagta 20
<210> 2736
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2736
ttgtacaacc ctactccaga 20
<210> 2737
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2737
ggttcatgaa acagtagcca 20
<210> 2738
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2738
tatgccagaa acacaacact 20
<210> 2739
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2739
acatgtaact ttcaaccctt 20
<210> 2740
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2740
tttttgtccc cataatgagt 20
<210> 2741
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2741
gggacatgaa aaactgaagc 20
<210> 2742
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2742
aggatttacc ccactcctgg 20
<210> 2743
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2743
attttctttt caataaggtg 20
<210> 2744
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2744
tctacctaga aaacctgcaa 20
<210> 2745
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2745
ctcacatttt aaagagtctg 20
<210> 2746
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2746
tcactgaacc cttatttttt 20
<210> 2747
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2747
actagaaaag ccacccttct 20
<210> 2748
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2748
agtctgtata tttatattta 20
<210> 2749
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2749
cctttgtttt aaaataggta 20
<210> 2750
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2750
aatgccaaag atatacgcca 20
<210> 2751
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2751
agttaatatc cttaatacaa 20
<210> 2752
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2752
aagtactatc attattgcat 20
<210> 2753
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2753
ttccccttat tttattcata 20
<210> 2754
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2754
ttccttctag attaaagact 20
<210> 2755
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2755
aacacaattt aaattgagtt 20
<210> 2756
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2756
cctaagtacc cttaattttt 20
<210> 2757
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2757
tgtctatttc aaagaagcga 20
<210> 2758
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2758
cacacaattc aaaacttgaa 20
<210> 2759
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2759
agcagaatct aaatcgaaca 20
<210> 2760
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2760
cgtgttttta tttaacaata 20
<210> 2761
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2761
atttcttata tttatgggct 20
<210> 2762
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2762
tatagtagta tttatagctc 20
<210> 2763
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2763
accccatttc aaagacaagg 20
<210> 2764
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2764
tggaggttaa ttcattacac 20
<210> 2765
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2765
ttggccttat catacctaaa 20
<210> 2766
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2766
gtgcccagcc cttccacctg 20
<210> 2767
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2767
gactttaccc caagcccagc 20
<210> 2768
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2768
tgcccaaaac aattcaaacc 20
<210> 2769
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2769
agttcatttt ctttctccta 20
<210> 2770
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2770
gtctggtttc tgcagaggct 20
<210> 2771
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2771
cctttggaac ctcaattaag 20
<210> 2772
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2772
tgtcaccacc atactatatc 20
<210> 2773
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2773
cccctcagtt ttatatgcca 20
<210> 2774
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2774
gcgccacaga cttatggcct 20
<210> 2775
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2775
ggcagggtaa aaatggctta 20
<210> 2776
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2776
gagcacttta ccaatacatt 20
<210> 2777
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2777
accaactatc tattttttga 20
<210> 2778
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2778
tgtaaccaat ctatcacacc 20
<210> 2779
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2779
acacaaatcc cacattaaaa 20
<210> 2780
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2780
tgggcattct taactttgtc 20
<210> 2781
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2781
ttgtatattt caatcttaga 20
<210> 2782
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2782
ttctgggctc ataattattt 20
<210> 2783
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2783
tagaatagcc tttataactt 20
<210> 2784
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2784
ttcagttatt ttctctccac 20
<210> 2785
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2785
tcctgccaaa aaatcttctt 20
<210> 2786
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2786
actccctaca ctgtagcaac 20
<210> 2787
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2787
aatggtatcc cattcttccg 20
<210> 2788
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2788
ggcctcaaaa tattattgag 20
<210> 2789
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2789
ttaactgatc attaaccgtt 20
<210> 2790
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2790
aagattattc agataatctg 20
<210> 2791
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2791
ggccttagaa ttaaatgctg 20
<210> 2792
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2792
ctcctcgata ctaacccctt 20
<210> 2793
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2793
tctcaaaact ccaaagacac 20
<210> 2794
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2794
gtgagccaca ttatacacac 20
<210> 2795
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2795
tcttgcaaac ctcttagagt 20
<210> 2796
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2796
attgactgaa ataagtagga 20
<210> 2797
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2797
tagttctgat acatttctag 20
<210> 2798
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2798
catattatct ccaaataagc 20
<210> 2799
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2799
ggtctatgag aattgtagaa 20
<210> 2800
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2800
ctgagtccct aaaactggat 20
<210> 2801
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2801
agtcaatttc caatgtcctt 20
<210> 2802
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2802
agtttgcaaa cctccctctc 20
<210> 2803
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2803
tggagccttt catgaagtag 20
<210> 2804
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2804
ctctggaaac ttcagttcgc 20
<210> 2805
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2805
gttaactttc caaatctgcc 20
<210> 2806
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2806
atcttcaaaa tctaattcct 20
<210> 2807
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2807
atactagttc ataattcaca 20
<210> 2808
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2808
aagaaaattc tcagagtttc 20
<210> 2809
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2809
agtcaggtat ttgttcagtt 20
<210> 2810
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2810
gtaaatagtg atattaatga 20
<210> 2811
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2811
gctccccgcc ccagcactca 20
<210> 2812
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2812
ttgttggttt cttattaata 20
<210> 2813
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2813
attgtacaac cctactccag 20
<210> 2814
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2814
gtggttcatg aaacagtagc 20
<210> 2815
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2815
cctatgccag aaacacaaca 20
<210> 2816
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2816
ctatatacaa aaaaacatgt 20
<210> 2817
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2817
cccccattta aatgaggtgt 20
<210> 2818
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2818
cagttgaacc atttgtatgc 20
<210> 2819
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2819
tgcactaact aaaggattta 20
<210> 2820
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2820
aattttcttt tcaataaggt 20
<210> 2821
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2821
ttctacctag aaaacctgca 20
<210> 2822
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2822
ctcgaaaaac atatccccca 20
<210> 2823
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2823
tggtaatttt aaaatatggg 20
<210> 2824
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2824
gtgttaattc aaaaaatttc 20
<210> 2825
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2825
tgcatacaaa tttagtctgt 20
<210> 2826
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2826
tctagattac aaaccatcct 20
<210> 2827
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2827
tttcatttta tttaagccaa 20
<210> 2828
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2828
aagatgtttt aaaatctgac 20
<210> 2829
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2829
gtacttgttc cttaaccaag 20
<210> 2830
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2830
tcagtttacc tttaatggaa 20
<210> 2831
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2831
tgctcaatat tttaaacatt 20
<210> 2832
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2832
gtcggataaa tttatccaca 20
<210> 2833
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2833
ttagcaaaca tttatgagca 20
<210> 2834
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2834
cttccaatcc attacatctt 20
<210> 2835
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2835
ccttccaacc cttagccttt 20
<210> 2836
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2836
agccaaaaac ccatggacca 20
<210> 2837
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2837
acagtaatct tttatacaag 20
<210> 2838
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2838
ttcccgaacc cttaaggata 20
<210> 2839
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2839
agttgacacc tttatagtag 20
<210> 2840
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2840
gtcttaaaac tattcactgt 20
<210> 2841
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2841
ataactagcc ccactctcca 20
<210> 2842
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2842
gttggcctta tcatacctaa 20
<210> 2843
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2843
gctgccttcc atctgttttt 20
<210> 2844
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2844
tgactttacc ccaagcccag 20
<210> 2845
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2845
gagacaagaa acactgtctc 20
<210> 2846
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2846
ctcaaggtag ttcattttct 20
<210> 2847
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2847
gcctacaatc ccagctttag 20
<210> 2848
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2848
gagaaaaccc ctcaggaagg 20
<210> 2849
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2849
tctgtcacca ccatactata 20
<210> 2850
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2850
ctaaacaccc ctcagtttta 20
<210> 2851
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2851
tggatgcgcc acagacttat 20
<210> 2852
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2852
aggcagggta aaaatggctt 20
<210> 2853
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2853
ccagagcact ttaccaatac 20
<210> 2854
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2854
caccaactat ctattttttg 20
<210> 2855
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2855
cagttgtaac caatctatca 20
<210> 2856
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2856
ctcctaacac aaatcccaca 20
<210> 2857
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2857
cgaaattatt aaattgggca 20
<210> 2858
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2858
gattgtatat ttcaatctta 20
<210> 2859
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2859
acaacaccga ctcacttctg 20
<210> 2860
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2860
tcaaacaccc taagcagtaa 20
<210> 2861
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2861
cttcagttat tttctctcca 20
<210> 2862
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2862
atcctgccaa aaaatcttct 20
<210> 2863
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2863
ccttactccc tacactgtag 20
<210> 2864
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2864
atgttcttcc ccatctccat 20
<210> 2865
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2865
cggcctcaaa atattattga 20
<210> 2866
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2866
gatataaaca ttcttaaagg 20
<210> 2867
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2867
ggaagattat tcagataatc 20
<210> 2868
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2868
aggccttaga attaaatgct 20
<210> 2869
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2869
cagtctcctc gatactaacc 20
<210> 2870
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2870
atctcaaaac tccaaagaca 20
<210> 2871
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2871
tgtgagccac attatacaca 20
<210> 2872
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2872
ctcttgcaaa cctcttagag 20
<210> 2873
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2873
tcctgctacc ccccaacagt 20
<210> 2874
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2874
ttcatcttct ttgtttcctt 20
<210> 2875
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2875
aacaaaatac atattatctc 20
<210> 2876
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2876
ccgtttctac agaaatttaa 20
<210> 2877
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2877
tctgagtccc taaaactgga 20
<210> 2878
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2878
cccagcccct aaaaggatgc 20
<210> 2879
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2879
aggtatgaac tcacacagac 20
<210> 2880
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2880
ttccaccttc tttagctccc 20
<210> 2881
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2881
caggcaatcc cattttctct 20
<210> 2882
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2882
atgttctttt aaatggttaa 20
<210> 2883
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2883
catcttcaaa atctaattcc 20
<210> 2884
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2884
cacatactag ttcataattc 20
<210> 2885
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2885
tctctcaatg aatctgaaga 20
<210> 2886
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2886
gggtaaaaga aaagtcaggt 20
<210> 2887
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2887
ttgtaaatag tgatattaat 20
<210> 2888
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2888
ctgcggttcc tcccccgggt 20
<210> 2889
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2889
atatatttag aaatccctag 20
<210> 2890
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2890
aattgtacaa ccctactcca 20
<210> 2891
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2891
gcaacagacc agtctgttga 20
<210> 2892
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2892
tccctatgcc agaaacacaa 20
<210> 2893
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2893
tctatataca aaaaaacatg 20
<210> 2894
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2894
ccccccattt aaatgaggtg 20
<210> 2895
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2895
tacagttgaa ccatttgtat 20
<210> 2896
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2896
gcacaggtat caagttcaaa 20
<210> 2897
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2897
acttaaaatt ttcttttcaa 20
<210> 2898
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2898
aatgaaataa tttctaccta 20
<210> 2899
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2899
ggcacatttt aaaaagaagc 20
<210> 2900
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2900
tgtttgctat tttaagagcc 20
<210> 2901
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2901
gctagtaaaa tttagggcag 20
<210> 2902
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2902
tctgaaaaac ctcttcctct 20
<210> 2903
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2903
gatgcatttc attactgctt 20
<210> 2904
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2904
atgtaatatt aaatagcatc 20
<210> 2905
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2905
aggtaatttc aaagcttcca 20
<210> 2906
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2906
ctttcaattc cttaaaagga 20
<210> 2907
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2907
acacacaaag aatgaaccat 20
<210> 2908
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2908
atcctaattc aaaaactagt 20
<210> 2909
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2909
agccataaaa ccatgcggtt 20
<210> 2910
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2910
ttacccaaat tatcactgta 20
<210> 2911
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2911
ggacttaacc cttactccaa 20
<210> 2912
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2912
tgttagctat tttatatgga 20
<210> 2913
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2913
ttacacagcc aaaaacccat 20
<210> 2914
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2914
tgagtaattt aaaatgccca 20
<210> 2915
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2915
aaggtctgcc tttaacattt 20
<210> 2916
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2916
gtaaaatttc tttatgtgtg 20
<210> 2917
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2917
agtcttaaaa ctattcactg 20
<210> 2918
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2918
tcaaggactc cataactagc 20
<210> 2919
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2919
gctgatctat ctgttggcct 20
<210> 2920
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2920
tagggctgcc ttccatctgt 20
<210> 2921
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2921
gctgacttta ccccaagccc 20
<210> 2922
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2922
aatgctcaaa aaagccagac 20
<210> 2923
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2923
ctgtgaagag tcaactttgc 20
<210> 2924
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2924
cgcctacaat cccagcttta 20
<210> 2925
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2925
ggaagattct tcaggctagg 20
<210> 2926
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2926
gtctgtcacc accatactat 20
<210> 2927
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2927
cccaaactaa acacccctca 20
<210> 2928
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2928
agccccatcc ttcttttgag 20
<210> 2929
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2929
cgaggattac aggcagggta 20
<210> 2930
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2930
cgtgtcaacc cagagcactt 20
<210> 2931
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2931
agtcaccaac tatctatttt 20
<210> 2932
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2932
tcagttgtaa ccaatctatc 20
<210> 2933
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2933
gcctcctaac acaaatccca 20
<210> 2934
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2934
gcgaaattat taaattgggc 20
<210> 2935
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2935
tgattgtata tttcaatctt 20
<210> 2936
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2936
ggagacaaca ccgactcact 20
<210> 2937
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2937
tttcaaacac cctaagcagt 20
<210> 2938
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2938
gaatcacact tcagttattt 20
<210> 2939
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2939
ccatcctgcc aaaaaatctt 20
<210> 2940
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2940
ccccttactc cctacactgt 20
<210> 2941
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2941
cccatgttct tccccatctc 20
<210> 2942
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2942
ccggcctcaa aatattattg 20
<210> 2943
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2943
aaggatataa acattcttaa 20
<210> 2944
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2944
agcggaagat tattcagata 20
<210> 2945
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2945
ccaaatctcc aaagacaggc 20
<210> 2946
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2946
actggtgccc aaatgtctat 20
<210> 2947
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2947
gcatctcaaa actccaaaga 20
<210> 2948
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2948
tgtgtgagcc acattataca 20
<210> 2949
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2949
ctccatagat cctcttgcaa 20
<210> 2950
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2950
aagagatgaa ctaagcattc 20
<210> 2951
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2951
gttgcttttc tacttcatct 20
<210> 2952
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2952
tctagaacaa aatacatatt 20
<210> 2953
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2953
atccatgaag ccaggcatgg 20
<210> 2954
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2954
catctgagtc cctaaaactg 20
<210> 2955
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2955
gtccccagcc cctaaaagga 20
<210> 2956
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2956
caggtatgaa ctcacacaga 20
<210> 2957
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2957
cttctgtttt taagtcttcc 20
<210> 2958
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2958
gcaggcaatc ccattttctc 20
<210> 2959
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2959
ggagagaaaa atgttctttt 20
<210> 2960
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2960
gctcatcttc aaaatctaat 20
<210> 2961
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2961
atttattgtc acatactagt 20
<210> 2962
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2962
cacatatata aatgtcttta 20
<210> 2963
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2963
gaaagtacta ttttcaatgg 20
<210> 2964
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2964
atgagttgta aatagtgata 20
<210> 2965
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2965
actgcggttc ctcccccggg 20
<210> 2966
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2966
agtcatttta tatatttaga 20
<210> 2967
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2967
gaaatccaaa cattccttga 20
<210> 2968
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2968
gccctgtttt cacctggtgc 20
<210> 2969
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2969
tttccctatg ccagaaacac 20
<210> 2970
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2970
ttctatatac aaaaaaacat 20
<210> 2971
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2971
tccccccatt taaatgaggt 20
<210> 2972
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2972
cacttaattt taatacagtt 20
<210> 2973
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2973
gcagtattca cagaactgaa 20
<210> 2974
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2974
gcacttaaaa ttttcttttc 20
<210> 2975
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2975
tgttttatta taataatgaa 20
<210> 2976
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2976
acatcaaaac gatttctact 20
<210> 2977
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2977
aaccaaaacc aaaagcctct 20
<210> 2978
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2978
aatctaaaat acatctgcat 20
<210> 2979
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2979
cagtttattt aaagatataa 20
<210> 2980
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2980
atcagtaaag aattgatgtc 20
<210> 2981
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2981
cttcataaaa ttccattctg 20
<210> 2982
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2982
gctttcataa tataacaacc 20
<210> 2983
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2983
atcaacaaaa ttatgtatgg 20
<210> 2984
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2984
ggaaacaacc aaagtttttt 20
<210> 2985
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2985
ctgtagtttt aaaagtgcct 20
<210> 2986
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2986
accatatttc tttagaaggt 20
<210> 2987
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2987
gtgaccaaaa tacatatact 20
<210> 2988
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2988
actggattta tttaagtctt 20
<210> 2989
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2989
gagtcttgcc cttaagaagc 20
<210> 2990
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2990
ttgatatttc aaaagagcta 20
<210> 2991
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2991
atgtaaatat tttagcacag 20
<210> 2992
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2992
gactaatttt aaaatatgct 20
<210> 2993
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2993
gagataaaaa ttatgtagtt 20
<210> 2994
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2994
tgggataata tttataagtg 20
<210> 2995
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2995
atcttaatca cagaattcaa 20
<210> 2996
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2996
tgtctgctga tctatctgtt 20
<210> 2997
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2997
ttagggctgc cttccatctg 20
<210> 2998
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2998
cagctgactt taccccaagc 20
<210> 2999
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2999
gcatttaaga aatgctcaaa 20
<210> 3000
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3000
gtttattttc catgtgtcac 20
<210> 3001
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3001
ctccccaaga acagaagagg 20
<210> 3002
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3002
aggaagattc ttcaggctag 20
<210> 3003
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3003
agacccaaat ccgcacccct 20
<210> 3004
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3004
tccccaaact aaacacccct 20
<210> 3005
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3005
tacttcctac ccaaggagga 20
<210> 3006
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3006
ggattccacc ccgaggatta 20
<210> 3007
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3007
ccctaataac acagagcctg 20
<210> 3008
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3008
gcagtcacca actatctatt 20
<210> 3009
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3009
atcagttgta accaatctat 20
<210> 3010
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3010
tcagtaaacc cacaccctag 20
<210> 3011
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3011
ggcgaaatta ttaaattggg 20
<210> 3012
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3012
tttgattgta tatttcaatc 20
<210> 3013
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3013
gatggacgaa cctagacagg 20
<210> 3014
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3014
atcctgtttc aaacacccta 20
<210> 3015
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3015
ttttattgaa tcacacttca 20
<210> 3016
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3016
tccctcttcc catcctgcca 20
<210> 3017
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3017
gcatgtgccc cttactccct 20
<210> 3018
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3018
tcccatgttc ttccccatct 20
<210> 3019
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3019
agcttcaaaa tattgttatt 20
<210> 3020
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3020
ataaggatat aaacattctt 20
<210> 3021
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3021
ggagcggaag attattcaga 20
<210> 3022
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3022
ctccaaatct ccaaagacag 20
<210> 3023
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3023
ttcttgaacc ctcactggtg 20
<210> 3024
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3024
ccgcatctca aaactccaaa 20
<210> 3025
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3025
ggtgtgtgag ccacattata 20
<210> 3026
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3026
ggctccatag atcctcttgc 20
<210> 3027
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3027
tgacctctac ccttgtgagc 20
<210> 3028
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3028
tgttgctttt ctacttcatc 20
<210> 3029
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3029
ctctagaaca aaatacatat 20
<210> 3030
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3030
tctgttttta aaagatccat 20
<210> 3031
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3031
aacaggcctt tcaaggtctg 20
<210> 3032
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3032
agtgtgttta tcactgagtc 20
<210> 3033
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3033
cttgtttgat tttatgcaca 20
<210> 3034
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3034
atcttctgtt tttaagtctt 20
<210> 3035
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3035
tgcaggcaat cccattttct 20
<210> 3036
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3036
ttggagagaa aaatgttctt 20
<210> 3037
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3037
atgctcatct tcaaaatcta 20
<210> 3038
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3038
tggtcattta ttgtcacata 20
<210> 3039
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3039
tgctcacata tataaatgtc 20
<210> 3040
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3040
gttgatacca gatttttttt 20
<210> 3041
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3041
agtcaattca atactcgaag 20
<210> 3042
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3042
tccacattca ctattccgtg 20
<210> 3043
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3043
acagtcattt tatatattta 20
<210> 3044
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3044
caggaaatcc aaacattcct 20
<210> 3045
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3045
tcacatcacc accgaagaaa 20
<210> 3046
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3046
ttggagtttc cctatgccag 20
<210> 3047
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3047
gacaaatttc tatatacaaa 20
<210> 3048
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3048
actcccccca tttaaatgag 20
<210> 3049
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3049
gcacttaatt ttaatacagt 20
<210> 3050
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3050
ggcagtattc acagaactga 20
<210> 3051
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3051
cttaactatt atgtatgcac 20
<210> 3052
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3052
ttgttttatt ataataatga 20
<210> 3053
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3053
gcaggtaaaa ccaaatgaca 20
<210> 3054
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3054
gcaaccaaaa ccaaaagcct 20
<210> 3055
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3055
gggctattaa tttattaaat 20
<210> 3056
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3056
aagatctttt aaagtcctac 20
<210> 3057
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3057
gtaagctcca tttatagaat 20
<210> 3058
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3058
cctcacacac cttaaccctg 20
<210> 3059
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3059
gagataaaaa ttattttggc 20
<210> 3060
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3060
gctaaatttc attagaaaca 20
<210> 3061
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3061
ttttctacaa tttataggcg 20
<210> 3062
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3062
ctgcaccaaa tttatttttg 20
<210> 3063
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3063
actgaaaaaa ctgtatgatc 20
<210> 3064
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3064
ccttttaaaa tttccagaaa 20
<210> 3065
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3065
gaagttagcc aggcatcagg 20
<210> 3066
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3066
gcagagtttt aaaatgcact 20
<210> 3067
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3067
aggcatagta tttagcagaa 20
<210> 3068
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3068
tacttctttc cttaagcaca 20
<210> 3069
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3069
tagtttaaaa tatgtgactc 20
<210> 3070
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3070
ccagaaaaac cttaaactac 20
<210> 3071
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3071
accttcaaac tatcaattct 20
<210> 3072
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3072
ttcctcatct taatcacaga 20
<210> 3073
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3073
gagagtataa aaattatctc 20
<210> 3074
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3074
gtccatcaca cttagggctg 20
<210> 3075
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3075
ctacagctga ctttacccca 20
<210> 3076
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3076
ttgggcattt aagaaatgct 20
<210> 3077
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3077
atgtttattt tccatgtgtc 20
<210> 3078
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3078
cttcctcccc aagaacagaa 20
<210> 3079
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3079
cagtgcctaa ccagttgaga 20
<210> 3080
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3080
ccagagaccc aaatccgcac 20
<210> 3081
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3081
catccccaaa ctaaacaccc 20
<210> 3082
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3082
ctaacctact tcctacccaa 20
<210> 3083
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3083
agccttagaa acaggaacgg 20
<210> 3084
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3084
gccctaataa cacagagcct 20
<210> 3085
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3085
cggcacaaat ccagggctgg 20
<210> 3086
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3086
tagttaaaaa taaggtatcg 20
<210> 3087
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3087
ttcagtaaac ccacacccta 20
<210> 3088
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3088
tggcgaaatt attaaattgg 20
<210> 3089
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3089
cacgcatatt tatgctgttt 20
<210> 3090
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3090
ggatggacga acctagacag 20
<210> 3091
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3091
atatcctgtt tcaaacaccc 20
<210> 3092
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3092
gattttattg aatcacactt 20
<210> 3093
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3093
caaccattcc agactgagct 20
<210> 3094
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3094
acatgcaagc ctgatgtggt 20
<210> 3095
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3095
ctaaaacaca ccagacctcc 20
<210> 3096
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3096
tagcttcaaa atattgttat 20
<210> 3097
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3097
taggtttgtc ataaggatat 20
<210> 3098
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3098
gccacgacca gatatcagct 20
<210> 3099
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3099
actccaaatc tccaaagaca 20
<210> 3100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3100
cttcttgaac cctcactggt 20
<210> 3101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3101
tccgcatctc aaaactccaa 20
<210> 3102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3102
ggacacctac ccatggagag 20
<210> 3103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3103
actgtattct aagtaggagg 20
<210> 3104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3104
cctcctgacc tctacccttg 20
<210> 3105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3105
gatttccaca gattgttgct 20
<210> 3106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3106
cctctagaac aaaatacata 20
<210> 3107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3107
atctgttttt aaaagatcca 20
<210> 3108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3108
aaccacaagc caacaggcct 20
<210> 3109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3109
tgtgagttcc aagaagcagg 20
<210> 3110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3110
cattttattc ttgtttgatt 20
<210> 3111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3111
ctgttgctct ggctgctgct 20
<210> 3112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3112
ttgcggctgc tgttgctctg 20
<210> 3113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3113
caatgtcttg cggctgctgt 20
<210> 3114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3114
cctggtgact tgatgcacga 20
<210> 3115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3115
atcagttcct tgcagcagat 20
<210> 3116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3116
ccataagcta tcagttcctt 20
<210> 3117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3117
tggagaacca taagctatca 20
<210> 3118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3118
catgtgcttt catcacaatg 20
<210> 3119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3119
ctgtaccatg tgctttcatc 20
<210> 3120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3120
taaatactgt gttattttag 20
<210> 3121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3121
ggtatttgtt cagtttagtt 20
<210> 3122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3122
aagtcaggta tttgttcagt 20
<210> 3123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3123
gtttagtgga tccagtcaat 20
<210> 3124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3124
agtgttggtt tagtggatcc 20
<210> 3125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3125
tcccatctta gtgttggttt 20
<210> 3126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3126
ttagagattg ttgttattgt 20
<210> 3127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3127
aaattcttag agattgttgt 20
<210> 3128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3128
tgatctgata ttaaaacatc 20
<210> 3129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3129
tgggtaatga tctgatatta 20
<210> 3130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3130
ggcatatggt gggtaatgat 20
<210> 3131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3131
agtagttttt gtgaggtaaa 20
<210> 3132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3132
gcttgtagta gtttttgtga 20
<210> 3133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3133
ttttctattt gcactagctg 20
<210> 3134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3134
atgtcacctt ttctatttgc 20
<210> 3135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3135
aaacactaga aatccaggga 20
<210> 3136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3136
tgctatgctc acagagaacc 20
<210> 3137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3137
tacagttagt ttgatatgct 20
<210> 3138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3138
ggaataaatt atttactgcg 20
<210> 3139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3139
tactatgtat ttgccacagt 20
<210> 3140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3140
atatttaatc atgttcccga 20
<210> 3141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3141
atagttatat ttaatcatgt 20
<210> 3142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3142
atatgtatac aattctgaca 20
<210> 3143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3143
caatgttctc aggtttatat 20
<210> 3144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3144
cctttcttct ttgttcatag 20
<210> 3145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3145
cttgttcctt tcttctttgt 20
<210> 3146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3146
atttatcctc aggatgcaaa 20
<210> 3147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3147
tttgtttaga tttatcctca 20
<210> 3148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3148
atactccatt tttccttcta 20
<210> 3149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3149
atgtgtaata ctccattttt 20
<210> 3150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3150
ttattacaaa tgtgtaatac 20
<210> 3151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3151
tatgttagtc atttctctct 20
<210> 3152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3152
caagtctatg ttagtcattt 20
<210> 3153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3153
taaggtattt tcatggagtt 20
<210> 3154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3154
ttgtaacagt tatgtttaag 20
<210> 3155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3155
tttactcatt ctaccttcaa 20
<210> 3156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3156
ttggttattt actcattcta 20
<210> 3157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3157
tccataaact tggttattta 20
<210> 3158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3158
ttagcttttc aaatactaaa 20
<210> 3159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3159
tcagcatact tagcttttca 20
<210> 3160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3160
gacagtgtca gcatacttag 20
<210> 3161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3161
tacccaggtt attacactgt 20
<210> 3162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3162
ttgggttttt ctgtacaaag 20
<210> 3163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3163
ttttgtttgg gtttttctgt 20
<210> 3164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3164
ctagttctta tcactattca 20
<210> 3165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3165
atgtcaacta gttcttatca 20
<210> 3166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3166
gactaaacaa tgtcaactag 20
<210> 3167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3167
tgggttttta gttttccttc 20
<210> 3168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3168
aggtcctggg tttttagttt 20
<210> 3169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3169
taaatgactg tggtgcagcc 20
<210> 3170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3170
aagccagtgt ttgcattaaa 20
<210> 3171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3171
aagggccact aaatctgacc 20
<210> 3172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3172
atttcttttt tttttaagtt 20
<210> 3173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3173
gtgtttgata tttctttttt 20
<210> 3174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3174
ctttcaaatg tgtttgatat 20
<210> 3175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3175
ttataacaat ttgcatagtc 20
<210> 3176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3176
gggagtatta taacaatttg 20
<210> 3177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3177
tattttccag ggagtattat 20
<210> 3178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3178
cattatctag tttctggaaa 20
<210> 3179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3179
aatggtcatt atctagtttc 20
<210> 3180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3180
ctaaatctga cttacaaagg 20
<210> 3181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3181
taaaaccaat acattaacat 20
<210> 3182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3182
cattatgctt taagatcaca 20
<210> 3183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3183
aacaatgtct tgcggctgct 20
<210> 3184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3184
tgacttgatg cacgatgctc 20
<210> 3185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3185
ccctggtgac ttgatgcacg 20
<210> 3186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3186
ctatcagttc cttgcagcag 20
<210> 3187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3187
aatggagaac cataagctat 20
<210> 3188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3188
ccatgtgctt tcatcacaat 20
<210> 3189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3189
actgtaccat gtgctttcat 20
<210> 3190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3190
ttcagtttag ttgcagccat 20
<210> 3191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3191
aggtatttgt tcagtttagt 20
<210> 3192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3192
aaaagtcagg tatttgttca 20
<210> 3193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3193
tggtttagtg gatccagtca 20
<210> 3194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3194
tagtgttggt ttagtggatc 20
<210> 3195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3195
tgttgttatt gtatagatac 20
<210> 3196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3196
cttagagatt gttgttattg 20
<210> 3197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3197
ggaaattctt agagattgtt 20
<210> 3198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3198
aatgatctga tattaaaaca 20
<210> 3199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3199
gtgggtaatg atctgatatt 20
<210> 3200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3200
ttgtgaggta aaactgtaaa 20
<210> 3201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3201
tagtagtttt tgtgaggtaa 20
<210> 3202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3202
ccttttctat ttgcactagc 20
<210> 3203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3203
aatgtcacct tttctatttg 20
<210> 3204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3204
aactctctta agtacttata 20
<210> 3205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3205
tatgctatgc tcacagagaa 20
<210> 3206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3206
agtttgatat gctatgctca 20
<210> 3207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3207
cttacagtta gtttgatatg 20
<210> 3208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3208
agcttccaga taaaacctcc 20
<210> 3209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3209
ttcaaaattc tcagcattgg 20
<210> 3210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3210
tatatttaat catgttcccg 20
<210> 3211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3211
ttatatgtat acaattctga 20
<210> 3212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3212
ctcaggttta tatgtataca 20
<210> 3213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3213
ggcaatgttc tcaggtttat 20
<210> 3214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3214
tcctttcttc tttgttcata 20
<210> 3215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3215
tcttgttcct ttcttctttg 20
<210> 3216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3216
agatttatcc tcaggatgca 20
<210> 3217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3217
taatactcca tttttccttc 20
<210> 3218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3218
aatgtgtaat actccatttt 20
<210> 3219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3219
tcatttctct ctggctgtgc 20
<210> 3220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3220
ctatgttagt catttctctc 20
<210> 3221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3221
atcaagtcta tgttagtcat 20
<210> 3222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3222
tttaaggtat tttcatggag 20
<210> 3223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3223
agttatgttt aaggtatttt 20
<210> 3224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3224
acttgtaaca gttatgttta 20
<210> 3225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3225
tatttactca ttctaccttc 20
<210> 3226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3226
cttggttatt tactcattct 20
<210> 3227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3227
ggctgattct agtactgtga 20
<210> 3228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3228
acttagcttt tcaaatacta 20
<210> 3229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3229
aggacagtgt cagcatactt 20
<210> 3230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3230
ttctgtacaa agttcagttg 20
<210> 3231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3231
tttgggtttt tctgtacaaa 20
<210> 3232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3232
agttttgttt gggtttttct 20
<210> 3233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3233
aactagttct tatcactatt 20
<210> 3234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3234
aatgtcaact agttcttatc 20
<210> 3235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3235
tataaaattc acctaaaatt 20
<210> 3236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3236
ctgggttttt agttttcctt 20
<210> 3237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3237
taggtcctgg gtttttagtt 20
<210> 3238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3238
attaaatgac tgtggtgcag 20
<210> 3239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3239
tgtttgcatt aaatgactgt 20
<210> 3240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3240
aaaagccagt gtttgcatta 20
<210> 3241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3241
taagggccac taaatctgac 20
<210> 3242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3242
atatttcttt tttttttaag 20
<210> 3243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3243
tgtgtttgat atttcttttt 20
<210> 3244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3244
atgcaaggtc cagggaatac 20
<210> 3245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3245
tattataaca atttgcatag 20
<210> 3246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3246
agggagtatt ataacaattt 20
<210> 3247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3247
tatgagtaat tagcacaaag 20
<210> 3248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3248
tcattatcta gtttctggaa 20
<210> 3249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3249
aaatggtcat tatctagttt 20
<210> 3250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3250
acttccaatt ttgaaatact 20
<210> 3251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3251
gaaagcccca gcacataaat 20
<210> 3252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3252
tgaaagctgg ccgatatccc 20
<210> 3253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3253
tcttgcggct gctgttgctc 20
<210> 3254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3254
gaaacaatgt cttgcggctg 20
<210> 3255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3255
gtgacttgat gcacgatgct 20
<210> 3256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3256
accctggtga cttgatgcac 20
<210> 3257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3257
agctatcagt tccttgcagc 20
<210> 3258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3258
aaccataagc tatcagttcc 20
<210> 3259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3259
acaatggaga accataagct 20
<210> 3260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3260
accatgtgct ttcatcacaa 20
<210> 3261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3261
aactgtacca tgtgctttca 20
<210> 3262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3262
agaaaagtca ggtatttgtt 20
<210> 3263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3263
ttggtttagt ggatccagtc 20
<210> 3264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3264
ttagtgttgg tttagtggat 20
<210> 3265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3265
attgttgtta ttgtatagat 20
<210> 3266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3266
atggaaattc ttagagattg 20
<210> 3267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3267
taatgatctg atattaaaac 20
<210> 3268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3268
ggtgggtaat gatctgatat 20
<210> 3269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3269
ttttgtgagg taaaactgta 20
<210> 3270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3270
accttttcta tttgcactag 20
<210> 3271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3271
aaatgtcacc ttttctattt 20
<210> 3272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3272
gctatttttt ccagaaagtc 20
<210> 3273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3273
gatatgctat gctcacagag 20
<210> 3274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3274
tagtttgata tgctatgctc 20
<210> 3275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3275
aatttttttt aacatcttgc 20
<210> 3276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3276
atcatgttcc cgatattgga 20
<210> 3277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3277
ttatatttaa tcatgttccc 20
<210> 3278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3278
aacatagtta tatttaatca 20
<210> 3279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3279
gtttatatgt atacaattct 20
<210> 3280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3280
tctcaggttt atatgtatac 20
<210> 3281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3281
tcacagggaa taatgaagag 20
<210> 3282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3282
ttcctttctt ctttgttcat 20
<210> 3283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3283
ctcttgttcc tttcttcttt 20
<210> 3284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3284
ttagatttat cctcaggatg 20
<210> 3285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3285
ggtttgttta gatttatcct 20
<210> 3286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3286
gtaatactcc atttttcctt 20
<210> 3287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3287
aaatgtgtaa tactccattt 20
<210> 3288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3288
agtcatttct ctctggctgt 20
<210> 3289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3289
aaatcaagtc tatgttagtc 20
<210> 3290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3290
tgtttaaggt attttcatgg 20
<210> 3291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3291
cagttatgtt taaggtattt 20
<210> 3292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3292
ctgttcttag cttcccagct 20
<210> 3293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3293
ttatttactc attctacctt 20
<210> 3294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3294
acttggttat ttactcattc 20
<210> 3295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3295
aatctccagt tatgagtaag 20
<210> 3296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3296
atacttagct tttcaaatac 20
<210> 3297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3297
tgtcagcata cttagctttt 20
<210> 3298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3298
ccaggacagt gtcagcatac 20
<210> 3299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3299
ttttctgtac aaagttcagt 20
<210> 3300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3300
ttagttttgt ttgggttttt 20
<210> 3301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3301
caactagttc ttatcactat 20
<210> 3302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3302
caatgtcaac tagttcttat 20
<210> 3303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3303
ttagttttcc ttcttgtctt 20
<210> 3304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3304
cctgggtttt tagttttcct 20
<210> 3305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3305
attaggtcct gggtttttag 20
<210> 3306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3306
gcattaaatg actgtggtgc 20
<210> 3307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3307
gtgtttgcat taaatgactg 20
<210> 3308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3308
actaaatctg accttcctca 20
<210> 3309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3309
tggtaagggc cactaaatct 20
<210> 3310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3310
tgatatttct ttttttttta 20
<210> 3311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3311
atgtgtttga tatttctttt 20
<210> 3312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3312
tgatctaaat tgtgtctttt 20
<210> 3313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3313
gtattataac aatttgcata 20
<210> 3314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3314
cagggagtat tataacaatt 20
<210> 3315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3315
tcatagaagc attctgtgtt 20
<210> 3316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3316
gtcattatct agtttctgga 20
<210> 3317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3317
caaatggtca ttatctagtt 20
<210> 3318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3318
atctgctagg catgcgggat 20
<210> 3319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3319
tgatttgtac acacccagca 20
<210> 3320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3320
gcactgatcc aataaaaccc 20
<210> 3321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3321
cggctgctgt tgctctggct 20
<210> 3322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3322
gtcttgcggc tgctgttgct 20
<210> 3323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3323
ggtgacttga tgcacgatgc 20
<210> 3324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3324
ccaccctggt gacttgatgc 20
<210> 3325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3325
taagctatca gttccttgca 20
<210> 3326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3326
gaaccataag ctatcagttc 20
<210> 3327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3327
ctttcatcac aatggagaac 20
<210> 3328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3328
taccatgtgc tttcatcaca 20
<210> 3329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3329
aaaactgtac catgtgcttt 20
<210> 3330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3330
tttgttcagt ttagttgcag 20
<210> 3331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3331
tcaggtattt gttcagttta 20
<210> 3332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3332
aaagaaaagt caggtatttg 20
<210> 3333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3333
gttggtttag tggatccagt 20
<210> 3334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3334
cttagtgttg gtttagtgga 20
<210> 3335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3335
agattgttgt tattgtatag 20
<210> 3336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3336
ttcttagaga ttgttgttat 20
<210> 3337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3337
ttatggaaat tcttagagat 20
<210> 3338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3338
gtaatgatct gatattaaaa 20
<210> 3339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3339
tggtgggtaa tgatctgata 20
<210> 3340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3340
gtttttgtga ggtaaaactg 20
<210> 3341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3341
tgtagtagtt tttgtgaggt 20
<210> 3342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3342
cttggtgctt gtagtagttt 20
<210> 3343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3343
caccttttct atttgcacta 20
<210> 3344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3344
tcaaatgtca ccttttctat 20
<210> 3345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3345
atagcaagtc ccctgaagct 20
<210> 3346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3346
tgatatgcta tgctcacaga 20
<210> 3347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3347
ttagtttgat atgctatgct 20
<210> 3348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3348
cacagaacac tttttccaga 20
<210> 3349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3349
atcacacagc agcatgttta 20
<210> 3350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3350
taatcatgtt cccgatattg 20
<210> 3351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3351
ctaacatagt tatatttaat 20
<210> 3352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3352
ggtttatatg tatacaattc 20
<210> 3353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3353
ttctcaggtt tatatgtata 20
<210> 3354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3354
ttctttgttc ataggagaac 20
<210> 3355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3355
gttcctttct tctttgttca 20
<210> 3356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3356
acctcttgtt cctttcttct 20
<210> 3357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3357
gtttagattt atcctcagga 20
<210> 3358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3358
gggtttgttt agatttatcc 20
<210> 3359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3359
tgtaatactc catttttcct 20
<210> 3360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3360
caaatgtgta atactccatt 20
<210> 3361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3361
ttagtcattt ctctctggct 20
<210> 3362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3362
gtctatgtta gtcatttctc 20
<210> 3363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3363
aaaaatcaag tctatgttag 20
<210> 3364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3364
atgtttaagg tattttcatg 20
<210> 3365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3365
acagttatgt ttaaggtatt 20
<210> 3366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3366
aaaacagact tcgatttgga 20
<210> 3367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3367
gttatttact cattctacct 20
<210> 3368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3368
aacttggtta tttactcatt 20
<210> 3369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3369
aagttggaga agtcaccagc 20
<210> 3370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3370
gcatacttag cttttcaaat 20
<210> 3371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3371
gtgtcagcat acttagcttt 20
<210> 3372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3372
tcttggaggt gacatttgtg 20
<210> 3373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3373
gtttttctgt acaaagttca 20
<210> 3374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3374
tgtttgggtt tttctgtaca 20
<210> 3375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3375
ctttagtttt gtttgggttt 20
<210> 3376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3376
tcaactagtt cttatcacta 20
<210> 3377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3377
acaatgtcaa ctagttctta 20
<210> 3378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3378
ttttagtttt ccttcttgtc 20
<210> 3379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3379
agattaggtc ctgggttttt 20
<210> 3380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3380
tgcattaaat gactgtggtg 20
<210> 3381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3381
agtgtttgca ttaaatgact 20
<210> 3382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3382
ccactaaatc tgaccttcct 20
<210> 3383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3383
tccattggta agggccacta 20
<210> 3384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3384
tttgatattt cttttttttt 20
<210> 3385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3385
aatgtgtttg atatttcttt 20
<210> 3386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3386
cagttttgag atggtttgaa 20
<210> 3387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3387
agtattataa caatttgcat 20
<210> 3388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3388
ccagggagta ttataacaat 20
<210> 3389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3389
ctagtttctg gaaagtaatg 20
<210> 3390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3390
ggtcattatc tagtttctgg 20
<210> 3391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3391
aacaaatggt cattatctag 20
<210> 3392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3392
ccaaattcct ggttgctgtg 20
<210> 3393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3393
agggcctctt ggattttgtt 20
<210> 3394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3394
gcggctgctg ttgctctggc 20
<210> 3395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3395
tgtcttgcgg ctgctgttgc 20
<210> 3396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3396
gaccaccctg gtgacttgat 20
<210> 3397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3397
ataagctatc agttccttgc 20
<210> 3398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3398
agaaccataa gctatcagtt 20
<210> 3399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3399
tgctttcatc acaatggaga 20
<210> 3400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3400
ggaaaactgt accatgtgct 20
<210> 3401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3401
tatttgttca gtttagttgc 20
<210> 3402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3402
gtcaggtatt tgttcagttt 20
<210> 3403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3403
agtggatcca gtcaattcaa 20
<210> 3404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3404
agagattgtt gttattgtat 20
<210> 3405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3405
attcttagag attgttgtta 20
<210> 3406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3406
ctgatattaa aacatccagt 20
<210> 3407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3407
ggtaatgatc tgatattaaa 20
<210> 3408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3408
tatggtgggt aatgatctga 20
<210> 3409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3409
tagtttttgt gaggtaaaac 20
<210> 3410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3410
ttgtagtagt ttttgtgagg 20
<210> 3411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3411
ctatttgcac tagctgccta 20
<210> 3412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3412
tcaccttttc tatttgcact 20
<210> 3413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3413
tctcaaatgt caccttttct 20
<210> 3414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3414
aaccatatga catctcaaca 20
<210> 3415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3415
ttgatatgct atgctcacag 20
<210> 3416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3416
gttagtttga tatgctatgc 20
<210> 3417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3417
caactgaaaa ttctacacac 20
<210> 3418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3418
cagtagtctc cccatagcca 20
<210> 3419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3419
tttaatcatg ttcccgatat 20
<210> 3420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3420
agttatattt aatcatgttc 20
<210> 3421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3421
cactaacata gttatattta 20
<210> 3422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3422
aggtttatat gtatacaatt 20
<210> 3423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3423
gttctcaggt ttatatgtat 20
<210> 3424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3424
tcttctttgt tcataggaga 20
<210> 3425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3425
caacctcttg ttcctttctt 20
<210> 3426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3426
tgtttagatt tatcctcagg 20
<210> 3427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3427
tccatttttc cttctagatt 20
<210> 3428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3428
gtgtaatact ccatttttcc 20
<210> 3429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3429
tacaaatgtg taatactcca 20
<210> 3430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3430
tgttagtcat ttctctctgg 20
<210> 3431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3431
agtctatgtt agtcatttct 20
<210> 3432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3432
gatgataaat taaggcagag 20
<210> 3433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3433
tatgtttaag gtattttcat 20
<210> 3434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3434
aacagttatg tttaaggtat 20
<210> 3435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3435
ctcattctac cttcaactct 20
<210> 3436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3436
ggttatttac tcattctacc 20
<210> 3437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3437
taaacttggt tatttactca 20
<210> 3438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3438
gagtgagcat tagatggtca 20
<210> 3439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3439
agcatactta gcttttcaaa 20
<210> 3440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3440
agtgtcagca tacttagctt 20
<210> 3441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3441
agggaaatgg tcattttcta 20
<210> 3442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3442
gggtttttct gtacaaagtt 20
<210> 3443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3443
ttgtttgggt ttttctgtac 20
<210> 3444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3444
ttcttatcac tattcagtca 20
<210> 3445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3445
gtcaactagt tcttatcact 20
<210> 3446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3446
aaacaatgtc aactagttct 20
<210> 3447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3447
gtttttagtt ttccttcttg 20
<210> 3448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3448
gtcctgggtt tttagttttc 20
<210> 3449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3449
gaagattagg tcctgggttt 20
<210> 3450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3450
ttgcattaaa tgactgtggt 20
<210> 3451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3451
cagtgtttgc attaaatgac 20
<210> 3452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3452
ggccactaaa tctgaccttc 20
<210> 3453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3453
aatccattgg taagggccac 20
<210> 3454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3454
gtttgatatt tctttttttt 20
<210> 3455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3455
caaatgtgtt tgatatttct 20
<210> 3456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3456
aacaatttgc atagtctctc 20
<210> 3457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3457
gagtattata acaatttgca 20
<210> 3458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3458
ttccagggag tattataaca 20
<210> 3459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3459
atctagtttc tggaaagtaa 20
<210> 3460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3460
ataacaaatg gtcattatct 20
<210> 3461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3461
aatccaaatc ttgtattctt 20
<210> 3462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3462
tctagaaatg attttgatta 20
<210> 3463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3463
tgggcattta agaaatgctc 20
<210> 3464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3464
tgcggctgct gttgctctgg 20
<210> 3465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3465
atgtcttgcg gctgctgttg 20
<210> 3466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3466
ctggtgactt gatgcacgat 20
<210> 3467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3467
tggaccaccc tggtgacttg 20
<210> 3468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3468
cataagctat cagttccttg 20
<210> 3469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3469
gagaaccata agctatcagt 20
<210> 3470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3470
tgtgctttca tcacaatgga 20
<210> 3471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3471
tgtaccatgt gctttcatca 20
<210> 3472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3472
ttggaaaact gtaccatgtg 20
<210> 3473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3473
ttagtggatc cagtcaattc 20
<210> 3474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3474
ccatcttagt gttggtttag 20
<210> 3475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3475
tagagattgt tgttattgta 20
<210> 3476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3476
aattcttaga gattgttgtt 20
<210> 3477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3477
catatggtgg gtaatgatct 20
<210> 3478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3478
gtagtttttg tgaggtaaaa 20
<210> 3479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3479
ttctatttgc actagctgcc 20
<210> 3480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3480
tgtcaccttt tctatttgca 20
<210> 3481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3481
cctctcaaat gtcacctttt 20
<210> 3482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3482
ctatgctcac agagaacctg 20
<210> 3483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3483
tttgatatgc tatgctcaca 20
<210> 3484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3484
cagttagttt gatatgctat 20
<210> 3485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3485
tgtgatttat cgctgacctt 20
<210> 3486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3486
gaatggttct cttttacggg 20
<210> 3487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3487
tatttaatca tgttcccgat 20
<210> 3488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3488
tagttatatt taatcatgtt 20
<210> 3489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3489
atgtatacaa ttctgacagt 20
<210> 3490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3490
caggtttata tgtatacaat 20
<210> 3491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3491
atgttctcag gtttatatgt 20
<210> 3492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3492
tttcttcttt gttcatagga 20
<210> 3493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3493
ttgttccttt cttctttgtt 20
<210> 3494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3494
aacaacctct tgttcctttc 20
<210> 3495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3495
ttgtttagat ttatcctcag 20
<210> 3496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3496
actccatttt tccttctaga 20
<210> 3497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3497
attacaaatg tgtaatactc 20
<210> 3498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3498
atgttagtca tttctctctg 20
<210> 3499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3499
aagtctatgt tagtcatttc 20
<210> 3500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3500
aggtattttc atggagtttc 20
<210> 3501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3501
ttatgtttaa ggtattttca 20
<210> 3502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3502
gtaacagtta tgtttaaggt 20
<210> 3503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3503
tactcattct accttcaact 20
<210> 3504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3504
cataaacttg gttatttact 20
<210> 3505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3505
ccactaccac ccccaaacca 20
<210> 3506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3506
cagcatactt agcttttcaa 20
<210> 3507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3507
cagtgtcagc atacttagct 20
<210> 3508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3508
catgtattgc taggagccag 20
<210> 3509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3509
tgggtttttc tgtacaaagt 20
<210> 3510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3510
tttgtttggg tttttctgta 20
<210> 3511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3511
agttcttatc actattcagt 20
<210> 3512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3512
ctaaacaatg tcaactagtt 20
<210> 3513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3513
gggtttttag ttttccttct 20
<210> 3514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3514
ggtcctgggt ttttagtttt 20
<210> 3515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3515
aatgactgtg gtgcagcctc 20
<210> 3516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3516
tttgcattaa atgactgtgg 20
<210> 3517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3517
gccagtgttt gcattaaatg 20
<210> 3518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3518
agggccacta aatctgacct 20
<210> 3519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3519
agaatccatt ggtaagggcc 20
<210> 3520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3520
ttcaaatgtg tttgatattt 20
<210> 3521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3521
ataacaattt gcatagtctc 20
<210> 3522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3522
ttttccaggg agtattataa 20
<210> 3523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3523
ttatctagtt tctggaaagt 20
<210> 3524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3524
atggtcatta tctagtttct 20
<210> 3525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3525
tgataacaaa tggtcattat 20
<210> 3526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3526
catcaaaatt gtgcacaatt 20
<210> 3527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3527
tgaaaacatg ttgtgtgatt 20
<210> 3528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3528
ttgttggatt ctttttttct 20
<210> 3529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3529
gacttgatgc acgatgctct 20
<210> 3530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3530
atgcacgatg ctctgtaaag 20
<210> 3531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3531
tgatgcacga tgctctgtaa 20
<210> 3532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3532
cttgatgcac gatgctctgt 20
<210> 3533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3533
tgattgtgtt ccattgtaaa 20
<210> 3534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3534
gagttgtcca tagtcatgaa 20
<210> 3535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3535
cgagttgtcc atagtcatga 20
<210> 3536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3536
tgcacttttg tttctacagc 20
<210> 3537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3537
aggccttgca cttttgtttc 20
<210> 3538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3538
aagtggcacc cgagttgtcc 20
<210> 3539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3539
gccttgcact tttgtttcta 20
<210> 3540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3540
gattgtgttc cattgtaaac 20
<210> 3541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3541
gtggatccag tcaattcaat 20
<210> 3542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3542
aatagcagct atttcatgac 20
<210> 3543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3543
tggatccagt caattcaata 20
<210> 3544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3544
tcaattcaat actcgaagta 20
<210> 3545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3545
ggatccagtc aattcaatac 20
<210> 3546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3546
caatgactct tcactcatgt 20
<210> 3547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3547
actattttca actcaagctg 20
<210> 3548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3548
gactcttcac tcatgtttat 20
<210> 3549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3549
ggtactggct catcagttgt 20
<210> 3550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3550
aatgactctt cactcatgtt 20
<210> 3551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3551
agcaatgact cttcactcat 20
<210> 3552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3552
aagcaatgac tcttcactca 20
<210> 3553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3553
aaccaatcta tcacaccaat 20
<210> 3554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3554
agccatccaa gtaagaatat 20
<210> 3555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3555
accaatctat cacaccaatg 20
<210> 3556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3556
caatctatca caccaatgca 20
<210> 3557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3557
cagccatcca agtaagaata 20
<210> 3558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3558
tattgtcaca tactagttca 20
<210> 3559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3559
ctgactaatt tcttggtgat 20
<210> 3560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3560
gtggtcattt attgtcacat 20
<210> 3561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3561
gtcacatact agttcataat 20
<210> 3562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3562
ttattgtcac atactagttc 20
<210> 3563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3563
cccgagttgt ccatagtcat 20
<210> 3564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3564
cattgtaaac gcaaaaggcc 20
<210> 3565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3565
cagtcaattc aatactcgaa 20
<210> 3566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3566
gtccatagtc atgaactata 20
<210> 3567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3567
atagcagcta tttcatgact 20
<210> 3568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3568
gtcaattcaa tactcgaagt 20
<210> 3569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3569
gatccagtca attcaatact 20
<210> 3570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3570
taaccaatct atcacaccaa 20
<210> 3571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3571
atgactcttc actcatgttt 20
<210> 3572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3572
gactattttc aactcaagct 20
<210> 3573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3573
cttggtggtc atttattgtc 20
<210> 3574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3574
ggtggtcatt tattgtcaca 20
<210> 3575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3575
tagttgcagc catccaagta 20
<210> 3576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3576
tggtggtcat ttattgtcac 20
<210> 3577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3577
gttcagttta gttgcagcca 20
<210> 3578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3578
catactagtt cataattcac 20
<210> 3579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3579
tcgccctgac taatttcttg 20
<210> 3580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3580
ccctgactaa tttcttggtg 20
<210> 3581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3581
gccctgacta atttcttggt 20
<210> 3582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3582
cgtgggtgtt cgctctctcc 20
<210> 3583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3583
gcgtgggtgt tcgctctctc 20
<210> 3584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3584
ctcttaccat caaaggctaa 20
<210> 3585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3585
tgtggcagcc cgtattcctc 20
<210> 3586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3586
gggtgttcgc tctctccctc 20
<210> 3587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3587
gtgggtgttc gctctctccc 20
<210> 3588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3588
ccgtattcct cttaccatca 20
<210> 3589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3589
gtattcctct taccatcaaa 20
<210> 3590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3590
cccgtattcc tcttaccatc 20
<210> 3591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3591
ttttcttttc gccctgacta 20
<210> 3592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3592
tcatttattg tcacatacta 20
<210> 3593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3593
cacccgagtt gtccatagtc 20
<210> 3594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3594
gtcatttatt gtcacatact 20
<210> 3595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3595
ttttttcttt tcgccctgac 20
<210> 3596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3596
gttgtccata gtcatgaact 20
<210> 3597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3597
taattcacat tcatcccttt 20
<210> 3598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3598
tcctaacact gcacagaaac 20
<210> 3599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3599
tccatagtca tgaactataa 20
<210> 3600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3600
ccatagtcat gaactataaa 20
<210> 3601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3601
catagtcatg aactataaac 20
<210> 3602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3602
acagaaacca gcgtgggtgt 20
<210> 3603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3603
ctgcacagaa accagcgtgg 20
<210> 3604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3604
cataattcac attcatccct 20
<210> 3605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3605
gcacccgagt tgtccatagt 20
<210> 3606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3606
tttttctttt cgccctgact 20
<210> 3607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3607
actgcacaga aaccagcgtg 20
<210> 3608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3608
tgtgttccat tgtaaacgca 20
<210> 3609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3609
cctaacactg cacagaaacc 20
<210> 3610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3610
ttttatccca gtcattggcc 20
<210> 3611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3611
ccagtcattg gcccccaaac 20
<210> 3612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3612
ttttctgtgc ctcctgacct 20
<210> 3613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3613
gacctctacc cttgtgagca 20
<210> 3614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3614
cactgcacag aaaccagcgt 20
<210> 3615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3615
ttaatgagaa caaagtctat 20
<210> 3616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3616
catccaagta agaatattta 20
<210> 3617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3617
aacactgcac agaaaccagc 20
<210> 3618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3618
aatgagaaca aagtctatgt 20
<210> 3619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3619
gccatccaag taagaatatt 20
<210> 3620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3620
gttgcagcca tccaagtaag 20
<210> 3621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3621
ccgagttgtc catagtcatg 20
<210> 3622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3622
caaagtctat gtggcagccc 20
<210> 3623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3623
taacactgca cagaaaccag 20
<210> 3624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3624
cagtttagtt gcagccatcc 20
<210> 3625
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3625
cacgctttta ttttctg 17
<210> 3626
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3626
ccacgctttt attttct 17
<210> 3627
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3627
tttataactt ttctttc 17
<210> 3628
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3628
ctttataact tttcttt 17
<210> 3629
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3629
cctttataac ttttctt 17
<210> 3630
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3630
gcctttataa cttttct 17
<210> 3631
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3631
tcatttattg tcacata 17
<210> 3632
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3632
catttattgt cacatac 17
<210> 3633
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3633
gtcatttatt gtcacat 17
<210> 3634
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3634
ggtcatttat tgtcaca 17
<210> 3635
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3635
ccgagttgtc catagtc 17
<210> 3636
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3636
cccgagttgt ccatagt 17
<210> 3637
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3637
acccgagttg tccatag 17
<210> 3638
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3638
tcagtttagt tgcagcc 17
<210> 3639
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3639
cagtttagtt gcagcca 17
<210> 3640
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3640
ttcagtttag ttgcagc 17
<210> 3641
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3641
ttcttttttc tgtgcct 17
<210> 3642
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3642
cgctttuatt ttctgat 17
<210> 3643
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3643
ccacgcuttt attttct 17
<210> 3644
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3644
cctttauaac ttttctt 17
<210> 3645
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3645
catttautgt cacatac 17
<210> 3646
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3646
gtcattuatt gtcacat 17
<210> 3647
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3647
ggtcatutat tgtcaca 17
<210> 3648
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3648
ccgagtugtc catagtc 17
<210> 3649
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3649
cgagttgtcc atagtca 17
<210> 3650
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3650
tttcttuttt ctgtgcc 17
<210> 3651
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3651
ttctttuttc tgtgcct 17
<210> 3652
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3652
cccgagutgt ccatagt 17
<210> 3653
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3653
ttcagtutag ttgcagc 17
<210> 3654
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3654
tcagttuagt tgcagcc 17
<210> 3655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3655
ttgttcagtt tagttgcagc 20
<210> 3656
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonculeotide
<400> 3656
gcacccgagt tgtccat 17
<210> 3657
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3657
cagcccgtat tcctctt 17
<210> 3658
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3658
cacccgagtt gtccata 17
<210> 3659
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3659
gagttgtcca tagtcat 17
<210> 3660
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3660
cccgtattcc tcttacc 17
<210> 3661
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3661
agcccgtatt cctctta 17
<210> 3662
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3662
agtttagttg cagccat 17
<210> 3663
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3663
gtattcctct taccatc 17
<210> 3664
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3664
cgtattcctc ttaccat 17
<210> 3665
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3665
tgttcagttt agttgca 17
<210> 3666
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3666
tattcctctt accatca 17
<210> 3667
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3667
ccgtattcct cttacca 17
<210> 3668
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3668
gcccgtattc ctcttac 17
<210> 3669
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 3669
ttgttcagtt tagttgc 17
Claims (131)
12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물에 있어서, 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 80% 상보성이며, 이때 상기 변형된 올리고뉴클레오티드는 변형된 당 모이어티와 변형된 뉴클레오시드간 링키지로부터 선택된 적어도 하나의 변형을 포함하는, 올리고머 화합물.
청구항 1에 있어서, 상기 ATXN1 핵산은 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6중 임의의 하나의 핵염기 서열을 갖는, 올리고머 화합물.
청구항 1 또는 2에 있어서, 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 다음의 핵염기 내 동일 길이 부분에 대해 적어도 80% 상보성인, 올리고머 화합물:
서열 식별 번호: 1의 핵염기 5472-5552의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5906-6005의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7868-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8514의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446679-446706의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5472-5552의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5906-6005의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7868-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8514의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446679-446706의 동일 길이 부분;
청구항 1-3 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 다음의 핵염기 내 동일 길이 부분에 대해 적어도 80% 상보성인, 올리고머 화합물:
서열 식별 번호: 1의 핵염기 5489-5508의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5491-5507의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5912-5931의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7892-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8500의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446680-446699의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5489-5508의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5491-5507의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 5912-5931의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 7892-7911의 동일 길이 부분;
서열 식별 번호: 1의 핵염기 8481-8500의 동일 길이 부분; 또는
서열 식별 번호: 2의 핵염기 446680-446699의 동일 길이 부분;
청구항 1-4 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성인, 올리고머 화합물.
12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3624 또는 3655중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 17개, 18개, 19개, 또는 20개 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
12 ~ 30개의 연계된 뉴클레오시드로 구성된 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 3625-3654 또는 3656-3669중 임의의 서열의 적어도 12개, 13개, 14개, 15개, 16개, 또는 17개 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
청구항 6 또는 7에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3669중 임의의 서열의 핵염기 서열을 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
청구항 8에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 22-3669중 임의의 서열의 핵염기 서열로 구성된 핵염기 서열을 갖는, 올리고머 화합물.
청구항 6-9 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 다음에서 선택된 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물:
서열 식별 번호: 196, 274, 352, 430, 508, 2578, 2655, 2732, 2809, 2886, 2963, 3121, 3122, 3190, 3191, 3192, 3262, 3330, 3331, 3332, 3401, 3402, 3575, 3577, 3620, 3624, 3638-3640, 3653-3655, 3662, 3665, 3669;
서열 식별 번호: 42, 120, 198, 276, 509, 587, 2502, 2579, 2656, 2733, 2810, 2887, 2964, 3585, 3588-3590, 3615, 3618, 3622, 3657, 3660, 3661, 3663, 3664, 3666-3668;
서열 식별 번호: 48, 126, 2044, 2121;
서열 식별 번호: 128, 206, 284, 1045, 1122, 1199, 및 1276; 또는
서열 식별 번호: 2475, 2552, 2629, 2706, 2783, 3627-3630, 3644.
서열 식별 번호: 196, 274, 352, 430, 508, 2578, 2655, 2732, 2809, 2886, 2963, 3121, 3122, 3190, 3191, 3192, 3262, 3330, 3331, 3332, 3401, 3402, 3575, 3577, 3620, 3624, 3638-3640, 3653-3655, 3662, 3665, 3669;
서열 식별 번호: 42, 120, 198, 276, 509, 587, 2502, 2579, 2656, 2733, 2810, 2887, 2964, 3585, 3588-3590, 3615, 3618, 3622, 3657, 3660, 3661, 3663, 3664, 3666-3668;
서열 식별 번호: 48, 126, 2044, 2121;
서열 식별 번호: 128, 206, 284, 1045, 1122, 1199, 및 1276; 또는
서열 식별 번호: 2475, 2552, 2629, 2706, 2783, 3627-3630, 3644.
청구항 6-9 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 3638의 핵염기 서열 중 임의의 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 17개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
청구항 6-9 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 서열 식별 번호: 126, 1045, 2552, 3190, 또는 3590의 핵염기 서열 중 임의의 서열의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 연접한 핵염기를 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
청구항 10 또는 11에 있어서, 상기 변형된 올리고뉴클레오티드는 17 내지 30개의 연계된 뉴클레오시드로 구성되며, 126, 1045, 2552, 3190, 3590, 또는 3638중 임의의 서열의 핵염기 서열을 포함하는 핵염기 서열을 갖는, 올리고머 화합물.
청구항 13에 있어서, 상기 변형된 올리고뉴클레오티드는 126, 1045, 2552, 3190, 3590, 또는 3638중 임의의 하나의 핵염기 서열로 구성된 핵염기 서열을 갖는, 올리고머 화합물.
청구항 6-14 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 핵염기 서열은 ATXN1 핵산의 동일 길이 부분에 대해 적어도 85%, 적어도 90%, 적어도 95%, 또는 100% 상보성이며, 이때 상기 ATXN1 핵산은 서열 식별 번호: 1, 서열 식별 번호: 2, 서열 식별 번호: 3, 서열 식별 번호: 4, 서열 식별 번호: 5, 또는 서열 식별 번호: 6의 핵염기 서열을 갖는, 올리고머 화합물.
청구항 1-15 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 16에 있어서, 상기 변형된 당 모이어티는 이환 당 모이어티를 포함하는, 올리고머 화합물.
청구항 17에 있어서, 상기 이환 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-에서 선택된 2'-4' 다리를 포함하는, 올리고머 화합물.
청구항 16-18 중 어느 한 항에 있어서, 상기 변형된 뉴클레오시드는 비-이환 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 19에 있어서, 상기 비-이환 변형된 당 모이어티는 2'-MOE 당 모이어티 또는 2'-OMe 변형된 당 모이어티인, 올리고머 화합물.
청구항 16-20 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 당 대체물을 포함하는, 올리고머 화합물.
청구항 21에 있어서, 상기 당 대체물은 모르폴리노 및 PNA로부터 선택되는, 올리고머 화합물.
청구항 1-16 및 19-22 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 이환 당 모이어티를 포함하지 않는, 올리고머 화합물.
청구항 1-23 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 뉴클레오시드간 링키지를 포함하는, 올리고머 화합물.
청구항 24에 있어서, 적어도 하나의 변형된 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지인, 올리고머 화합물.
청구항 24 또는 25에 있어서, 각 뉴클레오시드간 링키지는 변형된 뉴클레오시드간 링키지인, 올리고머 화합물.
청구항 26에 있어서, 각 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지인, 올리고머 화합물.
청구항 24 또는 25에 있어서, 상기 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지인, 올리고머 화합물.
청구항 1-23 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 또는 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택되는, 올리고머 화합물.
청구항 1-29 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드중 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 또는 적어도 17개, 또는 적어도 18개의 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지인, 올리고머 화합물.
청구항 21에 있어서, 상기 변형된 올리고뉴클레오티드는 다음에서 선택된 뉴클레오시드간 링키지 모티프: sooosssssssssssooss, sssosssssssssssosss, sssosssssssssoss, 또는 sooooossssssssssoss를 갖는, 올리고머 화합물:
이때,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고 o = 포스포디에스테르 뉴클레오시드간 링키지.
이때,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고 o = 포스포디에스테르 뉴클레오시드간 링키지.
청구항 1-31 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 변형된 핵염기를 포함하는, 올리고머 화합물.
청구항 32에 있어서, 상기 변형된 핵염기는 5-메틸 시토신인, 올리고머 화합물.
청구항 1-33 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 5-12개의 연접한 2'-데옥시뉴클레오시드로 구성된 데옥시 영역을 포함하는, 올리고머 화합물.
청구항 34에 있어서, 상기 데옥시 영역의 각 뉴클레오시드는 2'-β-D-데옥시뉴클레오시드인, 올리고머 화합물.
청구항 34 또는 35에 있어서, 상기 데옥시 영역은 6개, 7개, 8개, 9개, 10개, 또는 6-10개의 연계된 뉴클레오시드로 구성된, 올리고머 화합물.
청구항 34-36 중 어느 한 항에 있어서, 상기 데옥시 영역에 바로 인접한 각 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 34-36 중 어느 한 항에 있어서, 상기 데옥시 영역은 5'-측면에 1-6개의 연계된 5'-영역 뉴클레오시드로 구성된 5'-영역에 의해, 및 3'-측면에 1-6개의 연계된 3'-영역 뉴클레오시드로 구성된 3'외부 영역에 의해 플랭킹되며,
상기 5'-영역의 3'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함하고;
상기 3'-영역의 5'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
상기 5'-영역의 3'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함하고;
상기 3'-영역의 5'-최근접 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 38에 있어서, 상기 3'-영역의 각 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 38 또는 39에 있어서, 상기 5'-영역의 각 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 화합물.
청구항 34-40 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
1-6개의 연계된 뉴클레오시드로 구성된 5'-영역;
6-10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
1-6개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 변형된 당 모이어티를 포함한다.
1-6개의 연계된 뉴클레오시드로 구성된 5'-영역;
6-10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
1-6개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 변형된 당 모이어티를 포함한다.
청구항 41에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
6개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
6개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
청구항 41에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 중심 영역; 그리고
5개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
10개의 연계된 뉴클레오시드로 구성된 중심 영역; 그리고
5개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
청구항 41에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드, 그리고 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이며, 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
청구항 41에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이고, 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
5개의 연계된 뉴클레오시드로 구성된 5'-영역;
8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3'-영역;
이때 상기 5'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드이고, 상기 3'-영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 데옥시 영역 뉴클레오시드 각각은 2'-β-D-데옥시뉴클레오시드이다.
청구항 1-33 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
3-7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6-8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
3-6개의 연계된 뉴클레오시드로 구성된 3' 영역;
이때 상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 1 ~ 5이다.
3-7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6-8개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
3-6개의 연계된 뉴클레오시드로 구성된 3' 영역;
이때 상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 1 ~ 5이다.
청구항 1-33 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 다음을 갖는, 올리고머 화합물:
7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3' 영역;
이때 상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 5이다.
7개의 연계된 뉴클레오시드로 구성된 5' 영역;
6개의 연계된 뉴클레오시드로 구성된 데옥시 영역; 그리고
4개의 연계된 뉴클레오시드로 구성된 3' 영역;
이때 상기 3' 영역 뉴클레오시드 각각은 2'-MOE 뉴클레오시드 및 cEt 뉴클레오시드로부터 선택되고, 그리고 상기 5' 영역은 다음 식을 갖고:
(Nk)n(Nd)(Nx)
이때 각 Nk는 이환 뉴클레오시드이며, Nx는 2'-OMe 뉴클레오시드이고, 그리고 Nd는 2'-β-D-데옥시뉴클레오시드이고;
그리고 n은 5이다.
청구항 1-47 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 12-30개, 12-22개, 12-20개, 14-18개, 16-18개, 14-20개, 15-17개, 15-25개, 16-20개, 또는 17-20개의 연계된 뉴클레오시드로 구성된, 올리고머 화합물.
청구항 1-46 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 18-22개 또는 18-20개의 연계된 뉴클레오시드로 구성된, 올리고머 화합물.
청구항 1-47 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 17개의 연계된 뉴클레오시드로 구성된, 올리고머 화합물.
청구항 1-46 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오티드는 20개의 연계된 뉴클레오시드로 구성된, 올리고머 화합물.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Aeo mCeo Ges Gds Tds Ads Tds Tds Ads Gds Tds Gds Tds mCeo Teo Tes mCes Ae (서열 식별 번호: 126), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
Ges mCeo Aeo mCeo Ges Gds Tds Ads Tds Tds Ads Gds Tds Gds Tds mCeo Teo Tes mCes Ae (서열 식별 번호: 126), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo Teo Teo mCes Tds mCds Ads Ads Ads Tds mCds Ads Gds Gds Teo Geo Tes Aes mCe (서열 식별 번호: 1045), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
Ges mCeo Teo Teo mCes Tds mCds Ads Ads Ads Tds mCds Ads Gds Gds Teo Geo Tes Aes mCe (서열 식별 번호: 1045), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Ges mCeo mCeo Teo Tes Tds Ads Tds Ads Ads mCds Tds Tds Tds Tds mCeo Teo Tes Tes mCe (서열 식별 번호: 2552), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
Ges mCeo mCeo Teo Tes Tds Ads Tds Ads Ads mCds Tds Tds Tds Tds mCeo Teo Tes Tes mCe (서열 식별 번호: 2552), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes Teo mCeo Aeo Ges Tds Tds Tds Ads Gds Tds Tds Gds mCds Ads Geo mCeo mCes Aes Te (서열 식별 번호: 3190), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
Tes Teo mCeo Aeo Ges Tds Tds Tds Ads Gds Tds Tds Gds mCds Ads Geo mCeo mCes Aes Te (서열 식별 번호: 3190), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
mCes mCeo mCeo Geo Tes Ads Tds Tds mCds mCds Tds mCds Tds Tds Ads mCeo mCeo Aes Tes mCe (서열 식별 번호: 3590), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
mCes mCeo mCeo Geo Tes Ads Tds Tds mCds mCds Tds mCds Tds Tds Ads mCeo mCeo Aes Tes mCe (서열 식별 번호: 3590), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
다음의 화학적 표기에 따른 변형된 올리고뉴클레오티드를 포함하는 화합물:
Tes mCes Aes Geo Tes Tds Tds Ads Gds Tds Tds Gds mCds Aeo Ges mCes mCe (서열 식별 번호: 3638), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
Tes mCes Aes Geo Tes Tds Tds Ads Gds Tds Tds Gds mCds Aeo Ges mCes mCe (서열 식별 번호: 3638), 이때,
A = 아데닌 핵염기,
mC = 5-메틸 시토신 핵염기,
G = 구아닌 핵염기,
T = 티민 핵염기,
e = 2'-MOE 당 모이어티,
d = 2'-β-D 데옥시리보실 당 모이어티,
s = 포스포로티오에이트 뉴클레오시드간 링키지, 그리고
o = 포스포디에스테르 뉴클레오시드간 링키지.
청구항 1-57 중 어느 한 항에 있어서, 변형된 올리고뉴클레오티드로 구성된, 올리고머 화합물.
청구항 1-58 중 어느 한 항에 있어서, 콘쥬게이트 모이어티 및 콘쥬게이트 링커를 포함하는 콘쥬게이트 기를 포함하는, 올리고머 화합물.
청구항 59에 있어서, 상기 콘쥬게이트 링커는 단일 결합으로 구성된, 올리고머 화합물.
청구항 59에 있어서, 상기 콘쥬게이트 링커는 절단가능한, 올리고머 화합물.
청구항 59에 있어서, 상기 콘쥬게이트 링커는 1-3개의 링커 뉴클레오시드를 포함하는, 올리고머 화합물.
청구항 59-61 중 어느 한 항에 있어서, 상기 콘쥬게이트 링커는 임의의 링커 뉴클레오시드를 포함하지 않는, 올리고머 화합물.
청구항 59-62 중 어느 한 항에 있어서, 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 5'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된, 올리고머 화합물.
청구항 59-62 중 어느 한 항에 있어서, 상기 콘쥬게이트 기는 상기 변형된 올리고뉴클레오티드의 3'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된, 올리고머 화합물.
청구항 1-57 및 60-65 중 어느 한 항에 있어서, 말단 기를 포함하는, 올리고머 화합물.
청구항 66에 있어서, 말단 기는 무염기 당 모이어티인, 올리고머 화합물.
청구항 1-67 중 어느 한 항에 있어서, 상기 올리고머 화합물은 단일-가닥으로 된 올리고머 화합물인,올리고머 화합물.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 126), 또는 이의 염.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 1045), 또는 이의 염.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 2552), 또는 이의 염.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3190), 또는 이의 염.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3590), 또는 이의 염.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3638), 또는 이의 염.
청구항 69-74 중 어느 한 항에 있어서, 나트륨염 또는 칼륨염인, 변형된 올리고뉴클레오티드.
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 126).
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 1045).
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 2552).
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3190).
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3590).
다음의 화학 구조에 따른 변형된 올리고뉴클레오티드:
(서열 식별 번호: 3638).
청구항 1-68 중 어느 한 항의 올리고머 화합물 또는 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드의 키랄 풍부 집단이며, 상기 집단은 특정 입체화학적 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부한, 키랄 풍부 집단.
청구항 82에 있어서, 상기 집단은 (Sp) 또는 (Rp) 배위를 갖는 적어도 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지를 포함하는 변형된 올리고뉴클레오티드가 풍부한, 키랄 풍부 집단.
청구항 83에 있어서, 상기 집단은 각 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된 특정 입체화학적 배위를 갖는 변형된 올리고뉴클레오티드가 풍부한, 키랄 풍부 집단.
청구항 84에 있어서, 상기 집단은 하나의 특정 포스포로티오에이트 뉴클레오시드간 링키지에서 (Rp) 배위를 갖고, 나머지 각 포스포로티오에이트 뉴클레오시드간 링키지에서 (Sp) 배위를 갖는 변형된 올리고뉴클레오티드가 풍부한, 키랄 풍부 집단.
청구항 85에 있어서, 상기 집단은 5'에서 3' 방향으로, Sp, Sp, 및 Rp 배위의 적어도 3개의 연접한 포스포로티오에이트 뉴클레오시드간 링키지를 갖는 변형된 올리고뉴클레오티드가 풍부한, 키랄 풍부 집단.
집단으로서, 청구항 1-68 중 어느 한 항의 변형된 올리고뉴클레오티드를 포함하는 올리고머 화합물의 집단, 또는 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드의 집단이며, 상기 변형된 올리고뉴클레오티드의 모든 포스포로티오에이트 뉴클레오시드간 링키지들은 스테레오랜덤인, 집단.
제 1 올리고머 화합물, 그리고 제 2 변형된 올리고뉴클레오티드를 포함하는 제 2 올리고머 화합물을 포함하는 올리고머 듀플렉스에 있어서, 상기 제 1 올리고머 화합물은 청구항 1-68 중 어느 한 항의 올리고머 화합물인, 올리고머 듀플렉스.
청구항 88에 있어서, 상기 제 2 올리고머 화합물은 12 ~ 30개의 연계된 뉴클레오시드로 구성된 제 2 변형된 올리고뉴클레오티드를 포함하고, 이때 상기 제 2 변형된 올리고뉴클레오티드의 핵염기 서열은 상기 제 1 변형된 올리고뉴클레오티드의 동일 길이 부분에 대해 적어도 90% 상보성인 적어도 8개의 핵염기 상보성 영역을 포함하는, 올리고머 듀플렉스.
청구항 88 또는 89에 있어서, 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 5'-안정화된 포스페이트 기를 포함하는, 올리고머 듀플렉스.
청구항 90에 있어서, 상기 안정화된 포스페이트 기는 시클로프로필 포스포네이트 또는 비닐 포스포네이트를 포함하는, 올리고머 듀플렉스.
청구항 88-91 중 어느 한 항에 있어서, 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 글리콜 핵산 (GNA) 당 대체물을 포함하는, 올리고머 듀플렉스.
청구항 88-92 중 어느 한 항에 있어서, 상기 제 1 올리고머 화합물의 변형된 올리고뉴클레오티드는 2'-NMA 당 모이어티를 포함하는, 올리고머 듀플렉스.
청구항 88-93 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 변형된 당 모이어티를 포함하는, 올리고머 듀플렉스.
청구항 94에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 변형된 당 모이어티는 이환 당 모이어티를 포함하는, 올리고머 듀플렉스.
청구항 95에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 이환 당 모이어티는 -O-CH2-; 및 -O-CH(CH3)-에서 선택된 2'-4' 다리를 포함하는, 올리고머 듀플렉스.
청구항 96에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 변형된 당 모이어티는 비-이환 변형된 당 모이어티를 포함하는, 올리고머 듀플렉스.
청구항 97에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 비-이환 변형된 당 모이어티는 2'-MOE 당 모이어티, 2'-F 당 모이어티, 또는 2'-OMe 당 모이어티인, 올리고머 듀플렉스.
청구항 88-98 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드는 당 대체물을 포함하는, 올리고머 듀플렉스.
청구항 88-99 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 변형된 뉴클레오시드간 링키지인, 올리고머 듀플렉스.
청구항 100에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 변형된 뉴클레오시드간 링키지는 포스포로티오에이트 뉴클레오시드간 링키지인, 올리고머 듀플렉스.
청구항 88-101 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 적어도 하나의 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지인, 올리고머 듀플렉스.
청구항 88-102 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 또는 포스포로티오에이트 뉴클레오시드간 링키지에서 독립적으로 선택된, 올리고머 듀플렉스.
청구항 88-103 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 각 뉴클레오시드간 링키지는 포스포디에스테르 뉴클레오시드간 링키지, 포스포로티오에이트 뉴클레오시드간 링키지, 또는 메실 포스포라미데이트 뉴클레오시드간 링키지에서 독립적으로 선택된, 올리고머 듀플렉스.
청구항 88-104 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드는 적어도 하나의 변형된 핵염기를 포함하는, 올리고머 듀플렉스.
청구항 105에 있어서, 상기 제 2 변형된 올리고뉴클레오티드의 변형된 핵염기는 5-메틸시토신인, 올리고머 듀플렉스.
청구항 88-106 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드는 콘쥬게이트 기를 포함하는, 올리고머 듀플렉스.
청구항 107에 있어서, 상기 콘쥬게이트 기는 콘쥬게이트 링커 및 콘쥬게이트 모이어티를 포함하는, 올리고머 듀플렉스.
청구항 108 또는 109에 있어서, 상기 콘쥬게이트 기는 상기 제 2 변형된 올리고뉴클레오티드의 5'-단부에서 상기 제 2 변형된 올리고뉴클레오티드에 부착된, 올리고머 듀플렉스.
청구항 108 또는 109에 있어서, 상기 콘쥬게이트 기는 상기 제 2 변형된 올리고뉴클레오티드의 3'-단부에서 상기 변형된 올리고뉴클레오티드에 부착된, 올리고머 듀플렉스.
청구항 108-111 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드는 말단 기를 포함하는, 올리고머 듀플렉스.
청구항 112에 있어서, 말단 기는 무염기 당 모이어티인, 올리고머 듀플렉스.
청구항 88-113 중 어느 한 항에 있어서, 상기 제 2 변형된 올리고뉴클레오티드는 10 ~ 25, 10 ~ 30, 10 ~ 50, 12 ~ 20, 12 ~ 25, 12 ~ 30, 12 ~ 50, 13 ~ 20, 13 ~ 25, 13 ~ 30, 13 ~ 50, 14 ~ 20, 14 ~ 25, 14 ~ 30, 14 ~ 50, 15 ~ 20, 15 ~ 25, 15 ~ 30, 15 ~ 50, 16 ~ 18,16 ~ 20, 16 ~ 25, 16 ~ 30, 16 ~ 50, 17 ~ 20, 17 ~ 25, 17 ~ 30, 17 ~ 50, 18 ~ 20, 18 ~ 25, 18 ~ 30, 18 ~ 50, 19 ~ 20, 19 ~ 25, 19 ~ 30, 19 ~ 50, 20 ~ 25, 20 ~ 30, 20 ~ 50, 21 ~ 25, 21 ~ 30, 21 ~ 50, 22 ~ 25, 22 ~ 30, 22 ~ 50, 23 ~ 25, 23 ~ 30, 또는 23 ~ 50개의 연계된 뉴클레오시드로 구성된, 올리고머 듀플렉스.
안티센스 화합물을 포함하는 안티세스 작용제에 있어서, 상기 안티센스 화합물은 청구항 1-68 중 어느 한 항의 올리고머 화합물, 또는 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드인, 안티센스 작용제.
청구항 115에 있어서, 상기 안티센스 작용제는 청구항 88-113 중 어느 한 항의 올리고머 듀플렉스인, 안티센스 작용제.
청구항 115 또는 116에 있어서, 상기 안티센스 작용제는 RNase H의 활성화를 통하여 ATXN1 핵산 양을 감소시킬 수 있는 RNase H 작용제인, 안티센스 작용제.
청구항 115-117 중 어느 한 항에 있어서, 상기 콘쥬게이트 기는 세포-표적화 모이어티를 포함하는, 안티센스 작용제.
청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 또는 청구항 115-117 중 어느 한 항의 안티센스 작용제, 그리고 약제학적으로 수용가능한 담체 또는 희석제를 포함하는, 약제학적 조성물.
청구항 118에 있어서, 상기 약제학적으로 수용가능한 희석제는 물, 포스페이트-완충된 염수, 또는 인공 뇌척수액인,약제학적 조성물.
청구항 119에 있어서, 상기 약제학적 조성물은 변형된 올리고뉴클레오티드 및 인공 뇌척수액으로 본질적으로 구성된, 약제학적 조성물.
청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 청구항 115-117 중 어느 한 항의 안티센스 작용제, 또는 청구항 118-120 중 어느 한 항의 약제학적 조성물을 대상체에게 투여하는 것을 포함하는 방법.
ATXN1과 연관된 질환을 가진 대상체에게 청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 청구항 115-117 중 어느 한 항의 안티센스 작용제, 또는 청구항 118-120 중 어느 한 항의 약제학적 조성물의 치료요법적으로 효과량을 투여하고; 이로써 ATXN1과 연관된 질환이 치료되는 것을 포함하는, ATXN1과 연관된 질환을 치료하는 방법.
청구항 122에 있어서, 상기 ATXN1-연관된 질환은 제1형 척수소뇌성 운동실조인, 안티센스 작용제.
청구항 122 또는 123에 있어서, 상기 ATXN1-연관된 질환의 적어도 하나의 증상 또는 특징이 개선되는, 방법.
청구항 124에 있어서, 상기 증상 또는 특징은 보행 및 사지 운동실조, 인지 장애, 말하기 또는 삼키기 어려움, 자기 공명 영상(MRI)에서의 소뇌 및/또는 뇌간의 위축, 자기 공명 분광법(MRS)을 통해 검출된 소뇌 및/또는 뇌간의 신경화학적 이상 또는 증상 발병 10-15년 이내 사망인, 방법.
청구항 122-125 중 어느 한 항에 있어서, 상기 대상체에서 ATXN1 수준이 감소되는, 방법.
세포에서 ATXN1의 발현을 감소시키는 방법이며, 상기 세포와 청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 청구항 115-117 중 어느 한 항의 안티센스 작용제, 또는 청구항 118-120 중 어느 한 항의 약제학적 조성물을 접촉시키는 것을 포함하는 방법.
청구항 127에 있어서, 상기 세포는 CNS 세포인, 방법.
ATXN1과 연관된 질환을 치료하기 위한 청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 청구항 115-117 중 어느 한 항의 안티센스 작용제, 또는 청구항 118-120 중 어느 한 항의 약제학적 조성물의 용도.
ATXN1과 연관된 질환 치료용 약물의 제조에서의 청구항 1-68 중 어느 한 항의 올리고머 화합물, 청구항 69-81 중 어느 한 항의 변형된 올리고뉴클레오티드, 청구항 82-87 중 어느 한 항의 집단, 청구항 88-114 중 어느 한 항의 올리고머 듀플렉스, 청구항 115-117 중 어느 한 항의 안티센스 작용제, 또는 청구항 118-120 중 어느 한 항의 약제학적 조성물의용도.
청구항 129 또는 130에 있어서, 상기 ATXN1과 연관된 질환은 제1형 척수소뇌성 운동실조인, 용도.
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| US20220290146A1 (en) | 2022-09-15 |
| WO2021222768A3 (en) | 2021-12-09 |
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